diclofenac

Summary

Summary: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.

Top Publications

  1. ncbi Toxic effects of the non-steroidal anti-inflammatory drug diclofenac. Part I: histopathological alterations and bioaccumulation in rainbow trout
    J Schwaiger
    Department of Aquatic Ecology Research, Bavarian Water Management Agency, Demollstr 31, 82407 Wielenbach, Germany
    Aquat Toxicol 68:141-50. 2004
  2. ncbi Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial
    Francis K L Chan
    Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Lancet 376:173-9. 2010
  3. ncbi Using laser microporation to improve transdermal delivery of diclofenac: Increasing bioavailability and the range of therapeutic applications
    Yogeshwar G Bachhav
    School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Geneva, Switzerland
    Eur J Pharm Biopharm 78:408-14. 2011
  4. ncbi Randomized controlled trial of diclofenac sodium gel in knee osteoarthritis
    H Richard Barthel
    Semin Arthritis Rheum 39:203-12. 2009
  5. ncbi Diclofenac residues as the cause of vulture population decline in Pakistan
    J Lindsay Oaks
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    Nature 427:630-3. 2004
  6. ncbi Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2
    Patricia McGettigan
    Discipline of Clinical Pharmacology, School of Medicine and Public Health, The University of Newcastle, New South Wales, Australia
    JAMA 296:1633-44. 2006
  7. ncbi Diclofenac sodium delivery to the eye: in vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct
    Anthony A Attama
    Institut fur Pharmazeutische Technologie, Technische Universität Carolo Wilhelmina zu Braunschweig, Mendelssohnstrasse 1, D 38106 Braunschweig, Germany
    Int J Pharm 355:307-13. 2008
  8. ncbi Analysis of the effects diclofenac has on Japanese medaka (Oryzias latipes) using real-time PCR
    Han Na Hong
    National Research Laboratory on Environmental Biotechnology, Gwangju Institute of Science and Technology GIST, Gwangju, South Korea
    Chemosphere 67:2115-21. 2007
  9. ncbi Diclofenac in fish: blood plasma levels similar to human therapeutic levels affect global hepatic gene expression
    Filip Cuklev
    Sahlgrenska Academy at the University of Gothenburg, Goteborg, Sweden
    Environ Toxicol Chem 30:2126-34. 2011
  10. ncbi Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity
    Guruprasad P Aithal
    School of Clinical Medical Sciences Hepatology, Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Hepatology 39:1430-40. 2004

Research Grants

Detail Information

Publications363 found, 100 shown here

  1. ncbi Toxic effects of the non-steroidal anti-inflammatory drug diclofenac. Part I: histopathological alterations and bioaccumulation in rainbow trout
    J Schwaiger
    Department of Aquatic Ecology Research, Bavarian Water Management Agency, Demollstr 31, 82407 Wielenbach, Germany
    Aquat Toxicol 68:141-50. 2004
    ..The non-steroidal inflammatory drug diclofenac represents one of the most commonly detected compounds...
  2. ncbi Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial
    Francis K L Chan
    Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Lancet 376:173-9. 2010
    ..We aimed to compare risk of gastrointestinal events associated with celecoxib versus diclofenac slow release plus omeprazole.
  3. ncbi Using laser microporation to improve transdermal delivery of diclofenac: Increasing bioavailability and the range of therapeutic applications
    Yogeshwar G Bachhav
    School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Geneva, Switzerland
    Eur J Pharm Biopharm 78:408-14. 2011
    ..L.E.A.S.E.® technology, on diclofenac delivery kinetics...
  4. ncbi Randomized controlled trial of diclofenac sodium gel in knee osteoarthritis
    H Richard Barthel
    Semin Arthritis Rheum 39:203-12. 2009
    ..This study assessed the efficacy and safety of topical diclofenac sodium 1% gel (DSG) in mild to moderate symptomatic knee osteoarthritis.
  5. ncbi Diclofenac residues as the cause of vulture population decline in Pakistan
    J Lindsay Oaks
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    Nature 427:630-3. 2004
    ..Here, we provide results that directly correlate residues of the anti-inflammatory drug diclofenac with renal failure...
  6. ncbi Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2
    Patricia McGettigan
    Discipline of Clinical Pharmacology, School of Medicine and Public Health, The University of Newcastle, New South Wales, Australia
    JAMA 296:1633-44. 2006
    ..Regulatory agencies have provided variable advice regarding the cardiovascular risks with older nonselective NSAIDs...
  7. ncbi Diclofenac sodium delivery to the eye: in vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct
    Anthony A Attama
    Institut fur Pharmazeutische Technologie, Technische Universität Carolo Wilhelmina zu Braunschweig, Mendelssohnstrasse 1, D 38106 Braunschweig, Germany
    Int J Pharm 355:307-13. 2008
    ..SLNs) were prepared with a combination of homolipid from goat (goat fat) and phospholipid, and evaluated for diclofenac sodium (DNa) delivery to the eye using bio-engineered human cornea, produced from immortalized human corneal ..
  8. ncbi Analysis of the effects diclofenac has on Japanese medaka (Oryzias latipes) using real-time PCR
    Han Na Hong
    National Research Laboratory on Environmental Biotechnology, Gwangju Institute of Science and Technology GIST, Gwangju, South Korea
    Chemosphere 67:2115-21. 2007
    ..P450 1A, p53 and vitellogenin were investigated in three different tissues of male medaka fish after exposure to diclofenac that is one of the main concerns among pharmaceuticals frequently found in sewage treatment plant (STP) ..
  9. ncbi Diclofenac in fish: blood plasma levels similar to human therapeutic levels affect global hepatic gene expression
    Filip Cuklev
    Sahlgrenska Academy at the University of Gothenburg, Goteborg, Sweden
    Environ Toxicol Chem 30:2126-34. 2011
    b>Diclofenac is a nonsteroidal anti-inflammatory drug frequently found in the aquatic environment...
  10. ncbi Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity
    Guruprasad P Aithal
    School of Clinical Medical Sciences Hepatology, Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Hepatology 39:1430-40. 2004
    b>Diclofenac is a nonsteroidal anti-inflammatory drug that causes rare but serious hepatotoxicity, the mechanism of which is unclear. The purpose of the present study was to explore the potential role played by the immune processes...
  11. ncbi The nonsteroidal antiinflammatory drug diclofenac potentiates the in vivo activity of caspofungin against Candida albicans biofilms
    Anna Bink
    Center of Microbial and Plant Genetics, KU Leuven, Heverlee, Belgium
    J Infect Dis 206:1790-7. 2012
    In this study, we demonstrated that in vitro Candida albicans biofilms grown in the presence of diclofenac showed increased susceptibility to caspofungin...
  12. ncbi Diclofenac: an update on its mechanism of action and safety profile
    Tong J Gan
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Med Res Opin 26:1715-31. 2010
    b>Diclofenac is a proven, commonly prescribed nonsteroidal anti-inflammatory drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain ..
  13. ncbi Pilot study of intravitreal injection of diclofenac for treatment of macular edema of various etiologies
    Masoud Soheilian
    Ophthalmology Department and Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University MC, Tehran, Iran
    Retina 30:509-15. 2010
    The purpose of this study was to evaluate the effect of a single dose of intravitreal diclofenac, a potent nonsteroidal antiinflammatory drug, on visual acuity and central macular thickness in patients with macular edema of various ..
  14. ncbi Efficacy of a comfrey root extract ointment in comparison to a diclofenac gel in the treatment of ankle distortions: results of an observer-blind, randomized, multicenter study
    H G Predel
    Merck Selbstmedikation GmbH, Roesslerstr 96, D 64293 Darmstadt, Germany
    Phytomedicine 12:707-14. 2005
    ..Rad. Symphyti) with that of a Diclofenac gel in the treatment of acute unilateral ankle sprain (distortion)...
  15. ncbi Developmental toxicity and stress protein responses in zebrafish embryos after exposure to diclofenac and its solvent, DMSO
    A V Hallare
    Animal Physiological Ecology Section, Zoological Institute, University of Tubingen, Konrad Adenauer Str 20, D 72072, Tubingen, Germany
    Chemosphere 56:659-66. 2004
    One of the most frequently detected pharmaceuticals in environmental water samples is the anti-rheumatic drug, diclofenac. Despite its increasing environmental significance, investigations concerning the effects of this drug on the early ..
  16. ncbi Cardiovascular safety of lumiracoxib: a meta-analysis of all randomized controlled trials > or =1 week and up to 1 year in duration of patients with osteoarthritis and rheumatoid arthritis
    Patrice Matchaba
    Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA
    Clin Ther 27:1196-214. 2005
    ..The cardiovascular (CV) safety of non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 inhibitors has been the subject of considerable debate...
  17. ncbi Efficacy and safety of topical diclofenac containing dimethyl sulfoxide (DMSO) compared with those of topical placebo, DMSO vehicle and oral diclofenac for knee osteoarthritis
    Lee S Simon
    SDG LLC Consulting, 124 Mt Auburn Street, Cambridge, MA, USA
    Pain 143:238-45. 2009
    ..We conducted a 12-week, double-blind, double-dummy, randomized controlled trial of topical diclofenac (TDiclo) in a vehicle solution containing dimethyl sulfoxide (DMSO) in 775 subjects with radiologically ..
  18. ncbi Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative
    Ling Li
    Cardiovascular Biology Research Group, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 18 Medical Drive, Singapore 117597
    Free Radic Biol Med 42:706-19. 2007
    S-diclofenac (2-[(2,6-dichlorophenyl)amino]benzeneacetic acid 4-(3H-1,2,dithiol-3-thione-5-yl)phenyl ester; ACS 15) is a novel molecule comprising a hydrogen sulfide (H2S)-releasing dithiol-thione moiety attached by an ester linkage to ..
  19. ncbi Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes
    Ann K Daly
    School of Clinical and Laboratory Sciences, University of Newcastle Medical School, Framlington Place, Newcastle upon Tyne, UK
    Gastroenterology 132:272-81. 2007
    b>Diclofenac is a widely used nonsteroidal anti-inflammatory drug and is among the most common drugs causing idiosyncratic hepatotoxicity in several recent series with up to 20% mortality in jaundiced subjects...
  20. ncbi Effect of sodium chloride on the gelation temperature, gel strength and bioadhesive force of poloxamer gels containing diclofenac sodium
    C S Yong
    College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyongsan 712-749, South Korea
    Int J Pharm 226:195-205. 2001
    ..However, a liquid suppository system containing diclofenac sodium could not be developed using bioadhesive polymers, since the drug was precipitated in this preparation...
  21. ncbi Physiological effects of diclofenac, ibuprofen and propranolol on Baltic Sea blue mussels
    Hanna Ericson
    Department of Systems Ecology, Stockholm University, Svante Arrhenius Väg 21A, S 106 91 Stockholm, Sweden
    Aquat Toxicol 99:223-31. 2010
    ..In this study, Baltic Sea blue mussels, Mytilus edulis trossulus, were exposed to diclofenac, ibuprofen and propranolol, three pharmaceuticals that are produced and sold in large quantities and have a ..
  22. ncbi Safety and efficacy of topical diclofenac sodium gel for knee osteoarthritis in elderly and younger patients: pooled data from three randomized, double-blind, parallel-group, placebo-controlled, multicentre trials
    Herbert S B Baraf
    Center for Rheumatology and Bone Research, a division of the Arthritis and Rheumatism Associates, Wheaton, Maryland, USA
    Drugs Aging 28:27-40. 2011
    ..Topical NSAIDs reduce systemic NSAID exposure and may mitigate these risks...
  23. ncbi Safety profile of topical diclofenac: a meta-analysis of blinded, randomized, controlled trials in musculoskeletal conditions
    R S Taylor
    Peninsula College of Medicine and Dentistry, Universities of Exeter and Plymouth, Exeter, UK
    Curr Med Res Opin 27:605-22. 2011
    ..Topical non-steroidal anti-inflammatory drugs (NSAIDs) are clinically proven for the management of musculoskeletal conditions. It is important that prescribers and patients are aware of the safety profile of topical NSAIDs...
  24. ncbi Uptake and biological effects of environmentally relevant concentrations of the nonsteroidal anti-inflammatory pharmaceutical diclofenac in rainbow trout (Oncorhynchus mykiss)
    Alvine C Mehinto
    Hatherly Laboratories, School of Biosciences, University of Ereter, Exeter EX4 4PS, UK
    Environ Sci Technol 44:2176-82. 2010
    b>Diclofenac, a nonsteroidal anti-inflammatory drug, is widely detected in surface waters and can potentially cause deleterious effects in fish...
  25. ncbi Celecoxib versus diclofenac plus omeprazole in high-risk arthritis patients: results of a randomized double-blind trial
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR
    Gastroenterology 127:1038-43. 2004
    ..We studied the ulcer incidence and factors predicting ulcer recurrence in a prospective, double-blinded trial...
  26. ncbi Nonsteroidal anti-inflammatory drug reduces neutrophil and macrophage accumulation but does not improve tendon regeneration
    David Marsolais
    Department of Rehabilitation, Faculty of Medicine, Universite Laval, Quebec, Canada
    Lab Invest 83:991-9. 2003
    ..thought to induce nonspecific damage following an injury, we tested the hypothesis that a 3-day treatment with diclofenac would protect tendons from inflammatory cell injury and would promote healing...
  27. ncbi Anti-inflammatory activity of gel containing novel elastic niosomes entrapped with diclofenac diethylammonium
    A Manosroi
    Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
    Int J Pharm 360:156-63. 2008
    ..was to develop a novel elastic bilayer vesicle entrapped with the non-steroidal anti-inflammatory drug (NSAID), diclofenac diethylammonium (DCFD) for topical use...
  28. ncbi Apparent tolerance of turkey vultures (Cathartes aura) to the non-steroidal anti-inflammatory drug diclofenac
    Barnett A Rattner
    Patuxent Wildlife Research Center, U S Geological Survey, Beltsville Agricultural Research Center East, Building 308, 10300 Baltimore Avenue, Beltsville, Maryland 20705, USA
    Environ Toxicol Chem 27:2341-5. 2008
    The nonsteroidal anti-inflammatory drug diclofenac is extremely toxic to Old World Gyps vultures (median lethal dose -0.1-0.2 mg/kg), evoking visceral gout, renal necrosis, and mortality within a few days of exposure...
  29. ncbi Toxic effects of the non-steroidal anti-inflammatory drug diclofenac. Part II: cytological effects in liver, kidney, gills and intestine of rainbow trout (Oncorhynchus mykiss)
    R Triebskorn
    Steinbeis Transfer Center for Ecotoxicology and Ecophysiology, Blumenstr 13, D 72108 Rottenburg, Germany
    Aquat Toxicol 68:151-66. 2004
    ..mykiss) exposed to five different concentrations (1, 5, 20, 100 and 500 microg/L) of the anti-inflammatory drug diclofenac under laboratory conditions...
  30. ncbi Guidelines for the management of actinic keratoses
    Eggert Stockfleth
    Department of Dermatology, Venerology and Allergology, Charite Campus Mitte, Universität Berlin Charitéplatz 1, 10117 Berlin, Germany
    Eur J Dermatol 16:599-606. 2006
  31. ncbi Water-borne diclofenac affects kidney and gill integrity and selected immune parameters in brown trout (Salmo trutta f. fario)
    Birgit Hoeger
    Environmental Toxicology, University of Konstanz, Konstanz, Germany
    Aquat Toxicol 75:53-64. 2005
    ..The objective of the present study was to investigate effects of the non-steroidal anti-inflammatory drug diclofenac, one of the pharmaceuticals most prevalent in surface waters, on brown trout (Salmo trutta f...
  32. ncbi Ex vivo skin delivery of diclofenac by transcutol containing liposomes and suggested mechanism of vesicle-skin interaction
    Maria Manconi
    Department Farmaco Chimico Tecnologico, University of Cagliari, Cagliari, Italy
    Eur J Pharm Biopharm 78:27-35. 2011
    ..the possible mechanism of vesicle-skin interaction, we investigated transcutol containing PEVs as carriers for diclofenac, in the form of either acid or sodium salt...
  33. ncbi Assessment of diclofenac LC50 reference values in juvenile and embryonic stages of the zebrafish (Danio rerio)
    E Praskova
    Department of Veterinary Public Health and Toxicology, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1 3, 612 42 Brno, Czech Republic
    Pol J Vet Sci 14:545-9. 2011
    The aim of the study was to compare the acute toxicity of diclofenac to juvenile and embryonic stages of the zebrafish (Danio rerio)...
  34. pmc Preventative topical diclofenac treatment differentially decreases tumor burden in male and female Skh-1 mice in a model of UVB-induced cutaneous squamous cell carcinoma
    Erin M Burns
    Department of Pathology, The Ohio State University, Columbus, OH 43210, USA
    Carcinogenesis 34:370-7. 2013
    ..Chronic inflammation has been linked to tumorigenesis, with a key role for the cyclooxygenase-2 (COX-2) enzyme. Diclofenac, a COX-2 inhibitor and non-steroidal anti-inflammatory drug, currently is prescribed to patients as a short-term ..
  35. ncbi Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model
    Sridhar R Chirasani
    Department of Neurology, University Medical Centre of Regensburg, Regensburg, Germany
    Int J Cancer 132:843-53. 2013
    ..Here, we report that diclofenac used at nontoxic concentrations significantly decreased lactate production in murine glioma cells and inhibited ..
  36. ncbi Chronic exposure to diclofenac on two freshwater cladocerans and Japanese medaka
    Jinyoung Lee
    School of Public Health, Seoul National University, Seoul 151 742, Republic of Korea
    Ecotoxicol Environ Saf 74:1216-25. 2011
    Consequences of long-term exposure to diclofenac up to 3 months were evaluated using freshwater crustaceans (Daphnia magna and Moina macrocopa) and a fish (Oryzias latipes). Marked decrease of reproduction was observed at 25 mg/L for D...
  37. ncbi The non-steroidal anti-inflammatory drugs Sulindac sulfide and Diclofenac induce apoptosis and differentiation in human acute myeloid leukemia cells through an AP-1 dependent pathway
    Raminder Singh
    Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine University, Dusseldorf, Germany
    Apoptosis 16:889-901. 2011
    ..AML patient samples and the AML cell lines THP-1 and HL-60 were treated with the NSAIDs Sulindac sulfide and Diclofenac. We analyzed viability, apoptosis, differentiation and addressed the molecular mechanisms involved...
  38. pmc Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury
    B H McCarberg
    Kaiser Permanente Health Care, Chronic Pain Management Program, Escondido, CA, USA
    Int J Clin Pract 64:1546-53. 2010
    ..The anti-inflammatory and analgesic potency of the traditional oral NSAID diclofenac, along with its physicochemical properties, makes it well suited for topical delivery...
  39. ncbi Drug targeting to inflammation: studies on antioxidant surface loaded diclofenac liposomes
    Raju Jukanti
    Nanotechnology and Drug Targeting Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India
    Int J Pharm 414:179-85. 2011
    ..We developed conventional and antioxidant loaded diclofenac (DFS) liposomes (co-enzyme Q10 and ascorbyl palmitate) for i.v...
  40. ncbi Nitrosothiol esters of diclofenac: synthesis and pharmacological characterization as gastrointestinal-sparing prodrugs
    U K Bandarage
    NitroMed, Inc, 12 Oak Park Drive, Bedford, Massachusetts 01730, USA
    J Med Chem 43:4005-16. 2000
    Despite its widespread use, diclofenac has gastrointestinal liabilities common to nonsteroidal antiinflammatory drugs (NSAIDs) that might be reduced by concomitant administration of a gastrointestinal cytoprotectant such as nitric oxide (..
  41. pmc Treatment of osteoarthritis of the knee with a topical diclofenac solution: a randomised controlled, 6-week trial [ISRCTN53366886]
    Philip A Baer
    Malvern Medical Centre, Toronto, Canada
    BMC Musculoskelet Disord 6:44. 2005
    ..The efficacy and safety of a topical diclofenac solution over a 6-week treatment course in symptomatic primary OA of the knee was investigated.
  42. ncbi Duration of treatment with nonsteroidal anti-inflammatory drugs and impact on risk of death and recurrent myocardial infarction in patients with prior myocardial infarction: a nationwide cohort study
    Anne Marie Schjerning Olsen
    Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark
    Circulation 123:2226-35. 2011
    ..We therefore studied the duration of NSAID treatment and cardiovascular risk in a nationwide cohort of patients with prior myocardial infarction (MI)...
  43. ncbi Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis
    S Tsutsumi
    Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Cell Death Differ 11:1009-16. 2004
    ..NSAIDs other than indomethacin (diclofenac, ibuprofen and celecoxib) also induced CHOP...
  44. ncbi Equivalence study of a topical diclofenac solution (pennsaid) compared with oral diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial
    Peter S Tugwell
    Centre for Global Health, Institute of Population Health, Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Rheumatol 31:2002-12. 2004
    To compare the safety and efficacy of a topical diclofenac solution versus oral diclofenac in relieving the symptoms of primary osteoarthritis (OA) of the knee, in a randomized, double-blind, double-dummy equivalence trial.
  45. ncbi Efficacy and safety of a topical diclofenac solution (pennsaid) in the treatment of primary osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled clinical trial
    Sanford H Roth
    Arizona Research and Education, Phoenix, USA
    Arch Intern Med 164:2017-23. 2004
    ..A topical NSAID formulation may provide symptom relief with fewer adverse effects. A new topical diclofenac sodium solution-containing the absorption enhancer dimethyl sulfoxide-was evaluated for the relief of the ..
  46. pmc Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial
    Arthur A M Bookman
    Dimethaid Health Care Ltd, 1405 Denison Street, Markham, Ontario L3R 5V2, Canada
    CMAJ 171:333-8. 2004
    ..The objective of this trial was to assess the safety and efficacy of a topical diclofenac solution in relieving the symptoms of primary osteoarthritis of the knee.
  47. ncbi Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo
    John I Johnsen
    Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 64:7210-5. 2004
    ..Treatment of established neuroblastoma xenografts in nude rats with the dual COX-1/COX-2 inhibitor diclofenac or the COX-2-specific inhibitor celecoxib significantly inhibited tumor growth in vivo (P < 0.001)...
  48. ncbi New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, Transfersomes
    G Cevc
    Medizinische Biophsik, Technische Universität Müchen, Munich, Germany
    Biochim Biophys Acta 1514:191-205. 2001
    Transfenac, a lotion-like formulation of diclofenac, is described. It consists of pharmaceutically acceptable ingredients and mediates the agent transport through intact skin and into the target tissues...
  49. ncbi Preparation, characterization and permeation studies of a nanovesicular system containing diclofenac for transdermal delivery
    Praveen Kumar Gaur
    Department of Pharmaceutics, Jodhpur National University, Jodhpur, Rajasthan, India
    Pharm Dev Technol 19:48-54. 2014
    ..Transdermal formulations contain permeation enhancer which causes skin damage. Ceramide 2 is natural lipid found in stratum corneum (SC)...
  50. ncbi Effect of topical application of diclofenac liposomal suspension on experimentally induced subcutaneous inflammation in horses
    Fred J Caldwell
    Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Am J Vet Res 65:271-6. 2004
    To determine whether 1% diclofenac liposomal suspension (DLS) ointment would be absorbed transdermally and attenuate experimentally induced subcutaneous inflammation in horses.
  51. ncbi Development of iron/ethylcellulose (core/shell) nanoparticles loaded with diclofenac sodium for arthritis treatment
    Jose L Arias
    Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy University of Granada, 18071 Granada, Spain
    Int J Pharm 382:270-6. 2009
    b>Diclofenac sodium is a non-steroidal anti-inflammatory drug of choice to treat arthritis because of its potential anti-inflammatory and analgesic activity...
  52. ncbi Hydroxypropylmethylcellulose films for the ophthalmic delivery of diclofenac sodium
    Salah El-Sousi
    Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Al Azhar University, Gaza, Palestine
    J Pharm Pharmacol 65:193-200. 2013
    The aim of this study was to prepare diclofenac/hydroxypropylmethylcellulose (HPMC) and diclofenac-loaded nanoparticles/HPMC films as potential systems for ocular delivery.
  53. ncbi Transdermal drug delivery using microemulsion and aqueous systems: influence of skin storage conditions on the in vitro permeability of diclofenac from aqueous vehicle systems
    Amnon C Sintov
    Department of Pharmacology and School of Pharmacy, Ben Gurion University of the Negev, P O Box 653, Beer Sheva 84105, Israel
    Int J Pharm 311:55-62. 2006
    The objective of this study was to evaluate the transdermal delivery potential of diclofenac-containing microemulsion system in vivo and in vitro...
  54. ncbi Short-term tests with a pilot sewage plant and biofilm reactors for the biological degradation of the pharmaceutical compounds clofibric acid, ibuprofen, and diclofenac
    C Zwiener
    Engler Bunte Institut, Water Chemistry, Universitat Karlsruhe TH, Engler Bunte Ring 1, D 76131 Karlsruhe, Germany
    Sci Total Environ 309:201-11. 2003
    The biodegradation of three active compounds of pharmaceuticals clofibric acid, ibuprofen, and diclofenac was investigated in short-term tests with a pilot sewage plant (PSP) and biofilm reactors (BFR, oxic and anoxic) as model systems ..
  55. ncbi The effects of diclofenac on early life stages of common carp (Cyprinus carpio)
    Stanislava Stěpánová
    University of Veterinary and Pharmaceutical Sciences, Palackeho 1 3, 612 42 Brno, Czech Republic
    Environ Toxicol Pharmacol 35:454-60. 2013
    b>Diclofenac residues have been found in surface water, and thus could present a potential risk to aquatic species...
  56. pmc Effects of dexamethasone, diclofenac, or placebo on the inflammatory response after cataract surgery
    C G Laurell
    Karolinska Institute, St Erik s Eye Hospital, Stockholm, Sweden
    Br J Ophthalmol 86:1380-4. 2002
    To compare the inflammatory response after phacoemulsification and intraocular lens (IOL) implantation using postoperative treatment with dexamethasone, diclofenac, or placebo.
  57. ncbi Markers of mitochondrial dysfunction during the diclofenac-induced apoptosis in melanoma cell lines
    Francesco Albano
    Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, Via S Pansini 5, 80131 Napoli, Italy
    Biochimie 95:934-45. 2013
    ..In particular, diclofenac, one of the most common NSAIDs, displays its anti-proliferative effect in many tumor lines, through an ..
  58. ncbi A randomized, open-label, comparative, 6-month trial of oral ultra-low doses of antibodies to tumor necrosis factor-alpha and diclofenac in rheumatoid arthritis
    J L Dugina
    Materia Medica Holding Research and Production Company, Moscow, Russian Federation
    Int J Tissue React 27:15-21. 2005
    ..The aim of this study was to assess clinical efficacy and safety of artrofoon in RA compared with diclofenac. In a 6-month, randomized, open-label, comparative trial, 60 patients with active RA (eight men and 52 women ..
  59. pmc Effect of microenvironment pH of swellable and erodable buffered matrices on the release characteristics of diclofenac sodium
    Bashar M Al-Taani
    Jordan University of Science and Technology, Faculty of Pharmacy, Department of Pharmaceutical Technology, Irbid, Jordan
    AAPS PharmSciTech 4:E43. 2003
    ..and erodable-buffered matrices and to study the effect of the microenvironment pH on the release pattern of diclofenac sodium...
  60. ncbi Removal of diclofenac potassium from wastewater using clay-micelle complex
    Rafik Karaman
    Faculty of Pharmacy, Al Quds University, Jerusalem, Palestine
    Environ Technol 33:1279-87. 2012
    The presence of an ionized carboxyl group in the widely used non-steroidal anti-inflammatory (NSAID) drug diclofenac potassium results in a high mobility of diclofenac and in its low sorption under conditions of slow sand filtration or ..
  61. ncbi Optimization and evaluation of thermoresponsive diclofenac sodium ophthalmic in situ gels
    Rathapon Asasutjarit
    Department of Pharmaceutical Technology, Faculty of Pharmacy, Srinakharinwirot University, 63 Rangsit Nakhonnayok Road, Nakhonnayok 26120, Thailand
    Int J Pharm 411:128-35. 2011
    This work was conducted to optimize and evaluate Pluronic F127-based thermoresponsive diclofenac sodium ophthalmic in situ gels (DS in situ gel). They were prepared by cold method and investigated their physicochemical properties i.e...
  62. ncbi Comfrey extract ointment in comparison to diclofenac gel in the treatment of acute unilateral ankle sprains (distortions)
    Roberto D'Anchise
    Istituto Ortopedico Galeazzi, Milano, Italy
    Arzneimittelforschung 57:712-6. 2007
    A previously published study comparing the efficacy of comfrey extract to a commercial diclofenac (CAS 78213-16-8) preparation in the treatment of unilateral ankle sprains is critically re-evaluated...
  63. ncbi Combination of diclofenac plus somatostatin in the prevention of post-ERCP pancreatitis: a randomized, double-blind, placebo-controlled trial
    P Katsinelos
    Department of Endoscopy and Motility Unit, G Gennimatas General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Endoscopy 44:53-9. 2012
    ..The aim was to investigate the impact of combined therapy with diclofenac plus somatostatin on reducing the frequency and severity of post-ERCP pancreatitis (PEP).
  64. ncbi Sustained-release diclofenac potassium-loaded solid lipid microparticle based on solidified reverse micellar solution: in vitro and in vivo evaluation
    Salome Amarachi Chime
    Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka 410001, Nigeria
    J Microencapsul 30:335-45. 2013
    To formulate sustained-release diclofenac potassium-loaded solid lipid microparticles (SLMs) based on solidified reverse micellar solution (SRMS) and to evaluate the in vitro and in vivo properties.
  65. ncbi Uptake from water, biotransformation, and biliary excretion of pharmaceuticals by rainbow trout
    Marja Lahti
    Division of Environmental Science and Technology, University of Jyvaskyla, Jyvaskyla, Finland
    Environ Toxicol Chem 30:1403-11. 2011
    ..Rainbow trout were exposed for 10 d under flow-through conditions to mixtures of five pharmaceuticals (diclofenac, naproxen, ibuprofen, bisoprolol, and carbamazepine) at high and low concentrations...
  66. ncbi Effect of sodium chloride on the release, absorption and safety of diclofenac sodium delivered by poloxamer gel
    Young Joon Park
    College of Pharmacy, Seoul National University, San 56 1, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Int J Pharm 263:105-11. 2003
    ..For the development of a thermosensitive diclofenac sodium-loaded poloxamer gel, here we investigated the effect of sodium chloride on the release, safety and ..
  67. pmc Role of intestinal cytochrome p450 enzymes in diclofenac-induced toxicity in the small intestine
    Yi Zhu
    Wadsworth Center, New York State Department of Health, Empire State Plaza, Box 509, Albany, NY 12201 0509, USA
    J Pharmacol Exp Ther 343:362-70. 2012
    ..was to determine the role of small intestinal (SI) cytochrome P450 (P450) enzymes in the metabolic activation of diclofenac (DCF), a widely used nonsteroidal anti-inflammatory drug, and DCF-induced intestinal toxicity...
  68. ncbi Treatment options for actinic keratoses
    William J McIntyre
    University of Arkansas for Medical Sciences Area Health Education Center Southwest, Texarkana 71854, USA
    Am Fam Physician 76:667-71. 2007
    ..Fluorouracil has been the traditional topical treatment for actinic keratoses, although imiquimod 5% cream and diclofenac 3% gel are effective alternative therapies...
  69. ncbi Results of a randomized, placebo-controlled safety and efficacy study of topical diclofenac 3% gel in organ transplant patients with multiple actinic keratoses
    Claas Ulrich
    Skin Cancer Centre Charité, Department of Dermatology, Charite Universitatsmedizin, Charite Platz 1, 10117 Berlin, Germany
    Eur J Dermatol 20:482-8. 2010
    ..Effective management of actinic keratoses (AK) could help to prevent the further development of invasive SCC. Diclofenac in hyaluronic acid has previously shown to be an effective and well tolerated option for the treatment of AK in ..
  70. pmc Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells
    Terry W Moody
    National Cancer Institute, Office of the Director, Center for Cancer Research, Bethesda, MD 20892 1500, USA
    Lung Cancer 68:154-60. 2010
    The effects of dithiolethione modified valproate, diclofenac and sulindac on non-small cell lung cancer (NSCLC) cells were investigated...
  71. ncbi ssDNA aptamers that recognize diclofenac and 2-anilinophenylacetic acid
    Choon Bok Joeng
    College of Life Sciences and Biotechnology, Korea University, Anam Dong, Seongbuk gu, Seoul 136 701, South Korea
    Bioorg Med Chem 17:5380-7. 2009
    A series of 56 ssDNA aptamer variants that bind to diclofenac (DCF) were selected from an initial pool of 2.4x10(14) ssDNA molecules by Flu-Mag SELEX process...
  72. ncbi Geranylgeranylacetone protects against diclofenac-induced gastric and small intestinal mucosal injuries in healthy subjects: a prospective randomized placebo-controlled double-blind cross-over study
    Yasumasa Niwa
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Digestion 80:260-6. 2009
    ..We planned a pilot study to investigate the protective effects of geranylgeranylacetone (GGA) against NSAID-induced small intestinal injuries using video capsule endoscopy (VCE)...
  73. ncbi Alginate/chitosan particulate systems for sodium diclofenac release
    M L González-Rodríguez
    Departamento de Farmacia y Tecnología Farmacacéutica, Facultad de Farmacia, C Profesor Garcia Gonzalez s n, Universidad de Sevilla, 41012, Sevilla, Spain
    Int J Pharm 232:225-34. 2002
    Alginate/chitosan particles were prepared by ionic gelation (Ca2+ and Al3+) for the sodium diclofenac release. The systems were characterized by electron microscopy and differential scanning calorimetry...
  74. ncbi Efficacy of topical diclofenac diethylamine gel in osteoarthritis of the knee
    Fritz U Niethard
    Orthopaedic Clinic, Universitatsklinikum Aachen, Germany
    J Rheumatol 32:2384-92. 2005
    To assess the efficacy and safety of topical diclofenac diethylamine gel, 1.16%, 4 g applied qid for 3 weeks to relieve the symptoms of osteoarthritis (OA) of the knee.
  75. ncbi Tolerability of topical diclofenac sodium 1% gel for osteoarthritis in seniors and patients with comorbidities
    Herbert S B Baraf
    Center for Rheumatology and Bone Research, a division of Arthritis and Rheumatism Associates, PC, Wheaton, Maryland, USA
    Am J Geriatr Pharmacother 10:47-60. 2012
    ..Topical NSAIDs produce lower systemic NSAID exposure compared with oral NSAIDs, offering potential benefits...
  76. ncbi Diclofenac attenuates the regional effect of lambda-carrageenan on blood-brain barrier function and cytoarchitecture
    Tracy A Brooks
    Departments of Pharmacology and Toxicology, University of Arizona Colleges of Pharmacy, Tucson, Arizona, USA
    J Pharmacol Exp Ther 325:665-73. 2008
    ..It describes the role of cyclooxygenase (COX) up-regulation by blocking with diclofenac (30 mg/kg, i.p.), and it examines the variation in BBB regulation through various brain regions...
  77. pmc Effectiveness of diclofenac versus acetaminophen in primary care patients with knee osteoarthritis: [NTR1485], DIPA-trial: design of a randomized clinical trial
    Saskia P J Verkleij
    Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Netherlands
    BMC Musculoskelet Disord 11:7. 2010
    ..drugs, we present the design of a randomized open-label trial to investigate the efficacy of a non-steroidal anti-inflammatory drug (diclofenac) compared with acetaminophen in new consulters with knee osteoarthritis in general practice.
  78. ncbi Efficacy and safety of four doses of lumiracoxib versus diclofenac in patients with knee or hip primary osteoarthritis: a phase II, four-week, multicenter, randomized, double-blind, placebo-controlled trial
    Thomas J Schnitzer
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Arthritis Rheum 51:549-57. 2004
    To compare the efficacy and tolerability of the novel cyclooxygenase 2-selective inhibitor lumiracoxib with placebo and diclofenac in osteoarthritis (OA).
  79. ncbi The anti-inflammatory drug Diclofenac retains anti-listerial activity in vivo
    N K Dutta
    College of Veterinary Medicine and KRF Zoonotic Disease Priority Research Institute, Seoul National University, Seoul, Korea
    Lett Appl Microbiol 47:106-11. 2008
    ..The aim of this study was to investigate the possible effects of Diclofenac (Dc) in a murine listerial infection model.
  80. ncbi Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat
    John L Wallace
    Inflammation Research Network, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada
    Gastroenterology 132:261-71. 2007
    ..In this study, we evaluated the gastrointestinal safety and anti-inflammatory effects of a novel "HS-NSAID" (ATB-337) that consists of diclofenac linked to a hydrogen sulfide-releasing moiety.
  81. ncbi Carbamazepine and diclofenac: removal in wastewater treatment plants and occurrence in water bodies
    Yongjun Zhang
    Department of Environmental Process Engineering, Institute of Environmental Technology, Technical University of Berlin, Strasse des 17 Juni 135, Berlin 10623, Germany
    Chemosphere 73:1151-61. 2008
    In the aquatic environment, pharmaceuticals have been widely found. Among them, carbamazepine and diclofenac were detected at the highest frequency...
  82. pmc Diclofenac induces basophil degranulation without increasing CD63 expression in sensitive patients
    A Malbran
    Unidad de Alergia, Asma e Inmunología Clínica, Repulblica Argentina
    Clin Exp Immunol 147:99-105. 2007
    b>Diclofenac (Dc) induces an IgE-independent basophil (Ba) degranulation in susceptible individuals. CD63 Ba expression is utilized as an in vitro test for diagnosis of drug hypersensitivity...
  83. ncbi Electrospun diclofenac sodium loaded Eudragit® L 100-55 nanofibers for colon-targeted drug delivery
    Xiaxia Shen
    College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China
    Int J Pharm 408:200-7. 2011
    Eudragit® L 100-55 nanofibers loaded with diclofenac sodium (DS) were successfully prepared using an electrospinning process, and characterized for structural and pharmacodynamic properties...
  84. ncbi The role of CYP2C9 genotype in the metabolism of diclofenac in vivo and in vitro
    U Yasar
    Department of Medical Laboratory Sciences and Technology, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden
    Eur J Clin Pharmacol 57:729-35. 2001
    ..b>Diclofenac is metabolised to 4'-hydroxy (OH), the major diclofenac metabolite, 3'-OH and 3'-OH-4'-methoxy metabolites by ..
  85. ncbi Liposomal dexamethasone-diclofenac combinations for local osteoarthritis treatment
    Inbar Elron-Gross
    Department of Biochemistry, Tel Aviv University, Tel Aviv, Israel
    Int J Pharm 376:84-91. 2009
    Conventional chronic and acute treatments for osteoarthritis (OA) are by oral NSAIDs (such as diclofenac) and intra-articular injected glucocorticosteroids (such as dexamethasone)...
  86. ncbi Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio)
    R Triebskorn
    Steinbeis Transfer Center for Ecotoxicology and Ecophysiology, Blumenstr 13, 72108 Rottenburg, Germany
    Anal Bioanal Chem 387:1405-16. 2007
    ..in aquatic wildlife, laboratory experiments were conducted with carbamazepine, clofibric acid, metoprolol, and diclofenac using fish as test organisms. For each substance, at least one environmentally relevant concentration was tested...
  87. ncbi Safety of intravitreal ketorolac and diclofenac: an electroretinographic and histopathologic study
    Stephen J Kim
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Retina 28:595-605. 2008
    To determine the clinical, histologic, and electroretinographic effects in the rabbit retina of escalating doses of two intravitreally delivered nonsteroidal anti-inflammatory drugs (NSAIDs): ketorolac and diclofenac.
  88. ncbi Characterization of the influence of polyol fatty acid esters on the permeation of diclofenac through rat skin
    K Takahashi
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya, 663 8179, Hyogo, Japan
    J Control Release 73:351-8. 2001
    ..Removal of the stratum corneum and delipidization of the skin increased the permeation of diclofenac from aqueous suspension, with the enhancement effects being similar for both treatments...
  89. ncbi Diclofenac, a nonsteroidal anti-inflammatory drug, activates the transient outward K+ current in rat cerebellar granule cells
    Lin Yun Liu
    Center for Brain Science Research, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200433, PR China
    Neuropharmacology 48:918-26. 2005
    b>Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), has been widely investigated in terms of its pharmacological action, but less is known about its direct effect on ion channels...
  90. ncbi Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: the DOLOR study
    M A Mibielli
    Centro Universitário Serra dos Orgãos UNIFESO, Rio de Janeiro, Brazil
    Curr Med Res Opin 25:2589-99. 2009
    To assess the influence of vitamins B1, B6 and B12 on the analgesia success achieved by diclofenac in subjects with acute lumbago.
  91. ncbi Modes of action of diclofenac 3%/hyaluronic acid 2.5% in the treatment of actinic keratosis
    Adrienne Maltusch
    Skin Cancer Center, Charite Universitatsmedizin Berlin, Germany
    J Dtsch Dermatol Ges 9:1011-7. 2011
    The efficacy of topically applied diclofenac 3 % in combination with hyaluronic acid 2.5 % in the treatment of actinic keratoses (AKs) has been demonstrated in several clinical studies, but the exact mode of action is still unclear...
  92. ncbi In vitro and in vivo evaluation of polyoxyethylene esters as dermal prodrugs of ketoprofen, naproxen and diclofenac
    F P Bonina
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Eur J Pharm Sci 14:123-34. 2001
    Novel polyoxyethylene esters of ketoprofen (1(a-e)), naproxen (2(a-e)) and diclofenac (3(a-e)) were synthesized and evaluated as potential dermal prodrugs of naproxen, ketoprofen and diclofenac...
  93. ncbi Oral bioavailability, efficacy and gastric tolerability of P2026, a novel nitric oxide-releasing diclofenac in rat
    Asif R Pathan
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Inflammopharmacology 18:157-68. 2010
    ..2-(2-(2,6-dichlorophenylamino)phenyl)acetate)], a novel NO (nitric oxide) donor prodrug of diclofenac for its ability to release NO and diclofenac, and whether P2026 provides advantage of improved activity/gastric ..
  94. ncbi Diclofenac attenuates Wnt/beta-catenin signaling in colon cancer cells by activation of NF-kappaB
    Munju Cho
    PharmcoGenomic Research Center, Inje University, Busan 633 165, Republic of Korea
    FEBS Lett 579:4213-8. 2005
    ..We show that the NSAID diclofenac inhibits Wnt/beta-catenin signaling without altering the level of beta-catenin protein and reduces the ..
  95. ncbi Postoperative nefopam and diclofenac. Evaluation of their morphine-sparing effect after upper abdominal surgery
    A C Moffat
    Division of Anaesthesia, Law Hospital, Carluke, Lanarkshire
    Anaesthesia 45:302-5. 1990
    The aim of the study was to assess the relative morphine-sparing effects of nefopam and diclofenac when used singly or in combination after upper abdominal surgery...
  96. ncbi Drug-drug interaction between diclofenac, cetirizine and ranitidine
    Ihsan M Kenawi
    Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
    J Pharm Biomed Anal 37:655-61. 2005
    The interactions between diclofenac (1), cetirizine (2) and ranitidine (3) were investigated by thermal analyses and UV, IR and (1)H NMR spectroscopic studies...
  97. ncbi Nocturnal enuresis: correction of renal function by desmopressin and diclofenac
    Y V Natochin
    J M Sechenov Institut of Evolutionary Physiology and Biochemistry, St Petersburg, Russia
    Pediatr Nephrol 14:42-7. 2000
    ..43 boys, 19 girls aged 6-15 years) were treated with either desmopressin (Adiuretin-SD) (n = 32) or sodium diclofenac (n = 30). Desmopressin was effective in 85% of children and diclofenac in 33%...
  98. ncbi SKI306X, an oriental herbal mixture, suppresses gastric leukotriene B4 synthesis without causing mucosal injury and the diclofenac-induced gastric lesions
    Joo Hyon Kim
    Life Science Research Center, SK Chemicals, 600 Jungja 1 Dong, Changan Ku, Suwon Si, Kyungki Do 440 745, Korea
    Life Sci 77:1181-93. 2005
    ..study, SKI306X was investigated for its gastro-sparing effects on the gastric mucosa comparing with those of diclofenac, a conventional NSAID, and celecoxib, a cyclooxygenase-2 (COX-2) specific inhibitor...
  99. pmc Diclofenac inhibits tumor growth in a murine model of pancreatic cancer by modulation of VEGF levels and arginase activity
    Nina Mayorek
    Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 5:e12715. 2010
    b>Diclofenac is one of the oldest anti-inflammatory drugs in use. In addition to its inhibition of cyclooxygenases (COX), diclofenac potently inhibits phospholipase A(2) (PLA(2)), thus yielding a broad anti-inflammatory effect...
  100. ncbi Rebamipide has the potential to reduce the intensity of NSAID-induced small intestinal injury: a double-blind, randomized, controlled trial evaluated by capsule endoscopy
    Shunji Fujimori
    Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8603, Japan
    J Gastroenterol 46:57-64. 2011
    ..The purpose of this study was to re-evaluate the effect of the co-administration of rebamipide on small intestinal injuries induced by short-term NSAID treatment...
  101. ncbi Development of pH-sensitive tamarind seed polysaccharide-alginate composite beads for controlled diclofenac sodium delivery using response surface methodology
    Amit Kumar Nayak
    Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj, Orissa, India
    Int J Biol Macromol 49:784-93. 2011
    ..the development of novel pH-sensitive tamarind seed polysaccharide (TSP)-alginate composite beads for controlled diclofenac sodium delivery using response surface methodology by full 3(2) factorial design...

Research Grants24

  1. Topical Nanoparticles for CNV
    Uday B Kompella; Fiscal Year: 2010
    ..the feasibility of using a nanoparticle technology of NanoTrans for topical administration of a model drug diclofenac, for the management of choroidal neovascularization...
  2. Aldo-keto reductase family 1 member B10 AKR1B10 in pancreatic carcinogenesis
    Guang Yu Yang; Fiscal Year: 2013
    ..3) Diclofenac and Sulindac [non- steroidal anti-inflammatory drugs (NSAIDs)] are competitive inhibitors of AKR1B10...
  3. Chemo-enzymatic Approach to Late-stage Aromatic Fluorination of Drug Scaffolds
    RYAN MARK LAUCHLI; Fiscal Year: 2012
    ..of the aryl fluoride, and 3) to expand the strategy developed in aims 1 and 2 to the drugs warfarin and diclofenac. Using directed evolution, cytochrome P450 BM3 will be developed to carry out aromatic hydroxylation not only in ..
  4. Pharmaceutical polymorphs: an electronic approach
    Mikhail Yu Antipin; Fiscal Year: 2010
    ..We plan to grow polymorphs of five known pharmaceutical/bioactive compounds: acetaminophen, phenobarbital, diclofenac acid, glycine and thalidomide...
  5. Bioequivalence of topical drug products: in vitro - in vivo correlations
    Audra L Stinchcomb; Fiscal Year: 2013
    ..aims: [A] An initial, intensive, 12-month program of work focused on econazole, betamethasone valerate (BMV) and diclofenac. For the anti-fungal and BMV, to generate in vitro skin penetration and release test data for comparison and ..
  6. Early Events in Diclofenac Enteropathy
    MARY MOSLEN; Fiscal Year: 2004
    ..will critically test our new hypothesis that drug-protein adducts are causal factors in the pathogenesis of diclofenac-induced ulcers in the small intestine...
  7. BIODEGRADABLE DELIVERY SYSTEM FOR NSAIDS
    ARTHUR TIPTON; Fiscal Year: 1990
    ..Five NSAIDs will be individually evaluated in the release system: naproxen, diclofenac, piroxicam, sulindac and flurbiprofen...
  8. ACYLCOA FORMATION--COVALENT BINDING, PHARMACOKINETICS
    Leslie Benet; Fiscal Year: 2002
    ..derivatives in vivo and in vitro, 7) To identify the hepatic protein targets for reactive metabolites of diclofenac, resulting from either glucuronide or CoA-thioester intermediates, using 2D-PAGE and mass spectrometry; 8) To ..
  9. Novel ophthalmic drug delivery vehicles
    HANS HOFLAND; Fiscal Year: 2002
    ..b>Diclofenac is the drug model which is being used to develop this platform, but the platform will be able to accommodate any ..
  10. Clinical Studies with Phospholipid-Associated NSAIDs
    Lenard Lichtenberger; Fiscal Year: 2004
    ..biological activity of a formulation of aspirin (ASA) and another non-steroidal anti-inflammatory drug (NSAID), diclofenac, chemically associated with the zwitterionic phospholipid, phosphatidylcholine (PC)...
  11. Selective inhibition of COX-2 by lumiracoxib
    ANNA BLOBAUM; Fiscal Year: 2007
    ..Lumiracoxib, a structural analog of diclofenac, is 500-fold more selective for COX-2 than COX-1. Currently, the basis for this selectivity remains unclear...
  12. Reducing Renal TGF-B in Diabetic Glomerulosclerosis
    MARGO COHEN; Fiscal Year: 2005
    ..abstract_text> ..
  13. LDL Modification in Diabetic Complications
    MARGO COHEN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  14. Point-of-Care Measurement of Glycated Hemoglobin
    MARGO COHEN; Fiscal Year: 2004
    ....
  15. Health Promotion Intervention:Sedentary Care Patients
    Kerry Kuehl; Fiscal Year: 2008
    ..Outcomes will be assessed using repeated measures design. Relationships among mediators, the intervention, and the outcome measures will be identified. ..
  16. Novel Imaging to Predict Cardiovascular Events in Diabetes
    Zahi A Fayad; Fiscal Year: 2010
    ..It is our expectation that our data will be utilized to evaluate and improve existent treatment and develop effective new therapies to decrease the burden of atherosclerotic disease in diabetes. ..
  17. CYCLOOXYGENASE/NUCLEOBINDIN INTERACTION
    DANIEL SIMMONS; Fiscal Year: 2001
    ..Additionally, a new variant of Nuc expressed in fibroblasts that lacks 33 amino acids in its COX binding domain will be examined. ..
  18. MOLECULAR MECHANISMS OF EIAV PERSISTENCE
    JERALD OAKS; Fiscal Year: 2001
    ..These studies will provide insight into HIV persistence in HAART patients, and potentially provide a model that can be used to evaluate strategies for actual elimination of lentiviral infections. ..
  19. Dermatomyositis Skin Disease Severity Measure Validation
    JOSPEH JORIZZO; Fiscal Year: 2003
    ..abstract_text> ..
  20. STUDY OF OSTEOPOROTIC FRACTURES
    Marc Hochberg; Fiscal Year: 2005
    ....
  21. THERAPY FOR GASTROINTESTINAL DISORDERS
    Elizabeth Dial; Fiscal Year: 2002
    ..Development of this therapeutic potential for rhLF will fulfill a crucial need for a way to safely administer NSAIDs. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  22. SYNERGISM AND MEDICATIONS DEVELOPMENT FOR DRUG ABUSE
    Ronald Tallarida; Fiscal Year: 2004
    ..This guide is the newest aim of this revised application. ..
  23. Role of T Cells in Lung Disease in Systemic Sclerosis
    Marc Hochberg; Fiscal Year: 2006
    ..The new information that is gained will advance knowledge of T-cell dependent mechanisms of pulmonary fibrosis in scleroderma. ..
  24. Assessment of Infant Outcomes After in Utero Exposure to Antiretroviral Therapy
    Sonia Hernandez diaz; Fiscal Year: 2010
    ..We propose to evaluate the risk of congenital malformations and other adverse pregnancy outcomes following antenatal exposure to ART in a prospective cohort of pregnant women. ..