meclofenamic acid

Summary

Summary: A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.

Top Publications

  1. ncbi Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning
    M B Kadiiska
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 38:711-8. 2005
  2. ncbi Meclofenamic acid blocks electrical synapses of retinal AII amacrine and on-cone bipolar cells
    Margaret Lin Veruki
    University of Bergen, Department of Biomedicine, Jonas Lies vei 91, N 5009 Bergen, Norway
    J Neurophysiol 101:2339-47. 2009
  3. ncbi Synthesis, crystal structures and spectroscopy of meclofenamic acid and its metal complexes with manganese(II), copper(II), zinc(II) and cadmium(II). Antiproliferative and superoxide dismutase activity
    Dimitra Kovala-Demertzi
    Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45100 Ioannina, Greece
    J Inorg Biochem 105:1187-95. 2011
  4. ncbi Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties
    Asher Peretz
    Department of Physiology and Pharmacology, Sackler Medical School, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Pharmacol 67:1053-66. 2005
  5. ncbi Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2)
    R Pouplana
    Departament de Fisicoquimica, Facultat de Farmacia, Universitat de Barcelona, Spain
    J Mol Graph Model 20:329-43. 2002
  6. ncbi Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors
    Amit S Kalgutkar
    A B Hancock, Jr, Memorial Laboratory for Cancer Research, Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Bioorg Med Chem Lett 12:521-4. 2002
  7. ncbi Organotin meclofenamic complexes: Synthesis, crystal structures and antiproliferative activity of the first complexes of meclofenamic acid - novel anti-tuberculosis agents
    Dimitra Kovala-Demertzi
    Department of Chemistry, University of Ioannina, Greece
    J Inorg Biochem 103:738-44. 2009
  8. ncbi Relaxation by urocortin of rat renal arteries: effects of diabetes in males and females
    Elena Sanz
    Departamento de Fisiologi a, Facultad de Medicina, Universidad Autonoma, Arzobispo Morcillo 2, 28029 Madrid, Spain
    Cardiovasc Res 58:706-11. 2003
  9. ncbi Effects of chronic PGHS-2 inhibition on PGHS-dependent vasoconstriction in the aged female rat
    Stephen J Armstrong
    Department of Ob Gyn and Physiology, 232 Heritage Medical Research Centre, Perinatal Research Centre, University of Alberta, Edmonton, AB, Canada T6G 2S2
    Cardiovasc Res 61:333-8. 2004
  10. pmc Mechanisms of the protective effects of urocortin on coronary endothelial function during ischemia-reperfusion in rat isolated hearts
    Angel Luis García-Villalón
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, Arzobispo Morcillo 2, 28029 Madrid, Spain
    Br J Pharmacol 145:490-4. 2005

Scientific Experts

Detail Information

Publications193 found, 100 shown here

  1. ncbi Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning
    M B Kadiiska
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 38:711-8. 2005
    ....
  2. ncbi Meclofenamic acid blocks electrical synapses of retinal AII amacrine and on-cone bipolar cells
    Margaret Lin Veruki
    University of Bergen, Department of Biomedicine, Jonas Lies vei 91, N 5009 Bergen, Norway
    J Neurophysiol 101:2339-47. 2009
    ..the junctional conductance (G(j)) between electrically coupled cells and to study the effect of the drug meclofenamic acid (MFA) on G(j)...
  3. ncbi Synthesis, crystal structures and spectroscopy of meclofenamic acid and its metal complexes with manganese(II), copper(II), zinc(II) and cadmium(II). Antiproliferative and superoxide dismutase activity
    Dimitra Kovala-Demertzi
    Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45100 Ioannina, Greece
    J Inorg Biochem 105:1187-95. 2011
    Some new complexes of meclofenamic acid (N-(2,6-dichloro-m-tolyl)anthranilic acid), Hmeclo (1), with potentially interesting biological activities are described...
  4. ncbi Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties
    Asher Peretz
    Department of Physiology and Pharmacology, Sackler Medical School, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Pharmacol 67:1053-66. 2005
    ..Here, we show that meclofenamic acid (meclofenamate) and diclofenac, two related molecules previously used as anti-inflammatory drugs, act as ..
  5. ncbi Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2)
    R Pouplana
    Departament de Fisicoquimica, Facultat de Farmacia, Universitat de Barcelona, Spain
    J Mol Graph Model 20:329-43. 2002
    ....
  6. ncbi Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors
    Amit S Kalgutkar
    A B Hancock, Jr, Memorial Laboratory for Cancer Research, Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Bioorg Med Chem Lett 12:521-4. 2002
    This paper describes SAR studies involved in the transformation of the NSAID meclofenamic acid into potent and selective cyclooxygenase-2 (COX-2) inhibitors via neutralization of the carboxylate moiety in this nonselective COX inhibitor.
  7. ncbi Organotin meclofenamic complexes: Synthesis, crystal structures and antiproliferative activity of the first complexes of meclofenamic acid - novel anti-tuberculosis agents
    Dimitra Kovala-Demertzi
    Department of Chemistry, University of Ioannina, Greece
    J Inorg Biochem 103:738-44. 2009
    The complexes [Me(2)(Meclo)SnOSn(Meclo)Me(2)](2) (2) and [Ph(3)Sn(Meclo)] (3) where HMeclo is meclofenamic acid, N-(2,6-dichloro-m-tolylanthranilic acid)], have been prepared and structurally characterized by means of vibrational, (1)H ..
  8. ncbi Relaxation by urocortin of rat renal arteries: effects of diabetes in males and females
    Elena Sanz
    Departamento de Fisiologi a, Facultad de Medicina, Universidad Autonoma, Arzobispo Morcillo 2, 28029 Madrid, Spain
    Cardiovasc Res 58:706-11. 2003
    ..Urocortin is a peptide structurally related to corticotropin releasing factor (CRF), and the present study was performed to examine the effects of diabetes mellitus on the relaxation by urocortin of renal arteries from males and females...
  9. ncbi Effects of chronic PGHS-2 inhibition on PGHS-dependent vasoconstriction in the aged female rat
    Stephen J Armstrong
    Department of Ob Gyn and Physiology, 232 Heritage Medical Research Centre, Perinatal Research Centre, University of Alberta, Edmonton, AB, Canada T6G 2S2
    Cardiovasc Res 61:333-8. 2004
    ..Subsequently, we found that, with aging, estrogen acts through suppression of the PGHS-2 isoform...
  10. pmc Mechanisms of the protective effects of urocortin on coronary endothelial function during ischemia-reperfusion in rat isolated hearts
    Angel Luis García-Villalón
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, Arzobispo Morcillo 2, 28029 Madrid, Spain
    Br J Pharmacol 145:490-4. 2005
    ..5 These results suggest that urocortin may protect coronary endothelial function during I-R by activation of PKC...
  11. ncbi Angiotensin-(1-7) potentiates responses to bradykinin but does not change responses to angiotensin I
    A Joel Greco
    Department of Pharmacology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Can J Physiol Pharmacol 84:1163-75. 2006
    ..These data suggest that ACE inhibitor-potentiated responses to BK are not mediated by an A-779-sensitive mechanism and are consistent with the hypothesis that enalaprilat-induced BK potentiation is due to decreased BK inactivation...
  12. ncbi Role of COX-2-derived metabolites in regulation of the renal hemodynamic response to norepinephrine
    M T Llinas
    Department of Physiology, School of Medicine, University of Murcia, 30100 Murcia, Spain
    Am J Physiol Renal Physiol 281:F975-82. 2001
    ..Our results show that COX-2 inhibition potentiates the renal hemodynamic effects of NE and propose that the PG involved in modulating them are mainly derived from COX-2 activity...
  13. ncbi Vasodilator responses to ATP and UTP are cAMP dependent in the mesenteric vascular bed of the cat
    M K Shah
    Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA, USA
    J Cardiovasc Pharmacol Ther 6:287-95. 2001
    ..In addition, these results suggest that the pressor component of the response to beta,gamma-MetATP is mediated by the activation of P2X(1) receptors...
  14. ncbi Diabetes abolishes the gender difference in vasopressin-mediated potentiation of sympathetic vasoconstriction
    E Sanz
    , Facultad de Medicina, , Arzobispo Morcillo 2, 28029 Madrid, Spain
    Eur J Pharmacol 427:243-50. 2001
    ....
  15. pmc Cerebral vasoconstriction produced by vasopressin in conscious goats: role of vasopressin V(1) and V(2) receptors and nitric oxide
    N Fernandez
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, Arzobispo Morcillo 2, 28029 Madrid, Spain
    Br J Pharmacol 132:1837-44. 2001
    ..Therefore, the vasopressin-induced cerebral vasoconstriction may be mediated by vasopressin V(1) receptors, without involvement of vasopressin V(2) receptors, and may be modulated by nitric oxide but not by prostanoids...
  16. ncbi Pregnancy enhances G protein activation and nitric oxide release from uterine arteries
    L P Thompson
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Heart Circ Physiol 280:H2069-75. 2001
    ..Thus the diverse effects of pregnancy on UA responsiveness may result from hormonal modulation of G proteins coupled to their specific receptors...
  17. ncbi Increased myogenic tone in 7-month-old adult male but not female offspring from rat dams exposed to hypoxia during pregnancy
    D G Hemmings
    Perinatal Research Centre, Department of Obstetrics and Gynecology, 220 Heritage Medical Research Centre, Univ of Alberta, Edmonton, AB, Canada T6G 2S2
    Am J Physiol Heart Circ Physiol 289:H674-82. 2005
    ..In summary, vascular responses in adult offspring from adverse intrauterine environments are impaired in a gender-specific, age-dependent, and maternal insult-dependent manner, with males more profoundly affected...
  18. ncbi Coronary effects of endothelin-1 and vasopressin during acute hypotension in anesthetized goats
    Nuria Fernandez
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo 2, 28029 Madrid, Spain
    Life Sci 77:423-34. 2005
    ..This increased response to endothelin-1 may be related to both inhibition of NO release and release of vasoconstrictor prostanoids...
  19. ncbi Relationship between the production of prostaglandins and progesterone by luteinizing human granulosa cells
    R C Fowkes
    Department of Biochemistry and Molecular Biology, Royal Free and University College Medical School (Royal Free Campus, University College London, Rowland Hill Street, London NW3 2PF, UK
    J Endocrinol 171:455-62. 2001
    ..01 to 10 microM meclofenamic acid or with 10 microM and 100 microM aminoglutethimide...
  20. ncbi Effects of verapamil on the renal actions induced by nitric oxide and prostaglandin synthesis inhibition
    M T Llinas
    Departamento de Fisiologia, Faculted de Medicina, Murcia, Spain
    Am J Hypertens 9:973-81. 1996
    ..Additionally, the administration of verapamil completely prevents the antinatriuretic, but not the vasoconstrictor, effects induced by the administration of a cyclooxygenase inhibitor when nitric oxide is slightly reduced...
  21. ncbi Role of nitric oxide and prostaglandin in the maintenance of cortical and renal medullary blood flow
    S I Gomez
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Braz J Med Biol Res 41:170-5. 2008
    ..This latter change induced by NO renders cortical and RMBF susceptible to a further decrease by PG inhibition. However, the decrease in medullary circulation produced by NO inhibition is not further enhanced by subsequent PG inhibition...
  22. ncbi Coronary reactivity to endothelin-1 during partial ischemia and reperfusion in anesthetized goats. Role of nitric oxide and prostanoids
    Nuria Fernandez
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, Arzobispo Morcillo 2, 28029 Madrid, Spain
    Eur J Pharmacol 457:161-8. 2002
    ....
  23. ncbi Reduced perivascular PO2 increases nitric oxide release from endothelial cells
    G P Nase
    Dept of Physiology and Biophysics, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Am J Physiol Heart Circ Physiol 285:H507-15. 2003
    ..These results indicated that in rat intestine, reduced oxygen availability increased both arteriolar and venular NO and that the main site of NO release under these conditions was from endothelial cells...
  24. ncbi Differential effects of losartan and candesartan on vasoconstrictor responses in the rat
    Bobby D Nossaman
    Department of Pharmacology, Tulane University Medical Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Can J Physiol Pharmacol 85:360-71. 2007
    ....
  25. ncbi Pregnancy-induced alterations of vascular function in mouse mesenteric and uterine arteries
    Christy Lynn M Cooke
    Perinatal Research Centre, Department of Obstetrics Gynecology, University of Alberta, Edmonton, Alberta, Canada T6G 252
    Biol Reprod 68:1072-7. 2003
    ..Understanding vascular adaptations to normal mouse pregnancy is crucial for interpreting changes that may occur in genetic mouse models...
  26. ncbi Coronary effects of vasopressin during partial ischemia and reperfusion in anesthetized goats. Role of nitric oxide and prostanoids
    María Angeles Martínez
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, Arzobispo Morcillo, 2, 28029 Madrid, Spain
    Eur J Pharmacol 473:55-63. 2003
    ....
  27. ncbi Intermedin/adrenomedullin-2 dilates the rat pulmonary vascular bed: dependence on CGRP receptors and nitric oxide release
    H Burak Kandilci
    Department of Pharmacology, Hacettepe University, Faculty of Pharmacy, 06100 Ankara, Turkey
    Peptides 27:1390-6. 2006
    ....
  28. pmc Non-steroidal anti-inflammatory drugs increase insulin release from beta cells by inhibiting ATP-sensitive potassium channels
    J Li
    Department of Anesthesia, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Br J Pharmacol 151:483-93. 2007
    ..This study investigated the effects of the NSAID meclofenamic acid (MFA) on the electrical excitability and the secretion of insulin from pancreatic beta cells.
  29. ncbi Effects of exogenous heme on renal function: role of heme oxygenase and cyclooxygenase
    Francisca Rodriguez
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Hypertension 42:680-4. 2003
    ....
  30. pmc Relaxation by urocortin of human saphenous veins
    Elena Sanz
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, 28029 Madrid, Spain
    Br J Pharmacol 136:90-4. 2002
    ..Therefore, urocortin may be of significance for regulation of the venous circulation in humans...
  31. ncbi Interactions between vasoconstrictors and vasodilators in regulating hemodynamics of distinct vascular beds
    Carlos Gomez-Alamillo
    Department of Physiology and Biophysics, Mayo Clinic, Rochester, Minn 55905, USA
    Hypertension 42:831-6. 2003
    ..These results suggest that regional differences in the interactions between endogenous Ang II, ET, NO, and PGs are important determinants in systemic, pulmonary, and regional hemodynamics...
  32. pmc Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity
    S Y M Yeung
    Division of Basic Medical Sciences, Ion Channels and Cell Signalling Research Centre, St George s, University of London, London, UK
    Br J Pharmacol 151:758-70. 2007
    ..This study represents a novel characterisation of KCNQ-encoded potassium channels in the vasculature using a variety of pharmacological and molecular tools to determine their role in contractility...
  33. ncbi Allosteric modulation of [3H]EBOB binding to GABAA receptors by diflunisal analogues
    Mikko Uusi-Oukari
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, Hungarian Academy of Sciences, H 1525 Budapest, POB 17, Hungary
    Neurochem Int 49:676-82. 2006
    ..The pharmacological relevance of these interactions is discussed. These data help to differentiate the structural requirements of these agents to act on GABAergic neurotransmission versus nonsteroidal anti-inflammatory effects...
  34. ncbi Starch-based microspheres produced by emulsion crosslinking with a potential media dependent responsive behavior to be used as drug delivery carriers
    Patricia B Malafaya
    3B s Research Group Biomaterials, Biodegradable and Biomimetics, Department of Polymer Engineering, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    J Mater Sci Mater Med 17:371-7. 2006
    ....
  35. ncbi Determination of phase II drug metabolites in equine urine by micellar electrokinetic capillary chromatography
    M R Taylor
    Horseracing Forensic Laboratory, Newmarket, Suffolk, UK
    J Chromatogr A 745:155-63. 1996
    ..optimised for the determination of morphine, morphine-3-glucuronide, morphine-6-glucuronide, normorphine, meclofenamic acid and its metabolites in equine urine...
  36. ncbi Compounds exhibiting selective efficacy for different beta subunits of human recombinant gamma-aminobutyric acid A receptors
    Alison J Smith
    Sharp and Dohme Research Laboratories, Merck, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    J Pharmacol Exp Ther 311:601-9. 2004
    ..R(-)-etomidate, and a group of anti-inflammatory agents including mefenamic acid, flufenamic acid, meclofenamic acid, tolfenamic acid, niflumic acid, and diflunisal...
  37. ncbi Adrenergic response of splanchnic arteries from cirrhotic patients: role of nitric oxide, prostanoids, and reactive oxygen species
    Adely Salcedo
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, Madrid, Spain
    Exp Biol Med (Maywood) 232:1360-7. 2007
    ..Products dependent on NAD(P)H oxidase might contribute to the adrenergic response in splanchnic arteries from control and cirrhotic patients...
  38. ncbi Endothelium-dependent relaxation of isolated splanchnic arteries from cirrhotic patients: Role of reactive oxygen species
    Adely Salcedo
    Department of Physiology, University Hospital Puerta de Hierro, Faculty of Medicine, Autonomous University, Madrid, Spain
    Hepatol Res 37:811-9. 2007
    ..Conclusions: Cirrhosis may decrease endothelial release and/or bioavailability of nitric oxide and prostacyclin in splanchnic arteries, which might be caused partly by increased production of reactive oxygen species...
  39. ncbi Endothelial-dependent relaxation induced by leukotrienes C4, D4, and E4 in isolated canine arteries
    R J Secrest
    Department of Pharmacology, St Louis University School of Medicine, Missouri 63104
    Circ Res 62:983-91. 1988
    ....
  40. ncbi Contractile responses of guinea pig trachea to oxybarbiturates and thiobarbiturates
    C Curry
    Department of Anesthesiology, Johns Hopkins Medical Institutions, Baltimore, Maryland
    Anesthesiology 75:679-83. 1991
    ..Pretreatment with meclofenamate (10(-6) M), UK 37,248 (5 x 10(-5) M), and OKY 046 (10(-6) M) prevented thiamylal-induced tracheal constriction.(ABSTRACT TRUNCATED AT 250 WORDS)..
  41. pmc The role of endothelial cells in the relaxations induced by 13-hydroxy- and 13-hydroperoxylinoleic acid in canine arteries
    G R De Meyer
    Division of Pharmacology, University of Antwerp UIA, Wilrijk, Belgium
    Br J Pharmacol 107:597-603. 1992
    ..An additional, unidentified intermediate, which was neither NO nor a cyclo-oxygenase product nor superoxide anion, contributed to the relaxations to 13-HPODE in arteries with endothelium...
  42. ncbi Response to endothelin-1 in arteries from human colorectal tumours: role of endothelin receptors
    Eduardo Ferrero
    Departamento de Cirugía General y Digestiva Section B, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain
    Exp Biol Med (Maywood) 233:1602-7. 2008
    ....
  43. ncbi Estrogen replacement suppresses a prostaglandin H synthase-dependent vasoconstrictor in rat mesenteric arteries
    S T Davidge
    Perinatal Research Centre, Department of Ob Gyn, University of Alberta, Edmonton, Canada
    Circ Res 83:388-95. 1998
    ..Chronic estrogen replacement in the ovariectomized rat suppressed this PGHS-dependent vasoconstrictor response...
  44. ncbi Confirmatory identification of sixteen non-steroidal anti-inflammatory drug residues in raw milk by liquid chromatography coupled with ion trap mass spectrometry
    Pasquale Gallo
    Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2, 80055 Portici Na, Italy
    Rapid Commun Mass Spectrom 22:841-54. 2008
    ..methods were developed: the former to identify salicylic acid, naproxen, carprofen, flurbiprofen, ibuprofen, meclofenamic acid, niflumic acid, flunixin and its metabolite 5-hydroxyflunixin in the negative ion mode; the latter to ..
  45. ncbi The effects of propofol on vascular function in mesenteric arteries of the aging rat
    Ferrante S Gragasin
    Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Canada
    Am J Physiol Heart Circ Physiol 297:H466-74. 2009
    ..Interestingly, propofol inhibits EDHF-mediated relaxation but increases availability of NO, which leads to overall vascular relaxation...
  46. ncbi Mechanism of cyclosporine A-induced renal vasoconstriction in the rat
    N F Rossi
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan
    J Pharmacol Exp Ther 250:896-901. 1989
    ..In conclusion, CSA-induced increases in renovascular resistance are complex and appear to be produced not only by actions on vascular smooth muscle cells per se but also by actions on nerve terminals...
  47. ncbi Intermedin/adrenomedullin-2 (IMD/AM2) relaxes rat main pulmonary arterial rings via cGMP-dependent pathway: role of nitric oxide and large conductance calcium-activated potassium channels (BK(Ca))
    Hilmi Burak Kandilci
    Department of Pharmacology, Hacettepe University, Faculty of Pharmacy, 06100 Ankara, Turkey
    Peptides 29:1321-8. 2008
    ..In conclusion, rIMD stimulates endothelial CRLR are coupled to release of nitric oxide, activation of guanylate cyclases, and promotion of hyperpolarization through large conductance calcium-activated K(+) channels in rat main PA...
  48. ncbi Possible roles of prostaglandins in the anteroventral third ventricular region in the hyperosmolality-evoked vasopressin secretion of conscious rats
    K Yamaguchi
    Department of Physiology, Niigata University School of Medicine, Japan
    Exp Brain Res 113:265-72. 1997
    ..On the basis of these results, we concluded that prostaglandins synthesized in and/or near the anteroventral third ventricular region might contribute to the facilitation of vasopressin release in the hyperosmotic state...
  49. ncbi Adenosine A1-receptor coupling to phosphoinositide metabolism in pregnant guinea pig myometrium
    W P Schiemann
    Department of Pharmacology, University of Nevada School of Medicine, Reno 89557
    Am J Physiol 261:E665-72. 1991
    ..Furthermore, assay of inositol phosphomonoesterase (InsPase) activity in the presence or absence of Li+ confirmed the existence of an MSM Li(+)-insensitive InsPase enzyme.(ABSTRACT TRUNCATED AT 250 WORDS)..
  50. ncbi Endothelium-dependent, vasopressin-induced contractions in rabbit renal arteries
    Jörn O Streefkerk
    Department of Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Cardiovasc Pharmacol 42:703-9. 2003
    ..To identify and quantify the stimulatory and inhibitory activity of endothelial factors on Arginine vasopressin (AVP)-induced contractions...
  51. ncbi Vasopressin effects on the coronary circulation after a short ischemia in anesthetized goats: role of nitric oxide and prostanoids
    Godofredo Dieguez
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, Arzobispo Morcillo 2, 28029 Madrid, Spain
    Eur J Pharmacol 495:171-7. 2004
    ....
  52. ncbi Vascular reactivity to vasopressin during diabetes: gender and regional differences
    Angel Luis García-Villalón
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, Arzobispo Morcillo 2, 28029, Madrid, Spain
    Eur J Pharmacol 459:247-54. 2003
    ..Therefore, the effects of diabetes on vascular reactivity to vasopressin may differ between vascular beds, and the mechanisms underlay these effects may be distinct between genders...
  53. pmc Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents
    Roberta S King
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA
    Curr Drug Metab 7:745-53. 2006
    ..The inhibition of SULT1A1 by meclofenamate, nimesulide, salicylate and aspirin may be clinically relevant based on ratio of inhibition constant to predicted in vivo inhibitor concentration ([I]/IC(50) > 1)...
  54. ncbi Elevation of intraluminal pressure and cyclooxygenase inhibitors increases duodenal alkaline secretion
    M Sababi
    Department of Physiology and Medical Biophysics, Uppsala University, Sweden
    Am J Physiol 266:G22-30. 1994
    ..It is speculated that the indomethacin-induced rise in DMAS is mediated via induction of duodenal motility...
  55. ncbi Use of accelerating solvent extraction for detecting non-steroidal anti-inflammatory drugs in horse feces
    M A Popot
    LCH, 15 rue de Paradis, 91370 Verrieres le Buisson, France
    J Anal Toxicol 30:323-30. 2006
    ..Extraction recovery and limit of detection have been determined for several NSAIDs, such as meclofenamic acid, flunixin, vedaprofen, celecoxib, carprofen, diclofenac, and ketoprofen...
  56. ncbi Meta-analysis of dyspepsia and nonsteroidal antiinflammatory drugs
    Joshua J Ofman
    Cedars Sinai Health System and Zynx Health Inc, Los Angeles, California 90212, USA
    Arthritis Rheum 49:508-18. 2003
    ..Using published and unpublished data sources, we sought to determine estimates of the risks of dyspepsia associated with NSAIDs...
  57. ncbi Hyperoxia and alkalosis produce pulmonary vasodilation independent of endothelium-derived nitric oxide in newborn lambs
    J R Fineman
    Department of Pediatrics, University of California San Francisco 94143
    Pediatr Res 33:341-6. 1993
    ..The lambs were sedated, paralyzed, and mechanically ventilated. Meclofenamic acid was infused to inhibit prostaglandin synthesis...
  58. ncbi Selective tumor blood-brain barrier opening with the kinin B2 receptor agonist [Phe(8)psi(CH(2)NH)Arg(9)]-BK in a F98 glioma rat model: an MRI study
    Jérôme Côté
    Department of Nuclear Medicine and Radiobiology, Universite de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4
    Neuropeptides 44:177-85. 2010
    ..We concluded that R523 allows the extravasation of hydrophilic macromolecular agents (17kDa) into tumor tissues by inducing selective tumor BBB permeability via B2R- and NO-dependent mechanisms...
  59. ncbi Mechanisms of endothelium-dependent vasodilation in male and female, young and aged offspring born growth restricted
    J S Morton
    Department of Obstetrics, 232 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, T6G 2S2, Canada
    Am J Physiol Regul Integr Comp Physiol 298:R930-8. 2010
    ..A change in the mechanisms of vasodilation occurring at an earlier age in IUGR offspring may predispose them to adult cardiovascular diseases...
  60. ncbi Pulmonary vascular reactivity to endothelin-1 in normal and chronically pulmonary hypertensive rats
    S Eddahibi
    , , , France
    J Cardiovasc Pharmacol 17:S358-61. 1991
    ..During chronic hypoxic pulmonary hypertension, ET-1 behaves only as a pulmonary vasoconstrictor...
  61. ncbi Analysis of emerging contaminants in sewage effluent and river water: comparison between spot and passive sampling
    Zulin Zhang
    Department of Biology and Environmental Science, School of Life Sciences, University of Sussex, Falmer, East Sussex, Brighton BN1 9QG, UK
    Anal Chim Acta 607:37-44. 2008
    ..sulfamethoxazole, meberverine, thioridazine, carbamazepine, tamoxifen, indomethacine, diclofenac and meclofenamic acid in sewage effluent and river water...
  62. ncbi Variable effects of nonsteroidal antiinflammatory agents on thyroid test results
    M H Samuels
    Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Clin Endocrinol Metab 88:5710-6. 2003
    ..TSH remained within the normal range during acute or 1-wk administration of all of the NSAIDs...
  63. ncbi Endothelium-derived contracting factor released by serotonin in the aorta of the spontaneously hypertensive rat
    W Auch-Schwelk
    Mayo Clinic, Department of Physiology and Biophysics, Rochester, Minnesota
    Am J Hypertens 4:769-72. 1991
    ..Norepinephrine may release endothelium-derived contracting factor(s) in both strains...
  64. ncbi Simultaneous determination of various pharmaceutical compounds in water by solid-phase extraction-liquid chromatography-tandem mass spectrometry
    Z L Zhang
    Department of Biology and Environmental Science, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Chromatogr A 1154:205-13. 2007
    ..sulfamethoxazole, meberverine, thioridazine, carbamazepine, tamoxifen, mecoprop, indomethacine, diclofenac, meclofenamic acid and monensin) in environmental water samples...
  65. ncbi Benidipine improves endothelial function in renal resistance arteries of hypertensive rats
    Y Dohi
    Second Department of Internal Medicine, Nagoya City University Hospital, Japan
    Hypertension 28:58-63. 1996
    ..In vitro treatment with meclofenamic acid, a cyclooxygenase inhibitor, did not alter the differences in the relaxations...
  66. ncbi Role of alpha-adrenoceptors and prostacyclin in the enhanced adrenergic reactivity of goat cerebral arteries after ischemia-reperfusion
    Luis Monge
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, 28029 Madrid, Spain
    Brain Res 1346:121-31. 2010
    ..After ischemia-reperfusion, noradrenaline might increase PGI(2) production thus contributing to adrenergic vasoconstriction and/or PGI(2) would potentiate the noradrenaline effects...
  67. ncbi Suppression of proteoglycan synthesis in chondrocyte cultures derived from canine intervertebral disc
    J U Yoo
    Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio
    Spine (Phila Pa 1976) 17:221-4. 1992
    ....
  68. ncbi Altered sensitivity of aspirin-acetylated prostaglandin G/H synthase-2 to inhibition by nonsteroidal anti-inflammatory drugs
    J A Mancini
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
    Mol Pharmacol 51:52-60. 1997
    ..However, two potent, structurally related NSAIDs, diclofenac and meclofenamic acid, do not inhibit either ASA-PGHS-2 or the PGHS-2(S516M) mutant...
  69. ncbi Effect of sulfidopeptide leukotrienes D4 and E4 on ileal ion transport in vitro in the rat and rabbit
    P L Smith
    Department of Advanced Drug Delivery, Smith Kline and French Laboratories, Philadelphia, PA 19101
    Am J Physiol 255:G175-83. 1988
    ..replacement, reduction of bathing solution [Ca2+] to 1 microM or pretreatment with 1 microM indomethacin or meclofenamic acid inhibited the LTD4- or LTE4-induced Isc changes with no effect on the decrease in Gt...
  70. ncbi Pulmonary vasodilation to adrenomedullin: a novel peptide in humans
    J Heaton
    Department of Anesthesiology, Louisiana State University Medical School, New Orleans, USA
    Am J Physiol 268:H2211-5. 1995
    ..abstract truncated at 250 words)..
  71. ncbi Modulation of vascular reactivity to serotonin in the dog lung
    W F Hofman
    Department of Physiology and Endocrinology, Medical College of Georgia, Augusta 30912
    J Appl Physiol (1985) 71:217-22. 1991
    ..Our results suggest that both PGI2 and endothelium-derived relaxing factors modulate pulmonary vascular reactivity to 5-HT.(ABSTRACT TRUNCATED AT 250 WORDS)..
  72. ncbi Quantitation of indomethacin in serum and plasma using gas chromatography-mass spectrometry (GC-MS)
    Sarah Thomas
    Department of Pathology and Laboratory Medicine, Children s Mercy Hospitals and Clinics, Kansas City, MO, USA
    Methods Mol Biol 603:297-305. 2010
    ..Quantitation of the drug in a sample is achieved by comparing responses of the unknown sample to the responses of the calibrators using selected ion monitoring. Meclofenamic acid is used as an internal standard.
  73. pmc Role of endoperoxides in arachidonic acid-induced vasoconstriction in the isolated perfused kidney of the rat
    J Quilley
    Department of Pharmacology, New York Medical College, Valhalla
    Br J Pharmacol 96:111-6. 1989
    ..5. These data suggest that the vasoconstrictor effect of arachidonic acid in the isolated kidney of the rat is mediated by its metabolites, including the prostaglandin endoperoxides...
  74. ncbi Second-order calibration of excitation-emission matrix fluorescence spectra for the determination of N-phenylanthranilic acid derivatives
    A Muñoz de la Peña
    Departamento de Quimica Analitica, Facultad de Ciencias, Universidad de Extremadura, 06071, Badajoz, Espana
    Appl Spectrosc 60:330-8. 2006
    ..Improved results over unfolded-PLS and N-PLS were found with PARAFAC, SWATLD, and BLLS, methods that exploit the second-order advantage...
  75. ncbi Analysis of vasodilator responses to peroxynitrite in the hindlimb vascular bed of the cat
    Bobby D Nossaman
    Department of Anesthesiology, Ochsner Health System, New Orleans, Louisiana, USA
    J Cardiovasc Pharmacol 50:358-66. 2007
    ..These studies suggest that under physiologic conditions, the cytotoxic effects of (ONOO-) on a short-term basis may have been overemphasized...
  76. ncbi Urotensin II-induced hypotensive responses in Wistar-Kyoto (Wky) and spontaneously hypertensive (Shr) rats
    Gabrielle Gendron
    Department of Pharmacology, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Canada J1H 5N4
    Peptides 26:1468-74. 2005
    ....
  77. ncbi Cyclooxygenase-2 inhibition normalizes arterial blood pressure in CYP1A1-REN2 transgenic rats with inducible ANG II-dependent malignant hypertension
    Allison L Opay
    Department of Physiology, Tulane University Health Sciences Center, 1430 Tulane Ave, SL39, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 291:F612-8. 2006
    ..The data also indicate that COX-2-derived vasodilatory metabolites play an important role in the maintenance of RPF and GFR following induction of malignant hypertension in Cyp1a1-Ren2 transgenic rats...
  78. ncbi Analysis of responses to kava kava in the feline pulmonary vascular bed
    Jason M Hoover
    Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Med Food 9:62-71. 2006
    ..The results of this investigation suggest that kava has potent vasodepressor activity in the feline lung bed and that this response is mediated or modulated by both a calcium channel- and GABA receptor-sensitive pathway...
  79. ncbi What regulates placental steroidogenesis in 90-day pregnant ewes?
    Yoshie S Weems
    Department of Human Nutrition, Food, and Animal Sciences, University of Hawaii, Honolulu, HI 96822, United States
    Prostaglandins Other Lipid Mediat 84:54-65. 2007
    ..05) progesterone secretion only in ewes treated with INDO or MECLO. It is concluded that FSH probably regulates day-90 ovine placental estradiol-17beta secretion, while PGE(l) or PGE(2) regulates day-90 placental progesterone secretion...
  80. ncbi Endothelin-1 potentiation of coronary artery contraction after ischemia-reperfusion
    Angel Luis García-Villalón
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, 28029 Madrid, Spain
    Vascul Pharmacol 48:109-14. 2008
    ....
  81. ncbi Role for prostaglandins in the regulation of type 1 11beta-hydroxysteroid dehydrogenase in human granulosa-lutein cells
    Kim C Jonas
    Department of Biochemistry and Molecular Biology, Royal Free and University College Medical School, University College London, UK
    Endocrinology 147:5865-72. 2006
    ..of basal PG synthesis using four different inhibitors of PG H synthase enzymes [indomethacin, niflumic acid, meclofenamic acid (MA) and N-(2-cyclohexyloxy-4-nitorophenyl) methane sulfonamide (NS-398)] each resulted in significant ..
  82. ncbi Analysis of responses to St. John's Wort in the feline pulmonary vascular bed
    Jason M Hoover
    Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX 79430, USA
    J Herb Pharmacother 4:47-62. 2004
    ..To test the hypothesis that St. John's wort induces a depressor response in the feline pulmonary vascular bed and identify the pathways involved in the mediation or modulation of these effects...
  83. ncbi Determination of fourteen non-steroidal anti-inflammatory drugs in animal serum and plasma by liquid chromatography/mass spectrometry
    Floriana Vinci
    Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2, 80055 Portici Na, Italy
    Rapid Commun Mass Spectrom 20:3412-20. 2006
    ..one for the determination of salicylic acid, naproxen, carprofen, flurbiprofen, ibuprofen, niflumic acid and meclofenamic acid in the negative ion mode, and the other for the determination of ketoprofen, suxibutazone, diclofenac, ..
  84. pmc A tale of switched functions: from cyclooxygenase inhibition to M-channel modulation in new diphenylamine derivatives
    Asher Peretz
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 2:e1332. 2007
    ..Our results reveal a new and crucial determinant of NSAID-mediated COX inhibition. They also provide a structural framework for designing novel M-channel modulators, including openers and blockers...
  85. ncbi Coronary action of endothelin-1 and vasopressin during acute hypertension in anesthetized goats. Role of nitric oxide and prostanoids
    Nuria Fernandez
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, Arzobispo Morcillo 2, 28029 Madrid, Spain
    Vascul Pharmacol 41:131-8. 2004
    ..Therefore, during acute, moderate hypertension, the coronary vasoconstriction to endothelin-1 and vasopressin is attenuated, which may be related with increased NO release but not with prostanoids...
  86. ncbi Coronary response to diadenosine pentaphosphate after ischaemia-reperfusion in the isolated rat heart
    Angel Luis García-Villalón
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo 2, 28029 Madrid, Spain
    Cardiovasc Res 81:336-43. 2009
    ..The objective of this study was to analyse their effects in such conditions...
  87. pmc Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs
    Daniel E Westholm
    Department of Pharmacy Practice and Pharmaceutical Sciences, University of Minnesota Duluth, Duluth, MN 55812, USA
    Endocrinology 150:1025-32. 2009
    ..Phenytoin (64%), indocyanine green (17%), fenamic acid (68%), diclofenac (51%), and meclofenamic acid (33%) all reduced T(4) uptake by Oatp1c1 when assayed at concentrations of 10 microM...
  88. ncbi Predicting sorption of pharmaceuticals and personal care products onto soil and digested sludge using artificial neural networks
    Leon Barron
    National Centre for Sensor Research, Dublin City University, Glasnevin, Dublin 9, Republic of Ireland
    Analyst 134:663-70. 2009
    ..To evaluate the developed model, it was used to predict K(d) for meclofenamic acid, mefenamic acid, ibuprofen and furosemide and subsequently compared to experimentally determined values in ..
  89. ncbi In vivo coronary effects of endothelin-1 after ischemia-reperfusion. Role of nitric oxide and prostanoids
    Nuria Fernandez
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, Arzobispo Morcillo 2, 28029, Madrid, Spain
    Eur J Pharmacol 481:109-17. 2003
    ....
  90. ncbi Analysis of ketamine responses in the pulmonary vascular bed of the cat
    A D Kaye
    Department of Anesthesiology, Tulane University Medical School, New Orleans, Louisiana, USA
    Crit Care Med 28:1077-82. 2000
    ....
  91. ncbi Evaluation of androgenic activity of nutraceutical-derived steroids using mammalian and yeast in vitro androgen bioassays
    Omar N Akram
    Lipid Research Group, The Heart Research Institute, Sydney, Australia
    Anal Chem 83:2065-74. 2011
    ..rank RP of these compounds was reconciled into a consistent potency ranking when the cells were treated with meclofenamic acid, a nonselective inhibitor of steroid metabolizing enzymes...
  92. ncbi Dimethylphenylpiperazinium (DMPP)-induced relaxation and elevation of cyclic GMP content in canine lower esophageal sphincter (LES)
    M Grous
    Department of Pharmacology, Smith Kline and French Laboratories, King of Prussia, PA 19406
    Biochem Pharmacol 40:1757-62. 1990
    ..The combination of phentolamine and meclofenamic acid also antagonized both the relaxation and the elevation of cyclic GMP produced by DMPP...
  93. pmc Synergy between electrical coupling and membrane properties promotes strong synchronization of neurons of the mesencephalic trigeminal nucleus
    Sebastian Curti
    Laboratorio de Neurofisiología Celular, Departamento de Fisiologia, Facultad de Medicina, Universidad de la Republica, Montevideo 11800, Uruguay
    J Neurosci 32:4341-59. 2012
    ....
  94. ncbi Methylene blue prevents hypoxic pulmonary vasoconstriction in cats
    A L Hyman
    Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana 70112
    Am J Physiol 260:H586-92. 1991
    ..The effects of methylene blue on vascular tone and responses to hypoxia and acetylcholine were reversible, and responses returned to control value after the infusion was terminated.(ABSTRACT TRUNCATED AT 250 WORDS)..
  95. ncbi The role of arachidonic acid metabolism in IL-3-induced proliferation
    B E Barton
    Department of Biochemistry, Allergan Inc, Irvine, CA 92715
    Immunopharmacol Immunotoxicol 10:35-52. 1988
    ..neither prostaglandins nor leukotrienes were involved in signal transduction, since aspirin, indomethacin, meclofenamic acid, and nordihydroguaiaretic acid (NDGA) failed to inhibit the proliferation response of DA-1 cells to IL-3...
  96. pmc Intrinsic oscillatory activity arising within the electrically coupled AII amacrine-ON cone bipolar cell network is driven by voltage-gated Na+ channels
    Stuart Trenholm
    Department of Anatomy, Dalhousie University, Halifax, NS, Canada B3H 1X5
    J Physiol 590:2501-17. 2012
    ..Pharmacologically uncoupling the network (200 μm meclofenamic acid (MFA)) blocked oscillations in all cells indicating that Na(+) channels exert their influence over multiple ..
  97. ncbi Idiosyncratic NSAID drug induced oxidative stress
    Giuseppe Galati
    Department of Pharmacology, University of Toronto, Toronto, Ont, Canada M5S 2S2
    Chem Biol Interact 142:25-41. 2002
    ..effectiveness of fenamate and arylacetic acid NSAIDs was mefenamic acid>tolfenamic acid>flufenamic acid, meclofenamic acid or diclofenac...
  98. pmc Group B Streptococcus and E. coli LPS-induced NO-dependent hyporesponsiveness to noradrenaline in isolated intrapulmonary arteries of neonatal piglets
    E Villamor
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 115:261-6. 1995
    ..Thus, induction of NOS seems to be responsible for the delayed pulmonary vascular hyporesponsiveness induced by GBS (a Gram-positive) and E. coli (a Gram-negative), the most common causal agents of neonatal sepsis...
  99. ncbi Developmental effects of endothelin-1 on the pulmonary circulation in sheep
    J Wong
    Department of Pediatrics, University of California, San Francisco 94143
    Pediatr Res 36:394-401. 1994
    ..In juvenile sheep, the increase in resting pulmonary arterial pressure produced by ET-1 was inhibited by meclofenamic acid, an inhibitor of prostaglandin synthesis (40.3 +/- 9.9% versus 2.3 +/- 4.7%, p < 0...
  100. ncbi Resveratrol protects human retinal pigment epithelial cells from acrolein-induced damage
    Shwu Jiuan Sheu
    Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan
    J Ocul Pharmacol Ther 26:231-6. 2010
    ..The purpose of this study was to examine the potential protective effects of lutein, zeaxanthin, meclofenamic acid, and resveratrol on the acrolein-induced oxidative stress in human RPE cells.
  101. ncbi NO and prostaglandin interactions during hemodynamic stress in the fetal ovine pulmonary circulation
    J P Zenge
    Section of Neonatology, Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1157-63. 2001
    ..001). We conclude that NO has a greater role than PGs in fetal pulmonary vasoregulation during acute hemodynamic stress and that PGI(2)-induced pulmonary vasodilation is largely mediated by NO release in the fetal lung...

Research Grants7

  1. Interleukin and the Magnocellular Neuroendocrine System
    Joan Summy Long; Fiscal Year: 2005
    ..abstract_text> ..
  2. COMPLEMENT-DEPENDENT PROSTAGLANDIN SYNTHESIS IN SEPSIS
    Mitchell Fink; Fiscal Year: 1991
    ..These studies should provide important new insights into the mechanisms underlying the derangements in vasomotor tone in sepsis and possibly lead to improved therapeutic strategies...
  3. SEROTONIN AND EICOSANOID INTERACTION IN LUNG VASOMOTION
    WENDELL HOFMAN; Fiscal Year: 1992
    ..The proposed investigations will provide new insights into the mechanism and physiological significance of interactions between serotonin and metabolites of AA in the regulation of pulmonary vasoreactivity...
  4. INHIBITION OF 3A HSD BY ANTI-INFLAMMATORY DRUGS
    TREVOR PENNING; Fiscal Year: 1991
    ..These studies may provide information for a rational approach to the design of superior antiinflammatory drugs...
  5. RENAL INPUT TO SPINORETICULAR AND SPINOTHALAMIC NEURONS
    W Ammons; Fiscal Year: 1991
    ..Such information will provide new insights into the mechanisms of renal pain and renal reflexes and perhaps begin to explain the variability of renal pain...
  6. Neurocognitive effects of subclinical thyroid disease
    Mary Samuels; Fiscal Year: 2004
    ..Based on these pilot studies, it is the long-term goal of the investigator to investigate specific cognitive effects of altered thyroid status in the adult human. ..
  7. Pulmonary Arterial Hypertension: Avian Model of Complex Vascular Lesion Developme
    ROBERT WIDEMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..