Distribution of polybrominated diphenyl ethers in human umbilical cord serum, paternal serum, maternal serum, placentas, and breast milk from Madrid population, SpainB Gómara
Department of Instrumental Analysis and Environmental Chemistry, Institute of General Organic Chemistry, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain
Environ Sci Technol 41:6961-8. 2007
..The presence of PBDEs in cord blood and placenta samples indicates that there is prenatal exposure of PBDEs, which could continue after birth via breast milk...
- Levels and distribution of polybrominated diphenyl ethers in water, surface sediments, and bivalves from the San Francisco Estuary
Daniel R Oros
San Francisco Estuary Institute, Oakland, California 94621, USA
Environ Sci Technol 39:33-41. 2005
Polybrominated diphenyl ethers (PBDEs) were found in water, surface sediments, and bivalve samples that were collected from the San Francisco Estuary in 2002...
- Dietary accumulation and metabolism of polybrominated diphenyl ethers by juvenile carp (Cyprinus carpio)
Heather M Stapleton
Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, Solomons, Maryland 20688, USA
Environ Toxicol Chem 23:1939-46. 2004
Polybrominated diphenyl ethers (PBDEs) are hydrophobic organic contaminants with properties and nomenclature similar to polychlorinated biphenyls (PCBs)...
- Polybrominated diphenyl ethers in house dust in Singapore
Jing Tan
Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117576, Singapore
Chemosphere 66:985-92. 2007
The use of polybrominated diphenyl ethers (PBDEs) as flame retardants in Singapore is not strictly regulated; therefore these compounds can be readily found in furniture, electronic devices, and building materials...
- Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea
Novriyandi Hanif
Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903 0213, Japan
J Nat Prod 70:432-5. 2007
Four new (1-4) and 10 known polybrominated diphenyl ethers (5-14) have been isolated from the title sponge. The structures of the new entities were elucidated by interpretation of spectroscopic data and chemical transformations...
- Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers
Ozden Ozel Güven
Department of Chemistry, Zonguldak Karaelmas University, 67100 Zonguldak, Turkey
Bioorg Med Chem Lett 17:2233-6. 2007
In this study, a series of novel phenyl- and benzimidazole-substituted benzyl ethers were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Methicillin-resistant S...
Hydroxylated metabolites of polybrominated diphenyl ethers in human blood samples from the United StatesXinghua Qiu
School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana, USA
Environ Health Perspect 117:93-8. 2009
A previous study from our laboratory showed that polybrominated diphenyl ethers (PBDEs) were metabolized to hydroxylated PBDEs (HO-PBDEs) in mice and that para-HO-PBDEs were the most abundant and, potentially, the most toxic metabolites.
- Isolation and characterization of polybrominated diphenyl ethers as inhibitors of microtubule assembly from the marine sponge Phyllospongia dendyi collected at Palau
Hongwei Liu
Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan
J Nat Prod 67:472-4. 2004
Two new polybrominated diphenyl ethers (1 and 2) were isolated by bioassay-guided separations together with nine known compounds (3-11) from the marine sponge Phyllospongia dendyi collected from Palau...
- Serum concentrations of polybrominated diphenyl ethers (PBDEs) and polybrominated biphenyl (PBB) in the United States population: 2003-2004
Andreas Sjodin
Centers for Disease Control and Prevention, National Center for Environmental Health, 4770 Buford Highway NE, Atlanta, Georgia 30341, USA
Environ Sci Technol 42:1377-84. 2008
Polybrominated diphenyl ethers (PBDEs) and 2,2',4,4',5,5'-hexabromobiphenyl (BB-153) are chemicals known as brominated flame retardants...
Assessing the toxic effects of ethylene glycol ethers using Quantitative Structure Toxicity Relationship modelsPatricia Ruiz
Computational Toxicology Methods Development Laboratory, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30333, USA
Toxicol Appl Pharmacol 254:198-205. 2011
..The use of glycol ethers and their health effects have recently attracted the attention of international organizations such as the World ..
- Formation of alkenes via degradation of tert-alkyl ethers and alcohols by Aquincola tertiaricarbonis L108 and Methylibium spp
Franziska Schäfer
Department of Environmental Microbiology, Helmholtz Centre for Environmental Research UFZ, Permoserstr 15, 04318 Leipzig, Germany
Appl Environ Microbiol 77:5981-7. 2011
..The possible use of alkene formation as an easy-to-measure indicator of aerobic fuel oxygenate biodegradation in contaminated aquifers is discussed...
- Four new aromatic allenic ethers from the fungus Xylaria sp. No. 2508
San Yong Wang
School of Chemistry and Chemical Engineering, Zhongshan University, Guangzhou, China
Nat Prod Res 22:612-7. 2008
Four new aromatic allenic ethers, (7E)-3-(4-buta-2,3-dienyloxy-3-methoxy-phenyl)-acrylic acid methyl ester (1), (7E)-3-[4-(4-buta-2,3-dienyloxy-benzyloxy)-phenyl]-acrylic acid methyl ester (2), 4-(4-buta-2,3-dienyloxy-benzyloxy)-benzoic ..
- An overview of policies for managing polybrominated diphenyl ethers (PBDEs) in the Great Lakes basin
Jessica Ward
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
Environ Int 34:1148-56. 2008
..Polybrominated diphenyl ethers (PBDEs), a class of brominated flame retardant, are among such chemicals, whose concentration in the Great Lakes ..
- Polybrominated diphenyl ethers, polychlorinated biphenyls and organochlorine pesticides in sediment cores from the Western Scheldt river (Belgium): analytical aspects and depth profiles
A Covaci
Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
Environ Int 31:367-75. 2005
..PCBs) and selected organochlorinated pesticides (OCPs) and organobromines, such as polybrominated diphenyl ethers (PBDEs), in sediment samples was optimised using CRM 536 (PCBs in freshwater sediment)...
- Synthesis of analogues of Eunicea gamma-cembranolides containing cyclic ethers via saponification
A D Rodriguez
Department of Chemistry, University of Puerto Rico, P O Box 23346, U P R Station, San Juan, Puerto Rico 00931 3346
J Org Chem 66:648-58. 2001
..While it was shown that a variety of structural modifications are possible, these transformations led typically to nontoxic synthetic cembranoids...
- Synthesis of new 2-naphthyl ethers and their protective activities against DNA damage induced by bleomycin-iron
Bakr F Abdel-Wahab
Applied Organic Chemistry Department, National Research Center, Dokki, Giza, Egypt
Chem Pharm Bull (Tokyo) 57:1348-51. 2009
..Compound 2 showed the greatest protection against DNA damage, thus diminishing chromogen formation between the damaged DNA and thiobarbituric acid...
- Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists
David L Gray
Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, United States
Bioorg Med Chem Lett 19:6604-7. 2009
..Several iterations of design, synthesis, and testing led to substituted piperidine diphenyl ethers which are potent NRIs with 5-HT1(A) partial agonist properties...
- Effects of hexabromocyclododecane and polybrominated diphenyl ethers on mRNA expression in chicken (Gallus domesticus) hepatocytes
Doug Crump
Environment Canada, National Wildlife Research Centre, 1125 Colonel By Drive, Ottawa, Ontario, Canada
Toxicol Sci 106:479-87. 2008
Hexabromocyclododecane (HBCD) and polybrominated diphenyl ethers (PBDEs) are additive flame retardants used in a wide range of consumer products...
- Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers
N J Lawrence
Department of Chemistry, UMIST, Manchester, UK
Bioorg Med Chem Lett 11:51-4. 2001
A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity...
- Children show highest levels of polybrominated diphenyl ethers in a California family of four: a case study
Douglas Fischer
Oakland Tribune, Oakland, California 94612, USA
Environ Health Perspect 114:1581-4. 2006
Polybrominated diphenyl ethers (PBDEs), a major class of flame retardants, are ubiquitous environmental contaminants with particularly high concentrations in humans from the United States...
- Ketone super silyl enol ethers in sequential reactions: diastereoselective generation of tertiary carbinols in one pot
Matthew B Boxer
Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA
J Am Chem Soc 130:1580-2. 2008
- Neonatal exposure to higher brominated diphenyl ethers, hepta-, octa-, or nonabromodiphenyl ether, impairs spontaneous behavior and learning and memory functions of adult mice
Henrik Viberg
Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S-752 36 Uppsala, Sweden
Toxicol Sci 92:211-8. 2006
Polybrominated diphenyl ethers (PBDEs), used as flame retardants, have been shown to be increasing in the environment and in human mother's milk...
- Polybrominated diphenyl ethers (PBDEs) in U.S. mothers' milk
Arnold Schecter
University of Texas Health Sciences Center, School of Public Health, Dallas Regional Campus, Dallas, Texas 75390, USA
Environ Health Perspect 111:1723-9. 2003
..S. population. Other routes of intake may also be significant...
- Global assessment of polybrominated diphenyl ethers in farmed and wild salmon
Ronald A Hites
School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana 47405, USA
Environ Sci Technol 38:4945-9. 2004
..In this paper, we extend these results to polybrominated diphenyl ethers (PBDEs) and show that farm-raised salmon have higher levels of these compounds than wild salmon...
- Polybrominated diphenyl ethers (PBDEs) and their methoxylated derivatives in pike from Swedish waters with emphasis on temporal trends, 1967-2000
A Kierkegaard
Laboratory for Analytical Environmental Chemistry, Institute of Applied Environmental Research, Stockholm University, SE 106 91 Stockholm, Sweden
Environ Pollut 130:187-98. 2004
Temporal trends of five tetra- to hexabromodiphenyl ethers [BDE47, BDE99, BDE100, BDE153 and BDE154) and two methoxy-tetraBDEs [6-methoxy-2,2',4,4'- tetraBDE (6-MeO-BDE47) and 2'-methoxy-2,3',4,5'- tetraBDE (2'-MeO-BDE68)] in pike from ..
- Epoxide-opening cascades promoted by water
Ivan Vilotijevic
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 317:1189-92. 2007
..This strategy offers a high-yielding route to the naturally occurring ladder core and highlights the likely importance of aqueous-medium effects in underpinning certain noteworthy enzymatic selectivities...
- Polybrominated diphenyl ethers in breast milk from Uppsala County, Sweden
Ylva Lind
Swedish National Food Administration, PO Box 622, SE-751 26 Uppsala, Sweden
Environ Res 93:186-94. 2003
The breast milk concentrations of polybrominated diphenyl ethers (PBDEs; sum of five congeners: BDE-47, -99, -100, -153, and -154) were determined (by GC-ECD) in samples from 93 primiparous women collected from 1996 to 1999 in Uppsala ..
- Atmospheric transport of polybrominated diphenyl ethers and polychlorinated biphenyls to the Baltic Sea
Arnout F H ter Schure
Chemical Ecology and Ecotoxicology, Department of Ecology, Lund University, Ecology Building, S 223 62 Lund, Sweden
Environ Sci Technol 38:1282-7. 2004
The atmospheric transport of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) was compared by measuring concentrations in air and deposition on an island located in the central basin of the Baltic Sea...
- Spatial distribution of polybrominated diphenyl ethers in southern Ontario as measured in indoor and outdoor window organic films
Craig M Butt
Department of Geography, University of Toronto, Toronto, Ontario, Canada M5S 3G3
Environ Sci Technol 38:724-31. 2004
..Mean calculated air concentrations were 4.8 pg/m3 for outdoor and 42.1 pg/m3 for indoor urban sites, indicating that urban indoor air is a source of PBDEs to urban outdoor air and the outdoor regional environment...
- Polybrominated diphenyl ethers in the sediments of the Great Lakes. 4. Influencing factors, trends, and implications
An Li
School of Public Health, Department of Civil and Materials Engineering, University of Illinois at Chicago, USA
Environ Sci Technol 40:7528-34. 2006
..16 locations in the five Laurentian Great Lakes, and each was analyzed for 10 congeners of polybrominated diphenyl ethers (PBDEs) as well as selected polychlorinated biphenyls (PCBs)...
- Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations
Ronald A Hites
School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana 47405, USA
Environ Sci Technol 38:945-56. 2004
Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in many types of consumer products...
- Temporal trend studies on tetra- and pentabrominated diphenyl ethers and hexabromocyclododecane in guillemot egg from the Baltic Sea
Ulla Sellström
Laboratory for Analytical Environmental Chemistry, Institute of Applied Environmental Research, Stockholm University, SE 106 91 Stockholm, Sweden
Environ Sci Technol 37:5496-501. 2003
Guillemot eggs from the Baltic Sea, sampled between 1969 and 2001, were analyzed for tetra- and pentabromodiphenyl ethers (2,2',4,4'-tetraBDE (BDE-47), 2,2',4,4',5-pentaBDE (BDE-99), and 2,2',4,4',6-pentaBDE (BDE-100)), and ..
- Brevenal is a natural inhibitor of brevetoxin action in sodium channel receptor binding assays
Andrea J Bourdelais
Center for Marine Science, University of North Carolina at Wilmington, Wilmington, North Carolina 28409, USA
Cell Mol Neurobiol 24:553-63. 2004
..5. Brevenal may serve as a model compound for the development of therapeutics to prevent or reverse intoxication in red tide exposures...
- Different levels of polybrominated diphenyl ethers (PBDEs) and chlorinated compounds in breast milk from two U.K. Regions
Olga I Kalantzi
Department of Environmental Science, Institute of Environmental and Natural Sciences, Lancaster University, Lancaster, United Kingdom
Environ Health Perspect 112:1085-91. 2004
..Key words: breast milk, flame retardants, gas chromatography-mass spectrometry, milk-fat extracts, organochlorines, PBDE-47, persistent contaminants, polybrominated diphenyl ethers, polychlorinated biphenyls, United Kingdom.
- Polybrominated diphenyl ethers and polychlorinated biphenyls in human adipose tissue from New York
Boris Johnson-Restrepo
Wadsworth Center, New York State Department of Health and Department of Environmental Health Sciences, State University of New York at Albany, Empire State Plaza, P.O. Box 509, Albany, New York 12201-0509, USA
Environ Sci Technol 39:5177-82. 2005
..n=52) collected in New York City during 2003-2004 were analyzed for the presence of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs)...
- Is house dust the missing exposure pathway for PBDEs? An analysis of the urban fate and human exposure to PBDEs
Heather A Jones-Otazo
Department of Geography, Centre for Urban Health Initiatives, University of Toronto, 100 St George Street, Toronto, Ontario, Canada
Environ Sci Technol 39:5121-30. 2005
..Ingestion of dust can lead to almost 100-fold higher exposure than "average" for a toddler with a high dust intake rate living in a home in which PBDE concentrations are elevated...
- Microbial reductive debromination of polybrominated diphenyl ethers (PBDEs)
Jianzhong He
Department of Civil and Environmental Engineering, University of California at Berkeley, Berkeley, California 94720-1710, USA
Environ Sci Technol 40:4429-34. 2006
Polybrominated diphenyl ethers (PBDEs) are a class of widely used flame retardants that have recently been detected in environmental samples, diverse biota, human blood serum, and breast milk at exponentially increasing concentrations...
- Cleaning products and air fresheners: emissions and resulting concentrations of glycol ethers and terpenoids
B C Singer
Atmospheric Sciences Department, Environmental Energy Technologies Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Indoor Air 16:179-91. 2006
Experiments were conducted to quantify emissions and concentrations of glycol ethers and terpenoids from cleaning product and air freshener use in a 50-m3 room ventilated at approximately 0.5/h...
- Polybrominated diphenyl ether flame retardants in the U.S. population: current levels, temporal trends, and comparison with dioxins, dibenzofurans, and polychlorinated biphenyls
Arnold Schecter
University of Texas School of Public Health, Dallas Campus, 6011 Harry Hines Boulevard V8 112, Dallas, TX 75390, USA
J Occup Environ Med 47:199-211. 2005
....
- Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation
Steven M Johnson
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA
J Med Chem 48:1576-87. 2005
..Of the library's 95 compounds, 31 were active inhibitors of TTR amyloid formation in vitro. The bisaryloxime ethers selectively stabilize the native tetrameric state of TTR over the dissociative transition state under ..
- Polybrominated diphenyl ethers (PBDEs) in freshwater mussels and fish from Flanders, Belgium
Adrian Covaci
Toxicological Center, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
J Environ Monit 7:132-6. 2005
..50) and most were statistically not significant (p > 0.05). This suggests that the exposure to contaminants arises from local sources possessing different signatures of PBDEs and organochlorine pollutants...
- Gas-phase reactions of brominated diphenyl ethers with OH radicals
Jonathan D Raff
School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana 47405, USA
J Phys Chem A 110:10783-92. 2006
..kinetics and mechanism of the reaction of OH radicals with diphenyl ether and seven polybrominated diphenyl ethers (PBDEs) with 1-2 bromines...
- Recent advances in structural research on ether lipids from archaea including comparative and physiological aspects
Yosuke Koga
Department of Chemistry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
Biosci Biotechnol Biochem 69:2019-34. 2005
..In the last part of this review we discuss this problem...
- Total synthesis and complete assignment of the stereostructure of a cytotoxic bromotriterpene polyether (+)-aurilol
Yoshiki Morimoto
Department of Chemistry, Graduate School of Science, Osaka City University, Sumiyoshi ku, Osaka 558 8585, Japan
J Am Chem Soc 127:5806-7. 2005
....
- Levels of polybrominated diphenyl ethers (PBDEs) in breast milk from central Taiwan and their relation to infant birth outcome and maternal menstruation effects
How Ran Chao
Department of Environmental Science and Engineering, National Pingtung University of Science and Technology, Neipu, Pingtung 912, Taiwan
Environ Int 33:239-45. 2007
In utero exposure to polybrominated diphenyl ethers (PBDEs) reduces the number of ovarian follicles in rat females and causes permanent effects on rat males...
- Semiautomated high-throughput extraction and cleanup method for the measurement of polybrominated diphenyl ethers and polybrominated and polychlorinated biphenyls in breast milk
Andreas Sjodin
National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, Centers for Disease Control and Prevention, 4770 Buford Hwy NE Mail Stop F 17, Atlanta, Georgia 30341, USA
Anal Chem 76:4508-14. 2004
A semiautomated extraction and cleanup method has been developed to measure eight polybrominated diphenyl ethers (PBDEs), 2,2',4,4',5,5'-hexabromobiphenyl (BB-153), and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153)...
- Fate of pentabrominated diphenyl ethers in soil: abiotic sorption, plant uptake, and the impact of interspecific plant interactions
Kevin E Mueller
Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221-0006, USA
Environ Sci Technol 40:6662-7. 2006
Polybrominated diphenyl ethers (PBDEs) are potentially harmful and persistent environmental pollutants. Despite evidence that soils are a major sink for PBDEs, little is known regarding their behavior in this medium...
- Identification of hydroxylated polybrominated diphenyl ether metabolites in blood plasma from polybrominated diphenyl ether exposed rats
Tina Malmberg
Department of Environmental Chemistry, Stockholm University, SE 106 91 Stockholm, Sweden
Environ Sci Technol 39:5342-8. 2005
Polybrominated diphenyl ethers (PBDEs) are ubiquitous environmental contaminants due to their use as flame retardants. Similarly to PCBs, the PBDEs are metabolized to hydroxylated metabolites (OH-PBDEs) in mammals...
- SiMe3-based homologation-epoxidation-cyclization strategy for ladder THP synthesis
Timothy P Heffron
Massachusetts Institute of Technology, Department of Chemistry, Cambridge, MA 02139, USA
Org Lett 5:2339-42. 2003
..A tris-THP was synthesized in 18 total operations from commercial materials using this approach. [reaction: see text]..
- Electron transfer initiated heterogenerative cascade cyclizations: polyether synthesis under nonacidic conditions
V Satish Kumar
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
Org Lett 4:2489-92. 2002
..Both oligotetrahydrofuran and tetrahydropyran structures can be prepared by altering substrate topography...
- Reductive debromination of polybrominated diphenyl ethers in anaerobic sediment and a biomimetic system
John A Tokarz
School of Civil Engineering, and Earth and Atmospheric Sciences, Purdue University, 550 Stadium Mall Drive, West Lafayette, Indiana 47907 2051, USA
Environ Sci Technol 42:1157-64. 2008
..Given the very large BDE-209 burden already in sediments globally, it is important to determine whether this transformation is a significant source of lesser-brominated PBDEs to the environment...
- New clerodane diterpenoid and flavonol-3-methyl ethers from Dodonaea viscosa
M Abdel-Mogib
Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
Pharmazie 56:830-1. 2001
..Sapindaceae) afforded beta-sitosterol, stigmasterol, the flavone acacetin-7-methyl ether, the flavonol-3-methyl ethers 4',5,7-trihydroxy-3,6-dimethoxyflavone and penduletin, as well as a new clerodane diterpenoid which was identified ..
- Novel unsaturated sucrose ethers and their application as monomers
Carina C Crucho
REQUIMTE, Departamento de Química FCT, Universidade Nova de Lisboa, Quinta da Torre, 2829 516 Caparica, Portugal
Molecules 13:762-70. 2008
Novel unsaturated ethers were synthesised in good yields starting from sucrose,using a two-step mild and efficient procedure based on the Gassman method, which consists in forming a vinyl group by the elimination of ethanol from mixed ..
- Polybrominated diphenyl ethers in whitefish from Swiss lakes and farmed rainbow trout
Markus Zennegg
Swiss Federal Laboratories for Materials Testing and Research Empa, Laboratory of Organic Chemistry, Uberlandstrasse 129, 8600 Dubendorf, Switzerland
Chemosphere 51:545-53. 2003
A method for trace analysis of polybrominated diphenyl ethers (PBDE) in fish based on gas chromatography/electron ionization high resolution mass spectrometry (GC/EI-HRMS) was developed, and levels of PBDE were determined in whitefish (..
- Brevisamide: an unprecedented monocyclic ether alkaloid from the dinoflagellate Karenia brevis that provides a potential model for ladder-frame initiation
Masayuki Satake
Center for Marine Science, University of North Carolina, Wilmington, 5600 Marvin K Moss Lane, Wilmington, North Carolina 28409, USA
Org Lett 10:3465-8. 2008
..This report describes the structure elucidation of brevisamide based on detailed MS and NMR spectral analysis, and the importance of this new compound in shedding light on the biogenesis of fused polyethers is discussed...
- Synthesis of vanillin ethers from 4-(bromomethyl) coumarins as anti-inflammatory agents
Manjunath Ghate
Post Graduate Department of Studies in Chemistry, Karnatak University, 580003, Dharwad, India
Eur J Med Chem 38:297-302. 2003
4-(Bromomethyl) coumarins 1 have been reacted with vanillins, 2 and 2A to obtain the corresponding ethers 3 and 5. Ethers 3 have been reacted with ethyl cyanoacetate to obtain the unsaturated esters 4...
- Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis
Yoshihiro Shichijo
Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060 0810, Japan
J Am Chem Soc 130:12230-1. 2008
..This is the first example of the enzymatic epoxide-opening reactions leading to a polyether natural product...
- Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology
P O Darnerud
National Food Administration, Toxicology Division, Uppsala, Sweden
Environ Health Perspect 109:49-68. 2001
Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in plastics (concentration, 5--30%) and in textile coatings...
- Congener-specific accumulation and food chain transfer of polybrominated diphenyl ethers in two arctic food chains
Hans Wolkers
Norwegian Polar Institute, N 9296 Tromsø, Norway
Environ Sci Technol 38:1667-74. 2004
Congener-specific accumulation and prey to predator transfer of 22 polybrominated diphenyl ethers (PBDEs) were assessed in polar cod, ringed seal, polar bear, and beluga whale...
- Synthesis of heterocyclic enol ethers and their use as group 2 metabotropic glutamate receptor antagonists
S Kolczewski
Pharma Division, Preclinical CNS Research, F Hoffmann La Roche Ltd, Basel
Bioorg Med Chem Lett 9:2173-6. 1999
Heterocyclic enol ethers of type 1 were studied with respect to the inhibition of 1S,3R-ACPD (10 microM)-stimulated GTP gamma35S binding on rat mGluR2 transfected cell membranes...
- Precursor-directed biosynthesis of stilbene methyl ethers in Escherichia coli
Yohei Katsuyama
Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
Biotechnol J 2:1286-93. 2007
..Furthermore, the OsPMT gene turned out to be useful in production of unnatural stilbene methyl ethers due to its rather relaxed substrate specificity; various carboxylic acids supplemented as precursors, such as p-..
- The biosynthesis of polyketide-derived polycyclic ethers
Andrew R Gallimore
Dept of Biochemistry, 80 Tennis Court Rd, Cambridge, CB2 1GA, UK
Nat Prod Rep 26:266-80. 2009
The biosynthetic pathways to polyketide-derived polycyclic ethers, in bacteria, plants and marine organisms, have, until now, tended to be considered separately...
- Polybrominated diphenyl ethers (PBDEs) in foodstuffs: human exposure through the diet
A Bocio
Laboratory of Toxicology and Environmental Health, School of Medicine, Rovira i Virgili University, 43201 Reus, Spain
J Agric Food Chem 51:3191-5. 2003
Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in a variety of materials, including synthetic polymers and textiles...
- Overview of toxicological aspects of polybrominated diphenyl ethers: a flame-retardant additive in several consumer products
Chris E Talsness
Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Charite Universitatsmedizin Berlin, Garystr 5, 14195 Berlin, Germany
Environ Res 108:158-67. 2008
Polybrominated diphenyl ethers (PBDEs) are ubiquitous environmental contaminants due to their long half-life and widespread use as flame retardants in several consumer products, including plastics...
- Temporal trends, congener patterns, and sources of octa-, nona-, and decabromodiphenyl ethers (PBDE) and hexabromocyclododecanes (HBCD) in Swiss lake sediments
Martin Kohler
Empa, Swiss Federal Laboratories for Materials Testing and Research, Uberlandstrasse 129, 8600 Dubendorf, Switzerland
Environ Sci Technol 42:6378-84. 2008
....
- Chromatographic and ionization properties of polybrominated diphenyl ethers using GC/high-resolution MS with metastable atom bombardment and electron impact ionization
Michael G Ikonomou
Contaminants Science Section, Institute of Ocean Sciences, Fisheries and Oceans Canada, Sidney, British Columbia
Anal Chem 74:5263-72. 2002
..A significantly higher level of predictability was obtained for the MAB-N2 response model than for EI...
- Polybrominated diphenyl ethers in the sediments of the Great Lakes. 1. Lake Superior
Wenlu Song
School of Public Health, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Environ Sci Technol 38:3286-93. 2004
..Soxhlet-extracted and cleaned up by silica gel fractionation, and the concentrations of 10 polybrominated diphenyl ethers (PBDEs) and 19 polychlorinated biphenyls (PCBs) were measured by GC-MS in SIM mode...
- Dispersive liquid-liquid microextraction followed by reversed phase-high performance liquid chromatography for the determination of polybrominated diphenyl ethers at trace levels in landfill leachate and environmental water samples
Yanyan Li
School of Environmental Science and Public Health, Wenzhou Medical College, Wenzhou 325035, China
Anal Chim Acta 615:96-103. 2008
..microextraction (DLLME), has been developed for the extraction and preconcentration of polybrominated diphenyl ethers (PBDEs) in water samples...
- Determination of fuel dialkyl ethers and BTEX in water using headspace solid-phase microextraction and gas chromatography-flame ionization detection
Idoia Arambarri
, , , Apdo. 1072, , Spain
J Chromatogr A 1033:193-203. 2004
..An extraction time of 10 min was enough to extract the ethers and BTEX. The relative standard deviation (R.S.D.) for the procedure varied from 2.6 (benzene) to 8...
- Alcohols and di-tert-butyl dicarbonate: how the nature of the Lewis acid catalyst may address the reaction to the synthesis of tert-butyl ethers
Giuseppe Bartoli
Dipartimento di Chimica Organica A Mangini, Universita di Bologna, Viale Risorgimento 4, I 40136 Bologna, Italy
J Org Chem 71:9580-8. 2006
The reaction between alcohols and Boc2O leads to the formation of tert-butyl ethers and/or Boc-alcohols, depending on the nature of the Lewis acid catalyst. Product distribution is mainly tuned by the anionic part of the salt...
- Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents
Mariangela Biava
Dipartimento di Studi di Chimica e Tecnologie del Farmaco, Universita La Sapienza, Piazzale Aldo Moro, 5, I 00185 Roma, Italy
Bioorg Med Chem 16:8072-81. 2008
..The affinity data have been rationalized through docking simulations...
- Monofluorinated analogues of polybrominated diphenyl ethers as analytical standards: synthesis, NMR, and GC-MS characterization and molecular orbital studies
Gregor Luthe
Institute of Chemistry, Norwegian University of Science and Technology, N 7041 Trondheim, Norway
Environ Sci Technol 40:3023-9. 2006
Polybrominated diphenyl ethers (PBDEs), a group of 209 individual congeners distinguishable by the number and position of bromines, are produced for use as flame retardants in consumer goods...
- An improved chiral auxiliary for the allene ether version of the Nazarov cyclization
Derrick B delos Santos
Department of Chemistry, 2545 The Mall, University of Hawaii, Honolulu, HI 96822, USA
Org Lett 8:2579-82. 2006
..Enantiomeric excesses of products derived from trisubstituted morpholino enamides varied between 85% and 93% ee. [structure: see text]..
- Trisubstituted aziridine ring-opening by phenol derivatives: stereo- and regioselective formation of chiral tertiary alkyl-aryl ethers
Pixu Li
Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA
Org Lett 8:5105-7. 2006
..reaction features very mild reaction conditions and broad functional group compatibility, which provides a good method for the stereoselective formation of tertiary alkyl-aryl ethers in highly functionalized systems. [reaction: see text]
- Synthesis of densely functionalised arenes using [2 + 2 + 2] cycloaddition reactions
Jonathan Clayden
School of Chemistry, The University of Manchester, Oxford Road, Manchester, UK
Org Biomol Chem 5:1028-30. 2007
Rh(I)-catalysed [2 + 2 + 2] cycloaddition allows the synthesis of aryl ethers and diaryl methanes containing a high degree of steric hindrance from relatively simple diyne and alkyne precursors...
- Regiochemical control in the metal-catalyzed transposition of allylic silyl ethers
Eric C Hansen
Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
J Am Chem Soc 128:8142-3. 2006
..This strategy relies on a cis-oriented vinyl boronate, generated from the Alder-ene reaction of homoallylic silyl ethers and alkynyl boronates, to trap out the allylic hydroxyl group...
- Iminium catalysis
Anniina Erkkilä
Laboratory of Organic Chemistry, Department of Chemical Technology, Helsinki University of Technology, P O Box 6100, FI 02015 TKK, Finland
Chem Rev 107:5416-70. 2007
- An improved Cu-based catalyst system for the reactions of alcohols with aryl halides
Ryan A Altman
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Org Chem 73:284-6. 2008
..The relatively mild conditions, short reaction times, and moderately low catalyst loading allow for a wide array of functional groups to be tolerated on both the electrophilic and nucleophilic coupling partners...
- Synthesis of 7alpha-substituted derivatives of 17beta-estradiol
Xiang-Rong Jiang
Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, 29208, USA
Steroids 71:334-42. 2006
....
- A novel palladium-catalyzed hydroalkoxylation of alkenes with a migration of double bond
Jiajing Tan
Hefei National Laboratory for Physical Science at Microscale, Joint Laboratory of Green Synthetic Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei 230026, PR China
Org Biomol Chem 6:1344-8. 2008
A novel palladium-catalyzed addition of alcohols to olefins was developed, in which a migration of double bond was involved. By this new method, a variety of allylic ethers were prepared with moderate to high yields under mild conditions.
- Synthesis and biological studies of novel 2-aminoalkylethers as potential antiarrhythmic agents for the conversion of atrial fibrillation
Bertrand Plouvier
Cardiome Pharma Corporation, 6190 Agronomy Road, 6th Floor, Vancouver, British Columbia V6T 1Z3
J Med Chem 50:2818-41. 2007
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- Diastereodivergent strategies for the synthesis of homochiral aculeatins
Marine Peuchmaur
Departement de Pharmacochimie Moleculaire, UMR 5063 CNRS Université Joseph Fourier, ICMG FR 2607 CNRS, Bâtiment E, bâtiment André Rassat, 470 rue de la Chimie, 38 041 Grenoble cedex 9, France
J Org Chem 72:5374-9. 2007
..The second part of our study is devoted to improving the yield and the diastereoselectivity of the final phenolic oxidation reaction leading to aculeatins...
- Regioselective synthesis of 5-alkylsalicylates, 5-alkyl-2-hydroxy-acetophenones, and 5-alkyl-2-hydroxy-benzophenones by [3 + 3] cyclization of 1,3-bis(silyl enol ethers) with 2-alkyl-1,1,3,3-tetraethoxypropanes
Constantin Mamat
Institut fur Chemie, Universitat Rostock, Albert Einstein Strasse 3a, 18059 Rostock, Germany
J Org Chem 72:6273-5. 2007
..of 5-alkylsalicylates, 5-alkyl-2-hydroxy-acetophenones, and 5-alkyl-2-hydroxy-benzophenones was regioselectively prepared by TiCl4 mediated formal [3 + 3] cyclization of 1,3-bis(silyl enol ethers) with 2-alkyl-1,1,3,3-tetraethoxypropanes.
- A new type of ketolide bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether: synthesis and structure-activity relationships
Takashi Nomura
Discovery Research Laboratories, Shionogi and Co, Ltd, 12 4, Sagisu 5 Chome, Fukushima ku, Osaka 553 0002, Japan
Bioorg Med Chem 14:3697-711. 2006
..pneumoniae...
- Interplay between core and peripheral chirality in polyethers
Alice R E Brewer
Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
Org Lett 9:3487-90. 2007
....
- Competitive stereochemical control operative during conrotatory electrocyclization of helically equilibrating diquinanyl-substituted 1,3,5,7-octatetraenyl bisenolates
Leo A Paquette
Evans Chemical Laboratories, Ohio State University, Columbus, Ohio 43210, USA
J Org Chem 70:8154-61. 2005
..A competing pathway for the elimination of methanol in these highly functionalized intermediates has been observed for the first time...
- Synthesis of functionalized furans via gold(I)-catalyzed Claisen-type rearrangement
Florin M Istrate
Laboratoire de Synthese Organique, UMR 7652 Ecole Polytechnique, Ecole Polytechnique, 91128 Palaiseau, France
J Org Chem 73:730-3. 2008
Gold(I)-catalyzed cyclization of pentenynyl allyl ethers allows the rapid construction of functionalized furans...
- Mild and nonracemizing conditions for Ullmann-type diaryl ether formation between aryl iodides and tyrosine derivatives
Qian Cai
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
J Org Chem 71:5268-73. 2006
..But their reaction yields are moderate. On the basis of these studies, shorter protocols for assembling (S,S)-isodityrosine and K-13 are developed...
- Asymmetric Michael reaction of acetaldehyde catalyzed by diphenylprolinol silyl ether
Yujiro Hayashi
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan
Angew Chem Int Ed Engl 47:4722-4. 2008
- Nickel-catalyzed cycloadditions of unsaturated hydrocarbons, aldehydes, and ketones
Thomas N Tekavec
Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, UT 84112 0850, USA
J Org Chem 73:2641-8. 2008
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- Bu2SnIH-promoted proximal bond cleavage of methylenecyclopropanes and successive radical cyclization and/or Pd-catalyzed coupling reaction
Naoki Hayashi
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan
J Am Chem Soc 130:2912-3. 2008
- Tuning of the prolyl trans/cis-amide rotamer population by use of C-glucosylproline hybrids
Neil W Owens
Department of Chemistry, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
J Org Chem 72:4635-43. 2007
..Overall, our GlcProH demonstrates variation in Kt/c through tuning of the carbohydrate scaffold: a new concept in proline peptidomimetics...
- Scope and mechanism of formal S(N)2' substitution reactions of a monomeric imidozirconium complex with allylic electrophiles
Gojko Lalic
Department of Chemistry, University of California, Berkeley, California 94720, USA
J Am Chem Soc 130:4459-65. 2008
The zirconium imido complex Cp2(THF)Zr=NSi(t-Bu)Me2 (1) reacts with allylic ethers, chlorides, and bromides to give exclusively the products of the SN2' reaction; i.e...
- A general method for the preparation of ethers using water-resistant solid lewis acids
Avelino Corma
, , Avenida de los Naranjos s/n, 46022 Valencia, Spain
Angew Chem Int Ed Engl 46:298-300. 2007
- Palladium nanoclusters supported on propylurea-modified siliceous mesocellular foam for coupling and hydrogenation reactions
Nandanan Erathodiyil
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore
Chemistry 14:3118-25. 2008
..This immobilized catalyst allows for ease of recovery/reuse and minimization of waste generation, which are of great interest in the development of green chemical processes...
- Automation of fluorous solid-phase extraction for parallel synthesis
Wei Zhang
Fluorous Technologies, Inc, University of Pittsburgh Applied Research Center, Pittsburgh, Pennsylvania 15238, USA
J Comb Chem 8:890-6. 2006
..Approximately 90% of the products have > 90% purity after F-SPE...
- Direct, iridium-catalyzed enantioselective and regioselective allylic etherification with aliphatic alcohols
Satoshi Ueno
Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA
Angew Chem Int Ed Engl 47:1928-31. 2008
- Synthetic studies on maitotoxin. 3. Stereoselective synthesis of the BCDE-ring system
Masanori Satoh
Department of Chemistry, Faculty of Science, Tokyo University of Science, Tokyo, Japan
Org Lett 10:1683-5. 2008
..The key reactions involve SmI 2-induced double cyclization of a beta-alkoxyacrylate and a double dihydroxylation for construction of the B- and E-rings...
- Diphenylprolinol silyl ether as a catalyst in an enantioselective, catalytic, formal aza [3+3] cycloaddition reaction for the formation of enantioenriched piperidines
Yujiro Hayashi
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan
Angew Chem Int Ed Engl 47:4012-5. 2008
- Benzyl protection of phenols under neutral conditions: palladium-catalyzed benzylations of phenols
Ryoichi Kuwano
Department of Chemistry, Graduate School of Sciences, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
Org Lett 10:1979-82. 2008
..Alternatively, the nucleophilic substitution of benzyl methyl carbonates with phenols proceeded in the presence of the catalyst, yielding aryl benzyl ethers.
- Regio- and stereoselective synthesis of alkyl allylic ethers via gold(I)-catalyzed intermolecular hydroalkoxylation of allenes with alcohols
Zhibin Zhang
Duke University, French Family Science Center, Durham, North Carolina 27708 0346, USA
Org Lett 10:2079-81. 2008
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