propionic acids

Summary

Summary: 3-carbon saturated monocarboxylic acids.

Top Publications

  1. pmc AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
    Haihong Zong
    Howard Hughes Medical Institute and the Departments of Internal Medicine, Cell Biology, and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 99:15983-7. 2002
  2. ncbi 3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease
    Emmanuel Brouillet
    Centre Nationale de la Recherche Scientifique 2210, Service Hospitalier Frederic Joliot, Départment de Recherches Médicales, Direction des Sciences du Vivant, CEA, Orsay France
    J Neurochem 95:1521-40. 2005
  3. pmc Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1
    Meihua Luo
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA
    Antioxid Redox Signal 10:1853-67. 2008
  4. pmc Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration
    Gang Ming Zou
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB 2, M341, Baltimore, MD 21231, USA
    Mol Cancer Ther 7:2012-21. 2008
  5. pmc Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence
    Ernesto J Muñoz-Elías
    Laboratory of Infection Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Nat Med 11:638-44. 2005
  6. ncbi Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders
    Derrick F MacFabe
    The Kilee Patchell Evans Autism Research Group, Department of Psychology, Division of Developmental Disabilities, University of Western Ontario, Social Science Centre, London, Canada
    Behav Brain Res 176:149-69. 2007
  7. ncbi Synthesis, antimicrobial, and anti-inflammatory activities of novel 2-[3-(1-adamantyl)-4-substituted-5-thioxo-1,2,4-triazolin-1-yl] acetic acids, 2-[3-(1-adamantyl)-4-substituted-5-thioxo-1,2,4-triazolin-1-yl]propionic acids and related derivatives
    Omar A Al-Deeb
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Arzneimittelforschung 56:40-7. 2006
  8. pmc Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation
    Rajnish K Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Hum Mol Genet 19:3190-205. 2010
  9. ncbi Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain
    Gang Ming Zou
    Department of Pediatrics Section of Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 109:1917-22. 2007
  10. ncbi Cyclooxygenases, thromboxane, and atherosclerosis: plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonism
    Karine M Egan
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Circulation 111:334-42. 2005

Detail Information

Publications207 found, 100 shown here

  1. pmc AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
    Haihong Zong
    Howard Hughes Medical Institute and the Departments of Internal Medicine, Cell Biology, and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 99:15983-7. 2002
    ..These data demonstrate that by sensing the energy status of the muscle cell, AMPK is a critical regulator involved in initiating mitochondrial biogenesis...
  2. ncbi 3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease
    Emmanuel Brouillet
    Centre Nationale de la Recherche Scientifique 2210, Service Hospitalier Frederic Joliot, Départment de Recherches Médicales, Direction des Sciences du Vivant, CEA, Orsay France
    J Neurochem 95:1521-40. 2005
    ..Research on 3NP provides additional proof that the neurochemical environment of a given neurone can determine its preferential vulnerability in neurodegenerative diseases...
  3. pmc Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1
    Meihua Luo
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA
    Antioxid Redox Signal 10:1853-67. 2008
    ..Here we discuss small-molecule inhibition of Ape1 redox and its effect on both cancer and endothelial cells...
  4. pmc Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration
    Gang Ming Zou
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB 2, M341, Baltimore, MD 21231, USA
    Mol Cancer Ther 7:2012-21. 2008
    ..Inhibition of the APE1 redox function through pharmacologic means has the potential to become a promising therapeutic strategy in this disease...
  5. pmc Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence
    Ernesto J Muñoz-Elías
    Laboratory of Infection Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Nat Med 11:638-44. 2005
    ..tuberculosis on fatty acids and in macrophages. The absence of ICL orthologs in mammals should facilitate the development of glyoxylate cycle inhibitors as new drugs for the treatment of tuberculosis...
  6. ncbi Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders
    Derrick F MacFabe
    The Kilee Patchell Evans Autism Research Group, Department of Psychology, Division of Developmental Disabilities, University of Western Ontario, Social Science Centre, London, Canada
    Behav Brain Res 176:149-69. 2007
    ..Thus, intraventricular administration of PPA in rats may provide a means to model some aspects of human ASD in rats...
  7. ncbi Synthesis, antimicrobial, and anti-inflammatory activities of novel 2-[3-(1-adamantyl)-4-substituted-5-thioxo-1,2,4-triazolin-1-yl] acetic acids, 2-[3-(1-adamantyl)-4-substituted-5-thioxo-1,2,4-triazolin-1-yl]propionic acids and related derivatives
    Omar A Al-Deeb
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Arzneimittelforschung 56:40-7. 2006
    ..Compounds 4a, 4b, 4e, 4f, 6f, 6g and 10 produced good dose-dependent anti-inflammatory activities...
  8. pmc Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation
    Rajnish K Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Hum Mol Genet 19:3190-205. 2010
    ....
  9. ncbi Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain
    Gang Ming Zou
    Department of Pediatrics Section of Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 109:1917-22. 2007
    ..In summary, these data indicate Ape1 is required in normal embryonic hematopoiesis and that the redox function, but not the repair endonuclease activity, of Ape1 is critical in normal embryonic hematopoietic development...
  10. ncbi Cyclooxygenases, thromboxane, and atherosclerosis: plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonism
    Karine M Egan
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Circulation 111:334-42. 2005
    ..We addressed this issue and the role of TxA2 in the promotion and regression of diffuse, established atherosclerosis in Apobec-1/LDLR double KOs (DKOs)...
  11. ncbi Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid
    Gyung W Kim
    Department of Neurosurgery, Stanford University School of Medicine, California 94305 5487, USA
    J Cereb Blood Flow Metab 22:798-809. 2002
    ..001). These data suggest that production of superoxide may be a critical step to excitotoxicity and subsequent DNA fragmentation in selective striatal vulnerability after 3-NP treatment...
  12. pmc Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1
    Mark R Kelley
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 980 West Walnut Street, Indianapolis, IN 46202, USA
    Antioxid Redox Signal 14:1387-401. 2011
    ..This progress in synthesizing and isolating biologically active novel E3330 analogues that effectively inhibit the APE1 redox function validates the utility of further translational anticancer therapeutic development...
  13. ncbi Mitochondrial calcium, oxidative stress and apoptosis in a neurodegenerative disease model induced by 3-nitropropionic acid
    T R Rosenstock
    Departamento de Farmacologia, Universidade Federal de Sao Paulo UNIFESP EPM, Sao Paulo, Brazil
    J Neurochem 88:1220-8. 2004
    ..Taken together, our results show that complex II inhibition could involve Ca2+m release, oxidative stress and cell death that may precede motor alterations in neurodegenerative processes such as HD...
  14. pmc High-resolution crystal structure of deoxy hemoglobin complexed with a potent allosteric effector
    M K Safo
    Department of Medicinal Chemistry, School of Pharmacy and Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia 23298-0540, USA
    Protein Sci 10:951-7. 2001
    ..A detailed structural analysis of this compound complexed with deoxy Hb has important implications for the rational design of future analogs...
  15. ncbi Improved endothelial function by the thromboxane A2 receptor antagonist S 18886 in patients with coronary artery disease treated with aspirin
    Laurent Belhassen
    Service de Physiologie Explorations Fonctionnelles et Fédération de Cardiologie, CHU Henri Mondor, AP HP, Creteil, France
    J Am Coll Cardiol 41:1198-204. 2003
    ..In this study, we evaluated the effect of S 18886, a specific thromboxane A(2) receptor antagonist, on endothelial function in patients with coronary artery disease (CAD)...
  16. pmc Graminicide insensitivity correlates with herbicide-binding co-operativity on acetyl-CoA carboxylase isoforms
    Lindsey J Price
    School of Biosciences, Cardiff University, P O Box 911, Cardiff CF10 3US, UK
    Biochem J 375:415-23. 2003
    ....
  17. ncbi Effect of dietary formic and propionic acids on salmonella pullorum shedding and mortality in layer chicks after experimental infection
    Y H Al-Tarazi
    Department of Basic Medical Veterinary Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology JUST, PO Box 3030, Irbid, Jordan
    J Vet Med B Infect Dis Vet Public Health 50:112-7. 2003
    ..pullorum and significantly decreases S. pullorum faecal excretion and reduced the chick mortality rate...
  18. ncbi Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder
    Derrick F MacFabe
    The Kilee Patchell Evans Autism Research Group, Department of Psychology, Division of Developmental Disabilities, University of Western Ontario, London, Canada
    Behav Brain Res 217:47-54. 2011
    ....
  19. ncbi Role of prostacyclin in the cardiovascular response to thromboxane A2
    Yan Cheng
    Center for Experimental Therapeutics, 153 Johnson Pavilion, 3620 Hamilton Walk, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    Science 296:539-41. 2002
    ..This interplay may help explain the adverse cardiovascular effects associated with selective COX-2 inhibitors, which, unlike aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), inhibit PGI2 but not TxA2...
  20. ncbi Age-associated changes in SAPK/JNK and p38 MAPK signaling in response to the generation of ROS by 3-nitropropionic acid
    Ching Chyuan Hsieh
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 613 Basic Science Building, Rt 0643, Galveston, TX 77555 0643, USA
    Mech Ageing Dev 124:733-46. 2003
    ....
  21. ncbi Inhibition of mitochondrial complex II induces a long-term potentiation of NMDA-mediated synaptic excitation in the striatum requiring endogenous dopamine
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, , Rome 00133, Italy
    J Neurosci 21:5110-20. 2001
    ..Thus 3-NP-LTP might play a key role in the regional and cell type-specific neuronal death observed in HD...
  22. ncbi DX-9065a inhibition of factor Xa and the prothrombinase complex: mechanism of inhibition and comparison with therapeutic heparins
    Alireza R Rezaie
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri, USA
    Thromb Haemost 89:112-21. 2003
    ..Further studies revealed that Tyr(99), a residue in the extended S2-S4 binding pocket of fXa, plays a key role in determination of specificity of the DX-9065a interaction...
  23. ncbi Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. I. Effects on thrombin generation
    Hajime Nagashima
    New Product Research Laboratories II, Daiichi Pharmaceutical Co, Ltd, Tokyo 104 8369, Japan
    J Biol Chem 277:50439-44. 2002
    ..This study demonstrates differential inhibition of thrombin generation by fXa and thrombin inhibitors and has implications for the pharmacological regulation of blood coagulation by the anticoagulant protease inhibitors...
  24. ncbi Batch fermentation model of propionic acid production by Propionibacterium acidipropionici in different carbon sources
    Jefferson Coral
    Biotechnology and Bioprocess Engineering Division, Federal University of Parana, 81531 970, Curitiba, Parana, Brazil
    Appl Biochem Biotechnol 151:333-41. 2008
    ..724 g g(-1)) because there was no detection of acetic acid. By the way, when using the other two carbon sources, acetic acid emerged as an undesirable by-product for further PA purification...
  25. pmc HIF prolyl hydroxylase inhibitors prevent neuronal death induced by mitochondrial toxins: therapeutic implications for Huntington's disease and Alzheimer's disease
    Zoya Niatsetskaya
    Burke Cornell Medical Research Institute, White Plains, New York 10605, USA
    Antioxid Redox Signal 12:435-43. 2010
    ....
  26. ncbi 3-Nitropropionic acid depresses spinal reflexes involving GABAergic and glycinergic transmission in neonatal rat spinal cord in vitro
    Rajesh Gupta
    Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, UP, India
    Life Sci 83:756-60. 2008
    ..The present study was conducted to identify the involvement of inhibitory system in 3-NPA-induced depression of spinal reflexes...
  27. ncbi The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E-deficient mice: evidence that eicosanoids other than thromboxane contribute to atherosclerosis
    A J Cayatte
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, MA 02118, USA
    Arterioscler Thromb Vasc Biol 20:1724-8. 2000
    ....
  28. ncbi Global anticoagulant effects of a synthetic anti-factor Xa inhibitor (DX-9065a): implications for interventional use
    Mahmut Tobu
    Department of Pathology and Pharmacology, Loyola University, Maywood, Illinois, USA
    Clin Appl Thromb Hemost 9:1-17. 2003
    ..DX-9065a did not affect the ecarin clotting time and thrombin time at concentrations up to 12.5 microgram/mL. Because DX-9065a prolonged the dRVVT, this may impact diagnostic screening of patients with systemic lupus erythematosus...
  29. ncbi Clinical and experimental studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analogue, in heart failure
    Eugene Morkin
    Department of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    Thyroid 12:527-33. 2002
    ..Total serum cholesterol (p = 0.013) and triglycerides (p = 0.005) also were decreased significantly. These results indicate that DITPA is well tolerated and could represent a useful new agent for treatment of congestive heart failure...
  30. ncbi Proangiogenesis action of the thyroid hormone analog 3,5-diiodothyropropionic acid (DITPA) is initiated at the cell surface and is integrin mediated
    Shaker A Mousa
    The Pharmaceutical Research Institute and Albany College of Pharmacy, New York 12208, USA
    Endocrinology 147:1602-7. 2006
    ..Thus, the proangiogenesis actions of thyroid hormone and its analog DITPA are initiated at the plasma membrane, apparently at integrin alphavbeta3, and are MAPK dependent...
  31. pmc Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival
    Junghee Lee
    Neurology Department, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 280:40398-401. 2005
    ....
  32. ncbi A phase I study of RSR13, a radiation-enhancing hemoglobin modifier: tolerance of repeated intravenous doses and correlation of pharmacokinetics with pharmacodynamics
    B D Kavanagh
    Department of Radiation Oncology, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0058, USA
    Int J Radiat Oncol Biol Phys 49:1133-9. 2001
    ....
  33. ncbi Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice
    Robert J Ferrante
    Geriatric Research Education and Clinical Center, Bedford Veterans Affairs Medical Center, Bedford, Massachusetts 01730, USA
    J Neurosci 23:9418-27. 2003
    ....
  34. ncbi Mice overexpressing 70-kDa heat shock protein show increased resistance to malonate and 3-nitropropionic acid
    Alpaslan Dedeoglu
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Exp Neurol 176:262-5. 2002
    ..These findings support the idea that HSP-70 has a neuroprotective role that may be useful in the treatment of neurodegenerative diseases...
  35. ncbi Synthetic selective inhibitors of coagulation factor Xa strongly inhibit thrombin generation without affecting initial thrombin forming time necessary for platelet activation in hemostasis
    M Ieko
    Departments of Internal Medicine, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido, Japan
    J Thromb Haemost 2:612-8. 2004
    ....
  36. ncbi Enhanced propionic acid fermentation by Propionibacterium acidipropionici mutant obtained by adaptation in a fibrous-bed bioreactor
    Supaporn Suwannakham
    Department of Chemical and Biomolecular Engineering, The Ohio State University, 140 West 19th Avenue, Columbus, Ohio 43210, USA
    Biotechnol Bioeng 91:325-37. 2005
    ..acidipropionici was thus attributed to both a high viable cell density maintained in the reactor and favorable mutations resulted from adaptation by cell immobilization in the FBB...
  37. ncbi First experience with direct, selective factor Xa inhibition in patients with non-ST-elevation acute coronary syndromes: results of the XaNADU-ACS Trial
    J H Alexander
    Duke University Center and Duke Clinical Research Institute, Durham, NC 27715, USA
    J Thromb Haemost 3:439-47. 2005
    ..Anticoagulants with predictable kinetics and anticoagulant effects, better efficacy, and greater safety are needed...
  38. ncbi Engineering Propionibacterium acidipropionici for enhanced propionic acid tolerance and fermentation
    An Zhang
    William G Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 140 West 19th Avenue, Columbus, Ohio 43210, USA
    Biotechnol Bioeng 104:766-73. 2009
    ..The adapted mutant obtained from the FBB showed significantly reduced growth sensitivity to propionic acid inhibition, increased H+-ATPase expression and activity, and significantly elongated rod morphology...
  39. ncbi Impaired mitochondrial function results in increased tissue transglutaminase activity in situ
    M Lesort
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Neurochem 75:1951-61. 2000
    ..This study demonstrates for the first time that impairment of mitochondrial function significantly increases TG activity in situ, a finding that may have important relevance to the etiology of HD...
  40. pmc Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle
    A R Horswill
    Department of Bacteriology, University of Wisconsin Madison, Madison, Wisconsin 53706 1567, USA
    J Bacteriol 181:5615-23. 1999
    ..Although PrpC could use acetyl-CoA as a substrate to synthesize citrate, kinetic analysis demonstrated that propionyl-CoA is the preferred substrate...
  41. ncbi Decrease in plasma concentrations of antiangiogenic agent TSU-68 ((Z)-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid) during oral administration twice a day to rats
    Ryuichi Kitamura
    Pharmacokinetics Research Laboratory, Taiho Pharmaceutical Co, Ltd, 224 2, Ebisuno, Hiraishi, Kawauchicho, Tokushima 771 0194, Japan
    Drug Metab Dispos 35:1611-6. 2007
    ..e., autoinduction). In conclusion, the decrease in plasma concentrations of TSU-68 during the administration twice a day to rats was due to the rapid autoinduction. The same mechanism is probably at work in the clinical setting...
  42. ncbi Antioxidant effects of taurine, vitamin C, and vitamin E on oxidative damage in hippocampus caused by the administration of 3-nitropropionic acid in rats
    Erika Rodríguez-Martínez
    Departamento de Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma, de México, Mexico
    Int J Neurosci 114:1133-45. 2004
    ..Administration of taurine, vitamin C, and vitamin E partially protected from oxidative damage, indicate that while all substances had antioxidant effects, only taurine showed morphological protection in surviving cells...
  43. ncbi D-beta-hydroxybutyrate protects dopaminergic SH-SY5Y cells in a rotenone model of Parkinson's disease
    Keiko Imamura
    Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan
    J Neurosci Res 84:1376-84. 2006
    ..Ketone bodies, the alternative energy source in the mammalian brain, appear to have therapeutic potential in PD...
  44. ncbi Identification of human liver cytochrome P450 isoforms involved in autoinduced metabolism of the antiangiogenic agent (Z)-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid (TSU-68)
    Ryuichi Kitamura
    Pharmacokinetics Research Laboratory, Taiho Pharmaceutical Co, Ltd, 224 2, Ebisuno, Hiraishi, Kawauchi cho, Tokushima 771 0194, Japan
    Drug Metab Dispos 36:1003-9. 2008
    ..This autoinductive effect provides a clear explanation for the clinically observed decrease in TSU-68 plasma concentrations during repeated administration of the drug...
  45. ncbi Mapping extracellular pH in rat brain gliomas in vivo by 1H magnetic resonance spectroscopic imaging: comparison with maps of metabolites
    M L García-Martín
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, 28029 Madrid, Spain
    Cancer Res 61:6524-31. 2001
    ..These results suggest that lactate is produced mainly in viable, well-perfused, tumoral tissue from which proton equivalents are rapidly cleared...
  46. ncbi Survival of patients with newly diagnosed glioblastoma multiforme treated with RSR13 and radiotherapy: results of a phase II new approaches to brain tumor therapy CNS consortium safety and efficacy study
    L Kleinberg
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 2410, USA
    J Clin Oncol 20:3149-55. 2002
    ..RSR13, a synthetic allosteric modifier of hemoglobin, is a radiation-enhancing agent that noncovalently binds to hemoglobin, reduces oxygen-binding affinity, and increases oxygen unloading to hypoxic tissue...
  47. ncbi 3-Nitropropionic acid toxicity in hippocampus: protection through N-methyl-D-aspartate receptor antagonism
    David A Karanian
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269 3092, USA
    Hippocampus 16:834-42. 2006
    ..They also provide further evidence of memantine's therapeutic potential against neurodegenerative diseases...
  48. ncbi Oxidative stress and neuronal DNA fragmentation mediate age-dependent vulnerability to the mitochondrial toxin, 3-nitropropionic acid, in the mouse striatum
    G W Kim
    Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, California, USA
    Neurobiol Dis 8:114-26. 2001
    ..Therefore, these results suggest that oxidative stress induces age-dependent neuronal apoptosis in the mouse striatum after 3-NP treatment, which in turn produces an age-dependent vulnerability to 3-NP...
  49. ncbi Biodegradable polymers from organic acids by using activated sludge enriched by aerobic periodic feeding
    Davide Dionisi
    Department of Chemistry, University of Rome La Sapienza, P le Aldo Moro 5, 00185, Rome, Italy
    Biotechnol Bioeng 85:569-79. 2004
    ..A concentrated mixture of acetic, lactic, and propionic acids (overall concentration of 8.5 gCOD L(-1)) was fed every 2 h at 1 day(-1) overall dilution rate...
  50. ncbi Striatal cells from mutant huntingtin knock-in mice are selectively vulnerable to mitochondrial complex II inhibitor-induced cell death through a non-apoptotic pathway
    Qingmin Ruan
    Department of Psychiatry, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Hum Mol Genet 13:669-81. 2004
    ..These findings suggest that impaired mitochondrial complex II function in HD may contribute to non-apoptotic neuronal cell death...
  51. ncbi Death of cortical and striatal neurons induced by mitochondrial defect involves differential molecular mechanisms
    Marie Christine Galas
    Laboratoire de Neurophysiologie, ULB Erasme, 1070 Brussels, Belgium
    Neurobiol Dis 15:152-9. 2004
    ..This suggests that mitochondrial defects in HD may trigger the death of cortical and striatal neurons through different molecular events...
  52. ncbi Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases
    Bodo Brueckner
    Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Res 65:6305-11. 2005
    ..These results establish RG108 as a DNA methyltransferase inhibitor with fundamentally novel characteristics that will be particularly useful for the experimental modulation of epigenetic gene regulation...
  53. ncbi Neuroprotection and neuronal dysfunction upon repetitive inhibition of oxidative phosphorylation
    R Hellweg
    Department of Psychiatry, Free University, Berlin, Germany
    Exp Neurol 183:346-54. 2003
    ....
  54. ncbi S18886, a selective TP receptor antagonist, inhibits development of atherosclerosis in rabbits
    Nathalie F Worth
    Centre for Research in Vascular Biology, School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Atherosclerosis 183:65-73. 2005
    ..To investigate the effect of S18886, a novel TP (thromboxane A2 and prostaglandin endoperoxide) receptor antagonist, on the development of aortic fatty streaks and advanced lesions in a rabbit model of atherosclerosis and restenosis...
  55. ncbi N-carbamylglutamate protects patients with decompensated propionic aciduria from hyperammonaemia
    B Gebhardt
    Department of General Paediatrics, Johann Wolfgang Goethe University of Frankfurt a M, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    J Inherit Metab Dis 28:241-4. 2005
    ..Safe, fast and easy to administer, carbamyl glutamate improves the acute therapy of decompensated propionic aciduria by increasing ammonia detoxification and avoiding hyperammonaemia...
  56. ncbi Methylcitrate synthase from Aspergillus nidulans: implications for propionate as an antifungal agent
    M Brock
    Laboratorium für Mikrobiologie, Fachbereich Biologie, Philipps Universitat, D 35032 Marburg, Germany
    Mol Microbiol 35:961-73. 2000
    ..Propionate (100 mM) not only impaired hyphal growth of A. nidulans but also synthesis of the green polyketide-derived pigment of the conidia, whereas in the mutant pigmentation was abolished with 20 mM propionate...
  57. ncbi Altered oxidative stress response of the long-lived Snell dwarf mouse
    Mark A Madsen
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0643, USA
    Biochem Biophys Res Commun 318:998-1005. 2004
    ..We propose that this altered management of oxidative stress in dwarf mice is partially responsible for the increased longevity in Snell dwarf mice...
  58. ncbi 3-mercaptopropionate dioxygenase, a cysteine dioxygenase homologue, catalyzes the initial step of 3-mercaptopropionate catabolism in the 3,3-thiodipropionic acid-degrading bacterium variovorax paradoxus
    Nadine Bruland
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, Corrensstrasse 3, Munster D 48149, Germany
    J Biol Chem 284:660-72. 2009
    ....
  59. pmc Delayed apoptosis of human monocytes exposed to immune complexes is reversed by oxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway
    Luciano Ottonello
    First Medical Clinic, Laboratory of Phagocyte Physiopathology and Inflammation, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Br J Pharmacol 157:294-306. 2009
    ..Their effects have been explained on the basis of cyclooxygenase (COX) inhibition. However, some of the actions of these drugs are not related to inhibition of prostaglandin synthesis...
  60. ncbi Treatment with bindarit, a blocker of MCP-1 synthesis, protects mice against acute pancreatitis
    Madhav Bhatia
    Dept of Pharmacology, National Univ of Singapore, Faculty of Medicine, Bldg MD2, 18 Medical Dr, Singapore 117597
    Am J Physiol Gastrointest Liver Physiol 288:G1259-65. 2005
    ....
  61. ncbi Impact of the anti-inflammatory agent bindarit on the chemokinome: selective inhibition of the monocyte chemotactic proteins
    Massimiliano Mirolo
    Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    Eur Cytokine Netw 19:119-22. 2008
    ..Here we report on the use of inhibition of synthesis as a potentially viable and selective approach to modify the chemokine system...
  62. ncbi A review of the emerging profile of the anti-inflammatory drug oxaprozin
    Franco Dallegri
    Dipartimento di Medicina Interna e Specialita Mediche, Universita degli Studi di Genova, Viale Benedetto XV, N 6, 16132 Genova, Italy
    Expert Opin Pharmacother 6:777-85. 2005
    ....
  63. ncbi Malonate and 3-nitropropionic acid neurotoxicity are reduced in transgenic mice expressing a caspase-1 dominant-negative mutant
    O A Andreassen
    Neurochemistry Laboratory, Neurology Service, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Neurochem 75:847-52. 2000
    ..These results provide further evidence of a functional role for caspase-1 in both malonate- and 3-NP-mediated neurotoxin models of HD...
  64. ncbi Oxaprozin versus diclofenac in NSAID-refractory periarthritis pain of the shoulder
    Barbara Heller
    Zenter für Klinische Studien, Frankfurt, Germany
    Curr Med Res Opin 20:1279-90. 2004
    ....
  65. ncbi Oxaprozin: kinetic and dynamic profile in the treatment of pain
    Walter F Kean
    Curr Med Res Opin 20:1275-7. 2004
    ..in several different painful musculoskeletal conditions...
  66. ncbi Calpain is a major cell death effector in selective striatal degeneration induced in vivo by 3-nitropropionate: implications for Huntington's disease
    Nicolas Bizat
    Unité de Recherche Associée Commissariat à l Energie Atomique CEA Centre National de la Recherche Scientifique, Service Hospitalier Frederic Joliot, Département de Recherche Médicale DRM, Direction des Sciences du Vivant DSV, CEA, Orsay, France
    J Neurosci 23:5020-30. 2003
    ..This suggests that calpain may play an important role in HD pathogenesis and could be a potential therapeutic target to slow disease progression...
  67. ncbi Brain mitochondrial defects amplify intracellular [Ca2+] rise and neurodegeneration but not Ca2+ entry during NMDA receptor activation
    Carine Jacquard
    Unité de Recherche Associée CEA CNRS 2210, Service Hospitalier Frederic Joliot, Département de Recherches Médicales, Direction des Sciences du Vivant, Commissariat a l Energie Atomique, 4 Place du General Leclerc, 91401 Orsay Cedex, France
    FASEB J 20:1021-3. 2006
    ..The present results demonstrate that the potentiation of NMDA-R-mediated excitotoxicity by mitochondrial defects involves primarily intracellular Ca2+ deregulation, in the absence of NMDA-R hypersensitivity...
  68. ncbi Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington's disease
    Soon Tae Lee
    Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Chongro Gu, Seoul, South Korea
    Brain Res 1118:199-207. 2006
    ..Subsequently, memantine was found to have neuroprotective effects and save striatal cells with decreasing calpain levels in the 3NP model of Huntington's disease...
  69. ncbi The effect of aging on p38 signaling pathway activity in the mouse liver and in response to ROS generated by 3-nitropropionic acid
    Ching Chyuan Hsieh
    Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch, 613 Basic Sci Bldg, Rt 0643, Galveston, TX 77555 0643, USA
    Mech Ageing Dev 123:1423-35. 2002
    ....
  70. ncbi The Prevention of cerebrovascular and cardiovascular Events of ischemic origin with teRutroban in patients with a history oF ischemic strOke or tRansient ischeMic attack (PERFORM) study: baseline characteristics of the population
    M G Bousser
    Department of Neurology, Hôpital Lariboisière AP HP, INSERM U 740, Paris, France
    Cerebrovasc Dis 27:608-13. 2009
    ..Here we describe the baseline characteristics of the population...
  71. ncbi Striatal and cortical neurochemical changes induced by chronic metabolic compromise in the 3-nitropropionic model of Huntington's disease
    David Blum
    Laboratoire de Neurophysiologie, ULB Erasme, CP601, 808 Route de Lennik, 1070 Brussels, Belgium
    Neurobiol Dis 10:410-26. 2002
    ....
  72. ncbi Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies
    Jae K Ryu
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    Neurobiol Dis 12:121-32. 2003
    ..The present results indicate that metabolic impairment in the CNS could involve both activation and cell death of microglia and contribute to pathology in neurodegenerative diseases...
  73. pmc Localization of superoxide anion production to mitochondrial electron transport chain in 3-NPA-treated cells
    Attila Bacsi
    Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA
    Mitochondrion 6:235-44. 2006
    ..These results indicate that in the presence of 3-NPA, mitochondria generate O2- from a site between the ubiquinol pool and the 3-NPA block in the respiratory complex II...
  74. ncbi Characterization of microbial polythioesters: physical properties of novel copolymers synthesized by Ralstonia eutropha
    Tina Lütke-Eversloh
    Institut fur Mikrobiologie, Westfalische Wilhelms Universitat Munster, Corrensstrasse 3, D 48149 Munster, Germany
    Biomacromolecules 3:159-66. 2002
    ..The copolyester poly(3HB-co-3MB) displayed very low crystallinity and melting points higher than that of poly(3HB) when the 3HB content was 40% or less...
  75. pmc Novel pathway for catabolism of the organic sulfur compound 3,3'-dithiodipropionic acid via 3-mercaptopropionic acid and 3-Sulfinopropionic acid to propionyl-coenzyme A by the aerobic bacterium Tetrathiobacter mimigardefordensis strain DPN7
    Jan Hendrik Wübbeler
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, 48149 Munster, Germany
    Appl Environ Microbiol 74:4028-35. 2008
    ..Therefore, a new pathway is proposed for the catabolism of DTDP via 3MP, 3SP, and 3SP-CoA toward propionyl-CoA, which is then further catabolized via the 2-methylcitric acid cycle in T. mimigardefordensis...
  76. ncbi Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence
    Ernesto J Muñoz-Elías
    Laboratory of Infection Biology, The Rockefeller University, New York, NY 10021, USA
    Mol Microbiol 60:1109-22. 2006
    ..Paradoxically, bacterial growth and persistence, and tissue pathology, were indistinguishable in mice infected with wild-type or DeltaprpDC bacteria...
  77. ncbi Amelioration of rat adjuvant arthritis by therapeutic treatment with bindarit, an inhibitor of MCP-1 and TNF-alpha production
    A Guglielmotti
    Immunopharmacology Lab, ACRAF SpA Angelini Ricerche, Rome, Italy
    Inflamm Res 51:252-8. 2002
    ..This study was designed to evaluate therapeutic effects of bindarit, an indazolic derivative able to inhibit monocyte chemoattractant protein-1 (MCP-1) production, in adjuvant induced arthritis in rats...
  78. ncbi In vivo brain phosphocreatine and ATP regulation in mice fed a creatine analog
    D Holtzman
    Department of Neurology, Children s Hospital, Boston, Massachusetts, USA
    Am J Physiol 272:C1567-77. 1997
    ..Thus GPA, GPAP, or adaptive changes in ATP metabolism stabilize brain ATP and enhance survival during hypoxia in mice...
  79. ncbi Novel precursor substrates for polythioesters (PTE) and limits of PTE biosynthesis in Ralstonia eutropha
    Tina Lütke-Eversloh
    Institut fur Mikrobiologie, Westfalische Wilhelms Universitat Munster, Germany
    FEMS Microbiol Lett 221:191-6. 2003
    ..Therefore, this study not only extended the range of substrates suitable for PTE biosynthesis and also the range of PTE constituents in R. eutropha, it also demonstrates limits for PTE biosynthesis in this bacterium...
  80. ncbi Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30 mg/day versus aspirin 100 mg/day in stroke patients: the prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with
    M G Bousser
    Hôpital Lariboisière AP HP, INSERM U 740, Paris, France
    Cerebrovasc Dis 27:509-18. 2009
    ....
  81. ncbi Atherosclerosis regression and TP receptor inhibition: effect of S18886 on plaque size and composition--a magnetic resonance imaging study
    Juan F Viles-Gonzalez
    Cardiovascular Biology Research Laboratory, Cardiovascular Institute, PO Box 1030, Mount Sinai School of Medicine, New York, NY 10029, USA
    Eur Heart J 26:1557-61. 2005
    ..Consequently, we sought to assess the effect of a novel TP receptor antagonist S18886, on atherosclerotic lesion progression and composition by serial non-invasive magnetic resonance imaging (MRI)...
  82. ncbi Involvement of nitric oxide in 3-nitropropionic acid-induced striatal toxicity in rats
    Shripad B Deshpande
    Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India
    Brain Res 1108:205-15. 2006
    ..Taken together, these results suggest that 3-NPA generates NO both directly as a donor and indirectly by enhancing NOS expression to produce toxic effects on astrocytes and neuronal toxicity...
  83. ncbi Enhancement of tumor oxygenation and radiation response by the allosteric effector of hemoglobin, RSR13
    G P Amorino
    Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Radiat Res 156:294-300. 2001
    ..Based upon these results and other previous studies, the mechanism of enhancement of the effect of radiation by RSR13 probably involves an increase in tumor oxygenation...
  84. ncbi Thyroid hormone analogs for treatment of hypercholesterolemia and heart failure: past, present and future prospects
    Eugene Morkin
    Sarver Heart Center, University of Arizona, 1501 N Campbell Avenue, LSN358, P O Box 245046, Tucson, AZ 85724 5046, USA
    J Mol Cell Cardiol 37:1137-46. 2004
    ..A number of potential mechanisms are reviewed, including serum protein binding, tissue disposition, receptor binding, and gene activation. Clinical trials for thyroid hormone analogs are in prospect...
  85. ncbi Mitochondrial toxins and neurodegenerative diseases
    Antonio Ayala
    Departamento de Bioquimica, Bromatologia, Toxicologia y Medicina Legal, Facultad de Farmacia University of Seville, Spain
    Front Biosci 12:986-1007. 2007
    ..The aim of this review is to describe the most important toxins affecting the mitochondrial function, which could be involved in the incidence of some of these diseases: MPTP, rotenone and 3-nitropropionic (3-NPA)...
  86. ncbi Influence of cytosolic and mitochondrial Ca2+, ATP, mitochondrial membrane potential, and calpain activity on the mechanism of neuron death induced by 3-nitropropionic acid
    Payman Nasr
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA
    Neurochem Int 43:89-99. 2003
    ....
  87. ncbi Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration
    Trent M Woodruff
    Promics Ltd, The University of Queensland, Brisbane, QLD 4072, Australia
    FASEB J 20:1407-17. 2006
    ....
  88. ncbi Neuroprotective effect of taurine in 3-nitropropionic acid-induced experimental animal model of Huntington's disease phenotype
    Mariane G Tadros
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
    Pharmacol Biochem Behav 82:574-82. 2005
    ..Taken together, one may conclude that taurine has neuroprotective role in the current HD paradigm due, at least partly, to its indirect antioxidant effect and GABA agonistic action...
  89. ncbi UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders
    Eva de Lago
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Eur Neuropsychopharmacol 16:7-18. 2006
    ....
  90. ncbi Neuroprotective effect of zVAD against the neurotoxin 3-nitropropionic acid involves inhibition of calpain
    Nicolas Bizat
    URA CEA CNRS 2210, Service Hospitalier Frédéric Joliot and Program ImaGene, DRM, DSV, CEA, 4 Place du General Leclerc, 91401 Orsay, France
    Neuropharmacology 49:695-702. 2005
    ..The present data demonstrate that zVAD protects neurons against 3NP through calpain inhibition. This suggests that, in certain models of neuronal death where zVAD showed protective effects, caspases but also calpains may be involved...
  91. ncbi Mice transgenic for the Huntington's disease mutation are resistant to chronic 3-nitropropionic acid-induced striatal toxicity
    M A Hickey
    Department of Pharmacology, University of Cambridge, Cambridge, England
    J Neurochem 75:2163-71. 2000
    ..The existence of similar compensatory mechanisms may explain why, in humans, HD is a late-onset disorder, despite early expression of the genetic mutation...
  92. ncbi 17 beta-Estradiol may affect vulnerability of striatum in a 3-nitropropionic acid-induced experimental model of Huntington's disease in ovariectomized rats
    Isaac Tunez
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Cordoba, Spain
    Neurochem Int 48:367-73. 2006
    ....
  93. ncbi Preservation of striatal tissue and behavioral function after neural stem cell transplantation in a rat model of Huntington's disease
    T J Roberts
    Neuroimaging Research Group P042, Department of Neurology, King s College London, Institute of Psychiatry, UK
    Neuroscience 139:1187-99. 2006
    ..Serial imaging therefore warrants further implementation in clinical trials of neural grafts to monitor in vivo changes in the damaged brain due to transplantation...
  94. ncbi Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease
    Isabel Lastres-Becker
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    J Neurochem 84:1097-109. 2003
    ....
  95. ncbi Exacerbation of excitotoxic neuronal death induced during mitochondrial inhibition in vivo: relation to energy imbalance or ATP depletion?
    P Del Rio
    Depto de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico, D F CP 04510, Mexico
    Neuroscience 146:1561-70. 2007
    ..Enhancement of glutamate neurotoxicity in 3-NP pre-treated rats is more related to a sustained nucleotide imbalance than just to a rapid decrease in ATP levels...
  96. ncbi Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms
    Puneet Kumar
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Punjab University, Chandigarh, India
    Behav Pharmacol 17:485-92. 2006
    ....
  97. ncbi Plastic and behavioral abnormalities in experimental Huntington's disease: a crucial role for cholinergic interneurons
    Barbara Picconi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 65, 00143 Rome, Italy
    Neurobiol Dis 22:143-52. 2006
    ....
  98. ncbi Effect of testosterone on oxidative stress and cell damage induced by 3-nitropropionic acid in striatum of ovariectomized rats
    Isaac Tunez
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Cordoba, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Life Sci 80:1221-7. 2007
    ..Additionally, these data support the hypothesis that testosterone might play an important role in the onset and development of neurodegenerative diseases...
  99. ncbi Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease
    Shilpa Ramaswamy
    Department of Neuroscience, Rush University Medical Center, 1735 West Harrison Street, Suite 300, Chicago, IL 60612, USA
    Neurobiol Dis 26:375-84. 2007
    ..Stereological counts revealed a significant protection of NeuN-ir striatal neurons from 3NP toxicity by AAV2-NTN. These data support the concept that AAV2-NTN might be a valuable treatment for patients with Huntington's disease...
  100. ncbi Transcranial magnetic stimulation attenuates cell loss and oxidative damage in the striatum induced in the 3-nitropropionic model of Huntington's disease
    Isaac Tunez
    Departamento de Bioquimica y Biologia Molecular, Y, Facultad de Medicina, Universidad de Cordoba, Cordoba, Spain
    J Neurochem 97:619-30. 2006
    ..In conclusion, the results show the ability of TMS to modify neuronal response to 3-nitropropionic acid...
  101. ncbi Possible neuroprotective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity
    P Kumar
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Methods Find Exp Clin Pharmacol 29:19-25. 2007
    ..The results of the present study clearly indicate that curcumin by its antioxidant activity showed neuroprotection against 3-NP-induced behavioral and biochemical alteration...

Research Grants63

  1. NGF Receptor Regulates Prostate Growth
    Daniel Djakiew; Fiscal Year: 2009
    ..either by ectopic re-expression, or by alternate novel mechanisms, such as by induction with select aryl propionic acids such as carprofen, ibuprofen and r-flurbiprofen, restores its growth inhibitory activity...
  2. INACTIVATION AND STRUCTURE AND GABA AMINOTRANSFERASE
    Richard Silverman; Fiscal Year: 1999
    ..GABA, (E)- and (Z)-4-amino-3-(fluoromethylene)butyric acids, (E)- and (Z)-3-amino-2- (fluoromethylene)propionic acids, cis- and trans-4-aminocyclopent-2-ene- 1-carboxylic acid, 3-aminocyclopent-ene-1-carboxylic acid, cis- and ..
  3. Chemosensitization of Pancreatic Tumors via Inhibition of a DNA BER Enzyme, Ape1
    Melissa Fishel; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  4. Development of NET-Selective Piperidine-Based PET Ligand
    Anna Liisa Brownell; Fiscal Year: 2006
    ..4. Promising PET imaging agents will be studied in cell toxicity and animal models during the second year. ..
  5. Imbalancing DNA BER to enhance Ovarian Tumor Sensitivity
    Mark Kelley; Fiscal Year: 2008
    ..abstract_text> ..
  6. Reconstruction of nigrostriatal pathway by photopolymerized neurotrophin...
    Kimberly Bjugstad; Fiscal Year: 2008
    ..While we are using an animal model of PD to test this hypothesis, if successful, it could have implications for other neurodegenerative disorders, including Huntington's Disease or stroke. [unreadable] [unreadable] [unreadable]..
  7. Combination Drug Therapy in Huntington's Disease
    ROBERT FERRANTE; Fiscal Year: 2008
    ..abstract_text> ..
  8. Therapeutic/Mechanistic Role of Ape1 in Germ Cell Tumors
    Mark Kelley; Fiscal Year: 2007
    ..If any mutants are shown to sensitize the GCT cell lines to chemo-/IR agents, as expected, this will set the stage for future gene therapy approaches to sensitize GCT's to therapy. ..
  9. Perinatal hypoxia-ischemia, glutamate receptors, and Nitric Oxide Synthase
    Zhengwei Cai; Fiscal Year: 2007
    ..Direct effects of inflammatory cytokines and IGF-1 on survival and differentiation of OLs will be examined in cultures of OLs at various maturation stages. ..
  10. Dynamic Metabolomics via Isotopomer Analysis
    Henri Brunengraber; Fiscal Year: 2006
    ..Second, we provide a rigorous test of the hypothesis that the mathematical analysis of mass isotopomer data enhances concentration-based metabolomics to provide new avenues for understanding metabolic diseases. ..
  11. F-18 Synthesizer
    Anna Liisa Brownell; Fiscal Year: 2007
    ..The synthesizer must balance a number of factors in the design to fulfill requirements for performance, accessibility and fitness to the research environment. [unreadable] [unreadable] [unreadable]..
  12. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2007
    ..In addition, transgenic mice lacking PACAP and VIP will be analyzed with behavioral and anatomical tools. These newly developed mice are likely to prove a useful tool for circadian rhythms research. ..
  13. Novel Single, Dual and Multitargeted Inhibitors of RTKs
    Aleem Gangjee; Fiscal Year: 2007
    ..abstract_text> ..
  14. Bioenergetics in Animal Models of Huntington's Disease
    M Beal; Fiscal Year: 2007
    ..We will, therefore, examine whether a combination of creatine or coenzyme Q with either a HDAC inhibitor or a phosphodiesterase IV inhibitor can exert additive neuroprotective effects. [unreadable] [unreadable]..
  15. Perinatal infection, cytokines and brain injury
    Zhengwei Cai; Fiscal Year: 2008
    ....
  16. Olfaction as a Biomarker for Parkinson's Disease
    Anna Liisa Brownell; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. Interactions for Pesticides, mitochondria and genetics in Parkinson's disease.
    M Flint Beal; Fiscal Year: 2010
    ..The study will enrich and refine our understanding of pesticide-induced cell damage pathways observed in sporadic and familial PD and identify new target(s) for intervention in PD pathogenesis. ..
  18. Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor Agents
    Aleem Gangjee; Fiscal Year: 2010
    ....
  19. Reflexes and Supraesophageal Consequences of Reflux Disease
    Brendan J Canning; Fiscal Year: 2010
    ..This research may also help identify novel therapeutic strategies for treating both GERD and chronic cough. ..
  20. MOLECULAR BASIS OF COAGULATION PROTEASE SPECIFICITY
    Alireza R Rezaie; Fiscal Year: 2010
    ....
  21. Single Agents with Designed Combination Chemotherapy Potential
    Aleem Gangjee; Fiscal Year: 2010
    ..abstract_text> ..
  22. Antitumor Antimitotics That Reverse Tumor Resistance
    Aleem Gangjee; Fiscal Year: 2010
    ..The study will also further define the mechanism of action of the novel series and could afford agents for clinical use. ..
  23. The Role of the KLF2 in Vascular Endothelial Cells
    Jerry B Lingrel; Fiscal Year: 2010
    ..Importantly, they will serve as a prerequisite for further investigation of KLF2 as a vaso-protective therapeutic target. ..
  24. Metabolomic and Isotopomer Analysis of Xenobiotic Stress
    Henri Brunengraber; Fiscal Year: 2009
    ..This will be achieved by administering low doses of 2H20 and acetaminophen, followed by measuring the 2H-labeling of urinary acetaminophen-glutathione adduct. ..
  25. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2009
    ..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
  26. Nutritional Treatment of Fat Oxidation Defect in Mice
    Henri Brunengraber; Fiscal Year: 2009
    ..To improve the survival of newborn MTP -/- mice. ..
  27. Development of New Therapies for Huntington's Disease
    M Beal; Fiscal Year: 2008
    ..We believe that these studies will provide critical pre-clinical data to determine the agents, which have the most promise for use as neuroprotective agents in clinical drug trials in HD patients. ..
  28. Novel Approaches for in vivo of mGluRs
    Anna Liisa Brownell; Fiscal Year: 2006
    ..abstract_text> ..
  29. Retinal Inputs to the Mammalian Circadian Pacemaker
    KWOON WONG; Fiscal Year: 2006
    ..These experiments may enable a better understanding of how the mammalian circadian pacemaker is regulated, which in turn may lead to better therapies and workplace policies combating/preventing jet lag problems. ..
  30. INVESTIGATIONS ON GLUCONEOGENESIS
    Henri Brunengraber; Fiscal Year: 2003
    ..We hope that the data of our investigations will help to devise new strategies for improving the treatment of type I diabetic patients. ..
  31. GC Continuous Flow Isotope Ratio Mass Spectrometer
    Henri Brunengraber; Fiscal Year: 2003
    ..The costs of operating and maintaining the instrument will be shared by the users. The availability of this instrument will considerably increase the scope of the basic science and clinical investigations conducted by the applicants. ..
  32. REGULATION OF THE MAMMALIAN CIRCADIAN SYSTEM
    Christopher Colwell; Fiscal Year: 2002
    ..Finally, the proposed work will determine whether a model developed to explain synchronization of molluscan circadian oscillators can be applied to the mammalian SCN. ..
  33. OLFACTORY CODING
    Burton Slotnick; Fiscal Year: 2003
    ..Behavior tasks will use precision olfactometry. Anterograde transport of horseradish peroxidase will be used to assess connections between the olfactory epithelium and olfactory bulb in experimental rats. ..
  34. BENCH TO CLINIC IN CONCURRENT CHEMORADIATION THERAPY
    Hak Choy; Fiscal Year: 2003
    ..abstract_text> ..
  35. NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORS
    Aleem Gangjee; Fiscal Year: 2004
    ....
  36. Guided Pocket Recolonization (GPR) in Periodontitis
    Marc Quirynen; Fiscal Year: 2004
    ..Clinical data will be collected after 2, 4, 6, 8 and 12 weeks. The results should indicate the possible role for commensal organisms in periodontal disease and subgingival biofilm formation. ..
  37. DYSGENIC KIDNEY LETHAL MUTANT MICE
    Jerry Lingrel; Fiscal Year: 2003
    ..These studies will lead to an understanding of how the functions of new genes affect kidney development and provide an insight into the process of nephrogenesis. ..
  38. PH REGULATION IN VENTRICULAR CELLS
    KENNETH SPITZER; Fiscal Year: 2002
    ..The results of this project will yield new information concerning hormonal modulation of cardiac pHi control systems and the action of intracellular and intercellular H+ diffusion to dissipate regional pHi gradients. ..
  39. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
    ..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
  40. STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTS
    Aleem Gangjee; Fiscal Year: 2001
    ..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..
  41. Interactions of Black Cohosh with Cancer Therapy
    Sara Rockwell; Fiscal Year: 2005
    ..This project will assess these possibilities. The findings will show whether this herb is inactive and harmless, potentially dangerous to breast cancer patients, or of potential value in the treatment of this disease. ..
  42. AUTONOMIC REGULATION OF AIRWAY SMOOTH MUSCLE TONE
    BRENDAN CANNING; Fiscal Year: 2001
    ..It is anticipated that this information will improve our understanding of the role of the autonomic innervation of the healthy and diseased lung. ..
  43. Antioxidant Approaches to Alzheimer's Disease Therapy
    M Beal; Fiscal Year: 2007
    ..If we can demonstrate significant effects of CoQ10 and L-NIL, this could lead to rapid development of new therapies for slowing the progression of AD. [unreadable] [unreadable]..
  44. METHAMPHETAMINE AND HIV PROTEIN-INDUCED NEUROTOXICITY
    William Maragos; Fiscal Year: 2005
    ..To accomplish these goals, we will assess the effects of intrastriatal injections of virotoxins in animals treated with methamphetamine and in vitro in human cortical neurons where cell types can be manipulated. ..
  45. Studies of the Lung Kruppel-Like Transcription Factor
    Jerry Lingrel; Fiscal Year: 2004
    ..We will use gene microarray analysis of cells with and without the LKLF gene and develop conditional expression of LKLF to define downstream target genes in tissues such as lung, macrophages and T-lymphocytes. ..
  46. OXIDATIVE INJURY IN PARKINSONS DISEASE
    ROBERT FERRANTE; Fiscal Year: 2002
    ..These studies will have direct relevance to understanding the pathogenesis of PD and to developing new therapies. ..
  47. OLFACTORY FUNCTION IN GENE-TARGETED MICE
    Burton Slotnick; Fiscal Year: 2002
    ..A final report of these studies will incorporate a detailed description of apparatus, methods protocol and files of raw data and summary statistics presented in database and spreadsheet format. ..
  48. FUNCTIONAL STUDIES OF THE NA,K-ATPASE
    Jerry Lingrel; Fiscal Year: 2009
    ..These matings will provide animals where the alpha2 isoform is missing only in heart or smooth muscle and this will allow us to study the specific role of this isoform in cardiovascular function. ..
  49. Propeptide-Mediated Protein Folding
    Masayori Inouye; Fiscal Year: 2006
    ..Another emphasis is to investigate how the nascent folding intermediate can be activated with small peptide substrates. ..
  50. MICROPET FOR ANIMAL STUDIES
    Anna Liisa Brownell; Fiscal Year: 2001
    ..Our previous experience in developing and operating PET systems will be of great benefit in the expansion of the facility. ..
  51. KININS AS MEDIATORS OF HUMAN REACTIONS
    BRENDAN CANNING; Fiscal Year: 2003
    ..These rigorous studies will not only clarify the role of BK in airway diseases, but will also have broader relevance by providing new and important insights into how neural function is altered in asthma and rhinitis. ..
  52. Dopamine Toxicity in Models of Huntington's Disease
    William Maragos; Fiscal Year: 2004
    ..The results of these studies will demonstrate the critical role that metabolism of dopamine plays in striatal neuron death in Huntington's disease and offer a potentially novel therapeutic approach for the treatment of this disorder. ..
  53. Apoptotic and Necrotic Death of OHCs in NIHL
    Bo Hua Hu; Fiscal Year: 2006
    ..The knowledge of the biological mechanisms responsible for modulation of the cell death pathways will provide the basis for eventually developing a rational protective strategy. ..
  54. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    JANICE WAGNER; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  55. The molecular bases of inherited urea cycle disorders and ureagenesis regulation
    Mendel Tuchman; Fiscal Year: 2010
    ....
  56. Experience-Dependent Plasticity of Neocortical Inhibitory Networks
    QIANQUAN SUN; Fiscal Year: 2010
    ..This information could have implications for developing novel treatment strategies for developmental neurological and psychiatric disorders that result from aberrant connectivity among neocortical principal neurons and interneurons. ..
  57. Training Program in Molecular and Cellular Toxicology
    John Reiners; Fiscal Year: 2008
    ..It is envisioned that students with such training will be better equipped to pursue postdoctoral research at major research laboratories throughout the United States. ..
  58. REVERSE TRANSCRIPTASES IN THE PROKARYOTES
    Masayori Inouye; Fiscal Year: 2004
    ....
  59. Cold Shock Vectors for Single Protein Production
    Masayori Inouye; Fiscal Year: 2004
    ..The proposed vector-host system will be highly useful not only for structural biology but also for medicinal research involving human proteins, which can not be obtained by conventional expression systems. ..
  60. Signal Transduction by Histidine Kinases and their Response Regulators
    Masayori Inouye; Fiscal Year: 2009
    ..abstract_text> ..
  61. STRESS RESPONSE AND ADAPTATION IN ESCHERICHIA COLI
    Masayori Inouye; Fiscal Year: 2003
    ..The proposed research will provide important insight into the fundamental principles of stress response and adaptation in prokaryotes. ..