mefenamic acid

Summary

Summary: A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.

Top Publications

  1. ncbi Acyl glucuronidation of fluoroquinolone antibiotics by the UDP-glucuronosyltransferase 1A subfamily in human liver microsomes
    Masaya Tachibana
    Department of Biopharmaeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Drug Metab Dispos 33:803-11. 2005
  2. ncbi Occurrence of several acidic drugs in sewage treatment plants in Switzerland and risk assessment
    A Tauxe-Wuersch
    Ecole Polytechnique Federale de Lausanne EPFL, Laboratory of Environmental Chemistry and Ecotoxicology, CH 1015 Lausanne, Switzerland
    Water Res 39:1761-72. 2005
  3. ncbi The occurrence and removal of selected pharmaceutical compounds in a sewage treatment works utilising activated sludge treatment
    O A H Jones
    Institute of Environmental Policy, Imperial College, London SW7 2AZ, UK
    Environ Pollut 145:738-44. 2007
  4. ncbi Glucuronidation of fenamates: kinetic studies using human kidney cortical microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7
    Paraskevi Gaganis
    Department of Clinical Pharmacology, Flinders University and Flinders Medical Centre, Bedford Park, Adelaide, Australia
    Biochem Pharmacol 73:1683-91. 2007
  5. ncbi Sodium mefenamate as a solution for the formulation and dissolution problems of mefenamic acid
    Ahmad Bani-Jaber
    College of Pharmacy, Jordan University, Amman, Jordan
    Chem Pharm Bull (Tokyo) 55:1136-40. 2007
  6. ncbi Stabilization of a supersaturated solution of mefenamic acid from a solid dispersion with EUDRAGIT(®) EPO
    Taro Kojima
    Chiba University, Chiba, Japan
    Pharm Res 29:2777-91. 2012
  7. pmc Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid
    Jeffery J Prusakiewicz
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 48:7353-5. 2009
  8. ncbi Liver injury induced by the non-steroidal anti-inflammatory drug mefenamic acid
    N Somchit
    Pharmacology and Toxicology Unit, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia
    Singapore Med J 45:530-2. 2004
  9. ncbi Indirect chemiluminescence-based detection of mefenamic acid in pharmaceutical formulations by flow injection analysis and effect of gold nanocatalysts
    Evangelos G Zisimopoulos
    Laboratory of Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
    Talanta 79:893-9. 2009
  10. ncbi Randomised comparative trial of the levonorgestrel intrauterine system and mefenamic acid for the treatment of idiopathic menorrhagia: a multiple analysis using total menstrual fluid loss, menstrual blood loss and pictorial blood loss assessment charts
    Peter C Reid
    Luton and Dunstable NHS Trust, Luton, UK
    BJOG 112:1121-5. 2005

Detail Information

Publications209 found, 100 shown here

  1. ncbi Acyl glucuronidation of fluoroquinolone antibiotics by the UDP-glucuronosyltransferase 1A subfamily in human liver microsomes
    Masaya Tachibana
    Department of Biopharmaeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Drug Metab Dispos 33:803-11. 2005
    ..9 microM and 4.7 microM, respectively; in contrast, the glucuronidation activity of GPFX was inhibited by mefenamic acid with an IC50 value of 9.8 microM...
  2. ncbi Occurrence of several acidic drugs in sewage treatment plants in Switzerland and risk assessment
    A Tauxe-Wuersch
    Ecole Polytechnique Federale de Lausanne EPFL, Laboratory of Environmental Chemistry and Ecotoxicology, CH 1015 Lausanne, Switzerland
    Water Res 39:1761-72. 2005
    The occurrence and fate of five acidic drugs (Mefenamic acid, Ibuprofen, Ketoprofen, Diclofenac and Clofibric acid) were analysed in three sewage treatment plants (STP) over 4-7 consecutive days...
  3. ncbi The occurrence and removal of selected pharmaceutical compounds in a sewage treatment works utilising activated sludge treatment
    O A H Jones
    Institute of Environmental Policy, Imperial College, London SW7 2AZ, UK
    Environ Pollut 145:738-44. 2007
    ..The results demonstrate that ibuprofen, paracetamol, salbutamol and mefenamic acid were present in both the influent and effluent of the works while propranolol-HCl was not found above the ..
  4. ncbi Glucuronidation of fenamates: kinetic studies using human kidney cortical microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7
    Paraskevi Gaganis
    Department of Clinical Pharmacology, Flinders University and Flinders Medical Centre, Bedford Park, Adelaide, Australia
    Biochem Pharmacol 73:1683-91. 2007
    b>Mefenamic acid, a non-steroidal anti-inflammatory drug (NSAID), is used commonly to treat menorrhagia...
  5. ncbi Sodium mefenamate as a solution for the formulation and dissolution problems of mefenamic acid
    Ahmad Bani-Jaber
    College of Pharmacy, Jordan University, Amman, Jordan
    Chem Pharm Bull (Tokyo) 55:1136-40. 2007
    Sodium salt formation of mefenamic acid (MA) was studied as a way to solve the formulation and dissolution problems of MA...
  6. ncbi Stabilization of a supersaturated solution of mefenamic acid from a solid dispersion with EUDRAGIT(®) EPO
    Taro Kojima
    Chiba University, Chiba, Japan
    Pharm Res 29:2777-91. 2012
    The stabilization mechanism of a supersaturated solution of mefenamic acid (MFA) from a solid dispersion with EUDRAGIT(®) EPO (EPO) was investigated.
  7. pmc Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid
    Jeffery J Prusakiewicz
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 48:7353-5. 2009
    Ibuprofen and mefenamic acid are weak, competitive inhibitors of cyclooxygenase-2 (COX-2) oxygenation of arachidonic acid (AA) but potent, noncompetitive inhibitors of 2-arachidonoylglycerol (2-AG) oxygenation...
  8. ncbi Liver injury induced by the non-steroidal anti-inflammatory drug mefenamic acid
    N Somchit
    Pharmacology and Toxicology Unit, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia
    Singapore Med J 45:530-2. 2004
    ..Virtually all NSAIDs are capable of producing liver injury ranging from mild reversible elevation of liver enzymes to severe hepatic necrosis...
  9. ncbi Indirect chemiluminescence-based detection of mefenamic acid in pharmaceutical formulations by flow injection analysis and effect of gold nanocatalysts
    Evangelos G Zisimopoulos
    Laboratory of Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
    Talanta 79:893-9. 2009
    ..FI-CL) method based on periodate oxidation of two popular luminescent compounds for the determination of mefenamic acid (MFA) is presented...
  10. ncbi Randomised comparative trial of the levonorgestrel intrauterine system and mefenamic acid for the treatment of idiopathic menorrhagia: a multiple analysis using total menstrual fluid loss, menstrual blood loss and pictorial blood loss assessment charts
    Peter C Reid
    Luton and Dunstable NHS Trust, Luton, UK
    BJOG 112:1121-5. 2005
    To compare the efficacy and tolerability of the levonorgestrel intrauterine system (LNG IUS) with mefenamic acid in the management of objective idiopathic menorrhagia.
  11. ncbi Evidence for neuroprotection by the fenamate NSAID, mefenamic acid
    Parto S Khansari
    University of the Pacific, Stockton, CA 95211, USA
    Neurochem Int 55:683-8. 2009
    ..The aim of this study was to investigate the hypothesis that the fenamate, mefenamic acid, is neuroprotective in an in vitro and in vivo model of stroke...
  12. pmc Fenamates as TRP channel blockers: mefenamic acid selectively blocks TRPM3
    Chihab Klose
    Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Interfaculty Center of Pharmacogenomics and Pharmaceutical Research ICePhA, Eberhard Karls University, Tubingen, Germany
    Br J Pharmacol 162:1757-69. 2011
    ..Reports describing fenamates as tools to interfere with cellular volume regulation attracted our attention based on our interest in the role of the volume-modulated transient receptor potential (TRP) channels TRPM3 and TRPV4...
  13. pmc Treatment of menorrhagia during menstruation: randomised controlled trial of ethamsylate, mefenamic acid, and tranexamic acid
    J Bonnar
    Trinity College, Department of Obstetrics and Gynaecology, St James Hospital, Dublin, Ireland
    BMJ 313:579-82. 1996
    To compare the efficacy and acceptability of ethamsylate, mefenamic acid, and tranexamic acid for treating menorrhagia.
  14. ncbi Kinetic study of the transformation of mefenamic acid polymorphs in various solvents and under high humidity conditions
    Fumie Kato
    Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashinada, Kobe 658 8558, Japan
    Int J Pharm 321:18-26. 2006
    The transformation kinetics of mefenamic acid form II to form I in three kinds of solvents and under high humidity conditions were extensively investigated...
  15. ncbi Physicochemical and crystallographic characterization of mefenamic acid complexes with alkanolamines
    Liang Fang
    Faculty of Pharmaceutial Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    J Pharm Sci 93:144-54. 2004
    The preparation of mefenamic acid (MH)-alkanolamine (propanolamine, diethanolamine, triethanolamine) complexes was attempted to increase the transdermal flux of MH...
  16. ncbi Protective role of vitamin E on mefenamic acid-induced alterations in erythrocytes
    I Ahmad
    Department of Biochemistry, University of Allahabad, Allahabad 211002, UP, India
    Biochemistry (Mosc) 67:945-8. 2002
    ..F.), acetylcholinesterase (AChE) activity, and the level of malonyl dialdehyde (MDA) of control, mefenamic acid treated, and mefenamic acid with vitamin E treated rats were investigated...
  17. ncbi Altered brain penetration of diclofenac and mefenamic acid, but not acetaminophen, in Shiga-like toxin II-treated mice
    Masaya Fukuda
    Department of Medical Technology, Nagoya University School of Health Sciences, Japan
    J Pharmacol Sci 97:525-32. 2005
    ..coli O157:H7, which significantly elevates cytokine levels. As antipyretics, we used diclofenac, mefenamic acid, and acetaminophen...
  18. ncbi Solid-state characterization of mefenamic acid
    Ramesh Panchagnula
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Phase 10, Sector 67, Mohali 160 062, Punjab, India
    J Pharm Sci 93:1019-29. 2004
    The purpose of this study was to characterize mefenamic acid (MA) from commercial samples and samples crystallized from different solvents...
  19. ncbi Comparison of the effectiveness of fennel and mefenamic acid on pain intensity in dysmenorrhoea
    V Modaress Nejad
    Department of Obstetrics and Gynaecology, Kerman University of Medial Sciences and Health Services, Kerman, Islamic Republic of Iran
    East Mediterr Health J 12:423-7. 2006
    A study in Kerman, Islamic Republic of Iran in 2002 compared the effectiveness of fennel and mefenamic acid on pain relief in primary dysmenorrhoea...
  20. pmc Mefenamic acid as a novel activator of L-type voltage-dependent Ca2+ channels in smooth muscle cells from pig proximal urethra
    Noriyoshi Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka 812 8582, Japan
    Br J Pharmacol 144:919-25. 2005
    The effects of mefenamic acid and Bay K 8644 on voltage-dependent nifedipine-sensitive inward Ba2+ currents in pig urethral myocytes were investigated by use of conventional whole-cell configuration patch clamp...
  21. ncbi Probing the permeation enhancement of mefenamic acid by ethanol across full-thickness skin, heat-separated epidermal membrane and heat-separated dermal membrane
    Charles M Heard
    Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, UK
    Int J Pharm 349:323-5. 2008
    The permeation enhancement of mefenamic acid by ethanol across full-thickness porcine skin, heat-separated epidermal membrane and heat-separated dermal membrane has been probed...
  22. ncbi Skin penetration enhancement of mefenamic acid by ethanol and 1,8-cineole can be explained by the 'pull' effect
    Charles M Heard
    Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, UK
    Int J Pharm 321:167-70. 2006
    ..Simple formulations of mefenamic acid in PEG400 incorporating various proportions of ethanol or 1,8-cineole were prepared and applied to porcine ear ..
  23. ncbi Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea
    Giti Ozgoli
    Nursing and Midwifery School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    J Altern Complement Med 15:129-32. 2009
    To compare the effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea.
  24. ncbi Glyceride derivatives as potential prodrugs: synthesis, biological activity and kinetic studies of glyceride derivatives of mefenamic acid
    M S Y Khan
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard Hamdard University, New Delhi, India
    Pharmazie 60:110-4. 2005
    In order to reduce the gastrointestinal side effect, of mefenamic acid, its carboxylic group was condensed with the hydroxyl group of 1,2,3-trihydroxy propane 1,3-dipalmitate/stearate to give 3a and 3b...
  25. ncbi Investigations on mefenamic acid sustained release tablets with water-insoluble gel
    S Gungor
    Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul University, 34452 Beyazit, Istanbul, Turkey
    Farmaco 58:397-401. 2003
    b>Mefenamic acid (MA) has analgesic, anti-inflammatory and antipyretic properties. Available conventional dosage forms are capsules and film-coated tablets. No commercial sustained release preparation of MA exists in the market...
  26. ncbi Simultaneous spectrophotometric determination of mefenamic acid and paracetamol in a pharmaceutical preparation using ratio spectra derivative spectrophotometry and chemometric methods
    Erdal Dinc
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Ankara, 06100 Tandogan, Ankara, Turkey
    J Pharm Biomed Anal 28:1091-100. 2002
    Four new methods are described for the simultaneous determination of mefenamic acid (MEF) and paracetamol (PAR) in their combination...
  27. ncbi Anti-oxidant, in vitro, in vivo anti-inflammatory activity and antiproliferative activity of mefenamic acid and its metal complexes with manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II)
    Dimitra Kovala-Demertzi
    Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45100, Ioannina, Greece
    J Enzyme Inhib Med Chem 24:742-52. 2009
    Some new complexes of mefenamic acid with potentially interesting biological activity are described...
  28. pmc Mefenamic acid-induced bilateral transient myopia, secondary angle closure glaucoma and choroidal detachment
    Parag Vishwakarma
    Glaucoma Services, Aravind Eye Hospital, Coimbatore 641014, India
    Indian J Ophthalmol 57:398-400. 2009
    ..We describe here a patient who presented with secondary angle closure glaucoma and myopia following mefenamic acid ingestion which was managed successfully by stopping the medication, symptomatic treatment and reassurance.
  29. ncbi [Acute renal failure--"a well meant present from a friend"]
    M A E Buylaert
    Medizinische Klinik B, Universitatsspital Basel
    Ther Umsch 61:725-7. 2004
    ..Patients do not mention ointments because they often do not realize that ointments contain active substances, and physicians forget to ask...
  30. ncbi [Mefenamic acid and other non-steroidal anti-inflammatory agents in dental practice. A review of the literature]
    André Rätzer Künzel
    Klinik für zahnärztliche Chirurgie, Radiologie, Mund und Kieferheilkunde der Universitätskliniken für Zahnmedizin, Basel
    Schweiz Monatsschr Zahnmed 117:12-8. 2007
    There are no studies verifying that mefenamic acid is more effective than other NSAID (= non-steroidal anti-inflammatory drugs)...
  31. ncbi Effect of mefenamic acid on controlling irregular uterine bleeding in DMPA users
    Pisit Tantiwattanakul
    Department of Obstetrics and Gynecology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok 10330, Thailand
    Contraception 70:277-9. 2004
    The objective of this double-blind, placebo-controlled study was to evaluate the effect of mefenamic acid and placebo on controlling irregular uterine bleeding in depot-medroxyprogesterone acetate (DMPA) users...
  32. ncbi Second-order calibration of excitation-emission matrix fluorescence spectra for the determination of N-phenylanthranilic acid derivatives
    A Muñoz de la Peña
    Departamento de Quimica Analitica, Facultad de Ciencias, Universidad de Extremadura, 06071, Badajoz, Espana
    Appl Spectrosc 60:330-8. 2006
    ..15 to 0.8 microg mL-1 for flufenamic and meclofenamic acids and from 0.25 to 3.0 microg mL-1 for mefenamic acid. The combination of chloroform extraction and second-order calibration methods, using the excitation-emission ..
  33. ncbi Predominant contribution of UDP-glucuronosyltransferase 2B7 in the glucuronidation of racemic flurbiprofen in the human liver
    Yuji Mano
    Drug Metabolism Research Laboratories, Astellas Pharma Inc, Itabashi ku, Tokyo, Japan
    Drug Metab Dispos 35:1182-7. 2007
    ..In addition, the formation of both glucuronides correlated significantly (r = 0.99, p < 0.0001). Mefenamic acid inhibited the formation of both (R)- and (S)-glucuronide in HLMs with similar IC(50) values (2.0 and 1...
  34. ncbi Randomized controlled trial of mefenamic acid vs paracervical block for relief of pain for outpatient uterine curettage
    Pranom Buppasiri
    Department of Ob Gyn, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002 Thailand
    J Med Assoc Thai 88:881-5. 2005
    To compare the efficacy of mefenamic acid vs paracervical block for pain relief during and after fractional curettage.
  35. ncbi Effects of aspirin and mefenamic acid on soman poisoning-induced neuropathology in mice
    Jean Marc Collombet
    Departement de Toxicologie, CRSSA, La Tronche, France
    Drug Chem Toxicol 29:167-81. 2006
    The efficacy of aspirin and mefenamic acid to counteract soman-induced brain damage was investigated in mice...
  36. ncbi Survival of severe amlodipine intoxication due to medical intensive care
    Susanne Vogt
    Institute of Forensic Medicine, University Hospital, Freiburg, Germany
    Forensic Sci Int 161:216-20. 2006
    We report the case of attempted suicide with amlodipine, chlorthalidone and mefenamic acid and subsequent medical intensive care measures which resulted in total recovery of a 42-year-old male...
  37. ncbi Renal humoral modulation of skeletal muscle tone in mice: implications for 'the pulmonary-renal cascade'
    Manoj G Tyagi
    Department of Pharmacology, Christian Medical College, Vellore 632 002
    Indian J Physiol Pharmacol 49:403-10. 2005
    ..e. inclined plane test, grip strength test and swim test. Groups of mice (n=6) were pre-treated with mefenamic acid (60 mg/kg, i.p), carbenoxolone (100 mg/kg i...
  38. ncbi Pediatric posterior reversible leukoencephalopathy syndrome and NSAID-induced acute tubular interstitial nephritis
    Shoji Yokobori
    Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan
    Pediatr Neurol 34:245-7. 2006
    ..A 10-year-old male was hit on his back, resulting in backache. He was medicated with sodium diclofenate and mefenamic acid. The next day, he had edema and oliguria...
  39. ncbi An anti-inflammatory drug (mefenamic acid) incorporated in biodegradable alginate beads: development and optimization of the process using factorial design
    Ferhan Sevgi
    Department of Pharmaceutical Technology, Faculty of Pharmacy, Ege University, Bornova, Izmir, Turkey
    Pharm Dev Technol 13:5-13. 2008
    ..prepare and evaluate biodegradable alginate beads as a controlled-release system for a water-insoluble drug, mefenamic acid (MA), using 3 x 2(2) factorial design by ionotropic gelation method...
  40. ncbi Synthesis and analgesic activity of N-Arylhydrazone derivatives of mefenamic acid
    Ali Almasirad
    Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    J Pharm Pharm Sci 8:419-25. 2005
    A series of N-Arylhydrazone derivatives of mefenamic acid (a known non-steroidal anti-inflammatory drug) were synthesized in order to obtain new compounds with potential analgesic and anti-inflammatory activity.
  41. ncbi The effects of mefenamic acid on the blood haemoglobin of the lizard, Uromastix hardwickii
    Mahmood Ahmad
    Department of Physiology, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 18:41-5. 2005
    This study deals with the effect of 7.1 mg/day, 10.5 mg/day and 14 mg/day doses of mefenamic acid administered for 12 days to three groups of Uromastix hardwickii respectively...
  42. ncbi Determinations of fluoroquinolones and nonsteroidal anti-inflammatory drugs in urine by extractive spectrophotometry and photoinduced spectrofluorimetry using multivariate calibration
    A Espinosa-Mansilla
    Department of Analytical Chemistry, University of Extremadura, Avda Elvas s n, 06071 Badajoz, Spain
    Anal Biochem 347:275-86. 2005
    ..fluoroquinolones (ciprofloxacin and ofloxacin) and two nonsteroidal anti-inflammatory drugs (diclofenac and mefenamic acid) using first- and second-order multivariate calibration methods...
  43. ncbi 'Dalmatian dog'-like skin eruption (two cases of multifocal fixed drug eruption induced by mefenamic acid)
    E Rallis
    General Military Hospital of Athens, Department of Dermatology, 138 Mesogion Ave, Athens, Greece
    J Eur Acad Dermatol Venereol 19:753-5. 2005
    b>Mefenamic acid is a common widely prescribed drug with analgesic activity. Authors report two cases of multifocal fixed drug eruption induced by mefenamic acid...
  44. ncbi Mefenamic acid shows neuroprotective effects and improves cognitive impairment in in vitro and in vivo Alzheimer's disease models
    Yuyoung Joo
    Department of Pharmacology, College of Medicine National Creative Research Initiative Center for Alzheimer s Dementia Seoul National University Seoul, 110 799, South Korea
    Mol Pharmacol 69:76-84. 2006
    ..In this study, we investigated the therapeutic potential for Alzheimer's disease of mefenamic acid, a commonly used NSAID that is a cyclooxygenase-1 and 2 inhibitor with only moderate anti-inflammatory ..
  45. ncbi Reticulated multifocal fixed drug eruption due to mefenamic acid - a new morphological pattern
    Nasser Rashid Dar
    Department of Dermatology, Combined Military Hospital, Bahawalpur Cantt, Pakistan
    J Coll Physicians Surg Pak 15:562-3. 2005
    ..We describe a new morphology of fixed drug eruption showing a reticulated pattern as a result of ingestion of mefenamic acid and discuss the possible mechanism underlying such an appearance.
  46. ncbi The effects of mefenamic acid on hematocrit of the lizard, Uromastix hardwickii
    Mahmood Ahmed
    Department of Physiology, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:48-51. 2006
    b>Mefenamic acid is an analgesic, antipyretic and anti-inflammatory agent. In addition induces several hematological disturbances...
  47. ncbi Interventions for relieving pain associated with panretinal photocoagulation: a prospective randomized trial
    W C Wu
    Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Eye (Lond) 20:712-9. 2006
    To evaluate the efficacy of pain relief by oral diazepam, acetaminophen, mefenamic acid, intramuscular ketorolac tromethamine, and peribulbar anaesthesia in panretinal photocoagulation (PRP).
  48. ncbi Inhibitory potential of nonsteroidal anti-inflammatory drugs on UDP-glucuronosyltransferase 2B7 in human liver microsomes
    Yuji Mano
    Drug Metabolism Research Laboratories, Astellas Pharma Inc, 1 8, Azusawa 1 chome, Itabashi ku, Tokyo 174 8511, Japan
    Eur J Clin Pharmacol 63:211-6. 2007
    ..The objective of this study was to identify a NSAID with potent inhibitory potential against UGT2B7 using liquid chromatography with tandem mass spectrometry (LC-MS/MS)...
  49. ncbi The effects of mefenamic acid on the osmotic fragility of lacertilian erythrocytes
    Mahmood Ahmad
    Department of Physiology, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 18:14-8. 2005
    Osmotic fragility of red cells is increased by the use of mefenamic acid. The use of this analgesic induces hemolytic anemia. Study of osmotic fragility of RBCs of control and test was observed following administration of 7.1 mg, 10...
  50. ncbi Evaluation of the bioactivity of triterpene mixture isolated from Carmona retusa (Vahl.) Masam leaves
    Irene M Villaseñor
    Institute of Chemistry, University of the Philippines, Diliman, 1101 Quezon City, Philippines
    J Ethnopharmacol 92:53-6. 2004
    ..Kruskal-Wallis one-way analysis of variance by ranks showed that the triterpene mixture is as active as mefenamic acid, a commercially available analgesic, at alpha = 0.01...
  51. ncbi Determination of degradation pathways and kinetics of acyl glucuronides by NMR spectroscopy
    Gregory S Walker
    Pfizer, Pharmacokinetics, Dynamics and Metabolism, Ann Arbor, Michigan 48015, USA
    Chem Res Toxicol 20:876-86. 2007
    ..This is particularly important, as we often have limited supply of early discovery compounds to conduct in vivo studies to generate sufficient quantities of acyl glucuronides for further characterization...
  52. ncbi Inhibition of store-operated calcium entry contributes to the anti-proliferative effect of non-steroidal anti-inflammatory drugs in human colon cancer cells
    H Weiss
    Department of General Surgery, University Hospital Innsbruck and The Tyrolean Cancer Research Institute, Innsbruck, Austria
    Int J Cancer 92:877-82. 2001
    ..Acetyl-salicylic-acid (ASA), mefenamic acid (MEF) and sulindac sulfide (SUS) inhibited cell proliferation with the following order of potency: SUS > MEF >>..
  53. ncbi Determination of non-steroidal anti-inflammatory drugs in pharmaceuticals and human serum by dual-mode gradient HPLC and fluorescence detection
    Hany Ibrahim
    Université de Toulouse Université Paul Sabatier, UMR 152, IRD, Toulouse 3, 31062, Toulouse Cedex 9, France
    J Chromatogr B Analyt Technol Biomed Life Sci 857:59-66. 2007
    Non-steroidal anti-inflammatory drugs (NSAIDs) such as piroxicam and mefenamic acid are commonly prescribed to treat inflammation, pain and fever. Similarly acetylsalicylic acid is used to prevent strokes and heart attacks...
  54. ncbi Alleviation of wound pain after surgeries for obstructive sleep apnea
    Li Ang Lee
    Department of Otolaryngology, Sleep Center, Chang Gung Memorial Hospital, and School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
    Laryngoscope 117:1689-94. 2007
    ..We performed a hospital-based study to compare the effectiveness and safety of two different regimens in the treatment of postoperative pain...
  55. ncbi The trouble with teething--misdiagnosis and misuse of a topical medicament
    P H R Wilson
    Guy s and St Thomas Hospital Trust, Great Ormond Street Hospital for Children NHS Trust, Floor 26, Guy s Tower, London SE1 9RT, UK
    Int J Paediatr Dent 12:215-8. 2002
    ..The same patient then suffered from topical analgesic misuse during the recovery period...
  56. ncbi [Fever, pneumonia and eosinophilia]
    D Berger
    Medizinische Klinik, Bürgerspital Solothurn
    Praxis (Bern 1994) 96:1543-7. 2007
    ..common etiologies and by a positive lymphocyte transformation test the non-steroidal anti-inflammatory drug mefenamic acid was identified as the possible causative agent or this potentially life threatening lung disease...
  57. ncbi Sulfation of R(-)-apomorphine in the human liver and duodenum, and its inhibition by mefenamic acid, salicylic acid and quercetin
    M Vietri
    Department of Neurosciences, Section of Pharmacology, Via Roma 55, I 56126 Pisa, Italy
    Xenobiotica 32:587-94. 2002
    ..apomorphine) in the human liver and duodenum, and to study the rate of inhibition of apomorphine sulphation by mefenamic acid, salicylic acid and quercetin also in the human liver and duodenum. 2...
  58. ncbi Influence of loading volume of mefenamic acid on granules and tablet characteristics using a compaction simulator
    Go Kimura
    Institute of Pharmaceutical Technology, Pharmacenter, University of Basel, Basel, Switzerland
    Pharm Dev Technol 12:627-35. 2007
    b>Mefenamic acid (MA), a poorly water-soluble drug, was used as a model substance to investigate granules and tablet characteristics to be optimized for the loading volume of MA (0-74...
  59. ncbi The use of complexation with alkanolamines to facilitate skin permeation of mefenamic acid
    Liang Fang
    Faculty of Pharmaceutial Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    Int J Pharm 262:13-22. 2003
    The preparation of mefenamic acid (MH)-alkanolamine [monoethanolamine, diethanolamine, triethanolamine and propanolamine] complexes was attempted to increase the transdermal flux of MH...
  60. ncbi Acute renal failure from hemoglobinuric and interstitial nephritis secondary to iodine and mefenamic acid
    R Sinniah
    Department of Pathology, National University of Singapore, Singapore
    Clin Nephrol 55:254-8. 2001
    b>Mefenamic acid ingestion, usually in excess and over prolonged period is known to produce interstitial nephritis, or less commonly papillary necrosis, with acute renal failure...
  61. ncbi [Pain management after third molar extraction. Observations of the use of mefenamic acid and rofecoxib in the treatment of postoperative pain in the dental office]
    Gion Pajarola
    Klinik für Zahn, Mund und Kieferkrankheiten und Kieferchirurgie, Poliklinik für Orale Chirurgie, Zentrum Zahnmedizin Universität Zürich, Plattenstrasse 11 CH 8028 Zürich
    Schweiz Monatsschr Zahnmed 113:887-96. 2003
    ..Additionally rofecoxib as a COX-2 selective inhibitor doesn't bear the risk for severe non-anticipatable gastrointestinal side effects or prolonged bleeding after surgical intervention...
  62. ncbi A comparative histological study of alginate beads as a promising controlled release delivery for mefenamic acid
    Ferhan Sevgi
    Department of Pharmaceutical Technology, Faculty of Pharmacy, Ege University, Izmir, Turkey
    Pharm Dev Technol 13:387-92. 2008
    The new mefenamic acid-alginate bead formulation prepared by ionotropic gelation method using 3 x 2(2) factorial design has shown adequate controlled release properties in vitro...
  63. ncbi Acute treatment and prevention of menstrually related migraine headache: evidence-based review
    Tamara Pringsheim
    Division of Neurology, University of Toronto, Toronto, Canada
    Neurology 70:1555-63. 2008
    ..Based on the evidence, grade B recommendations can be made for the use of sumatriptan 50 and 100 mg, mefenamic acid 500 mg, and rizatriptan 10 mg for the acute treatment of MRM...
  64. ncbi An unusual cause of colitis
    J N Panicker
    J Postgrad Med 53:145. 2007
  65. ncbi Double-blind study to evaluate efficacy and safety of meloxicam 7.5 mg and 15 mg versus mefenamic acid 1500 mg in the treatment of primary dysmenorrhea
    Nilson Roberto de Mello
    University of Sao Paulo, São Paulo City, Brazil
    Acta Obstet Gynecol Scand 83:667-73. 2004
    Assessment of efficacy and safety of meloxicam 7.5 mg and 15 mg once a day (o.a.d.) compared with mefenamic acid 500 mg three times a day (t.i.d...
  66. ncbi Influence of loading volume of mefenamic acid on granules and tablet characteristics using a compaction simulator
    Go Kimura
    Institute of Pharmaceutical Technology, Pharmacenter, University of Basel, Basel, Switzerland
    Pharm Dev Technol 13:57-64. 2008
    b>Mefenamic acid (MA), a poorly water-soluble drug, was used as a model substance to investigate granules and tablet characteristics to be optimized for the loading volume of MA (0-74...
  67. ncbi [Effect of acetylsalicylic and mefenamic acids on cytoarchitectonic of skin in rats with acute local cryogenic trauma]
    N A Nazarenko
    Department of Pharmacology, Archangelsk State Medical Academy, Troitskii pr 51, Archangelsk, 163051 Russia
    Eksp Klin Farmakol 66:45-7. 2003
    ..The effect depended on the treatment duration. The normal skin cytoarchitectonics was restored by acetylsalicylic acid in half, and by mephenamic acid, in one-third of cases (for a "combined" administration scheme)...
  68. ncbi Tranexamic acid: a review of its use in the management of menorrhagia
    Keri Wellington
    Adis International Limited, Auckland, New Zealand
    Drugs 63:1417-33. 2003
    ..g/day for 4-7 days reduced menstrual blood loss by 34-59% over 2-3 cycles, significantly more so than placebo, mefenamic acid, flurbiprofen, etamsylate and oral luteal phase norethisterone at clinically relevant dosages...
  69. ncbi Prevalence and clinical characteristics of headache in medical students in oman
    D Deleu
    Department of Clinical Pharmacology and Therapeutics, Sultan Qaboos University and the Neurology Clinic, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman
    Headache 41:798-804. 2001
    ..9% took nonprescription medication, and only 2.5% took traditional remedies. Acetaminophen (83.1%) followed by mefenamic acid (24.6%) were the most commonly used drugs...
  70. ncbi Solubility-excipient classification gradient maps
    Alex Avdeef
    pION INC, 5 Constitution Way Woburn, MA 01801, USA
    Pharm Res 24:530-45. 2007
    ..b>Mefenamic acid formed anionic dimers and trimers. Glibenclamide displayed a tendency to form monoanionic dimers...
  71. ncbi Fate and distribution of pharmaceuticals in wastewater and sewage sludge of the conventional activated sludge (CAS) and advanced membrane bioreactor (MBR) treatment
    Jelena Radjenovic
    Department of Environmental Chemistry, IDAEA CSIC, C Jordi Girona 18 26, 08034 Barcelona, Spain
    Water Res 43:831-41. 2009
    ..g., mefenamic acid, indomethacin, diclofenac, propyphenazone, pravastatin, gemfibrozil), whereas in some cases more stable ..
  72. ncbi Compounds exhibiting selective efficacy for different beta subunits of human recombinant gamma-aminobutyric acid A receptors
    Alison J Smith
    Sharp and Dohme Research Laboratories, Merck, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    J Pharmacol Exp Ther 311:601-9. 2004
    ..subunit selectivity, notably loreclezole, R(-)-etomidate, and a group of anti-inflammatory agents including mefenamic acid, flufenamic acid, meclofenamic acid, tolfenamic acid, niflumic acid, and diflunisal...
  73. ncbi Demographics, assessment and management of pain in the elderly
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Drugs Aging 20:23-57. 2003
    ..dextropropoxyphene and opioids that are both an agonist and antagonist, ketorolac, indomethacin, piroxicam, mefenamic acid, amitriptyline and doxepin...
  74. ncbi Optimized conditions for MDCK permeability and turbidimetric solubility studies using compounds representative of BCS classes I-IV
    Mitchell E Taub
    Novo Nordisk A S, Department of Drug Metabolism, Novo Nordisk Park, DK 2760 Maaloev, Denmark
    Eur J Pharm Sci 15:331-40. 2002
    ..used in conjunction with compounds demonstrating relatively low aqueous solubility (amphotericin B, danazol, mefenamic acid, and phenytoin) in order to obtain a drug concentration >50 microM in the donor compartment...
  75. ncbi The association between carbamazepine and valproate and adverse cutaneous drug reactions in patients with bipolar disorder: a nested matched case-control study
    Susan Shur Fen Gau
    Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan
    J Clin Psychopharmacol 28:509-17. 2008
    ....
  76. ncbi Investigating the environmental transport of human pharmaceuticals to streams in the United Kingdom
    D Ashton
    Environment Agency, National Centre for Ecotoxicology and Hazardous Substances, Evenlode House, Howbery Park, Wallingford, Oxon, OX10 8BD, UK
    Sci Total Environ 333:167-84. 2004
    ..100%, median = 76 ng/l), diclofenac (86%, median = 424 ng/l), ibuprofen (84%, median = 3086 ng/l), mefenamic acid (81%, median = 133 ng/l), dextropropoxyphene (74%, median = 195 ng/l), trimethoprim (65%, 70 ng/l), ..
  77. ncbi Bismuth(III) complexes derived from non-steroidal anti-inflammatory drugs and their activity against Helicobacter pylori
    Philip C Andrews
    School of Chemistry, Monash University, PO Box 23, Clayton, Melbourne, VIC 3800, Australia
    Dalton Trans 39:2861-8. 2010
    ..of BiPh(3) with the common non-steroidal anti-inflammatory drugs (NSAIDs) ketoprofen, naproxen, ibuprofen, mefenamic acid, diflunisal, 5-chlorosalicylic acid, fenbufen, sulindac, tolfenamic acid and flufenamic acid, has been ..
  78. ncbi Evaluation of pharmaceuticals and personal care products as water-soluble molecular markers of sewage
    Norihide Nakada
    Laboratory of Organic Geochemistry LOG, Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183 8509, Japan
    Environ Sci Technol 42:6347-53. 2008
    ..The PPCPs were crotamiton, ibuprofen, naproxen, ketoprofen, fenoprofen, mefenamic acid, thymol, triclosan, propyphenazone, carbamazepine, diethyltoluamide, ethenzamide, and caffeine...
  79. ncbi Influences of drugs on the oxygen uptake rate and biosorption of activated sludge
    Takeshi Kumagai
    First Department of Hygienic Chemistry, Tohoku Pharmaceutical University, Miyagi, Japan
    Biol Pharm Bull 29:183-6. 2006
    ..In the pharmaceutical chemical group (1) (diclofenac Na, ketoprofen, indomethacin, salicylic acid, mefenamic acid, phenylbutazone, chlorpromazine...
  80. ncbi Comparison of inhibition potentials of drugs against zidovudine glucuronidation in rat hepatocytes and liver microsomes
    Yuji Mano
    Drug Metabolism Research Laboratories, Astellas Pharma Inc, 1 8, Azusawa 1 chome, Itabashi ku, Tokyo, 174 8511, Japan
    Drug Metab Dispos 35:602-6. 2007
    ..The AZTG inhibition potentials of diclofenac, diflunisal, fluconazole, indomethacin, ketoprofen, mefenamic acid, naproxen, niflumic acid, and valproic acid in liver microsomes and hepatocytes were investigated using liquid ..
  81. ncbi Effects of anti-inflammatory drugs on convulsant activity of quinolones: a comparative study of drug interaction between quinolones and anti-inflammatory drugs
    Seiji Hori
    First Department of Pharmacology, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, 105 8461 Tokyo, Japan
    J Infect Chemother 9:314-20. 2003
    ..However, mefenamic acid, piroxicam, tenoxicam, meloxicam, etodolac, sulpyrine, isopropylantipyrine, and acetaminophen had no effect on ..
  82. ncbi Confirmatory identification of sixteen non-steroidal anti-inflammatory drug residues in raw milk by liquid chromatography coupled with ion trap mass spectrometry
    Pasquale Gallo
    Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2, 80055 Portici Na, Italy
    Rapid Commun Mass Spectrom 22:841-54. 2008
    ..5-hydroxyflunixin in the negative ion mode; the latter to identify ketoprofen, suxibutazone, diclofenac, mefenamic acid, tolfenamic acid, phenylbutazone and its metabolite oxyphenbutazone in the positive ion mode...
  83. ncbi Removal of selected pharmaceuticals and personal care products (PPCPs) and endocrine-disrupting chemicals (EDCs) during sand filtration and ozonation at a municipal sewage treatment plant
    Norihide Nakada
    Laboratory of Organic Geochemistry, Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183 8509, Japan
    Water Res 41:4373-82. 2007
    ..thymol, triclosan), 5 acidic analgesics or anti-inflammatories (ibuprofen, naproxen, ketoprofen, fenoprofen, mefenamic acid), 4 amide pharmaceuticals (propyphenazone, crotamiton, carbamazepine, diethyltoluamide), 7 antibiotics (..
  84. ncbi Hypersensitivity reactions to anthranilic acid derivatives
    M Fernandez-Rivas
    Allergy Department, Ramon y Cajal Hospital, Madrid, Spain
    Ann Allergy 71:515-8. 1993
    ..the reactions (eliciting doses: 50 mg and 15 mg, respectively), and the patient also reacted to 30 mg of mefenamic acid, an anthranilic acid derivative she had never previously received...
  85. ncbi Inhibition of sulfotransferases by xenobiotics
    Li Quan Wang
    Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
    Curr Drug Metab 7:83-104. 2006
    ..SULT activity may be inhibited when humans are exposed to certain xenobiotics including drugs (mefenamic acid, salicylic acid, clomiphene, danazol etc...
  86. ncbi Multi-residue determination of non-steroidal anti-inflammatory drug residues in animal serum and plasma by HPLC and photo-diode array detection
    Pasquale Gallo
    Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2 80055 Portici, NA, Italy
    J Chromatogr Sci 44:585-90. 2006
    ..and its metabolite (oxyphenbutazone), carprofen, ibuprofen, naproxen, niflumic acid, suxibutazone, diclofenac, mefenamic acid, and tolfenamic acid...
  87. ncbi Determination of drug residues in water by the combination of liquid chromatography or capillary electrophoresis with electrospray mass spectrometry
    W Ahrer
    Department of Analytical Chemistry, Johannes-Kepler-University Linz, Austria
    J Chromatogr A 910:69-78. 2001
    ..as paracetamol, clofibric acid, penicillin V, naproxen, bezafibrate, carbamazepine, diclofenac, ibuprofen and mefenamic acid. A 20 mM ammonium acetate solution, pH 5...
  88. pmc Activation of rabbit platelets by Ca2+ influx and thromboxane A2 release in an external Ca(2+)-dependent manner by zooxanthellatoxin-A, a novel polyol
    M C Rho
    Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Br J Pharmacol 115:433-40. 1995
    ..SK&F96365 (1-100 microM), a receptor operated Ca2+ channel antagonist, and mefenamic acid (0...
  89. pmc Management of menorrhagia in primary care-impact on referral and hysterectomy: data from the Somerset Morbidity Project
    C Grant
    Division of Primary Health Care, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR
    J Epidemiol Community Health 54:709-13. 2000
    ..To investigate the management of menorrhagia in primary care and its impact on referral and hysterectomy rates...
  90. ncbi Occurrence and a screening-level risk assessment of human pharmaceuticals in the Pearl River system, South China
    Jian Liang Zhao
    State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, P R China
    Environ Toxicol Chem 29:1377-84. 2010
    ..were detected in the rivers and effluents, including five NSAIDs (salicylic acid, ibuprofen, diclofenac, mefenamic acid, and naproxen), two BLRs (clofibric acid and gemfibrozil), and one AED (carbamazepine)...
  91. ncbi Development of an automated synthesis system for preparation of glucuronides using a solid-phase extraction column loaded with microsomes
    Yousuke Kashima
    Developmental Research Laboratories, Shionogi and Co, Ltd, Osaka 553 0002, Japan
    Chem Pharm Bull (Tokyo) 58:354-8. 2010
    ..exhibiting the uridine diphosphate (UDP)-glucuronosyltransferase activity catalyzed the glucuronidation of mefenamic acid and estradiol to the corresponding glucuronides in the presence of UDP-glucuronic acid, and three glucuronides ..
  92. ncbi Prolonged intrahepatic cholestasis after exposure to loxoprofen
    Takeshi Ichikawa
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Clin Ther 30:2402-6. 2008
    ..The objective of this report was to describe a case of prolonged intrahepatic cholestasis likely associated with the use of loxoprofen, a phenylpropionate NSAID...
  93. ncbi Rapid confirmatory analysis of non-steroidal anti-inflammatory drugs in bovine milk by rapid resolution liquid chromatography tandem mass spectrometry
    Geraldine Dowling
    The State Laboratory, Backweston Laboratory Complex, Young s Cross, Celbridge, Co Kildare, Ireland
    J Chromatogr A 1216:8117-31. 2009
    A rapid method has been developed to analyse carprofen (CPF), diclofenac (DCF), mefenamic acid (MFN), niflumic acid (NIFLU), naproxen (NAP), oxyphenylbutazone (OXYPHEN), phenylbutazone (PBZ) and suxibuzone (SUXI) residues in bovine milk...
  94. ncbi In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions
    Marjo J Karjalainen
    Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Basic Clin Pharmacol Toxicol 103:157-65. 2008
    ..In vitro, fluvoxamine, tolfenamic acid, mefenamic acid and rofecoxib potently inhibited CYP1A2 [the 50% inhibitory concentration (IC(50)) < 10 microM]...
  95. ncbi Absorption-excipient-pH classification gradient maps: sparingly soluble drugs and the pH partition hypothesis
    Alex Avdeef
    pION INC, 5 Constitution Way, Woburn, MA 01801 USA
    Eur J Pharm Sci 33:29-41. 2008
    ..helped by excipients were: clotrimazole>griseofulvin>progesterone>dipyridamole>glibenclamide>mefenamic acid>butacaine>astemizole...
  96. ncbi Benefits and risks of pharmacological agents used for the treatment of menorrhagia
    Samendra Nath Roy
    Department of Obstetrics and Gynaecology, Aberdeen Maternity Hospital, Aberdeen, United Kingdom
    Drug Saf 27:75-90. 2004
    ..Tranexamic acid and mefenamic acid are among the most effective first-line drugs used to treat menorrhagia...
  97. ncbi Development of a validated HPLC method for the determination of four 1,4-benzodiazepines in human biological fluids
    Victoria F Samanidou
    Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Sep Sci 30:679-87. 2007
    ..05 M CH3OH, and CH3CN (33:57:10 by volume). Quantification was performed at 240 nm with mefenamic acid (6 ng/microL) as the internal standard. DSC-18 Supelco cartridges provided high absolute recoveries (81-115%)...
  98. ncbi Species differences in inhibition potential of nonsteroidal anti-inflammatory drugs against estradiol 3beta-glucuronidation between rats, dogs, and humans
    Yuji Mano
    Drug Metabolism Research Laboratories, Astellas Pharma, Inc, Tokyo, Japan
    J Pharm Sci 97:2805-10. 2008
    ..NSAIDs investigated (diclofenac, diflunisal, fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen, mefenamic acid, niflumic acid, and sulindac), only niflumic acid and mefenamic acid inhibited E3G potently in all three ..
  99. ncbi Multi-residue determination of anti-inflammatory analgesics in sera by liquid chromatography--mass spectrometry
    Irina Rudik Miksa
    University of Pennsylvania, School of Veterinary Medicine, Department of Pathobiology, New Bolton Center, Toxicology, 382 West Street Road, Kennett Square, Pennsylvania 19348, USA
    J Anal Toxicol 29:95-104. 2005
    ..5 microg/mL for ACE (m/z 150), diclofenac (m/z 250), ketoprofen (m/z 209), and mefenamic acid (m/z 240); 1.0 microg/mL for oxyphenbutazone (m/z 323); 5...
  100. ncbi Fenamates and diltiazem modulate lipid-sensitive mechano-gated 2P domain K(+) channels
    Masayuki Takahira
    Department of Visual Neuroscience and Ophthalmology, Kanazawa University, Takara machi 13 1, Kanazawa 920 8640, Japan
    Pflugers Arch 451:474-8. 2005
    ..Flufenamic acid (FA, 100 microM), niflumic acid (NA, 100 microM), and mefenamic acid (MA, 100 microM) markedly stimulated TREK-1, TREK-2, and TRAAK...
  101. ncbi The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment
    Paul H Roberts
    The Centre for Environment, Fisheries and Aquaculture Science, CEFAS Burnham Laboratory, Remembrance Avenue, Burnham on Crouch, Essex CM0 8HA, UK
    Sci Total Environ 356:143-53. 2006
    ..clofibric acid, clotrimazole, dextropropoxyphene, diclofenac, erythromycin, ibuprofen, mefenamic acid, paracetamol, propranolol, sulfamethoxazole, tamoxifen and trimethoprim...

Research Grants5

  1. Non-sedating modulators of GABA-A receptors for anxiety
    KELVIN GEE; Fiscal Year: 2009
    ..to receptors containing ?1 subunits are known in the literature like tracazolate, loreclezole, etifoxine and mefenamic acid. Several of these compounds have gone through clinical trials and/or are clinically available...
  2. PHARMACOLOGIC ALTERATIONS OF SULFATE HOMEOSTASIS
    Marilyn Morris; Fiscal Year: 1993
    ..the effect of representatives of three different classes of nonsteroidal anti-inflammatory agents (ibuprofen, mefenamic acid, piroxicam) on sulfate transport, and 3) to determine the mechanism of the renal interaction between SA (and ..
  3. A Study of NSAIDS on Neuronal Ion Channels
    ROBERT HALLIWELL; Fiscal Year: 2006
    ..We have demonstrated that mefenamic acid modulates GABA-A receptors in the low therapeutic dose range and that such actions are highly receptor subtype ..
  4. Dual Allosteric Modulators of GABA-A and Nicotinic Receptors for Alzheimer's Dise
    KELVIN GEE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  5. Optimization of allosteric modulators of nicotinic receptors
    KELVIN GEE; Fiscal Year: 2008
    ..g., ADHD, Alzheimer's and other diseases involving cognitive deficit) that may be amenable to selective positive modulation of a7 nAChRs. [unreadable] [unreadable] [unreadable]..