fenoprofen

Summary

Summary: An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to ASPIRIN, but causes less gastrointestinal bleeding.

Top Publications

  1. ncbi Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates
    Marijana Zovko
    Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
    Acta Pharm 55:169-76. 2005
  2. ncbi Macromolecular prodrugs: X. Kinetics of fenoprofen release from PHEA-fenoprofen conjugate
    T van der Merwe
    Department of Pharmaceutical Chemistry, Potchefstroom University for CHE, P B X6001, Potchefstroom 2520, South Africa
    Int J Pharm 241:223-30. 2002
  3. ncbi Presystemic and systemic chiral inversion of R-(-)-fenoprofen in the rat
    B W Berry
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada
    J Pharmacol Exp Ther 258:695-701. 1991
  4. ncbi Influence of rheumatoid arthritis in the enantioselective disposition of fenoprofen
    Giuliano Rodrigo Barissa
    Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Avenida do Cafe s n, Campus da USP, 14040 903 Ribeirao Preto, Sao Paulo, Brazil
    Chirality 16:602-8. 2004
  5. ncbi Inhibition kinetics of hepatic microsomal long chain fatty acid-CoA ligase by 2-arylpropionic acid non-steroidal anti-inflammatory drugs
    K M Knights
    Dept of Clinical Pharmacology, Flinders University of South Australia
    Biochem Pharmacol 43:1465-71. 1992
  6. ncbi Stereoselective disposition of fenoprofen in plasma and synovial fluid of patients with rheumatoid arthritis
    Carolina De Miranda Silva
    Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Chirality 19:255-63. 2007
  7. ncbi Pharmacodynamics, chiral pharmacokinetics, and pharmacokinetic-pharmacodynamic modeling of fenoprofen in patients with diabetes mellitus
    Josiane Cristófani Poggi
    Faculdade de Ciências Farmacêuticas de Ribeirão Preto USP, Departamento de Fisica e Quimica, Avenida do Café s n Campus da USP, 14040 903 Ribeirao Preto, Sao Paulo, Brazil
    J Clin Pharmacol 46:1328-36. 2006
  8. ncbi Effect of antimicrobial and anti-inflammatory medications on the sense of taste
    S S Schiffman
    Department of Psychiatry, Box 3259, Duke University Medical School, Durham, NC 27710, USA
    Physiol Behav 69:413-24. 2000
  9. ncbi Distribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower Great Lakes, Canada
    Chris D Metcalfe
    Water Quality Centre, Trent University, Peterborough, Ontario K9J 7B8, Canada
    Environ Toxicol Chem 22:2881-9. 2003
  10. ncbi Evaluation of pharmaceuticals and personal care products as water-soluble molecular markers of sewage
    Norihide Nakada
    Laboratory of Organic Geochemistry LOG, Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183 8509, Japan
    Environ Sci Technol 42:6347-53. 2008

Research Grants

  1. ACYL GLUCURONIDES: COVALENT BINDING & PHARMACOKINETICS
    Leslie Benet; Fiscal Year: 1993
  2. GUSTATORY AND OLFACTORY CHANGES WITH AGE
    SUSAN SCHIFFMAN; Fiscal Year: 2005

Scientific Experts

Detail Information

Publications107 found, 100 shown here

  1. ncbi Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates
    Marijana Zovko
    Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
    Acta Pharm 55:169-76. 2005
    ..Two types of polymer-drug conjugates were synthesized starting from styrene-maleic acid anhydride copolymer (SMA). Fenoprofen and gemfibrozil were chosen as model drugs because of their short plasma half lives...
  2. ncbi Macromolecular prodrugs: X. Kinetics of fenoprofen release from PHEA-fenoprofen conjugate
    T van der Merwe
    Department of Pharmaceutical Chemistry, Potchefstroom University for CHE, P B X6001, Potchefstroom 2520, South Africa
    Int J Pharm 241:223-30. 2002
    The kinetics of fenoprofen release from poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)]-fenoprofen conjugate (PHEA-Fen) in aqueous buffer solutions (pH 10 and 1.1), simulated gastric (SGF) and intestinal fluids (SIF) was studied...
  3. ncbi Presystemic and systemic chiral inversion of R-(-)-fenoprofen in the rat
    B W Berry
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada
    J Pharmacol Exp Ther 258:695-701. 1991
    b>Fenoprofen (FN), a member of the 2-arylpropionic acid (2-APA) class of nonsteroidal anti-inflammatory drugs is administered clinically as a racemate...
  4. ncbi Influence of rheumatoid arthritis in the enantioselective disposition of fenoprofen
    Giuliano Rodrigo Barissa
    Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Avenida do Cafe s n, Campus da USP, 14040 903 Ribeirao Preto, Sao Paulo, Brazil
    Chirality 16:602-8. 2004
    To investigate the influence of rheumatoid arthritis on the stereoselective disposition of fenoprofen administered as a racemic mixture, eight patients with rheumatoid arthritis receiving calcium rac-fenoprofen (200 mg/8 h) and 7 healthy ..
  5. ncbi Inhibition kinetics of hepatic microsomal long chain fatty acid-CoA ligase by 2-arylpropionic acid non-steroidal anti-inflammatory drugs
    K M Knights
    Dept of Clinical Pharmacology, Flinders University of South Australia
    Biochem Pharmacol 43:1465-71. 1992
    ..Inhibition of the high affinity isoform was studied using the R and S enantiomers of ibuprofen, fenoprofen, ketoprofen and naproxen...
  6. ncbi Stereoselective disposition of fenoprofen in plasma and synovial fluid of patients with rheumatoid arthritis
    Carolina De Miranda Silva
    Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Chirality 19:255-63. 2007
    The simultaneous disposition of fenoprofen enantiomers in synovial fluid and plasma was studied in 11 patients with arthritis and chronic knee effusions treated with a single oral dose of 600 mg rac-fenoprofen...
  7. ncbi Pharmacodynamics, chiral pharmacokinetics, and pharmacokinetic-pharmacodynamic modeling of fenoprofen in patients with diabetes mellitus
    Josiane Cristófani Poggi
    Faculdade de Ciências Farmacêuticas de Ribeirão Preto USP, Departamento de Fisica e Quimica, Avenida do Café s n Campus da USP, 14040 903 Ribeirao Preto, Sao Paulo, Brazil
    J Clin Pharmacol 46:1328-36. 2006
    ..of type 1 and type 2 diabetes mellitus on the enantioselective pharmacodynamics and pharmacokinetics of fenoprofen. Patients with diabetes mellitus type 1 (n = 7) or type 2 (n = 7) and healthy volunteers (n = 13) received ..
  8. ncbi Effect of antimicrobial and anti-inflammatory medications on the sense of taste
    S S Schiffman
    Department of Psychiatry, Box 3259, Duke University Medical School, Durham, NC 27710, USA
    Physiol Behav 69:413-24. 2000
    ..The six NSAIDS were: diclofenac sodium salt, fenoprofen calcium salt, ibuprofen, ketoprofen, nabumetone, and sulindac...
  9. ncbi Distribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower Great Lakes, Canada
    Chris D Metcalfe
    Water Quality Centre, Trent University, Peterborough, Ontario K9J 7B8, Canada
    Environ Toxicol Chem 22:2881-9. 2003
    ..However, clofibric acid, ketoprofen, fenoprofen, and carbamazepine were detected in samples collected in the summer of 2000 at sites in Lake Ontario and at a ..
  10. ncbi Evaluation of pharmaceuticals and personal care products as water-soluble molecular markers of sewage
    Norihide Nakada
    Laboratory of Organic Geochemistry LOG, Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183 8509, Japan
    Environ Sci Technol 42:6347-53. 2008
    ..The PPCPs were crotamiton, ibuprofen, naproxen, ketoprofen, fenoprofen, mefenamic acid, thymol, triclosan, propyphenazone, carbamazepine, diethyltoluamide, ethenzamide, and caffeine...
  11. pmc Use of a robust dehydrogenase from an archael hyperthermophile in asymmetric catalysis-dynamic reductive kinetic resolution entry into (S)-profens
    Jacob A Friest
    Department of Chemistry, University of Nebraska, Lincoln, Nebraska 68588, USA
    J Am Chem Soc 132:5930-1. 2010
    ..to the NSAIDs (nonsteroidal anti-inflammatory drugs) naproxen, ibuprofen, flurbiprofen, ketoprofen, and fenoprofen. To our knowledge, this is the first application of a dehydrogenase from this Sulfolobus hyperthermophile to ..
  12. ncbi Removal of selected pharmaceuticals and personal care products (PPCPs) and endocrine-disrupting chemicals (EDCs) during sand filtration and ozonation at a municipal sewage treatment plant
    Norihide Nakada
    Laboratory of Organic Geochemistry, Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183 8509, Japan
    Water Res 41:4373-82. 2007
    ..antiseptics (thymol, triclosan), 5 acidic analgesics or anti-inflammatories (ibuprofen, naproxen, ketoprofen, fenoprofen, mefenamic acid), 4 amide pharmaceuticals (propyphenazone, crotamiton, carbamazepine, diethyltoluamide), 7 ..
  13. ncbi Effects of non-ionic surfactants on isotachophoretic separations of 2-arylpropionic acids
    J Sadecka
    Department of Analytical Chemistry, Faculty of Chemical and Food Technology, Radlinskeho 9, 812 37 Bratislava, Slovakia
    J Chromatogr A 1084:152-9. 2005
    ..Tergitol NPX) modified capillary isotachophoresis was investigated for the separation of 2-arylpropionic acids (fenoprofen, flurbiprofen, ibuprofen, ketoprofen and naproxen) and benzoic acid and its derivatives (salicylic, ..
  14. ncbi Species differences in inhibition potential of nonsteroidal anti-inflammatory drugs against estradiol 3beta-glucuronidation between rats, dogs, and humans
    Yuji Mano
    Drug Metabolism Research Laboratories, Astellas Pharma, Inc, Tokyo, Japan
    J Pharm Sci 97:2805-10. 2008
    ..Among the NSAIDs investigated (diclofenac, diflunisal, fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen, mefenamic acid, niflumic acid, and sulindac), only niflumic ..
  15. doi Ibuprofen-arginine generates nitric oxide and has enhanced anti-inflammatory effects
    Clara De Palma
    Unit of Clinical Pharmacology, Department of Preclinical Sciences, University of Milano, 20157 Milan, Italy
    Pharmacol Res 60:221-8. 2009
    Ibuprofen, a chiral non-steroidal anti-inflammatory drug chemically related to fenoprofen and naproxen, has moderate but definite anti-inflammatory, analgesic and antipyretic properties, with considerably less gastrointestinal adverse ..
  16. ncbi Rapid online-SPE-MS/MS method for ketoprofen determination in dermal interstitial fluid samples from rats obtained by microdialysis or open-flow microperfusion
    Karin E Pickl
    Institute of Medical Technologies and Health Management, Joanneum Research, Auenbruggerplatz 20 3, 8036 Graz, Austria
    J Chromatogr B Analyt Technol Biomed Life Sci 850:432-9. 2007
    ..In addition, a commercial available (fenoprofen) as well as an isotopically labelled (deuterated ketoprofen) standard were investigated as potential internal ..
  17. ncbi Thioesterification of 2-arylpropionic acids by recombinant acyl-coenzyme A synthetases (ACS1 and ACS2)
    C Sevoz
    Unité Associée DGER INRA Toxicologie et Métabolisme Comparés des Xénobiotiques, Ecole Nationale Veterinaire de Lyon, Marcy l Etoile, France
    Drug Metab Dispos 28:398-402. 2000
    ..strains and purified to homogeneity to investigate the involvement of these enzymes in the thioesterification of fenoprofen and ibuprofen...
  18. ncbi Determination of acidic drugs and caffeine in municipal wastewaters and receiving waters by gas chromatography-ion trap tandem mass spectrometry
    Sergei S Verenitch
    University of Victoria, Water and Watershed Research Program, P O Box 3020 STN CSC, Victoria, BC, Canada V8W 3N5
    J Chromatogr A 1116:193-203. 2006
    ..and instrumental techniques for analysis of such acidic drugs as acetylsalicylic acid, ibuprofen, gemfibrozil, fenoprofen, naproxen, ketoprofen, and diclofenac, as well as caffeine in surface water and municipal wastewater have been ..
  19. ncbi Cationic beta-cyclodextrin derivative for chiral separations
    J L Haynes
    Department of Chemistry, Louisiana State University, Baton Rouge 70820, USA
    J Chromatogr A 803:261-71. 1998
    ..beta-CD-OMe (VII)] performs exceptionally well for the enantiomeric resolution of NSAIDs: indoprofen and fenoprofen (Rs = 11 and 14, respectively)...
  20. doi Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+ chelating activity
    Zrinka Rajic
    Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
    Acta Pharm 60:325-37. 2010
    ..two steps: i) preparation of NSAID benzotriazolides 3a-h from the corresponding NSAID (ibuprofen, ketoprofen, fenoprofen, ketoprofen hydroxy and methylene analogues, diclofenac or indomethacin) and benzotriazole carboxylic acid ..
  21. doi Using subcritical/supercritical fluid chromatography to separate acidic, basic, and neutral compounds over an ionic liquid-functionalized stationary phase
    Fu Min Chou
    Department of Chemistry and Biochemistry, National Chung Cheng University, Min Hsiung, Chia Yi 621, Taiwan
    J Chromatogr A 1216:3594-9. 2009
    ..The model compounds tested for SFC separation are acetaminophen, metoprolol, fenoprofen, ibuprofen, naphthalene, and testosterone...
  22. ncbi Enantioseparation by CE with vancomycin as chiral selector: Improving the separation performance by dynamic coating of the capillary with poly(dimethylacrylamide)
    Zhaoyan Wang
    College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China
    Electrophoresis 28:938-43. 2007
    ..Under the optimal conditions, all tested enantiomers, including FMOC amino acids derivatives, ketoprofen and fenoprofen, were baseline-separated in less than 4.2 min.
  23. ncbi Quadrupole time-of-flight versus triple-quadrupole mass spectrometry for the determination of non-steroidal antiinflammatory drugs in surface water by liquid chromatography/tandem mass spectrometry
    Stefano Marchese
    Dipartimento di Chimica, Universita La Sapienza di Roma, Piazzale Aldo Moro n degrees 5, PO Box 34, Posta 62, 00185 Roma, Italy
    Rapid Commun Mass Spectrom 17:879-86. 2003
    ..The drugs investigated were the analgesics Ibuprofen, Fenoprofen, Ketoprofen, Naproxen, and Diclofenac...
  24. doi A protein-coated magnetic beads as a tool for the rapid drug-protein binding study
    Michał Piotr Marszałł
    Department of Biopharmacy, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, M Skłodowskiej Curie 9, 85 094 Bydgoszcz, Poland
    J Pharm Biomed Anal 52:420-4. 2010
    ..The K(a) for l-tryptofan, fenoprofen, ketoprofen, tolbutamide and warfarin obtained from Schathard analysis are consistent with previously reported ..
  25. pmc Combined use of chiral ionic liquid and CD for MEKC: Part II. Determination of binding constants
    Bin Wang
    Department of Chemistry, Center of Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30303, USA
    Electrophoresis 30:2820-8. 2009
    ..The binding constants of one representative profen (e.g. fenoprofen) to TM-beta-CD and L-UCLB were estimated by a secondary plotting approach...
  26. doi Isolation and characterization of enantioselective DNA aptamers for ibuprofen
    Yeon Seok Kim
    School of Life Sciences and Biotechnology, Korea University, Anam Dong, Seongbuk gu, Seoul 136 701, South Korea
    Bioorg Med Chem 18:3467-73. 2010
    ..5-5.2microM. In addition, all of these five aptamers did not show any affinity to analogues of ibuprofen in its profen's group (fenoprofen, flubiprofen, and naproxen) and the antibiotics of oxytetracycline, another control.
  27. ncbi Interaction of ibuprofen and other structurally related NSAIDs with the sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8)
    Shirou Itagaki
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Pharm Res 23:1209-16. 2006
    ..Many nonsteroidal anti-inflammatory drugs (NSAIDs) are monocarboxylates. Therefore, we investigated the interaction of these drugs with human SMCT1 (hSMCT1)...
  28. pmc Sodium-coupled monocarboxylate transporters in normal tissues and in cancer
    Vadivel Ganapathy
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912, USA
    AAPS J 10:193-9. 2008
    ..Non-steroidal anti-inflammatory drugs such as ibuprofen, ketoprofen, and fenoprofen, also interact with SLC5A8...
  29. doi Chiral separation of fluvastatin enantiomers by capillary electrophoresis
    Tran Quoc Trung
    College of Pharmacy, Kangwon National University, Chuncheon 200 701, Korea
    Arch Pharm Res 31:1066-72. 2008
    ..mM-borate solution containing 30 mg/mL of (2-hydroxypropyl)-beta-cyclodextrin (HP-beta-CD) as running buffer and fenoprofen as an internal standard. The linearity was observed within a 400-700 microg/mL concentration range (r(2)>or=0...
  30. doi Electrokinetic supercharging focusing in capillary zone electrophoresis of weakly ionizable analytes in environmental and biological samples
    Igor Botello
    Departament de Quimica Analitica i Quimica Organica, Faculty of Chemistry, Universitat Rovira i Virgili, Marcel li Domingo s n, Tarragona, Spain
    Electrophoresis 31:2964-73. 2010
    Five non-steroidal anti-inflammatory drugs, naproxen, fenoprofen, ketoprofen, diclofenac and piroxicam, were separated and analyzed by electrokinetic supercharging in CZE...
  31. ncbi Determination of acidic pharmaceuticals, antibiotics and ivermectin in river sediment using liquid chromatography-tandem mass spectrometry
    Dirk Löffler
    Bundesanstalt fur Gewasserkunde, P O Box 20 02 53, D 56002 Koblenz, Germany
    J Chromatogr A 1021:133-44. 2003
    ..The acidic compounds clofibric acid, diclofenac, fenoprofen, gemfibrozil, ibuprofen, 2-hydroxy-ibuprofen, indomethacin, ketoprofen, naproxen and the parasiticide ivermectin ..
  32. ncbi Peroxisome-proliferating effects of fenoprofen in mice
    D De Craemer
    Menselijke Anatomie and Embryologie, Vrije Universiteit Brussel, Belgium
    Lipids 33:539-43. 1998
    We report on hepatic effects obtained in vivo by treating mice with different doses of fenoprofen, an arylpropionic acid previously shown to inhibit in vitro peroxisomal very long chain fatty acid oxidation...
  33. ncbi Disposition of human drug preparations in the horse. IV. Orally administered fenoprofen
    F T Delbeke
    Farmacie and Toxicologie, Falculteit Diergeneeskunde, Universiteit Gent, Merelbeke, Belgium
    J Pharm Biomed Anal 13:1041-7. 1995
    Plasma and urinary concentrations of the non-steroidal anti-inflammatory drug fenoprofen were determined by a high-performance liquid chromatographic procedure following oral administration of a dose of 3 g to fed and fasted horses...
  34. ncbi Interaction of valproic acid with nonsteroidal antiinflammatory drugs mefenamic acid and fenoprofen in normal and uremic sera: lack of interaction in uremic sera due to the presence of endogenous factors
    A Dasgupta
    Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, USA
    Ther Drug Monit 18:654-9. 1996
    ..The nonsteroidal antiinflammatory drugs mefenamic acid and fenoprofen are also strongly bound to albumin...
  35. ncbi Optimization of gas chromatographic method for the enantioseparation of arylpropionic non-steroidal anti-inflammatory drug methyl esters
    Marinko Petrović
    PLIVA Research and Development Ltd, Prilaz baruna Filipovica 29, 10 000 Zagreb, Croatia
    J Pharm Biomed Anal 39:531-4. 2005
    ..chromatography (GC) method for enantioseparation of well-known non-steroidal anti-inflammatory drugs ibuprofen, fenoprofen and ketoprofen methyl esters mixture was developed...
  36. ncbi Inhibition of aromatic amino acid decarboxylase by a group of non-steroidal anti-inflammatory drugs
    M Pribová
    Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Hradec Kralove, Czechoslovakia
    Pharmacol Res 25:271-7. 1992
    ..flobufen and 2',4'-difluorobiphenyl-4-yl acetate) and propionic acid derivatives (ibuprofen, ketoprofen, fenoprofen) were one order weaker...
  37. ncbi (-)-R-fenoprofen: formation of fenoprofenyl-coenzyme A by rat liver microsomes
    E Benoit
    Unité associée de Toxicologie Métabolique et d écotoxicologie INRA ENVL, Ecole Nationale Veterinaire de Lyon, Marcy l Etoile, France
    Biochem Pharmacol 49:1717-20. 1995
    The thioesterification of fenoprofen (FPF) by rat liver microsomes has been studied using an HPLC method enabling direct quantification of the FPF-CoA produced...
  38. ncbi The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells
    Emily J Quann
    Department of Biochemistry and Molecular and Cellular Biology and the Vincent T Lombardi Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA
    Cancer Res 67:3254-62. 2007
    ..for induction of p75(NTR) and decreased survival, in rank-order, were R-flurbiprofen, ibuprofen, oxaprozin, fenoprofen, naproxen, and ketoprofen...
  39. ncbi Prediction of selectivity for enantiomeric separations of uncharged compounds by capillary electrophoresis involving dual cyclodextrin systems
    Adel M Abushoffa
    Department of Analytical Pharmaceutical Chemistry, Institute of Pharmacy, University of Liege, CHU, B 36, Avenue de l Hopital 1, B 4000 Liege, Belgium
    J Chromatogr A 948:321-9. 2002
    ..has been tested as chiral additive for the enantioseparation of non-steroidal anti-inflammatory drugs, such as fenoprofen, flurbiprofen, ibuprofen and ketoprofen, in capillary electrophoresis, using a pH 2...
  40. doi Non-steroidal anti-inflammatory agents for treating cystoid macular oedema following cataract surgery
    Sobha Sivaprasad
    Normanby Building, King s CollegeHospital, London, UK
    Cochrane Database Syst Rev 2:CD004239. 2012
    ..CMO that persists for four months or more is termed chronic CMO. Different types of non-steroidal anti-inflammatory agents (NSAIDs) are used in the treatment of CMO which may be delivered topically or systemically...
  41. ncbi Antioxidant activity and inhibition of human neutrophil oxidative burst mediated by arylpropionic acid non-steroidal anti-inflammatory drugs
    David Costa
    REQUIMTE, Departamento de Quimica Fisica, Faculdade de Farmacia, Universidade do Porto, Portugal
    Biol Pharm Bull 29:1659-70. 2006
    ..oxidative burst), mediated by the arylpropionic acid derivatives (APAs) NSAIDs ibuprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, naproxen and indoprofen...
  42. ncbi Detection of pharmaceutical contaminations of river, pond, and tap water from Cologne (Germany) and surroundings
    Ulrich Jux
    Institut fur Medizinische Mikrobiologie, Immunologie und Hygiene, Universitat zu Koln, Goldenfelsstrasse 19 21, D 50935 Köln, Germany
    Int J Hyg Environ Health 205:393-8. 2002
    ..Clofibrat, Etofibrat, Etofyllinclofibrat), antirheumatics (Diclofenac, Ibuprofen, Ketoprofen, Indomethacin, Fenoprofen) and Sarkosin-N-(phenylsulfonyl) (SPS), a metabolite of a corrosion inhibiting agent...
  43. ncbi Chiral inversion of (R)-(-)-fenoprofen in guinea-pigs pretreated with clofibrate
    M F San Martin
    Departamento de Fisiopatologia, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Paraje Arroyo Seco s n Tandil, Argentina
    Vet Res Commun 26:323-32. 2002
    The influence of clofibrate on the stereoconversion of fenoprofen (FPF) was studied in guinea pigs. This hypolipidaemic agent has been related to some biochemical changes in the liver leading to an increase in the chiral inversion process...
  44. ncbi Pharmaceutical chemicals and endocrine disrupters in municipal wastewater in Tokyo and their removal during activated sludge treatment
    Norihide Nakada
    Laboratory of Organic Geochemistry LOG, Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183 8509, Japan
    Water Res 40:3297-303. 2006
    We measured six acidic analgesics or anti-inflammatories (aspirin, ibuprofen, naproxen, ketoprofen, fenoprofen, mefenamic acid), two phenolic antiseptics (thymol, triclosan), four amide pharmaceuticals (propyphenazone, crotamiton, ..
  45. ncbi Hyaluronidase inhibitors (sodium cromoglycate and sodium auro-thiomalate) reduce the local tissue damage and prolong the survival time of mice injected with Naja kaouthia and Calloselasma rhodostoma venoms
    Senee Yingprasertchai
    Department of Microbiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    Toxicon 42:635-46. 2003
    ..sodium cromoglycate (SC), sodium aurothiomalate (SAT), apigenin, kaemferol, phenylbutazone, oxyphenbutazone and fenoprofen. The results showed that SC or SAT at 10 mM, completely inhibited the enzymes of both venoms...
  46. doi Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants
    I Perković
    Faculty of Pharmacy and Biochemistry, University of Zagreb, A Kovacica 1, HR 10 000 Zagreb, Croatia
    Eur J Med Chem 51:227-38. 2012
    ..8a-f) derived from the nonsteroidal anti-inflammatory drugs ibuprofen, fenoprofen and reduced ketoprofen were prepared, fully chemically characterized and evaluated for their cytostatic, ..
  47. pmc Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs
    Kathleen M Knights
    Department of Clinical Pharmacology, Flinders University, School of Medicine, Bedford Park, Adelaide 5042, Australia
    Br J Clin Pharmacol 68:402-12. 2009
    ....
  48. doi Enantiomeric separation of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs by HPLC with hydroxypropyl-beta-cyclodextrin as chiral mobile phase additive
    Jincui Ye
    Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, People s Republic of China
    Biomed Chromatogr 24:799-807. 2010
    ..phase additive for studying the stereoselective skin permeation of suprofen, ketoprofen, naproxen, indoprofen, fenoprofen, furbiprofen, ibuprofen and carprofen...
  49. doi Synthesis of dehydroabietic acid-modified chitosan and its drug release behavior
    Wengui Duan
    School of Chemistry and Chemical Engineering, Guangxi University, No 100, Daxue Road, Nanning, Guangxi 530004, People s Republic of China
    Carbohydr Res 344:9-13. 2009
    ..The degree of substitution (DS) of DAMC was 16.5%. And chitosan and DAMC were used as carriers of fenoprofen calcium (FC), and their controlled release behavior in artificial intestinal juice was studied...
  50. doi Antioxidant activity of NSAID hydroxamic acids
    Marijana Zovko Koncic
    Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
    Acta Pharm 59:235-42. 2009
    ..present study, seven hydroxamic acid derivatives of nonsteroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, fenoprofen, ketoprofen, indomethacin and diclofenac) were found to possess significant antioxidant, radical scavenging and ..
  51. ncbi Chiral inversion of R(-) fenoprofen and ketoprofen enantiomers in cats
    E Castro
    Departamento de Fisiopatologia, Area de Toxicología, Campus Universitario, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil 7000, Argentina
    J Vet Pharmacol Ther 23:265-71. 2000
    ..In this study, R(-) fenoprofen [R(-)FPF] and R(-) ketoprofen [R(-) KTF] were used to investigate their comparative stereoconversion in cats...
  52. doi Synthesis and biological evaluation of O-methyl and O-ethyl NSAID hydroxamic acids
    Zrinka Rajic
    Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
    J Enzyme Inhib Med Chem 24:1179-87. 2009
    ..Ibuprofen and fenoprofen hydroxamic acids with free hydroxy groups present the highest antimicrobial activity, while indomethacin and ..
  53. ncbi Determination of nonsteroidal antiinflammatory drugs in water samples using liquid chromatography coupled with diode-array detector and mass spectrometry
    Jolanta Debska
    Department of Analytical Chemistry, Chemical Faculty, Gdansk University of Technology, Poland
    J Sep Sci 28:2419-26. 2005
    ..RSD value is relatively low (from 4% for fenoprofen up to 8% for ibuprofen). The performance of the method was tested with several environmental water samples.
  54. doi Robust open tubular layer of S-ketoprofen imprinted polymer for chiral LC separation
    Shabi Abbas Zaidi
    Department of Chemistry, Nano Fine Center and Institute of Basic Research, Inha University, Incheon, South Korea
    J Sep Sci 31:2962-70. 2008
    ..Our MIP capillary column also showed some versatility in chiral separation, thus a good chiral separation was observed for naproxen, ibuprofen, and fenoprofen enantiomers.
  55. doi General method for the (11)C-labeling of 2-arylpropionic acids and their esters: construction of a PET tracer library for a study of biological events involved in COXs expression
    Misato Takashima-Hirano
    RIKEN Center for Molecular Imaging Science CMIS, 6 7 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo, 650 0047, Japan
    Chemistry 16:4250-8. 2010
    ..this method in the syntheses of six PET tracers, [(11)C]Ibuprofen, [(11)C]Naproxen, [(11)C]Flurbiprofen, [(11)C]Fenoprofen, [(11)C]Ketoprofen, and [(11)C]Loxoprofen...
  56. ncbi Synthesis and in vitro antitumor effect of diclofenac and fenoprofen thiolated and nonthiolated polyaspartamide-drug conjugates
    M Barbaric
    Faculty of Pharmacy and Biochemistry, University of Zagreb, A Kovacica 1, HR 10000 Zagreb, Croatia
    Eur J Med Chem 42:20-9. 2007
    This paper reports the synthesis and antiproliferative effects of new thiomer-diclofenac and fenoprofen conjugates, hydrophilic, bioadhesive, polymeric prodrugs, as well as antiproliferative effects of diclofenac, fenoprofen and a series ..
  57. ncbi Immunomodulatory effect of nonsteroidal anti-inflammatory drugs (NSAIDs) at the clinically available doses
    Jae Youl Cho
    School of Bioscience and Biotechnology and Korean Nutritional Science Institute, Kangwon National University, Chuncheon 200 701, Korea
    Arch Pharm Res 30:64-74. 2007
    ..7 cells at certain concentrations (fenoprofen, indomethacin, piroxicam, aceclofenac, diclofenac and sulindac) or in a dose-dependent manner (aspirin and ..
  58. doi Rapid simultaneous determination of four non-steroidal anti-inflammatory drugs by means of derivative nonlinear variable-angle synchronous fluorescence spectrometry
    José A Murillo Pulgarín
    Department of Analytical Chemistry and Foods Technology, University of Castilla La Mancha, 13071 Ciudad Real, Spain
    Appl Spectrosc 64:949-55. 2010
    ..spectrofluorimetric method has been proposed for the simultaneous quantification of diflunisal, salicylic acid, fenoprofen, and 6-methoxy-2-naphthylacetic acid (6MNA)...
  59. doi The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations
    K Wittine
    Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulicev trg 20, HR 10000 Zagreb, Croatia
    Eur J Med Chem 44:143-51. 2009
    ..5a-e were prepared in one step from 3-hydroxypropyl derivatives 3a-e of nonsteroidal anti-inflammatory drugs (fenoprofen, ketoprofen, ibuprofen, indomethacin, diclofenac)...
  60. ncbi Fenoprofen and ketoprofen amides as potential antitumor agents
    Marko Marjanović
    Chem Biol Drug Des 69:222-6. 2007
    ..b>Fenoprofen and ketoprofen showed modest antiproliferative activity, whereas the growth inhibitory activity of the tested ..
  61. doi Occurrence and risk assessment of acidic pharmaceuticals in the Yellow River, Hai River and Liao River of north China
    Li Wang
    State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China
    Sci Total Environ 408:3139-47. 2010
    ..of twelve acidic pharmaceuticals and herbicides (salicylic acid, clofibric acid, ibuprofen, gemfibrozil, fenoprofen, naproxen, ketoprofen, mefenamic acid, tolfenamic acid, diclofenac, meclofenamic acid and indomethacin) in ..
  62. doi A highly sensitive method for enantioseparation of fenoprofen and amino acid derivatives by capillary electrophoresis with on-line sample preconcentration
    Zhaoyan Wang
    Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Lingling Road 345, Shanghai, China
    J Chromatogr A 1218:1775-9. 2011
    A highly sensitive method for enantioseparation of trace fenoprofen and amino acid derivatives by capillary electrophoresis (CE) with vancomycin as the chiral selector was developed...
  63. doi Role of biodegradation in the removal of pharmaceutically active compounds with different bulk organic matter characteristics through managed aquifer recharge: batch and column studies
    Sung Kyu Maeng
    Water Research Center, Korea Institute of Science and Technology, P O BOX 131, Cheongryang, Seoul 130 650, South Korea
    Water Res 45:4722-36. 2011
    ..Neutral PhACs (phenacetine, paracetamol, and caffeine) and acidic PhACs (ibuprofen, fenoprofen, bezafibrate, and naproxen) were removed with efficiencies greater than 88% from different organic matter water ..
  64. doi A combination of statistical and analytical evaluation methods as a new optimization strategy for the quantification of pharmaceutical residues in sewage effluent
    Eliane A Suchara
    Departamento de Quimica, Universidade Federal de Santa Catarina, Florianopolis, SC 88040 900, Brazil
    Anal Chim Acta 613:169-76. 2008
    ..method for simultaneous extraction of pharmaceutical compounds with acidic and basic characteristics (ibuprofen, fenoprofen, diclofenac, diazepam and loratadine) from residual water samples is proposed...
  65. pmc Efficient, selective, and green: catalyst tuning for highly enantioselective reactions of ethylene
    Craig R Smith
    Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA
    Org Lett 10:1657-9. 2008
    ..are among the highest for all asymmetric catalytic processes reported to date for the synthesis of intermediates for the widely used antiinflammatory 2-arylpropionic acids including naproxen, ibuprofen, fenoprofen, and flurbiprofen.
  66. ncbi In vitro enantioselective glucuronidation of fenoprofen
    C Volland
    Department of Pharmacy, School of Pharmacy, University of California, San Francisco
    Pharmacology 43:53-60. 1991
    The diastereomeric glucuronic acid conjugates are major metabolites of the nonsteroidal anti-inflammatory drug fenoprofen (FEN)...
  67. ncbi Studies on the effect of fenoprofen on the activation and oxidation of long chain and very long chain fatty acids in hepatocytes and subcellular fractions from rat liver
    W Lageweg
    Department of Clinical Biochemistry, University of Amsterdam, The Netherlands
    Biochem Pharmacol 46:79-85. 1993
    We studied the effect of fenoprofen on the activation of palmitic acid (C16:0), lignoceric acid (C24:0) and cerotic acid (C26:0) in microsomal and peroxisomal fractions from rat liver...
  68. ncbi Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin
    A Bischer
    Department of Pharmacy, University of California, San Francisco 94143 0446, USA
    Drug Metab Dispos 23:900-3. 1995
    The stereoselective binding of fenoprofen enantiomers and fenoprofen glucuronide diastereomers to human serum albumin (HSA) was investigated using an ultrafiltration method...
  69. ncbi Chiral inversion of fenoprofen in horses and dogs: an in vivo-in vitro study
    A Soraci
    Unité associée INRA DGER de toxicologie métabolique, Ecole Veterinaire de Lyon, Marcy l Etoile, France
    Vet Res 27:13-22. 1996
    b>Fenoprofen (FPF) is a chiral non-steroid antiinflammatory drug, marketed as a racemic mixture of its R(-) and S(+) enantiomers...
  70. ncbi Calculation of inversion half-lives of aryl propionic acid class nonsteroidal antiinflammatory drugs
    D Kantoci
    Department of Medicine, School of Medicine, Loma Linda University, California 92350, USA
    J Clin Pharmacol 36:500-4. 1996
    ..animal data, we have mathematically determined the inversion half-life (t1/2i) for ibuprofen, ketoprofen, and fenoprofen. The relation of the sensitivity of this value to the terminal half-life (t1/2) of the R-enantiomers of APA ..
  71. ncbi Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    J M Lehmann
    Department of Molecular Endocrinology, Glaxo Wellcome Research and Development, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 272:3406-10. 1997
    ..We demonstrate that several other NSAIDs, including fenoprofen, ibuprofen, and flufenamic acid, are also PPARgamma ligands and induce adipocyte differentiation of C3H10T1/2 ..
  72. ncbi Stereospecific formulation and characterization of sustained release ibuprofen microspheres
    R K Janjikhel
    Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA
    J Microencapsul 14:409-26. 1997
    ..were analysed by a stereospecific HPLC assay using S-(-)-1(1) naphthylethylamine as the derivatizing agent and fenoprofen as the internal standard...
  73. ncbi Involvement of the rat gut epithelial and muscular layer, and microflora in chiral inversion and acyl-glucuronidation of R-fenoprofen
    S Sattari
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada
    Eur J Drug Metab Pharmacokinet 22:97-101. 1997
    In the presence of excised human and rat gut, the pharmacologically inactive R enantiomers of both ibuprofen and fenoprofen (FN) are bioinverted to their anti-inflammatory antipodes...
  74. ncbi Measurement of plasma ibuprofen by gas chromatography-mass spectrometry
    B A Way
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Clin Lab Anal 11:336-9. 1997
    ..0 +/- 6.5 mg/L). This method is suited for routine clinical use for the monitoring of plasma ibuprofen levels in treatment of CF. It may be particularly applicable in pediatric laboratories, which are likely to possess GC-MS capability...
  75. ncbi Stereochemistry and dynamics of the inclusion complex of (S)-(+)-fenoprofen with cyclomaltoheptaose (beta-cyclodextrin)
    G Uccello-Barretta
    Centro di Studio del CNR per le Macromolecole Stereordinate ed Otticamente Attive, Dipartimento di Chimica e Chimica Industriale, Pisa, Italy
    Carbohydr Res 243:1-10. 1993
    ..Measurements of proton selective relaxation rates allowed the dynamics of the complex to be investigated and the determination of intermolecular 1H(1H)-NOE enhancements revealed the stereochemistry in solution...
  76. ncbi A liquid chromatographic method for the determination of fenoprofen in equine plasma and urine
    F T Delbeke
    Faculteit Diergeneeskunde, Universiteit Gent, Belgium
    Biomed Chromatogr 8:29-31. 1994
    A high performance liquid chromatographic method to measure plasma and urine fenoprofen levels in equine biofluids is described. Liquid-liquid extraction with diethylether was used to isolate the drug from plasma and urine...
  77. ncbi Antiproliferative effect of nonsteroidal antiinflammatory drugs against human colon cancer cells
    L J Hixson
    Department of Medicine, University of Arizona, Tucson 85724
    Cancer Epidemiol Biomarkers Prev 3:433-8. 1994
    ..A cytostatic response was demonstrated with sulindac sulfide. These data further support the potential role of these agents for chemoprevention of colorectal neoplasia...
  78. ncbi Assessment of the drug inhibitor specificity of the human liver 4-methylumbelliferone UDP-glucuronosyltransferase activity
    J O Miners
    Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, Adelaide, Australia
    Biochem Pharmacol 41:838-41. 1991
    ..However, confirmation of this ultimately requires studies to be performed with purified isozymes, cDNAs expressed in cell culture, or specific inhibitory antibodies...
  79. ncbi Stereoselective analysis of fenoprofen and its metabolites
    C Volland
    Department of Pharmacy, School of Pharmacy, University of California San Francisco 94143 0446
    J Chromatogr 534:127-38. 1990
    Reversed-phase high-performance liquid chromatographic assays have been developed to quantitate simultaneously fenoprofen and its major metabolites as well as to distinguish between their R- and S- enantiomers following a single oral dose ..
  80. ncbi Nonsteroidal anti-inflammatory drugs and coma: a case report of fenoprofen overdose
    J M Kolodzik
    Department of Emergency Medicine, Wright State University, School of Medicine, Dayton, Ohio 45401 0927
    Ann Emerg Med 19:378-81. 1990
    We present the case of a 17-year-old girl who ingested 24 to 36 g fenoprofen as a suicidal gesture. She presented with coma, hypotension, metabolic acidosis, and respiratory depression within four hours of ingestion...
  81. ncbi Oral manifestations of drug therapies in the geriatric patient
    A E Segelman
    Tufts University School of Dental Medicine, Boston, Massachusetts
    Dent Clin North Am 33:67-73. 1989
    ....
  82. ncbi Stereospecific high-performance liquid chromatographic (HPLC) assay of fenoprofen enantiomers in plasma and urine
    R Mehvar
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada
    Pharm Res 5:53-6. 1988
    A new high-performance liquid chromatographic (HPLC) assay suitable for pharmacokinetic studies of enantiomers of fenoprofen (FEN) was developed...
  83. ncbi High-performance liquid chromatographic quantitation of triacylglycerols containing fenoprofen from biological samples
    B C Sallustio
    Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, Australia
    J Chromatogr 422:33-41. 1987
    ..HPLC) method has been developed for the quantitation of radiolabelled triacylglycerols containing fenoprofen, synthesized from [3H]glycerol by isolated hepatocytes and adipocytes...
  84. ncbi In vitro fenoprofenyl-coenzyme A thioester formation: interspecies variations
    A Soraci
    Department of Metabolic Toxicology, School of Veterinary Medicine of Lyon, Marcy l Etoile, France
    Chirality 7:534-40. 1995
    In vitro coenzyme A thioester formation from (-)-(R)-fenoprofen (FPF) and palmitic acid has been studied using liver microsomes from rat, guinea pig, sheep, and dog...
  85. ncbi Joint space measurement in hand radiographs using computerized image analysis
    M F James
    SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK
    Arthritis Rheum 38:891-901. 1995
    ..To compare computerized joint space (JS) measurements with conventional joint space narrowing (JSN) scores in patients with mild rheumatoid arthritis...
  86. ncbi Multi-site binding of fenoprofen to human serum albumin studied by a combined technique of microdialysis with high performance liquid chromatography
    H Wang
    National Chromatographic R and A Centre, Dalian Institute of Chemical Physics, Academia Sinica, Dalian, Peoples Republic of China
    Biomed Chromatogr 12:4-7. 1998
    A simple and fast method for the determination of the multi-site binding of fenoprofen (FP) to human serum albumin (HSA) has been developed by utilizing microdialysis sampling techniques combined with high performance liquid ..
  87. ncbi Tissue extraction and high-performance liquid chromatographic determination of ketoprofen entantiomers
    P C Panus
    Department of Physical Therapy, College of Public and Allied Health, East Tennessee State University, Johnson City 37614 0624, USA
    J Chromatogr B Biomed Sci Appl 705:295-302. 1998
    ..This represents the first non-radioactive method for determination of ketoprofen in tissues following transcutaneous iontophoresis...
  88. ncbi Physical stability and solubility of the thermotropic mesophase of fenoprofen calcium as pure drug and in a tablet formulation
    James Patterson
    Solid State Research Group, School of Pharmacy, University of Otago, Dunedin, New Zealand
    Int J Pharm 247:147-57. 2002
    ..study was to investigate and compare the physical stability and solubility of the liquid crystalline form of fenoprofen calcium as pure drug and in a proprietary tablet formulation (Nalfon), and to investigate if a simple heat ..
  89. ncbi Enhancement of selectivity and resolution in the enantioseparation of uncharged compounds using mixtures of oppositely charged cyclodextrins in capillary electrophoresis
    Adel M Abushoffa
    Department of Analytical Pharmaceutical Chemistry, Institute of Pharmacy, University of Liege, Liege, Belgium
    Electrophoresis 24:343-50. 2003
    ....
  90. ncbi [Study on the release mechanism of fenoprofen calcium from hydrophillic sustained-release matrix]
    C S Zhao
    Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110015, China
    Yao Xue Xue Bao 36:63-6. 2001
    To study the release mechanism of fenoprofen calcium (FC) from hydroxypropylmethylcellulose (HPMC) matrices.
  91. ncbi Coenzyme A esters of 2-aryloxyphenoxypropionate herbicides and 2-arylpropionate antiinflammatory drugs are potent and stereoselective inhibitors of rat liver acetyl-CoA carboxylase
    C Kemal
    Department of Entomological Sciences, University of California, Berkeley 94720
    Life Sci 50:533-40. 1992
    ..The CoA esters of the antiinflammatory drugs ibuprofen and fenoprofen also strongly inhibit this carboxylase. (S)-Ibuprofenyl-CoA (Ki = 0...
  92. ncbi Application of capillary electrophoresis with different sample stacking strategies for the determination of a group of nonsteroidal anti-inflammatory drugs in the low microg x L(-1) concentration range
    Alba Macià
    Departament de Quimica Analitica i Quimica Organica, Universitat Rovira i Virgili, Tarragona, Spain
    Electrophoresis 25:428-36. 2004
    ..LVSEP, LVSEP-ASEI, and FAEP improved the sensitivity of the peak area by 100-, 1200-, and 1800-fold, respectively. The methodology developed, in combination with solid-phase extraction (SPE), was applied to the analysis of water samples...
  93. ncbi Enantioselective kinetic disposition of fenoprofen in rats with experimental diabetes or adjuvant-induced arthritis
    Josiane Cristófani Poggi
    Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, SP, Brazil
    Pharmacology 72:85-91. 2004
    ..investigate the influence of diabetes or arthritis on the enantioselective metabolism and kinetic disposition of fenoprofen in rats with streptozotocin-induced diabetes or Mycobacteriumtuberculosis adjuvant-induced arthritis...
  94. ncbi Cationic vesicles as chiral selector for enantioseparations of nonsteroidal antiinflammatory drugs by micellar electrokinetic chromatography
    Joykrishna Dey
    Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India
    J Chromatogr A 1048:127-32. 2004
    ..g., carprofen, flurbiprofen, fenoprofen, ibuprofen, indoprofen, ketoprofen, naproxen and suprofen by capillary electrophoresis...
  95. ncbi Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity
    Clare J Strachan
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
    J Pharm Sci 94:837-46. 2005
    ..maleate polymorphs, amorphous, and crystalline indomethacin, and thermotropic liquid crystalline and crystalline fenoprofen calcium mixtures were quantified using partial least-squares analysis...
  96. ncbi Identification of 8-iso-prostaglandin F(2alpha) in rat brain neuronal endings: a possible marker of membrane phospholipid peroxidation
    Luigi Brunetti
    Department of Drug Sciences, G D Annunzio University, Via dei Vestini, 66013, Chieti, Italy
    Life Sci 71:2447-55. 2002
    ..Synaptosome treatment with a non-selective cyclooxygenase inhibitor (fenoprofen) did not modify 8-iso-PGF(2alpha) release in any way, but treatment with a water soluble antioxidant (Trolox C) ..
  97. ncbi Macromolecular prodrugs. IX. Synthesis of polymer-fenoprofen conjugates
    M Zovko
    Faculty of Pharmacy and Biochemistry, University of Zagreb, A Kovacica, 1, 10000, Zagreb, Croatia
    Int J Pharm 228:129-38. 2001
    Synthesis of several polymer-fenoprofen conjugates is described...
  98. ncbi Enantioselective inhibition of the binding of rac-profens to human serum albumin induced by lithocholate
    C Bertucci
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, 40126 Bologna, Italy
    Chirality 13:372-8. 2001
    ....
  99. ncbi Interactions between fenoprofen sodium and poly (ethylene oxide)
    T Rades
    University of Otago, Dunedin, New Zealand
    Eur J Pharm Biopharm 46:51-9. 1998
    Interactions of the amphiphilic drug fenoprofen sodium (FNa) in solution below and above its critical micelle concentration with poly (ethylene oxide) (PEO) of different chain length (PEO 400 to PEO 20000) and between a liquid crystalline ..
  100. ncbi Study of the binding in an aqueous medium of inclusion complexes of several cyclodextrins involving fenoprofen calcium
    D Diaz
    Facultad de Quimica, Departamento de Quimica Inorganica, UNAM, Delegacion Coyoacan, Mexico
    Drug Dev Ind Pharm 25:107-10. 1999
    Interactions among fenoprofen calcium and alpha-, beta-, gamma- and hydroxypropyl-beta-cyclodextrins (HP-beta-CD) were evaluated in aqueous solution by UV/vis and fluorescence direct spectroscopies and monodimensional (1D) 1H-NMR...
  101. ncbi In vitro study of fenoprofen chiral inversion in rat: comparison of brain versus liver
    C Sevoz
    Unité associée de Toxicologie et Métabolisme Comparés des Xénobiotiques DGER INRA, Ecole Nationale Veterinaire de Lyon, France
    Xenobiotica 29:1007-16. 1999
    The extent and the overall stereoselectivity of the combined steps involved in the chiral inversion of fenoprofen, a non-steroidal anti-inflammatory drug, was investigated in rat brain microsomes and cytosol...

Research Grants4

  1. ACYL GLUCURONIDES: COVALENT BINDING & PHARMACOKINETICS
    Leslie Benet; Fiscal Year: 1993
    ..will study acyl glucuronides of several commonly used acidic drugs (tolmetin, naproxen, carprofen, ibuprofen and fenoprofen), as well as drugs of known serious toxicity to humans (zomepirac and benoxaprofen), some experimental (..
  2. GUSTATORY AND OLFACTORY CHANGES WITH AGE
    SUSAN SCHIFFMAN; Fiscal Year: 2005
    ..abstract_text> ..