ethers

Summary

Top Publications

  1. pmc Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology
    P O Darnerud
    National Food Administration, Toxicology Division, Uppsala, Sweden
    Environ Health Perspect 109:49-68. 2001
  2. doi An overview of policies for managing polybrominated diphenyl ethers (PBDEs) in the Great Lakes basin
    Jessica Ward
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    Environ Int 34:1148-56. 2008
  3. pmc Tunable bifunctional silyl ether cross-linkers for the design of acid-sensitive biomaterials
    Matthew C Parrott
    Departments of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, United States
    J Am Chem Soc 132:17928-32. 2010
  4. ncbi Polybrominated diphenyl ethers and polychlorinated biphenyls in a marine foodweb of coastal Florida
    Boris Johnson-Restrepo
    Wadsworth Center, New York State Department of Health, USA
    Environ Sci Technol 39:8243-50. 2005
  5. doi Biaryl ethers as novel non-nucleoside reverse transcriptase inhibitors with improved potency against key mutant viruses
    Dai Shi Su
    Department of Medicinal Chemistry and Structural Biology, Merck Research Laboratory, P O Box 4, West Point, Pennsylvania 19486, USA
    J Med Chem 52:7163-9. 2009
  6. ncbi Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) in the abiotic environment: surface water and precipitation from Ontario, Canada
    Daisuke Ueno
    Department of Environmental Sciences, Faculty of Agriculture, Saga University, Honjo 1, Saga 840 8502, Japan
    Environ Sci Technol 42:1657-64. 2008
  7. ncbi Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea
    Novriyandi Hanif
    Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903 0213, Japan
    J Nat Prod 70:432-5. 2007
  8. ncbi Levels and distribution of polybrominated diphenyl ethers in water, surface sediments, and bivalves from the San Francisco Estuary
    Daniel R Oros
    San Francisco Estuary Institute, Oakland, California 94621, USA
    Environ Sci Technol 39:33-41. 2005
  9. ncbi Semiautomated high-throughput extraction and cleanup method for the measurement of polybrominated diphenyl ethers and polybrominated and polychlorinated biphenyls in breast milk
    Andreas Sjodin
    National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, Centers for Disease Control and Prevention, 4770 Buford Hwy NE Mail Stop F 17, Atlanta, Georgia 30341, USA
    Anal Chem 76:4508-14. 2004
  10. ncbi Dietary accumulation and metabolism of polybrominated diphenyl ethers by juvenile carp (Cyprinus carpio)
    Heather M Stapleton
    Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, Solomons, Maryland 20688, USA
    Environ Toxicol Chem 23:1939-46. 2004

Detail Information

Publications288 found, 100 shown here

  1. pmc Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology
    P O Darnerud
    National Food Administration, Toxicology Division, Uppsala, Sweden
    Environ Health Perspect 109:49-68. 2001
    Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in plastics (concentration, 5--30%) and in textile coatings...
  2. doi An overview of policies for managing polybrominated diphenyl ethers (PBDEs) in the Great Lakes basin
    Jessica Ward
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    Environ Int 34:1148-56. 2008
    ..Polybrominated diphenyl ethers (PBDEs), a class of brominated flame retardant, are among such chemicals, whose concentration in the Great Lakes ..
  3. pmc Tunable bifunctional silyl ether cross-linkers for the design of acid-sensitive biomaterials
    Matthew C Parrott
    Departments of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, United States
    J Am Chem Soc 132:17928-32. 2010
    ..These novel materials could be useful for numerous biomedical applications, including drug delivery, tissue repair, and general surgery...
  4. ncbi Polybrominated diphenyl ethers and polychlorinated biphenyls in a marine foodweb of coastal Florida
    Boris Johnson-Restrepo
    Wadsworth Center, New York State Department of Health, USA
    Environ Sci Technol 39:8243-50. 2005
    ..of marine mammals (dolphins) collected from Florida coastal waters were analyzed for polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) to evaluate biomagnification factors (BMF) of these contaminants in a ..
  5. doi Biaryl ethers as novel non-nucleoside reverse transcriptase inhibitors with improved potency against key mutant viruses
    Dai Shi Su
    Department of Medicinal Chemistry and Structural Biology, Merck Research Laboratory, P O Box 4, West Point, Pennsylvania 19486, USA
    J Med Chem 52:7163-9. 2009
    Biaryl ethers were recently reported as potent NNRTIs. Herein we disclose a detailed SAR study that led to the biaryl ether 6...
  6. ncbi Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) in the abiotic environment: surface water and precipitation from Ontario, Canada
    Daisuke Ueno
    Department of Environmental Sciences, Faculty of Agriculture, Saga University, Honjo 1, Saga 840 8502, Japan
    Environ Sci Technol 42:1657-64. 2008
    Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) have been identified as metabolites of PBDEs, and also as compounds of natural origin in the marine environment; however, there has only been very limited study of their presence in ..
  7. ncbi Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea
    Novriyandi Hanif
    Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903 0213, Japan
    J Nat Prod 70:432-5. 2007
    Four new (1-4) and 10 known polybrominated diphenyl ethers (5-14) have been isolated from the title sponge. The structures of the new entities were elucidated by interpretation of spectroscopic data and chemical transformations...
  8. ncbi Levels and distribution of polybrominated diphenyl ethers in water, surface sediments, and bivalves from the San Francisco Estuary
    Daniel R Oros
    San Francisco Estuary Institute, Oakland, California 94621, USA
    Environ Sci Technol 39:33-41. 2005
    Polybrominated diphenyl ethers (PBDEs) were found in water, surface sediments, and bivalve samples that were collected from the San Francisco Estuary in 2002...
  9. ncbi Semiautomated high-throughput extraction and cleanup method for the measurement of polybrominated diphenyl ethers and polybrominated and polychlorinated biphenyls in breast milk
    Andreas Sjodin
    National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, Centers for Disease Control and Prevention, 4770 Buford Hwy NE Mail Stop F 17, Atlanta, Georgia 30341, USA
    Anal Chem 76:4508-14. 2004
    A semiautomated extraction and cleanup method has been developed to measure eight polybrominated diphenyl ethers (PBDEs), 2,2',4,4',5,5'-hexabromobiphenyl (BB-153), and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153)...
  10. ncbi Dietary accumulation and metabolism of polybrominated diphenyl ethers by juvenile carp (Cyprinus carpio)
    Heather M Stapleton
    Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, Solomons, Maryland 20688, USA
    Environ Toxicol Chem 23:1939-46. 2004
    Polybrominated diphenyl ethers (PBDEs) are hydrophobic organic contaminants with properties and nomenclature similar to polychlorinated biphenyls (PCBs)...
  11. ncbi Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection
    Jelena M Janjic
    Department of Biological Sciences and Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, 4400 Fifth Ave, Pittsburgh, Pennsylvania 15213, USA
    J Am Chem Soc 130:2832-41. 2008
    ..The intracellular fluorescence signal is directly proportional to the 19F NMR signal and can be used to calibrate cell loading in vitro...
  12. ncbi Identification of antitumor activity of pyrazole oxime ethers
    Hyun Ja Park
    Bio organic Science Division, Korea Research Institute of Chemical Technology, PO Box 107, Yusong, Taejon 305 600, Republic of Korea
    Bioorg Med Chem Lett 15:3307-12. 2005
    ..A series of pyrazole oxime ether derivatives were prepared and examined as cytotoxic agents. In particular, 5-phenoxypyrazole was comparable to doxorubicin, while exhibiting very potent cytotoxicity against XF 498 and HCT15...
  13. pmc Oxidative cleavage of diverse ethers by an extracellular fungal peroxygenase
    Matthias Kinne
    From the Unit of Environmental Biotechnology, International Graduate School of Zittau, 02763 Zittau, Germany
    J Biol Chem 284:29343-9. 2009
    ..peroxygenase of Agrocybe aegerita catalyzed the H2O2-dependent cleavage of environmentally significant ethers, including methyl t-butyl ether, tetrahydrofuran, and 1,4-dioxane...
  14. pmc Hydroxylated metabolites of polybrominated diphenyl ethers in human blood samples from the United States
    Xinghua Qiu
    School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana, USA
    Environ Health Perspect 117:93-8. 2009
    A previous study from our laboratory showed that polybrominated diphenyl ethers (PBDEs) were metabolized to hydroxylated PBDEs (HO-PBDEs) in mice and that para-HO-PBDEs were the most abundant and, potentially, the most toxic metabolites.
  15. ncbi Screening of polybrominated diphenyl ethers in blue mussels, marine and freshwater sediments in Denmark
    J H Christensen
    National Environmental Research Institute, Department of Environmental Chemistry, Frederiksborgvej 399, 4000 Roskilde, Denmark
    J Environ Monit 3:543-7. 2001
    The first screening of polybrominated diphenyl ethers (PBDEs) in sediments and blue mussels (Mytilus edulis) collected in the Danish marine and freshwater environment is presented in this work...
  16. ncbi (E)- and (Z)-1,2,4-triazolylchromanone oxime ethers as conformationally constrained antifungals
    Saeed Emami
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, PO Box 48175 861, Sari, Iran
    Bioorg Med Chem 12:3971-6. 2004
    A series of 1,2,4-triazolylchromanone oxime ethers were synthesized and tested for in vitro antifungal activity...
  17. doi Passive sampling of glycol ethers and their acetates in indoor air
    H Plaisance
    Ecole des Mines de Douai, 941, rue Charles Bourseul, BP 838, Cedex, DOUAI 59508, France
    J Environ Monit 10:517-26. 2008
    ..the performances of a thermal desorbable radial diffusive sampler for the weekly measurement of eight glycol ethers in indoor air and described the results of an application of this method carried out as part of HABIT'AIR Nord - ..
  18. ncbi Comparative evaluation of three high-performance liquid chromatography-based Kow estimation methods for highly hydrophobic organic compounds: polybrominated diphenyl ethers and hexabromocyclododecane
    Stephen J Hayward
    Department of Chemical Engineering and Applied Chemistry and of Physical and Environmental Sciences, University of Toronto at Scarborough, 1265 Military Trail, Toronto, Ontario M1C 1A4, Canada
    Environ Toxicol Chem 25:2018-27. 2006
    ..speed, precision, and accuracy, with the latter judged by comparison with Kow values for polybrominated diphenyl ethers and polychlorinated naphthalenes as reported in the literature, a gradient elution combined with an exponential ..
  19. pmc Facile oxidative cleavage of 4-O-benzyl ethers with dichlorodicyanoquinone in rhamno- and mannopyranosides
    David Crich
    Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607 7061, USA
    J Org Chem 72:3581-4. 2007
    On exposure to dichlorodicyanoquinone in wet dichloromethane at room temperature, equatorial 4-O-benzyl ethers are removed with moderate selectivity in the presence of other benzyl ethers in glycopyranosides and glycothiopyranosides.
  20. ncbi Assessing the long-range transport potential of polybrominated diphenyl ethers: a comparison of four multimedia models
    Frank Wania
    Division of Physical Sciences, University of Toronto at Scarborough, 1265 Military Trail, Toronto, Ontario M1C 1A4, Canada
    Environ Toxicol Chem 22:1252-61. 2003
    ..literature search of environmentally relevant physical-chemical properties for nine polybrominated diphenyl ethers (PBDE), ranging from a monobrominated congener to the fully brominated decabromodiphenyl ether, were evaluated and ..
  21. doi Etherification of biodiesel-derived glycerol with ethanol for fuel formulation over sulfonic modified catalysts
    Juan A Melero
    Department of Chemical and Environmental Technology, ESCET, Universidad Rey Juan Carlos, c Tulipan s n, E 28933 Móstoles, Madrid, Spain
    Bioresour Technol 103:142-51. 2012
    ..glycerol with anhydrous ethanol over arenesulfonic acid-functionalized mesostructured silicas to produce ethyl ethers of glycerol that can be used as gasoline or diesel fuel biocomponents...
  22. ncbi C2-hydroxyglycosylation with glycal donors. Probing the mechanism of sulfonium-mediated oxygen transfer to glycal enol ethers
    Eiji Honda
    Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Am Chem Soc 124:7343-52. 2002
    ..investigations into this reaction revealed a novel process for sulfonium-mediated oxidation of glycal enol ethers in which the sulfoxide oxygen atom is stereoselectively transferred to the C2-position of the glycal...
  23. doi Biosynthesis of ethers: unusual or common natural events?
    Pablo Domínguez de María
    Process and Product Technology Department, AkzoNobel BV, Velperweg 76, Arnhem, The Netherlands
    Nat Prod Rep 27:370-92. 2010
    ..Depending on the compound and on the (micro) environment in which the reaction is performed, ethers are produced by very different (enzymatic) reactions, thus providing an impressive display of how Nature has ..
  24. ncbi A comparison between vital capacity induction and tidal breathing induction techniques for the induction of anesthesia and compound A production
    Shu Jie Liu
    Department of Anesthesiology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China
    Chin Med J (Engl) 123:2336-40. 2010
    ..The aim of this study was to compare them using sevoflurane with respect to induction time, complications of inhalation induction, and compound A production in adult patients...
  25. doi Selective, nickel-catalyzed hydrogenolysis of aryl ethers
    Alexey G Sergeev
    Department of Chemistry, University of Illinois, 600 South Matthews Avenue, Urbana, IL 61801, USA
    Science 332:439-43. 2011
    Selective hydrogenolysis of the aromatic carbon-oxygen (C-O) bonds in aryl ethers is an unsolved synthetic problem important for the generation of fuels and chemical feedstocks from biomass and for the liquefaction of coal...
  26. ncbi Effects of the water content of soda lime on compound A concentration in the anesthesia circuit in sevoflurane anesthesia
    H Bito
    Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan
    Anesthesiology 88:66-71. 1998
    ..This goal of this study was to determine if compound A concentrations can be reduced by using soda lime with water added...
  27. ncbi Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats
    E D Kharasch
    Department of Anesthesiology, University of Washington, Seattle, Washington 98195, USA
    Toxicol Appl Pharmacol 160:49-59. 1999
    ..The quantitative assay developed herein may provide a biomarker for FDVE exposure and relative metabolism via toxification and detoxifying pathways, applicable to animal and human investigations...
  28. doi Poly-ethers from Winogradskyella poriferorum: Antifouling potential, time-course study of production and natural abundance
    Swagatika Dash
    KAUST Global Collaborative Research, Division of Life Science, Hong Kong University of Science and Technology, HKSAR, China
    Bioresour Technol 102:7532-7. 2011
    ..Five poly-ethers were isolated and partially characterized based on nuclear magnetic resonance (NMR) spectroscopy and mass ..
  29. ncbi Aerobic biotransformation of polybrominated diphenyl ethers (PBDEs) by bacterial isolates
    Kristin R Robrock
    Department of Civil and Environmental Engineering, University of California, Berkeley, CA, USA
    Environ Sci Technol 43:5705-11. 2009
    Polybrominated diphenyl ethers (PBDEs) are flame retardants that have been used in consumer products and furniture for three decades...
  30. ncbi Role of renal cysteine conjugate beta-lyase in the mechanism of compound A nephrotoxicity in rats
    E D Kharasch
    Department of Anesthesiology, University of Washington, Seattle 98195, USA
    Anesthesiology 86:160-71. 1997
    ..Compound A nephrotoxicity has not been observed in humans. The authors tested the hypothesis that renal uptake of compound A S-conjugates and metabolism by renal cysteine conjugate beta-lyase mediate compound A nephrotoxicity in rats...
  31. ncbi Synthesis and biological evaluation of 12 allenic aromatic ethers
    San Yong Wang
    School of Chemistry and Chemical Engineering, Sun Yat Sen Zhongshan University, Guangzhou 510275, China
    Bioorg Med Chem Lett 17:2785-8. 2007
    Twelve allenic aromatic ethers, some of them are natural products isolated from the mangrove fungus Xylaria sp. 2508 in the South China Sea, were synthesized. Their antitumor activities against KB and KBv200 cells were determined...
  32. pmc Correlation of bilayer membrane cation transport and biological activity in alkyl-substituted lariat ethers
    W Matthew Leevy
    Departments of Chemistry and Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8103, St Louis, MO 63110, USA
    Org Biomol Chem 3:1647-52. 2005
    Dialkyldiaza-18-crown-6 lariat ethers having twin n-octyl, n-decyl, n-dodecyl, n-tetradecyl, n-hexadecyl, 1-oxodecyl and 1-oxododecyl side arms were prepared and studied...
  33. ncbi Four new aromatic allenic ethers from the fungus Xylaria sp. No. 2508
    San Yong Wang
    School of Chemistry and Chemical Engineering, Zhongshan University, Guangzhou, China
    Nat Prod Res 22:612-7. 2008
    Four new aromatic allenic ethers, (7E)-3-(4-buta-2,3-dienyloxy-3-methoxy-phenyl)-acrylic acid methyl ester (1), (7E)-3-[4-(4-buta-2,3-dienyloxy-benzyloxy)-phenyl]-acrylic acid methyl ester (2), 4-(4-buta-2,3-dienyloxy-benzyloxy)-benzoic ..
  34. doi Assessing the toxic effects of ethylene glycol ethers using Quantitative Structure Toxicity Relationship models
    Patricia Ruiz
    Computational Toxicology Methods Development Laboratory, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30333, USA
    Toxicol Appl Pharmacol 254:198-205. 2011
    ..The use of glycol ethers and their health effects have recently attracted the attention of international organizations such as the World ..
  35. pmc Formation of alkenes via degradation of tert-alkyl ethers and alcohols by Aquincola tertiaricarbonis L108 and Methylibium spp
    Franziska Schäfer
    Department of Environmental Microbiology, Helmholtz Centre for Environmental Research UFZ, Permoserstr 15, 04318 Leipzig, Germany
    Appl Environ Microbiol 77:5981-7. 2011
    ..The possible use of alkene formation as an easy-to-measure indicator of aerobic fuel oxygenate biodegradation in contaminated aquifers is discussed...
  36. ncbi Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists
    David L Gray
    Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, United States
    Bioorg Med Chem Lett 19:6604-7. 2009
    ..Several iterations of design, synthesis, and testing led to substituted piperidine diphenyl ethers which are potent NRIs with 5-HT1(A) partial agonist properties...
  37. doi Effects of hexabromocyclododecane and polybrominated diphenyl ethers on mRNA expression in chicken (Gallus domesticus) hepatocytes
    Doug Crump
    Environment Canada, National Wildlife Research Centre, 1125 Colonel By Drive, Ottawa, Ontario, Canada
    Toxicol Sci 106:479-87. 2008
    Hexabromocyclododecane (HBCD) and polybrominated diphenyl ethers (PBDEs) are additive flame retardants used in a wide range of consumer products...
  38. ncbi Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers
    N J Lawrence
    Department of Chemistry, UMIST, Manchester, UK
    Bioorg Med Chem Lett 11:51-4. 2001
    A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity...
  39. ncbi Synthesis of analogues of Eunicea gamma-cembranolides containing cyclic ethers via saponification
    A D Rodriguez
    Department of Chemistry, University of Puerto Rico, P O Box 23346, U P R Station, San Juan, Puerto Rico 00931 3346
    J Org Chem 66:648-58. 2001
    ..While it was shown that a variety of structural modifications are possible, these transformations led typically to nontoxic synthetic cembranoids...
  40. ncbi Distribution of polybrominated diphenyl ethers in human umbilical cord serum, paternal serum, maternal serum, placentas, and breast milk from Madrid population, Spain
    B Gómara
    Department of Instrumental Analysis and Environmental Chemistry, Institute of General Organic Chemistry, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain
    Environ Sci Technol 41:6961-8. 2007
    ..The presence of PBDEs in cord blood and placenta samples indicates that there is prenatal exposure of PBDEs, which could continue after birth via breast milk...
  41. ncbi Recent advances in structural research on ether lipids from archaea including comparative and physiological aspects
    Yosuke Koga
    Department of Chemistry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Biosci Biotechnol Biochem 69:2019-34. 2005
    ..In the last part of this review we discuss this problem...
  42. ncbi Isolation and characterization of polybrominated diphenyl ethers as inhibitors of microtubule assembly from the marine sponge Phyllospongia dendyi collected at Palau
    Hongwei Liu
    Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato ku, Tokyo 108 8477, Japan
    J Nat Prod 67:472-4. 2004
    Two new polybrominated diphenyl ethers (1 and 2) were isolated by bioassay-guided separations together with nine known compounds (3-11) from the marine sponge Phyllospongia dendyi collected from Palau...
  43. ncbi Polybrominated diphenyl ethers, perfluorinated compounds and chlorinated pesticides in swordfish (Xiphias gladius) from the Mediterranean Sea
    Simonetta Corsolini
    Dipartimento di Scienze Ambientali G Sarfatti, University of Siena, Via P A Mattioli, 4, I 53100 Siena, Italy
    Environ Sci Technol 42:4344-9. 2008
    ..The estimated daily ingestion of PBDEs and DDTs through diet was lower than the acceptable weekly intakes proposed by the World Health Organization...
  44. pmc Interactions of polybrominated diphenyl ethers with the aryl hydrocarbon receptor pathway
    A K Peters
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80176, Yalelaan 2, 3508 TD Utrecht, The Netherlands
    Toxicol Sci 92:133-42. 2006
    Polybrominated diphenyl ethers (PBDEs) are brominated flame retardants that have been in use as additives in various consumer products...
  45. ncbi GC/MS analysis of polybrominated diphenyl ethers in fish collected from the Inland Sea of Seto, Japan
    K Akutsu
    Osaka Prefectural Institute of Public Health, Japan
    Chemosphere 44:1325-33. 2001
    Development of an analytical method for polybrominated diphenyl ethers (PBDEs) in fish and their concentration in Japanese marine fish were investigated. Fish homogenate was extracted with diethyl ether/hexane (1 + 3)...
  46. ncbi Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers
    Ozden Ozel Güven
    Department of Chemistry, Zonguldak Karaelmas University, 67100 Zonguldak, Turkey
    Bioorg Med Chem Lett 17:2233-6. 2007
    In this study, a series of novel phenyl- and benzimidazole-substituted benzyl ethers were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Methicillin-resistant S...
  47. ncbi Serum concentrations of polybrominated diphenyl ethers (PBDEs) and polybrominated biphenyl (PBB) in the United States population: 2003-2004
    Andreas Sjodin
    Centers for Disease Control and Prevention, National Center for Environmental Health, 4770 Buford Highway NE, Atlanta, Georgia 30341, USA
    Environ Sci Technol 42:1377-84. 2008
    Polybrominated diphenyl ethers (PBDEs) and 2,2',4,4',5,5'-hexabromobiphenyl (BB-153) are chemicals known as brominated flame retardants...
  48. ncbi Polybrominated diphenyl ethers in house dust in Singapore
    Jing Tan
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117576, Singapore
    Chemosphere 66:985-92. 2007
    The use of polybrominated diphenyl ethers (PBDEs) as flame retardants in Singapore is not strictly regulated; therefore these compounds can be readily found in furniture, electronic devices, and building materials...
  49. ncbi Synthesis of new 2-naphthyl ethers and their protective activities against DNA damage induced by bleomycin-iron
    Bakr F Abdel-Wahab
    Applied Organic Chemistry Department, National Research Center, Dokki, Giza, Egypt
    Chem Pharm Bull (Tokyo) 57:1348-51. 2009
    ..Compound 2 showed the greatest protection against DNA damage, thus diminishing chromogen formation between the damaged DNA and thiobarbituric acid...
  50. ncbi Polybrominated diphenyl ethers, polychlorinated biphenyls and organochlorine pesticides in sediment cores from the Western Scheldt river (Belgium): analytical aspects and depth profiles
    A Covaci
    Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
    Environ Int 31:367-75. 2005
    ..PCBs) and selected organochlorinated pesticides (OCPs) and organobromines, such as polybrominated diphenyl ethers (PBDEs), in sediment samples was optimised using CRM 536 (PCBs in freshwater sediment)...
  51. ncbi Neonatal exposure to higher brominated diphenyl ethers, hepta-, octa-, or nonabromodiphenyl ether, impairs spontaneous behavior and learning and memory functions of adult mice
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Toxicol Sci 92:211-8. 2006
    Polybrominated diphenyl ethers (PBDEs), used as flame retardants, have been shown to be increasing in the environment and in human mother's milk...
  52. doi Ketone super silyl enol ethers in sequential reactions: diastereoselective generation of tertiary carbinols in one pot
    Matthew B Boxer
    Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA
    J Am Chem Soc 130:1580-2. 2008
  53. pmc Polybrominated diphenyl ethers (PBDEs) in U.S. mothers' milk
    Arnold Schecter
    University of Texas Health Sciences Center, School of Public Health, Dallas Regional Campus, Dallas, Texas 75390, USA
    Environ Health Perspect 111:1723-9. 2003
    ..S. population. Other routes of intake may also be significant...
  54. pmc Children show highest levels of polybrominated diphenyl ethers in a California family of four: a case study
    Douglas Fischer
    Oakland Tribune, Oakland, California 94612, USA
    Environ Health Perspect 114:1581-4. 2006
    Polybrominated diphenyl ethers (PBDEs), a major class of flame retardants, are ubiquitous environmental contaminants with particularly high concentrations in humans from the United States...
  55. ncbi Global assessment of polybrominated diphenyl ethers in farmed and wild salmon
    Ronald A Hites
    School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana 47405, USA
    Environ Sci Technol 38:4945-9. 2004
    ..In this paper, we extend these results to polybrominated diphenyl ethers (PBDEs) and show that farm-raised salmon have higher levels of these compounds than wild salmon...
  56. doi The biosynthesis of polyketide-derived polycyclic ethers
    Andrew R Gallimore
    Dept of Biochemistry, 80 Tennis Court Rd, Cambridge, CB2 1GA, UK
    Nat Prod Rep 26:266-80. 2009
    The biosynthetic pathways to polyketide-derived polycyclic ethers, in bacteria, plants and marine organisms, have, until now, tended to be considered separately...
  57. ncbi Temporal trends, congener patterns, and sources of octa-, nona-, and decabromodiphenyl ethers (PBDE) and hexabromocyclododecanes (HBCD) in Swiss lake sediments
    Martin Kohler
    Empa, Swiss Federal Laboratories for Materials Testing and Research, Uberlandstrasse 129, 8600 Dubendorf, Switzerland
    Environ Sci Technol 42:6378-84. 2008
    ....
  58. ncbi Total synthesis and complete assignment of the stereostructure of a cytotoxic bromotriterpene polyether (+)-aurilol
    Yoshiki Morimoto
    Department of Chemistry, Graduate School of Science, Osaka City University, Sumiyoshi ku, Osaka 558 8585, Japan
    J Am Chem Soc 127:5806-7. 2005
    ....
  59. ncbi Overview of toxicological aspects of polybrominated diphenyl ethers: a flame-retardant additive in several consumer products
    Chris E Talsness
    Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Charite Universitatsmedizin Berlin, Garystr 5, 14195 Berlin, Germany
    Environ Res 108:158-67. 2008
    Polybrominated diphenyl ethers (PBDEs) are ubiquitous environmental contaminants due to their long half-life and widespread use as flame retardants in several consumer products, including plastics...
  60. ncbi Polybrominated diphenyl ethers (PBDEs) in freshwater mussels and fish from Flanders, Belgium
    Adrian Covaci
    Toxicological Center, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
    J Environ Monit 7:132-6. 2005
    ..50) and most were statistically not significant (p > 0.05). This suggests that the exposure to contaminants arises from local sources possessing different signatures of PBDEs and organochlorine pollutants...
  61. ncbi Novel unsaturated sucrose ethers and their application as monomers
    Carina C Crucho
    REQUIMTE, Departamento de Química FCT, Universidade Nova de Lisboa, Quinta da Torre, 2829 516 Caparica, Portugal
    Molecules 13:762-70. 2008
    Novel unsaturated ethers were synthesised in good yields starting from sucrose,using a two-step mild and efficient procedure based on the Gassman method, which consists in forming a vinyl group by the elimination of ethanol from mixed ..
  62. ncbi Polybrominated diphenyl ether flame retardants in the U.S. population: current levels, temporal trends, and comparison with dioxins, dibenzofurans, and polychlorinated biphenyls
    Arnold Schecter
    University of Texas School of Public Health, Dallas Campus, 6011 Harry Hines Boulevard V8 112, Dallas, TX 75390, USA
    J Occup Environ Med 47:199-211. 2005
    ....
  63. ncbi Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation
    Steven M Johnson
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Med Chem 48:1576-87. 2005
    ..Of the library's 95 compounds, 31 were active inhibitors of TTR amyloid formation in vitro. The bisaryloxime ethers selectively stabilize the native tetrameric state of TTR over the dissociative transition state under ..
  64. ncbi Polybrominated diphenyl ethers and polychlorinated biphenyls in human adipose tissue from New York
    Boris Johnson-Restrepo
    Wadsworth Center, New York State Department of Health and Department of Environmental Health Sciences, State University of New York at Albany, Empire State Plaza, P O Box 509, Albany, New York 12201 0509, USA
    Environ Sci Technol 39:5177-82. 2005
    ..n=52) collected in New York City during 2003-2004 were analyzed for the presence of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs)...
  65. pmc Epoxide-opening cascades promoted by water
    Ivan Vilotijevic
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 317:1189-92. 2007
    ..This strategy offers a high-yielding route to the naturally occurring ladder core and highlights the likely importance of aqueous-medium effects in underpinning certain noteworthy enzymatic selectivities...
  66. ncbi Reductive debromination of polybrominated diphenyl ethers in anaerobic sediment and a biomimetic system
    John A Tokarz
    School of Civil Engineering, and Earth and Atmospheric Sciences, Purdue University, 550 Stadium Mall Drive, West Lafayette, Indiana 47907 2051, USA
    Environ Sci Technol 42:1157-64. 2008
    ..Given the very large BDE-209 burden already in sediments globally, it is important to determine whether this transformation is a significant source of lesser-brominated PBDEs to the environment...
  67. ncbi Polybrominated diphenyl ethers in the sediments of the Great Lakes. 4. Influencing factors, trends, and implications
    An Li
    School of Public Health, Department of Civil and Materials Engineering, University of Illinois at Chicago, USA
    Environ Sci Technol 40:7528-34. 2006
    ..16 locations in the five Laurentian Great Lakes, and each was analyzed for 10 congeners of polybrominated diphenyl ethers (PBDEs) as well as selected polychlorinated biphenyls (PCBs)...
  68. pmc Fate of pentabrominated diphenyl ethers in soil: abiotic sorption, plant uptake, and the impact of interspecific plant interactions
    Kevin E Mueller
    Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221 0006, USA
    Environ Sci Technol 40:6662-7. 2006
    Polybrominated diphenyl ethers (PBDEs) are potentially harmful and persistent environmental pollutants. Despite evidence that soils are a major sink for PBDEs, little is known regarding their behavior in this medium...
  69. ncbi Levels of polybrominated diphenyl ethers (PBDEs) in breast milk from central Taiwan and their relation to infant birth outcome and maternal menstruation effects
    How Ran Chao
    Department of Environmental Science and Engineering, National Pingtung University of Science and Technology, Neipu, Pingtung 912, Taiwan
    Environ Int 33:239-45. 2007
    In utero exposure to polybrominated diphenyl ethers (PBDEs) reduces the number of ovarian follicles in rat females and causes permanent effects on rat males...
  70. ncbi Gas-phase reactions of brominated diphenyl ethers with OH radicals
    Jonathan D Raff
    School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana 47405, USA
    J Phys Chem A 110:10783-92. 2006
    ..kinetics and mechanism of the reaction of OH radicals with diphenyl ether and seven polybrominated diphenyl ethers (PBDEs) with 1-2 bromines...
  71. ncbi Is house dust the missing exposure pathway for PBDEs? An analysis of the urban fate and human exposure to PBDEs
    Heather A Jones-Otazo
    Department of Geography, Centre for Urban Health Initiatives, University of Toronto, 100 St George Street, Toronto, Ontario, Canada
    Environ Sci Technol 39:5121-30. 2005
    ..Ingestion of dust can lead to almost 100-fold higher exposure than "average" for a toddler with a high dust intake rate living in a home in which PBDE concentrations are elevated...
  72. ncbi Microbial reductive debromination of polybrominated diphenyl ethers (PBDEs)
    Jianzhong He
    Department of Civil and Environmental Engineering, University of California at Berkeley, Berkeley, California 94720 1710, USA
    Environ Sci Technol 40:4429-34. 2006
    Polybrominated diphenyl ethers (PBDEs) are a class of widely used flame retardants that have recently been detected in environmental samples, diverse biota, human blood serum, and breast milk at exponentially increasing concentrations...
  73. ncbi Cleaning products and air fresheners: emissions and resulting concentrations of glycol ethers and terpenoids
    B C Singer
    Atmospheric Sciences Department, Environmental Energy Technologies Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Indoor Air 16:179-91. 2006
    Experiments were conducted to quantify emissions and concentrations of glycol ethers and terpenoids from cleaning product and air freshener use in a 50-m3 room ventilated at approximately 0.5/h...
  74. pmc Brevisamide: an unprecedented monocyclic ether alkaloid from the dinoflagellate Karenia brevis that provides a potential model for ladder-frame initiation
    Masayuki Satake
    Center for Marine Science, University of North Carolina, Wilmington, 5600 Marvin K Moss Lane, Wilmington, North Carolina 28409, USA
    Org Lett 10:3465-8. 2008
    ..This report describes the structure elucidation of brevisamide based on detailed MS and NMR spectral analysis, and the importance of this new compound in shedding light on the biogenesis of fused polyethers is discussed...
  75. ncbi Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis
    Yoshihiro Shichijo
    Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060 0810, Japan
    J Am Chem Soc 130:12230-1. 2008
    ..This is the first example of the enzymatic epoxide-opening reactions leading to a polyether natural product...
  76. ncbi Identification of hydroxylated polybrominated diphenyl ether metabolites in blood plasma from polybrominated diphenyl ether exposed rats
    Tina Malmberg
    Department of Environmental Chemistry, Stockholm University, SE 106 91 Stockholm, Sweden
    Environ Sci Technol 39:5342-8. 2005
    Polybrominated diphenyl ethers (PBDEs) are ubiquitous environmental contaminants due to their use as flame retardants. Similarly to PCBs, the PBDEs are metabolized to hydroxylated metabolites (OH-PBDEs) in mammals...
  77. ncbi Precursor-directed biosynthesis of stilbene methyl ethers in Escherichia coli
    Yohei Katsuyama
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    Biotechnol J 2:1286-93. 2007
    ..Furthermore, the OsPMT gene turned out to be useful in production of unnatural stilbene methyl ethers due to its rather relaxed substrate specificity; various carboxylic acids supplemented as precursors, such as p-..
  78. ncbi SiMe3-based homologation-epoxidation-cyclization strategy for ladder THP synthesis
    Timothy P Heffron
    Massachusetts Institute of Technology, Department of Chemistry, Cambridge, MA 02139, USA
    Org Lett 5:2339-42. 2003
    ..A tris-THP was synthesized in 18 total operations from commercial materials using this approach. [reaction: see text]..
  79. ncbi Atmospheric transport of polybrominated diphenyl ethers and polychlorinated biphenyls to the Baltic Sea
    Arnout F H ter Schure
    Chemical Ecology and Ecotoxicology, Department of Ecology, Lund University, Ecology Building, S 223 62 Lund, Sweden
    Environ Sci Technol 38:1282-7. 2004
    The atmospheric transport of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) was compared by measuring concentrations in air and deposition on an island located in the central basin of the Baltic Sea...
  80. ncbi Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations
    Ronald A Hites
    School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana 47405, USA
    Environ Sci Technol 38:945-56. 2004
    Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in many types of consumer products...
  81. ncbi Spatial distribution of polybrominated diphenyl ethers in southern Ontario as measured in indoor and outdoor window organic films
    Craig M Butt
    Department of Geography, University of Toronto, Toronto, Ontario, Canada M5S 3G3
    Environ Sci Technol 38:724-31. 2004
    ..Mean calculated air concentrations were 4.8 pg/m3 for outdoor and 42.1 pg/m3 for indoor urban sites, indicating that urban indoor air is a source of PBDEs to urban outdoor air and the outdoor regional environment...
  82. ncbi Temporal trend studies on tetra- and pentabrominated diphenyl ethers and hexabromocyclododecane in guillemot egg from the Baltic Sea
    Ulla Sellström
    Laboratory for Analytical Environmental Chemistry, Institute of Applied Environmental Research, Stockholm University, SE 106 91 Stockholm, Sweden
    Environ Sci Technol 37:5496-501. 2003
    Guillemot eggs from the Baltic Sea, sampled between 1969 and 2001, were analyzed for tetra- and pentabromodiphenyl ethers (2,2',4,4'-tetraBDE (BDE-47), 2,2',4,4',5-pentaBDE (BDE-99), and 2,2',4,4',6-pentaBDE (BDE-100)), and ..
  83. ncbi Polybrominated diphenyl ethers in breast milk from Uppsala County, Sweden
    Ylva Lind
    Swedish National Food Administration, PO Box 622, SE 751 26 Uppsala, Sweden
    Environ Res 93:186-94. 2003
    The breast milk concentrations of polybrominated diphenyl ethers (PBDEs; sum of five congeners: BDE-47, -99, -100, -153, and -154) were determined (by GC-ECD) in samples from 93 primiparous women collected from 1996 to 1999 in Uppsala ..
  84. ncbi Polybrominated diphenyl ethers in whitefish from Swiss lakes and farmed rainbow trout
    Markus Zennegg
    Swiss Federal Laboratories for Materials Testing and Research Empa, Laboratory of Organic Chemistry, Uberlandstrasse 129, 8600 Dubendorf, Switzerland
    Chemosphere 51:545-53. 2003
    A method for trace analysis of polybrominated diphenyl ethers (PBDE) in fish based on gas chromatography/electron ionization high resolution mass spectrometry (GC/EI-HRMS) was developed, and levels of PBDE were determined in whitefish (..
  85. ncbi Synthesis of vanillin ethers from 4-(bromomethyl) coumarins as anti-inflammatory agents
    Manjunath Ghate
    Post Graduate Department of Studies in Chemistry, Karnatak University, 580003, Dharwad, India
    Eur J Med Chem 38:297-302. 2003
    4-(Bromomethyl) coumarins 1 have been reacted with vanillins, 2 and 2A to obtain the corresponding ethers 3 and 5. Ethers 3 have been reacted with ethyl cyanoacetate to obtain the unsaturated esters 4...
  86. ncbi Polybrominated diphenyl ethers (PBDEs) in foodstuffs: human exposure through the diet
    A Bocio
    Laboratory of Toxicology and Environmental Health, School of Medicine, Rovira i Virgili University, 43201 Reus, Spain
    J Agric Food Chem 51:3191-5. 2003
    Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in a variety of materials, including synthetic polymers and textiles...
  87. ncbi Congener-specific accumulation and food chain transfer of polybrominated diphenyl ethers in two arctic food chains
    Hans Wolkers
    Norwegian Polar Institute, N 9296 Tromsø, Norway
    Environ Sci Technol 38:1667-74. 2004
    Congener-specific accumulation and prey to predator transfer of 22 polybrominated diphenyl ethers (PBDEs) were assessed in polar cod, ringed seal, polar bear, and beluga whale...
  88. ncbi Polybrominated diphenyl ethers (PBDEs) and their methoxylated derivatives in pike from Swedish waters with emphasis on temporal trends, 1967-2000
    A Kierkegaard
    Laboratory for Analytical Environmental Chemistry, Institute of Applied Environmental Research, Stockholm University, SE 106 91 Stockholm, Sweden
    Environ Pollut 130:187-98. 2004
    Temporal trends of five tetra- to hexabromodiphenyl ethers [BDE47, BDE99, BDE100, BDE153 and BDE154) and two methoxy-tetraBDEs [6-methoxy-2,2',4,4'- tetraBDE (6-MeO-BDE47) and 2'-methoxy-2,3',4,5'- tetraBDE (2'-MeO-BDE68)] in pike from ..
  89. ncbi New clerodane diterpenoid and flavonol-3-methyl ethers from Dodonaea viscosa
    M Abdel-Mogib
    Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
    Pharmazie 56:830-1. 2001
    ..Sapindaceae) afforded beta-sitosterol, stigmasterol, the flavone acacetin-7-methyl ether, the flavonol-3-methyl ethers 4',5,7-trihydroxy-3,6-dimethoxyflavone and penduletin, as well as a new clerodane diterpenoid which was identified ..
  90. pmc Brevenal is a natural inhibitor of brevetoxin action in sodium channel receptor binding assays
    Andrea J Bourdelais
    Center for Marine Science, University of North Carolina at Wilmington, Wilmington, North Carolina 28409, USA
    Cell Mol Neurobiol 24:553-63. 2004
    ..5. Brevenal may serve as a model compound for the development of therapeutics to prevent or reverse intoxication in red tide exposures...
  91. ncbi Synthesis of heterocyclic enol ethers and their use as group 2 metabotropic glutamate receptor antagonists
    S Kolczewski
    Pharma Division, Preclinical CNS Research, F Hoffmann La Roche Ltd, Basel
    Bioorg Med Chem Lett 9:2173-6. 1999
    Heterocyclic enol ethers of type 1 were studied with respect to the inhibition of 1S,3R-ACPD (10 microM)-stimulated GTP gamma35S binding on rat mGluR2 transfected cell membranes...
  92. ncbi Electron transfer initiated heterogenerative cascade cyclizations: polyether synthesis under nonacidic conditions
    V Satish Kumar
    Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Org Lett 4:2489-92. 2002
    ..Both oligotetrahydrofuran and tetrahydropyran structures can be prepared by altering substrate topography...
  93. pmc Different levels of polybrominated diphenyl ethers (PBDEs) and chlorinated compounds in breast milk from two U.K. Regions
    Olga I Kalantzi
    Department of Environmental Science, Institute of Environmental and Natural Sciences, Lancaster University, Lancaster, United Kingdom
    Environ Health Perspect 112:1085-91. 2004
    ..Key words: breast milk, flame retardants, gas chromatography-mass spectrometry, milk-fat extracts, organochlorines, PBDE-47, persistent contaminants, polybrominated diphenyl ethers, polychlorinated biphenyls, United Kingdom.
  94. ncbi Determination of fuel dialkyl ethers and BTEX in water using headspace solid-phase microextraction and gas chromatography-flame ionization detection
    Idoia Arambarri
    Departamento de Quimica Aplicada, Facultad de Quimica, Universidad del Pais Vasco, Apdo 1072, 20080 San Sebastian, Spain
    J Chromatogr A 1033:193-203. 2004
    ..An extraction time of 10 min was enough to extract the ethers and BTEX. The relative standard deviation (R.S.D.) for the procedure varied from 2.6 (benzene) to 8...
  95. ncbi Dispersive liquid-liquid microextraction followed by reversed phase-high performance liquid chromatography for the determination of polybrominated diphenyl ethers at trace levels in landfill leachate and environmental water samples
    Yanyan Li
    School of Environmental Science and Public Health, Wenzhou Medical College, Wenzhou 325035, China
    Anal Chim Acta 615:96-103. 2008
    ..microextraction (DLLME), has been developed for the extraction and preconcentration of polybrominated diphenyl ethers (PBDEs) in water samples...
  96. ncbi Polybrominated diphenyl ethers in the sediments of the Great Lakes. 1. Lake Superior
    Wenlu Song
    School of Public Health, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Environ Sci Technol 38:3286-93. 2004
    ..Soxhlet-extracted and cleaned up by silica gel fractionation, and the concentrations of 10 polybrominated diphenyl ethers (PBDEs) and 19 polychlorinated biphenyls (PCBs) were measured by GC-MS in SIM mode...
  97. ncbi Chromatographic and ionization properties of polybrominated diphenyl ethers using GC/high-resolution MS with metastable atom bombardment and electron impact ionization
    Michael G Ikonomou
    Contaminants Science Section, Institute of Ocean Sciences, Fisheries and Oceans Canada, Sidney, British Columbia
    Anal Chem 74:5263-72. 2002
    ..A significantly higher level of predictability was obtained for the MAB-N2 response model than for EI...
  98. pmc Asymmetric synthesis of primary amines via the spiroborate-catalyzed borane reduction of oxime ethers
    Xiaogen Huang
    Department of Chemistry, University of Puerto Rico Humacao, CUH Station, Humacao, Puerto Rico 00791
    Org Lett 9:1793-5. 2007
    reaction: see text] The enantioselective borane reduction of O-benzyloxime ethers to primary amines was studied under catalytic conditions using the spiroborate esters 5-10 derived from nonracemic 1,2-amino alcohols and ethylene glycol...
  99. ncbi Synthesis of densely functionalised arenes using [2 + 2 + 2] cycloaddition reactions
    Jonathan Clayden
    School of Chemistry, The University of Manchester, Oxford Road, Manchester, UK
    Org Biomol Chem 5:1028-30. 2007
    Rh(I)-catalysed [2 + 2 + 2] cycloaddition allows the synthesis of aryl ethers and diaryl methanes containing a high degree of steric hindrance from relatively simple diyne and alkyne precursors...
  100. ncbi Synthesis and biological studies of novel 2-aminoalkylethers as potential antiarrhythmic agents for the conversion of atrial fibrillation
    Bertrand Plouvier
    Cardiome Pharma Corporation, 6190 Agronomy Road, 6th Floor, Vancouver, British Columbia V6T 1Z3
    J Med Chem 50:2818-41. 2007
    ....
  101. ncbi Tuning of the prolyl trans/cis-amide rotamer population by use of C-glucosylproline hybrids
    Neil W Owens
    Department of Chemistry, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
    J Org Chem 72:4635-43. 2007
    ..Overall, our GlcProH demonstrates variation in Kt/c through tuning of the carbohydrate scaffold: a new concept in proline peptidomimetics...

Research Grants79

  1. Effect of Polybrominated Diphenal Ether Flame Retardant Exposure on Osteogenesis
    Deena J Small; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Polybrominated Diphenyl Ethers (PBDEs) flame retardants are considered a source of emerging environmental contaminants...
  2. SYNTHESIS OF PHOSPHATE ESTERS WITH IODINE--III REAGENTS
    GERALD KOSER; Fiscal Year: 1990
    ..The functionalization of ketones and beta-dicarbonyl compounds, silyl enol ethers, silyl ketene acetals, alkenes, conjugated dienes, alkynes and alkenoic acids with the iodine(III)-phosphates will ..
  3. Catalytic Methods for Carbon-Carbon Bond Formation
    F Toste; Fiscal Year: 2006
    ..Use of other enolate equivalents, such as silyl enol ethers and enamines is also proposed...
  4. Catalytic Methods for Carbon-Carbon Bond Formation
    F Toste; Fiscal Year: 2005
    ..Use of other enolate equivalents, such as silyl enol ethers and enamines is also proposed...
  5. Catalytic Methods for Carbon-Carbon Bond Formation
    F Toste; Fiscal Year: 2007
    ..Use of other enolate equivalents, such as silyl enol ethers and enamines is also proposed...
  6. Catalytic Methods for Carbon-Carbon Bond Formation
    F Toste; Fiscal Year: 2009
    ..Use of other enolate equivalents, such as silyl enol ethers and enamines is also proposed...
  7. Measuring Human Exposure to PBDEs
    Thomas Webster; Fiscal Year: 2009
    Polybrominated diphenyl ethers (PBDEs) are commonly used as fire retardants in consumer products such as electronics and furniture containing polyurethane foam...
  8. Measuring Human Exposure to PBDEs
    Thomas Webster; Fiscal Year: 2009
    Polybrominated diphenyl ethers (PBDEs) are commonly used as fire retardants in consumer products such as electronics and furniture containing polyurethane foam...
  9. Measuring Human Exposure to PBDEs
    Thomas F Webster; Fiscal Year: 2010
    Polybrominated diphenyl ethers (PBDEs) are commonly used as fire retardants in consumer products such as electronics and furniture containing polyurethane foam...
  10. ALCOHOL METABOLISM--ROLE OF P-450 OXYGENASES
    Minor Coon; Fiscal Year: 1993
    ..compounds, including ethanol and other alcohols, ketones, nitrosamines, and halogenated alkanes, alkanes, and ethers, as well as aromatic compounds, almost no information is yet available with P-450 IIE2...
  11. The Charge Study: Childhood Autism Risks from Genetics and the Environment
    Irva Hertz Picciotto; Fiscal Year: 2009
    ..and laboratory analysis of dust samples from the home to obtain historical measures of polybrominated diphenyl ethers (PBDEs) and other home environmental exposures that cover the perinatal period, (b) expands the chemicals for ..
  12. ALCOHOL METABOLISM--ROLE OF P-450 OXYGENASES
    Minor Coon; Fiscal Year: 1992
    ..compounds, including ethanol and other alcohols, ketones, nitrosamines, and halogenated alkanes, alkanes, and ethers, as well as aromatic compounds, almost no information is yet available with P-450 IIE2...
  13. EARLY TRANSITION METAL CATALYSTS FOR ORGANIC SYNTHESIS
    STEPHEN BUCHWALD; Fiscal Year: 1992
    ..aldehydes; 7) The asymmetric reduction of imines to amines; 8) The enantioselective reductions of ketones to silyl ethers; 9) The conversion of oxindoles to indoles and butenolides to furans; 10) The conversion of carboxylic acids to ..
  14. Late Metal-Catalyzed Carbon-Carbon Bond Forming Reaction of Enolate Nucleophiles
    John Hartwig; Fiscal Year: 2009
    ..nucleophiles during the past grant period to an iridium-catalyzed, enantioselective allylation of silyl enol ethers. The iridium- catalyzed reaction is unusual because it creates a new stereocenter at the allyl electrophile and ..
  15. HUMAN ANESTHETIC TOXICITY--MECHANISMS AND PREVENTION
    Evan Kharasch; Fiscal Year: 1992
    ..radicals which initiate lipid peroxidation, and is responsible for releasing free fluoride ion from fluorinated ethers. The central hypothesis to be tested in this proposal is that specific isozymes of human cytochrome P450 are ..
  16. Late Metal-Catalyzed Carbon-Carbon Bond Forming Reaction of Enolate Nucleophiles
    John Hartwig; Fiscal Year: 2007
    ..nucleophiles during the past grant period to an iridium-catalyzed, enantioselective allylation of silyl enol ethers. The iridium- catalyzed reaction is unusual because it creates a new stereocenter at the allyl electrophile and ..
  17. Late Metal-Catalyzed Carbon-Carbon Bond Forming Reaction of Enolate Nucleophiles
    John F Hartwig; Fiscal Year: 2010
    ..nucleophiles during the past grant period to an iridium-catalyzed, enantioselective allylation of silyl enol ethers. The iridium- catalyzed reaction is unusual because it creates a new stereocenter at the allyl electrophile and ..
  18. SITES OF ANESTHETIC ACTION IN INHIBITORY RECEPTORS
    Eric Greenblatt; Fiscal Year: 2002
    ..and other halogenated alkane VAs appear to have a different site of action in these receptors, when compared to VA ethers, such as isoflurane and enflurane, or alcohol. This is consistent with data supporting multiple sites of VA action...
  19. SITES OF ANESTHETIC ACTION IN INHIBITORY RECEPTORS
    Eric Greenblatt; Fiscal Year: 2000
    ..and other halogenated alkane VAs appear to have a different site of action in these receptors, when compared to VA ethers, such as isoflurane and enflurane, or alcohol. This is consistent with data supporting multiple sites of VA action...
  20. SITES OF ANESTHETIC ACTION IN INHIBITORY RECEPTORS
    Eric Greenblatt; Fiscal Year: 2001
    ..and other halogenated alkane VAs appear to have a different site of action in these receptors, when compared to VA ethers, such as isoflurane and enflurane, or alcohol. This is consistent with data supporting multiple sites of VA action...
  21. NEW REACTIONS OF ALKYL AZIDES WITH KETONES
    JEFFREY AUBE; Fiscal Year: 1993
    ..In addition, aldehydes, thioketones, acetals and ketals, and enol ethers can in principle give intermediates that could react in analogous ways and expand the range of the keto/azide ..
  22. Advanced Reproductive Age and Environmental Health
    Stephanie Engel; Fiscal Year: 2006
    ..Common endocrine altering (EA) environmental contaminants, including bisphenol A (BPA) and polybrominated diphenyl ethers (PBDEs), are possible human neurotoxins, immune modulators, reproductive toxicants, or may otherwise interfere ..
  23. MANGANESE (III) BASED OXIDATIVE FREE RADICAL CYCLIZATION
    BARRY SNIDER; Fiscal Year: 1993
    ..11) probes for the reversibility of radical cyclization, (12) oxidative cyclization of unsaturated silyl enol ethers, (13) oxidative cyclization of unsaturated silyloxycyclopropanes, and (14) conversion of other radicals to alkenes ..
  24. MANGANESE (III) BASED OXIDATIVE FREE RADICAL CYCLIZATION
    BARRY SNIDER; Fiscal Year: 1991
    ..11) probes for the reversibility of radical cyclization, (12) oxidative cyclization of unsaturated silyl enol ethers, (13) oxidative cyclization of unsaturated silyloxycyclopropanes, and (14) conversion of other radicals to alkenes ..
  25. SITES OF ANESTHETIC ACTION IN INHIBITORY RECEPTORS
    Eric Greenblatt; Fiscal Year: 1999
    ..and other halogenated alkane VAs appear to have a different site of action in these receptors, when compared to VA ethers, such as isoflurane and enflurane, or alcohol. This is consistent with data supporting multiple sites of VA action...
  26. POTENTIAL TUMOR OR ORGAN IMAGING AGENTS
    RAYMOND COUNSELL; Fiscal Year: 1993
    ..g. cholesterol-adrenal cortex, phospholipid ethers-tumors...
  27. Diabetes and Persistent Organic Pollutants
    MARY ELLEN TURYK; Fiscal Year: 2010
    ..as dioxins, polychlorinated biphenyls (PCBs), p,p'-diphenyldichloroethene (DDE), and polybrominated biphenyl ethers (PBDEs) are detectable in most of the US population...
  28. Diabetes and Persistent Organic Pollutants
    Mary Turyk; Fiscal Year: 2009
    ..as dioxins, polychlorinated biphenyls (PCBs), p,p'-diphenyldichloroethene (DDE), and polybrominated biphenyl ethers (PBDEs) are detectable in most of the US population...
  29. PHTHALOCYANINE PHOTODYNAMIC THERAPY OF SKIN TUMORS
    Hasan Mukhtar; Fiscal Year: 1990
    ..Unfortunately, the porphyrin mixture dihematoporphyrin ethers known as Photofrin II suitable for photodynamic therapy possesses several intrinsic disadvantages which led to a ..
  30. DIETARY ETHER-LINKED LIPIDS AND N-3 FATTY ACIDS
    FRED SNYDER; Fiscal Year: 1991
    ..described in this application would be the first comprehensive dietary study ever conducted with the glyceryl ethers. Such information is important to obtain in view of the important role that potent alkyl type glycerolipids such ..
  31. ANESTHETIC TOXICITY--MECHANISMS AND PREVENTION
    Evan Kharasch; Fiscal Year: 1999
    ..free radicals which initiate lipid peroxidation, and catalyzes nephrotoxic fluoride ion release from fluorinated ethers. Specific human P450 isoforms responsible for anesthetic metabolism have been identified...
  32. CYTOCHROME P450IIEL: FUNCTIONS & MECHANISMS OF INDUCTION
    Chung Yang; Fiscal Year: 1990
    ..It is a key enzyme in the metabolism of acetone, N-nitrosodimethylamine, ethers, alkanes, CCl4, enflurane, and other xenobiotics...
  33. Effect of nutritional status on MRP2 expression and biliary excretion of bispheno
    ANGELA SLITT; Fiscal Year: 2009
    ..fasting, and CR induce MRP via Sirt1, and 4) RES, fasting, and CR affect bisphenol A and polybrominated diphenyl ethers (PBDE) disposition in mice...
  34. Effect of nutritional status on MRP2 expression and biliary excretion of bispheno
    ANGELA SLITT; Fiscal Year: 2009
    ..fasting, and CR induce MRP via Sirt1, and 4) RES, fasting, and CR affect bisphenol A and polybrominated diphenyl ethers (PBDE) disposition in mice...
  35. Effect of nutritional status on MRP2 expression and biliary excretion of bispheno
    Angela L Slitt; Fiscal Year: 2010
    ..fasting, and CR induce MRP via Sirt1, and 4) RES, fasting, and CR affect bisphenol A and polybrominated diphenyl ethers (PBDE) disposition in mice...
  36. Mechanisms of Inflammation in Gestational Membranes
    RITA KAREN LOCH CARUSO; Fiscal Year: 2010
    ..lipopolysaccharide (LPS) as a model infectious stimulus and the environmental pollutants polybrominated diphenyl ethers (PBDEs) and p,p'-DDE as model noninfectious stimuli...
  37. Mechanisms of Inflammation in Gestational Membranes
    Rita Loch Caruso; Fiscal Year: 2009
    ..lipopolysaccharide (LPS) as a model infectious stimulus and the environmental pollutants polybrominated diphenyl ethers (PBDEs) and p,p'-DDE as model noninfectious stimuli...
  38. REACTIVE INTERMEDIATES IN TOXICANT ACTION
    JOHN CASIDA; Fiscal Year: 1990
    ..Therefore potential hazards from such products formed from other nitrodiphenyl ethers and chlordimeform and of imines from glyphosate are assessed...
  39. Enhanced Liquid Core Waveguide Biosensor for PBDE Detection
    HEE JOO contact KIM; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Polybrominated diphenyl ethers (PBDEs) are common flame retardants used to reduce the risk of fire in a wide variety of products, such as mattresses, furniture, home electronics, textiles, upholstery ..
  40. PBDE Body Burdens, House Dust Concentrations and Associations with Thyroid Hormon
    Dana Boyd Barr; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Polybrominated diphenyl ethers (PBDEs) are flame retardant compounds added to a wide range of consumer products...
  41. POLYETHER IONOPHORES: SYNTHESIS OF X537A AND ANALOGS
    ROBERT IRELAND; Fiscal Year: 1980
    ..appear to be nature's equivalents of crown ethers, and through their complexation of cations or amines, the inonophores from lipid soluble complexes of these polar ..
  42. Environmental Determinants of Autoimmunity among African Americans in Coastal SC
    Diane L Kamen; Fiscal Year: 2010
    ..First, high levels of certain highly persistent organic pollutants (POPs), specifically polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl acids (PFAAs), are found in local bottlenose dolphins and red drum, both sentinel ..
  43. C-H Bond Functionalization in Organic Synthesis
    MELANIE SANFORD; Fiscal Year: 2007
    ..use of organic substrates that contain appropriate chelating functional groups (for example oximes, heterocycles, ethers, amides and amines)...
  44. Environmental Determinants of Autoimmunity among African Americans in Coastal SC
    Diane L Kamen; Fiscal Year: 2010
    ..First, high levels of certain highly persistent organic pollutants (POPs), specifically polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl acids (PFAAs), are found in local bottlenose dolphins and red drum, both sentinel ..
  45. Center for Children's Environmental Health Research
    Brenda Eskenazi; Fiscal Year: 2010
    ..Center resources to obtain additional grants, ncluding resources to examine exposure to polybrominated diphenyl ethers (PBDEs) in this population...
  46. Center for Children's Environmental Health Research
    Brenda Eskenazi; Fiscal Year: 2009
    ..Center resources to obtain additional grants, ncluding resources to examine exposure to polybrominated diphenyl ethers (PBDEs) in this population...
  47. Environmental Determinants of Autoimmunity among African Americans in Coastal SC
    Diane Kamen; Fiscal Year: 2009
    ..First, high levels of certain highly persistent organic pollutants (POPs), specifically polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl acids (PFAAs), are found in local bottlenose dolphins and red drum, both sentinel ..
  48. C-H Bond Functionalization in Organic Synthesis
    MELANIE SANFORD; Fiscal Year: 2009
    ..use of organic substrates that contain appropriate chelating functional groups (for example oximes, heterocycles, ethers, amides and amines)...
  49. NEW METHODS FOR THE SYNTHESIS OF ALKALOIDS
    JEFFREY AUBE; Fiscal Year: 2001
    ..reactions of ketones with hydroxyalkyl azides (the Boyer reaction) and the manipulation of the resulting iminium ethers. Specifically, this entails the continued exploration of asymmetric lactam synthesis by (a) experimental and (b) ..
  50. NEW METHODS FOR THE SYNTHESIS OF ALKALOIDS
    JEFFREY AUBE; Fiscal Year: 2002
    ..reactions of ketones with hydroxyalkyl azides (the Boyer reaction) and the manipulation of the resulting iminium ethers. Specifically, this entails the continued exploration of asymmetric lactam synthesis by (a) experimental and (b) ..
  51. NEW METHODS FOR THE SYNTHESIS OF ALKALOIDS
    JEFFREY AUBE; Fiscal Year: 2004
    ..reactions of ketones with hydroxyalkyl azides (the Boyer reaction) and the manipulation of the resulting iminium ethers. Specifically, this entails the continued exploration of asymmetric lactam synthesis by (a) experimental and (b) ..
  52. C-H Bond Functionalization in Organic Synthesis
    MELANIE SANFORD; Fiscal Year: 2005
    ..use of organic substrates that contain appropriate chelating functional groups (for example oximes, heterocycles, ethers, amides and amines)...
  53. C-H Bond Functionalization in Organic Synthesis
    MELANIE SANFORD; Fiscal Year: 2009
    ..use of organic substrates that contain appropriate chelating functional groups (for example oximes, heterocycles, ethers, amides and amines)...
  54. C-H Bond Functionalization in Organic Synthesis
    MELANIE SANFORD; Fiscal Year: 2006
    ..use of organic substrates that contain appropriate chelating functional groups (for example oximes, heterocycles, ethers, amides and amines)...
  55. C-H Bond Functionalization in Organic Synthesis
    MELANIE SANFORD; Fiscal Year: 2007
    ..use of organic substrates that contain appropriate chelating functional groups (for example oximes, heterocycles, ethers, amides and amines)...
  56. POTENTIAL TUMOR OR ORGAN IMAGING AGENTS
    RAYMOND COUNSELL; Fiscal Year: 1991
    ..g. cholesterol-adrenal cortex, phospholipid ethers-tumors...
  57. INTRAMOLECULAR REDUCTIVE COUPLING REACTIONS
    GARY MOLANDER; Fiscal Year: 1999
    ..The SmI2-promoted alpha-alkylation reaction of amines and ethers will be applied in cyclization reactions to generate nitrogen heterocycles and bicyclic ethers...
  58. Children's Exposure to Flame Retardants: Effects on Thyroid Hormone Regulation
    HEATHER STAPLETON; Fiscal Year: 2009
    ..The flame retardant chemicals polybrominated diphenyl ethers (PBDEs) are persistent and ubiquitous pollutants, particularly in indoor environments...
  59. NEW STRATEGIES FOR GLYCOCONJUGATE SYNTHESIS FROM ALKYNES
    Frank McDonald; Fiscal Year: 1999
    ..work with molybdenum pentacarbonyl- mediated cycloisomerization reactions of alkynyl alcohols to endocyclic enol ethers (glycals) and specific application of this chemistry to anti- AIDS nucleosides such as dideoxynucleosides, the ..
  60. Sources and Sins of Halogenated Organic Compounds in the Marine Environment
    Paul R Jensen; Fiscal Year: 2012
    There is overwhelming evidence that polybrominated diphenyl-ethers (PBDEs) and polybrominate pyrroles (PBPs) are bioaccumulating in the marine food chain and that these compounds are of biological origin...
  61. ION PAIR CARBON ACIDITY
    Andrew Streitwieser; Fiscal Year: 1990
    ..regio- and stereochemistry in synthesis of biologically active compounds and natural products, such as oxime ethers and dimethylhydrazone derivatives of carbonyl compounds...
  62. Novel Reagents and Devices for the Rapid Detection of Fire Retardant Chemicals.
    ALAN AI PING contact WEI; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Polybrominated diphenyl ethers (PBDEs) are common flame retardants used to reduce the risk of fire in a wide variety of products, such as ..
  63. Advanced Reproductive Age and Environmental Health
    Stephanie Engel; Fiscal Year: 2007
    ..Common endocrine altering (EA) environmental contaminants, including bisphenol A (BPA) and polybrominated diphenyl ethers (PBDEs), are possible human neurotoxins, immune modulators, reproductive toxicants, or may otherwise interfere ..