ethers

Summary

Top Publications

  1. pmc Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology
    P O Darnerud
    National Food Administration, Toxicology Division, Uppsala, Sweden
    Environ Health Perspect 109:49-68. 2001
  2. ncbi Recent advances in structural research on ether lipids from archaea including comparative and physiological aspects
    Yosuke Koga
    Department of Chemistry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Biosci Biotechnol Biochem 69:2019-34. 2005
  3. ncbi Biaryl ethers as novel non-nucleoside reverse transcriptase inhibitors with improved potency against key mutant viruses
    Dai Shi Su
    Department of Medicinal Chemistry and Structural Biology, Merck Research Laboratory, P O Box 4, West Point, Pennsylvania 19486, USA
    J Med Chem 52:7163-9. 2009
  4. ncbi Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) in the abiotic environment: surface water and precipitation from Ontario, Canada
    Daisuke Ueno
    Department of Environmental Sciences, Faculty of Agriculture, Saga University, Honjo 1, Saga 840 8502, Japan
    Environ Sci Technol 42:1657-64. 2008
  5. ncbi Levels and distribution of polybrominated diphenyl ethers in water, surface sediments, and bivalves from the San Francisco Estuary
    Daniel R Oros
    San Francisco Estuary Institute, Oakland, California 94621, USA
    Environ Sci Technol 39:33-41. 2005
  6. ncbi Semiautomated high-throughput extraction and cleanup method for the measurement of polybrominated diphenyl ethers and polybrominated and polychlorinated biphenyls in breast milk
    Andreas Sjodin
    National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, Centers for Disease Control and Prevention, 4770 Buford Hwy NE Mail Stop F 17, Atlanta, Georgia 30341, USA
    Anal Chem 76:4508-14. 2004
  7. ncbi An overview of policies for managing polybrominated diphenyl ethers (PBDEs) in the Great Lakes basin
    Jessica Ward
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    Environ Int 34:1148-56. 2008
  8. ncbi Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection
    Jelena M Janjic
    Department of Biological Sciences and Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, 4400 Fifth Ave, Pittsburgh, Pennsylvania 15213, USA
    J Am Chem Soc 130:2832-41. 2008
  9. ncbi Dietary accumulation and metabolism of polybrominated diphenyl ethers by juvenile carp (Cyprinus carpio)
    Heather M Stapleton
    Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, Solomons, Maryland 20688, USA
    Environ Toxicol Chem 23:1939-46. 2004
  10. pmc Oxidative cleavage of diverse ethers by an extracellular fungal peroxygenase
    Matthias Kinne
    From the Unit of Environmental Biotechnology, International Graduate School of Zittau, 02763 Zittau, Germany
    J Biol Chem 284:29343-9. 2009

Detail Information

Publications309 found, 100 shown here

  1. pmc Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology
    P O Darnerud
    National Food Administration, Toxicology Division, Uppsala, Sweden
    Environ Health Perspect 109:49-68. 2001
    Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in plastics (concentration, 5--30%) and in textile coatings...
  2. ncbi Recent advances in structural research on ether lipids from archaea including comparative and physiological aspects
    Yosuke Koga
    Department of Chemistry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Biosci Biotechnol Biochem 69:2019-34. 2005
    ..In the last part of this review we discuss this problem...
  3. ncbi Biaryl ethers as novel non-nucleoside reverse transcriptase inhibitors with improved potency against key mutant viruses
    Dai Shi Su
    Department of Medicinal Chemistry and Structural Biology, Merck Research Laboratory, P O Box 4, West Point, Pennsylvania 19486, USA
    J Med Chem 52:7163-9. 2009
    Biaryl ethers were recently reported as potent NNRTIs. Herein we disclose a detailed SAR study that led to the biaryl ether 6...
  4. ncbi Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) in the abiotic environment: surface water and precipitation from Ontario, Canada
    Daisuke Ueno
    Department of Environmental Sciences, Faculty of Agriculture, Saga University, Honjo 1, Saga 840 8502, Japan
    Environ Sci Technol 42:1657-64. 2008
    Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) have been identified as metabolites of PBDEs, and also as compounds of natural origin in the marine environment; however, there has only been very limited study of their presence in ..
  5. ncbi Levels and distribution of polybrominated diphenyl ethers in water, surface sediments, and bivalves from the San Francisco Estuary
    Daniel R Oros
    San Francisco Estuary Institute, Oakland, California 94621, USA
    Environ Sci Technol 39:33-41. 2005
    Polybrominated diphenyl ethers (PBDEs) were found in water, surface sediments, and bivalve samples that were collected from the San Francisco Estuary in 2002...
  6. ncbi Semiautomated high-throughput extraction and cleanup method for the measurement of polybrominated diphenyl ethers and polybrominated and polychlorinated biphenyls in breast milk
    Andreas Sjodin
    National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, Centers for Disease Control and Prevention, 4770 Buford Hwy NE Mail Stop F 17, Atlanta, Georgia 30341, USA
    Anal Chem 76:4508-14. 2004
    A semiautomated extraction and cleanup method has been developed to measure eight polybrominated diphenyl ethers (PBDEs), 2,2',4,4',5,5'-hexabromobiphenyl (BB-153), and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153)...
  7. ncbi An overview of policies for managing polybrominated diphenyl ethers (PBDEs) in the Great Lakes basin
    Jessica Ward
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    Environ Int 34:1148-56. 2008
    ..Polybrominated diphenyl ethers (PBDEs), a class of brominated flame retardant, are among such chemicals, whose concentration in the Great Lakes ..
  8. ncbi Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection
    Jelena M Janjic
    Department of Biological Sciences and Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, 4400 Fifth Ave, Pittsburgh, Pennsylvania 15213, USA
    J Am Chem Soc 130:2832-41. 2008
    ..The intracellular fluorescence signal is directly proportional to the 19F NMR signal and can be used to calibrate cell loading in vitro...
  9. ncbi Dietary accumulation and metabolism of polybrominated diphenyl ethers by juvenile carp (Cyprinus carpio)
    Heather M Stapleton
    Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, Solomons, Maryland 20688, USA
    Environ Toxicol Chem 23:1939-46. 2004
    Polybrominated diphenyl ethers (PBDEs) are hydrophobic organic contaminants with properties and nomenclature similar to polychlorinated biphenyls (PCBs)...
  10. pmc Oxidative cleavage of diverse ethers by an extracellular fungal peroxygenase
    Matthias Kinne
    From the Unit of Environmental Biotechnology, International Graduate School of Zittau, 02763 Zittau, Germany
    J Biol Chem 284:29343-9. 2009
    ..peroxygenase of Agrocybe aegerita catalyzed the H2O2-dependent cleavage of environmentally significant ethers, including methyl t-butyl ether, tetrahydrofuran, and 1,4-dioxane...
  11. ncbi Prolonged time to pregnancy in female workers exposed to ethylene glycol ethers in semiconductor manufacturing
    Pau Chung Chen
    Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan
    Epidemiology 13:191-6. 2002
    ..Previous research on reproductive effects of working in the semiconductor industry is limited and has produced conflicting results...
  12. ncbi Chiral recognition of ethers by NMR spectroscopy
    Helmut Duddeck
    Leibniz University Hannover, Institute of Organic Chemistry, Schneiderberg 1B, D 30167 Hannover, Germany
    Chirality 21:51-68. 2009
    Enantiomers of chiral ethers and acetals are notoriously difficult to differentiate because their reactivity is low and they are poor donors to any Lewis acid or metal ion. As an exception, epoxides are somewhat better donors...
  13. ncbi High efficiency synthesis of F-18 fluoromethyl ethers: an attractive alternative for C-11 methyl groups in positron emission tomography radiopharmaceuticals
    Chansoo Park
    Department of Chemistry, Sogang University, 35 Baekbeomro Mapogu, Seoul 121 742, Korea
    Org Lett 15:4346-9. 2013
    A rapid and efficient method for the synthesis of O-fluoromethyl aliphatic and aromatic ethers is presented...
  14. ncbi The INSERM expert review on glycol ethers: findings and recommendations
    L Multigner
    INSERM U 625, Campus de Beaulieu, Universite de Rennes 1, 35042 Rennes Cedex, France
    Toxicol Lett 156:29-37. 2005
    The use of glycol ethers and their effects on health have recently attracted the attention of the French health authorities...
  15. ncbi Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase
    Ya ming Xu
    Department of Chemistry, University of Virginia, Charlottesville, VA 22901, USA
    Bioorg Med Chem 13:657-9. 2005
    ..Two polybrominated diphenyl ethers, 3,5-dibromo-2-(2',4'-dibromophenoxy)phenol (1) and 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol (2) were isolated ..
  16. ncbi Trophodynamics of polybrominated diphenyl ethers in the marine food web of Bohai Bay, North China
    Yi Wan
    College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Environ Sci Technol 42:1078-83. 2008
    Polybrominated diphenyl ethers (PBDEs) are of great environmental concern due to the exponential increase of the concentrations in the environment, especially in high trophic level organisms, and the trophodynamics of these chemicals in ..
  17. ncbi Radical alpha-C-H hydroxyalkylation of ethers and acetal
    Takehiko Yoshimitsu
    Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan
    J Org Chem 70:2342-5. 2005
    ..This study presents a very unique and simple means for the radical alpha-C-H hydroxyalkylation of oxygen-containing compounds...
  18. ncbi Digestive stability of hydroxytyrosol, hydroxytyrosyl acetate and alkyl hydroxytyrosyl ethers
    Gema Pereira-Caro
    IFAPA Centro Venta del Llano, Road Bailen Motril, Mengibar, Jaen, Spain
    Int J Food Sci Nutr 63:703-7. 2012
    ..in virgin olive oil, hydroxytyrosol (HTy) and hydroxytyrosyl acetate (HTy-Ac) and a new series of hydroxytyrosyl ethers (methyl, ethyl and butyl hydroxytyrosyl ethers) was evaluated by a simulated digestion procedure...
  19. ncbi Polybrominated diphenyl ethers in seafood products of south China
    Jian yang Guo
    State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China
    J Agric Food Chem 55:9152-8. 2007
    ....
  20. ncbi Similarities in bioaccumulation patterns of polychlorinated dibenzo-p-dioxins and furans and polychlorinated diphenyl ethers in laboratory-exposed oligochaetes and semipermeable membrane devices and in field-collected chironomids
    Merja Lyytikäinen
    University of Joensuu, Department of Biology, P O Box 111, FIN 80101 Joensuu, Finland
    Environ Toxicol Chem 22:2405-15. 2003
    ..and they were analyzed for polychlorinated dibenzo-p-dioxins and furans (PCDD/F) and polychlorinated diphenyl ethers (PCDE)...
  21. ncbi Polybrominated diphenyl ethers and polychlorinated biphenyls in a marine foodweb of coastal Florida
    Boris Johnson-Restrepo
    Wadsworth Center, New York State Department of Health, USA
    Environ Sci Technol 39:8243-50. 2005
    ..of marine mammals (dolphins) collected from Florida coastal waters were analyzed for polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) to evaluate biomagnification factors (BMF) of these contaminants in a ..
  22. ncbi Synthesis of indenyl ethers by gold(I)-catalyzed intramolecular carboalkoxylation of alkynes
    Pascal Dubé
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Am Chem Soc 128:12062-3. 2006
    ..carboalkoxylation of alkynes to form indanone derivatives from readily available ortho-acetylenic benzylic ethers is described...
  23. ncbi Atmospheric transport of polybrominated diphenyl ethers and polychlorinated biphenyls to the Baltic Sea
    Arnout F H ter Schure
    Chemical Ecology and Ecotoxicology, Department of Ecology, Lund University, Ecology Building, S 223 62 Lund, Sweden
    Environ Sci Technol 38:1282-7. 2004
    The atmospheric transport of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) was compared by measuring concentrations in air and deposition on an island located in the central basin of the Baltic Sea...
  24. ncbi Effect of sewage-sludge application on concentrations of higher-brominated diphenyl ethers in soils and earthworms
    Ulla Sellström
    Department of Applied Environmental Science, Stockholm University, Sweden
    Environ Sci Technol 39:9064-70. 2005
    Polybrominated diphenyl ethers (PBDEs), including octa-decaBDEs, were found in soil and earthworm samples collected in 2000 from three research stations (reference plots and sewage-sludge-amended plots) and two farms (reference and ..
  25. pmc Nanopod formation through gold nanoparticle templated and catalyzed cross-linking of polymers bearing pendant propargyl ethers
    Ke Zhang
    Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3113, USA
    J Am Chem Soc 132:15151-3. 2010
    ..The transformations involved in the cross-linking process are unprecedented on the surface of a gold particle. A tentative cross-linking mechanism is proposed...
  26. pmc Enantioselective hydroformylation of N-vinyl carboxamides, allyl carbamates, and allyl ethers using chiral diazaphospholane ligands
    Richard I McDonald
    Department of Chemistry, University of Wisconsin Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA
    J Am Chem Soc 132:14027-9. 2010
    ..complexes of diazaphospholane ligands catalyze the asymmetric hydroformylation of N-vinyl carboxamides, allyl ethers, and allyl carbamates; products include 1,2- and 1,3-aminoaldehydes and 1,3-alkoxyaldehydes...
  27. ncbi Organocatalyzed enantioselective protonation of silyl enol ethers: scope, limitations, and application to the preparation of enantioenriched homoisoflavones
    Thomas Poisson
    Laboratoire de Chimie Organique Bio organique Réactivité et Analyse COBRA, CNRS UMR 6014 and FR 3038, Universite et INSA de Rouen, Rue Tesniere, Mont Saint Aignan 76130 F, France
    J Org Chem 75:7704-16. 2010
    In the present work, enantioselective protonation of silyl enol ethers is reported by means of a variety of chiral nitrogen bases as catalysts, mainly derived from cinchona alkaloids, in the presence of various protic nucleophiles as ..
  28. pmc Cu-catalyzed arylation of phenols: synthesis of sterically hindered and heteroaryl diaryl ethers
    Debabrata Maiti
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Org Chem 75:1791-4. 2010
    ..This method tolerates a variety of functional groups and is effective in the synthesis of hindered diaryl ethers and heteroaryl ethers.
  29. ncbi Selective demethylation and debenzylation of aryl ethers by magnesium iodide under solvent-free conditions and its application to the total synthesis of natural products
    Kai Bao
    School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, PR China
    Org Biomol Chem 7:5084-90. 2009
    An efficient selective demethylation and debenzylation method for aryl methyl/benzyl ethers using magnesium iodide under solvent-free conditions has been developed and applied to the synthesis of natural flavone and biphenyl glycosides...
  30. ncbi UV irradiation of polycyclic aromatic hydrocarbons in ices: production of alcohols, quinones, and ethers
    M P Bernstein
    NASA Ames Research Center, Mail Stop 245 6, Moffett Field, CA 94035 1000, USA
    Science 283:1135-8. 1999
    ..Peripheral carbon atoms were oxidized, producing aromatic alcohols, ketones, and ethers, and reduced, producing partially hydrogenated aromatic hydrocarbons, molecules that account for the interstellar ..
  31. ncbi Synthesis of new liquid crystalline diglycidyl ethers
    Issam Ahmed Mohammed
    School of Industrial Technology, University Sains Malaysia, Penang 11800, Malaysia
    Molecules 17:645-56. 2012
    ..and subsequent reactions between these phenolic Schiff bases and epichlorohydrin to produce new diglycidyl ethers Ia-VIa. The structures of these compounds were confirmed by CHN, FT-IR, (1)H-NMR, and (13)C-NMR spectroscopy...
  32. ncbi Effects of the water content of soda lime on compound A concentration in the anesthesia circuit in sevoflurane anesthesia
    H Bito
    Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan
    Anesthesiology 88:66-71. 1998
    ..This goal of this study was to determine if compound A concentrations can be reduced by using soda lime with water added...
  33. ncbi Screening of polybrominated diphenyl ethers in blue mussels, marine and freshwater sediments in Denmark
    J H Christensen
    National Environmental Research Institute, Department of Environmental Chemistry, Frederiksborgvej 399, 4000 Roskilde, Denmark
    J Environ Monit 3:543-7. 2001
    The first screening of polybrominated diphenyl ethers (PBDEs) in sediments and blue mussels (Mytilus edulis) collected in the Danish marine and freshwater environment is presented in this work...
  34. ncbi Biosynthesis of ethers: unusual or common natural events?
    Pablo Domínguez de María
    Process and Product Technology Department, AkzoNobel BV, Velperweg 76, Arnhem, The Netherlands
    Nat Prod Rep 27:370-92. 2010
    ..Depending on the compound and on the (micro) environment in which the reaction is performed, ethers are produced by very different (enzymatic) reactions, thus providing an impressive display of how Nature has ..
  35. ncbi Passive sampling of glycol ethers and their acetates in indoor air
    H Plaisance
    Ecole des Mines de Douai, 941, rue Charles Bourseul, BP 838, Cedex, DOUAI 59508, France
    J Environ Monit 10:517-26. 2008
    ..the performances of a thermal desorbable radial diffusive sampler for the weekly measurement of eight glycol ethers in indoor air and described the results of an application of this method carried out as part of HABIT'AIR Nord - ..
  36. pmc Facile oxidative cleavage of 4-O-benzyl ethers with dichlorodicyanoquinone in rhamno- and mannopyranosides
    David Crich
    Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607 7061, USA
    J Org Chem 72:3581-4. 2007
    On exposure to dichlorodicyanoquinone in wet dichloromethane at room temperature, equatorial 4-O-benzyl ethers are removed with moderate selectivity in the presence of other benzyl ethers in glycopyranosides and glycothiopyranosides.
  37. ncbi Synthesis and biological evaluation of 12 allenic aromatic ethers
    San Yong Wang
    School of Chemistry and Chemical Engineering, Sun Yat Sen Zhongshan University, Guangzhou 510275, China
    Bioorg Med Chem Lett 17:2785-8. 2007
    Twelve allenic aromatic ethers, some of them are natural products isolated from the mangrove fungus Xylaria sp. 2508 in the South China Sea, were synthesized. Their antitumor activities against KB and KBv200 cells were determined...
  38. ncbi Assessing the long-range transport potential of polybrominated diphenyl ethers: a comparison of four multimedia models
    Frank Wania
    Division of Physical Sciences, University of Toronto at Scarborough, 1265 Military Trail, Toronto, Ontario M1C 1A4, Canada
    Environ Toxicol Chem 22:1252-61. 2003
    ..literature search of environmentally relevant physical-chemical properties for nine polybrominated diphenyl ethers (PBDE), ranging from a monobrominated congener to the fully brominated decabromodiphenyl ether, were evaluated and ..
  39. ncbi Role of renal cysteine conjugate beta-lyase in the mechanism of compound A nephrotoxicity in rats
    E D Kharasch
    Department of Anesthesiology, University of Washington, Seattle 98195, USA
    Anesthesiology 86:160-71. 1997
    ..Compound A nephrotoxicity has not been observed in humans. The authors tested the hypothesis that renal uptake of compound A S-conjugates and metabolism by renal cysteine conjugate beta-lyase mediate compound A nephrotoxicity in rats...
  40. ncbi Aerobic biotransformation of polybrominated diphenyl ethers (PBDEs) by bacterial isolates
    Kristin R Robrock
    Department of Civil and Environmental Engineering, University of California, Berkeley, CA, USA
    Environ Sci Technol 43:5705-11. 2009
    Polybrominated diphenyl ethers (PBDEs) are flame retardants that have been used in consumer products and furniture for three decades...
  41. ncbi A comparison between vital capacity induction and tidal breathing induction techniques for the induction of anesthesia and compound A production
    Shu Jie Liu
    Department of Anesthesiology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China
    Chin Med J (Engl) 123:2336-40. 2010
    ..The aim of this study was to compare them using sevoflurane with respect to induction time, complications of inhalation induction, and compound A production in adult patients...
  42. ncbi Comparative evaluation of three high-performance liquid chromatography-based Kow estimation methods for highly hydrophobic organic compounds: polybrominated diphenyl ethers and hexabromocyclododecane
    Stephen J Hayward
    Department of Chemical Engineering and Applied Chemistry and of Physical and Environmental Sciences, University of Toronto at Scarborough, 1265 Military Trail, Toronto, Ontario M1C 1A4, Canada
    Environ Toxicol Chem 25:2018-27. 2006
    ..speed, precision, and accuracy, with the latter judged by comparison with Kow values for polybrominated diphenyl ethers and polychlorinated naphthalenes as reported in the literature, a gradient elution combined with an exponential ..
  43. ncbi Etherification of biodiesel-derived glycerol with ethanol for fuel formulation over sulfonic modified catalysts
    Juan A Melero
    Department of Chemical and Environmental Technology, ESCET, Universidad Rey Juan Carlos, c Tulipan s n, E 28933 Móstoles, Madrid, Spain
    Bioresour Technol 103:142-51. 2012
    ..glycerol with anhydrous ethanol over arenesulfonic acid-functionalized mesostructured silicas to produce ethyl ethers of glycerol that can be used as gasoline or diesel fuel biocomponents...
  44. ncbi (E)- and (Z)-1,2,4-triazolylchromanone oxime ethers as conformationally constrained antifungals
    Saeed Emami
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, PO Box 48175 861, Sari, Iran
    Bioorg Med Chem 12:3971-6. 2004
    A series of 1,2,4-triazolylchromanone oxime ethers were synthesized and tested for in vitro antifungal activity...
  45. pmc Correlation of bilayer membrane cation transport and biological activity in alkyl-substituted lariat ethers
    W Matthew Leevy
    Departments of Chemistry and Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8103, St Louis, MO 63110, USA
    Org Biomol Chem 3:1647-52. 2005
    Dialkyldiaza-18-crown-6 lariat ethers having twin n-octyl, n-decyl, n-dodecyl, n-tetradecyl, n-hexadecyl, 1-oxodecyl and 1-oxododecyl side arms were prepared and studied...
  46. ncbi Poly-ethers from Winogradskyella poriferorum: Antifouling potential, time-course study of production and natural abundance
    Swagatika Dash
    KAUST Global Collaborative Research, Division of Life Science, Hong Kong University of Science and Technology, HKSAR, China
    Bioresour Technol 102:7532-7. 2011
    ..Five poly-ethers were isolated and partially characterized based on nuclear magnetic resonance (NMR) spectroscopy and mass ..
  47. ncbi C2-hydroxyglycosylation with glycal donors. Probing the mechanism of sulfonium-mediated oxygen transfer to glycal enol ethers
    Eiji Honda
    Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Am Chem Soc 124:7343-52. 2002
    ..investigations into this reaction revealed a novel process for sulfonium-mediated oxidation of glycal enol ethers in which the sulfoxide oxygen atom is stereoselectively transferred to the C2-position of the glycal...
  48. ncbi Selective, nickel-catalyzed hydrogenolysis of aryl ethers
    Alexey G Sergeev
    Department of Chemistry, University of Illinois, 600 South Matthews Avenue, Urbana, IL 61801, USA
    Science 332:439-43. 2011
    Selective hydrogenolysis of the aromatic carbon-oxygen (C-O) bonds in aryl ethers is an unsolved synthetic problem important for the generation of fuels and chemical feedstocks from biomass and for the liquefaction of coal...
  49. ncbi Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats
    E D Kharasch
    Department of Anesthesiology, University of Washington, Seattle, Washington 98195, USA
    Toxicol Appl Pharmacol 160:49-59. 1999
    ..The quantitative assay developed herein may provide a biomarker for FDVE exposure and relative metabolism via toxification and detoxifying pathways, applicable to animal and human investigations...
  50. pmc Formation of alkenes via degradation of tert-alkyl ethers and alcohols by Aquincola tertiaricarbonis L108 and Methylibium spp
    Franziska Schäfer
    Department of Environmental Microbiology, Helmholtz Centre for Environmental Research UFZ, Permoserstr 15, 04318 Leipzig, Germany
    Appl Environ Microbiol 77:5981-7. 2011
    ..The possible use of alkene formation as an easy-to-measure indicator of aerobic fuel oxygenate biodegradation in contaminated aquifers is discussed...
  51. ncbi Assessing the toxic effects of ethylene glycol ethers using Quantitative Structure Toxicity Relationship models
    Patricia Ruiz
    Computational Toxicology Methods Development Laboratory, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30333, USA
    Toxicol Appl Pharmacol 254:198-205. 2011
    ..The use of glycol ethers and their health effects have recently attracted the attention of international organizations such as the World ..
  52. ncbi Four new aromatic allenic ethers from the fungus Xylaria sp. No. 2508
    San Yong Wang
    School of Chemistry and Chemical Engineering, Zhongshan University, Guangzhou, China
    Nat Prod Res 22:612-7. 2008
    Four new aromatic allenic ethers, (7E)-3-(4-buta-2,3-dienyloxy-3-methoxy-phenyl)-acrylic acid methyl ester (1), (7E)-3-[4-(4-buta-2,3-dienyloxy-benzyloxy)-phenyl]-acrylic acid methyl ester (2), 4-(4-buta-2,3-dienyloxy-benzyloxy)-benzoic ..
  53. ncbi Effects of hexabromocyclododecane and polybrominated diphenyl ethers on mRNA expression in chicken (Gallus domesticus) hepatocytes
    Doug Crump
    Environment Canada, National Wildlife Research Centre, 1125 Colonel By Drive, Ottawa, Ontario, Canada
    Toxicol Sci 106:479-87. 2008
    Hexabromocyclododecane (HBCD) and polybrominated diphenyl ethers (PBDEs) are additive flame retardants used in a wide range of consumer products...
  54. ncbi Synthesis of analogues of Eunicea gamma-cembranolides containing cyclic ethers via saponification
    A D Rodriguez
    Department of Chemistry, University of Puerto Rico, P O Box 23346, U P R Station, San Juan, Puerto Rico 00931 3346
    J Org Chem 66:648-58. 2001
    ..While it was shown that a variety of structural modifications are possible, these transformations led typically to nontoxic synthetic cembranoids...
  55. ncbi Distribution of polybrominated diphenyl ethers in human umbilical cord serum, paternal serum, maternal serum, placentas, and breast milk from Madrid population, Spain
    B Gómara
    Department of Instrumental Analysis and Environmental Chemistry, Institute of General Organic Chemistry, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain
    Environ Sci Technol 41:6961-8. 2007
    ..The presence of PBDEs in cord blood and placenta samples indicates that there is prenatal exposure of PBDEs, which could continue after birth via breast milk...
  56. ncbi Identification of antitumor activity of pyrazole oxime ethers
    Hyun Ja Park
    Bio organic Science Division, Korea Research Institute of Chemical Technology, PO Box 107, Yusong, Taejon 305 600, Republic of Korea
    Bioorg Med Chem Lett 15:3307-12. 2005
    ..A series of pyrazole oxime ether derivatives were prepared and examined as cytotoxic agents. In particular, 5-phenoxypyrazole was comparable to doxorubicin, while exhibiting very potent cytotoxicity against XF 498 and HCT15...
  57. ncbi Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea
    Novriyandi Hanif
    Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903 0213, Japan
    J Nat Prod 70:432-5. 2007
    Four new (1-4) and 10 known polybrominated diphenyl ethers (5-14) have been isolated from the title sponge. The structures of the new entities were elucidated by interpretation of spectroscopic data and chemical transformations...
  58. ncbi Preliminary assessment of polybrominated diphenyl ethers (PBDEs) in the Scottish aquatic environment, including the Firth of Clyde
    L Webster
    Fisheries Research Services Marine Laboratory, 375 Victoria Road, Aberdeen, Scotland, UK, AB11 9DB
    J Environ Monit 10:463-73. 2008
    This paper presents preliminary data on polybrominated diphenyl ethers (PBDEs) in the Scottish aquatic environment...
  59. ncbi Human exposure to polybrominated diphenyl ethers through the diet
    Jose L Domingo
    Laboratory of Toxicology and Environmental Health, School of Medicine, Rovira i Virgili University, San Lorenzo 21, 43201 Reus, Spain
    J Chromatogr A 1054:321-6. 2004
    Polybrominated diphenyl ethers (PBDEs), a class of brominated flame retardants, are used in a variety of consumer products being produced in notable quantities. PBDEs have been detected in environmental samples...
  60. pmc Tunable bifunctional silyl ether cross-linkers for the design of acid-sensitive biomaterials
    Matthew C Parrott
    Departments of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, United States
    J Am Chem Soc 132:17928-32. 2010
    ..These novel materials could be useful for numerous biomedical applications, including drug delivery, tissue repair, and general surgery...
  61. ncbi Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists
    David L Gray
    Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, United States
    Bioorg Med Chem Lett 19:6604-7. 2009
    ..Several iterations of design, synthesis, and testing led to substituted piperidine diphenyl ethers which are potent NRIs with 5-HT1(A) partial agonist properties...
  62. ncbi Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers
    N J Lawrence
    Department of Chemistry, UMIST, Manchester, UK
    Bioorg Med Chem Lett 11:51-4. 2001
    A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity...
  63. pmc Hydroxylated metabolites of polybrominated diphenyl ethers in human blood samples from the United States
    Xinghua Qiu
    School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana, USA
    Environ Health Perspect 117:93-8. 2009
    A previous study from our laboratory showed that polybrominated diphenyl ethers (PBDEs) were metabolized to hydroxylated PBDEs (HO-PBDEs) in mice and that para-HO-PBDEs were the most abundant and, potentially, the most toxic metabolites.
  64. pmc Interactions of polybrominated diphenyl ethers with the aryl hydrocarbon receptor pathway
    A K Peters
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80176, Yalelaan 2, 3508 TD Utrecht, The Netherlands
    Toxicol Sci 92:133-42. 2006
    Polybrominated diphenyl ethers (PBDEs) are brominated flame retardants that have been in use as additives in various consumer products...
  65. ncbi Polybrominated diphenyl ethers, perfluorinated compounds and chlorinated pesticides in swordfish (Xiphias gladius) from the Mediterranean Sea
    Simonetta Corsolini
    Dipartimento di Scienze Ambientali G Sarfatti, University of Siena, Via P A Mattioli, 4, I 53100 Siena, Italy
    Environ Sci Technol 42:4344-9. 2008
    ..The estimated daily ingestion of PBDEs and DDTs through diet was lower than the acceptable weekly intakes proposed by the World Health Organization...
  66. ncbi Polybrominated diphenyl ethers, polychlorinated biphenyls and organochlorine pesticides in sediment cores from the Western Scheldt river (Belgium): analytical aspects and depth profiles
    A Covaci
    Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
    Environ Int 31:367-75. 2005
    ..PCBs) and selected organochlorinated pesticides (OCPs) and organobromines, such as polybrominated diphenyl ethers (PBDEs), in sediment samples was optimised using CRM 536 (PCBs in freshwater sediment)...
  67. ncbi Synthesis of new 2-naphthyl ethers and their protective activities against DNA damage induced by bleomycin-iron
    Bakr F Abdel-Wahab
    Applied Organic Chemistry Department, National Research Center, Dokki, Giza, Egypt
    Chem Pharm Bull (Tokyo) 57:1348-51. 2009
    ..Compound 2 showed the greatest protection against DNA damage, thus diminishing chromogen formation between the damaged DNA and thiobarbituric acid...
  68. ncbi Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers
    Ozden Ozel Güven
    Department of Chemistry, Zonguldak Karaelmas University, 67100 Zonguldak, Turkey
    Bioorg Med Chem Lett 17:2233-6. 2007
    In this study, a series of novel phenyl- and benzimidazole-substituted benzyl ethers were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Methicillin-resistant S...
  69. ncbi Serum concentrations of polybrominated diphenyl ethers (PBDEs) and polybrominated biphenyl (PBB) in the United States population: 2003-2004
    Andreas Sjodin
    Centers for Disease Control and Prevention, National Center for Environmental Health, 4770 Buford Highway NE, Atlanta, Georgia 30341, USA
    Environ Sci Technol 42:1377-84. 2008
    Polybrominated diphenyl ethers (PBDEs) and 2,2',4,4',5,5'-hexabromobiphenyl (BB-153) are chemicals known as brominated flame retardants...
  70. ncbi Polybrominated diphenyl ethers in house dust in Singapore
    Jing Tan
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117576, Singapore
    Chemosphere 66:985-92. 2007
    The use of polybrominated diphenyl ethers (PBDEs) as flame retardants in Singapore is not strictly regulated; therefore these compounds can be readily found in furniture, electronic devices, and building materials...
  71. ncbi GC/MS analysis of polybrominated diphenyl ethers in fish collected from the Inland Sea of Seto, Japan
    K Akutsu
    Osaka Prefectural Institute of Public Health, Japan
    Chemosphere 44:1325-33. 2001
    Development of an analytical method for polybrominated diphenyl ethers (PBDEs) in fish and their concentration in Japanese marine fish were investigated. Fish homogenate was extracted with diethyl ether/hexane (1 + 3)...
  72. ncbi Isolation and characterization of polybrominated diphenyl ethers as inhibitors of microtubule assembly from the marine sponge Phyllospongia dendyi collected at Palau
    Hongwei Liu
    Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato ku, Tokyo 108 8477, Japan
    J Nat Prod 67:472-4. 2004
    Two new polybrominated diphenyl ethers (1 and 2) were isolated by bioassay-guided separations together with nine known compounds (3-11) from the marine sponge Phyllospongia dendyi collected from Palau...
  73. ncbi Global assessment of polybrominated diphenyl ethers in farmed and wild salmon
    Ronald A Hites
    School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana 47405, USA
    Environ Sci Technol 38:4945-9. 2004
    ..In this paper, we extend these results to polybrominated diphenyl ethers (PBDEs) and show that farm-raised salmon have higher levels of these compounds than wild salmon...
  74. ncbi Neonatal exposure to higher brominated diphenyl ethers, hepta-, octa-, or nonabromodiphenyl ether, impairs spontaneous behavior and learning and memory functions of adult mice
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Toxicol Sci 92:211-8. 2006
    Polybrominated diphenyl ethers (PBDEs), used as flame retardants, have been shown to be increasing in the environment and in human mother's milk...
  75. doi Ketone super silyl enol ethers in sequential reactions: diastereoselective generation of tertiary carbinols in one pot
    Matthew B Boxer
    Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA
    J Am Chem Soc 130:1580-2. 2008
  76. pmc Children show highest levels of polybrominated diphenyl ethers in a California family of four: a case study
    Douglas Fischer
    Oakland Tribune, Oakland, California 94612, USA
    Environ Health Perspect 114:1581-4. 2006
    Polybrominated diphenyl ethers (PBDEs), a major class of flame retardants, are ubiquitous environmental contaminants with particularly high concentrations in humans from the United States...
  77. pmc Polybrominated diphenyl ethers (PBDEs) in U.S. mothers' milk
    Arnold Schecter
    University of Texas Health Sciences Center, School of Public Health, Dallas Regional Campus, Dallas, Texas 75390, USA
    Environ Health Perspect 111:1723-9. 2003
    ..S. population. Other routes of intake may also be significant...
  78. ncbi Total synthesis and complete assignment of the stereostructure of a cytotoxic bromotriterpene polyether (+)-aurilol
    Yoshiki Morimoto
    Department of Chemistry, Graduate School of Science, Osaka City University, Sumiyoshi ku, Osaka 558 8585, Japan
    J Am Chem Soc 127:5806-7. 2005
    ....
  79. ncbi The biosynthesis of polyketide-derived polycyclic ethers
    Andrew R Gallimore
    Dept of Biochemistry, 80 Tennis Court Rd, Cambridge, CB2 1GA, UK
    Nat Prod Rep 26:266-80. 2009
    The biosynthetic pathways to polyketide-derived polycyclic ethers, in bacteria, plants and marine organisms, have, until now, tended to be considered separately...
  80. ncbi Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation
    Steven M Johnson
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Med Chem 48:1576-87. 2005
    ..Of the library's 95 compounds, 31 were active inhibitors of TTR amyloid formation in vitro. The bisaryloxime ethers selectively stabilize the native tetrameric state of TTR over the dissociative transition state under ..
  81. ncbi Microbial reductive debromination of polybrominated diphenyl ethers (PBDEs)
    Jianzhong He
    Department of Civil and Environmental Engineering, University of California at Berkeley, Berkeley, California 94720 1710, USA
    Environ Sci Technol 40:4429-34. 2006
    Polybrominated diphenyl ethers (PBDEs) are a class of widely used flame retardants that have recently been detected in environmental samples, diverse biota, human blood serum, and breast milk at exponentially increasing concentrations...
  82. ncbi Is house dust the missing exposure pathway for PBDEs? An analysis of the urban fate and human exposure to PBDEs
    Heather A Jones-Otazo
    Department of Geography, Centre for Urban Health Initiatives, University of Toronto, 100 St George Street, Toronto, Ontario, Canada
    Environ Sci Technol 39:5121-30. 2005
    ..Ingestion of dust can lead to almost 100-fold higher exposure than "average" for a toddler with a high dust intake rate living in a home in which PBDE concentrations are elevated...
  83. ncbi Polybrominated diphenyl ether flame retardants in the U.S. population: current levels, temporal trends, and comparison with dioxins, dibenzofurans, and polychlorinated biphenyls
    Arnold Schecter
    University of Texas School of Public Health, Dallas Campus, 6011 Harry Hines Boulevard V8 112, Dallas, TX 75390, USA
    J Occup Environ Med 47:199-211. 2005
    ....
  84. ncbi Polybrominated diphenyl ethers and polychlorinated biphenyls in human adipose tissue from New York
    Boris Johnson-Restrepo
    Wadsworth Center, New York State Department of Health and Department of Environmental Health Sciences, State University of New York at Albany, Empire State Plaza, P O Box 509, Albany, New York 12201 0509, USA
    Environ Sci Technol 39:5177-82. 2005
    ..n=52) collected in New York City during 2003-2004 were analyzed for the presence of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs)...
  85. ncbi Precursor-directed biosynthesis of stilbene methyl ethers in Escherichia coli
    Yohei Katsuyama
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    Biotechnol J 2:1286-93. 2007
    ..Furthermore, the OsPMT gene turned out to be useful in production of unnatural stilbene methyl ethers due to its rather relaxed substrate specificity; various carboxylic acids supplemented as precursors, such as p-..
  86. ncbi Novel unsaturated sucrose ethers and their application as monomers
    Carina C Crucho
    REQUIMTE, Departamento de Química FCT, Universidade Nova de Lisboa, Quinta da Torre, 2829 516 Caparica, Portugal
    Molecules 13:762-70. 2008
    Novel unsaturated ethers were synthesised in good yields starting from sucrose,using a two-step mild and efficient procedure based on the Gassman method, which consists in forming a vinyl group by the elimination of ethanol from mixed ..
  87. pmc Fate of pentabrominated diphenyl ethers in soil: abiotic sorption, plant uptake, and the impact of interspecific plant interactions
    Kevin E Mueller
    Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221 0006, USA
    Environ Sci Technol 40:6662-7. 2006
    Polybrominated diphenyl ethers (PBDEs) are potentially harmful and persistent environmental pollutants. Despite evidence that soils are a major sink for PBDEs, little is known regarding their behavior in this medium...
  88. ncbi Temporal trends, congener patterns, and sources of octa-, nona-, and decabromodiphenyl ethers (PBDE) and hexabromocyclododecanes (HBCD) in Swiss lake sediments
    Martin Kohler
    Empa, Swiss Federal Laboratories for Materials Testing and Research, Uberlandstrasse 129, 8600 Dubendorf, Switzerland
    Environ Sci Technol 42:6378-84. 2008
    ....
  89. ncbi Levels of polybrominated diphenyl ethers (PBDEs) in breast milk from central Taiwan and their relation to infant birth outcome and maternal menstruation effects
    How Ran Chao
    Department of Environmental Science and Engineering, National Pingtung University of Science and Technology, Neipu, Pingtung 912, Taiwan
    Environ Int 33:239-45. 2007
    In utero exposure to polybrominated diphenyl ethers (PBDEs) reduces the number of ovarian follicles in rat females and causes permanent effects on rat males...
  90. ncbi Gas-phase reactions of brominated diphenyl ethers with OH radicals
    Jonathan D Raff
    School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana 47405, USA
    J Phys Chem A 110:10783-92. 2006
    ..kinetics and mechanism of the reaction of OH radicals with diphenyl ether and seven polybrominated diphenyl ethers (PBDEs) with 1-2 bromines...
  91. ncbi Polybrominated diphenyl ethers in the sediments of the Great Lakes. 4. Influencing factors, trends, and implications
    An Li
    School of Public Health, Department of Civil and Materials Engineering, University of Illinois at Chicago, USA
    Environ Sci Technol 40:7528-34. 2006
    ..16 locations in the five Laurentian Great Lakes, and each was analyzed for 10 congeners of polybrominated diphenyl ethers (PBDEs) as well as selected polychlorinated biphenyls (PCBs)...
  92. pmc Brevisamide: an unprecedented monocyclic ether alkaloid from the dinoflagellate Karenia brevis that provides a potential model for ladder-frame initiation
    Masayuki Satake
    Center for Marine Science, University of North Carolina, Wilmington, 5600 Marvin K Moss Lane, Wilmington, North Carolina 28409, USA
    Org Lett 10:3465-8. 2008
    ..This report describes the structure elucidation of brevisamide based on detailed MS and NMR spectral analysis, and the importance of this new compound in shedding light on the biogenesis of fused polyethers is discussed...
  93. pmc Epoxide-opening cascades promoted by water
    Ivan Vilotijevic
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 317:1189-92. 2007
    ..This strategy offers a high-yielding route to the naturally occurring ladder core and highlights the likely importance of aqueous-medium effects in underpinning certain noteworthy enzymatic selectivities...
  94. ncbi Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis
    Yoshihiro Shichijo
    Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060 0810, Japan
    J Am Chem Soc 130:12230-1. 2008
    ..This is the first example of the enzymatic epoxide-opening reactions leading to a polyether natural product...
  95. ncbi Cleaning products and air fresheners: emissions and resulting concentrations of glycol ethers and terpenoids
    B C Singer
    Atmospheric Sciences Department, Environmental Energy Technologies Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Indoor Air 16:179-91. 2006
    Experiments were conducted to quantify emissions and concentrations of glycol ethers and terpenoids from cleaning product and air freshener use in a 50-m3 room ventilated at approximately 0.5/h...
  96. ncbi Overview of toxicological aspects of polybrominated diphenyl ethers: a flame-retardant additive in several consumer products
    Chris E Talsness
    Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Charite Universitatsmedizin Berlin, Garystr 5, 14195 Berlin, Germany
    Environ Res 108:158-67. 2008
    Polybrominated diphenyl ethers (PBDEs) are ubiquitous environmental contaminants due to their long half-life and widespread use as flame retardants in several consumer products, including plastics...
  97. ncbi Identification of hydroxylated polybrominated diphenyl ether metabolites in blood plasma from polybrominated diphenyl ether exposed rats
    Tina Malmberg
    Department of Environmental Chemistry, Stockholm University, SE 106 91 Stockholm, Sweden
    Environ Sci Technol 39:5342-8. 2005
    Polybrominated diphenyl ethers (PBDEs) are ubiquitous environmental contaminants due to their use as flame retardants. Similarly to PCBs, the PBDEs are metabolized to hydroxylated metabolites (OH-PBDEs) in mammals...
  98. ncbi Reductive debromination of polybrominated diphenyl ethers in anaerobic sediment and a biomimetic system
    John A Tokarz
    School of Civil Engineering, and Earth and Atmospheric Sciences, Purdue University, 550 Stadium Mall Drive, West Lafayette, Indiana 47907 2051, USA
    Environ Sci Technol 42:1157-64. 2008
    ..Given the very large BDE-209 burden already in sediments globally, it is important to determine whether this transformation is a significant source of lesser-brominated PBDEs to the environment...
  99. ncbi Polybrominated diphenyl ethers (PBDEs) in freshwater mussels and fish from Flanders, Belgium
    Adrian Covaci
    Toxicological Center, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
    J Environ Monit 7:132-6. 2005
    ..50) and most were statistically not significant (p > 0.05). This suggests that the exposure to contaminants arises from local sources possessing different signatures of PBDEs and organochlorine pollutants...
  100. ncbi Polybrominated diphenyl ethers (PBDEs) and their methoxylated derivatives in pike from Swedish waters with emphasis on temporal trends, 1967-2000
    A Kierkegaard
    Laboratory for Analytical Environmental Chemistry, Institute of Applied Environmental Research, Stockholm University, SE 106 91 Stockholm, Sweden
    Environ Pollut 130:187-98. 2004
    Temporal trends of five tetra- to hexabromodiphenyl ethers [BDE47, BDE99, BDE100, BDE153 and BDE154) and two methoxy-tetraBDEs [6-methoxy-2,2',4,4'- tetraBDE (6-MeO-BDE47) and 2'-methoxy-2,3',4,5'- tetraBDE (2'-MeO-BDE68)] in pike from ..
  101. ncbi Synthesis of vanillin ethers from 4-(bromomethyl) coumarins as anti-inflammatory agents
    Manjunath Ghate
    Post Graduate Department of Studies in Chemistry, Karnatak University, 580003, Dharwad, India
    Eur J Med Chem 38:297-302. 2003
    4-(Bromomethyl) coumarins 1 have been reacted with vanillins, 2 and 2A to obtain the corresponding ethers 3 and 5. Ethers 3 have been reacted with ethyl cyanoacetate to obtain the unsaturated esters 4...

Research Grants63

  1. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..GlycoMira is developing semi-synthetic glycosaminoglycan ethers (SAGEs) as safe and effective inflammation-modulating inhibitors of RAGE...
  2. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2013
    ..In Phase I, GlycoMira Therapeutics described a proprietary family of 5 kDa semi-synthetic glycosaminoglycan ethers (SAGEs), derived from sulfation and alkylation of hyaluronic acid (HA), that are intrinsically non-anticoagulant...
  3. Flame Retardant and Adverse Perinatal Outcome (FRAPO)
    Morgan R Peltier; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Polybromated Diphenyl Ethers (PBDEs) are one of the most prevalent organic pollutants due to their wide- spread use during the past 40 years as flame retardants, especially in the United States and ..
  4. Low level exposure to PBDEs: testing the hormetic and epigenetic hypotheses
    Lucio G Costa; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Polybrominated diphenyl ethers (PBDEs) are an important group of flame retardants, which have been widely used in a variety of consumer products...
  5. Novel Glycosaminoglycan Ethers for Prevention of Metastasis
    Alana L Welm; Fiscal Year: 2011
    ..developed a family of polyanionic, metabolically stabilized polysaccharides, the semi- synthetic glycosaminoglycan ethers (SAGEs)...
  6. Effect of Polybrominated Diphenal Ether Flame Retardant Exposure on Osteogenesis
    Deena J Small; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Polybrominated Diphenyl Ethers (PBDEs) flame retardants are considered a source of emerging environmental contaminants...
  7. Role of endocrine-disrupting chemicals and social stress on perinatal outcomes
    Ami R Zota; Fiscal Year: 2012
    ..goal of the candidate's Research Plan is to evaluate the independent effects of polybrominated diphenyl ethers (PBDEs) and psychosocial stress on thyroid hormone disruption and consequent perinatal outcomes among a population ..
  8. Children's Exposure to Flame Retardants: Effects on Thyroid Hormone Regulation
    Heather M Stapleton; Fiscal Year: 2012
    ..The flame retardant chemicals polybrominated diphenyl ethers (PBDEs) are persistent and ubiquitous pollutants, particularly in indoor environments...
  9. Novel Glycosaminoglycan Derivatives for Treatment of Bladder Inflammation
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..polysaccharides as safe and effective inflammation-modulating agents, the semi-synthetic glycosaminoglycan ethers (SAGEs)...
  10. PHAHs and Thyroid Cancer Risk in DoDSR Cohort
    Yawei Zhang; Fiscal Year: 2013
    ..Emerging evidence indicates that polybrominated diphenyl ethers (PBDEs) and other polyhalogenated aromatic hydrocarbons (PHAHs), including polychlorinated biphenyls (PCBs) and ..
  11. Deiodinase Activity as a Biomarker of Response to Brominated Flame Retardants
    Heather M Stapleton; Fiscal Year: 2012
    ..Until 2004, polybrominated diphenyl ethers (PBDEs) were used as the primary flame retardant additive in furniture in the United States...
  12. PCBs, PBDEs, Hearing Loss & Attention/Impulsivity: Mechanistic Studies in Animals
    Susan L Schantz; Fiscal Year: 2010
    ..exposure to contaminants found in fish-including polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and methyl mercury (MeHg)-on cognitive, motor and auditory function of children...
  13. Environmental Determinants of Autoimmunity among African Americans in Coastal SC
    Diane L Kamen; Fiscal Year: 2012
    ..First, high levels of certain highly persistent organic pollutants (POPs), specifically polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl acids (PFAAs), are found in local bottlenose dolphins and red drum, both sentinel ..
  14. Role of endocrine-disrupting chemicals and social stress on perinatal outcomes
    Ami R Zota; Fiscal Year: 2013
    ..The primary goal of my research plan is to evaluate the independent effects of polybrominated diphenyl ethers (PBDEs) and psychosocial stress on thyroid hormone disruption and consequent perinatal outcomes among a population ..
  15. A Total Synthesis of Gambierol Using an Epoxide-Opening Cascade Approach
    DENISE ANN COLBY; Fiscal Year: 2010
    ..The hallmark structural features of marine ladder polyethers include a series of syn/trans/syn fused cyclic ethers possessing C-C-O (carbon-carbon-oxygen) connectivity throughout the polyether framework, regardless of the ..
  16. Human Maternal/Fetal Exposures to PBDEs and their Metabolites During Development
    Tracey J Woodruff; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Our proposal tests the hypotheses that polybrominated diphenyl ethers (PBDEs) and their metabolites (OH- PBDEs) accumulate differently in the human fetal liver and placenta than in maternal serum, and ..
  17. Diabetes and Persistent Organic Pollutants
    MARY ELLEN TURYK; Fiscal Year: 2010
    ..as dioxins, polychlorinated biphenyls (PCBs), p,p'-diphenyldichloroethene (DDE), and polybrominated biphenyl ethers (PBDEs) are detectable in most of the US population...
  18. Longitudinal study of exposure to PBDEs and PFCs and child neurobehavior
    Kimberly Yolton; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl chemicals (PFCs, including perfluorooctane sulfonic acid [PFOS] and perfluorooctanoic acid [PFOA]) are persistent organic chemicals that were ..
  19. Center for Children's Environmental Health Research
    Brenda Eskenazi; Fiscal Year: 2013
    ..Center resources to obtain additional grants, ncluding resources to examine exposure to polybrominated diphenyl ethers (PBDEs) in this population...
  20. Epigenetic Interaction of MECP2 and Organic Pollutants in Neurodevelopment
    Janine LaSalle; Fiscal Year: 2009
    ..The widespread prevalence of POPs such as polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in the environment and their detection in human milk has prompted concern about in utero and early infant ..
  21. Health Effects of PCB Exposure from Contaminated Fish
    Susan L Schantz; Fiscal Year: 2010
    ..neuropsychological outcomes in adolescents exposed to polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), methyl mercury (MeHg) and other contaminants via consumption of fish from highly polluted waters in ..
  22. Prenatal exposure to a mixture of EDCs, maternal thyroid function and child neuro
    Megan K Horton; Fiscal Year: 2012
    ..provides information key to the current proposal including prenatal exposure levels to polybrominated diphenyl ethers (PBDEs) and perchlorate, an assessment of maternal thyroid function during the second trimester of pregnancy, and ..
  23. PBDE Body Burdens, House Dust Concentrations and Associations with Thyroid Hormon
    Lyndsey Darrow; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Polybrominated diphenyl ethers (PBDEs) are flame retardant compounds added to a wide range of consumer products...
  24. Autism Risk, Prenatal Environmental Exposures, and Pathophysiologic Markers
    Isaac N Pessah; Fiscal Year: 2013
    ..and having known neuro- or neurodevelopmental toxicity: pyrethroid pesticides and polybrominated diphenyl ethers (flame retardants)...
  25. ENVIRONMENT CHEMICALS AND GYNECOLOGIC HEALTH (ENDO STUDY)
    Matthew Peterson; Fiscal Year: 2009
    ..e., polychlorinated biphenyls, polybrominated diphenyl ethers, perfluorinated chemicals, and heavy metals) and lifestyle behaviors...
  26. Treatment of Bladder Pain by Novel Glycosaminoglycan Derivatives
    Siam Oottamasathien; Fiscal Year: 2013
    ..therapeutic standpoint, our group has developed novel patented compounds known as semi-synthetic glycosaminoglycan ethers (SAGEs) that attenuates the inflammatory effects of LL-37 by direct immune modulation and interference with mast ..
  27. Enhanced Liquid Core Waveguide Biosensor for PBDE Detection
    HEE JOO contact KIM; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Polybrominated diphenyl ethers (PBDEs) are common flame retardants used to reduce the risk of fire in a wide variety of products, such as mattresses, furniture, home electronics, textiles, upholstery ..
  28. Assessing maternal and fetal exposure to chemicals during the second trimester
    Tracey J Woodruff; Fiscal Year: 2012
    ..environmental contaminants in the US population - bisphenol A, phthalates, octylphenols, polybrominated diphenol ethers, perchlorate - raising the question of how people are being exposed...
  29. Prenatal exposure to a mixture of EDCs, maternal thyroid function and child neuro
    Megan K Horton; Fiscal Year: 2013
    ..provides information key to the current proposal including prenatal exposure levels to polybrominated diphenyl ethers (PBDEs) and perchlorate, an assessment of maternal thyroid function during the 2nd trimester of pregnancy, and ..
  30. Developmental Neuroendocrine Effects of PCBs and PBDEs: Parallels with ADHD
    RICHARD FIELD SEEGAL; Fiscal Year: 2010
    ..Polychlorinated biphenyls (PCBs) and, we suggest, polybrominated diphenyl ethers (PBDEs) induce similar deficits in attention and impulse control in developmentally exposed children, as well as ..
  31. Pre- and Postnatal PBDE Exposure, Thyroid Hormones, and Neurodevelopment
    JULIE BETH HERBSTMAN; Fiscal Year: 2013
    ..provided by applicant): Experimental evidence indicates that developmental exposure to polybrominated diphenyl ethers (PBDEs) disrupts thyroid hormone function and is neurotoxic, leading to deficits in learning and behavior...
  32. Mechanisms of Inflammation in Gestational Membranes
    Rita K Loch-Caruso; Fiscal Year: 2012
    ..lipopolysaccharide (LPS) as a model infectious stimulus and the environmental pollutants polybrominated diphenyl ethers (PBDEs) and p,p'-DDE as model noninfectious stimuli...
  33. SYNTHESIS OF PHOSPHATE ESTERS WITH IODINE--III REAGENTS
    GERALD KOSER; Fiscal Year: 1990
    ..The functionalization of ketones and beta-dicarbonyl compounds, silyl enol ethers, silyl ketene acetals, alkenes, conjugated dienes, alkynes and alkenoic acids with the iodine(III)-phosphates will ..
  34. Protecting the Health of Future Generations: Assessing and Preventing Exposures
    FRANK ARTHUR VON HIPPEL; Fiscal Year: 2013
    ..with the two Yupik villages of SLI to assess multiple exposure routes of two emerging EDCs-polybrominated diphenyl ethers (PBDEs) and perfluorinated compounds (PFCs)...
  35. Sixth International Symposium on Flame Retardants (BFR2013)
    Myrto Petreas; Fiscal Year: 2013
    ..The health relatedness of this conference is that the most commonly used flame retardants, polybrominated diphenyl ethers (PBDEs), have become ubiquitous in the environment and in humans in spite of efforts to limit their use in home ..
  36. Mechanism and Development of Catalysts for the Synthesis of Amines, Ethers, and S
    John F Hartwig; Fiscal Year: 2013
    This research program aims to develop catalytic synthetic methods that form amines, ethers and sulfides and to obtain precise mechanistic information for the design of new catalysts and for deducing relationships between emerging ..
  37. Synthetic Methodology to Access Novel Antivirals
    Mahesh K Lakshman; Fiscal Year: 2012
    ..The first is to delineate a novel method for the synthesis of hydroxybenzotriazole ethers using a novel mechanistic basis that essentially utilizes the benzotriazole moiety as an electrophile rather than ..
  38. Metal-Catalyzed Cross Coupling with N,O-Acetals and Acetals
    ABIGAIL GUTMANN DOYLE; Fiscal Year: 2013
    ..ubiquitous scaffolds in medicinal chemistry, biological chemistry, and glycobiology are ?-substituted amines and ethers. The goal of the proposed research program is to define a general and modular catalytic strategy that enables the ..
  39. Catalytic Stereoselective Olefin Metathesis Reactions
    Richard R Schrock; Fiscal Year: 2013
    ..Olefin metathesis catalysts will be developed that promote Z-selective cross-metathesis reactions of allylic ethers, epoxides, boronates, silanes as well as vinylbornates, dienes and 1,2-unsaturated carbonyls...
  40. Derivatives of Naltrexone as Opioid Pharmacotherapies
    Stephen M Husbands; Fiscal Year: 2010
    ..The target ligands are based on 14-(O)-ethers and -esters of the opioid antagonist naltrexone and on the orvinols...
  41. Vesicular monoamine transporter 2 as a mediator of PBDE neurotoxicity
    WILLIAM MICHAEL CAUDLE; Fiscal Year: 2012
    DESCRIPTION (provided by applicant) Concerns over the health risks associated with polybrominated diphenyl ethers (PBDEs) have been raised, especially given their ubiquitous environmental persistence and appreciable increases in their ..
  42. Robust New Chemistries for Heterocycles
    Andrew J Phillips; Fiscal Year: 2012
    ..are close relatives to kinase inhibitors, structures based on tetrahydroisoquinolines and homologs, polycyclic ethers, simple pyrans, and compounds that are suggested to be orthologs of complex polycyclic natural products...
  43. SITES OF ANESTHETIC ACTION IN INHIBITORY RECEPTORS
    Eric Greenblatt; Fiscal Year: 2002
    ..and other halogenated alkane VAs appear to have a different site of action in these receptors, when compared to VA ethers, such as isoflurane and enflurane, or alcohol. This is consistent with data supporting multiple sites of VA action...
  44. Assessment of Psychostimulant Addiction Risk Following Developmental PCB Exposure
    HELEN J SABLE; Fiscal Year: 2011
    ..deficits seen in PCB-exposed animals, and (3) Determine whether developmental exposure to polybrominated diphenyl ethers (PBDEs) results in changes in DA receptor expression and enhanced behavioral sensitization following ..
  45. DIETARY ETHER-LINKED LIPIDS AND N-3 FATTY ACIDS
    FRED SNYDER; Fiscal Year: 1993
    ..described in this application would be the first comprehensive dietary study ever conducted with the glyceryl ethers. Such information is important to obtain in view of the important role that potent alkyl type glycerolipids such ..
  46. POTENTIAL TUMOR OR ORGAN IMAGING AGENTS
    RAYMOND COUNSELL; Fiscal Year: 1993
    ..g. cholesterol-adrenal cortex, phospholipid ethers-tumors...
  47. NEW STRATEGIES FOR GLYCOCONJUGATE SYNTHESIS FROM ALKYNES
    Frank McDonald; Fiscal Year: 1999
    ..work with molybdenum pentacarbonyl- mediated cycloisomerization reactions of alkynyl alcohols to endocyclic enol ethers (glycals) and specific application of this chemistry to anti- AIDS nucleosides such as dideoxynucleosides, the ..
  48. ANESTHETIC TOXICITY--MECHANISMS AND PREVENTION
    Evan Kharasch; Fiscal Year: 1999
    ..free radicals which initiate lipid peroxidation, and catalyzes nephrotoxic fluoride ion release from fluorinated ethers. Specific human P450 isoforms responsible for anesthetic metabolism have been identified...
  49. BIOTOXICITY OF ACTIVATED OLEFINS
    Masato Koreeda; Fiscal Year: 1980
    ..g., vinyl chloride, trichloroethylene) and vinyl ethers (e.g...
  50. Enantioselective Thiourea-Catalyzed C-H Functionalization via Hydride Transfer
    DAVID JAMES HARDEE; Fiscal Year: 2013
    ..intermediates prone to a 1,5-hydride shift and subsequent cyclization for the enantioselective formation of cyclic ethers, important structural motifs in many natural products...
  51. Advanced Reproductive Age and Environmental Health
    Stephanie Engel; Fiscal Year: 2007
    ..Common endocrine altering (EA) environmental contaminants, including bisphenol A (BPA) and polybrominated diphenyl ethers (PBDEs), are possible human neurotoxins, immune modulators, reproductive toxicants, or may otherwise interfere ..
  52. PALLADIUM CATALYZED FORMATION OF ARYLAMINE AND ARYLETHER
    John Hartwig; Fiscal Year: 2000
    ..Concurrently, they will seek metal complexes that will catalyze the formation of aryl ethers from aryl halides and alkoxides. These methodological studies constitute the majority of this proposed work...
  53. Action of Novel Retinyl Ethers in Breast Cancer Control
    Brahma Sani; Fiscal Year: 2009
    ..We observed that a group of retinoids called retinyl ethers exhibit tissue-specific chemopreventive activity against carcinogen-induced mammary tumors in rats...
  54. New Methods for the Concise Synthesis of Bioactive Polycyclic Molecules
    REGAN JAMES THOMSON; Fiscal Year: 2013
    ..Our rationale for investigating silyl bis-enol ethers is that they can mediate the coupling of two different chemical fragments and simultaneously control the ..
  55. PTE-based drug for antibiotic-resistant anthrax
    Christopher Burns; Fiscal Year: 2005
    ..Our company has identified a promising class of synthetic compounds, pyridinium thio ethers (PTEs) that display strong bactericidal activity against a variety of Gram-positive bacteria, including B...
  56. CU-Catalyzed C(aryl)-N and C(aryl)-O Bond-forming Reactions
    RYAN ALTMAN; Fiscal Year: 2007
    ..frequently used in the pharmaceutical industry, especially by medicinal chemists, to form aromatic amines and aryl ethers, for the synthesis of potential drug targets...
  57. Applications of the Stereoretentive O and C Rearrangemen
    Tomislav Rovis; Fiscal Year: 2005
    ..The central approach of this research is to convert chiral vinyl ethers into the corresponding carbon-carbon bonds with retention of stereochemistry...
  58. BENZANNULATION APPROACH TO BIARYL ETHERS
    Michael Harmata; Fiscal Year: 2001
    ..the effective use of a benzannulation reaction in the synthesis of complex natural products containing biaryl ethers as an important structural feature...
  59. STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERS
    P Evans; Fiscal Year: 2002
    ..application of novel intramolecular acyl radical cyclizations to the synthesis of biologically important cyclic ethers. Although numerous methods exist for the synthesis of these compounds, the search for new methods with increased ..
  60. Crown ethers based photo take-apartable molecular hosts
    Andrei Kutateladze; Fiscal Year: 2001
    ..proposed research rational design will be applied to develop a series of novel molecular hosts comprised of crown ethers and/or cryptand units linked via our photolabile tethers...
  61. STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERS
    P Evans; Fiscal Year: 2006
    ..inter- and intramolecular etherification reactions for the construction of non-adjacent and fused polycyclic ethers. The bismuth-catalyzed etherification reactions exhibit remarkable catalytic activity and unusual chemoselectivity,..
  62. Colorimetric Breathalyzer for Dialysis Monitoring
    WILLIAM MCNAMARA; Fiscal Year: 2002
    ..Previous work has shown that this technology can detect and quantify vapors (including alcohols, amines, ethers, phosphines, phosphites, thioethers and thiols) at the sub-ppm (parts per million) level...
  63. Asymmetric Alkylation via Chiral Nucleophilic Catalysis
    ELIZABETH COLBY DAVIE; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): A strategy for the catalytic, asymmetric alkylation of silyl enol ethers and silyl ketene acetals via chiral nucleophilic catalysis is presented...