benzoates

Summary

Summary: Salts and esters of BENZOIC ACID that possess antibacterial and antifungal properties. They are used as preservatives in pharmaceuticals, cosmetics, and foods.

Top Publications

  1. ncbi Effects of antihypertensive treatment with angiotensin II receptor blockers on lipid profile: an open multi-drug comparison trial
    Stella Maria G Kyvelou
    Hypertension Unit, 1st Cardiology Department, Athens University, Hippokration Hospital, Greece
    Hellenic J Cardiol 47:21-8. 2006
  2. doi Telmisartan, ramipril, or both in patients at high risk for vascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 358:1547-59. 2008
  3. doi Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression
    Jiu Chang Zhong
    Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Vascular Biology, Shanghai Institute of Hypertension, Shanghai 200025, China
    Regul Pept 166:90-7. 2011
  4. doi Low dose of telmisartan prevents ischemic brain damage with peroxisome proliferator-activated receptor-gamma activation in diabetic mice
    Jun Iwanami
    Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan
    J Hypertens 28:1730-7. 2010
  5. pmc Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
    Johannes Peter Stasch
    Institute of Cardiovascular Research, Bayer HealthCare, Wuppertal, Germany
    J Clin Invest 116:2552-61. 2006
  6. ncbi Treating the metabolic syndrome: telmisartan as a peroxisome proliferator-activated receptor-gamma activator
    T W Kurtz
    Laboratory of Medicine, University of California San Francisco, 185 Berry Street, Suite 290, San Francisco, CA 94107, USA
    Acta Diabetol 42:S9-16. 2005
  7. pmc Role of the retinoic acid receptor-α in HIV-associated nephropathy
    Krishna K Ratnam
    Division of Nephrology, Mount Sinai School of Medicine, New York, New York, USA
    Kidney Int 79:624-34. 2011
  8. ncbi Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity
    Stephen C Benson
    Department of Biological Sciences, California State University, Hayward, USA
    Hypertension 43:993-1002. 2004
  9. ncbi Telmisartan: a different angiotensin II receptor blocker protecting a different population?
    M Burnier
    Division of Nephrology and Hypertension Consultation, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Int Med Res 37:1662-79. 2009
  10. pmc NO synthase-generated NO acts downstream of auxin in regulating Fe-deficiency-induced root branching that enhances Fe-deficiency tolerance in tomato plants
    Chong Wei Jin
    College of Environmental and Resource Science, Zhejiang University, Hangzhou 310058, China
    J Exp Bot 62:3875-84. 2011

Research Grants

Detail Information

Publications238 found, 100 shown here

  1. ncbi Effects of antihypertensive treatment with angiotensin II receptor blockers on lipid profile: an open multi-drug comparison trial
    Stella Maria G Kyvelou
    Hypertension Unit, 1st Cardiology Department, Athens University, Hippokration Hospital, Greece
    Hellenic J Cardiol 47:21-8. 2006
    ..This study was conducted to evaluate blood pressure control and the plasma lipid profile in hypertensive patients after six months' treatment with ARB...
  2. doi Telmisartan, ramipril, or both in patients at high risk for vascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 358:1547-59. 2008
    ..We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes...
  3. doi Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression
    Jiu Chang Zhong
    Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Vascular Biology, Shanghai Institute of Hypertension, Shanghai 200025, China
    Regul Pept 166:90-7. 2011
    ..In conclusion, telmisartan treatment attenuates vascular hypertrophy in SHR by the modulation of ACE2 and profilin-1 expression with a marked reversal of ERK1/2 and JNK phosphorylation signaling pathways...
  4. doi Low dose of telmisartan prevents ischemic brain damage with peroxisome proliferator-activated receptor-gamma activation in diabetic mice
    Jun Iwanami
    Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan
    J Hypertens 28:1730-7. 2010
    ..Telmisartan is a unique AT1 receptor blocker with a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonistic action. Activation of PPAR-gamma could prevent inflammation and brain damage...
  5. pmc Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
    Johannes Peter Stasch
    Institute of Cardiovascular Research, Bayer HealthCare, Wuppertal, Germany
    J Clin Invest 116:2552-61. 2006
    ....
  6. ncbi Treating the metabolic syndrome: telmisartan as a peroxisome proliferator-activated receptor-gamma activator
    T W Kurtz
    Laboratory of Medicine, University of California San Francisco, 185 Berry Street, Suite 290, San Francisco, CA 94107, USA
    Acta Diabetol 42:S9-16. 2005
    ..If the preliminary data are supported by the results of ongoing large-scale clinical studies, telmisartan could have a central role in the prevention and treatment of metabolic syndrome, diabetes and atherosclerosis...
  7. pmc Role of the retinoic acid receptor-α in HIV-associated nephropathy
    Krishna K Ratnam
    Division of Nephrology, Mount Sinai School of Medicine, New York, New York, USA
    Kidney Int 79:624-34. 2011
    ..Thus, a defect in the endogenous synthesis of retinoic acid contributes to loss of the protection by retinoic acid in HIVAN. Hence, RARα agonists may be potential agents for the treatment of HIVAN...
  8. ncbi Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity
    Stephen C Benson
    Department of Biological Sciences, California State University, Hayward, USA
    Hypertension 43:993-1002. 2004
    ....
  9. ncbi Telmisartan: a different angiotensin II receptor blocker protecting a different population?
    M Burnier
    Division of Nephrology and Hypertension Consultation, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Int Med Res 37:1662-79. 2009
    ..A class effect for ARBs cannot be assumed. To date, telmisartan is the only ARB that has been shown to reduce cardiovascular risk in at-risk cardiovascular patients...
  10. pmc NO synthase-generated NO acts downstream of auxin in regulating Fe-deficiency-induced root branching that enhances Fe-deficiency tolerance in tomato plants
    Chong Wei Jin
    College of Environmental and Resource Science, Zhejiang University, Hangzhou 310058, China
    J Exp Bot 62:3875-84. 2011
    ....
  11. ncbi Angiotensin-receptor blocking agents and the peroxisome proliferator-activated receptor-gamma system
    Michael L Tuck
    Department of Medicine, VA Medical Center, Sepulveda 111E, Building 200, Room 3430, North Hills, CA 91343, USA
    Curr Hypertens Rep 7:240-3. 2005
    ..The results imply that the ARB agent, telmisartan, could treat both the hemodynamic and metabolic aberrations seen in subjects with the metabolic syndrome, such as insulin resistance, glucose intolerance, and hypertension...
  12. pmc Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis
    Pengcheng Luo
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Pharmacol Exp Ther 334:430-8. 2010
    ..These results show not only that sEH KO and its inhibition prevent hyperglycemia in diabetes, but also that sEH KO enhances islet GSIS through the amplifying pathway and decreases islet cell apoptosis in diabetes...
  13. doi Eltrombopag for management of chronic immune thrombocytopenia (RAISE): a 6-month, randomised, phase 3 study
    Gregory Cheng
    Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Lancet 377:393-402. 2011
    ..We aimed to compare the response to once daily eltrombopag versus placebo in patients with chronic immune thrombocytopenia during a 6-month period...
  14. ncbi Dual repressive effect of angiotensin II-type 1 receptor blocker telmisartan on angiotensin II-induced and estradiol-induced uterine leiomyoma cell proliferation
    Aki Isobe
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Hum Reprod 23:440-6. 2008
    ..Elevated blood pressure has an independent, positive association with risk for clinically detected uterine leiomyoma. Angiotensin II (Ang II) is a key biological peptide in the renin-angiotensin system that regulates blood pressure...
  15. doi Long-term treatment with the AT1-receptor antagonist telmisartan inhibits biglycan accumulation in murine atherosclerosis
    Nadine Nagy
    Institut fur Pharmakologie, Universitatsklinikum Essen, Universitat Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Basic Res Cardiol 105:29-38. 2010
    ..Thus, biglycan is a pleiotropic target of telmisartan that might contribute to the anti-atherogenic effects of this AT1-antagonist...
  16. doi Iron chelation with deferasirox in adult and pediatric patients with thalassemia major: efficacy and safety during 5 years' follow-up
    M Domenica Cappellini
    Universita di Milano, Ca Granda Foundation Istituto di Ricovero e Cura a Carattere Scientifico corrected IRCCS, Milan, Italy
    Blood 118:884-93. 2011
    ..This trial was registered at www.clinicaltrials.gov as #NCT00171210...
  17. ncbi Antiproliferative activity of paeoniflorin is through cell cycle arrest and the Fas/Fas ligand-mediated apoptotic pathway in human non-small cell lung cancer A549 cells
    Jen Yu Hung
    Division of Pulmonary and Critical Care Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Clin Exp Pharmacol Physiol 35:141-7. 2008
    ..4. This is the first study to show that the induction of p21/WAF1 and the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of PF in A549 cells...
  18. ncbi Nitric oxide-independent stimulation of soluble guanylate cyclase with BAY 41-2272 in cardiovascular disease
    Guido Boerrigter
    Cardiorenal Research Laboratory, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cardiovasc Drug Rev 25:30-45. 2007
    ..Finally, the significance of the novel NO- and heme-independent sGC activator BAY 58-2667, which activates two forms of NO-insensitive sGC, is briefly discussed...
  19. doi Telmisartan suppresses cerebral injury in a murine model of transient focal ischemia
    Yukiko Kasahara
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    Brain Res 1340:70-80. 2010
    ....
  20. ncbi PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin
    Ronald Clasen
    Center for Cardiovascular Research, Institut fur Pharmakologie und Toxikologie, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Hypertension 46:137-43. 2005
    ..ARB-induced adiponectin stimulation is likely to be mediated via PPARgamma activation involving a post-transcriptional mechanism...
  21. doi Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial
    S Yusuf
    Lancet 372:1174-83. 2008
    ..We therefore assessed whether the angiotensin-receptor blocker telmisartan would be effective in patients intolerant to ACE inhibitors with cardiovascular disease or diabetes with end-organ damage...
  22. ncbi Effects of veratrine and paeoniflorin on the isolated rat aorta
    H Y Tsai
    Department of Pharmacology and Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan, ROC
    J Ethnopharmacol 66:249-55. 1999
    ..The contraction of veratrine on the isolated rat aorta was via the increase of intracellular calcium which was inhibited by paeoniflorin...
  23. doi Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis
    Andreas Knorr
    Institute of Cardiovascular Research, Bayer HealthCare AG, Wuppertal, Germany
    Arzneimittelforschung 58:71-80. 2008
    ..Stable cGMP analogues also reduce the contractile response of hepatic stellate cells. However, cGMP production is downregulated in the cirrhotic liver due to the reduced activity of the endothelial nitric oxide synthase...
  24. doi Protective effects of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via antioxidant mechanisms and Ca(2+) antagonism
    Qing Qiu Mao
    School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Cell Mol Neurobiol 30:1059-66. 2010
    ..This neuroprotective effect may be one of the action pathways accounting for the in vivo antidepressant activity of paeoniflorin...
  25. doi Effects of telmisartan and amlodipine in combination on ambulatory blood pressure in stages 1-2 hypertension
    William B White
    Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, Farmington, 06030, USA
    Blood Press Monit 15:205-12. 2010
    ..This is of clinical relevance because out-of-office BP values are of prognostic importance. We studied the effects of combining telmisartan and amlodipine on ambulatory BP in patients with stages 1-2 hypertension...
  26. ncbi Effects of cerebral ischemia-reperfusion on pharmacokinetic fate of paeoniflorin after intravenous administration of Paeoniae Radix extract in rats
    Xihui He
    Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Beijing 100094, China
    J Ethnopharmacol 94:339-44. 2004
    ..These findings suggest that the injuries of ischemia-reperfusion could play an important role in pharmacokinetic process of paeoniflorin...
  27. pmc BenR, a XylS homologue, regulates three different pathways of aromatic acid degradation in Pseudomonas putida
    C E Cowles
    Department of Microbiology, The University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 182:6339-46. 2000
    ..The action of BenR in repressing 4-HBA uptake is probably indirect...
  28. pmc Long-term safety and efficacy of deferasirox (Exjade) for up to 5 years in transfusional iron-overloaded patients with sickle cell disease
    Elliott Vichinsky
    Children s Hospital and Research Center at Oakland, Oakland, CA 94609, USA
    Br J Haematol 154:387-97. 2011
    ..Iron burden was substantially reduced with appropriate dosing in patients treated for at least 4 years...
  29. ncbi Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats
    Jing Liu
    Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China
    Brain Res 1089:162-70. 2006
    ..Our results demonstrated that PF could attenuate cognitive deficit and brain damage induced by chronic cerebral hypoperfusion and that suppression of neuroinflammatory reaction in brain might be involved in PF-induced neuroprotection...
  30. pmc Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells
    L A Hammond
    Division of Cancer Studies, University of Birmingham Medical School, Edgbaston, Birmingham, B15 2TT, UK
    Br J Cancer 85:453-62. 2001
    ..The increased potencies of RAR antagonists, as compared with agonists, suggest that antagonists may be useful in the treatment of prostate carcinoma...
  31. doi Modulation of PPAR-gamma by telmisartan protects the heart against myocardial infarction in experimental diabetes
    Sameer Goyal
    Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Chem Biol Interact 185:271-80. 2010
    ..In addition to class effects of ARBs, telmisartan reduces oxidative stress and apoptosis and improves cardiac function via the PPAR-gamma pathway...
  32. ncbi Involvement of multitargets in paeoniflorin-induced preconditioning
    Dong Mei Chen
    Department of Pharmacology, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi Tech Park, Pudong Shanghai 201203, China
    J Pharmacol Exp Ther 319:165-80. 2006
    ....
  33. doi Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats
    Irina Tsoy Nizamutdinova
    Department of Pharmacology, School of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju, Korea
    Planta Med 74:14-8. 2008
    ..The results show that both PF and PN reduced myocardial damage in rat through protection from apoptosis, suggesting that Paeonia albiflora Pallas might be useful in treating myocardial infarction...
  34. doi The pyrethroid metabolites 3-phenoxybenzoic acid and 3-phenoxybenzyl alcohol do not exhibit estrogenic activity in the MCF-7 human breast carcinoma cell line or Sprague-Dawley rats
    Brian Laffin
    Department of Veterinary Integrative Biosciences at Texas A and M University, 107 VMA Building, College Station, TX 77843 4458, USA
    Toxicology 267:39-44. 2010
    ..0, 5.0, and 1.0 mg/kg) once a day with the metabolites beginning 1 day post-weaning until the onset of puberty as evidenced by vaginal opening (VO). Again, neither metabolite had any effect on the onset of VO...
  35. doi Blood pressure control by the nifedipine GITS-telmisartan combination in patients at high cardiovascular risk: the TALENT study
    Giuseppe Mancia
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Italy
    J Hypertens 29:600-9. 2011
    ..Because of the complementary mechanism of action and the evidence of cardiovascular protective effects they include the combination of a calcium antagonist and an angiotensin receptor antagonist among the priorital ones to employ...
  36. pmc Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation
    Jun Yan Liu
    Department of Entomology and UCD Cancer Research Center, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Br J Pharmacol 156:284-96. 2009
    ..Here we present the evaluation of four sEHIs for improved pharmacokinetic properties and the anti-inflammatory effects of one sEHI...
  37. doi Telmisartan inhibits vasoconstriction via PPARγ-dependent expression and activation of endothelial nitric oxide synthase
    Chi Yung Yuen
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Cardiovasc Res 90:122-9. 2011
    ....
  38. doi Deferasirox reduces iron overload significantly in nontransfusion-dependent thalassemia: 1-year results from a prospective, randomized, double-blind, placebo-controlled study
    Ali T Taher
    American University of Beirut, Beirut, Lebanon
    Blood 120:970-7. 2012
    ..8%), and diarrhea (n = 6; 3.6%). This is the first randomized study showing that iron chelation with deferasirox significantly reduces iron overload in NTDT patients with a frequency of overall adverse events similar to placebo...
  39. doi Paeoniflorin attenuates schistosomiasis japonica-associated liver fibrosis through inhibiting alternative activation of macrophages
    Deyong Chu
    Department of Microbiology and Parasitology, Anhui Key Laboratory of Microbiology and Parasitology, Anhui Medical University, Hefei, China
    Parasitology 138:1259-71. 2011
    ..PAE might be a promising prophylactic agent for hepatic granuloma and fibrosis of schistosomiasis japonica...
  40. pmc Telmisartan ameliorates lipopolysaccharide-induced innate immune response through peroxisome proliferator-activated receptor-γ activation in human monocytes
    Tao Pang
    Section on Pharmacology, Division of Intramural Research Programs, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Hypertens 30:87-96. 2012
    ....
  41. doi Paeoniflorin suppress NF-kappaB activation through modulation of I kappaB alpha and enhances 5-fluorouracil-induced apoptosis in human gastric carcinoma cells
    Hao Wu
    Department of Oncology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, PR China
    Biomed Pharmacother 62:659-66. 2008
    ..We sought to determine whether paeoniflorin enhances 5-fluorouracil-induced apoptosis in human gastric carcinoma cells, and, if so, to determine the relationship between this apoptosis and NF-kappaB activation...
  42. pmc Renal protection in diabetes: lessons from ONTARGET
    Eberhard Ritz
    Universitat Erlangen, Medizinische Klinik IV, Erlangen, Germany
    Cardiovasc Diabetol 9:60. 2010
    ....
  43. doi Preventing stroke: the PRoFESS, ONTARGET, and TRANSCEND trial programs
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    J Hypertens Suppl 27:S31-6. 2009
    ..In a combined analysis of PRoFESS and TRANSCEND, the incidence of the composite of stroke, myocardial infarction, or vascular death was 12.8% for telmisartan versus 13.8% for placebo (hazard ratio 0.91; 95% CI 0.85-0.98; P = 0.013)...
  44. doi Iron chelation treatment with deferasirox prior to high-dose chemotherapy and autologous stem cell transplantation may reduce the risk of hepatic veno-occlusive disease in children with high-risk solid tumors
    Hee Won Chueh
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul, Republic of Korea
    Pediatr Blood Cancer 58:441-7. 2012
    ....
  45. doi Telmisartan acts through the modulation of ACE-2/ANG 1-7/mas receptor in rats with dilated cardiomyopathy induced by experimental autoimmune myocarditis
    Vijayakumar Sukumaran
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Life Sci 90:289-300. 2012
    ..We investigated the cardioprotective effects of telmisartan in rats with dilated cardiomyopathy [DCM] after experimental autoimmune myocarditis [EAM]...
  46. ncbi Angiotensin II receptor blockers downsize adipocytes in spontaneously type 2 diabetic rats with visceral fat obesity
    Yutaka Mori
    Department of Internal Medicine, National Hospital Organization, Utsunomiya National Hospital, Kawachi gun, Tochigi, Japan
    Am J Hypertens 20:431-6. 2007
    ....
  47. ncbi Telmisartan improves vascular function and reduces platelet activation in rats with streptozotocin-induced diabetes mellitus
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Pharmacol Res 56:217-23. 2007
    ..Telmisartan normalizes vascular dysfunction and reduces platelet activation in diabetic rats. These effects may contribute to the reduction of cardiovascular events by angiotensin II receptor blockers in diabetic patients...
  48. ncbi Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase
    Peter Schmidt
    Institute of Cardiovascular Research, Bayer AG, Aprather Weg 18a, D 42096, Wuppertal, Germany
    Eur J Pharmacol 468:167-74. 2003
    ..These results show the different activation patterns of both compounds and demonstrate their value as tools to investigate the mechanisms that underlie soluble guanylyl cyclase activation...
  49. doi Telmisartan increases fatty acid oxidation in skeletal muscle through a peroxisome proliferator-activated receptor-gamma dependent pathway
    Ken Sugimoto
    Department of Laboratory Medicine, University of California, San Francisco, CA, USA
    J Hypertens 26:1209-15. 2008
    ..As muscle fatty acid oxidation is a major determinant of energy expenditure, we investigated the effects of telmisartan on skeletal muscle fatty acid oxidation in a rat model of the metabolic syndrome...
  50. doi BAY 58-2667, a nitric oxide-independent guanylyl cyclase activator, pharmacologically post-conditions rabbit and rat hearts
    Thomas Krieg
    Department of Cardiology, Ernst Moritz Arndt University, Loefflerstr 23, 17487 Greifswald, Germany
    Eur Heart J 30:1607-13. 2009
    ..We tested whether BAY-58 could make both rabbit and rat hearts resistant to infarction when given at the end of an ischaemic insult...
  51. pmc Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists
    Da Zhi Liu
    Department of Pharmacology, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Pudong, Shanghai 201203, China
    Br J Pharmacol 146:604-11. 2005
    ..However, PF had no 'well-known' cardiovascular side effects of classical A1R agonists. The results suggest that PF might have the potential therapeutic value as an anti-stroke drug...
  52. ncbi Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats
    Liang Xiao
    Department of Pharmacology, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang, Shanghai 201203, China
    Life Sci 78:413-20. 2005
    ..Transient MCAO also induced impairments in TP and performance in the water maze. Treatment with PF was able to reverse or alleviate these impairments. These results indicate that PF may be effective for treatment of stroke...
  53. ncbi Synthetic LXR agonists increase LDL in CETP species
    Pieter H E Groot
    Cardiovascular Center for Excellence in Drug Discovery, GlaxoSmithKline, King of Prussia, Pa 19406 0939, USA
    J Lipid Res 46:2182-91. 2005
    ..These results reveal additional problems associated with current synthetic LXR agonists and emphasize the importance of profiling compounds in preclinical species with a more human-like LXR response and lipoprotein metabolism...
  54. ncbi Raising HDL cholesterol without inducing hepatic steatosis and hypertriglyceridemia by a selective LXR modulator
    Bowman Miao
    Cardiovascular Biology, Bristol Myers Squibb Company, Experimental Station, Wilmington, DE 19880, USA
    J Lipid Res 45:1410-7. 2004
    ..This demonstration that tissue and gene selective modulation is possible with selective LXR modulators has positive implications for the development of this class of antiatherosclerotic agents...
  55. ncbi Comparison of telmisartan versus losartan: meta-analysis of titration-to-response studies
    David H G Smith
    Blood Press Monit 8:111-7. 2003
    ....
  56. ncbi Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity
    Michael Schupp
    Center for Cardiovascular Research, Institut fur Pharmakologie und Toxikologie, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Circulation 109:2054-7. 2004
    ..The peroxisome proliferator-activated receptor-gamma (PPARgamma) is the central regulator of insulin and glucose metabolism improving insulin sensitivity. We investigated the regulation of PPARgamma function by ARBs...
  57. doi Liver-specific peroxisome proliferator-activated receptor alpha target gene regulation by the angiotensin type 1 receptor blocker telmisartan
    Markus Clemenz
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Str 3 4, 10115 Berlin, Germany
    Diabetes 57:1405-13. 2008
    ..Activation of the PPARalpha ligand binding domain (LBD) was investigated using transactivation assays...
  58. ncbi Angiotensin II-induced stimulation of collagen secretion and production in cardiac fibroblasts is mediated via angiotensin II subtype 1 receptors
    P J Lijnen
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Leuven, Belgium
    J Renin Angiotensin Aldosterone Syst 2:117-22. 2001
    ....
  59. doi Telmisartan attenuates oxidative stress and renal fibrosis in streptozotocin induced diabetic mice with the alteration of angiotensin-(1-7) mas receptor expression associated with its PPAR-γ agonist action
    Arun Prasath Lakshmanan
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Free Radic Res 45:575-84. 2011
    ..These findings suggest that Ang-II plays a significant role in DN and telmisartan would be beneficial in reducing oxidative stress and fibrosis in STZ-induced DN...
  60. ncbi Isolation and characterization of novel benzoates, cinnamates, flavonoids, and lignans from Riesling wine and screening for antioxidant activity
    B Baderschneider
    , Schleinitzstrasse 20, DE-38106 Braunschweig, Germany
    J Agric Food Chem 49:2788-98. 2001
    ..Structural elucidation of the newly isolated wine constituents is reported together with the determination of their antioxidant activity...
  61. pmc Selective partial agonism of liver X receptor alpha is related to differential corepressor recruitment
    Caroline A Phelan
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Endocrinol 22:2241-9. 2008
    ..Thus, differential recruitment of NCoR is a major determinant of partial agonism and selective LXR modulation of target genes...
  62. ncbi A prospective, randomized, open-label trial comparing telmisartan 80 mg with valsartan 80 mg in patients with mild to moderate hypertension using ambulatory blood pressure monitoring
    T Littlejohn
    Piedmont Research Association, 1901 S Hawthorne Road, Winston Salem, SC 27103, USA
    Can J Cardiol 16:1123-32. 2000
    ..To compare the antihypertensive efficacy and tolerability of telmisartan 80 mg with valsartan 80 mg throughout a 24 h dosing interval...
  63. ncbi Effects of the angiotensin II receptor blockers telmisartan versus valsartan on the circadian variation of blood pressure: impact on the early morning period
    William B White
    Section of Hypertension and Clinical Pharmacology, University of Connecticut School of Medicine, Farmington, Connecticut 06032, USA
    Am J Hypertens 17:347-53. 2004
    ....
  64. ncbi Constrictor and dilator effects of angiotensin II on cerebral arterioles
    Jean Martin Vincent
    Laboratoire de Pharmacologie, Faculte de Pharmacie, l Université Henri Poincaré Nancy I, 5 rue Albert Lebrun, 54000 Nancy, France
    Stroke 36:2691-5. 2005
    ..In light of the equivocal data on the cerebral vasoconstrictor and vasodilator actions of angiotensin II (Ang II) and the potential clinical importance of this, we investigated the effects of Ang II on rat pial arterioles...
  65. doi Molecular cloning and functional characterization of the genes encoding benzoate and p-hydroxybenzoate degradation by the halophilic Chromohalobacter sp. strain HS-2
    Dockyu Kim
    Department of Environmental Engineering, BK21 Team for Biohydrogen Production, Chosun University, Gwangju, Korea
    FEMS Microbiol Lett 280:235-41. 2008
    ..When expressed in Escherichia coli, benzoate 1,2-dioxygenase (BenABC) and p-hydroxybenzoate hydroxylase (PobA) transformed benzoate and p-hydroxybenzoate into cis-benzoate dihydrodiol and protocatechuate, respectively...
  66. doi Telmisartan ameliorates experimental autoimmune myocarditis associated with inhibition of inflammation and oxidative stress
    Vijayakumar Sukumaran
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Eur J Pharmacol 652:126-35. 2011
    ....
  67. doi Telmisartan, an angiotensin-II receptor blocker ameliorates cardiac remodeling in rats with dilated cardiomyopathy
    Vijayakumar Sukumaran
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Hypertens Res 33:695-702. 2010
    ..Our results indicate that telmisartan treatment significantly improved LV function and ameliorated the progression of cardiac remodeling in rats with CHF after EAM...
  68. doi Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue
    Hiroshi Kudo
    Third Department of Internal Medicine, University of Toyama, Toyama, Japan
    Liver Int 29:988-96. 2009
    ..The aim of this study was to investigate the efficacy and mechanisms of Tel on a murine NASH model...
  69. ncbi [An experimental study of expression of angiotension converting enzyme 2 in myocardium and effect of telmisartan treatment in pressure-overloaded rats]
    Li Jun Wang
    Department of Cardiology, The Affiliated Baoan Hospital of Nanfang Medical University, Shenzhen 518101, Guangdong, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 20:218-22. 2008
    ..To study the effect of hypertension and telmisartan treatment on the protein and gene expression of cardiac angiotensin-converting enzyme 2 (ACE2) in pressure-overloaded rats...
  70. ncbi Telmisartan prevents hepatic fibrosis and enzyme-altered lesions in liver cirrhosis rat induced by a choline-deficient L-amino acid-defined diet
    Haiyan Jin
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1 1 1 Ube, Yamaguchi 755 8505, Japan
    Biochem Biophys Res Commun 364:801-7. 2007
    ..Tel inhibited HSCs activation and proliferation. These results suggested that Tel could be a promising drug for NASH related liver fibrosis...
  71. ncbi Prevention of transition from incipient to overt nephropathy with telmisartan in patients with type 2 diabetes
    Hirofumi Makino
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 Okayama, Japan
    Diabetes Care 30:1577-8. 2007
  72. pmc Arabidopsis GH3.12 (PBS3) conjugates amino acids to 4-substituted benzoates and is inhibited by salicylate
    Rachel A Okrent
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 3102, USA
    J Biol Chem 284:9742-54. 2009
    ..We found PBS3 favors 4-substituted benzoates such as 4-aminobenzoate and 4-hydroxybenzoate, with moderate activity on benzoate and no observed activity with ..
  73. ncbi Neuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation
    Toshihide Kurihara
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 47:5545-52. 2006
    ..To investigate the retinal neural damage that occurs during inflammation and the therapeutic effects of the angiotensin II type 1 receptor (AT1R) blocker, telmisartan, using a model of endotoxin-induced uveitis (EIU)...
  74. ncbi Telmisartan plus HCTZ vs. amlodipine plus HCTZ in older patients with systolic hypertension: results from a large ambulatory blood pressure monitoring study
    Steen Neldam
    Rodøvre Centrum, Denmark
    Am J Geriatr Cardiol 15:151-60. 2006
    ..0175). Adverse events (41.2% and 53.7%, respectively) and discontinuations (5.0% and 11.3%, respectively) were lower (p<0.0001) with telmisartan than with amlodipine, mainly due to peripheral edema (1.2% and 24.3%, respectively)...
  75. doi Cardioprotective mechanism of telmisartan via PPAR-gamma-eNOS pathway in dahl salt-sensitive hypertensive rats
    Naohiko Kobayashi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan
    Am J Hypertens 21:576-81. 2008
    ....
  76. doi Telmisartan is more effective than losartan in reducing proteinuria in patients with diabetic nephropathy
    George Bakris
    Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    Kidney Int 74:364-9. 2008
    ..We conclude that telmisartan is superior to losartan in reducing proteinuria in hypertensive patients with diabetic nephropathy, despite a similar reduction in blood pressure...
  77. ncbi A multicenter, 14-week study of telmisartan and ramipril in patients with mild-to-moderate hypertension using ambulatory blood pressure monitoring
    Yves Lacourciere
    Hypertension Research Unit, CHUL, Centre Hospitalier Universitaire de Quebec, 2705 boulevard Laurier S 135, Sainte Foy, Quebec, QC G1V 4G2, Canada
    Am J Hypertens 19:104-12. 2006
    ....
  78. ncbi ADMA and oxidative stress may relate to the progression of renal disease: rationale and design of the VIVALDI study
    Rainer H Boger
    Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg Eppendorf, Germany
    Vasc Med 10:S97-102. 2005
    ....
  79. ncbi Telmisartan: a review of its use in the management of hypertension
    Anna J Battershill
    Adis International Limited, Auckland, New Zealand
    Drugs 66:51-83. 2006
    ....
  80. ncbi Potential utility of telmisartan, an angiotensin II type 1 receptor blocker with peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-modulating activity for the treatment of cardiometabolic disorders
    Sho ichi Yamagishi
    Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Curr Mol Med 7:463-9. 2007
    ..In this paper, we reviewed the potential utility of telmisartan in insulin resistance and vascular complications in diabetes...
  81. doi Effects of telmisartan, ramipril, and their combination on left ventricular hypertrophy in individuals at high vascular risk in the Ongoing Telmisartan Alone and in Combination With Ramipril Global End Point Trial and the Telmisartan Randomized Assessment
    Paolo Verdecchia
    McMaster University, Population Health Research Institute, 237 Barton St E, Hamilton, ON L8L2X2 Canada
    Circulation 120:1380-9. 2009
    ..Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers reduce left ventricular hypertrophy (LVH). The effect of these drugs on LVH in high-risk patients without heart failure is unknown...
  82. ncbi Interaction between glutamatergic and nitrergic mechanisms mediating cardiovascular responses to L-glutamate injection in the diagonal band of Broca in anesthetized rats
    Rodrigo Fiacadori Tavares
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Av Bandeirantes, 3900, CEP 14090 090, Brazil
    Life Sci 81:855-62. 2007
    ..These results suggest that the microinjection of L-glu into the dbB of urethane-anesthetized rats causes dose-related depressor and bradycardiac responses through the NMDA receptor-NO-guanylate cyclase pathway...
  83. ncbi Study of factors which negatively affect expression of the phenol degradation operon pheBA in Pseudomonas putida
    Marta Putrins
    Department of Genetics, Institute of Molecular and Cell Biology, Tartu University and Estonian Biocentre, 51010 Tartu, Estonia
    Microbiology 153:1860-71. 2007
    ....
  84. ncbi Characterization of anaerobic catabolism of p-coumarate in Rhodopseudomonas palustris by integrating transcriptomics and quantitative proteomics
    Chongle Pan
    Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA
    Mol Cell Proteomics 7:938-48. 2008
    ..The integrated gene expression data provided strong support for the non-beta-oxidation route in R. palustris. A putative gene was proposed for every step in the non-beta-oxidation route...
  85. pmc The target for the Pseudomonas putida Crc global regulator in the benzoate degradation pathway is the BenR transcriptional regulator
    Renata Moreno
    Departamento de Biotecnologia Microbiana, Centro Nacional de Biotecnologia, CSIC, Campus de la Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Bacteriol 190:1539-45. 2008
    ....
  86. ncbi Telmisartan inhibits CD4-positive lymphocyte migration independent of the angiotensin type 1 receptor via peroxisome proliferator-activated receptor-gamma
    Daniel Walcher
    Department of Internal Medicine II Cardiology, University of Ulm, Robert Koch Str 8, D 89081 Ulm, Germany
    Hypertension 51:259-66. 2008
    ..These data provide a novel mechanism to explain how telmisartan modulates lymphocyte activation by its PPARgamma-activating properties...
  87. doi Effects of the angiotensin II receptor blockers telmisartan versus valsartan in combination with hydrochlorothiazide: a large, confirmatory trial
    William B White
    Division of Hypertension and Clinical Pharmacology, Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Blood Press Monit 13:21-7. 2008
    ..Both studies support the strategy of using angiotensin receptor blockers with a higher dose of a thazide diuretic (25 mg) for enhancing the control of hypertension...
  88. ncbi Combination treatment with telmisartan and hydrochlorothiazide in black patients with mild to moderate hypertension
    J B McGill
    Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Clin Cardiol 24:66-72. 2001
    ..CONCLUSIONS: Telmisartan 80 mg combined with HCTZ 12.5 mg is effective and well tolerated in black patients with mild to moderate hypertension, providing greater antihypertensive activity than the corresponding monotherapies...
  89. ncbi Are the pleiotropic effects of telmisartan clinically relevant?
    C V Rizos
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    Curr Pharm Des 15:2815-32. 2009
    ..However, do all these pleiotropic effects translate into clinical benefit? Recent studies have tried to answer this question with promising but not definitive results...
  90. pmc BadM is a transcriptional repressor and one of three regulators that control benzoyl coenzyme A reductase gene expression in Rhodopseudomonas palustris
    Caroline M Peres
    Department of Microbiology, Box 357242, 1959 N E Pacific Street, University of Washington, Seattle, WA 98195 7242, USA
    J Bacteriol 188:8662-5. 2006
    ..BadM controls gene expression from the benzoyl-CoA reductase promoter in concert with two previously described transcriptional activators...
  91. pmc Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFE
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Lancet Neurol 7:875-84. 2008
    ..The putative neuroprotective effects of antiplatelet compounds and the angiotensin II receptor antagonist telmisartan were investigated in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial...
  92. doi Production and secretion of adiponectin from 3T3-L1 adipocytes: comparison of antihypertensive drugs
    Raphaelle Brody
    Hypertension Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Am J Hypertens 22:1126-9. 2009
    ..The aim of this study was to evaluate the effect of various antihypertensive drugs on the production and secretion of adiponectin from adipocytes...
  93. ncbi Telmisartan improves insulin sensitivity in nondiabetic patients with essential hypertension
    Ralf A Benndorf
    Department of Clinical Pharmacology, Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital Hamburg Eppendorf, D 20246 Hamburg, Germany
    Metabolism 55:1159-64. 2006
    ..Future studies will demonstrate whether these telmisartan-induced effects may contribute to a blood pressure-independent reduction in cardiovascular morbidity...
  94. ncbi Measuring the efficacy of antihypertensive therapy by ambulatory blood pressure monitoring in the primary care setting
    William B White
    Division of Hypertension and Clinical Pharmacology, Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, Farmington, CT, USA
    Am Heart J 151:176-84. 2006
    ..Therefore, we used ambulatory blood pressure monitoring (ABPM), an automated and objective measure of blood pressure (BP) to overcome these shortcomings in a large community-based trial...
  95. ncbi Telmisartan/Hydrochlorothiazide in comparison with losartan/hydrochlorothiazide in managing patients with mild-to-moderate hypertension
    Joel M Neutel
    Orange County Research Center, Tustin, USA
    Hypertens Res 28:555-63. 2005
    ..5 during the last 6 h of the 24-h dosing interval, which corresponds to the high-risk early-morning hours, and that T80/H12.5 provided additional blood pressure reductions...
  96. ncbi Effects of the angiotensin II receptor blockers telmisartan vs valsartan in combination with hydrochlorothiazide 25 mg once daily for the treatment of hypertension
    William B White
    Division of Hypertension and Clinical Pharmacology, Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, Farmington, CT 06030 3940, USA
    J Clin Hypertens (Greenwich) 8:626-33. 2006
    ..These data support using a higher dose of a thiazide diuretic (25 mg) with a long-acting angiotensin receptor blocker as a useful strategy for improving hypertension control...
  97. ncbi Inhibitory effect of telmisartan on the blood pressure response to angiotensin II challenge
    J Stangier
    Boehringer Ingelheim Pharma KG, Biberach, Germany, and Pharma Bio-Research International B.V, Zuidlaren, The Netherlands
    J Cardiovasc Pharmacol 38:672-85. 2001
    ..In conclusion, telmisartan 40 mg provides rapid-onset, well-tolerated, and near-maximal inhibition of angiotensin II-induced hypertension, with maintenance of the inhibitory effect for 48 h...
  98. ncbi Telmisartan has the strongest binding affinity to angiotensin II type 1 receptor: comparison with other angiotensin II type 1 receptor blockers
    H Kakuta
    Pharmacology Laboratory, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba, Japan
    Int J Clin Pharmacol Res 25:41-6. 2005
    ..The present findings suggest that telmisartan (Micardis) may have long-lasting blood pressure-lowering effects and superior cardioprotective properties in patients with hypertension due to its strongest AT1 receptor antagonistic ability...
  99. ncbi Effect of telmisartan on the proteinuria and circadian blood pressure profile in chronic renal patients
    Adamasco Cupisti
    Nephrology Unit, Department of Internal Medicine, University of Pisa, Via Roma 67, 56100, Pisa, Italy
    Biomed Pharmacother 57:169-72. 2003
    ....
  100. ncbi Angiotensin II stimulates platelet-derived growth factor-B gene expression in cultured retinal pericytes through intracellular reactive oxygen species generation
    S Amano
    Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Int J Tissue React 25:51-5. 2003
    ....
  101. ncbi The pimFABCDE operon from Rhodopseudomonas palustris mediates dicarboxylic acid degradation and participates in anaerobic benzoate degradation
    Faith H Harrison
    Department of Microbiology, The University of Iowa, 3 450 BSB, Iowa City, IA 52242, USA
    Microbiology 151:727-36. 2005
    ..However, the finding that the pim operon deletion mutant is still able to grow on dicarboxylic acids, albeit at a slower rate, indicates that R. palustris has additional genes that can also specify the degradation of these compounds...

Research Grants125 found, 100 shown here

  1. OCULAR DISPOSITION OF ACYCLOGUANOSINE ANALOGUES
    Ashim Mitra; Fiscal Year: 2001
    ..2) branched chain aliphatic esters: pivaloate, isobutyrate, 3) aromatic esters: benzoate, p- methoxy, p-nitro benzoates and 4) alicyclic ester: 1-adamantoate...
  2. OCULAR DISPOSITION OF ACYCLOGUANOSINE ANALOGUES
    Ashim Mitra; Fiscal Year: 1999
    ..2) branched chain aliphatic esters: pivaloate, isobutyrate, 3) aromatic esters: benzoate, p methoxy, p-nitro benzoates and 4) alicyclic ester: 1-adamantoate...
  3. ASTATINE AND IODINE RADIOLABELED MONOCLONAL ANTIBODIES
    Michael Rod Zalutsky; Fiscal Year: 2010
    ..Our studies revealed that radio iodination of anti-EGFRvIII mAbs using reagents containing benzoates bearing charged substituent's or D-amino acid peptides significantly improved retention of radioactivity in ..
  4. BXR SIGNALING IN VERTEBRATE DEVELOPMENT
    Bruce Blumberg; Fiscal Year: 2004
    ..isolated and characterized a novel nuclear receptor activated by a class of endogenous substituted alkyl benzoates. These compounds comprise a novel class of hormone receptor ligand and are related the B-complex vitamins p-..
  5. Contingency Management for Initiating Smoking Abstinence
    William White; Fiscal Year: 2009
    ..Clinic and 24-hour blood pressure (BP) and heart rate (HR) will be additional outcomes. We expect that BP and HR will decrease more among CM than non-CM patients and reductions in smoking may mediate decreases in these indices. ..
  6. Contingency Management for Initiating Smoking Abstinence
    WILLIAM BARRY WHITE; Fiscal Year: 2010
    ..Clinic and 24-hour blood pressure (BP) and heart rate (HR) will be additional outcomes. We expect that BP and HR will decrease more among CM than non-CM patients and reductions in smoking may mediate decreases in these indices. ..
  7. Mechanisms of Als vaccine protection against S. aureus
    Brad Spellberg; Fiscal Year: 2009
    ..The insights into fundamental immunological mechanisms of protection against S. aureus will also be of extreme importance to the development of other vaccine candidates targeting S. aureus in the future. ..
  8. Mechanisms of Als vaccine protection against S. aureus
    Brad Spellberg; Fiscal Year: 2007
    ..The insights into fundamental immunological mechanisms of protection against S. aureus will also be of extreme importance to the development of other vaccine candidates targeting S. aureus in the future. ..
  9. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  10. Activated Targeted Killer (ATAK) Cells for Invasive Fungal Infections
    Brad J Spellberg; Fiscal Year: 2010
    ..Completion of the proposed studies will enable us to create a safe and effective strategy to overcome the barriers to white blood cell transfusions, revolutionizing the treatment of infections in cancer patients. ..
  11. Activated Targeted Killer (ATAK) Cells for Invasive Fungal Infections
    Brad Spellberg; Fiscal Year: 2009
    ..Completion of the proposed studies will enable us to create a safe and effective strategy to overcome the barriers to white blood cell transfusions, revolutionizing the treatment of infections in cancer patients. ..
  12. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad Spellberg; Fiscal Year: 2009
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  13. Mechanisms of Als vaccine protection against S. aureus
    Brad J Spellberg; Fiscal Year: 2010
    ..The insights into fundamental immunological mechanisms of protection against S. aureus will also be of extreme importance to the development of other vaccine candidates targeting S. aureus in the future. ..
  14. Adrenergic Antagonism During Murine Candidiasis
    Brad Spellberg; Fiscal Year: 2007
    ..For these reasons, the potential for adrenergic antagonism to act as an effective immunotherapy is highly meritorious of investigation in this training application. ..
  15. E/BETA THALASSEMIA--NATURAL HISTORY & RESPONSE TO CHEMO
    Elliott Vichinsky; Fiscal Year: 2002
    ..In summary, if this study is successful, it will change the approach to Hb E/B worldwide and result in improved quality of life and decreased mortality. (End of Abstract) ..
  16. SECONDARY HEMOCHROMATOSIS IN BETA THALASSEMIA AND SCD
    Elliott Vichinsky; Fiscal Year: 2004
    ....
  17. THALASSEMIA CLINICAL RESEARCH NETWORK
    Elliott Vichinsky; Fiscal Year: 2007
    ....
  18. Eighth Cooley's Anemia Symposium
    Elliott Vichinsky; Fiscal Year: 2005
    ....
  19. REMINERALIZING PULP-CAPPING CEMENTS & BONDING AGENTS
    SABINE DICKENS; Fiscal Year: 2003
    ..The proposed studies will also provide a valuable comparison of in vivo test results to pulp cell response in vitro. ..
  20. IMPROVED PREVENTIVE/RESTORATIVE RESINS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2006
    ..The data gathered in these experiments will serve to support a larger R01 grant application with the long-term objectives of developing improved durable materials for adhesives and adhesive composites. ..
  21. NEW EXPERIMENTAL MODELS OF HYPERTENSION
    Theodore Kurtz; Fiscal Year: 2006
    ..Hypertension candidate genes will then be isolated using cDNA screening techniques to identify genes expressed in the brain, adrenal gland, or kidney that map within this chromosome region. ..
  22. Imaging of O6-Alkylguanine-DNA Alkyltransferase
    Ganesan Vaidyanathan; Fiscal Year: 2005
    ..In summary, this proposal seeks to determine whether the development of a suitable agent for the imaging of tumor AGT will facilitate chemotherapy planning, thereby improving the outcome of alkylator chemotherapy. ..
  23. NEW EXPERIMENTAL MODELS OF HYPERTENSION
    Theodore Kurtz; Fiscal Year: 2001
    ..Finally, they will distribute these strains to other investigators also interested in studying pathophysiologic mechanisms whereby selected chromosome regions may influence cardiovascular function and BP. ..
  24. RESIN-BASED REMINERALIZING CEMENTS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2009
    ..Completion of this research will lead to Ca- PO4 cements and composites with improved adhesion to dentin and improved strength for ART and the treatment of root caries. ..
  25. KIDNEY SPECIFIC GENE TRANSFER IN HYPERTENSION
    Theodore Kurtz; Fiscal Year: 1999
    ....
  26. MIBG ANALOGUE RADIOPHARMACEUTICALS
    Ganesan Vaidyanathan; Fiscal Year: 2001
    ..Strategies to augment tumor-to-normal tissue ratios will be investigated. The outcome of this study should help improve the endoradiotherapy of neuroendocrine tumors and possibly of medulloblastoma. ..
  27. KIDNEY SPECIFIC GENE TRANSFER IN HYPERTENSION
    Theodore Kurtz; Fiscal Year: 2003
    ..Under this alternative hypothesis, the results of the cDNA microarray analysis will be used to identify potential downstream target genes whose expression is altered by the primary genetic defect on chromosome 1. ..
  28. NEW EXPERIMENTAL MODELS OF HYPERTENSION
    Theodore W Kurtz; Fiscal Year: 2010
    ..This project is designed to investigate genetic factors that influence the development of the metabolic syndrome and ultimately help identify new targets for prevention and treatment of diabetes and cardiovascular disease. ..
  29. WHY DO METABOLIC RISK FACTORS CLUSTER WITH HYPERTENSION?
    Theodore Kurtz; Fiscal Year: 2003
    ....
  30. Flavoenzymes in Pyrimidine Metabolism
    Bruce A Palfey; Fiscal Year: 2010
    ..Our studies of the rates of the chemical reactions will identify important parts of the proteins, how they move during reactions, how they speed the synthesis of products, and how these reactions might be blocked. ..
  31. Bisphenol A and Phthalate Exposure in Relation to Fetal Growth and Preterm Birth
    John D Meeker; Fiscal Year: 2010
    ....
  32. TGF-beta and axis formation in Helobdella, a lophotrochozoan
    David A Weisblat; Fiscal Year: 2010
    ..They will also contribute to understanding the cellular processes known as epithelial-to-mesenchymal transitions (EMTs), which play a critical role both in normal development and in cancer metastasis. ..
  33. TGF-beta and axis formation in Helobdella, a lophotrochozoan
    DAVID WEISBLAT; Fiscal Year: 2007
    ..They will also contribute to understanding the cellular processes known as epithelial-to-mesenchymal transitions (EMTs), which play a critical role both in normal development and in cancer metastasis. ..
  34. ANALYSIS OF PAIR OF RULE GENES IN SEQUENTIAL SEGMENTATIO
    DAVID WEISBLAT; Fiscal Year: 2003
    ..abstract_text> ..
  35. MECHANISMS FOR ALTERED SYNAPTIC FUNCTION DURING AGING
    Thomas Foster; Fiscal Year: 2000
    ..The results of these experiments will add significantly to our knowledge of mechanisms for regulation of synaptic function across the life span and provide a basis for understanding the role of synaptic plasticity in cognitive function. ..