benzocaine

Summary

Summary: A surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.

Top Publications

  1. ncbi Reducing children's injection pain: lidocaine patches versus topical benzocaine gel
    K A Kreider
    University of Texas-Houston Health Science Center, Houston, TX, USA
    Pediatr Dent 23:19-23. 2001
  2. ncbi Severe methemoglobinemia on reexposure to benzocaine
    C Udeh
    Duke University Medical Center, Durham, NC 27710, USA
    J Clin Anesth 13:128-30. 2001
  3. ncbi Methemoglobinemia caused by topical teething preparation: a case report
    Ran D Balicer
    Department of Family Medicine, Sackler School of Medicine, Tel Aviv University, Sheba Medical Center, Building 130, IL 52621 Tel Hashomer, Israel
    ScientificWorldJournal 4:517-20. 2004
  4. ncbi Severe methemoglobinemia complicating topical benzocaine use during endoscopy in a toddler: a case report and review of the literature
    Ahmed Dahshan
    Division of Pediatric Gastroenterology, Department of Pediatrics, University of Oklahoma College of Medicine, Tulsa, OK 74135, USA
    Pediatrics 117:e806-9. 2006
  5. ncbi Development, characterization and in vivo evaluation of benzocaine-loaded liposomes
    Paola Mura
    Department of Pharmaceutical Sciences, University of Florence, Italy
    Eur J Pharm Biopharm 67:86-95. 2007
  6. ncbi The effect of clove and benzocaine versus placebo as topical anesthetics
    Athbi Alqareer
    Faculty of Dentistry, Kuwait University, Kuwait
    J Dent 34:747-50. 2006
  7. ncbi Topical anesthesia for rubber dam clamp placement in sealant placement: comparison of lidocaine/prilocaine gel and benzocaine
    Richard K Yoon
    Division of Pediatric Dentistry, Columbia University College of Dental Medicine, New York City, NY, USA
    Pediatr Dent 31:377-81. 2009
  8. ncbi Evaluation of topical pharyngeal anaesthesia by benzocaine lozenge for upper endoscopy
    R Shaoul
    Department of Pediatrics, Bnai Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel
    Aliment Pharmacol Ther 24:687-94. 2006
  9. ncbi Interaction of local anesthetics with a peptide encompassing the IV/S4-S5 linker of the Na+ channel
    Leonardo F Fraceto
    Center of Molecular and Structural Biology, LNLS, Campinas, Brazil Department of Biochemistry, Institute of Biology, State University of Campinas, Campinas, Brazil
    Biophys Chem 123:29-39. 2006
  10. ncbi The different use dependences of tocainide and benzocaine are correlated with different effects on sodium channel inactivation
    A Deluca
    Abteilung für Allgemeine Physiologie, Universitat Ulm, Federal Republic of Germany
    Naunyn Schmiedebergs Arch Pharmacol 344:596-601. 1991

Detail Information

Publications178 found, 100 shown here

  1. ncbi Reducing children's injection pain: lidocaine patches versus topical benzocaine gel
    K A Kreider
    University of Texas-Houston Health Science Center, Houston, TX, USA
    Pediatr Dent 23:19-23. 2001
    ..minute application of DentiPatch (20% lidocaine) or a 1 minute application of topical anesthetic gel (Topex, 20% benzocaine)...
  2. ncbi Severe methemoglobinemia on reexposure to benzocaine
    C Udeh
    Duke University Medical Center, Durham, NC 27710, USA
    J Clin Anesth 13:128-30. 2001
    We report a 65-year-old male who developed severe methemoglobinemia only on reexposure to benzocaine. The patient needed two awake fiberoptic intubations for emergency surgeries...
  3. ncbi Methemoglobinemia caused by topical teething preparation: a case report
    Ran D Balicer
    Department of Family Medicine, Sackler School of Medicine, Tel Aviv University, Sheba Medical Center, Building 130, IL 52621 Tel Hashomer, Israel
    ScientificWorldJournal 4:517-20. 2004
    Methemoglobinemia (MetHb) remains an uncommon, but potentially fatal disorder. Benzocaine (ethyl aminobenzoate), a topical anesthetic, has been reported to cause acquired MetHb when used during endoscopic or other ambulatory procedures...
  4. ncbi Severe methemoglobinemia complicating topical benzocaine use during endoscopy in a toddler: a case report and review of the literature
    Ahmed Dahshan
    Division of Pediatric Gastroenterology, Department of Pediatrics, University of Oklahoma College of Medicine, Tulsa, OK 74135, USA
    Pediatrics 117:e806-9. 2006
    Severe methemoglobinemia resulting from the use of topical benzocaine has been reported in adults as a rare complication...
  5. ncbi Development, characterization and in vivo evaluation of benzocaine-loaded liposomes
    Paola Mura
    Department of Pharmaceutical Sciences, University of Florence, Italy
    Eur J Pharm Biopharm 67:86-95. 2007
    This study reports the development and in vivo evaluation of a liposomal formulation of the local anaesthetic benzocaine. Multi-lamellar (MLV) and small uni-lamellar (SUV) vesicles entrapping benzocaine were prepared using 50:50 w/w ..
  6. ncbi The effect of clove and benzocaine versus placebo as topical anesthetics
    Athbi Alqareer
    Faculty of Dentistry, Kuwait University, Kuwait
    J Dent 34:747-50. 2006
    The purpose of this study was to examine whether the natural herb clove can replace benzocaine as a topical anesthetic.
  7. ncbi Topical anesthesia for rubber dam clamp placement in sealant placement: comparison of lidocaine/prilocaine gel and benzocaine
    Richard K Yoon
    Division of Pediatric Dentistry, Columbia University College of Dental Medicine, New York City, NY, USA
    Pediatr Dent 31:377-81. 2009
    The purpose of this prospective study was to compare the efficacy of Oraqix to benzocaine while placing a rubber dam clamp during sealant placement on children.
  8. ncbi Evaluation of topical pharyngeal anaesthesia by benzocaine lozenge for upper endoscopy
    R Shaoul
    Department of Pediatrics, Bnai Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel
    Aliment Pharmacol Ther 24:687-94. 2006
    ..We hypothesized that delivering the local anaesthetic as a sucking lozenge would benefit the patients in terms of decreasing anxiety and will improve procedure performance and patient tolerance...
  9. ncbi Interaction of local anesthetics with a peptide encompassing the IV/S4-S5 linker of the Na+ channel
    Leonardo F Fraceto
    Center of Molecular and Structural Biology, LNLS, Campinas, Brazil Department of Biochemistry, Institute of Biology, State University of Campinas, Campinas, Brazil
    Biophys Chem 123:29-39. 2006
    ..The interaction of two local anesthetics (LA), lidocaine and benzocaine, with pIV/S4-S5 has been studied by DOSY, heteronuclear NMR 1H-15N-HSQC spectroscopy and computational methods...
  10. ncbi The different use dependences of tocainide and benzocaine are correlated with different effects on sodium channel inactivation
    A Deluca
    Abteilung für Allgemeine Physiologie, Universitat Ulm, Federal Republic of Germany
    Naunyn Schmiedebergs Arch Pharmacol 344:596-601. 1991
    ..For comparison, the experiments were also conducted with 1 mM benzocaine, a drug with almost no use dependence...
  11. doi Bioadhesive films containing benzocaine: correlation between in vitro permeation and in vivo local anesthetic effect
    Daniele Ribeiro de Araujo
    Human and Natural Sciences Center, Federal University of ABC UFABC, Santo Andre, SP, Brazil
    Pharm Res 27:1677-86. 2010
    The aim of this work was to develop anesthetic bioadhesive films containing benzocaine and study their in vitro skin permeation and in vivo performance, in comparison with commercial formulations.
  12. pmc Benzocaine-induced methemoglobinemia: a potentially fatal complication of transesophageal echocardiography
    Rajesh Sachdeva
    Division of Cardiology, Department of Medicine, Bridgeport Hospital, Yale School of Medicine, Bridgeport, Connecticut 06610, USA
    Tex Heart Inst J 30:308-10. 2003
    We describe the cases of 2 patients who developed benzocaine-induced methemoglobinemia after the administration of benzocaine as premedication for transesophageal echocardiography...
  13. ncbi Methemoglobinemia and benzocaine
    Daniel D Moos
    Kearney Anesthesia Associates P C, Bryan LGH College of Health Sciences, Nurse Anesthesia Program, Kearney, Nebraska 68847, USA
    Gastroenterol Nurs 30:342-5; quiz 346-7. 2007
    b>Benzocaine administration to facilitate upper endoscopic procedures can result in the relatively uncommon but potentially fatal complication known as methemoglobinemia...
  14. ncbi Canister tip orientation and residual volume have significant impact on the dose of benzocaine delivered by Hurricaine spray
    A Khorasani
    Division of Critical Care Anesthesiology and Department of Anesthesiology and Pain Management, Cook County Hospital, Chicago, IL 60612, USA
    Anesth Analg 92:379-83. 2001
    Delivered quantities of 20% benzocaine spray (Hurricaine; Beutlich L.P. Pharmaceuticals, Waukegan, IL) are estimated by counting the number of sprays or the spraying time...
  15. ncbi Benzocaine-induced methemoglobinemia: experience from a high-volume transesophageal echocardiography laboratory
    Gian M Novaro
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, OH 44195, USA
    J Am Soc Echocardiogr 16:170-5. 2003
    b>Benzocaine (ethyl aminobenzoate), a topical anesthetic widely used before transesophageal echocardiography, has been reported to cause acquired methemoglobinemia...
  16. ncbi Efficacy and tolerability of an intraoral benzocaine patch in the relief of spontaneous toothache pain
    Elliot V Hersh
    University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA
    J Clin Dent 14:1-6. 2003
    ..double-blind, placebo-controlled clinical trial, the effectiveness and tolerability of a novel intraoral benzocaine patch was evaluated in 60 patients who presented to the Dental School's emergency clinic with spontaneous ..
  17. ncbi Reported adverse event cases of methemoglobinemia associated with benzocaine products
    Thomas J Moore
    Institute for Safe Medication Practices, Huntingdon Valley, PA, USA
    Arch Intern Med 164:1192-6. 2004
    ..When induced by benzocaine anesthetic spray and other chemicals, it can result in cyanosis and life-threatening complications.
  18. ncbi Optimization of formulation variables of benzocaine liposomes using experimental design
    Paola Mura
    Department of Pharmaceutical Sciences, University of Florence, Florence, Italy
    J Liposome Res 18:113-25. 2008
    ..design multivariate strategy, a liposomal formulation for topical delivery of the local anaesthetic agent benzocaine. The formulation variables for the vesicle lipid phase uses potassium glycyrrhizinate (KG) as an alternative to ..
  19. ncbi Physico-chemical characterization of benzocaine-beta-cyclodextrin inclusion complexes
    Luciana M A Pinto
    Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas, Cidade Universitaria Zeferino Vaz, S N, C P 6109, 13083 970 Campinas, SP, Brazil
    J Pharm Biomed Anal 39:956-63. 2005
    ..b>Benzocaine (BZC) is a local anesthetic whose low water-solubility limits its application to topical formulations...
  20. ncbi Atomic determinants of state-dependent block of sodium channels by charged local anesthetics and benzocaine
    Denis B Tikhonov
    Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ont, Canada L8N 3Z5
    FEBS Lett 580:6027-32. 2006
    ..LA binds in the focus of the pore-helices macrodipoles, which also stabilize a Na(+) ion chelated by two benzocaine molecules...
  21. ncbi Anesthesia of fish with benzocaine does not interfere with comet assay results
    Alisson Marques de Miranda Cabral Gontijo
    Departamento de Patologia, Faculdade de Medicina, UNESP, Botucatu, SP, Brazil
    Mutat Res 534:165-72. 2003
    ..we tested for a possible modulation of induced DNA damage (methyl methanesulfonate; MMS) by the anesthetic benzocaine administered by bath exposure (80mg/l for approximately 10min)...
  22. ncbi Benzocaine-induced methemoglobinemia based on the Mayo Clinic experience from 28 478 transesophageal echocardiograms: incidence, outcomes, and predisposing factors
    Garvan C Kane
    Echocardiography Laboratory, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Arch Intern Med 167:1977-82. 2007
    ..Acquired methemoglobinemia has been linked to the use of the topical anesthetic benzocaine in endoscopic procedures, including transesophageal echocardiography (TEE)...
  23. ncbi Benzocaine-induced methemoglobinemia during transesophageal echocardiography
    Sandra Kaye Birchem
    Mercy Medical Center North Iowa, Mason City, IA, USA
    J Am Osteopath Assoc 105:381-4. 2005
    ..This report describes a case of acquired methemoglobinemia that occurred after benzocaine spray was applied orally to a 69-year-old white woman weighing 175 lb who was undergoing transesophageal ..
  24. ncbi Granuloma gluteale adultorum associated with use of topical benzocaine preparations: case report and literature review
    Marlene T Dytoc
    Division of Dermatology and Cutaneous Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Cutan Med Surg 6:221-5. 2002
    ..Occlusion from diapers, paper napkins, plastic pants, detergents, starch, powder, halogenated steroids, candidal infection, and urine and feces are postulated as possible etiologies...
  25. ncbi A new validated method for the simultaneous determination of benzocaine, propylparaben and benzyl alcohol in a bioadhesive gel by HPLC
    P Pérez-Lozano
    Unit of Pharmaceutical Technology, Pharmacy and Pharmaceutical Technology Department, School of Pharmacy, University of Barcelona, Avda Joan XXIII s n 08028, Barcelona, Spain
    J Pharm Biomed Anal 39:920-7. 2005
    A new HPLC-RP method has been developed and validated for the simultaneous determination of benzocaine, two preservatives (propylparaben (nipasol) and benzyl alcohol) and degradation products of benzocaine in a semisolid pharmaceutical ..
  26. ncbi Topical benzocaine (Hurricaine) induced methemoglobinemia during endoscopic procedures in gastric bypass patients
    Myur S Srikanth
    Tacoma Surgical Weight Loss Clinic, Tacoma, WA 98418, USA
    Obes Surg 15:584-90. 2005
    ..It can be lethal if levels exceed 70%. Benzocaine 20% (Hurricaine) spray, commonly used in endoscopy (EGD) can cause methemoglobinemia. We report our experience.
  27. ncbi Potential for an external vaginal antiitch cream containing benzocaine to cause methemoglobinemia in healthy women
    J L Currie
    Department of Obstetrics and Gynecology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Obstet Gynecol 176:1006-8. 1997
    Our purpose was to assess the potential for an external vaginal antiitch cream (20% benzocaine, 3% resorcinol) to significantly increase levels of methemoglobin above normal in healthy women.
  28. pmc Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity
    Dorothy A Hanck
    Cardiology MC6094, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Circ Res 105:492-9. 2009
    ..A phenylalanine in domain IV, S6 (Phe1759 in Na(V)1.5), modeled to face the inner pore just below the selectivity filter, is critical in use-dependent drug block...
  29. ncbi A rare side effect of transesophageal echocardiography: methemoglobinemia from topical benzocaine anesthesia
    Zehra Jaffery
    Department of Internal Medicine, Heart and Vascular Institute, Henry Ford Hospital, 2799 West Grand Boulevard, K 14, Detroit, MI 48202, USA
    Eur J Echocardiogr 9:289-90. 2008
    b>Benzocaine induced methemoglobinemia is an uncommon, potentially fatal condition.
  30. ncbi A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels
    G K Wang
    Department of Anesthesia, Brigham and Women s Hospital, 75 Francis St Boston, MA 02115, USA
    Pflugers Arch 435:293-302. 1998
    According to Hille's modulated receptor hypothesis, benzocaine shares a common receptor with all other local anesthetics (LAs) in the voltage-gated Na+ channel...
  31. ncbi Topical anesthetic-induced methemoglobinemia and sulfhemoglobinemia in macaques: a comparison of benzocaine and lidocaine
    D G Martin
    Veterinary Medicine and Laboratory Resources Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5425, USA
    J Appl Toxicol 15:153-8. 1995
    b>Benzocaine (BNZ) and lidocaine (LC) are commonly used topical (spray) anesthetics approved for use in humans...
  32. pmc Binding of benzocaine in batrachotoxin-modified Na+ channels. State-dependent interactions
    G K Wang
    Department of Anesthesia, Harvard Medical School, Boston, Massachusetts 02115
    J Gen Physiol 103:501-18. 1994
    ..69:497-515) first proposed a modulated receptor hypothesis (MRH) to explain the action of benzocaine in voltage-gated Na+ channels...
  33. pmc Benzocaine-induced methemoglobinemia
    Frederick Hegedus
    Department of Oral and Maxillofacial Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA
    Anesth Prog 52:136-9. 2005
    ..The cause of methemoglobinemia was 20% benzocaine spray used for local anesthesia before intubation...
  34. pmc Clinical effectiveness of lidocaine and benzocaine for topical anesthesia
    A L Rosa
    Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirao Preto, University of Sao Paulo, Brazil
    Anesth Prog 46:97-9. 1999
    The effectiveness of lidocaine and benzocaine in reducing pain produced by needle insertion into the palate was evaluated in a double-blind and placebo-controlled study using a more suitable method...
  35. ncbi Local anesthetic block of batrachotoxin-resistant muscle Na+ channels
    G K Wang
    Department of Anesthesia, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Mol Pharmacol 54:389-96. 1998
    ..transfected human embryonic kidney 293T cells, and their sensitivity to lidocaine, QX-314, etidocaine, and benzocaine was assayed under whole-cell, voltage-clamp conditions...
  36. ncbi Methemoglobinemia induced by exposure to topical benzocaine for an awake nasal intubation--a case report
    Shih Kai Lin
    Department of Anesthesiology, Changhua Christian Hospital, Changhua, Taiwan, ROC
    Acta Anaesthesiol Taiwan 45:111-6. 2007
    Topical benzocaine and lidocaine are widely used in general anesthesia to minimize the stimulation by awake intubation and in very rare occasion they may induce methemoglobinemia...
  37. ncbi Evaluation of three topical anaesthetic agents against pain: a clinical study
    R Nayak
    Dept of Pedodontics and Preventive Dentistry, Manipal College of Dental Sciences, Mangalore
    Indian J Dent Res 17:155-60. 2006
    ..during local anaesthetic infiltration at bilateral buccal sites prepared with topical application of EMLA 5% cream, benzocaine 18% gel or lignocaine 5% ointment and also to find out the rapidity of onset of action of these agents.
  38. ncbi Methemoglobinemia: early intraoperative detection by clinical observation
    Leonard R Henry
    Section of Head and Neck Surgery, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Laryngoscope 114:2025-6. 2004
    ..b>Benzocaine (a component of many topical preparations) is frequently employed for this purpose...
  39. ncbi Topical anesthetic sprays directly associated with a serious, sometimes fatal adverse drug reaction: methemoglobinemia
    Susan Paparella
    Consulting Services, Institute for Safe Medication Practices, Huntingdon Valley, PA, USA
    J Emerg Nurs 31:468-9. 2005
  40. ncbi Reduction of pain from needle stick in the oral mucosa by topical anesthetics: a comparative study between lidocaine/prilocaine and benzocaine
    Manal Abu Al-Melh
    Faculty of Dentistry, Health Sciences Centre, Kuwait University, Kuwait
    J Clin Dent 16:53-6. 2005
    The aim of the study was to compare the analgesic effect of a topical benzocaine gel with that of a topical gel mixture of lidocaine/prilocaine (L/P).
  41. ncbi Acute methemoglobinemia after endoscopy
    Max Bayard
    Department of Family Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37604, USA
    J Am Board Fam Pract 17:227-9. 2004
  42. ncbi Avoiding topical anesthesia-induced methemoglobinemia
    David H Wong
    Obes Surg 15:1088. 2005
  43. ncbi Methemoglobinemia: sudden dyspnea and oxyhemoglobin desaturation after esophagoduodenoscopy
    Ellen Lunenfeld
    Department of Medicine, Jefferson Medical College, 1025 Walnut Street, 805, Philadelphia PA 19107, USA
    Respir Care 49:940-2. 2004
  44. ncbi Using the rapid response system to provide better oversight of patient care processes
    Michelle S Moore
    Department of Critical Care Medicine, Stanford University School of Medicine, CA, USA
    Jt Comm J Qual Patient Saf 33:695-8, 645. 2007
    ..The cross-disciplinary nature of patient care and medical emergency teams allows for identification of systemwide problems that might otherwise be perceived as isolated events...
  45. ncbi A PACU crisis: a case study on the development and management of methemoglobinemia
    Terri A Gray
    Providence Hospital, Southfield, MI 48037 2043, USA
    J Perianesth Nurs 19:242-53. 2004
    ..study describes the development, diagnosis, and management of a 63-year-old male scheduled for a laparoscopic cholecystectomy with an intraoperative cholangiogram who developed methemoglobinemia after benzocaine was given for intubation.
  46. ncbi A preliminary study of intra-pocket topical versus injected anaesthetic for scaling and root planing
    Jill L Stoltenberg
    Department of Primary Dental Care, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
    J Clin Periodontol 34:892-6. 2007
    Compare the efficacy of topical benzocaine gel to injected lidocaine during scaling and root planing.
  47. ncbi A wild reaction to a topical anesthetic
    Gwendolyn F Alonso
    East Pasco Medical Center, Zephyr Hills, FL, USA
    RN 68:57-60. 2005
  48. ncbi A cyanotic toddler
    Michael A Darracq
    Department of Emergency Medicine, University of California, Davis Medical Center, and California Poison Control System, Sacramento, CA, USA
    Pediatr Emerg Care 23:195-9. 2007
  49. ncbi Patch-test reactions to topical anesthetics: retrospective analysis of cross-sectional data, 2001 to 2004
    Erin M Warshaw
    Dermatitis 19:81-5. 2008
    Allergy to topical anesthetics is not uncommon. The cross-reactivity among topical anesthetics and the screening value of benzocaine alone are not well understood.
  50. ncbi Methemoglobinemia-induced cardio-respiratory failure secondary to topical anesthesia
    Sandeep A Saha
    Department of Medicine, The Chicago Medical School at Rosalind Franklin University of Medicine and Science and North Chicago VA Medical Center, North Chicago, IL 60064, USA
    Am J Ther 13:545-9. 2006
    Acute toxic methemoglobinemia is an infrequent complication of the use of topical anesthetics, most notably benzocaine. The clinical picture is characterized by sudden development of tissue hypoxia without underlying cardiac or ..
  51. ncbi Methemoglobinemia: hypotension and oxygen desaturation after transesophageal echocardiography
    Waheed Gul
    J Ark Med Soc 104:182-3. 2008
  52. ncbi [Comparison of the systems used for providing local anesthesia in dentistry--the Wand (Milestone Scientific) and Injex (Rosch)]
    Joanna Zarzecka
    Pracownia Stomatologii Zachowawczej z Endodoncja, Instytut Stomatologii Uniwersytetu Jagiellolńskiego Collegium Medicum, Krakow
    Przegl Lek 63:1304-9. 2006
    ..This procedure is very stressful for the patients because it is combined with pain. The new systems for delivering local anesthesia in dentistry have revolutionized the technique considerably by its simplify as well as reduction in pain...
  53. ncbi Cyanosis following transesophageal echocardiogram
    April M Lambert
    Department of Internal Medicine, James H Quillen College of Medicine, Johnson City, TN, USA
    W V Med J 104:10-5. 2008
    ..Because methemoglobinemia can be life-threatening, early recognition and treatment are extremely important...
  54. ncbi Methemoglobinemia after fiberoptic intubation in a patient with an unstable cervical fracture: a case report
    Sushil K Basra
    Department of Orthopaedics, University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ 07103, USA
    J Spinal Disord Tech 19:302-4. 2006
    ..Surgeons and anesthesiologists who manage such patients should be aware of methemoglobinemia, a rare but potentially fatal complication related to topical airway anesthetics...
  55. ncbi When brown and blue make red: a case of acquired methemoglobinemia
    Mark A Marinella
    Wright State University School of Medicine, Dayton, Ohio, USA
    Heart Lung 35:205-6. 2006
  56. ncbi Benzocaine-induced methemoglobinemia in two patients: interdisciplinary collaboration, management, and near misses
    Melinda J Throm
    Department of Pharmacy Practice, Midwestern University College of Pharmacy Glendale, Glendale, Arizona 85803, USA
    Pharmacotherapy 27:1206-14. 2007
    ..Methemoglobinemia develops in the presence of oxidizing agents, such as benzocaine-containing topical anesthetic sprays, and it is characterized by cyanosis...
  57. ncbi KNO3/benzocaine/tetracaine gel use for maintenance visit pain control
    Milton Hodosh
    Gen Dent 55:312-5. 2007
    A 35% potassium nitrate/20% benzocaine/10% tetracaine/aqueous hydroxyethyl cellulose gel was applied to the teeth and gingiva of 100 patients prior to hygienist-administered maintenance treatments...
  58. ncbi Methemoglobinemia after transesophageal echocardiography: a life-threatening complication
    Michael J Jacka
    Department of Anesthesiology, University of Alberta, Canada
    J Clin Anesth 18:52-4. 2006
    ..Treatment of acquired methemoglobinemia may require methylene blue, as oxygen is not usually sufficient. Avoidance of the oxidizing agent, probably benzocaine in the cases presented, is prudent.
  59. ncbi A nurse sends thanks for advice on treating a "wild reaction"
    Carol Gabella
    RN 69:12. 2006
  60. ncbi Death of an infant involving benzocaine
    Barry K Logan
    Washington State Toxicology Laboratory, Forensic Laboratory Services Bureau, Seattle 98134, USA
    J Forensic Sci 50:1486-8. 2005
    This report describes the death of a four-month-old Hispanic male which may be related to benzocaine toxicity. A toxicological evaluation revealed benzocaine at a concentration of 3.48 mg/L, and postmortem methemoglobin of 36% (normal 0...
  61. ncbi Double-blind study on the effects of topical anesthesia on laryngeal secretions
    Joy Walsh
    Beth Israel Deaconess Medical Center, Voice Speech Swallowing Service, Rehabilitation Services Department, Boston, Massachusetts, USA
    J Voice 20:282-90. 2006
    ..Speculation is entertained regarding possible physiological pathways for these incidental findings, which could be relevant for some clinical practice...
  62. ncbi Methemoglobinemia and transesophageal echo
    Marcelo A Jiminez
    Lenox Hill Hospital, New York, NY, 10021, USA
    Proc West Pharmacol Soc 50:134-5. 2007
    ..Though uncommon, MHb is the most Sported adverse event associated with topical benzocaine use. Untreated, it can lead to significant cardiopulmonary compromise, neurologic sequelae, and even death...
  63. ncbi More on benzocaine-induced methemoglobinemia
    Carol L St George
    J Am Osteopath Assoc 108:470. 2008
  64. ncbi Methemoglobinemia revisited: an important complication after transesophageal echocardiography
    Constantine Tsigrelis
    Department of Internal Medicine, UMDNJ Robert Wood Johnson Medical School, One Robert Wood Johnson Place, MEB 486, New Brunswick, NJ 08903, USA
    Eur J Echocardiogr 7:470-2. 2006
    Methemoglobinemia induced by the use of benzocaine-containing topical anesthetics is a rare, but potentially lethal complication after transesophageal echocardiography (TEE). We report a patient who developed methemoglobinemia after TEE...
  65. ncbi Comparison of topical anesthetics (EMLA/Oraqix vs. benzocaine) on pain experienced during palatal needle injection
    Manal Abu Al-Melh
    Department of Surgical Sciences, Faculty of Dentistry, Kuwait University, Safat, Kuwait
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:e16-20. 2007
    The aim of this study was to compare the topical anesthetic effect of 20% benzocaine gel with 2.5% lidocaine/2.5% prilocaine (L/P) cream and gel on the pain experienced during palatal anesthetic infiltration.
  66. ncbi Iatrogenic methemoglobinemia from benzocaine spray in trauma
    Todd L Allen
    Am J Emerg Med 22:226. 2004
  67. ncbi Suspected methemoglobinemia following awake intubation: one possible effect of benzocaine topical anesthesia--a case report
    Robert Sean Rinehart
    Fleet Surgical Team 2, Little Creek, VA, USA
    AANA J 71:117-8. 2003
    Methemoglobinemia is a potential negative side effect associated with the use of benzocaine for topical anesthesia...
  68. ncbi The use of lubricants to achieve tracheal intubation in neonates and infants
    Paul Picton
    Paediatr Anaesth 12:742. 2002
  69. ncbi Bye-bye benzocaine?
    Patricia Raymond
    Nursing 33:10. 2003
  70. pmc Should a mucoadhesive patch (DentiPatch) be used for gingival anesthesia in children?
    Shelly S Stecker
    Division of Oral and Maxillofacial Surgery, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Anesth Prog 49:3-8. 2002
    ..Topical anesthesia was provided using either the mucoadhesive patch (20% lidocaine) or topical anesthetic (20% benzocaine). Subjects were randomized using a split mouth model...
  71. ncbi Methemoglobinemia as a cause of respiratory failure
    Daniel R Margulies
    Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Trauma 52:796-7. 2002
  72. ncbi Severe methemoglobinemia after transesophageal echocardiography
    Vasundhara Vidyarthi
    Department of Cardiology, Mount Sinai Hospital, Chicago, IL 60608, USA
    Am J Ther 10:225-7. 2003
    ..This can cause hypoxia, cyanosis, or even death. Severe methemoglobinemia resulting from oral benzocaine spray before endoscopic procedures has been reported as a rare complication...
  73. ncbi Methemoglobinemia induced by topical benzocaine: a warning for the endoscopist
    H Y Abdallah
    Memorial Hospital of Rhode Island, Brown Medical School, Providence, Rhode Island, USA
    Endoscopy 34:730-4. 2002
    b>Benzocaine is used routinely for topical pharyngeal anesthesia prior to upper endoscopy, to improve patient tolerance. A potentially fatal, although often unrecognized, complication of benzocaine use is methemoglobinemia...
  74. ncbi Two cases of methemoglobinemia from the use of topical anesthetics
    Glenn Carlson
    Trauma Program, Bronson Methodist Hospital, 5863 Vista Ridge, Kalamazoo, MI 49009, USA
    J Emerg Nurs 29:106-8. 2003
  75. ncbi Methemoglobinemia and topical pharyngeal anesthesia
    Franz C Aepfelbacher
    N Engl J Med 348:85-6. 2003
  76. ncbi Effective topical anesthetic agents and techniques
    John G Meechan
    Department of Oral and Maxillofacial Surgery, Dental School, Framlington Place, Newcastle upon Tyne, NE2 4BW, United Kingdom
    Dent Clin North Am 46:759-66. 2002
    ..b>Benzocaine is effective when used alone at a concentration of 20% and when combined at a dose of 15% with 1.7% amethocaine...
  77. ncbi Perioperatively acquired methaemoglobinaemia in a preterm infant
    Cynthia A Voelker
    Department of Neonatology, Woman s Hospital, Baton Rouge, LA, USA
    Paediatr Anaesth 12:284-6. 2002
    ..Methaemoglobinaemia is an uncommon cause of neonatal cyanosis. A case that illustrates the aetiology, diagnosis, and treatment of this condition is presented...
  78. ncbi Influence of site preparation methods on the pain reported during palatal infiltration using the Wand Local Anesthetic System
    James Johnson
    Department of Pediatric Dentistry, College of Dentistry, University of Florida, P O Box 100426, Gainesville, FL 32610 8195, USA
    Am J Dent 16:165-9. 2003
    ....
  79. ncbi Children's preference of benzocaine gel versus the lidocaine patch
    Sonia J Wu
    Pediatric Dental Department, Lutheran Medical Center, Brooklyn, NY, USA
    Pediatr Dent 25:401-5. 2003
    This study compared pain, acceptance, and preference associated with 2 topical anesthetics: benzocaine gel and lidocaine patch (DentiPatch).
  80. ncbi Analgesic synergy between topical morphine and butamben in mice
    Yuri A Kolesnikov
    Department of Anesthesiology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Anesth Analg 97:1103-7, table of contents. 2003
    ..In the current studies, we demonstrate that topical butamben, benzocaine, and bupivacaine are active in the radiant heat tail-flick assay...
  81. ncbi The need for caution with topical anesthesia during endoscopic procedures, as liberal use may result in methemoglobinemia
    Michael F Byrne
    Division of Gastroenterology, Duke University Medical Center, Durham, NC, USA
    J Clin Gastroenterol 38:225-9. 2004
    During upper gastrointestinal endoscopy, topical oropharyngeal anesthesia with lidocaine and/or benzocaine is used routinely by many endodscopists...
  82. ncbi Respiratory failure secondary to methemoglobinemia induced by benzocaine: a case report
    Wissam I Khalife
    USD School of Medicine, Internal Medical Residency Program, Sioux Falls, SD, USA
    S D J Med 57:145-7. 2004
  83. ncbi Critical rebound methemoglobinemia after methylene blue treatment: case report
    Michael G Fitzsimons
    Harvard Medical School, Departments of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Pharmacotherapy 24:538-40. 2004
    A 39-year-old man developed significant methemoglobinemia after receiving benzocaine spray; he was treated appropriately with intravenous methylene blue...
  84. ncbi From cocaine to ropivacaine: the history of local anesthetic drugs
    Y A Ruetsch
    University of Zurich, Department of Anesthesiology, Orthopedic University Clinic Balgrist, Switzerland
    Curr Top Med Chem 1:175-82. 2001
    ..local anesthetics were synthesized between 1891 and 1930, such as tropocaine, eucaine, holocaine, orthoform, benzocaine, and tetracaine...
  85. ncbi Comparison of topical anesthetics and vasoconstrictors vs lubricants prior to nasogastric intubation: a randomized, controlled trial
    A J Singer
    Department of Emergency Medicine, State University of New York at Stony Brook, USA
    Acad Emerg Med 6:184-90. 1999
    ..To determine whether pre-treatment of the nose and throat with topical anesthetics and vasoconstrictors would reduce the pain associated with nasogastric (NG) intubation...
  86. doi Two cases of methemoglobinemia following zopiclone ingestion
    Hin Tat Fung
    Tuen Mun Hospital, Hong Kong, China
    Clin Toxicol (Phila) 46:167-70. 2008
    ..exposure to certain medications and chemicals such as nitrates, nitrites, aniline, dapsone, phenazopyridine, benzocaine, and chlorates which oxidize the iron from the ferrous state...
  87. ncbi A high prevalence of sensitization still persists in leg ulcer patients: a retrospective series of 106 patients tested between 2001 and 2002 and a meta-analysis of 1975-2003 data
    L Machet
    Service de Dermatologie, Centre Hospitalier Universitaire, Hopital Trousseau, 37044 Tours Cedex 1, France
    Br J Dermatol 150:929-35. 2004
    ..Sensitization to topical treatments used in leg ulcers is common. Questioning and patch testing are used to identify causative drugs or dressings...
  88. ncbi Contact allergy to lidocaine: a report of sixteen cases
    Antoine Amado
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Dermatitis 18:215-20. 2007
    ..5% and benzocaine 5% (1 case each)...
  89. ncbi Anogenital dermatitis in patients referred for patch testing: retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 1994-2004
    Erin M Warshaw
    Department of Dermatology, University of Minnesota, and Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Arch Dermatol 144:749-55. 2008
    ..To characterize patients with anogenital dermatitis referred for patch testing by the North American Contact Dermatitis Group, to identify common allergens, and to explore sex associations...
  90. doi High performance liquid chromatography-diode array and electrospray-mass spectrometry analysis of vardenafil, sildenafil, tadalafil, testosterone and local anesthetics in cosmetic creams sold on the Internet web sites
    Daniela De Orsi
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, V le Regina Elena 299, 00161, Rome, Italy
    J Pharm Biomed Anal 50:362-9. 2009
    ..for the determination of vardenafil, sildenafil, tadalafil, testosterone, procaine, lidocaine, prilocaine, and benzocaine in cosmetic creams sold as promising remedies for male erectile dysfunction and female genitals stimulation...
  91. ncbi Active transport inhibition in rat small intestine by amphiphilic amines: an in vitro study with various local anaesthetics
    G J Strugala
    Walther Straub Institut für Pharmakologie und Toxikologie, Ludwig Maximilians Universitat Munchen, D 80336, Munchen, Germany
    Biochem Pharmacol 59:907-13. 2000
    ..All the amphiphilic amines tested, except for benzocaine, significantly inhibited Na(+)-dependent active uptake of methyl alpha-D-glucoside and L-leucine while leaving ..
  92. ncbi Patch testing with the irritant sodium lauryl sulfate (SLS) is useful in interpreting weak reactions to contact allergens as allergic or irritant
    J Geier
    Information Network of Departments of Dermatology IVDK, Georg August University, Department of Dermatology, Gottingen, Germany
    Contact Dermatitis 48:99-107. 2003
    ..alcohol, 4-phenylenediamine base (PPD), propolis, formaldehyde, N-isopropyl-N'-phenyl-p-phenylenediamine (IPPD), benzocaine, and 4-tert-butylphenol-formaldehyde resin...
  93. doi A study of the thermal decomposition of adulterated cocaine samples under optimized aerobic pyrolytic conditions
    T Gostic
    Ministry of the Interior, Forensic Research Center, Vodovodna 95, 1000 Ljubljana, Slovenia
    Forensic Sci Int 187:19-28. 2009
    ..The anaesthetics lidocaine, benzocaine, procaine, the analgesics phenacetine and paracetamol, and the stimulant caffeine were used as the adulterants...
  94. ncbi Efficacy of a mucoadhesive patch compared with an oral solution for treatment of aphthous stomatitis
    Avner Shemer
    Department of Dermatology, C Sheba Medical Center, Ramat Gan, Israel
    Drugs R D 9:29-35. 2008
    ..The purpose of this study was to evaluate the efficacy and tolerability of a mucoadhesive patch compared with a pain-relieving oral solution for the treatment of aphthous stomatitis...
  95. ncbi Allergic contact dermatitis to topical drugs--epidemiological risk assessment
    C A Menezes de Pádua
    Department of Medical Informatics, Biometry and Epidemiology, Friedrich Alexander University, Erlangen, Germany
    Pharmacoepidemiol Drug Saf 17:813-21. 2008
    ....
  96. ncbi Analysis of carbohydrates in wood and pulps employing enzymatic hydrolysis and subsequent capillary zone electrophoresis
    O Dahlman
    Swedish Pulp and Paper Research Institute, Stockholm
    J Chromatogr A 891:157-74. 2000
    ..e., 30 h incubation at pH 4 and 40 degrees C); whereas mixtures of HexA-xylobiose and HexA-xylotriose were obtained when the incubation was performed at pH 5 or 6...
  97. pmc Contact dermatitis in students practicing sports: incidence of rubber sensitisation
    M T Ventura
    Department of Internal Medicine, Immunology and Infectious Disease, University of Bari Medical School, Policlinico, Bari, Italy
    Br J Sports Med 35:100-2. 2001
    ....
  98. ncbi Development and application of a capillary electrophoresis based method for the assessment of monosaccharide in soil using acid hydrolysis
    Sérgio M Santos
    CESAM and Department of Chemistry, University of Aveiro, Aveiro, Portugal
    Talanta 72:165-71. 2007
    ..0045+/-0.0003% (glucose) and 0.0267+/-0.0002% (arabinose) of the total soil content. Xylose, rhamnose, mannose, fucose and galactose content were also studied in the present work...
  99. ncbi (19)F NMR spectroscopic characterization of the interaction of niflumic acid with human serum albumin
    Keisuke Kitamura
    Kyoto Pharmaceutical University, 5 Nakauchicho, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Anal Bioanal Chem 387:2843-8. 2007
    ..Competitive (19)F NMR experiments using warfarin, dansyl-L: -asparagine, and benzocaine (site I ligands), and L: -tryptophan and ibuprofen (site II ligands) revealed that NFA binds to site I at two ..
  100. ncbi Infection and the risk of topical anesthetic induced clinically significant methemoglobinemia after transesophageal echocardiography
    Srikanth Vallurupalli
    Division of General Internal Medicine, Department of Medicine, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Echocardiography 27:318-23. 2010
    Methemoglobinemia is a recognized complication of topical anesthesia with benzocaine during transesophageal echocardiography (TEE). Though several risk factors have been described, the importance of individual factors is not known...
  101. ncbi The association between ambient air conditions (temperature and absolute humidity), irritant sodium lauryl sulfate patch test reactions and patch test reactivity to standard allergens
    Wolfgang Uter
    Department of Medical Informatics, Biometry and Epidemiology IMBE, University of Erlangen Nurnberg, Erlangen, Germany
    Contact Dermatitis 49:97-102. 2003
    ..with dry/cold weather conditions, but not with SLS reactivity, the opposite was observed for lanolin alcohol, benzocaine and Myroxylon pereirae resin (balsam of Peru)...

Research Grants36

  1. CARDIAC CHANNELS--TARGETS OF DRUGS THAT AFFECT KINETICS
    DOROTHY HANCK; Fiscal Year: 2003
    ..In addition, experiments are proposed that will establish the channel specific or common effects on kinetics that control the action and efficacy of these agents as therapeutic drugs. ..
  2. DRUG INTERACTIONS WITH MODIFIED CARDIAC ION CHANNELS
    Jonathan Makielski; Fiscal Year: 1999
    ..We will first refine a protocol for the components of LA block using prototype charged (QX-222), uncharged (benzocaine), and mixed charge (lidocaine) LA (Aim 1)...
  3. Hispanic Heroin Users, Transitions to Injecting and HIV
    Avelardo Valdez; Fiscal Year: 2005
    ....
  4. Substance Use and Other Health Consequences Among Katrina Evacuees in Houston
    Avelardo Valdez; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  5. Cardiac Channels: Targets of Drugs that Affect Kinetics
    DOROTHY HANCK; Fiscal Year: 2007
    ..Our strategy combines mutagenesis, whole cell, single channel, and gating current electrophysiology, and molecular modeling. ..
  6. Substance Use and Other Health Consequences Among Katrina Evacuees in Houston
    Avelardo Valdez; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. Cardiac Channels: Targets of Drugs that Affect Kinetics
    DOROTHY HANCK; Fiscal Year: 2008
    ..Our strategy combines mutagenesis, whole cell, single channel, and gating current electrophysiology, and molecular modeling. ..
  8. STRUCTURE-FUNCTION OF THE CARDIAC SODIUM CHANNEL
    DOROTHY HANCK; Fiscal Year: 2008
    ..abstract_text> ..
  9. Substance Use and Other Health Consequences Among Katrina Evacuees in Houston
    Avelardo Valdez; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. University of Houston Drug Abuse Research Development Program
    Avelardo Valdez; Fiscal Year: 2008
    ..The second pilot will use a "network facilitation" model and focus on the extent to which social networks facilitate (or impede) injecting drug use and related risk behaviors (N=60). ..
  11. Cardiac Channels: Targets of Drugs that Affect Kinetics
    DOROTHY HANCK; Fiscal Year: 2009
    ..Our strategy combines mutagenesis, whole cell, single channel, and gating current electrophysiology, and molecular modeling. ..
  12. Substance Use and Other Health Consequences Among Katrina Evacuees in Houston
    Avelardo Valdez; Fiscal Year: 2008
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page -| Description, ..
  13. At Risk Hispanic Gangs: Long-Term Consequences for Hiv, Hepatitis and STI
    Avelardo Valdez; Fiscal Year: 2008
    ..Findings from this study can be used to develop HIV intervention strategies culturally appropriate for high risk Mexican American young adult populations ..
  14. Drug therapy targeted to the voltage-gated sodium channel
    DOROTHY HANCK; Fiscal Year: 2009
    ..In pursuance of this hypothesis we will determine the residues at the bundle crossing by crosslinking Cys substitutions between S6 segments. ..
  15. At Risk Hispanic Gangs: Long-Term Consequences for Hiv, Hepatitis and STI
    Avelardo Valdez; Fiscal Year: 2009
    ..Findings from this study can be used to develop HIV intervention strategies culturally appropriate for high risk Mexican American young adult populations ..
  16. Cardiac Channels: Targets of Drugs that Affect Kinetics
    Dorothy A Hanck; Fiscal Year: 2010
    ..Our strategy combines mutagenesis, whole cell, single channel, and gating current electrophysiology, and molecular modeling. ..
  17. Cardiac Channels: Targets of Drugs that Affect Kinetics
    DOROTHY HANCK; Fiscal Year: 2009
    ..Our strategy combines mutagenesis, whole cell, single channel, and gating current electrophysiology, and molecular modeling. ..
  18. At Risk Hispanic Gangs: Long-Term Consequences for Hiv, Hepatitis and STI
    AVELARDO contact VALDEZ; Fiscal Year: 2010
    ..Findings from this study can be used to develop HIV intervention strategies culturally appropriate for high risk Mexican American young adult populations ..
  19. University of Houston Drug Abuse Research Development Program
    Avelardo Valdez; Fiscal Year: 2007
    ..The second pilot will use a "network facilitation" model and focus on the extent to which social networks facilitate (or impede) injecting drug use and related risk behaviors (N=60). ..
  20. STRUCTURAL BASES OF T-TYPE CALCIUM CHANNEL FUNCTION
    DOROTHY HANCK; Fiscal Year: 2000
    ..These experiments will use techniques of electrophysiology, mutagenesis and molecular modeling. ..
  21. STRUCTURAL BASES OF T-TYPE CALCIUM CHANNEL FUNCTION
    DOROTHY HANCK; Fiscal Year: 2001
    ..These experiments will use techniques of electrophysiology, mutagenesis and molecular modeling. ..
  22. CARDIAC CHANNELS--TARGETS OF DRUGS THAT AFFECT KINETICS
    DOROTHY HANCK; Fiscal Year: 2001
    ..In addition, experiments are proposed that will establish the channel specific or common effects on kinetics that control the action and efficacy of these agents as therapeutic drugs. ..
  23. Hispanic Heroin Users, Transitions to Injecting and HIV
    Avelardo Valdez; Fiscal Year: 2002
    ....
  24. STRUCTURAL BASES OF T-TYPE CALCIUM CHANNEL FUNCTION
    DOROTHY HANCK; Fiscal Year: 2002
    ..These experiments will use techniques of electrophysiology, mutagenesis and molecular modeling. ..
  25. CARDIAC CHANNELS--TARGETS OF DRUGS THAT AFFECT KINETICS
    DOROTHY HANCK; Fiscal Year: 2002
    ..In addition, experiments are proposed that will establish the channel specific or common effects on kinetics that control the action and efficacy of these agents as therapeutic drugs. ..
  26. Hispanic Heroin Users, Transitions to Injecting and HIV
    Avelardo Valdez; Fiscal Year: 2001
    ....
  27. STRUCTURAL BASES OF T-TYPE CALCIUM CHANNEL FUNCTION
    DOROTHY HANCK; Fiscal Year: 2003
    ..These experiments will use techniques of electrophysiology, mutagenesis and molecular modeling. ..
  28. Hispanic Heroin Users, Transitions to Injecting and HIV
    Avelardo Valdez; Fiscal Year: 2003
    ....
  29. GENETIC POLYMORPHISMS IN THE EPOXYGENASE PATHWAY IN HYPERTENSION
    Albert Dreisbach; Fiscal Year: 2002
    ..abstract_text> ..
  30. STRUCTURAL BASES OF T-TYPE CALCIUM CHANNEL FUNCTION
    DOROTHY HANCK; Fiscal Year: 2003
    ..These experiments will use techniques of electrophysiology, mutagenesis and molecular modeling. ..
  31. CARDIAC NA+ CHANNEL GATING AND LOCAL ANESTHETIC BLOCK
    STERLING WRIGHT; Fiscal Year: 2004
    ..abstract_text> ..
  32. Children's Reasoning About Anxiety Sensations
    Carl Weems; Fiscal Year: 2004
    ..The third and final aim is to explore possible developmental differences in children's reasoning about anxiety sensations. ..
  33. Hispanic Heroin Users, Transitions to Injecting and HIV
    Avelardo Valdez; Fiscal Year: 2004
    ....
  34. Hispanic Heroin Users, Transitions to Injecting and HIV
    Avelardo Valdez; Fiscal Year: 2005
    ....
  35. Drug therapy targeted to the voltage-gated sodium channel
    Michael F Sheets; Fiscal Year: 2010
    ..In pursuance of this hypothesis we will determine the residues at the bundle crossing by crosslinking Cys substitutions between S6 segments. ..