benzoates

Summary

Summary: Salts and esters of BENZOIC ACID that possess antibacterial and antifungal properties. They are used as preservatives in pharmaceuticals, cosmetics, and foods.

Top Publications

  1. ncbi Effects of antihypertensive treatment with angiotensin II receptor blockers on lipid profile: an open multi-drug comparison trial
    Stella Maria G Kyvelou
    Hypertension Unit, 1st Cardiology Department, Athens University, Hippokration Hospital, Greece
    Hellenic J Cardiol 47:21-8. 2006
  2. ncbi Telmisartan, ramipril, or both in patients at high risk for vascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 358:1547-59. 2008
  3. ncbi Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression
    Jiu Chang Zhong
    Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Vascular Biology, Shanghai Institute of Hypertension, Shanghai 200025, China
    Regul Pept 166:90-7. 2011
  4. ncbi Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity
    Stephen C Benson
    Department of Biological Sciences, California State University, Hayward, USA
    Hypertension 43:993-1002. 2004
  5. ncbi Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity
    Michael Schupp
    Center for Cardiovascular Research, Institut fur Pharmakologie und Toxikologie, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Circulation 109:2054-7. 2004
  6. ncbi Deferasirox reduces iron overload significantly in nontransfusion-dependent thalassemia: 1-year results from a prospective, randomized, double-blind, placebo-controlled study
    Ali T Taher
    American University of Beirut, Beirut, Lebanon
    Blood 120:970-7. 2012
  7. ncbi Low dose of telmisartan prevents ischemic brain damage with peroxisome proliferator-activated receptor-gamma activation in diabetic mice
    Jun Iwanami
    Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan
    J Hypertens 28:1730-7. 2010
  8. pmc Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
    Johannes Peter Stasch
    Institute of Cardiovascular Research, Bayer HealthCare, Wuppertal, Germany
    J Clin Invest 116:2552-61. 2006
  9. ncbi Treating the metabolic syndrome: telmisartan as a peroxisome proliferator-activated receptor-gamma activator
    T W Kurtz
    Laboratory of Medicine, University of California San Francisco, 185 Berry Street, Suite 290, San Francisco, CA 94107, USA
    Acta Diabetol 42:S9-16. 2005
  10. pmc Role of the retinoic acid receptor-α in HIV-associated nephropathy
    Krishna K Ratnam
    Division of Nephrology, Mount Sinai School of Medicine, New York, New York, USA
    Kidney Int 79:624-34. 2011

Research Grants

  1. ASTATINE AND IODINE RADIOLABELED MONOCLONAL ANTIBODIES
    Michael Rod Zalutsky; Fiscal Year: 2013
  2. BXR SIGNALING IN VERTEBRATE DEVELOPMENT
    Bruce Blumberg; Fiscal Year: 2004
  3. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
  4. Adrenergic Antagonism During Murine Candidiasis
    Brad Spellberg; Fiscal Year: 2008
  5. Modulation of Iron Deposition in SCD and Other Hemoglobinopathies
    ELLIOTT P contact VICHINSKY; Fiscal Year: 2010
  6. CARDIOPROTECTIVE EFFECT--NEW CHELATORS FOR THALASSEMIA
    Chaim Hershko; Fiscal Year: 2001
  7. E/BETA THALASSEMIA--NATURAL HISTORY & RESPONSE TO CHEMO
    Elliott Vichinsky; Fiscal Year: 2002
  8. Eighth Cooley's Anemia Symposium
    Elliott Vichinsky; Fiscal Year: 2005
  9. Imaging of O6-Alkylguanine-DNA Alkyltransferase
    Ganesan Vaidyanathan; Fiscal Year: 2005
  10. RESIN-BASED REMINERALIZING CEMENTS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2009

Detail Information

Publications284 found, 100 shown here

  1. ncbi Effects of antihypertensive treatment with angiotensin II receptor blockers on lipid profile: an open multi-drug comparison trial
    Stella Maria G Kyvelou
    Hypertension Unit, 1st Cardiology Department, Athens University, Hippokration Hospital, Greece
    Hellenic J Cardiol 47:21-8. 2006
    ..This study was conducted to evaluate blood pressure control and the plasma lipid profile in hypertensive patients after six months' treatment with ARB...
  2. ncbi Telmisartan, ramipril, or both in patients at high risk for vascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 358:1547-59. 2008
    ..We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes...
  3. ncbi Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression
    Jiu Chang Zhong
    Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Vascular Biology, Shanghai Institute of Hypertension, Shanghai 200025, China
    Regul Pept 166:90-7. 2011
    ..In conclusion, telmisartan treatment attenuates vascular hypertrophy in SHR by the modulation of ACE2 and profilin-1 expression with a marked reversal of ERK1/2 and JNK phosphorylation signaling pathways...
  4. ncbi Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity
    Stephen C Benson
    Department of Biological Sciences, California State University, Hayward, USA
    Hypertension 43:993-1002. 2004
    ....
  5. ncbi Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity
    Michael Schupp
    Center for Cardiovascular Research, Institut fur Pharmakologie und Toxikologie, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Circulation 109:2054-7. 2004
    ..The peroxisome proliferator-activated receptor-gamma (PPARgamma) is the central regulator of insulin and glucose metabolism improving insulin sensitivity. We investigated the regulation of PPARgamma function by ARBs...
  6. ncbi Deferasirox reduces iron overload significantly in nontransfusion-dependent thalassemia: 1-year results from a prospective, randomized, double-blind, placebo-controlled study
    Ali T Taher
    American University of Beirut, Beirut, Lebanon
    Blood 120:970-7. 2012
    ..8%), and diarrhea (n = 6; 3.6%). This is the first randomized study showing that iron chelation with deferasirox significantly reduces iron overload in NTDT patients with a frequency of overall adverse events similar to placebo...
  7. ncbi Low dose of telmisartan prevents ischemic brain damage with peroxisome proliferator-activated receptor-gamma activation in diabetic mice
    Jun Iwanami
    Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan
    J Hypertens 28:1730-7. 2010
    ..Telmisartan is a unique AT1 receptor blocker with a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonistic action. Activation of PPAR-gamma could prevent inflammation and brain damage...
  8. pmc Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
    Johannes Peter Stasch
    Institute of Cardiovascular Research, Bayer HealthCare, Wuppertal, Germany
    J Clin Invest 116:2552-61. 2006
    ....
  9. ncbi Treating the metabolic syndrome: telmisartan as a peroxisome proliferator-activated receptor-gamma activator
    T W Kurtz
    Laboratory of Medicine, University of California San Francisco, 185 Berry Street, Suite 290, San Francisco, CA 94107, USA
    Acta Diabetol 42:S9-16. 2005
    ..If the preliminary data are supported by the results of ongoing large-scale clinical studies, telmisartan could have a central role in the prevention and treatment of metabolic syndrome, diabetes and atherosclerosis...
  10. pmc Role of the retinoic acid receptor-α in HIV-associated nephropathy
    Krishna K Ratnam
    Division of Nephrology, Mount Sinai School of Medicine, New York, New York, USA
    Kidney Int 79:624-34. 2011
    ..Thus, a defect in the endogenous synthesis of retinoic acid contributes to loss of the protection by retinoic acid in HIVAN. Hence, RARα agonists may be potential agents for the treatment of HIVAN...
  11. ncbi Telmisartan: a different angiotensin II receptor blocker protecting a different population?
    M Burnier
    Division of Nephrology and Hypertension Consultation, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Int Med Res 37:1662-79. 2009
    ..A class effect for ARBs cannot be assumed. To date, telmisartan is the only ARB that has been shown to reduce cardiovascular risk in at-risk cardiovascular patients...
  12. ncbi Blood pressure control by the nifedipine GITS-telmisartan combination in patients at high cardiovascular risk: the TALENT study
    Giuseppe Mancia
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Italy
    J Hypertens 29:600-9. 2011
    ..Because of the complementary mechanism of action and the evidence of cardiovascular protective effects they include the combination of a calcium antagonist and an angiotensin receptor antagonist among the priorital ones to employ...
  13. ncbi Modulation of PPAR-gamma by telmisartan protects the heart against myocardial infarction in experimental diabetes
    Sameer Goyal
    Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Chem Biol Interact 185:271-80. 2010
    ..In addition to class effects of ARBs, telmisartan reduces oxidative stress and apoptosis and improves cardiac function via the PPAR-gamma pathway...
  14. pmc Prevention and intervention studies with telmisartan, ramipril and their combination in different rat stroke models
    Christa Thoene-Reineke
    Center for Cardiovascular Research Institute of Pharmacology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e23646. 2011
    ....
  15. ncbi Comparative antihypertensive and renoprotective effects of telmisartan and lisinopril after long-term treatment in hypertensive diabetic rats
    W Wienen
    Department of Pharma Research, Boehringer Ingelheim, Pharma KG, Biberach, Germany
    J Renin Angiotensin Aldosterone Syst 2:31-6. 2001
    ..In conclusion, telmisartan, 10 mg/kg/day, is at least as beneficial as lisinopril, 10 mg/kg/day, in lowering BP, reducing cardiac hypertrophy and attenuating renal excretion of protein and albumin in this model...
  16. ncbi Telmisartan inhibits vasoconstriction via PPARγ-dependent expression and activation of endothelial nitric oxide synthase
    Chi Yung Yuen
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Cardiovasc Res 90:122-9. 2011
    ....
  17. ncbi Beneficial role of telmisartan on cardiovascular complications associated with STZ-induced type 2 diabetes in rats
    Bhoomika R Goyal
    Department of Pharmacology, L M College of Pharmacy, Ahmedabad 380 009, Gujarat, India
    Pharmacol Rep 63:956-66. 2011
    ..In conclusion, our data suggest that telmisartan prevented STZ-induced metabolic abnormalities and cardiovascular complications in type 2 diabetes...
  18. ncbi Single-pill combination of telmisartan/amlodipine in patients with severe hypertension: results from the TEAMSTA severe HTN study
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Clin Hypertens (Greenwich) 14:206-15. 2012
    ..T/A SPCs were well tolerated...
  19. ncbi Efficacy and tolerability of initial therapy with single-pill combination telmisartan/hydrochlorothiazide 80/25 mg in patients with grade 2 or 3 hypertension: a multinational, randomized, double-blind, active-controlled trial
    Dingliang L Zhu
    Shanghai Ruijin Hospital, Shanghai Institute of Hypertension, 197 Ruijin 2nd Road, Shanghai, China
    Clin Ther 34:1613-24. 2012
    ..Patients with grade 2 or 3 hypertension may require high-dose combination therapy to achieve blood pressure (BP) targets in a timely manner...
  20. ncbi Combination of amlodipine plus angiotensin receptor blocker or diuretics in high-risk hypertensive patients: a 96-week efficacy and safety study
    Liyuan Ma
    Department of Evidence Based Medicine, Cardiovascular Institute, Beijing, China
    Am J Cardiovasc Drugs 12:137-42. 2012
    ....
  21. ncbi Telmisartan acts through the modulation of ACE-2/ANG 1-7/mas receptor in rats with dilated cardiomyopathy induced by experimental autoimmune myocarditis
    Vijayakumar Sukumaran
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Life Sci 90:289-300. 2012
    ..We investigated the cardioprotective effects of telmisartan in rats with dilated cardiomyopathy [DCM] after experimental autoimmune myocarditis [EAM]...
  22. pmc Telmisartan ameliorates lipopolysaccharide-induced innate immune response through peroxisome proliferator-activated receptor-γ activation in human monocytes
    Tao Pang
    Section on Pharmacology, Division of Intramural Research Programs, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Hypertens 30:87-96. 2012
    ....
  23. ncbi Single-pill combination of telmisartan/amlodipine versus amlodipine monotherapy in diabetic hypertensive patients: an 8-week randomized, parallel-group, double-blind trial
    Arya M Sharma
    Chair for Obesity Research and Management, University of Alberta, Royal Alexandra Hospital, Edmonton, Alberta, Canada
    Clin Ther 34:537-51. 2012
    ..Hypertensive patients with diabetes often require combination therapy to achieve a blood pressure (BP) goal, and evidence suggests that time to BP goal is crucial to decrease cardiovascular risk...
  24. ncbi Telmisartan is a potent target for prevention and treatment in human prostate cancer
    Kiyoaki Funao
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Oncol Rep 20:295-300. 2008
    ..Telmisartan may mediate potent antiproliferative effects against PC cells through PPAR-gamma. Thus, Telmisartan is a potent target for prevention and treatment in PC...
  25. pmc Synthetic retinoid AM80 inhibits Th17 cells and ameliorates experimental autoimmune encephalomyelitis
    Christian Klemann
    Director, Department of Immunology, or Shinji Oki, Ph D, Section Chief, Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    Am J Pathol 174:2234-45. 2009
    ..These findings suggest that retinoid signaling regulates both inflammatory Th17 cells and Th17-like regulatory cells...
  26. ncbi Reduction of proteinuria with angiotensin receptor blockers
    Jan Galle
    Department of Nephrology and Dialysis at Klinikum Lüdenscheid, Ludenscheid, Germany
    Nat Clin Pract Cardiovasc Med 5:S36-43. 2008
    ..These data support the proposition that blockade of the renin-angiotensin system beyond that required for maximum blood pressure reduction provides optimum renal protection...
  27. ncbi Telmisartan-induced inhibition of vascular cell proliferation beyond angiotensin receptor blockade and peroxisome proliferator-activated receptor-gamma activation
    Koichi Yamamoto
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Hypertension 54:1353-9. 2009
    ..It might be postulated that inhibition of AKT activation is a mechanism mediating the antiproliferative effects of telmisartan, including in cells lacking AT1 receptors or PPARgamma...
  28. pmc Deferasirox is a powerful NF-kappaB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging
    Emanuela Messa
    Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin, Regione Gonzole 10, 10043 Orbassano, Torino, Italy
    Haematologica 95:1308-16. 2010
    ..Nuclear factor-kappaB is a key regulator of many cellular processes and its impaired activity has been described in different myeloid malignancies including myelodysplastic syndromes...
  29. pmc NO synthase-generated NO acts downstream of auxin in regulating Fe-deficiency-induced root branching that enhances Fe-deficiency tolerance in tomato plants
    Chong Wei Jin
    College of Environmental and Resource Science, Zhejiang University, Hangzhou 310058, China
    J Exp Bot 62:3875-84. 2011
    ....
  30. ncbi Dual repressive effect of angiotensin II-type 1 receptor blocker telmisartan on angiotensin II-induced and estradiol-induced uterine leiomyoma cell proliferation
    Aki Isobe
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Hum Reprod 23:440-6. 2008
    ..Elevated blood pressure has an independent, positive association with risk for clinically detected uterine leiomyoma. Angiotensin II (Ang II) is a key biological peptide in the renin-angiotensin system that regulates blood pressure...
  31. ncbi Long-term treatment with the AT1-receptor antagonist telmisartan inhibits biglycan accumulation in murine atherosclerosis
    Nadine Nagy
    Institut fur Pharmakologie, Universitatsklinikum Essen, Universitat Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Basic Res Cardiol 105:29-38. 2010
    ..Thus, biglycan is a pleiotropic target of telmisartan that might contribute to the anti-atherogenic effects of this AT1-antagonist...
  32. ncbi Eltrombopag for management of chronic immune thrombocytopenia (RAISE): a 6-month, randomised, phase 3 study
    Gregory Cheng
    Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Lancet 377:393-402. 2011
    ..We aimed to compare the response to once daily eltrombopag versus placebo in patients with chronic immune thrombocytopenia during a 6-month period...
  33. ncbi Nitric oxide-independent stimulation of soluble guanylate cyclase with BAY 41-2272 in cardiovascular disease
    Guido Boerrigter
    Cardiorenal Research Laboratory, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cardiovasc Drug Rev 25:30-45. 2007
    ..Finally, the significance of the novel NO- and heme-independent sGC activator BAY 58-2667, which activates two forms of NO-insensitive sGC, is briefly discussed...
  34. ncbi Antiproliferative activity of paeoniflorin is through cell cycle arrest and the Fas/Fas ligand-mediated apoptotic pathway in human non-small cell lung cancer A549 cells
    Jen Yu Hung
    Division of Pulmonary and Critical Care Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Clin Exp Pharmacol Physiol 35:141-7. 2008
    ..4. This is the first study to show that the induction of p21/WAF1 and the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of PF in A549 cells...
  35. ncbi Iron chelation with deferasirox in adult and pediatric patients with thalassemia major: efficacy and safety during 5 years' follow-up
    M Domenica Cappellini
    Universita di Milano, Ca Granda Foundation Istituto di Ricovero e Cura a Carattere Scientifico corrected IRCCS, Milan, Italy
    Blood 118:884-93. 2011
    ..This trial was registered at www.clinicaltrials.gov as #NCT00171210...
  36. ncbi Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor
    Jay R Thiagarajah
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, 94143, USA
    Gastroenterology 126:511-9. 2004
    ..Here, we characterize the efficacy and pharmacodynamics of CFTR(inh)-172 in blocking cAMP and cGMP induced Cl(-)/fluid secretion in rodent and human intestine...
  37. ncbi Telmisartan suppresses cerebral injury in a murine model of transient focal ischemia
    Yukiko Kasahara
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    Brain Res 1340:70-80. 2010
    ....
  38. ncbi PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin
    Ronald Clasen
    Center for Cardiovascular Research, Institut fur Pharmakologie und Toxikologie, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Hypertension 46:137-43. 2005
    ..ARB-induced adiponectin stimulation is likely to be mediated via PPARgamma activation involving a post-transcriptional mechanism...
  39. pmc ApoE promotes the proteolytic degradation of Abeta
    Qingguang Jiang
    Alzheimer Research Laboratory, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Neuron 58:681-93. 2008
    ..GW3965 treatment also reversed contextual memory deficits. These data demonstrate a mechanism through which ApoE facilitates the clearance of Abeta from the brain and suggest that LXR agonists may represent a novel therapy for AD...
  40. doi Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial
    S Yusuf
    Lancet 372:1174-83. 2008
    ..We therefore assessed whether the angiotensin-receptor blocker telmisartan would be effective in patients intolerant to ACE inhibitors with cardiovascular disease or diabetes with end-organ damage...
  41. ncbi Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib
    John C McKew
    Department of Chemical and Screening Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    J Med Chem 51:3388-413. 2008
    ..Finally, these compounds have shown efficacy when dosed orally in multiple acute and chronic prostaglandin and leukotriene dependent in vivo models...
  42. ncbi AMN082, an allosteric mGluR7 agonist that inhibits afferent glutamatergic transmission in rat basolateral amygdala
    Annarosa Ugolini
    Department of Biology, Neuroscience Centre of Excellence for Drug Discovery, Psychiatry CEDD, GlaxoSmithKline Medicines Research Centre S p A, Via Fleming 4, 37135 Verona, Italy
    Neuropharmacology 55:532-6. 2008
    ..These results suggest that mGLUR7 has a unique role in regulating neuronal activity in the BLA and may be a target for novel drugs for the treatment of anxiety...
  43. ncbi Effect of telmisartan addition to amlodipine on ankle edema development in treating hypertensive patients
    Roberto Fogari
    University of Pavia, Clinica Medica II, Centro Ipertensione e Fisiopatologia Cardiovascolare, Department of Internal Medicine and Therapeutics, Piazzale Golgi 19, 27100 Pavia, Italy
    Expert Opin Pharmacother 12:2441-8. 2011
    ..The objective of this research was to evaluate the effect of telmisartan addition to amlodipine, on peripheral edema in hypertensive patients...
  44. ncbi CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor
    Danieli B Salinas
    Department of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    Am J Physiol Lung Cell Mol Physiol 287:L936-43. 2004
    ..In pigs, CFTR may not be responsible for Cl- channel-dependent nasal PDs. These results have important implications for interpreting nasal PDs in terms of CFTR function in animal models of CFTR activation and inhibition...
  45. pmc Cardioprotective effects of telmisartan against heart failure in rats induced by experimental autoimmune myocarditis through the modulation of angiotensin-converting enzyme-2/angiotensin 1-7/mas receptor axis
    Vijayakumar Sukumaran
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Int J Biol Sci 7:1077-92. 2011
    ....
  46. ncbi Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial
    Johannes F E Mann
    Schwabing General Hospital, and KfH Kidney Centre, Ludwig Maximilians University Munchen, Germany
    Lancet 372:547-53. 2008
    ..We investigated the renal effects of ramipril (an ACE inhibitor), telmisartan (an ARB), and their combination in patients aged 55 years or older with established atherosclerotic vascular disease or with diabetes with end-organ damage...
  47. ncbi Telmisartan/Hydrochlorothiazide: a review of its use as fixed-dose combinations in essential hypertension
    Greg L Plosker
    Wolters Kluwer Health Adis, Auckland, New Zealand
    Drugs 68:1877-99. 2008
    ..As such, fixed-dose combinations of telmisartan/HCTZ provide an effective, rational and generally well tolerated treatment option for the management of patients with hypertension...
  48. ncbi Efficacy and tolerability of telmisartan plus amlodipine in added-risk hypertensive patients
    Robert M Guthrie
    Department of Emergency Medicine, Ohio State University, Columbus, Ohio, USA
    Curr Med Res Opin 27:1995-2008. 2011
    ....
  49. ncbi Effects of telmisartan, a unique angiotensin receptor blocker with selective peroxisome proliferator-activated receptor-gamma-modulating activity, on nitric oxide bioavailability and atherosclerotic change
    Hideyuki Ikejima
    Department of Cardiovascular Medicine, Wakayama Medical University Japan
    J Hypertens 26:964-72. 2008
    ..We therefore investigated the effects of telmisartan on endothelial function and atherosclerotic change in genetically hyperlipidemic rabbits, compared with candesartan, an ARB without PPAR gamma activity...
  50. pmc Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease
    Pablo Garrido-Gil
    Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    J Neuroinflammation 9:38. 2012
    ..PPAR-γ activation inhibits inflammation, and may be responsible for neuroprotective effects, independently of AT1 blocking actions...
  51. ncbi Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor gamma
    Ikuyo Imayama
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, 812 8582 Fukuoka, Japan
    Cardiovasc Res 72:184-90. 2006
    ..Since previous studies have demonstrated that PPARgamma activators suppressed AT1R expression, we examined whether telmisartan affects AT1R expression in vascular smooth muscle cells...
  52. pmc Comparative effectiveness of angiotensin-receptor blockers for preventing macrovascular disease in patients with diabetes: a population-based cohort study
    Tony Antoniou
    Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ont
    CMAJ 185:1035-41. 2013
    ..We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers...
  53. ncbi Angiotensin-receptor blocking agents and the peroxisome proliferator-activated receptor-gamma system
    Michael L Tuck
    Department of Medicine, VA Medical Center, Sepulveda 111E, Building 200, Room 3430, North Hills, CA 91343, USA
    Curr Hypertens Rep 7:240-3. 2005
    ..The results imply that the ARB agent, telmisartan, could treat both the hemodynamic and metabolic aberrations seen in subjects with the metabolic syndrome, such as insulin resistance, glucose intolerance, and hypertension...
  54. ncbi Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha
    Katherine L Lee
    Department of Chemical and Screening Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, USA
    J Med Chem 50:1380-400. 2007
    ..Compound 123 (Ecopladib) is a sub-micromolar inhibitor of cPLA2alpha in the GLU micelle and rat whole blood assays. Compound 123 displayed oral efficacy in the rat carrageenan air pouch and rat carrageenan-induced paw edema models...
  55. ncbi Romiplostim and eltrombopag for immune thrombocytopenia: methods for indirect comparison
    Katy L Cooper
    Universityof Sheffield, Sheffield, United Kingdom
    Int J Technol Assess Health Care 28:249-58. 2012
    ....
  56. ncbi The in vitro metabolism of a pyrethroid insecticide, permethrin, and its hydrolysis products in rats
    Yuri Nakamura
    Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Hiroshima 734 8551, Japan
    Toxicology 235:176-84. 2007
    ..CYP 1A2, 2B1, 2C6, 2D1 and 3A1 exhibited significant oxidase activities in this reaction. Thus, permethrin was hydrolyzed by CES, and PBAlc formed was oxidized to PBAld and PBAcid by the cytochrome P450 system in rats...
  57. pmc Effect of telmisartan on the expression of adiponectin receptors and nicotinamide adenine dinucleotide phosphate oxidase in the heart and aorta in type 2 diabetic rats
    Zhixin Guo
    Department of Endocrinology, Second Hospital, Shanxi Medical University, 382 Wuyi Road, Taiyuan, Shanxi, P R China
    Cardiovasc Diabetol 11:94. 2012
    ....
  58. pmc The Retinoic Acid Receptor-alpha mediates human T-cell activation and Th2 cytokine and chemokine production
    Harry D Dawson
    Laboratory of Immunology, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    BMC Immunol 9:16. 2008
    ....
  59. ncbi Telmisartan at 80 mg/day increases high-molecular-weight adiponectin levels and improves insulin resistance in diabetic patients
    Hiroko Mori
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Kitakyushu 807 8555, Japan
    Adv Ther 29:635-44. 2012
    ..The authors investigated the effect of high-dose telmisartan on serum levels of the high-molecular-weight (HMW) adiponectin in patients with diabetes and hypertension...
  60. ncbi The obese patient with diabetes mellitus: from research targets to treatment options
    Arya M Sharma
    Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Med 119:S17-23. 2006
    ..Clinical trials with telmisartan are currently investigating the effects of RAS blockade on insulin sensitivity in humans...
  61. ncbi The relationship of 3-PBA pyrethroids metabolite and male reproductive hormones among non-occupational exposure males
    Yan Han
    Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, PR China
    Chemosphere 72:785-90. 2008
    ..In adult men, urinary 3-PBA levels were associated with increased LH and reduced E2 levels. On a population level, these reductions show potential public health importance because of widespread exposure to these pesticides...
  62. ncbi Effects of non-occupational environmental exposure to pyrethroids on semen quality and sperm DNA integrity in Chinese men
    Guixiang Ji
    Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China
    Reprod Toxicol 31:171-6. 2011
    ..27, 95%CI: 0.15-0.39, P<0.001). Our results suggest that non-occupational environmental pyrethroids exposure may have a negative impact on sperm DNA integrity and semen quality in Chinese males...
  63. pmc Efficacy of combination therapy with telmisartan plus amlodipine in patients with poorly controlled hypertension
    Hisatoshi Bekki
    ABC Trial Group, Kurume, Japan
    Oxid Med Cell Longev 3:342-6. 2010
    ....
  64. ncbi Effects of permethrin, cypermethrin and 3-phenoxybenzoic acid on rat sperm motility in vitro evaluated with computer-assisted sperm analysis
    Chen Yuan
    2005 Preventive Medicine, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, Nanjing Jiangsu 210029, PR China
    Toxicol In Vitro 24:382-6. 2010
    ..Moreover, 3-PBA did not reduce sperm motility directly at all concentrations and treatment periods. These results provide further evidence that permethrin and cypermethrin can directly affect mature rat sperm motility...
  65. ncbi Retinoic acid stimulates the cell cycle machinery in normal T cells: involvement of retinoic acid receptor-mediated IL-2 secretion
    Aase Ertesvag
    Department of Medical Biochemistry, Institute Group of Basic Medical Sciences, Faculty of Medicine, University of Oslo, N 0317 Oslo, Norway
    J Immunol 169:5555-63. 2002
    ..Taken together, these results suggest that atRA stimulates the cell cycle machinery and proliferation of normal human T cells by increasing IL-2 secretion through mechanisms involving RARs...
  66. pmc Angiotensin receptor type 1 antagonists protect against neuronal injury induced by oxygen-glucose depletion
    X Wu
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Br J Pharmacol 161:33-50. 2010
    ..Here, we have investigated the protective effects of pretreatment with AT(1) receptor antagonists, losartan or telmisartan, against ischaemic insult to neurons in vitro...
  67. ncbi Changes in urinary albumin excretion, inflammatory and oxidative stress markers in ADPKD patients with hypertension
    Tsukasa Nakamura
    Department of Medicine, Shinmatsudo Central General Hospital, Chiba, Japan
    Am J Med Sci 343:46-51. 2012
    ....
  68. pmc Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis
    Pengcheng Luo
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Pharmacol Exp Ther 334:430-8. 2010
    ..These results show not only that sEH KO and its inhibition prevent hyperglycemia in diabetes, but also that sEH KO enhances islet GSIS through the amplifying pathway and decreases islet cell apoptosis in diabetes...
  69. ncbi Telmisartan and amlodipine single-pill combinations vs amlodipine monotherapy for superior blood pressure lowering and improved tolerability in patients with uncontrolled hypertension: results of the TEAMSTA-5 study
    Steen Neldam
    Rødovre Centrum, Rødovre, Denmark
    J Clin Hypertens (Greenwich) 13:459-66. 2011
    ..2% vs 4.3% for pooled T40-T80/A5; P<.0001). Switching patients with uncontrolled BP to a single-pill combination of T40/A5 or T80/A5 is a better treatment option than up-titration to full-dose monotherapy with A10...
  70. ncbi Deferasirox administration for the treatment of non-transfusional iron overload in patients with thalassaemia intermedia
    Vassilis Ladis
    First Department of Paediatrics, Athens University, Thalassaemia Unit, Aghia Sofia Children s Hospital Encephalos Euromedica Laboratories, Rizariou 3, Halandri, Athens Greece
    Br J Haematol 151:504-8. 2010
    ..This small-scale study indicated that deferasirox may be suitable for controlling iron levels in patients with thalassaemia intermedia...
  71. pmc Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase
    Faye Martin
    Department of Biochemistry RT500, Case Western Reserve University, Cleveland, Ohio 44120, USA
    J Biol Chem 285:22651-7. 2010
    ..The structure provides insights into how BAY 58-2667 binds and activates sGC to rescue heme-NO dysfunction in cardiovascular diseases...
  72. ncbi CFTR mediates cadmium-induced apoptosis through modulation of ROS level in mouse proximal tubule cells
    Sebastien l'Hoste
    CNRS FRE 3093, Universite de Nice Sophia Antipolis, Nice Cedex 2, France
    Free Radic Biol Med 46:1017-31. 2009
    ..Our data suggest that CFTR could modulate ROS levels to ensure apoptosis during Cd(2+) exposure by modulating the intracellular content of glutathione...
  73. pmc Chemical inactivation of the cinnamate 4-hydroxylase allows for the accumulation of salicylic acid in elicited cells
    Guillaume A Schoch
    Department of Plant Stress Response, Institute of Plant Molecular Biology, Centre National de la Recherche Scientifique Unité Propre de Recherche 2357, Universite Louis Pasteur, 28 rue Goethe, F 67000 Strasbourg, France
    Plant Physiol 130:1022-31. 2002
    ..Mechanism-based C4H inactivators, thus, are promising tools for the elucidation of the CA-derived SA biosynthetic pathway and for the potentiation of plant defense...
  74. ncbi Effects of veratrine and paeoniflorin on the isolated rat aorta
    H Y Tsai
    Department of Pharmacology and Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan, ROC
    J Ethnopharmacol 66:249-55. 1999
    ..The contraction of veratrine on the isolated rat aorta was via the increase of intracellular calcium which was inhibited by paeoniflorin...
  75. ncbi Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis
    Andreas Knorr
    Institute of Cardiovascular Research, Bayer HealthCare AG, Wuppertal, Germany
    Arzneimittelforschung 58:71-80. 2008
    ..Stable cGMP analogues also reduce the contractile response of hepatic stellate cells. However, cGMP production is downregulated in the cirrhotic liver due to the reduced activity of the endothelial nitric oxide synthase...
  76. ncbi Protective effects of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via antioxidant mechanisms and Ca(2+) antagonism
    Qing Qiu Mao
    School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Cell Mol Neurobiol 30:1059-66. 2010
    ..This neuroprotective effect may be one of the action pathways accounting for the in vivo antidepressant activity of paeoniflorin...
  77. pmc Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells
    L A Hammond
    Division of Cancer Studies, University of Birmingham Medical School, Edgbaston, Birmingham, B15 2TT, UK
    Br J Cancer 85:453-62. 2001
    ..The increased potencies of RAR antagonists, as compared with agonists, suggest that antagonists may be useful in the treatment of prostate carcinoma...
  78. pmc Long-term safety and efficacy of deferasirox (Exjade) for up to 5 years in transfusional iron-overloaded patients with sickle cell disease
    Elliott Vichinsky
    Children s Hospital and Research Center at Oakland, Oakland, CA 94609, USA
    Br J Haematol 154:387-97. 2011
    ..Iron burden was substantially reduced with appropriate dosing in patients treated for at least 4 years...
  79. ncbi Effects of cerebral ischemia-reperfusion on pharmacokinetic fate of paeoniflorin after intravenous administration of Paeoniae Radix extract in rats
    Xihui He
    Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Beijing 100094, China
    J Ethnopharmacol 94:339-44. 2004
    ..These findings suggest that the injuries of ischemia-reperfusion could play an important role in pharmacokinetic process of paeoniflorin...
  80. ncbi Effects of telmisartan and amlodipine in combination on ambulatory blood pressure in stages 1-2 hypertension
    William B White
    Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, Farmington, 06030, USA
    Blood Press Monit 15:205-12. 2010
    ..This is of clinical relevance because out-of-office BP values are of prognostic importance. We studied the effects of combining telmisartan and amlodipine on ambulatory BP in patients with stages 1-2 hypertension...
  81. ncbi Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats
    Jing Liu
    Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China
    Brain Res 1089:162-70. 2006
    ..Our results demonstrated that PF could attenuate cognitive deficit and brain damage induced by chronic cerebral hypoperfusion and that suppression of neuroinflammatory reaction in brain might be involved in PF-induced neuroprotection...
  82. pmc BenR, a XylS homologue, regulates three different pathways of aromatic acid degradation in Pseudomonas putida
    C E Cowles
    Department of Microbiology, The University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 182:6339-46. 2000
    ..The action of BenR in repressing 4-HBA uptake is probably indirect...
  83. ncbi Involvement of multitargets in paeoniflorin-induced preconditioning
    Dong Mei Chen
    Department of Pharmacology, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi Tech Park, Pudong Shanghai 201203, China
    J Pharmacol Exp Ther 319:165-80. 2006
    ....
  84. ncbi Paeoniflorin attenuates schistosomiasis japonica-associated liver fibrosis through inhibiting alternative activation of macrophages
    Deyong Chu
    Department of Microbiology and Parasitology, Anhui Key Laboratory of Microbiology and Parasitology, Anhui Medical University, Hefei, China
    Parasitology 138:1259-71. 2011
    ..PAE might be a promising prophylactic agent for hepatic granuloma and fibrosis of schistosomiasis japonica...
  85. ncbi The pyrethroid metabolites 3-phenoxybenzoic acid and 3-phenoxybenzyl alcohol do not exhibit estrogenic activity in the MCF-7 human breast carcinoma cell line or Sprague-Dawley rats
    Brian Laffin
    Department of Veterinary Integrative Biosciences at Texas A and M University, 107 VMA Building, College Station, TX 77843 4458, USA
    Toxicology 267:39-44. 2010
    ..0, 5.0, and 1.0 mg/kg) once a day with the metabolites beginning 1 day post-weaning until the onset of puberty as evidenced by vaginal opening (VO). Again, neither metabolite had any effect on the onset of VO...
  86. ncbi Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats
    Irina Tsoy Nizamutdinova
    Department of Pharmacology, School of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju, Korea
    Planta Med 74:14-8. 2008
    ..The results show that both PF and PN reduced myocardial damage in rat through protection from apoptosis, suggesting that Paeonia albiflora Pallas might be useful in treating myocardial infarction...
  87. pmc Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation
    Jun Yan Liu
    Department of Entomology and UCD Cancer Research Center, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Br J Pharmacol 156:284-96. 2009
    ..Here we present the evaluation of four sEHIs for improved pharmacokinetic properties and the anti-inflammatory effects of one sEHI...
  88. ncbi Paeoniflorin suppress NF-kappaB activation through modulation of I kappaB alpha and enhances 5-fluorouracil-induced apoptosis in human gastric carcinoma cells
    Hao Wu
    Department of Oncology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, PR China
    Biomed Pharmacother 62:659-66. 2008
    ..We sought to determine whether paeoniflorin enhances 5-fluorouracil-induced apoptosis in human gastric carcinoma cells, and, if so, to determine the relationship between this apoptosis and NF-kappaB activation...
  89. ncbi Angiotensin II receptor blockers downsize adipocytes in spontaneously type 2 diabetic rats with visceral fat obesity
    Yutaka Mori
    Department of Internal Medicine, National Hospital Organization, Utsunomiya National Hospital, Kawachi gun, Tochigi, Japan
    Am J Hypertens 20:431-6. 2007
    ....
  90. ncbi Preventing stroke: the PRoFESS, ONTARGET, and TRANSCEND trial programs
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    J Hypertens Suppl 27:S31-6. 2009
    ..In a combined analysis of PRoFESS and TRANSCEND, the incidence of the composite of stroke, myocardial infarction, or vascular death was 12.8% for telmisartan versus 13.8% for placebo (hazard ratio 0.91; 95% CI 0.85-0.98; P = 0.013)...
  91. pmc Renal protection in diabetes: lessons from ONTARGET
    Eberhard Ritz
    Universitat Erlangen, Medizinische Klinik IV, Erlangen, Germany
    Cardiovasc Diabetol 9:60. 2010
    ....
  92. ncbi Iron chelation treatment with deferasirox prior to high-dose chemotherapy and autologous stem cell transplantation may reduce the risk of hepatic veno-occlusive disease in children with high-risk solid tumors
    Hee Won Chueh
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul, Republic of Korea
    Pediatr Blood Cancer 58:441-7. 2012
    ....
  93. ncbi Telmisartan improves vascular function and reduces platelet activation in rats with streptozotocin-induced diabetes mellitus
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Pharmacol Res 56:217-23. 2007
    ..Telmisartan normalizes vascular dysfunction and reduces platelet activation in diabetic rats. These effects may contribute to the reduction of cardiovascular events by angiotensin II receptor blockers in diabetic patients...
  94. ncbi Telmisartan increases fatty acid oxidation in skeletal muscle through a peroxisome proliferator-activated receptor-gamma dependent pathway
    Ken Sugimoto
    Department of Laboratory Medicine, University of California, San Francisco, CA, USA
    J Hypertens 26:1209-15. 2008
    ..As muscle fatty acid oxidation is a major determinant of energy expenditure, we investigated the effects of telmisartan on skeletal muscle fatty acid oxidation in a rat model of the metabolic syndrome...
  95. ncbi Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase
    Peter Schmidt
    Institute of Cardiovascular Research, Bayer AG, Aprather Weg 18a, D 42096, Wuppertal, Germany
    Eur J Pharmacol 468:167-74. 2003
    ..These results show the different activation patterns of both compounds and demonstrate their value as tools to investigate the mechanisms that underlie soluble guanylyl cyclase activation...
  96. pmc ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice
    James J Donkin
    Department of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    J Biol Chem 285:34144-54. 2010
    ..These results suggest that ABCA1 contributes to several beneficial effects of the LXR agonist GW3965 in APP/PS1 mice...
  97. pmc Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists
    Da Zhi Liu
    Department of Pharmacology, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Pudong, Shanghai 201203, China
    Br J Pharmacol 146:604-11. 2005
    ..However, PF had no 'well-known' cardiovascular side effects of classical A1R agonists. The results suggest that PF might have the potential therapeutic value as an anti-stroke drug...
  98. ncbi BAY 58-2667, a nitric oxide-independent guanylyl cyclase activator, pharmacologically post-conditions rabbit and rat hearts
    Thomas Krieg
    Department of Cardiology, Ernst Moritz Arndt University, Loefflerstr 23, 17487 Greifswald, Germany
    Eur Heart J 30:1607-13. 2009
    ..We tested whether BAY-58 could make both rabbit and rat hearts resistant to infarction when given at the end of an ischaemic insult...
  99. ncbi Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats
    Liang Xiao
    Department of Pharmacology, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang, Shanghai 201203, China
    Life Sci 78:413-20. 2005
    ..Transient MCAO also induced impairments in TP and performance in the water maze. Treatment with PF was able to reverse or alleviate these impairments. These results indicate that PF may be effective for treatment of stroke...
  100. ncbi Raising HDL cholesterol without inducing hepatic steatosis and hypertriglyceridemia by a selective LXR modulator
    Bowman Miao
    Cardiovascular Biology, Bristol Myers Squibb Company, Experimental Station, Wilmington, DE 19880, USA
    J Lipid Res 45:1410-7. 2004
    ..This demonstration that tissue and gene selective modulation is possible with selective LXR modulators has positive implications for the development of this class of antiatherosclerotic agents...
  101. ncbi Synthetic LXR agonists increase LDL in CETP species
    Pieter H E Groot
    Cardiovascular Center for Excellence in Drug Discovery, GlaxoSmithKline, King of Prussia, Pa 19406 0939, USA
    J Lipid Res 46:2182-91. 2005
    ..These results reveal additional problems associated with current synthetic LXR agonists and emphasize the importance of profiling compounds in preclinical species with a more human-like LXR response and lipoprotein metabolism...

Research Grants64

  1. ASTATINE AND IODINE RADIOLABELED MONOCLONAL ANTIBODIES
    Michael Rod Zalutsky; Fiscal Year: 2013
    ..Our studies revealed that radio iodination of anti-EGFRvIII mAbs using reagents containing benzoates bearing charged substituent's or D-amino acid peptides significantly improved retention of radioactivity in ..
  2. BXR SIGNALING IN VERTEBRATE DEVELOPMENT
    Bruce Blumberg; Fiscal Year: 2004
    ..isolated and characterized a novel nuclear receptor activated by a class of endogenous substituted alkyl benzoates. These compounds comprise a novel class of hormone receptor ligand and are related the B-complex vitamins p-..
  3. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  4. Adrenergic Antagonism During Murine Candidiasis
    Brad Spellberg; Fiscal Year: 2008
    ..For these reasons, the potential for adrenergic antagonism to act as an effective immunotherapy is highly meritorious of investigation in this training application. ..
  5. Modulation of Iron Deposition in SCD and Other Hemoglobinopathies
    ELLIOTT P contact VICHINSKY; Fiscal Year: 2010
    ....
  6. CARDIOPROTECTIVE EFFECT--NEW CHELATORS FOR THALASSEMIA
    Chaim Hershko; Fiscal Year: 2001
    ..abstract_text> ..
  7. E/BETA THALASSEMIA--NATURAL HISTORY & RESPONSE TO CHEMO
    Elliott Vichinsky; Fiscal Year: 2002
    ..In summary, if this study is successful, it will change the approach to Hb E/B worldwide and result in improved quality of life and decreased mortality. (End of Abstract) ..
  8. Eighth Cooley's Anemia Symposium
    Elliott Vichinsky; Fiscal Year: 2005
    ....
  9. Imaging of O6-Alkylguanine-DNA Alkyltransferase
    Ganesan Vaidyanathan; Fiscal Year: 2005
    ..In summary, this proposal seeks to determine whether the development of a suitable agent for the imaging of tumor AGT will facilitate chemotherapy planning, thereby improving the outcome of alkylator chemotherapy. ..
  10. RESIN-BASED REMINERALIZING CEMENTS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2009
    ..Completion of this research will lead to Ca- PO4 cements and composites with improved adhesion to dentin and improved strength for ART and the treatment of root caries. ..
  11. KIDNEY SPECIFIC GENE TRANSFER IN HYPERTENSION
    Theodore Kurtz; Fiscal Year: 2003
    ..Under this alternative hypothesis, the results of the cDNA microarray analysis will be used to identify potential downstream target genes whose expression is altered by the primary genetic defect on chromosome 1. ..
  12. WHY DO METABOLIC RISK FACTORS CLUSTER WITH HYPERTENSION?
    Theodore Kurtz; Fiscal Year: 2003
    ....
  13. MIBG ANALOGUE RADIOPHARMACEUTICALS
    Ganesan Vaidyanathan; Fiscal Year: 2001
    ..Strategies to augment tumor-to-normal tissue ratios will be investigated. The outcome of this study should help improve the endoradiotherapy of neuroendocrine tumors and possibly of medulloblastoma. ..
  14. IMPROVED PREVENTIVE/RESTORATIVE RESINS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2006
    ..The data gathered in these experiments will serve to support a larger R01 grant application with the long-term objectives of developing improved durable materials for adhesives and adhesive composites. [unreadable] [unreadable]..
  15. Cardiac Function and Cardiac iron (T2*) in Thalassemia
    John Wood; Fiscal Year: 2007
    ..These studies will provide the necessary groundwork for longitudinal studies of cardiac iron load on cardiac performance in thalassemia patients. ..
  16. Treatment of Fungal Infections with ATAK Cells
    Ashraf Ibrahim; Fiscal Year: 2004
    ..Furthermore, the genetic construct targeting ATAK cells to Candida can easily be adapted to any other pathogen against which a MAb has been raised. ..
  17. Novel Antifungal Strategies for Lethal Mucormycosis
    Ashraf Ibrahim; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  18. Proteomics and Biomarkers for Hepatocellular Cancer
    Nezam Afdhal; Fiscal Year: 2004
    ..These studies may lead to identification of more specific and sensitive biomarkers for HCC in HCV which can then be validated further in prospective clinical trials. ..
  19. PROTEIN LIPID INTERACTIONS IN GALLSTONE PATHOGENESIS
    Nezam Afdhal; Fiscal Year: 2002
    ..These studies may lead to strategies for the prevention and non-surgical therapy of this very common disease. ..
  20. Salsalate: A Diabetes Treatment for Carbonyl, Oxidative & Nitrosative Stress
    JOSHUA ISRAEL BARZILAY; Fiscal Year: 2010
    ..If effective, this treatment could reduce the risk of heart attacks and strokes that frequently occur in people with diabetes. ..
  21. Antiviral Therapy in African Americans with HCV
    Nezam Afdhal; Fiscal Year: 2005
    ..Specimens of liver tissue and serum will be collected for basic studies on viral resistance. These studies should help determine the best therapy for AA with HCV. ..
  22. African American Men Prostate & Colorectal Cancer Belief
    Thomas Arcury; Fiscal Year: 2007
    ..A preliminary framework of the intervention strategy for this R01 application will be developed and evaluated as part of this project. [unreadable] [unreadable]..
  23. Selective Modulation of Thyroid Receptor Action
    John Baxter; Fiscal Year: 2007
    ..This study will expand our understanding of selective TR modulation in specific and NR action in general. ..
  24. A Novel Target for New Anti-Anthrax Drugs
    Wayne Brouillette; Fiscal Year: 2007
    ..Selectivity for the inhibition of Bacillus NAD synthetase over the human (erythrocyte) enzyme will also be evaluated. ..
  25. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  26. CLINICAL TRIALS OF FLAVOPIRIDOL WITH CHEMOTHERAPY
    Gary Schwartz; Fiscal Year: 2008
    ..Continue to examine the mechanisms by which flavopiridol potentiates CPT-11 induced apoptosis, which should provide the opportunity to identify new biomarkers of response for these flavopiridol drug combinations. ..
  27. Angll and PPARy/LXR in Atherosclerosis
    Willa Hsueh; Fiscal Year: 2008
    ..4) Determine whether PPARgamma ligands or LXRaalpha ligands can induce regression of established atherosclerosis. ..
  28. Community-Based Participatory Approach to Farmworker Housing, Exposures & Health
    Thomas A Arcury; Fiscal Year: 2010
    ....
  29. Roles of polymorphic COMT, tea polyphenols and proteasome in cancer prevention
    QING PING DOU; Fiscal Year: 2010
    ..abstract_text> ..
  30. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  31. The roles of apolipoprotein A-IV structure and lipid affinity in its function
    W Davidson; Fiscal Year: 2009
    ....
  32. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  33. Electroyte Transport in Small Airways
    Paul Quinton; Fiscal Year: 2009
    ..Correctly understanding this fundamental structure/function is critical to developing effective therapies. ..
  34. AASK Cohort Study
    George Bakris; Fiscal Year: 2007
    ..Such results might eventually lead to new strategies that delay or prevent ESRD. ..
  35. Apolipoprotein-mediated cholesterol efflux
    W Davidson; Fiscal Year: 2008
    ..This understanding will form a basis for new interventions designed to enhance apolipoprotein-mediated cholesterol efflux from cells, particularly those within the atherosclerotic vessel wall. ..
  36. HIPPOCAMPAL NETWORK STRUCTURE AND FUNCTION IN EPILEPSY
    ROBERT SLOVITER; Fiscal Year: 2006
    ..abstract_text> ..
  37. Mechanisms of CVD and Endothelial Dysfunction in Obesity
    Willa Hsueh; Fiscal Year: 2006
    ..Early intervention is critical if we are to prevent these two major diseases, which may, indeed, be the same disease. ..
  38. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
  39. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  40. ANGIOTENSIN II AND MITOGEN ACTIVATED PROTEIN KINASE
    Willa Hsueh; Fiscal Year: 2003
    ..5) Investigate the mechanism of transcription at regulation of PAI-1 by hyperglycemia AngII, insulin and the MAPK inhibitor in cultured rat cardiac fibroblasts. ..
  41. NEURAL CIRCUITRY MEDIATING SUCROSE INDUCED ANALGESIA
    Matthew Ennis; Fiscal Year: 2003
    ..This work will lead to a better understanding of neural circuits controlling taste and pain and how these circuits regulate analgesia in newborns. ..
  42. Synthesis of Pyran Bicyclic Natural Products
    SALVATORE LEPORE; Fiscal Year: 2003
    ..Besides their application in this proposed work, these three key reactions taken together are also expected to facilitate the future synthesis of a wide variety pyran bicyclic compounds. ..
  43. ERYTHROCYTAPHERESIS TO LOWER IRON LOADING IN THALASSEMIA
    Alan Cohen; Fiscal Year: 2002
    ....
  44. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  45. PPARGAMMA AND AII IN GLOMERULOSCLEROSIS
    Willa Hsueh; Fiscal Year: 2002
    ..abstract_text> ..
  46. MODULATION OF NEUROTRANSMITTER RELEASE BY CANNABINOIDS
    Andrew Gifford; Fiscal Year: 2002
    ..Furthermore, these experiments will give information on the mode of action of cannabinoid antagonists and could suggest novel therapeutic uses for this new class of compounds. ..
  47. CL-/HCO3- EXCHANGE IN CYSTIC FIBROSIS SWEAT GLANDS
    Paul Quinton; Fiscal Year: 2001
    ..Defining HCO3 ion-transport and its relevance to CFTR function should lend much to explaining, and hopefully, ameliorating these problems. ..
  48. Involvement of mGluR5 in inhibitory avoidance and aging
    Agnes Simonyi; Fiscal Year: 2004
    ..This information may also be useful for therapeutic research investigating the potential use of mGluR ligands in age-related neurodegenerative disorders, such as Alzheimer's disease. ..
  49. Casa A Campo: Pesticide Safety for Farmworkers' Families
    Thomas Arcury; Fiscal Year: 2004
    ....
  50. Biacore T100
    Jeffrey Toretsky; Fiscal Year: 2006
    ..These enhanced capabilities of the T100 will allow projects investigating many types of biologic processes to advance. ..
  51. Solid-Phase Approach to the Synthesis of CII PET Tracers
    SALVATORE LEPORE; Fiscal Year: 2005
    ..abstract_text> ..
  52. Pathophysiology of thiamine-responsive anemia syndrome
    Ellis Neufeld; Fiscal Year: 2006
    ....
  53. Farmwoker Environmental Health Research Comparable Data
    Thomas Arcury; Fiscal Year: 2004
    ..The purpose of limiting the size of the conference is to facilitate active interaction, discussion and debate among leaders in the field. ..
  54. PET Studies of Alcohol Distribution and Metabolism
    Andrew Gifford; Fiscal Year: 2005
    ..abstract_text> ..
  55. Differences in CAM Use Among Minority Older Adults
    Thomas Arcury; Fiscal Year: 2005
    ..abstract_text> ..
  56. NEW DEVELOPMENTS IN ORGANOCOPPER CHEMISTRY
    R Dieter; Fiscal Year: 2004
    ..The proposed synthetic routes to pyrrolidine aza sugars will develop the potential synthetic power of alpha-aminoalkylcuprate chemistry. ..
  57. LTQ Linear Ion Trap Mass Spectrometer System
    Susan Weintraub; Fiscal Year: 2005
    ..Project descriptions for 9 major users, 4 minor users and 3 future users are presented. ..
  58. MENTORING FOR NEW CANCER THERAPEAUTICS
    Gary Schwartz; Fiscal Year: 2005
    ..This K24 award mechanism represents the essence of what we are proposing and for which support is needed. ..
  59. PREOPTIC AREA AND PHARMACOLOGIC SLEEP INDUCTION
    Paul Vezina; Fiscal Year: 2001
    ....
  60. ANALYSIS OF PAIR OF RULE GENES IN SEQUENTIAL SEGMENTATIO
    DAVID WEISBLAT; Fiscal Year: 2003
    ..abstract_text> ..
  61. ESTROGEN AND COGNITION OVER THE LIFESPAN
    Thomas Foster; Fiscal Year: 2009
    ..abstract_text> ..
  62. HIV ASSOCIATED NEPHROPATHY IN DRUG ADDICTS
    Pravin Singhal; Fiscal Year: 2007
    ..3. Drugs modulation of the renin-angiotensin system contributes to the progression of renal lesions in mice with HIVAN. [unreadable] [unreadable] [unreadable]..