3 hydroxybutyric acid

Summary

Summary: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver and occurs at high levels in the blood and urine in KETOSIS. (From Dorland's, 28th ed)

Top Publications

  1. ncbi Direct-fed microbial supplementation on ruminal digestion, health, and performance of pre- and postpartum dairy cattle
    J E Nocek
    Spruce Haven Farm and Research Center, Union Springs, NY 13160, USA
    J Dairy Sci 89:260-6. 2006
  2. ncbi Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in mice
    Kevork Hagopian
    Department of Medicine, University of Wisconsin Medical School, Madison, WI 53705, USA
    Exp Gerontol 38:253-66. 2003
  3. ncbi Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose
    A E Greene
    Biology Department, Boston College, Chestnut Hill, Massachusetts 02167, USA
    Epilepsia 42:1371-8. 2001
  4. ncbi Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats
    M Suzuki
    Shimizu Research Center, Research and Development Division, Shimizu Pharmaceutical Co, Ltd, Shizuoka, Japan
    Jpn J Pharmacol 87:143-50. 2001
  5. pmc D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease
    Kim Tieu
    Department of Neurology, Columbia University, New York, New York, USA
    J Clin Invest 112:892-901. 2003
  6. ncbi Ketone bodies, potential therapeutic uses
    R L Veech
    Unit on Metabolic Control, LMMB/NIAAA, Rockville, Maryland, USA
    IUBMB Life 51:241-7. 2001
  7. pmc Role of glucose and ketone bodies in the metabolic control of experimental brain cancer
    T N Seyfried
    Biology Department, Boston College, Chestnut Hill, MA 02467, USA
    Br J Cancer 89:1375-82. 2003
  8. ncbi D-beta-hydroxybutyrate is neuroprotective against hypoxia in serum-free hippocampal primary cultures
    R Masuda
    Laboratory of Metabolic Control National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA
    J Neurosci Res 80:501-9. 2005
  9. ncbi D-beta-hydroxybutyrate protects dopaminergic SH-SY5Y cells in a rotenone model of Parkinson's disease
    Keiko Imamura
    Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan
    J Neurosci Res 84:1376-84. 2006
  10. pmc Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation
    M Maalouf
    Neurology Research, NRC 4th Floor, Barrow Neurological Institute and St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Neuroscience 145:256-64. 2007

Detail Information

Publications195 found, 100 shown here

  1. ncbi Direct-fed microbial supplementation on ruminal digestion, health, and performance of pre- and postpartum dairy cattle
    J E Nocek
    Spruce Haven Farm and Research Center, Union Springs, NY 13160, USA
    J Dairy Sci 89:260-6. 2006
    ..Cows consuming DFM, however, experienced a lower, but not depressed, fat percentage compared with nonsupplemented cows...
  2. ncbi Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in mice
    Kevork Hagopian
    Department of Medicine, University of Wisconsin Medical School, Madison, WI 53705, USA
    Exp Gerontol 38:253-66. 2003
    ..Increased ketone body levels indicate increased utilization of non-carbohydrate fuels while decreased fructose-2,6-bisphosphate level suggests its importance in the control of glycolysis in CR...
  3. ncbi Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose
    A E Greene
    Biology Department, Boston College, Chestnut Hill, Massachusetts 02167, USA
    Epilepsia 42:1371-8. 2001
    ..CONCLUSIONS: We propose that CR may reduce seizure susceptibility in EL mice by reducing brain glycolytic energy. Our preclinical findings suggest that CR may be an effective antiseizure dietary therapy for human seizure disorders...
  4. ncbi Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats
    M Suzuki
    Shimizu Research Center, Research and Development Division, Shimizu Pharmaceutical Co, Ltd, Shizuoka, Japan
    Jpn J Pharmacol 87:143-50. 2001
    ..We demonstrated that BHB, unlike glycerin, when used as an energy substrate in ischemic brain, has protective effects on cerebral hypoxia, anoxia and ischemia-induced metabolic change...
  5. pmc D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease
    Kim Tieu
    Department of Neurology, Columbia University, New York, New York, USA
    J Clin Invest 112:892-901. 2003
    ..Because of the safety record of ketone bodies in the treatment of epilepsy and their ability to penetrate the blood-brain barrier, DbetaHB may be a novel neuroprotective therapy for PD...
  6. ncbi Ketone bodies, potential therapeutic uses
    R L Veech
    Unit on Metabolic Control, LMMB/NIAAA, Rockville, Maryland, USA
    IUBMB Life 51:241-7. 2001
    ..This technical strategy will be critical to the characterization of polygenic disorders by enhancing the knowledge gained from gene analysis and from the subsequent steps and modifications of the protein products themselves...
  7. pmc Role of glucose and ketone bodies in the metabolic control of experimental brain cancer
    T N Seyfried
    Biology Department, Boston College, Chestnut Hill, MA 02467, USA
    Br J Cancer 89:1375-82. 2003
    ..Our results in a mouse astrocytoma suggest that malignant brain tumours are potentially manageable with dietary therapies that reduce glucose and elevate ketone bodies...
  8. ncbi D-beta-hydroxybutyrate is neuroprotective against hypoxia in serum-free hippocampal primary cultures
    R Masuda
    Laboratory of Metabolic Control National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA
    J Neurosci Res 80:501-9. 2005
    ..These findings indicate that ketone bodies may be a candidate for widening the therapeutic window before thrombolytic therapy and at the same time decreasing apoptotic damage in the ischemic penumbra...
  9. ncbi D-beta-hydroxybutyrate protects dopaminergic SH-SY5Y cells in a rotenone model of Parkinson's disease
    Keiko Imamura
    Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan
    J Neurosci Res 84:1376-84. 2006
    ..Ketone bodies, the alternative energy source in the mammalian brain, appear to have therapeutic potential in PD...
  10. pmc Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation
    M Maalouf
    Neurology Research, NRC 4th Floor, Barrow Neurological Institute and St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Neuroscience 145:256-64. 2007
    ..This mechanism may, in part, contribute to the neuroprotective activity of ketones by restoring normal bioenergetic function in the face of oxidative stress...
  11. ncbi KTX 0101: a potential metabolic approach to cytoprotection in major surgery and neurological disorders
    Sharon L Smith
    RenaSci Consultancy Ltd, BioCity, Nottingham, NG1 1GF, UK
    CNS Drug Rev 11:113-40. 2005
    ..These issues are being addressed by designing and synthesizing orally bioavailable multimers of betaOHB with improved pharmacokinetics...
  12. ncbi Ketone body metabolism in lean and obese women
    Esther Vice
    Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    Metabolism 54:1542-5. 2005
    ..The decreased oxidation of ketone bodies by muscle is consistent with aberrations in muscle metabolism in the obese individuals that most likely relates to a decrease in mitochondrial numbers...
  13. ncbi Effects of two different feeding strategies during dry-off on metabolism in high-yielding dairy cows
    M O Odensten
    Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, SE 753 23 Uppsala, Sweden
    J Dairy Sci 88:2072-82. 2005
    ..Our results indicate that dry-off markedly affected the metabolism in the blood and in the rumen of the cows, and that the cows offered only straw during the dry-off were most affected...
  14. ncbi Effect of monensin on milk production of Holstein-Friesian dairy cows
    R H Phipps
    Centre for Dairy Research, Department of Agriculture, The University of Reading, Arborfield, UK
    J Dairy Sci 83:2789-94. 2000
    ..Efficiency of milk production was increased by 5% in experiment 1. In experiment 2, lactation 2, monensin decreased beta-hydroxybutyrate and acetoacetate but increased blood glucose concentration...
  15. ncbi Metabolic predictors of displaced abomasum in dairy cattle
    S J LeBlanc
    Department of Population Medicine, University of Guelph, Ontario, N1G 2W1, Canada
    J Dairy Sci 88:159-70. 2005
    ..Serum calcium concentration was not associated with LDA. Strategic use of metabolic tests to monitor transition dairy cows should focus on NEFA in the last week prepartum and BHBA in the first week postpartum...
  16. ncbi Energy balance, metabolic status, and the first postpartum ovarian follicle wave in cows administered propylene glycol
    S T Butler
    Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
    J Dairy Sci 89:2938-51. 2006
    ..The nonovulatory low estradiol cows also had postpartum metabolic hormone and metabolite profiles indicative of more severe negative energy balance...
  17. ncbi Production and blood parameters of Holstein cows treated prepartum with sodium monensin or propylene glycol
    S O Juchem
    Department of Animal Science, Escola Superior de Agricultura Luiz de Queiroz, University of Sao Paulo, Brazil
    J Dairy Sci 87:680-9. 2004
    ..Prepartum administration of M decreased milk protein content, but no effect was observed on protein yield...
  18. ncbi Effects of feeding intensity during the dry period. 2. Metabolic and hormonal responses
    K Holtenius
    Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, SE 750 07 Uppsala, Sweden
    J Dairy Sci 86:883-91. 2003
    ..In early lactation plasma leptin concentration was not related to adiposity as reflected by body condition scoring. It was suggested that lactation as such affected the leptin concentration in plasma...
  19. ncbi Peripartum performance and metabolism of dairy cows in response to prepartum energy and protein intake
    L Doepel
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2P5
    J Dairy Sci 85:2315-34. 2002
    ..Increasing the protein content of the prepartum diet did not appear to confer any advantages to cow productivity...
  20. pmc beta-Hydroxybutyrate fuels synaptic function during development. Histological and physiological evidence in rat hippocampal slices
    Y Izumi
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 101:1121-32. 1998
    ..These results indicate that D-betaHB is not only able to substitute for glucose as an energy substrate but is also able to preserve neuronal integrity and stability, particularly during early development...
  21. ncbi Tissue-specific stable isotope measurements of postprandial lipid metabolism in familial combined hyperlipidaemia
    Kevin Evans
    Department of Clinical Chemistry, Staffordshire General Hospital, Stafford, UK
    Atherosclerosis 197:164-70. 2008
    ..We used stable isotope techniques combined with tissue-specific measurements in adipose tissue and forearm muscle to investigate fatty acid handling by these tissues in the fasting and postprandial states...
  22. ncbi Gender differences in postprandial ketone bodies in normolipidemic subjects and in untreated patients with familial combined hyperlipidemia
    C J M Halkes
    Department of Vascular Medicine, University Medical Center Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 23:1875-80. 2003
    ..Gender differences in postprandial ketone bodies and C3 changes were investigated in normolipidemic patients and patients with untreated FCHL...
  23. doi Ketogenic diets cause opposing changes in synaptic morphology in CA1 hippocampus and dentate gyrus of late-adult rats
    Marta Balietti
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    Rejuvenation Res 11:631-40. 2008
    ..This implies risks but also promising potentialities for their therapeutic use during aging...
  24. ncbi Lipid metabolite profiles and milk production for Holstein and Jersey cows fed rumen-protected choline during the periparturient period
    N A Janovick Guretzky
    Department of Animal Sciences, University of Illinois, Urbana, 61801, USA
    J Dairy Sci 89:188-200. 2006
    ..More research is needed to determine how choline affects prevention or alleviation of fatty liver syndrome and to confirm potential differences between Holstein and Jersey cows...
  25. ncbi Effects of propylene glycol or fat drench on plasma metabolites, liver composition, and production of dairy cows during the periparturient period
    M M Pickett
    Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
    J Dairy Sci 86:2113-21. 2003
    ....
  26. ncbi Real-time assessment of postprandial fat storage in liver and skeletal muscle in health and type 2 diabetes
    B Ravikumar
    School of Clinical Medical Sciences Diabete s Medical School, University of Newcastle, UK
    Am J Physiol Endocrinol Metab 288:E789-97. 2005
    ..009). We conclude that the postprandial uptake of fatty acids by liver and skeletal muscle is increased in type 2 diabetes and may underlie the elevated tissue triglyceride stores and consequent insulin resistance...
  27. pmc [2,4-13 C2 ]-beta-Hydroxybutyrate metabolism in human brain
    Jullie W Pan
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Cereb Blood Flow Metab 22:890-8. 2002
    ..6% of total acetyl coenzyme A oxidation. These results are consistent with minimal accumulation of cerebral ketones with rapid utilization, implying blood-brain barrier control of ketone oxidation in the nonfasted adult human brain...
  28. ncbi Influence of caloric restriction on motor behavior, longevity, and brain lipid composition in Sandhoff disease mice
    Christine A Denny
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    J Neurosci Res 83:1028-38. 2006
    ..We suggest that the CR delays disease progression in SD and possibly in other ganglioside storage diseases through anti-inflammatory mechanisms...
  29. ncbi Feed intake, milk yield, and metabolic parameters prior to left displaced abomasum in dairy cows
    S C L Van Winden
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 7, 3584 CL, Utrecht, The Netherlands
    J Dairy Sci 86:1465-71. 2003
    ..These preclinical changes may play an important role in the pathogenesis of LDA. It is not certain, however, whether there is a causal association between these parameters and LDA...
  30. ncbi Metabolic responses of lactating dairy cows to single and multiple subcutaneous injections of glucagon
    G Bobe
    Nutritional Physiology Group, Department of Animal Science, Iowa State University, Ames 50011 3150, USA
    J Dairy Sci 86:2072-81. 2003
    ..These results document that both single and multiple injections of 5 mg of glucagon over 14 d consistently improve the carbohydrate status of dairy cows and decrease concentrations of plasma NEFA and BHBA...
  31. ncbi Prepartum intake, postpartum induction of ketosis, and periparturient disorders affect the metabolic status of dairy cows
    H M Dann
    Department of Animal Sciences, University of Illinois, Urbana, 61801, USA
    J Dairy Sci 88:3249-64. 2005
    ..Prepartum intake did not affect postpartum metabolic status or milk yield. Periparturient disorders and induction of ketosis negatively affected metabolic status and milk yield during the first 14 DIM...
  32. ncbi Concentrate feeding strategy in lactating dairy cows: metabolic and endocrine changes with emphasis on leptin
    M Reist
    Institute of Animal Science, Group of Animal Breeding, Swiss Federal Institute of Technology, CH 8092 Zurich, Switzerland
    J Dairy Sci 86:1690-706. 2003
    ..Leptin is one among several factors involved in the regulation of energy metabolism and may be important for overall homeostatic and homeorhetic control of metabolism and thus for maintenance of performance...
  33. ncbi Diurnal variation and the effect of feed restriction on plasma and milk metabolites in TMR-fed dairy cows
    N I Nielsen
    Section of Production Diseases and Immunology in Ruminants, Department of Animal Health and Welfare, Danish Institute of Agricultural Sciences, Foulum, PO Box 50, DK 8830 Tjele, Denmark
    J Vet Med A Physiol Pathol Clin Med 50:88-97. 2003
    ..The relatively high increase in BHB during feed restriction suggests that BHB is more advantageous as a milk indicator of metabolic status in dairy cows than citrate and fat...
  34. ncbi Effect of a monensin controlled release capsule on metabolic parameters in transition dairy cows
    T F Duffield
    Department of Population Medicine, University of Guelph, Guelph, Ontario N1G 2W1
    J Dairy Sci 86:1171-6. 2003
    ..Improvement of energy balance before calving is important for the prevention of energy associated metabolic diseases, such as retained placenta, clinical ketosis, and displaced abomasum, which might occur immediately postcalving...
  35. ncbi Splanchnic metabolism of dairy cows during the transition from late gestation through early lactation
    C K Reynolds
    Centre for Dairy Research, Department of Agriculture, The University of Reading, Earley Gate, Reading RG6 6AT England
    J Dairy Sci 86:1201-17. 2003
    ..Increased net liver removal of propionate (69%), lactate (20%), alanine (8%), and glycerol (4%) can account for increased liver glucose release in transition cows from 9 d before to 11 d after calving...
  36. ncbi Feeding 2-hydroxy-4-(methylthio)-butanoic acid to periparturient dairy cows improves milk production but not hepatic metabolism
    M S Piepenbrink
    Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
    J Dairy Sci 87:1071-84. 2004
    ..3% of metabolizable protein supply is beneficial for increasing milk production but does not appear to benefit hepatic energy metabolism during early lactation...
  37. ncbi Correlation of blood and milk components with the milk yield response to bovine somatotropin in dairy cows
    M T Rose
    School of Agriculture, Food and Rural Development, University of Newcastle upon Tyne NE17RU, United Kingdom
    Domest Anim Endocrinol 28:296-307. 2005
    ..Furthermore, a high MYR to bST was associated with a lower milk plasminogen level before treatment and a greater reduction in the level of plasminogen in milk following treatment...
  38. ncbi Relationship among trans and conjugated fatty acids and bovine milk fat yield due to dietary concentrate and linseed oil
    J J Loor
    Herbivore Research Unit INRA Theix, 63122 St Genes Champanelle, France
    J Dairy Sci 88:726-40. 2005
    ..We observed, however, more drastic milk fat depression when HCO increased yields of total trans-18:1, trans11,cis15-18:2, trans isomers of 18:3, and reduced yields of 18:0 plus cis9-18:1...
  39. ncbi Lactation performance by dairy cows fed supplemental biotin and a B-vitamin blend
    D N Majee
    Department of Dairy Science, University of Wisconsin, Madison 53706, USA
    J Dairy Sci 86:2106-12. 2003
    ..More research is needed to determine the mode of action for supplemental dietary biotin...
  40. ncbi Production and health of pasture-fed dairy cattle following oral treatment with the ionophore lasalocid
    S McDougall
    Animal Health Centre, Morrinsville, New Zealand
    J Dairy Sci 87:2967-76. 2004
    ..Lasalocid treatment of pasture-fed dairy cows resulted in reduced mastitis incidence and increased milk production without changes in body condition or negative effects on metabolic processes as monitored by metabolite concentrations...
  41. ncbi The effect of protein intake on performance of cows in hot environmental temperatures
    A Arieli
    The Hebrew University of Jerusalem, Faculty of Agricultural, Food, and Environmental Quality Sciences, Rehovot, Israel
    J Dairy Sci 87:620-9. 2004
    ..3% is adequate to maintain production in heat-exposed dairy cows producing 35 kg of milk/d, provided that the forced evaporative cooling and the ratio of RDOM to rumen-degradable protein is appropriate..
  42. ncbi Production and metabolic responses of periparturient Holstein cows to dietary conjugated linoleic acid and trans-octadecenoic acids
    K T Selberg
    Department of Animal Sciences, University of Florida, Gainesville 32611, USA
    J Dairy Sci 87:158-68. 2004
    ..Results indicate that dietary CLA and trans-C18:1 fatty acids may affect lipid and glucose metabolism in early postpartum Holstein cows through distinct mechanisms...
  43. ncbi Effects of intravenous triacylglycerol emulsions on hepatic metabolism and blood metabolites in fasted dairy cows
    D G Mashek
    Department of Dairy Science, University of Wisconsin, Madison, 53706, USA
    J Dairy Sci 88:100-9. 2005
    ..Liver TAG content increased 12.0, 7.8, and 14.1 microg/microg of DNA during the fast for tallow, linseed oil, and fish oil treatments, respectively; linseed oil was different from fish oil and tended to be different from tallow...
  44. ncbi Production responses of dairy cows to dietary supplementation with conjugated linoleic acid (CLA) during the transition period and early lactation
    G Bernal-Santos
    Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
    J Dairy Sci 86:3218-28. 2003
    ..These data imply that with CLA treatment in early lactation, dairy cows decreased milk fat synthesis and appeared to respond by partitioning more nutrients toward milk synthesis rather than improving net energy balance...
  45. ncbi Metabolic changes in follicular fluid of the dominant follicle in high-yielding dairy cows early post partum
    J L M R Leroy
    Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Theriogenology 62:1131-43. 2004
    ....
  46. ncbi Feeding glycerol to transition dairy cows: effects on blood metabolites and lactation performance
    J M DeFrain
    Dairy Science Department, South Dakota State University, Brookings 57007, USA
    J Dairy Sci 87:4195-206. 2004
    ....
  47. ncbi Dose-response effects of intrauminal infusion of propionate on feeding behavior of lactating cows in early or midlactation
    M Oba
    Department of Animal Science, Michigan State University, East Lansing 48824 1225, USA
    J Dairy Sci 86:2922-31. 2003
    ..We speculate that lower milk yield for ML compared with EL (30.8 vs. 42.0 kg/d) decreased glucose demand by the mammary gland and increased the proportion of infused propionate oxidized in the liver for ML compared to EL...
  48. ncbi Effects of biotin supplementation on peripartum performance and metabolites of Holstein cows
    O Rosendo
    Department of Animal Sciences, University of Florida, Gainesville 32611, USA
    J Dairy Sci 87:2535-45. 2004
    ..The potential mechanisms that link improved glucose status and decreased lipid mobilization in cows supplemented with biotin warrant further investigation...
  49. ncbi Influence of precalving feed allowance on periparturient metabolic and hormonal responses and milk production in grazing dairy cows
    J R Roche
    Dexcel Ltd, Hamilton, New Zealand
    J Dairy Sci 88:677-89. 2005
    ..These results indicate that the level of feeding in grazing dairy cows during the last month before calving has only small effects on cow metabolic and hormonal status, and on milk production in the first 5 wk of lactation...
  50. ncbi Effect of a monensin controlled-release capsule on rumen and blood metabolites in Florida Holstein transition cows
    P Melendez
    College of Veterinary Medicine, University of Florida, Gainesville, 32610, USA
    J Dairy Sci 87:4182-9. 2004
    ..During the postpartum period, NEFA and BHBA were noticeably lower in treated than in control primiparous cows. This difference was not observed in multiparous cows...
  51. ncbi Energy imbalance related predisposition to mastitis in group-fed high-producing postpartum dairy cows
    Sz Jánosi
    Central Veterinary Institute, Budapest, Hungary
    Acta Vet Hung 51:409-24. 2003
    ..This prognostic value of BHB was significant only in GN + NDP mastitis and in cases caused by GP environmental pathogens, but not in S. aureus mastitis (odds ratio: 5.333, 3.600 and 1.333, respectively)...
  52. ncbi Effects of a single dose of dexamethasone-21-isonicotinate on the metabolism of heifers in early lactation
    R Jorritsma
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Yalelaan 7, Utrecht, The Netherlands
    Vet Rec 155:521-3. 2004
    ..However, there were significant increases in plasma glucose concentrations two days after the injection and in plasma insulin concentrations two and four days after the injection...
  53. ncbi Factors influencing fertility of Holstein dairy cows: a multivariate description
    C T Westwood
    Department of Animal Science, University of Sydney, NSW 2570, Australia
    J Dairy Sci 85:3225-37. 2002
    ..Continued selection for increased production of milk and a more negative nutrient balance during early lactation may reduce reproductive performance particularly for cows fed high concentrations of rumen-degradable protein...
  54. ncbi Effect of milking frequency and diet on milk production, energy balance, and reproduction in dairy cows
    J Patton
    Teagasc Moorepark, Dairy Production Research Centre, Fermoy, Co Cork, Ireland
    J Dairy Sci 89:1478-87. 2006
    ..3d vs. 28.6d; SED = 1.76). In conclusion, once-daily milking in early lactation may promote earlier resumption of ovarian cyclicity, mediated through improved nutritional status...
  55. ncbi Decreased insulin response in dairy cows following a four-day fast to induce hepatic lipidosis
    S Oikawa
    Department of Large Animal Clinical Science, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan 069 8501
    J Dairy Sci 89:2999-3005. 2006
    ..Insulin response was negatively correlated with plasma NEFA and liver triglycerides. Decreased insulin response may be an important complication of negative energy balance and hepatic lipidosis...
  56. ncbi Effect of postruminal glutamine supplementation on immune response and milk production in dairy cows
    L Doepel
    Departement des Sciences Animales, Universite Laval, Ste Foy, Quebec, Canada, G1K 7P4
    J Dairy Sci 89:3107-21. 2006
    ..Over the first 3 wk following calving, Gln supplementation had limited effects on milk production, metabolic parameters, and immune function...
  57. ncbi Effects of weaning and ionophore supplementation on selected blood metabolites and growth in dairy calves
    J L Klotz
    Department of Animal Science, The University of Tennessee, Knoxville, Tennessee 37996, USA
    J Dairy Sci 89:3587-98. 2006
    ..However, supplementation at concentrations currently recommended for control of coccidiosis did not appear to be sufficient to enhance growth or efficiency during the wk 7 to 16 postweaning interval for this sample size...
  58. ncbi Effect of monensin controlled release capsules on blood metabolites in periparturient dairy cows
    E Kennerman
    Uludag University, Faculty of Veterinary Medicine, Department of Internal Medicine, Mudanya Cad, No 2 16190 Merinos Bursa TURKEY
    Aust Vet J 84:282-4. 2006
  59. ncbi Relationships among milk production, energy balance, plasma analytes, and reproduction in Holstein-Friesian cows
    J Patton
    Teagasc Moorepark Dairy Production Research Centre, Fermoy, Co Cork, Ireland
    J Dairy Sci 90:649-58. 2007
    ..Furthermore, results indicate that milk protein content and plasma IGF-I concentration in early lactation may be useful indicators of reproductive efficiency...
  60. ncbi Effects of peripartum propylene glycol or fats differing in fatty acid profiles on feed intake, production, and plasma metabolites in dairy cows
    U Moallem
    Department of Dairy Cattle, Institute of Animal Sciences, Volcani Center, P O Box 6, Bet Dagan, 50250 Israel
    J Dairy Sci 90:3846-56. 2007
    ....
  61. ncbi Relationship between plasma vitamin C and serum diagnostic biochemical markers in lactating cows
    Licza Padilla
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Vet Med Sci 69:909-13. 2007
    ..On the other hand, the high level of glucose possibly decreases plasma vitamin C concentration through suppressing vitamin C recycling...
  62. doi Effect of feeding propionibacteria on milk production by early lactation dairy cows
    W P Weiss
    Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio 44691, USA
    J Dairy Sci 91:646-52. 2008
    ..5 vs. 23.5 kg/d), which resulted in a 4.4% increase in energetic efficiency...
  63. doi The effect of feeding propylene glycol to dairy cows during the early postpartum period on follicular dynamics and on metabolic parameters related to fertility
    D Rizos
    School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
    Theriogenology 69:688-99. 2008
    ..However, we did not observe an effect of PG treatment on follicular dynamics or the length of the postpartum interval. An effect on oocyte developmental competence remains to be proven...
  64. doi Late gestational nutrient restriction: effects on ewes' metabolic and homeorhetic adaptation, consequences for lamb birth weight and lactation performance
    Malin Plumhoff Tygesen
    Department of Animal and Veterinary Basic Sciences, The Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
    Arch Anim Nutr 62:44-59. 2008
    ..It is concluded that severely reduced nutrient availability in late gestation affects fetal growth in utero and has a prolonged negative effect on lactation performance...
  65. doi Production and health of cows given monensin prepartum and a high-energy diet postpartum
    A Arieli
    The Hebrew University of Jerusalem, Faculty of Agricultural, Food and Environmental Quality Sciences, Rehovot 76100, Israel
    J Dairy Sci 91:1845-51. 2008
    ..Our results showed that monensin administration, as a controlled-release capsule in prepartum cows, can be beneficial, even if these cows are maintained on a high-energy diet during the subsequent lactation...
  66. doi Metabolism of dairy cows as affected by prepartum dietary carbohydrate source and supplementation with chromium throughout the periparturient period
    K L Smith
    Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
    J Dairy Sci 91:2011-20. 2008
    ..Insulin addition in vitro did not affect hepatic metabolism of propionate on d 1 postpartum. Overall, both the NFC content of the prepartum diet and Cr-Met had only modest effects on metabolic indices in this experiment...
  67. pmc Metabolic profiles in five high-producing Swedish dairy herds with a history of abomasal displacement and ketosis
    Lena Stengärde
    Division of Ruminant Medicine and Epidemiology, Department of Clinical Sciences, Swedish University of Agricultural Sciences, PO Box 7054, SE 75007, Uppsala, Sweden
    Acta Vet Scand 50:31. 2008
    ....
  68. ncbi Effects of short-term glucagon administration on gluconeogenic enzymes in the liver of midlactation dairy cows
    E L Williams
    Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
    J Dairy Sci 89:693-703. 2006
    ..The data indicate that 24-h administration of glucagon does not alter cytosolic PEPCK mRNA expression or result in immediate alterations in total PEPCK enzyme activity and gluconeogenic capacity...
  69. ncbi Partial feed restriction decreases growth hormone receptor 1A mRNA expression in postpartum dairy cows
    R P Radcliff
    Division of Animal Sciences, University of Missouri, Columbia 65211, USA
    J Dairy Sci 89:611-9. 2006
    ..We concluded that DMI partially controls GHR 1A mRNA expression in early postpartum dairy cows and that the decrease in GHR 1A in response to feed restriction persisted for at least 1 wk after ad libitum feeding was restored...
  70. ncbi Estimation of energy balance at the individual and herd level using blood and milk traits in high-yielding dairy cows
    M Reist
    Institute of Animal Science, Group of Animal Breeding, Swiss Federal Institute of Technology, CH 8092 Zurich, Switzerland
    J Dairy Sci 85:3314-27. 2002
    ..Using blood in addition to milk traits does not improve precision of estimation of herd-level EB, regardless of sample size...
  71. ncbi Performance of dairy cows on Swiss farms with organic and integrated production
    M Roesch
    Division of Nutrition and Physiology, Institute of Animal Genetics, Nutrition and Housing, University of Bern, Bremgartenstrasse 109a, CH 3012 Bern, Switzerland
    J Dairy Sci 88:2462-75. 2005
    ..Lower milk yields were due to a range of individual animal and farm-level factors such as breed, nutrition, management, and udder health...
  72. ncbi To what extent do variabilities in hormones, metabolites and energy intake explain variability in milk yield?
    Klaus Lønne Ingvartsen
    Danish Institute of Agricultural Sciences, Department of Animal Health, Welfare and Nutrition, Research Centre Foulum, P O Box 50, DK 8830 Tjele, Denmark
    Domest Anim Endocrinol 29:294-304. 2005
    ..Perspectives of the analysis for use in prevention of diseases and reproduction are briefly discussed...
  73. ncbi Body condition scores in dairy cows: associations with metabolic and endocrine changes in healthy dairy cows
    A Busato
    Division of Nutrition and Physiology, Faculty of Veterinary Medicine, University of Berne, Berne, Switzerland
    J Vet Med A Physiol Pathol Clin Med 49:455-60. 2002
    ..p. had greater risks of metabolic problems because of excessive mobilization of body reserves. However, the metabolic status was best in cows with a BCS > 3.25 a.p.. if they did not lose much body condition p.p...
  74. ncbi Effects of slow-release insulin on production, liver triglyceride, and metabolic profiles of Holsteins in early lactation
    A Hayirli
    Department of Dairy Science, University of Wisconsin, Madison 53706 1284, USA
    J Dairy Sci 85:2180-91. 2002
    ..In conclusion, a low dose of SRI (0.14 IU/kg of BW) could be considered for prophylactic use against hepatic lipidosis and ketosis...
  75. ncbi Effect of isoflupredone acetate with or without insulin on energy metabolism, reproduction, milk production, and health in dairy cows in early lactation
    H A Seifi
    Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, PO Box 91775 1793, Mashhad, Iran
    J Dairy Sci 90:4181-91. 2007
    ..There were no treatment effects on test-day milk production, milk fat and protein percentages, or the intervals from calving to first insemination or pregnancy...
  76. ncbi The effects of dry period versus continuous lactation on metabolic status and performance in periparturient cows
    J B Andersen
    Danish Institute of Agricultural Sciences, Research Centre Foulum, Department of Animal Health and Welfare, PO Box 50, DK 8830 Tjele, Denmark
    J Dairy Sci 88:3530-41. 2005
    ..Furthermore, these cows are in less metabolic imbalance in the following early lactation...
  77. ncbi Effects of monensin and stage of lactation on variation of blood metabolites within twenty-four hours in dairy cows
    J C Plaizier
    Department of Animal Science, University of Manitoba, Winnipeg, R3T 2N2, Canada
    J Dairy Sci 88:3595-602. 2005
    ..Urea was higher at wk 6 compared with wk -1. The variation within 24 h of glucose, BHBA, and NEFA were not affected by monensin and stage of lactation. Diurnal variation of urea was affected by stage of lactation, but not by monensin...
  78. ncbi The effect of production level on feed intake, milk yield, and endocrine responses to two fatty acid supplements in lactating cows
    K J Harvatine
    Department of Animal Science, Michigan State University, East Lansing 48824, USA
    J Dairy Sci 88:4018-27. 2005
    ..Decreased milk protein synthesis by fat supplementation may be related to FA saturation and milk yield of cows...
  79. ncbi Effects of pre- and postfresh transition diets varying in dietary energy density on metabolic status of periparturient dairy cows
    E Rabelo
    Department of Dairy Science, University of Wisconsin, Madison, 53706, USA
    J Dairy Sci 88:4375-83. 2005
    ..A more favorable metabolic profile occurs when increasing the concentrate content of the diet immediately postpartum compared with delaying the increase until d 21 postpartum...
  80. ncbi Effects of dietary alpha-amylase on metabolism and performance of transition dairy cows
    J M DeFrain
    Dairy Science Department, South Dakota State University, Brookings, 57007, USA
    J Dairy Sci 88:4405-13. 2005
    ....
  81. ncbi Feeding lactose to increase ruminal butyrate and the metabolic status of transition dairy cows
    J M DeFrain
    Dairy Science Department, South Dakota State University, Brookings, 57007, USA
    J Dairy Sci 89:267-76. 2006
    ..Feeding lactose to transition dairy cows increased the proportion of butyrate in the rumen and beta-hydroxybutyrate in plasma and decreased liver lipid but did not affect lactation performance...
  82. ncbi Effects of a four-day hyperinsulinemic-euglycemic clamp in early and mid-lactation dairy cows on plasma concentrations of metabolites, hormones, and binding proteins
    D G Mashek
    Danish Institute of Agricultural Sciences, Department of Animal Health and Welfare, Research Centre Foulum, P.O. Box 50, DK-8830 Tjele, Denmark
    Domest Anim Endocrinol 21:169-85. 2001
    ..Overall, most plasma variables measured were affected in the same way during the two clamps, but the pattern of change often varied with stage of lactation...
  83. ncbi Acute experimental mastitis is not causal toward the development of energy-related metabolic disorders in early postpartum dairy cows
    M R Waldron
    Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
    J Dairy Sci 89:596-610. 2006
    ....
  84. doi Variation in hepatic regulation of metabolism during the dry period and in early lactation in dairy cows
    H A van Dorland
    Veterinary Physiology, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland
    J Dairy Sci 92:1924-40. 2009
    ..In conclusion, metabolic regulation in dairy cows is a dynamic system, and differs obviously between cows at different metabolic stages related to parturition...
  85. pmc Identification and molecular characterization of the acetyl coenzyme A synthetase gene (acoE) of Alcaligenes eutrophus
    H Priefert
    Institut für Mikrobiologie Georg August Universität zu Göttingen, Germany
    J Bacteriol 174:6590-9. 1992
    ..An analysis of mutants provided evidence that the expression of the uptake protein for propionate depends on the presence of alternate sigma factor sigma 54...
  86. ncbi Cloning and nucleotide sequences of genes relevant for biosynthesis of poly(3-hydroxybutyric acid) in Chromatium vinosum strain D
    M Liebergesell
    Institut fur Mikrobiologie, Georg August Universitat Gottingen, Federal Republic of Germany
    Eur J Biochem 209:135-50. 1992
    ..Although the amino acid sequence of PHA synthase deduced from phbCCv exhibited only 24.7% overall similarity with the PHA synthase of A. eutrophus, highly conserved regions were identified...
  87. doi Impact of postpartum milking frequency on the immune system and the blood metabolite concentration of dairy cows
    M C Loiselle
    Department of Biology, Faculty of Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada, J1K 2R1
    J Dairy Sci 92:1900-12. 2009
    ..In conclusion, limiting milk production in early lactation had positive effects on metabolite concentration, but larger studies are necessary to establish if this could reduce disease incidence...
  88. ncbi In vitro synthesis of poly(3-hydroxybutyric acid) by using an enzymatic coenzyme A recycling system
    R Jossek
    Institut fur Mikrobiologie, Westfalische Wilhelms Universitat Munster, Germany
    FEMS Microbiol Lett 168:319-24. 1998
    ..In this way the in vitro synthesis of P(3HB) became independent of the consumption of the expensive coenzyme A. By this procedure a handy system is available to produce in vitro PHA on a semipreparative scale...
  89. ncbi Increased response of Vero cells to PHBV matrices treated by plasma
    Carolina Lucchesi
    Department of Histology and Embryology, Institute of Biology, State University of Campinas, Campinas, SP, Brazil
    J Mater Sci Mater Med 19:635-43. 2008
    ..This combination of surface treatment and polymer chemistry is a valuable guide to prepare an appropriate surface for tissue engineering application...
  90. ncbi Elevated levels of beta-hydroxybutyric acid in periparturient cows and in vitro effect on respiratory burst activity of bovine neutrophils
    D Hoeben
    Department of Physiology, Biochemistry and Biometrics, Faculty of Veterinary Medicine, University of Ghent, Merelbeke Belgium
    Vet Immunol Immunopathol 58:165-70. 1997
    ....
  91. ncbi Exploitation of butyrate kinase and phosphotransbutyrylase from Clostridium acetobutylicum for the in vitro biosynthesis of poly(hydroxyalkanoic acid)
    S J Liu
    Institut fur Mikrobiologie, Westfalische Wilhelms Universitat Munster, Germany
    Appl Microbiol Biotechnol 53:545-52. 2000
    ..Synthesis of various polyesters of 3HB and 4HB with this system was also tested, and copolyesters containing 4HB of 1-46 mol % were obtained...
  92. ncbi The glyoxylate bypass of Ralstonia eutropha
    Zheng Xiang Wang
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, Corrensstrasse 3, 48149 Munster, Germany
    FEMS Microbiol Lett 228:63-71. 2003
    ..eutropha HF39DeltaaceB1 accumulated the same amount of this polyester from gluconate as well as from acetate as R. eutropha HF39...
  93. pmc Analyses of a polyhydroxyalkanoic acid granule-associated 16-kilodalton protein and its putative regulator in the pha locus of Paracoccus denitrificans
    A Maehara
    Laboratory of Molecular Biotechnology, Division of Molecular Cell Mechanisms, Department of Biological Mechanisms and Functions, Graduate School of Bio and Agro Sciences, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    J Bacteriol 181:2914-21. 1999
    ..The phaRPd gene had significant similarities to stdC, a possible transcriptional factor of Comamonas testosteroni, as well as to other ORFs of unknown function previously found in other PHA-synthetic bacteria...
  94. ncbi Use of corticosteroids alone or combined with glucose to treat ketosis in dairy cows
    N Y Shpigel
    Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel
    J Am Vet Med Assoc 208:1702-4. 1996
    ..To compare relative efficacy of dexamethasone and flumethasone alone or in combination with rapid IV infusion of glucose for treatment of ketosis in cattle...
  95. ncbi The effects of diet, sulfonylurea, and Repaglinide therapy on clinical and metabolic parameters in type 2 diabetic patients during Ramadan
    Ramazan Sari
    Department of Endocrinology, Division of Endocrinology and Metabolism, School of Medicine, University of Akdeniz, Antalya, Turkey
    Endocr Res 30:169-77. 2004
    ..Diabetes and its treatment can cause problems for the Muslim population. The aim of this study was to evaluate the effect of different therapy models on clinical and metabolic status in type 2 diabetic patients during Ramadan...
  96. ncbi Dietary L-carnitine affects periparturient nutrient metabolism and lactation in multiparous cows
    D B Carlson
    Department of Animal Sciences, University of Illinois, Urbana 61801, USA
    J Dairy Sci 90:3422-41. 2007
    ..By decreasing liver lipid accumulation and stimulating hepatic glucose output, carnitine supplementation might improve glucose status and diminish the risk of developing metabolic disorders during early lactation...
  97. doi Expression and activity of key hepatic gluconeogenesis enzymes in response to increasing intravenous infusions of glucose in dairy cows
    B Al-Trad
    Institute of Physiology and Pathophysiology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria
    J Anim Sci 88:2998-3008. 2010
    ....
  98. ncbi Two phenotypically compensating isocitrate dehydrogenases in Ralstonia eutropha
    Zheng Xiang Wang
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, Corrensstrabetae 3, 48149, Munster, Germany
    FEMS Microbiol Lett 227:9-16. 2003
    ..These data suggested that IDH1 is induced by acetate. The interposon-mutants HF39Deltaicd1 and HF39Deltaicd2 accumulated the same amount of poly(3-hydroxybutyric acid) as the wild-type...
  99. ncbi Adsorption and hydrolysis reactions of poly(hydroxybutyric acid) depolymerases secreted from Ralstonia pickettii T1 and Penicillium funiculosum onto poly[(R)-3-hydroxybutyric acid]
    Keiji Numata
    Department of Innovative and Engineered Materials, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama, Japan
    Biomacromolecules 8:2276-81. 2007
    ..pickettii T1 was hardly detached but the enzyme from P. funiculosum was released easily from the surface of P(3HB) crystals under an aqueous condition...
  100. ncbi In vitro biosynthesis of poly(3-hydroxybutyric acid) by using purified poly(hydroxyalkanoic acid) synthase of Chromatium vinosum
    R Jossek
    Institut für Mikrobiologie der Westfälischen Wilhelms Universität Münster, Germany
    Appl Microbiol Biotechnol 49:258-66. 1998
    ..Scanning electron micrographs from the synthesized granules were obtained. The granules consisted of poly(3HB) that had a molar mass in the range (1-2) x 10(6) g/mol...
  101. doi The influence of biocomposites containing genetically modified flax fibers on gene expression in rat skeletal muscle
    Tomasz Gredes
    Department of Orthodontics, Preventive and Pediatric Dentistry, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    Biomed Tech (Berl) 55:323-9. 2010
    ..Furthermore, composites from transgenic flax plants producing PHB did not differ from composites of non-transgenic flax plants...

Research Grants64

  1. Effects of Dietary Macronutrients on Regulation of Energy Balance
    KIMBERLY KINZIG; Fiscal Year: 2009
    ....
  2. Effects of Dietary Macronutrients on Regulation of Energy Balance
    Kimberly P Kinzig; Fiscal Year: 2010
    ....
  3. Training Grant in Digestive Diseases and Liver Diseases
    Arun Sanyal; Fiscal Year: 2007
    ..The need for research training, the strong record and continued research strengths of this program for the basis for this application for renewal of this T-32 Training Grant. ..
  4. Career Development in Diabetes for Pediatric Endocrinolo
    Lori Laffel; Fiscal Year: 2007
    ..abstract_text> ..
  5. Age-Dependent Ketone Metabolism After Brain Injury
    Mayumi Prins; Fiscal Year: 2007
    ..abstract_text> ..
  6. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil Jain; Fiscal Year: 2007
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
  7. Biliary Microlithiasis in Alcohol Induced Pancreatitis
    Arun Sanyal; Fiscal Year: 2007
    ..The long-term goal is to use data from this R21 proposal to develop a RO1 proposal about a large scale phase III clinical trial of UDCA for alcohol-induced pancreatitis. ..
  8. Optimizing CGM Use and Metabolic Outcomes in Youth with Type 1 Diabetes
    Lori M Laffel; Fiscal Year: 2010
    ..The current application will evaluate the long-term acceptability and durability of CGM, and assess the metabolic outcomes and behavioral impact of CGM on pediatric patients with T1D and their families. ..
  9. Structural and Functional Properties of cyclophilin D and Abeta interaction.
    Shi Du Yan; Fiscal Year: 2010
    ..The results of this proposal will have a profound impact on the AD field by establishing a new target for preventive and therapeutic intervention. ..
  10. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil K Jain; Fiscal Year: 2010
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
  11. Food Cues, Calories and Energy Regulation in Rats
    SUSAN SWITHERS; Fiscal Year: 2009
    ..Given the rapidity with which overweight and obesity continue to increase, identifying such novel approaches is becoming increasingly critical ..
  12. Food Cues, Calories and Energy Regulation in Rats
    Susan E Swithers; Fiscal Year: 2010
    ..Given the rapidity with which overweight and obesity continue to increase, identifying such novel approaches is becoming increasingly critical ..
  13. Nonalcoholic steatohepatitis and Cytochrome P450 Enzymes
    Naga P Chalasani; Fiscal Year: 2010
    ..Additionally, we examine the relationship between this enzyme activity and the degree of insulin resistance and lipid peroxidation. ..
  14. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil Jain; Fiscal Year: 2009
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
  15. Food Cues, Calories and Energy Regulation in Rats
    SUSAN SWITHERS; Fiscal Year: 2009
    ..Given the rapidity with which overweight and obesity continue to increase, identifying such novel approaches is becoming increasingly critical ..
  16. GLYCOSPHINGOLIPIDS IN MURINE NEURODEGENERATIVE DISEASES
    THOMAS SEYFRIED; Fiscal Year: 2009
    ..The proposed studies will provide essential information on combinatorial therapies for the ganglioside storage diseases and will have translational benefit to the clinic. ..
  17. Leptin As A Novel Neurohormonal Anticonvulsant
    KWEE THIO; Fiscal Year: 2007
    ....
  18. Studies of Mechanisms and Treatment of Liver Diseases
    Arun Sanyal; Fiscal Year: 2007
    ..Much progress has been made and supports the hypothesis. The institutional environment and facilities/resources are excellent for career development in academic medicine. ..
  19. Clinical Research on Non-Alcoholic Steatohepatitis
    Naga Chalasani; Fiscal Year: 2007
    ..The secondary end-points are changes in insulin resistance, lipid peroxidation, determinants of oxidative stress, anthropometric measurements, liver biochemistry, and the measures of quality of life. ..
  20. ERAB, A BETA, NEUROTOXICITY AND ALZHEIMERS DISEASE
    Shi Du Yan; Fiscal Year: 2003
    ..abstract_text> ..
  21. ONTOGENY OF METABOLIC CONTROLS OF INGESTIVE BEHAVIOR
    SUSAN SWITHERS; Fiscal Year: 2002
    ..Finally, the neural mechanisms involved in translating physiological changes related to energy utilization into increases in ingestive behavior are tested. ..
  22. OPTIMIZING ADHERENCE AND GLYCEMIA IN YOUTH WITH NEW IDDM
    Lori Laffel; Fiscal Year: 2001
    ....
  23. Fatty Acid Oxidation Disorders & Body Weight Regulation
    MELANIE GILLINGHAM; Fiscal Year: 2007
    ..Results from these studies will enhance our understanding of the role of FAO in body composition and insulin resistance, and may provide a new dietary treatment to prevent obesity in children with long-chain FAO disorders. ..
  24. Nonalcoholic steatohepatitis and Cytochrome P450 Enzymes
    Naga Chalasani; Fiscal Year: 2007
    ..Additionally, we examine the relationship between this enzyme activity and the degree of insulin resistance and lipid peroxidation. ..
  25. Epileptogenicity in the Developing Brain
    Raman Sankar; Fiscal Year: 2007
    ..Our findings will provide the basis for future neuroprotective interventions targeting the developing brain at different stages of status epilepticus in order to interrupt the course of the epileptogenic process. ..
  26. Markers of normoglycemic remission in obese diabetics
    Guillermo Umpierrez; Fiscal Year: 2006
    ..Identifying such markers will facilitate and guide future therapeutic interventions and may identify patients at risk to develop chronic complications of diabetes ..
  27. Mechanisms of Inhibitory Glycine Receptor Modulation
    KWEE THIO; Fiscal Year: 2006
    ..abstract_text> ..
  28. Genes controlling heart function in a hibernating mammal
    Matthew Andrews; Fiscal Year: 2005
    ..abstract_text> ..
  29. Diet Therapy of Long-Chain Fatty Acid Oxidation Defects
    MELANIE GILLINGHAM; Fiscal Year: 2005
    ..abstract_text> ..
  30. Hypoglycemia and the Developing Brain
    SUSAN VANNUCCI; Fiscal Year: 2005
    ....
  31. Training Grant in Diabetes for Pediatric Endocrinologis*
    Lori Laffel; Fiscal Year: 2006
    ..We have demonstrated the ability to attract highly qualified candidates to our training program and look forward to meeting the challenge of training and developing successful pediatric endocrinologists in diabetes research. ..
  32. CLINICAL STUDIES OF NONALCOHOLIC STEATOHEPATITIS
    Arun Sanyal; Fiscal Year: 2007
    ..A prospective, randomized short-term ( 1 year duration) clinical trial to test this hypothesis is proposed. The primary endpoint is the necro-inflammatory grade. Both studies will require participation of the network. ..