succinates

Summary

Summary: The salts and esters of SUCCINIC ACID and its derivatives.

Top Publications

  1. ncbi Cross-reactivity documented for hemaccel and gelofusin
    W John Russell
    Anesth Analg 98:1499; author reply 1500. 2004
  2. ncbi Biotechnological production of itaconic acid and its biosynthesis in Aspergillus terreus
    Mitsuyasu Okabe
    Musashino Chemical Laboratory, Ltd, Yaesu Daibiru Bldg, 1 1 1 Kyobashi, Chuo Ku, Tokyo, 104 0031, Japan
    Appl Microbiol Biotechnol 84:597-606. 2009
  3. ncbi High prevalence of natural polymorphisms in Gag (CA-SP1) associated with reduced response to Bevirimat, an HIV-1 maturation inhibitor
    Eduardo Seclen
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    AIDS 24:467-9. 2010
  4. ncbi Biotechnological production of itaconic acid
    T Willke
    Federal Agricultural Research Centre, Institute of Technology and Biosystems Engineering, Braunschweig, Germany
    Appl Microbiol Biotechnol 56:289-95. 2001
  5. doi A clone-based transcriptomics approach for the identification of genes relevant for itaconic acid production in Aspergillus
    An Li
    TNO Microbiology and Systems Biology, PO Box 360, 3700 AJ Zeist, Netherlands
    Fungal Genet Biol 48:602-11. 2011
  6. ncbi Intracellular expression of Vitreoscilla hemoglobin in Aspergillus terreus to alleviate the effect of a short break in aeration during culture
    Yu Hui Lin
    Institute of Biochemistry, University System of Taiwan National Yang Ming University, Shih Pai, Taipei 112, Taiwan, R O C
    Biotechnol Lett 26:1067-72. 2004
  7. pmc The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles
    Albert T Nguyen
    Department of Microbiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Retrovirology 8:101. 2011
  8. doi Cloning and functional characterization of the cis-aconitic acid decarboxylase (CAD) gene from Aspergillus terreus
    Shin Kanamasa
    JST Innovation Satellite Shizuoka, Japan Science and Technology Agency, 3 5 1 Johoku, Naka ku, Hamamatsu, 432 8561, Japan
    Appl Microbiol Biotechnol 80:223-9. 2008
  9. doi Succination of proteins in diabetes
    Norma Frizzell
    Department of Exercise Science, School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Free Radic Res 45:101-9. 2011
  10. pmc In vitro selection of clinically relevant bevirimat resistance mutations revealed by "deep" sequencing of serially passaged, quasispecies-containing recombinant HIV-1
    David J H F Knapp
    BC Centre for Excellence in HIV AIDS, 603 1081 Burrard St, Vancouver, BC, Canada
    J Clin Microbiol 49:201-8. 2011

Detail Information

Publications195 found, 100 shown here

  1. ncbi Cross-reactivity documented for hemaccel and gelofusin
    W John Russell
    Anesth Analg 98:1499; author reply 1500. 2004
  2. ncbi Biotechnological production of itaconic acid and its biosynthesis in Aspergillus terreus
    Mitsuyasu Okabe
    Musashino Chemical Laboratory, Ltd, Yaesu Daibiru Bldg, 1 1 1 Kyobashi, Chuo Ku, Tokyo, 104 0031, Japan
    Appl Microbiol Biotechnol 84:597-606. 2009
    ....
  3. ncbi High prevalence of natural polymorphisms in Gag (CA-SP1) associated with reduced response to Bevirimat, an HIV-1 maturation inhibitor
    Eduardo Seclen
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    AIDS 24:467-9. 2010
    ..Conversely, only four patients (1%) harbored major bevirimat resistance mutations. Finally, specific gag changes were associated with protease inhibitor resistance mutations in subtype B viruses...
  4. ncbi Biotechnological production of itaconic acid
    T Willke
    Federal Agricultural Research Centre, Institute of Technology and Biosystems Engineering, Braunschweig, Germany
    Appl Microbiol Biotechnol 56:289-95. 2001
    ..Also, the use of alternative substrates may reduce costs and thus open the market for new and increased applications...
  5. doi A clone-based transcriptomics approach for the identification of genes relevant for itaconic acid production in Aspergillus
    An Li
    TNO Microbiology and Systems Biology, PO Box 360, 3700 AJ Zeist, Netherlands
    Fungal Genet Biol 48:602-11. 2011
    ..Interestingly, this cluster is directly linked to the large lovastatin gene cluster...
  6. ncbi Intracellular expression of Vitreoscilla hemoglobin in Aspergillus terreus to alleviate the effect of a short break in aeration during culture
    Yu Hui Lin
    Institute of Biochemistry, University System of Taiwan National Yang Ming University, Shih Pai, Taipei 112, Taiwan, R O C
    Biotechnol Lett 26:1067-72. 2004
    ..During itaconic acid production, the effect of a break in aeration during cultivation in the transformant with the vgb gene is alleviated. Additionally, the transformant shows improved itaconic acid production...
  7. pmc The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles
    Albert T Nguyen
    Department of Microbiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Retrovirology 8:101. 2011
    ..In contrast to inhibitors that target the active site of the viral protease, bevirimat specifically inhibits a single cleavage event, the final processing step for the Gag precursor where p25 (CA-SP1) is cleaved to p24 (CA) and SP1...
  8. doi Cloning and functional characterization of the cis-aconitic acid decarboxylase (CAD) gene from Aspergillus terreus
    Shin Kanamasa
    JST Innovation Satellite Shizuoka, Japan Science and Technology Agency, 3 5 1 Johoku, Naka ku, Hamamatsu, 432 8561, Japan
    Appl Microbiol Biotechnol 80:223-9. 2008
    ..This result reveals for the first time that this gene encodes CAD, which is essential for itaconic acid production in A. terreus...
  9. doi Succination of proteins in diabetes
    Norma Frizzell
    Department of Exercise Science, School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Free Radic Res 45:101-9. 2011
    ..2SC serves as a biomarker of mitochondrial stress and recent studies suggest that succination is the mechanistic link between mitochondrial and ER stress in diabetes...
  10. pmc In vitro selection of clinically relevant bevirimat resistance mutations revealed by "deep" sequencing of serially passaged, quasispecies-containing recombinant HIV-1
    David J H F Knapp
    BC Centre for Excellence in HIV AIDS, 603 1081 Burrard St, Vancouver, BC, Canada
    J Clin Microbiol 49:201-8. 2011
    ....
  11. pmc Susceptibility of human immunodeficiency virus type 1 to the maturation inhibitor bevirimat is modulated by baseline polymorphisms in Gag spacer peptide 1
    Kurt Van Baelen
    Virco BVBA, Generaal De Wittelaan L11 B3, 2800 Mechelen, Belgium
    Antimicrob Agents Chemother 53:2185-8. 2009
    ..We found that reduced BVM susceptibility was associated with naturally occurring polymorphisms at positions 6, 7, and 8 in Gag spacer peptide 1...
  12. ncbi Itaconic acid production using sago starch hydrolysate by Aspergillus terreus TN484-M1
    Lies Dwiarti
    Science of Biological Resources, The United Graduate School of Agricultural Science, Gifu University, 1 1 Yanagido, Gifu, Japan
    Bioresour Technol 98:3329-37. 2007
    ..This was filtered from the cultured broth and 37.1g of itaconic acid was recovered with a purity of 97.2%. This result showed that sago starch could be converted to a value-added product with only a simple pretreatment...
  13. ncbi Enhanced production of itaconic acid from corn starch and market refuse fruits by genetically manipulated Aspergillus terreus SKR10
    C S K Reddy
    Department of Biosciences and Biotechnology, Indian Institute of Technology, Roorkee
    Bioresour Technol 85:69-71. 2002
    ..Two high itaconic acid yielding mutants, N45 and UNCS1 were obtained by gradient plating. These two mutants were capable of producing twice the yield of itaconic acid as the parent strain...
  14. pmc Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1 maturation inhibitor bevirimat
    Catherine S Adamson
    Virus Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702 1201, USA
    Retrovirology 7:36. 2010
    ..Recent clinical trials demonstrated that a significant proportion of HIV-1-infected patients do not respond to BVM. A patient's failure to respond correlated with baseline polymorphisms at SP1 residues 6-8...
  15. pmc In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (Bevirimat)
    Catherine S Adamson
    Virus Cell Interaction Section, HIV Drug Resistance Program, NCI Frederick, Bldg 535 Rm 108, 1050 Boyles Street, Frederick, MD 21702 1201, USA
    J Virol 80:10957-71. 2006
    ..These findings have implications for the ongoing development of PA-457 to treat HIV-1 infection in vivo...
  16. pmc Phenotypic susceptibility to bevirimat in isolates from HIV-1-infected patients without prior exposure to bevirimat
    Nicolas A Margot
    Gilead Sciences, Inc, Foster City, CA 94404, USA
    Antimicrob Agents Chemother 54:2345-53. 2010
    ..Our results should be helpful in the design of diagnostics for prediction of the potential benefit of BVM treatment in HIV-1-infected patients...
  17. pmc Succination of proteins by fumarate: mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in diabetes
    Matthew Blatnik
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, USA
    Ann N Y Acad Sci 1126:272-5. 2008
    ....
  18. doi High prevalence of bevirimat resistance mutations in protease inhibitor-resistant HIV isolates
    Jens Verheyen
    Institute of Virology, University of Cologne, Cologne, Germany
    AIDS 24:669-73. 2010
    ..Bevirimat is the first drug of a new class of antivirals that hamper the maturation of HIV. The objective of this study was to evaluate the sequence variability of the gag region targeted by bevirimat in HIV subtype-B isolates...
  19. pmc Impact of human immunodeficiency virus type 1 resistance to protease inhibitors on evolution of resistance to the maturation inhibitor bevirimat (PA-457)
    Catherine S Adamson
    Virus Cell Interaction Section, HIV Drug Resistance Program, NCI Frederick, Frederick, MD 21702 1201, USA
    J Virol 83:4884-94. 2009
    ..These findings offer insights into the effect of PIR mutations on the evolution of BVM resistance in PI-experienced patients...
  20. pmc HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice
    Paul W Keller
    Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Building 50, Room 1517, 50 South Drive, MSC 8025, Bethesda, MD 20892, USA
    J Virol 85:1420-8. 2011
    ..In both cases, the observed failure to assemble mature capsids correlates with the loss of infectivity...
  21. pmc PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing
    F Li
    Panacos Pharmaceuticals Inc, 209 Perry Parkway, Gaithersburg, MD 20877, USA
    Proc Natl Acad Sci U S A 100:13555-60. 2003
    ..PA-457 represents a unique class of anti-HIV compounds termed maturation inhibitors that exploit a previously unidentified viral target, providing additional opportunities for HIV drug discovery...
  22. ncbi Promising phase I results against new HIV target
    Jo Whelan
    Drug Discov Today 9:823. 2004
  23. pmc 3-O-(3',3'-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 Gag precursor assembled in vitro
    Michael Sakalian
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Virol 80:5716-22. 2006
    ..With the establishment of an in vitro assay for the detection of PA-457 activity, a more detailed characterization of its mechanism of action will be possible...
  24. ncbi Identification of a gene cluster that directs putrebactin biosynthesis in Shewanella species: PubC catalyzes cyclodimerization of N-hydroxy-N-succinylputrescine
    Nadia Kadi
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    J Am Chem Soc 130:10458-9. 2008
    ....
  25. pmc HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat
    Axel Fun
    Department of Virology, Medical Microbiology, University Medical Center Utrecht, The Netherlands
    Retrovirology 8:70. 2011
    ..We used wild-type and protease inhibitor resistant viruses to determine the impact of protease inhibitor resistance mutations on the development of maturation inhibitor resistance...
  26. ncbi The 3-O-(3',3'-dimethylsuccinyl) derivative of betulinic acid (DSB) inhibits the assembly of virus-like particles in HIV-1 Gag precursor-expressing cells
    Sandrina DaFonseca
    Laboratoire de Virologie et Pathologie Humaine, Université de Lyon I and CNRS FRE 3011, Faculte de Medecine Laennec, 69372 Lyon 08, France
    Antivir Ther 12:1185-203. 2007
    ..The 3-O-(3',3'-dimethylsuccinyl) derivative of betulinic acid (DSB) blocks HIV-1 maturation by interfering with viral protease (PR) at the capsid (CA)-SP1 cleavage site, a crucial region in HIV-1 morphogenesis...
  27. ncbi Multiple-dose pharmacokinetics and safety of bevirimat, a novel inhibitor of HIV maturation, in healthy volunteers
    David E Martin
    Drug Development, Panacos Pharmaceuticals Inc, Gaithersburg, Maryland 20877, USA
    Clin Pharmacokinet 46:589-98. 2007
    ..Bevirimat [3-O-(3',3'-dimethylsuccinyl)-betulinic acid] is a novel inhibitor of HIV-1 maturation. This study was performed to investigate the pharmacokinetics and safety of bevirimat during repeated dosing in healthy volunteers...
  28. ncbi Determinants of activity of the HIV-1 maturation inhibitor PA-457
    Feng Li
    Panacos Pharmaceuticals, 209 Perry Parkway, Gaithersburg, MD 20877, USA
    Virology 356:217-24. 2006
    ..These findings support and extend previous observations that PA-457 is a specific inhibitor of CA-SP1 cleavage and identify the CA-SP1 domain as the primary viral determinant for this novel inhibitor of HIV-1 replication...
  29. ncbi Sarpogrelate HCl, a selective 5-HT2A antagonist, retards the progression of atherosclerosis through a novel mechanism
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Japan
    Atherosclerosis 168:23-31. 2003
    ....
  30. pmc Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag
    Jing Zhou
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, A 5301 Medical Center North, Nashville, TN 37232 2363, USA
    J Virol 80:12095-101. 2006
    ..These results have implications for the design of and screening for novel inhibitors of HIV-1 maturation...
  31. ncbi The role of 5-HT on the cardiovascular and renal systems and the clinical potential of 5-HT modulation
    Sheila A Doggrell
    School of Biomedical Sciences, University of Queensland, QLD 4072, Australia
    Expert Opin Investig Drugs 12:805-23. 2003
    ..In hypertension, agonists at the 5-HT(7) and antagonists at the 5-HT(2B) may reduce blood pressure, and in diabetes, sarpogrelate may protect against nephropathy...
  32. pmc The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acid
    Jing Zhou
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Retrovirology 1:15. 2004
    ....
  33. ncbi Maturation inhibitors: a new therapeutic class targets the virus structure
    Karl Salzwedel
    Panacos Pharmaceuticals, Inc, Gaithersburg MD, USA
    AIDS Rev 9:162-72. 2007
    ..These encouraging results, coupled with the discovery and development of future generations of maturation inhibitors, suggest that maturation inhibitors may be added to the growing set of tools available to control HIV/AIDS...
  34. pmc Safety and pharmacokinetics of Bevirimat (PA-457), a novel inhibitor of human immunodeficiency virus maturation, in healthy volunteers
    David E Martin
    Drug Development, Panacos Pharmaceuticals, 209 Perry Parkway, Suite 7, Gaithersburg, MD 20877, USA
    Antimicrob Agents Chemother 51:3063-6. 2007
    ..These findings suggest that that BVM offers a favorable pharmacokinetic profile, with predictable pharmacokinetics following the oral administration of single doses. The long half-life of BVM may facilitate once-daily dosing...
  35. pmc Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection
    Patrick F Smith
    Hoffman La Roche Inc, Clinical Pharmacology, Nutley, NJ 07110 1199, USA
    Antimicrob Agents Chemother 51:3574-81. 2007
    ..45 log(10), with individual patients having reductions of greater than 0.7 log(10). No bevirimat resistance mutations were detected during the course of the study...
  36. ncbi Sarpogrelate hydrochloride, a serotonin2A receptor antagonist, reduces albuminuria in diabetic patients with early-stage diabetic nephropathy
    Takeshi Takahashi
    Department of Internal Medicine, Kumamoto National Hospital Diabetes Center, 1 5 Ninomaru, Kumamoto City, Kumamoto 860 0008, Japan
    Diabetes Res Clin Pract 58:123-9. 2002
    ..Our study indicate that high levels of 5-HT in type 2 diabetics may be one of the underlying mechanisms of diabetic nephropathy, and that treatment with 5-HT(A2) receptor antagonists may reduce or inhibit the development of nephropathy...
  37. pmc Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice
    Cheryl A Stoddart
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e1251. 2007
    ..Bevirimat has a novel mechanism of action, specifically inhibiting cleavage of spacer peptide 1 (SP1) from the C-terminus of capsid which results in defective core condensation...
  38. ncbi Structural characterization of anti-HIV drug candidate PA-457 [3-O-(3',3'-dimethylsuccinyl)-betulinic acid] and its acyl glucuronides in rat bile and evaluation of in vitro stability in human and animal liver microsomes and plasma
    Zhiming Wen
    School of Pharmacy, CB 7360, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7360, USA
    Drug Metab Dispos 34:1436-42. 2006
    ..Minor putative acyl migration products were slowly formed at pH 9, suggesting that the acyl glucuronides of PA-457 have relatively high in vitro stability...
  39. ncbi Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection
    David E Martin
    Panacos Pharmaceuticals, Inc, Gaithersburg, MD, USA
    Antivir Chem Chemother 19:107-13. 2008
    ..Further studies to evaluate the long-term efficacy and tolerability of bevirimat are currently underway...
  40. ncbi Primary genotypic resistance of HIV-1 to the maturation inhibitor PA-457 in protease inhibitor-experienced patients
    Isabelle Malet
    Laboratoire de Virologie, Universite Pierre et Marie Curie Paris 6, France
    AIDS 21:871-3. 2007
    ..Overall, the CA-SP1 cleavage site was highly conserved in PI pre-treated patients and only one patient showed an L231M mutation. The impact of this mutation should be further addressed in vivo...
  41. ncbi Sarpogrelate treatment reduces restenosis after coronary stenting
    Masatoshi Fujita
    College of Medical Technology, Kyoto University, Kyoto, Japan
    Am Heart J 145:E16. 2003
    ..The aim of this study was to investigate whether sarpogrelate reduces restenosis after coronary stenting as a result of prevention of intimal hyperplasia...
  42. ncbi Effect of isoflurane on skin-pressure-induced vasodilation
    Lionel Fizanne
    UPRES EA 2170, Department of Medicine, Angers, France
    J Vasc Res 40:416-22. 2003
    ..It is not the anesthesia-induced hypotension, but the depth of anesthesia, which can lead to the disappearance of pressure-induced vasodilation by an alteration in endothelial function...
  43. pmc The isolated blood-perfused rat heart: an inappropriate model for the study of ischaemia- and infarction-related ventricular fibrillation
    Hugh Clements-Jewery
    Centre for Cardiovascular Biology and Medicine, King s College London, The Rayne Institute, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH
    Br J Pharmacol 137:1089-99. 2002
    ..This is because the similar neutrophil accumulation in ischaemic and sham hearts, the decline in numbers of circulating blood components, and the unexpected paucity of early VF all question the validity of the model...
  44. ncbi Preparative separation of cichoric acid from Echinacea purpurea by pH-zone-refining counter-current chromatography
    Xiao Wang
    Shandong Analysis and Test Center, Shandong Academy of Sciences, 19 Keyuan Street, Jinan, Shandong 250014, China
    J Chromatogr A 1103:166-9. 2006
    ..Double separations were performed with the same solvent system yielding 563 mg cichoric acid at 95.6% purity...
  45. ncbi The effect of replacement fluids and normovolaemic haemodilution on the survival of dorsal skin flaps in rats
    M Tuz
    Departmentsof ENT Head and Neck Surgery, School of Medicine, Suleyman Demirel University, Turkey
    Clin Otolaryngol Allied Sci 29:80-3. 2004
    ..If the blood loss exceeds 30% of total volume and/or haemoglobin (Hb) level is lower than 10.72 g/dL, the risk of flap necrosis increases significantly...
  46. ncbi [Effect of sarpogrelate in enteral feeding of patients with gastroesophageal reflux (GER)]
    Yukie Satou
    Department of Neurology, Hematology and Rheumatology, Shimane University Hospital
    Nihon Ronen Igakkai Zasshi 43:492-7. 2006
    ..Their most common serious complication is aspiration pneumonia. Our objectives were to evaluate the effect of sarpogrelate (a 5-HT2A receptor blocker) on gastroesophageal reflux (GER) in these patients...
  47. ncbi Contribution of the peripheral 5-HT 2A receptor to mechanical hyperalgesia in a rat model of neuropathic pain
    Aya Nitanda
    Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729 0292, Japan
    Neurochem Int 47:394-400. 2005
    ..Methysergide may act as a neutral antagonist that blocks the effect of inverse agonists on the 5-HT 2A receptor...
  48. ncbi 5-HT2A receptor subtype in the peripheral branch of sensory fibers is involved in the potentiation of inflammatory pain in rats
    Keiichiro Okamoto
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8509, Japan
    Pain 99:133-43. 2002
    ..These findings suggest that 5-HT2A receptors are mainly expressed in CGRP-synthesizing small DRG neurons and may be involved in the potentiation of inflammatory pain in the periphery...
  49. doi Blockade of serotonin 2A receptor improves glomerular endothelial function in rats with streptozotocin-induced diabetic nephropathy
    Shinya Kobayashi
    Division of Nephrology, Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701 0192, Japan
    Clin Exp Nephrol 12:119-25. 2008
    ..The aim of this study was to examine the effects of sarpogrelate on endothelial dysfunction in rats with streptozotocin (STZ)-induced diabetes...
  50. ncbi Effects of a 5-HT2A receptor antagonist, sarpogrelate on thermal or inflammatory pain
    Tomoki Nishiyama
    Department of Anesthesiology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur J Pharmacol 516:18-22. 2005
    ..In conclusion, sarpogrelate might be analgesic on inflammatory induced acute and facilitated pain by intrathecal or systemic administration. However, only systemic administration could be effective on thermal induced acute pain...
  51. ncbi Synthesis and 5-HT2A, 5-HT1A and alpha1-binding affinities of 2-[2-Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-hydroxy-3-(2-pyridin-2-yl-ethyl)amino]- and 2-[2-hydroxy-3-(4-N-methyl-piperazin-1-yl)-amino]propoxybenzaldehyde-O-(substituted) benzyl oximes
    Elisabetta Orlandini
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Pisa, Italy
    Arch Pharm (Weinheim) 340:135-9. 2007
    ..The results show that the compounds possess, at least partially, the ability of the model compounds 1 and 2 to interact with the 5-HT2A-receptors; they have the same selectivity towards 5-HT2A receptors vs alpha1-adrenoceptors...
  52. ncbi Sarpogrelate diminishes changes in energy stores and ultrastructure of the ischemic-reperfused rat heart
    R M Temsah
    Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 79:761-7. 2001
    ..05). This study provides evidence for the attenuation of IR-induced cardiac injury by 5-HT2A receptor blockade and supports the view that serotonin may contribute to the deleterious effects of IR in the heart...
  53. ncbi Effect of MCI-9042, a 5-HT2 receptor antagonist, on retinal ganglion cell death and retinal ischemia
    Eri Inoue-Matsuhisa
    Research Division, EI Research Institute Co, Ltd, c o Osaka Kasei Corporation, 2 6 11 Nakajima, Nishiyodogawaku, Osaka 555 0041, Japan
    Exp Eye Res 76:445-52. 2003
    ..Our data demonstrate that 5-HT(2) receptor antagonists including MCI-9042 and M-1 have the neuroprotective effects in cultured RGCs and that MCI-9042 protects against ischemic retinal diseases...
  54. ncbi The 5-hydroxytryptamine2A receptor antagonist sarpogrelate hydrochloride inhibits acute platelet aggregation in injured endothelium
    K Houkin
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Int Med Res 34:65-72. 2006
    ....
  55. ncbi 5-HT2 receptor blocker sarpogrelate prevents downregulation of antiapoptotic protein Bcl-2 and protects the heart against ischemia-reperfusion injury
    Katare Gopalrao Rajesh
    Department of Cardiovascular Thoracic Surgery and Regeneration Technology, Kohasu, Oko, Nankoku, Kochi, 783 8505, Japan
    Life Sci 79:1749-55. 2006
    ..This study thus demonstrates the protective effects of sarpogrelate and supports the role for 5-HT2A inhibition in preventing the reperfusion injury of the heart...
  56. ncbi Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats
    Masayuki Sasaki
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22, Showa, Maebashi, Gunma 371 8511, Japan
    Pain 122:130-6. 2006
    ..p.). These data suggest that 5-HT released in peripheral tissues after thermal injury sensitizes primary afferent neurons and produces mechanical allodynia and thermal hyperalgesia via peripheral 5-HT2A receptors...
  57. ncbi Effects of chronic administration of sarpogrelate on systolic blood pressure of spontaneously hypertensive rats: comparison with quinapril
    Yuki Setoguchi
    Department of Pharmacology, Niigata College of Pharmacy, 5 13 2 Kamishinei cho, Niigata 950 2081, Japan
    Pharmacology 64:71-5. 2002
    ..Thus, quinapril showed hemodynamic effects on WKYs and SHRs, but the 5-HT(2) antagonists sarpogrelate did not shown such effects, suggesting that 5-HT(2) receptor antagonists may not be important for controlling systolic blood pressure...
  58. ncbi Effect of sarpogrelate hydrochloride, a 5-HT2 blocker, on insulin resistance in Otsuka Long-Evans Tokushima fatty rats (OLETF rats), a type 2 diabetic rat model
    Eiko Takishita
    Department of Nutrition, School of Medicine, Tokushima University, Tokushima City, Japan
    J Cardiovasc Pharmacol 43:266-70. 2004
    ..A plasma adrenaline level also rose significantly by injection of the 5-HT and was prevented by pretreatment of sarpogrelate. These results indicate that sarpogrelate improves insulin resistance in type 2 diabetic rats...
  59. ncbi Blockade of 5-HT(2A) receptors by sarpogrelate protects the heart against myocardial infarction in rats
    David Brasil
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre and Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Cardiovasc Pharmacol Ther 7:53-9. 2002
    ..This study examined the effect of sarpogrelate, a 5-HT(2A) receptor blocker, in preventing cardiac dysfunction due to myocardial infarction (MI)...
  60. ncbi Attenuation of the serotonin-induced increase in intracellular calcium in rat aortic smooth muscle cells by sarpogrelate
    Harjot K Saini
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 81:1056-63. 2003
    ....
  61. ncbi Sarpogrelate hydrochloride, a 5-HT2A receptor antagonist, attenuates neurogenic pain induced by nucleus pulposus in rats
    Hiroshi Hashizume
    Department of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan
    Spine (Phila Pa 1976) 32:315-20. 2007
    ..An in vivo study using a rat lumbar disc herniation model...
  62. ncbi 1H NMR studies of aerosol-OT reverse micelles with alkali and magnesium counterions: preparation and analysis of MAOTs
    Michelle L Stahla
    Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523 1872, USA
    Langmuir 24:6027-35. 2008
    ..This work thus extends the potential use of MAOT microemulsions for applications such as in green chemistry...
  63. ncbi Temperature-dependent solvation dynamics of water in sodium bis(2-ethylhexyl)sulfosuccinate/isooctane reverse micelles
    Rajib Kumar Mitra
    Unit for Nano Science and Technology, Department of Chemical, Biological, and Macromolecular Sciences, S N Bose National Center for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata, India
    Langmuir 24:49-56. 2008
    ..Time-resolved fluorescence anisotropy studies reveal a decrease in the rotational restriction on the probe with increasing temperature for all systems. Wobbling-in-cone analysis of the anisotropy data also supports this finding...
  64. ncbi Electrochemical extraction of proteins by reverse micelle formation
    Mariko Shinshi
    Department of Chemistry, Faculty of Science, Kobe University, Nada, Kobe 657 8501, Japan
    Langmuir 22:5937-44. 2006
    ..4. At pH 7.0, when formation of unfilled reverse micelles occurred simultaneously, the protein-AOT complexes appeared to be stabilized, probably via fusion with unfilled reverse micelles...
  65. ncbi pH-dependent chiral vesicles from enantiomeric sodium 2,3-bis(decyloxy) succinate in aqueous solution
    B Vijai Shankar
    Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India
    Langmuir 23:3523-9. 2007
    ..The vesicles were found to be pH sensitive, were stable in the pH range 6-8, and formed the insoluble diacid at acidic pH due to protonation of the carboxylate head groups...
  66. ncbi High-performance liquid chromatography-post-column chemiluminescence determination of aminopolycarboxylic acids at low concentration levels using tris(2,2'-bipyridyl)ruthenium(III)
    Tomás Pérez-Ruiz
    Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071 Murcia, Spain
    J Chromatogr A 1169:151-7. 2007
    ..The lowest amounts measurable were: 75 pg for NTA, 0.7 ng for EDDS, 0.8 ng for DTPA and 12ng for EDTA. The method was also applied for the EDTA assay in canned foods...
  67. ncbi The effect of operating variables on chelant-assisted remediation of contaminated dredged sediment
    A Polettini
    Department of Hydraulics, Transportation and Roads, University of Rome La Sapienza, Via Eudossiana 18 00184 Rome, Italy
    Chemosphere 66:866-77. 2007
    ....
  68. ncbi An evaluation of the green chelant EDDS to enhance the stability of hydrogen peroxide in the presence of aquifer solids
    Xiuyuan Xu
    Department of Civil and Environmental Engineering, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1
    Chemosphere 69:755-62. 2007
    ....
  69. ncbi Ryegrass uptake of soil Cu/Zn induced by EDTA/EDDS together with a vertical direct-current electrical field
    Dong Mei Zhou
    State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China
    Chemosphere 67:1671-6. 2007
    ..The shoot Cu concentration of ryegrass in the treatments with EDTA/EDDS and electrical field together was 0.46/0.61 times higher than that in treatments without electrical fields...
  70. ncbi Prospective double-blind randomized study of the effects of four intravenous fluids on platelet function and hemostasis in elective hip surgery
    P A Evans
    Accident and Emergency Department, Morriston Hospital, Swansea, UK
    J Thromb Haemost 1:2140-8. 2003
    ..Inhibition of platelet aggregation by certain colloids may provide additional protection against the increased thrombotic risk in patients following major surgery...
  71. ncbi Determination of N,N'-ethylenebisstearamide additive in polymer by normal phase liquid chromatography with evaporative light scattering detection
    Karen Gaudin
    Laboratoire de Chimie Analytique, PPF Médicament Parasitologie, UFR Pharmacie, Universite Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    J Chromatogr A 1167:27-34. 2007
    ..The intra-day and day-to-day precisions of extraction method were equal to 9.1% and 9.9%, respectively...
  72. ncbi [Refractory hypoxemia treated early by HFO in a severe traumatic brain injury patient]
    L Bellamy
    Pôle anesthésie réanimation Samu, CHU de la Cavale Blanche, Brest, France
    Ann Fr Anesth Reanim 26:685-7. 2007
    ..The introduction of high-frequency oscillatory ventilation permitted a respiratory improvement in 48 hours and a good neurological outcome...
  73. ncbi A comparison of the haemodynamic effects of 4% succinylated gelatin, 6% hydroxyethyl starch (200/0.5) and 4% human albumin after cardiac surgery
    A Kuitunen
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Meilahti Hospital, Helsinki, Finland
    Scand J Surg 96:72-8. 2007
    ..We hypothesized that a short term infusion of hydroxyethyl starch results in better haemodynamic response than an infusion of lower molecular weight gelatin...
  74. ncbi Hydroxyethylstarch 200 and 240 differently affect aortic distensibility but not viscosity and blood pressure upon acute isovolumic hemodilution
    Alexis Caron
    Laboratory of Hematology and Physiology, EA 3452, Faculty of Pharmacy, University Henri Poincare, Nancy, France
    Clin Hemorheol Microcirc 35:447-58. 2006
    ....
  75. ncbi Reversal of diuretic-induced hepatic encephalopathy with infusion of albumin but not colloid
    Rajiv Jalan
    Liver Failure Group, Institute of Hepatology, University College London Medical School, London WC1E 6HX, UK
    Clin Sci (Lond) 106:467-74. 2004
    ..These data support the notion that other factors, such as oxidative stress, act as adjuncts to ammonia in the pathogenesis of diuretic-induced HE and suggest a possible role for albumin infusion in its treatment...
  76. ncbi Randomized study comparing the effects of hydroxyethyl starch solution with Gelofusine on pulmonary function in patients undergoing abdominal aortic aneurysm surgery
    D Rittoo
    Department of Vascular Surgery, Selly Oak Hospital, University Hospital Birmingham NHS Trust, Raddlebarn Road, Selly Oak, Birmingham B29 6JD, UK
    Br J Anaesth 92:61-6. 2004
    ..We compared the effects of HES solution with those of Gelofusine solution on pulmonary function, microvascular permeability and neutrophil activation in patients undergoing elective infrarenal abdominal aortic aneurysm surgery...
  77. ncbi Artificial colloids impair haemostasis. An in vitro study using thromboelastometry coagulation analysis
    T T Niemi
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Acta Anaesthesiol Scand 49:373-8. 2005
    ..Munich, Germany) in serial in vitro haemodilutions of colloids...
  78. ncbi Anaphylaxis to Gelofusine confirmed by in vitro basophil activation test: a case series
    E Apostolou
    Department of Immunology, Monash University, Commercial Road, Melbourne VIC 3004, Australia
    Anaesthesia 61:264-8. 2006
    ..5%. Our findings suggest that basophil activation testing is a safe and reliable in vitro assay for prediction or confirmation of Gelofusine sensitivity in patients with high clinical suspicion of Gelofusine-induced anaphylaxis...
  79. ncbi The effects of hydroxyethyl starch compared with gelofusine on activated endothelium and the systemic inflammatory response following aortic aneurysm repair
    D Rittoo
    Department of Vascular Surgery, Selly Oak Hospital, Selly Oak, Birmingham B29 6JD, UK
    Eur J Vasc Endovasc Surg 30:520-4. 2005
    ..To investigate the effect of HES, used as a plasma volume expander, on endothelial cell activation induced by ischaemia-reperfusion in humans...
  80. ncbi Splanchnic oxygenation in patients undergoing abdominal aortic aneurysm repair and volume expansion with eloHAES
    D Rittoo
    Department of Vascular Surgery, Biochemistry, Anaesthetics and Intensive Care, Selly Oak Hospital, University Hospital Birmingham NHS Trust, Raddlebarn Road, Selly Oak, Birmingham B29 6JD, UK
    Cardiovasc Surg 10:128-33. 2002
    ..Gastric intramucosal pH (pHi), a surrogate marker of splanchnic oxygenation, falls following abdominal aortic aneurysm surgery...
  81. ncbi Oxygen transport and myocardial function after the administration of albumin 5%, hydroxyethylstarch 6% and succinylated gelatine 4% to rabbits
    D G Himpe
    Middelheim General Hospital, Department of Anaesthesia and Intensive Care, Antwerp, Belgium
    Eur J Anaesthesiol 19:860-7. 2002
    ....
  82. ncbi Effects of albumin 5% and artificial colloids on clot formation in small infants
    T Haas
    Department of Anaesthesiology and Intensive Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Anaesthesia 62:1000-7. 2007
    ..From a haemostatic point of view it might be preferable to use gelatine solution as an alternative to albumin; HES showed the greatest effects on the overall coagulation process...
  83. ncbi Randomized controlled study of colloid preload before spinal anaesthesia for caesarean section
    W D Ngan Kee
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin
    Br J Anaesth 87:772-4. 2001
    ..Colloid preload improved haemodynamic stability but did not affect neonatal outcome when arterial pressure was maintained with an infusion of metaraminol during spinal anaesthesia for Caesarean section...
  84. ncbi Use of animal products in vegetarians and others
    S Sarkar
    Anaesthesia 60:519-20. 2005
  85. ncbi Prediction of volatile anaesthetic solubility in blood and priming fluids for extracorporeal circulation
    R G Yu
    Department of Anesthesiology, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China
    Br J Anaesth 86:338-44. 2001
    ..During normothermic CPB, blood solubility of volatile anaesthetics would be unchanged when using plasma, slightly reduced when using banked blood and markedly reduced when using crystalloids and colloids...
  86. ncbi The gelatin-derived plasma substitute Gelofusine causes low-molecular-weight proteinuria by decreasing tubular protein reabsorption
    M A ten Dam
    Department of Internal Medicine, Division of Nephrology, University Hospital Nijmegen St Radboud, Nijmegen, The Netherlands
    J Crit Care 16:115-20. 2001
    ..This effect is most likely due to competitive inhibition of tubular protein reabsorption...
  87. ncbi Is coating of tubing required when endothelin-1 is infused intravenously?
    Tycho Vuurmans
    Nephrol Dial Transplant 18:1677-8. 2003
  88. ncbi The use of basophil activation to diagnose allergy to Gelofusine
    M O Shields
    Anaesthesia 61:716-7; author reply 717-8. 2006
  89. ncbi Anaphylaxis to Haemaccel and cross reactivity to Gelofusin
    W J Russell
    Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital, South Australia
    Anaesth Intensive Care 30:481-3. 2002
    ..It appears that patients who are known to be allergic to Haemaccel are probably allergic also to Gelofusin. Both patients have been given new Medic Alert bracelets stating "Allergic to Haemaccel and Gelofusin"...
  90. pmc Gelofusine allergy--the need for identification jewellery
    S C Jenkins
    Department of Surgery, Princess Alexandra Hospital, Harlow, Essex, UK
    Ann R Coll Surg Engl 84:206-7. 2002
    ..A case of anaphylactoid reaction due solely to the use of Gelofusine in a patient with non-haemorrhagic hypovolaemia is presented, with a discussion on the management and the use of allergy identification jewellery...
  91. ncbi Determining the molar mass of a plasma substitute succinylated gelatin by size exclusion chromatography-multi-angle laser light scattering, sedimentation equilibrium and conventional size exclusion chromatography
    Manjit Kaur
    Institute of Pharmaceutical Sciences Research, School of Pharmacy, University of Nottingham, UK
    J Chromatogr A 957:139-48. 2002
    ..The problems associated with the preparation of succinylated gelatin fractions suggest that an absolute method such as SEC-MALLS may be a more suitable choice for determining the M(w) in succinylated gelatins...
  92. ncbi Blockage of a fluid administration set
    O W Pratt
    Anaesthesia 59:829; author reply 829-30. 2004
  93. ncbi Antiviral activity of characterized extracts from echinacea spp. (Heliantheae: Asteraceae) against herpes simplex virus (HSV-I)
    S E Binns
    Department of Biology, University of Ottawa, Ottawa, Canada
    Planta Med 68:780-3. 2002
    ..The most potent inhibitors of HSV were E. pallida var. sanguinea crude (70 % ethanol) inflorescence extract (MIC = 0.026 mg/mL), cichoric acid (MIC = 0.045 mg/mL) and Echinacea purpurea n-hexane root extract (MIC = 0.12 mg/mL)...
  94. ncbi L-chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro
    Ryan A Reinke
    Department of Microbiology and Molecular Genetics, University of California, Irvine 92697 4800, USA
    Virology 326:203-19. 2004
    ..These data demonstrate that l-CA is a noncompetitive but reversible inhibitor of IN in vitro and of HIV integration in vivo. Thus, l-CA likely interacts with amino acids other than those which bind substrate...
  95. ncbi Genetic diversity in seed populations of Echinacea purpurea controls the capacity for regeneration, route of morphogenesis and phytochemical composition
    Susan J Murch
    Department of Chemistry, I K Barber School of Arts and Sciences, University of British Columbia, Okanagan, Kelowna, British Columbia, Canada, V1V 1V7
    Plant Cell Rep 25:522-32. 2006
    ..Together, these demonstrate the potential for selective breeding of elite, highly regenerative, chemically superior, clonally propagated varieties from the naturally occurring genetic variability in the seed populations of E. purpurea...
  96. ncbi Human gene expression as a tool to determine horticultural maturity in a bioactive plant (Echinacea purpurea L. Moench)
    Ernesto Antonio Brovelli
    Nutrilite Health Institute, 19600 6th Street, Lakeview, California 92567, USA
    J Agric Food Chem 53:8156-61. 2005
    ..These findings suggest that the use of gene expression may be an effective tool not only to standardize botanical extracts but also to optimize harvest time...
  97. ncbi Phytochemical variation in echinacea from roots and flowerheads of wild and cultivated populations
    Shannon E Binns
    Biology Department, University of Ottawa, P O Box 450 Station A, Ontario, Canada K1N 6N5
    J Agric Food Chem 50:3673-87. 2002
    ..purpurea. Baseline phytochemical data and chromatographic profiles for all types of wild Echinacea may be used for protection of wild stands, germplasm identification, and crop improvement...
  98. ncbi Stabilization of caffeic acid derivatives in Echinacea purpurea L. glycerin extract
    Chantal Bergeron
    Tom s of Maine, 302 Lafayette Center, P O Box 710, Kennebunk, Maine 04043, USA
    J Agric Food Chem 50:3967-70. 2002
    ..2-O-Feruloyl-tartaric acid was stable during the whole testing period. All antioxidant treatments greatly improved the stability of caffeic acid derivatives. Stability was dependent upon the concentration of antioxidant added...
  99. ncbi Synergistic antioxidative effects of alkamides, caffeic acid derivatives, and polysaccharide fractions from Echinacea purpurea on in vitro oxidation of human low-density lipoproteins
    Lea Dalby-Brown
    Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 København Ø, Denmark
    J Agric Food Chem 53:9413-23. 2005
    ..This contributes to the hypothesis that the physiologically beneficial effects of Echinacea are exerted by the multitude of constituents present in the preparations...
  100. ncbi Free-radical-mediated conjugate additions. Enantioselective synthesis of butyrolactone natural products: (-)-enterolactone, (-)-arctigenin, (-)-isoarctigenin, (-)-nephrosteranic acid, and (-)-roccellaric acid
    Mukund P Sibi
    Department of Chemistry, North Dakota State University, Fargo, North Dakota 58105 5516, USA
    J Org Chem 67:1738-45. 2002
    ..conjugate addition of alkyl radicals to a differentially protected fumarate 10 produced the monoalkylated succinates with high chemical efficiency and excellent stereoselectivity...
  101. ncbi Effects of chemical modification of nitrobenzylthioinosine on its binding to high-affinity membrane binding sites and inhibition of nucleoside transport
    B Ziemnicka-Merchant
    Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, IL 60064 3500
    Biochem Pharmacol 44:1577-83. 1992
    ..Attachment of succinates at both the 3' and 5'-positions almost completely abolished both binding to high-affinity sites and inhibition ..

Research Grants97

  1. West Virginia Ideal Networks of Biomedical Research Exc*
    GARY RANKIN; Fiscal Year: 2005
    ....
  2. CHEMICAL INDUCED NEPHROTOXICITY--SUCCINIMIDES
    GARY RANKIN; Fiscal Year: 1999
    ..Collectively, the results of these studies should add important, new knowledge about the nephrotoxic and urotoxic species of succinimides, cellular targets of the toxicant species and potential mechanisms of nephrotoxicity. ..
  3. CHEMICAL INDUCED NEPHROTOXICITY--SUCCINIMIDES
    GARY RANKIN; Fiscal Year: 2001
    ..Collectively, the results of these studies should add important, new knowledge about the nephrotoxic and urotoxic species of succinimides, cellular targets of the toxicant species and potential mechanisms of nephrotoxicity. ..
  4. CHEMICAL-INDUCED NEPHROTOXICITY--SUCCINIMIDES
    GARY RANKIN; Fiscal Year: 1992
    ....
  5. CHEMICAL-INDUCED NEPHROTOXICITY: SUCCINIMIDES
    GARY RANKIN; Fiscal Year: 1990
    ....
  6. CHEMICAL INDUCED NEPHROTOXICITY--SUCCINIMIDES
    GARY RANKIN; Fiscal Year: 2000
    ..Collectively, the results of these studies should add important, new knowledge about the nephrotoxic and urotoxic species of succinimides, cellular targets of the toxicant species and potential mechanisms of nephrotoxicity. ..
  7. CHEMICAL-INDUCED NEPHROTOXICITY--SUCCINIMIDES
    GARY RANKIN; Fiscal Year: 1993
    ....
  8. West Virginia Ideal Networks of Biomedical Research Exc*
    GARY RANKIN; Fiscal Year: 2006
    ....
  9. West Virginia Ideal Networks of Biomedical Research Exc*
    GARY RANKIN; Fiscal Year: 2004
    ....
  10. West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)
    GARY RANKIN; Fiscal Year: 2009
    ..An important thrust of this program is directed toward enhancing the pipeline of undergraduate students choosing a career in the biomedical science research field. ..
  11. West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)
    GARY RANKIN; Fiscal Year: 2009
    ..An important thrust of this program is directed toward enhancing the pipeline of undergraduate students choosing a career in the biomedical science research field. ..
  12. West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)
    GARY RANKIN; Fiscal Year: 2009
    ..An important thrust of this program is directed toward enhancing the pipeline of undergraduate students choosing a career in the biomedical science research field. ..
  13. West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)
    GARY RANKIN; Fiscal Year: 2009
    ..An important thrust of this program is directed toward enhancing the pipeline of undergraduate students choosing a career in the biomedical science research field. ..
  14. West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)
    Gary O Rankin; Fiscal Year: 2010
    ..An important thrust of this program is directed toward enhancing the pipeline of undergraduate students choosing a career in the biomedical science research field. ..
  15. West Virginia Ideal Networks of Biomedical Research Exc*
    GARY RANKIN; Fiscal Year: 2008
    ....
  16. West Virginia Ideal Networks of Biomedical Research Exc*
    GARY RANKIN; Fiscal Year: 2007
    ....
  17. Development of Reagents for Labeling with At-211
    DANIEL WILBUR; Fiscal Year: 2006
    ..abstract_text> ..
  18. Development of Reagents for Labeling with At-211
    DANIEL WILBUR; Fiscal Year: 2007
    ..abstract_text> ..
  19. Development of At-211-Labeled Reagents for Therapy of Metastatic Prostate Cancer
    DANIEL SCOTT WILBUR; Fiscal Year: 2010
    ..The proposed research will develop new and unique At-211-labeled reagents that have the potential to dramatically improve the five-year survival of prostate cancer patients with metastatic disease. ..
  20. Development of Reagents for Labeling with At-211
    DANIEL WILBUR; Fiscal Year: 2005
    ..abstract_text> ..
  21. Involvement of Na/Dicarboxylate Cotransporter in Aging
    Ana Pajor; Fiscal Year: 2002
    ..abstract_text> ..
  22. Development of Reagents for Labeling with At-211
    DANIEL WILBUR; Fiscal Year: 2008
    ..abstract_text> ..
  23. Matrix Metalloproteinases and the Blood-Brain Barrier
    Gary Rosenberg; Fiscal Year: 2004
    ..Understanding the molecular events in the BBB disruption by MMPs will provide a rational basis for drug design, and will lead to novel treatments in many important neurological diseases. ..
  24. Stabilization of Membrane Protein Signaling Complexes
    T M Iverson; Fiscal Year: 2010
    ..This proposal focuses on investigating solubilization reagents for membrane proteins that mimic biological membranes and improve complex affinity. ..
  25. GLYCOCONJUGATES IN VIRAL PATHOGENESIS
    GILLIAN AIR; Fiscal Year: 2003
    ..abstract_text> ..
  26. CALCIFICATION OF ELASTIN-- MECHANISMS AND PREVENTION
    Naren Vyavahare; Fiscal Year: 2003
    ..The in vitro studies will include elastin conformational studies with FT-IR, NMR and circular dichroism spectroscopies, study of elastin-MMP interactions by surface plasmon resonance analysis and elastolysis experiments with MMPS. ..
  27. Pathobiology of Vascular Cognitive Impairment
    Gary Rosenberg; Fiscal Year: 2009
    ..These studies will determine the role of protease-mediated nflammation in the progressive form of SIVD, and could lead to novel treatments to suppress proteases. ..
  28. Human & mouse antibodies against influenza virus
    GILLIAN AIR; Fiscal Year: 2008
    ..The knowledge gained will be applicable to a new subtype of influenza if and when a new pandemic begins. ..
  29. Calcification of Elastin: Mechanisms and Prevention
    Naren Vyavahare; Fiscal Year: 2006
    ..Long-term objective of our program is to understand the mechanistic pathways of elastin calcification so that it can be prevented or reversed. The following specific aims will be pursued in this continuation program. ..
  30. Human & mouse antibodies against influenza virus
    Gillian M Air; Fiscal Year: 2010
    ..The knowledge gained will be applicable to a new subtype of influenza if and when a new pandemic begins. ..
  31. CALCIFICATION OF ELASTIN-- MECHANISMS AND PREVENTION
    Naren Vyavahare; Fiscal Year: 2002
    ..The in vitro studies will include elastin conformational studies with FT-IR, NMR and circular dichroism spectroscopies, study of elastin-MMP interactions by surface plasmon resonance analysis and elastolysis experiments with MMPS. ..
  32. GLUCOSE/SECRETAGOGUE METABOLISM IN PANCREATIC ISLETS
    MICHAEL JOHN MACDONALD; Fiscal Year: 2010
    ....
  33. Reasons for poor durability of resin-dentin bonds
    David Pashley; Fiscal Year: 2004
    ..This comprehensive approach to improving the durability of resin-dentin bonds should ultimately save billions of dollars in health care and much human suffering. ..
  34. GLUCOSE/SECRETAGOGUE METABOLISM IN PANCREATIC ISLETS
    Michael MacDonald; Fiscal Year: 2003
    ..abstract_text> ..
  35. Acute Renal Failure: Mechanisms and Adaptive Responses
    RICHARD ZAGER; Fiscal Year: 2007
    ....
  36. Defining an HIV Integrase Inhibitor Binding Pocket
    William Robinson; Fiscal Year: 2004
    ..Moreover, by understanding the nature of inhibitor resistance, new molecules with activity against inhibitor-resistant HIV can be designed and synthesized. ..
  37. Metal-Mediated Routes to Biaryls
    Bruce Lipshutz; Fiscal Year: 2005
    ..A particular, albeit representative, application of a novel substituted cyclo-NOBIN will be studied for selected asymmetric aldol reactions. ..
  38. New Technologies for Catalysis in Water
    Bruce Lipshutz; Fiscal Year: 2009
    ..This technology also is to be applied to other important cross-couplings, such as aminations and asymmetric additions of hydride to Michael acceptors, all in water at room temperature. ..
  39. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  40. Glucose/Secreatogogue Metabolism in Pancreatic islets
    Michael MacDonald; Fiscal Year: 2007
    ..Resulting decreases in insulin release will be compared with alterations in metabolic pathways. In Aim 2B limited focused studies of beta ceil cataplerosis in type 2 diabetes will be performed. ..
  41. Glucose/Secreatogogue Metabolism in Pancreatic islets
    Michael MacDonald; Fiscal Year: 2005
    ..Resulting decreases in insulin release will be compared with alterations in metabolic pathways. In Aim 2B limited focused studies of beta ceil cataplerosis in type 2 diabetes will be performed. ..
  42. Reasons for poor durability of resin-dentin bonds
    David Pashley; Fiscal Year: 2007
    ..This comprehensive approach to improving the durability of resin-dentin bonds should ultimately save billions of dollars in health care and much human suffering. ..
  43. Metal-Mediated Routes to Biaryls
    Bruce Lipshutz; Fiscal Year: 2004
    ..A particular, albeit representative, application of a novel substituted cyclo-NOBIN will be studied for selected asymmetric aldol reactions. ..
  44. NEW INHIBITORS FOR THE PENICILLIN BINDING PROTEINS
    WILLIAM GUTHEIL; Fiscal Year: 2002
    ..These studies will established improved methods for the study of the PBPs, determine essential features of PBP substrate specificity, and use this information to design new PBP inhibitors. ..
  45. CHEMISTRY AND BIOLOGY OF INSULIN-LIKE VANADIUM COMPOUNDS
    DEBBIE CRANS; Fiscal Year: 2000
    ..The proposed studies will lead to an in-depth understanding of both the chemical and pharmacological properties of known and new vanadium compounds inducing insulin-like action. ..
  46. FINE TUNING BINOLS AND BINAPS FOR ASYMMETRIC SYNTHESIS
    Bruce Lipshutz; Fiscal Year: 2000
    ..From ligands of this type come further options, such as opportunities for polymer mounting, and potentially of greatest attention, conversion to substituted cyclo BINAPs. ..
  47. PHOSPHOINOSITIDE HYDROLYSIS & BETA CELL SECRETION
    Walter Zawalich; Fiscal Year: 1993
    ..Biochemical events activated by or associated with cellular increases in PI hydrolysis are implicated in these processes and our goal is to explore these interrelationships...
  48. GLUCOSE/SECRETAGOGUE METABOLISM IN PANCREATIC ISLETS
    Michael MacDonald; Fiscal Year: 1999
    ..abstract_text> ..
  49. EXITING STATIONARY PHASE IN E COLI
    Deborah Siegele; Fiscal Year: 2001
    ..Standard molecular methods, such as Northern blots and fusions to reporter genes, will be used to characterize how expression is the outgrowth-specific genes is controlled. ..
  50. NATURALLY OCCURRING POLYENES VIA ORGANOMETALLICS
    Bruce Lipshutz; Fiscal Year: 2002
    ..abstract_text> ..
  51. GLUCOSE/SECRETAGOGUE METABOLISM IN PANCREATIC ISLETS
    Michael MacDonald; Fiscal Year: 2002
    ..abstract_text> ..
  52. CHEMISTRY AND BIOLOGY OF INSULIN-LIKE VANADIUM COMPOUNDS
    DEBBIE CRANS; Fiscal Year: 2001
    ..The proposed studies will lead to an in-depth understanding of both the chemical and pharmacological properties of known and new vanadium compounds inducing insulin-like action. ..
  53. Acute Renal Failure: Mechanisms and Adaptive Responses
    RICHARD ZAGER; Fiscal Year: 2008
    ....
  54. CHEMISTRY AND BIOLOGY OF INSULIN-LIKE VANADIUM COMPOUNDS
    DEBBIE CRANS; Fiscal Year: 2002
    ..The proposed studies will lead to an in-depth understanding of both the chemical and pharmacological properties of known and new vanadium compounds inducing insulin-like action. ..
  55. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2004
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  56. CHEMISTRY AND BIOLOGY OF INSULIN-LIKE VANADIUM COMPOUNDS
    DEBBIE CRANS; Fiscal Year: 2001
    ..The proposed studies will lead to an in-depth understanding of both the chemical and pharmacological properties of known and new vanadium compounds inducing insulin-like action. ..
  57. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  58. Pretargeting mouse tumor with anti-PSMA antibody-MORF
    Guozheng Liu; Fiscal Year: 2005
    ..Based on our experiences in this pretargeting strategy, we are confident that these investigations on the pretargeting imaging of prostate cancer models with MORFs will be successful. ..
  59. ACUTE RENAL FAILURE--MECHANISMS AND ADAPTIVE RESPONSES
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  60. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2000
    ....
  61. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2005
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  62. ACUTE RENAL FAILURE--MECHANISMS AND ADAPTIVE RESPONSES
    RICHARD ZAGER; Fiscal Year: 2000
    ....
  63. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2006
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  64. MECHANISMS IN MYOGLOBINURIC ACUTE RENAL FAILURE
    RICHARD ZAGER; Fiscal Year: 1993
    ..By addressing the above, new insights into heme protein/low molecular weight protein nephrotoxicity and shock-induced renal damage will be obtained which should have direct relevance to crush syndrome induced ARF...
  65. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 1999
    ....
  66. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2007
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  67. ACUTE RENAL FAILURE--MECHANISMS AND ADAPTIVE RESPONSES
    RICHARD ZAGER; Fiscal Year: 1999
    ....
  68. CHEMISTRY AND BIOLOGY OF INSULIN-LIKE VANADIUM COMPOUNDS
    DEBBIE CRANS; Fiscal Year: 2003
    ..The proposed studies will lead to an in-depth understanding of both the chemical and pharmacological properties of known and new vanadium compounds inducing insulin-like action. ..