calcium oxalate

Summary

Summary: The calcium salt of oxalic acid, occurring in the urine as crystals and in certain calculi.

Top Publications

  1. ncbi The effect of different diets on urine composition and the risk of calcium oxalate crystallisation in healthy subjects
    Roswitha Siener
    Division of Experimental Urology, Department of Urology, University of Bonn, Sigmund Freud Street, 25, D 53105, Bonn, Germany
    Eur Urol 42:289-96. 2002
  2. pmc Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion
    Shrikant R Mulay
    Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Munich, Germany
    J Clin Invest 123:236-46. 2013
  3. ncbi Calcium oxalate in plants: formation and function
    Vincent R Franceschi
    School of Biological Sciences, Washington State University, Pullman, Washington 99164 4236, USA
    Annu Rev Plant Biol 56:41-71. 2005
  4. ncbi Are calcium oxalate crystals involved in the mechanism of acute renal failure in ethylene glycol poisoning?
    Kenneth McMartin
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Clin Toxicol (Phila) 47:859-69. 2009
  5. pmc Kidney stone disease
    Fredric L Coe
    Renal Section, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 115:2598-608. 2005
  6. ncbi The role of overweight and obesity in calcium oxalate stone formation
    Roswitha Siener
    Division of Experimental Urology, Department of Urology, University of Bonn, Bonn, Germany
    Obes Res 12:106-13. 2004
  7. ncbi Cooperation of phosphates and carboxylates controls calcium oxalate crystallization in ultrafiltered urine
    Bernd Grohe
    Department of Dentistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada
    Urol Res 39:327-38. 2011
  8. pmc Recent advances in the pathophysiology of nephrolithiasis
    Khashayar Sakhaee
    Department of Internal Medicine, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8885, USA
    Kidney Int 75:585-95. 2009
  9. ncbi Essential arterial hypertension and stone disease
    L Borghi
    Institutes of Semeiotica Medica, University of Parma, Italy
    Kidney Int 55:2397-406. 1999
  10. ncbi Expression of osteopontin in rat kidneys: induction during ethylene glycol induced calcium oxalate nephrolithiasis
    Saeed R Khan
    Department of Pathology, College of Medicine, University of Florida, Gainesville, Florida, USA
    J Urol 168:1173-81. 2002

Research Grants

Detail Information

Publications317 found, 100 shown here

  1. ncbi The effect of different diets on urine composition and the risk of calcium oxalate crystallisation in healthy subjects
    Roswitha Siener
    Division of Experimental Urology, Department of Urology, University of Bonn, Sigmund Freud Street, 25, D 53105, Bonn, Germany
    Eur Urol 42:289-96. 2002
    The aim of the study was to determine the impact of defined diet modifications on urine composition and the risk of calcium oxalate crystallisation.
  2. pmc Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion
    Shrikant R Mulay
    Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Munich, Germany
    J Clin Invest 123:236-46. 2013
    Nephrocalcinosis, acute calcium oxalate (CaOx) nephropathy, and renal stone disease can lead to inflammation and subsequent renal failure, but the underlying pathological mechanisms remain elusive...
  3. ncbi Calcium oxalate in plants: formation and function
    Vincent R Franceschi
    School of Biological Sciences, Washington State University, Pullman, Washington 99164 4236, USA
    Annu Rev Plant Biol 56:41-71. 2005
    b>Calcium oxalate (CaOx) crystals are distributed among all taxonomic levels of photosynthetic organisms from small algae to angiosperms and giant gymnosperms. Accumulation of crystals by these organisms can be substantial...
  4. ncbi Are calcium oxalate crystals involved in the mechanism of acute renal failure in ethylene glycol poisoning?
    Kenneth McMartin
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Clin Toxicol (Phila) 47:859-69. 2009
    ..The mechanism has not been established but is thought to result from the production of a toxic metabolite...
  5. pmc Kidney stone disease
    Fredric L Coe
    Renal Section, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 115:2598-608. 2005
    ..Approximately 80% of stones are composed of calcium oxalate (CaOx) and calcium phosphate (CaP); 10% of struvite (magnesium ammonium phosphate produced during infection ..
  6. ncbi The role of overweight and obesity in calcium oxalate stone formation
    Roswitha Siener
    Division of Experimental Urology, Department of Urology, University of Bonn, Bonn, Germany
    Obes Res 12:106-13. 2004
    The aim of the study was to assess the influence of overweight and obesity on the risk of calcium oxalate stone formation.
  7. ncbi Cooperation of phosphates and carboxylates controls calcium oxalate crystallization in ultrafiltered urine
    Bernd Grohe
    Department of Dentistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada
    Urol Res 39:327-38. 2011
    ..present study, we investigate the roles of phosphate and carboxylate groups in the OPN-mediated modulation of calcium oxalate (CaOx), the principal mineral phase found in kidney stones...
  8. pmc Recent advances in the pathophysiology of nephrolithiasis
    Khashayar Sakhaee
    Department of Internal Medicine, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8885, USA
    Kidney Int 75:585-95. 2009
    ..link between uric acid nephrolithiasis and the metabolic syndrome, the role of Oxalobacter formigenes in calcium oxalate stone formation, oxalate transport in Slc26a6-null mice, the potential pathogenetic role of Randall's plaque ..
  9. ncbi Essential arterial hypertension and stone disease
    L Borghi
    Institutes of Semeiotica Medica, University of Parma, Italy
    Kidney Int 55:2397-406. 1999
    ..Cross-sectional studies have shown that nephrolithiasis is more frequently found in hypertensive patients than in normotensive subjects, but the pathogenic link between hypertension and stone disease is still not clear...
  10. ncbi Expression of osteopontin in rat kidneys: induction during ethylene glycol induced calcium oxalate nephrolithiasis
    Saeed R Khan
    Department of Pathology, College of Medicine, University of Florida, Gainesville, Florida, USA
    J Urol 168:1173-81. 2002
    ..is a well-known component of stone matrix and a strong inhibitor of the nucleation, growth and aggregation of calcium oxalate crystals in vitro...
  11. pmc Diet, but not oral probiotics, effectively reduces urinary oxalate excretion and calcium oxalate supersaturation
    John C Lieske
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 78:1178-85. 2010
    ..effect of a controlled diet and two probiotic preparations on urinary oxalate excretion, a risk factor for calcium oxalate kidney stone formation, in patients with mild hyperoxaluria...
  12. ncbi Estrogen replacement increased the citrate and calcium excretion rates in postmenopausal women with recurrent urolithiasis
    Jayant Dey
    Department of Endocrinology, Ochsner Clinic, Tulane University, New Orleans, Louisiana, USA
    J Urol 167:169-71. 2002
    ..We investigated the role of menopausal estrogen replacement therapy on the urinary constituents and characteristics that may influence recurrent calcium oxalate stone disease.
  13. ncbi Role of renal epithelial cells in the initiation of calcium oxalate stones
    Saeed R Khan
    Department of Pathology, College of Medicine, University of Florida, Gainesville 32610 0275, USA
    Nephron Exp Nephrol 98:e55-60. 2004
    ..Elevated levels of oxalate and calcium oxalate crystals, however, provoke renal cells to increase the synthesis of osteopontin, bikunin, heparan sulfate ..
  14. ncbi Oxidative renal cell injury induced by calcium oxalate crystal and renoprotection with antioxidants: a possible role of oxidative stress in nephrolithiasis
    Mauricio Davalos
    Department of Urology, New York Medical College, Valhalla, New York 10595, USA
    J Endourol 24:339-45. 2010
    b>Calcium oxalate (CaOx) is one of the key elements for kidney stone formation, but the exact mechanism needs to be defined...
  15. pmc Three pathways for human kidney stone formation
    Fredric L Coe
    Department of Medicine, University of Chicago, Nephrology Section MC 5100, 5841 South Maryland Avenue, Chicago, IL, 60637, USA
    Urol Res 38:147-60. 2010
    ..The first pathway is overgrowth on interstitial apatite plaque as seen in idiopathic calcium oxalate stone formers, as well as stone formers with primary hyperparathyroidism, ileostomy, and small bowel ..
  16. ncbi Metabolic risk factors in pediatric and adult calcium oxalate urinary stone formers: is there any difference?
    Ahmet Tefekli
    Department of Urology, Medical Faculty of Istanbul, University of Istanbul, Turkey
    Urol Int 70:273-7. 2003
    ..The aim of this study is to compare the metabolic risk factors and saturation of urine in pediatric and adult calcium oxalate (Ca-Ox) stone formers.
  17. ncbi Decreased inhibitory activity of prothrombin to calcium oxalate crystallization by specific chemical modification of its gamma-carboxyglutamic acid residues
    Jihong Liu
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Urology 67:201-3. 2006
    To investigate the inhibitory role of gamma (gamma)-carboxyglutamic acid (Gla) in the Gla domain of urinary prothrombin in the formation of calcium oxalate crystals.
  18. ncbi Influence of cranberry juice on the urinary risk factors for calcium oxalate kidney stone formation
    T McHarg
    Department of Medicine, University of Cape Town, Cape Town, South Africa
    BJU Int 92:765-8. 2003
    ..the potential influence of cranberry juice on urinary biochemical and physicochemical risk factors associated with the formation of calcium oxalate kidney stones, as this product might affect the chemical composition of urine.
  19. ncbi Unique calcium oxalate "duplex" and "concretion" idioblasts in leaves of tribe Naucleeae (Rubiaceae)
    Nels R Lersten
    Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, IA 50011 1020, USA
    Am J Bot 98:1-11. 2011
    ..Here, we surveyed Naucleeae (103 of 179 species, 23 of 24 genera, all seven subtribes) for "duplex idioblast" distribution for systematic significance and describe examples of this rare feature...
  20. pmc Calcium oxalate stone formation in the inner ear as a result of an Slc26a4 mutation
    Amiel A Dror
    Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 285:21724-35. 2010
    b>Calcium oxalate stone formation occurs under pathological conditions and accounts for more than 80% of all types of kidney stones...
  21. pmc History, epidemiology and regional diversities of urolithiasis
    Michelle Lopez
    Department of Nephrology, Hospital de Niños JM de los Ríos, Caracas, Venezuela
    Pediatr Nephrol 25:49-59. 2010
    ..the past decades have affected the incidence and also the site and chemical composition of calculi, with calcium oxalate stones being now the most prevalent...
  22. ncbi Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation
    Lan Mo
    Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10010, USA
    Kidney Int 66:1159-66. 2004
    ..Here we examined the role of Tamm-Horsfall protein (THP), the principal urinary protein, in urinary defense against renal calcium crystal formation, using a THP knockout model that we recently developed...
  23. ncbi The efficacy of dietary intervention on urinary risk factors for stone formation in recurrent calcium oxalate stone patients
    Roswitha Siener
    Department of Urology, University of Bonn, Bonn, Germany
    J Urol 173:1601-5. 2005
    Nutrition is suggested to be the major environmental risk factor in idiopathic calcium oxalate stone disease...
  24. ncbi Effect of A. lanata leaf extract and Vediuppu chunnam on the urinary risk factors of calcium oxalate urolithiasis during experimental hyperoxaluria
    R Selvam
    Department of Medical Biochemistry, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, 600 021, India
    Pharmacol Res 43:89-93. 2001
    ..The drug increases the urine volume, thereby reducing the solubility product with respect to calcium oxalate and other crystallizing salts such as uric acid, which may induce epitaxial deposition of calcium oxalate...
  25. ncbi Prophylaxis of calcium oxalate stones by Herniaria hirsuta on experimentally induced nephrolithiasis in rats
    F Atmani
    Laboratory of Cellular Physiology and Pharmacology, Department of Biology, University Mohammed 1, Oujda, Morocco
    BJU Int 92:137-40. 2003
    ..of a herbal decoction from Herniaria hirsuta, a medicinal plant widely used in Morocco to treat kidney stones, by assessing the effect of oral administration in experimentally induced calcium oxalate (CaOx) nephrolithiasis in rats.
  26. ncbi Oxalate and calcium oxalate mediated free radical toxicity in renal epithelial cells: effect of antioxidants
    Sivagnanam Thamilselvan
    Department of Urology 2D, Vattikuti Urology Institute and Henry Ford Health Sciences Center, One Ford Place, Detroit, MI 48202, USA
    Urol Res 31:3-9. 2003
    In a previous study we demonstrated that oxalate induced free radical injury can promote calcium oxalate stone formation...
  27. ncbi Lipid peroxidation and its correlations with urinary levels of oxalate, citric acid, and osteopontin in patients with renal calcium oxalate stones
    Ho Shiang Huang
    Department of Urology, National Taiwan University Hospital, Taipei, Taiwan
    Urology 62:1123-8. 2003
    To determine whether lipid peroxidation plays a role in patients with calcium oxalate kidney stones and to determine the correlation of lipid peroxidation with tubular damage and the major urinary risk factors...
  28. ncbi Association of E-cadherin gene 3'-UTR C/T polymorphism with calcium oxalate stone disease
    Fuu Jen Tsai
    Department of Medical Genetics, China Medical College Hospital, China Medical College, Taichung, Taiwan
    Urol Int 70:278-81. 2003
    ..Our aim was to investigate a polymorphism of the CDH-1 gene 3'-UTR as a possible genetic marker in the search for the genetic causes...
  29. ncbi Decreased renal expression of the putative calcium oxalate inhibitor Tamm-Horsfall protein in the ethylene glycol rat model of calcium oxalate urolithiasis
    Susan Ruth Marengo
    Jim and Eilleen Dicke Research Laboratory, Department of Urology and Anatomy, School of Medicine, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio, USA
    J Urol 167:2192-7. 2002
    Tamm-Horsfall protein is believed to inhibit calcium oxalate crystallization, aggregation or adhesion to the renal epithelium...
  30. ncbi Urinary trefoil factor 1 is a novel potent inhibitor of calcium oxalate crystal growth and aggregation
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Urol 179:1615-9. 2008
    Crystal growth and aggregation are the important mechanisms of calcium oxalate stone formation in the kidney...
  31. ncbi Crystal retention capacity of cells in the human nephron: involvement of CD44 and its ligands hyaluronic acid and osteopontin in the transition of a crystal binding- into a nonadherent epithelium
    Anja Verhulst
    Department of Nephrology Hypertension, University of Antwerp, Antwerp, Belgium
    J Am Soc Nephrol 14:107-15. 2003
    ..The present study investigated the interaction between calcium oxalate monohydrate (COM) crystals and primary cultures of human proximal (PTC) and distal tubular/collecting duct ..
  32. ncbi Glyoxylate induces renal tubular cell injury and microstructural changes in experimental mouse
    Masahito Hirose
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya City, Aichi, 467 8601, Japan
    Urol Res 36:139-47. 2008
    ..It is suggested that calcium oxalate crystal formation requires cell injury and morphological changes of renal epithelial tubular cells induced by ..
  33. ncbi Mechanisms mediating oxalate-induced alterations in renal cell functions
    Julie A Jonassen
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Crit Rev Eukaryot Gene Expr 13:55-72. 2003
    Oxalate is a major component of the most common form of kidney stones--calcium oxalate stones...
  34. ncbi Effect of prothrombin and its activation fragments on calcium oxalate crystal growth and aggregation in undiluted human urine in vitro: relationship between protein structure and inhibitory activity
    Phulwinder K Grover
    Urology Unit, Department of Surgery, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia
    Clin Sci (Lond) 102:425-34. 2002
    ..and its activation peptides, especially the urinary form of prothrombin fragment 1, in the pathogenesis of calcium oxalate (CaOx) urolithiasis...
  35. ncbi Urinary oxalate levels and the enteric bacterium Oxalobacter formigenes in patients with calcium oxalate urolithiasis
    Cheol Kwak
    Department of Urology, Seoul National University College of Medicine and Clinical Research Institute, Seoul National University Hospital, 28 Yongon Dong, Jongno Ku, Seoul 110 744, Republic of Korea
    Eur Urol 44:475-81. 2003
    We performed a prospective study to evaluate the intestinal colonization of Oxalobacter formigenes and its relationship with urinary oxalate levels in patients with calcium oxalate stone disease.
  36. ncbi Calcium oxalate crystal adherence to hyaluronan-, osteopontin-, and CD44-expressing injured/regenerating tubular epithelial cells in rat kidneys
    Marino Asselman
    Department of Urology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    J Am Soc Nephrol 14:3155-66. 2003
    ..hyaluronan (HA) and osteopontin (OPN) and their mutual cell surface receptor CD44 play an important role in calcium oxalate (CaOx) crystal binding during wound healing...
  37. ncbi Crystal-induced inflammation of the kidneys: results from human studies, animal models, and tissue-culture studies
    Saeed R Khan
    Department of Pathology, College of Medicine, University of Florida, Gainesville, FL 32610 0275, USA
    Clin Exp Nephrol 8:75-88. 2004
    b>Calcium oxalate (CaOx), calcium phosphate (CaP), and uric acid or urate are the most common crystals seen in the kidneys...
  38. ncbi Simple classification of renal calculi closely related to their micromorphology and etiology
    Felix Grases
    Laboratory of Renal Lithiasis Research, Faculty of Sciences, University of Balearic Islands, Ctra Valldemossa km 7 5, 07071 Palma de Mallorca, Spain
    Clin Chim Acta 322:29-36. 2002
    ..Classification of renal calculi with clear correlation with the main urinary etiological conditions has been previously established. However, such information is complex and difficult to adapt to clinical routine practice...
  39. ncbi Vascular endothelial growth factor gene polymorphism is associated with calcium oxalate stone disease
    Wen Chi Chen
    Department of Urology, China Medical College Hospital, Taichung, Taiwan
    Urol Res 31:218-22. 2003
    ..We therefore investigated the association between growth factor genes and calcium oxalate stone disease...
  40. ncbi Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: osteopontin localization
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46220, USA
    Kidney Int 68:145-54. 2005
    ..Thus our purpose here is to detail the structure of the interstitial and membrane-bound plaque and explore the relationship of plaque apatite to osteopontin, a well-known crystal-associated urine protein...
  41. ncbi Presence of lipids in urine, crystals and stones: implications for the formation of kidney stones
    Saeed R Khan
    Department of Pathology, University of Florida, Gainesville, Florida 32610, USA
    Kidney Int 62:2062-72. 2002
    ..We propose that membrane lipids also promote the formation of calcium oxalate (CaOx) and calcium phosphate (CaP) containing kidney stones, and become a part of their stone matrix.
  42. ncbi Uric acid as inducer of calcium oxalate crystal development
    Felix Grases
    Laboratory of Renal Lithiasis Research, University Institute of Health Sciences Research IUNICS, University of Balearic Islands, Palma de Mallorca, Spain
    Scand J Urol Nephrol 41:26-31. 2007
    This paper deals with the mechanism by which uric acid affects calcium oxalate crystallization and the role of crystallization inhibitors in this process.
  43. pmc Superoxide from NADPH oxidase as second messenger for the expression of osteopontin and monocyte chemoattractant protein-1 in renal epithelial cells exposed to calcium oxalate crystals
    Tohru Umekawa
    Department of Urology, Kinki University School of Medicine, Osaka, Japan
    BJU Int 104:115-20. 2009
    OBJECTIVE To test the hypothesis that exposure of a renal epithelial cell line, NRK52E, to calcium oxalate monohydrate crystals (COM) would up-regulate NADPH oxidase subunit p47(phox), enhance superoxide production and increase monocyte ..
  44. ncbi Morphological conversion of calcium oxalate crystals into stones is regulated by osteopontin in mouse kidney
    Atsushi Okada
    Department of Nephrourology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya City, Aichi, Japan
    J Bone Miner Res 23:1629-37. 2008
    ..In this study, we estimated OPN function in early morphological changes of calcium oxalate crystals using OPN knockout mice: 100 mg/kg glyoxylate was intra-abdominally injected into wildtype mice (WT) ..
  45. ncbi Dietary risk factors for hyperoxaluria in calcium oxalate stone formers
    Roswitha Siener
    Department of Urology, and Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
    Kidney Int 63:1037-43. 2003
    Hyperoxaluria is a major predisposing factor in calcium oxalate urolithiasis...
  46. ncbi Dietary oxalate and calcium oxalate nephrolithiasis
    Saeed R Khan
    Department of Pathology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida 32610 0275, USA
    J Urol 178:2191-6. 2007
    Patients with calcium oxalate kidney stones are advised to decrease the consumption of foods that contain oxalate...
  47. ncbi Mechanism of calcium oxalate renal stone formation and renal tubular cell injury
    Masao Tsujihata
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Urol 15:115-20. 2008
    Formation of calcium oxalate stones tends to increase with age and begins from the attachment of a crystal formed in the cavity of renal tubules to the surface of renal tubular epithelial cells...
  48. ncbi Body size and 24-hour urine composition
    Eric N Taylor
    Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Kidney Dis 48:905-15. 2006
    ..Greater body mass index (BMI) is a risk factor for kidney stones. However, the relation between BMI and the urinary excretion of many lithogenic factors remains unclear...
  49. ncbi The role of polymer nanosurface roughness and submicron pores in improving bladder urothelial cell density and inhibiting calcium oxalate stone formation
    Young Wook Chun
    Division of Engineering, Brown University, Providence, RI 02912, USA
    Nanotechnology 20:085104. 2009
    ..to respective conventional polymers, the results provided evidence that nanorough PU and PLGA inhibited calcium oxalate stone formation; submicron pored nanorough PU inhibited calcium oxalate stone formation the most...
  50. ncbi Evaluation of sulfated polysaccharides from the brown seaweed Dictyopteris justii as antioxidant agents and as inhibitors of the formation of calcium oxalate crystals
    Karoline Rachel Teodosio Melo
    Laboratório de Biotecnologia de Polímeros Naturais Biopol, Departamento de Bioquimica, Centro de Biociencias, Universidade Federal do Rio Grande do Norte UFRN, Natal, Rio Grande do Norte 59072 970, Brazil
    Molecules 18:14543-63. 2013
    ..antioxidant activity under different conditions in some of the in vitro tests and inhibited the formation of calcium oxalate crystals. Fucan DJ-0...
  51. ncbi Therapeutic action of citrate in urolithiasis explained by chemical speciation: increase in pH is the determinant factor
    Allen Rodgers
    Department of Chemistry, University of Cape Town, Rondebosch, South Africa 7701
    Nephrol Dial Transplant 21:361-9. 2006
    The therapeutic action of citrate in the management of calcium oxalate urolithiasis has been attributed to the depletion of free calcium ions by complexation of the latter by citrate itself...
  52. ncbi Association of the vitamin D receptor gene start codon Fok I polymorphism with calcium oxalate stone disease
    W C Chen
    Department of Urology, China Medical College Hospital, School of Medicine, China Medical College, Taichung, Taiwan
    BJU Int 87:168-71. 2001
    ..To assess the use of Fok I polymorphism (the most frequent polymorphism, at the start codon of the vitamin D receptor gene, VDR) as a convenient genetic marker in identifying the cause of urolithiasis...
  53. ncbi Adhesion, internalization and metabolism of calcium oxalate monohydrate crystals by renal epithelial cells
    J C Lieske
    Department of Medicine, University of Chicago, Illinois, USA
    Kidney Int 52:1291-301. 1997
    ..cells in monolayer culture (BSC-1 line), used to model the tubule, rapidly bound and internalized crystals of calcium oxalate monohydrate (COM), the most common constituent of renal stones...
  54. ncbi Evidence that calgranulin is produced by kidney cells and is an inhibitor of calcium oxalate crystallization
    S N Pillay
    Department of Medicine, Section of Nephrology, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol 275:F255-61. 1998
    Urine produced by normal human kidneys is almost always supersaturated with respect to calcium oxalate (CaOx), the most common constituent of human kidney stones...
  55. pmc The infection processes of Sclerotinia sclerotiorum in cotyledon tissue of a resistant and a susceptible genotype of Brassica napus
    Harsh Garg
    School of Plant Biology, Faculty of Natural and Agricultural Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Ann Bot 106:897-908. 2010
    ..Sclerotinia sclerotiorum can attack >400 plant species worldwide. Very few studies have investigated host-pathogen interactions at the plant surface and cellular level in resistant genotypes of oilseed rape/canola (Brassica napus)...
  56. ncbi Mitochondrial permeability transition pore opening induces the initial process of renal calcium crystallization
    Kazuhiro Niimi
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Free Radic Biol Med 52:1207-17. 2012
    ..In the in vitro study, cultured renal tubular cells were exposed to calcium oxalate monohydrate (COM) crystals and treated with CsA (2 μM)...
  57. ncbi Effect of biomolecules from human renal matrix of calcium oxalate monohydrate (CaOx) stones on in vitro calcium phosphate crystallization
    Priyadarshini Pathak
    Jaypee University of Information Technology, Waknaghat, India
    Int Braz J Urol 36:621-8. 2010
    Investigate the activity of high and low molecular weight biomolecules present in the matrix of human calcium oxalate (CaOx) stones not only on the initial mineral phase formation of calcium and phosphate (CaP) but also on its growth and ..
  58. ncbi Role of sex hormones in experimental calcium oxalate nephrolithiasis
    J Fan
    Urolithiasis Research Laboratory, Division of Urology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Am Soc Nephrol 10:S376-80. 1999
    It is unclear why men have a higher incidence of calcium oxalate nephrolithiasis than women. This study examined the role of sex hormones on urinary oxalate excretion and kidney stone formation in an experimental model of urolithiasis...
  59. ncbi Inhibition of calcium oxalate crystal growth and aggregation by prothrombin and its fragments in vitro: relationship between protein structure and inhibitory activity
    P K Grover
    Urology Unit, Department of Surgery, Flinders Medical Centre, Flinders University of South Australia
    Eur J Biochem 263:50-6. 1999
    ..One of these fragments, F1, is excreted in human urine and is the principal protein occluded into calcium oxalate (CaOx) crystals precipitated from it...
  60. ncbi Citrate modulates calcium oxalate crystal growth by face-specific interactions
    Bernd Grohe
    School of Dentistry, University of Western Ontario, London, Ont, Canada
    Cells Tissues Organs 194:176-81. 2011
    Because of its ability to inhibit the growth of calcium oxalate monohydrate (COM) crystals, citrate plays an important role in preventing the formation of kidney stones...
  61. ncbi The role of Oxalobacter formigenes colonization in calcium oxalate stone disease
    Roswitha Siener
    University Stone Centre, Department of Urology, University of Bonn, Bonn, Germany
    Kidney Int 83:1144-9. 2013
    ..Of 37 calcium oxalate stone formers, 26 tested negative for O...
  62. pmc Morphologies and elemental compositions of calcium crystals in phyllodes and branchlets of Acacia robeorum (Leguminosae: Mimosoideae)
    Honghua He
    School of Plant Biology, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Ann Bot 109:887-96. 2012
    Formation of calcium oxalate crystals is common in the plant kingdom, but biogenic formation of calcium sulfate crystals in plants is rare...
  63. pmc p38 MAPK mediates calcium oxalate crystal-induced tight junction disruption in distal renal tubular epithelial cells
    Paleerath Peerapen
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Sci Rep 3:1041. 2013
    We examined whether p38 MAPK plays role in calcium oxalate monohydrate (COM) crystal-induced tight junction disruption...
  64. ncbi Intestinal oxalate absorption is higher in idiopathic calcium oxalate stone formers than in healthy controls: measurements with the [(13)C2]oxalate absorption test
    Susanne Voss
    Department of Urology Division of Experimental Urology, University of Bonn, Bonn, Germany
    J Urol 175:1711-5. 2006
    We assessed the importance of oxalate hyperabsorption for idiopathic calcium oxalate urolithiasis, oxalate absorption in healthy volunteers and recurrent calcium oxalate stone formers was compared.
  65. pmc Antioxidant properties of polysaccharide from the brown seaweed Sargassum graminifolium (Turn.), and its effects on calcium oxalate crystallization
    Chao Yan Zhang
    Shanghai Key Laboratory of Functional Materials Chemistry, Research Center of Analysis and Testing, East China University of Science and Technology, Shanghai 200237, China
    Mar Drugs 10:119-30. 2012
    We investigated the effects of polysaccharides from the brown seaweed Sargassum graminifolium (Turn.) (SGP) on calcium oxalate crystallization, and determined its antioxidant activities...
  66. ncbi Serial crystalluria determination and the risk of recurrence in calcium stone formers
    Michel Daudon
    Department of Biochemistry A, Necker Hosptial, Paris, France
    Kidney Int 67:1934-43. 2005
    ..Urinary crystal precipitation is the necessary initial step in kidney stone formation. However, clinical relevance of crystalluria in the evaluation of stone formers is disputed...
  67. ncbi Serum testosterone may be associated with calcium oxalate urolithogenesis
    Justin M Watson
    Department of Urology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Endourol 24:1183-7. 2010
    ..Specifically, castration has been shown to decrease stone formation in rat models. The association between testosterone and stone formation in humans, however, has not been well investigated...
  68. ncbi Renal cell osteopontin production is stimulated by calcium oxalate monohydrate crystals
    J C Lieske
    Department of Medicine, University of Chicago, Illinois, USA
    Kidney Int 51:679-86. 1997
    ..human osteopontin (OPN), block adhesion to renal tubular cells of the most common crystal in kidney stones, calcium oxalate monohydrate (COM)...
  69. ncbi Calcium stone disease: a multiform reality
    Alberto Trinchieri
    Urology Unit, Lecco Hospital, Lecco, Italy
    Urol Res 33:194-8. 2005
    In calcium renal stones, calcium oxalate and calcium phosphate in various crystal forms and states of hydration can be identified...
  70. ncbi Infrared spectroscopic analysis of 5,248 urinary stones from Chinese patients presenting with the first stone episode
    Xizhao Sun
    Department of Urology, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008 Jiangsu, China
    Urol Res 39:339-43. 2011
    ..The overall sex ratio (male:female) was 2.34:1. Results showed that the preponderant type of stone was calcium oxalate, followed by carbapatite, anhydrous uric acid, struvite and cystine...
  71. ncbi Effects of a low-salt diet on idiopathic hypercalciuria in calcium-oxalate stone formers: a 3-mo randomized controlled trial
    Antonio Nouvenne
    Department of Clinical Sciences, University of Parma, Parma, Italy
    Am J Clin Nutr 91:565-70. 2010
    ....
  72. ncbi Study of a rat model for calcium oxalate crystal formation without severe renal damage in selected conditions
    Satoshi Yamaguchi
    Department of Medicine, Medical College of Wisconsin and the Department of Veterans Affairs Medical Center, Milwaukee, Wisconsin, USA
    Int J Urol 12:290-8. 2005
    ..in high doses, ethylene glycol (EG) has been used with ammonium chloride (NH(4)Cl) or vitamin D(3) to study calcium oxalate stone formation in rat models...
  73. ncbi An oxalate-binding protein with crystal growth promoter activity from human kidney stone matrix
    A Govindaraj
    Department of Medical Biochemistry, Dr A L M PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, India
    BJU Int 90:336-44. 2002
    To fractionate renal-stone matrix proteins, identify the presence of oxalate-binding protein and assess its effect in a calcium oxalate (CaOx) crystal growth system.
  74. ncbi Calcium oxalate crystals in fetal bovine serum: implications for cell culture, phagocytosis and biomineralization studies in vitro
    Claudio E Pedraza
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada H3A 2B2
    J Cell Biochem 103:1379-93. 2008
    ..we report that commercially available FBS from different major suppliers consistently contain precipitated, calcium oxalate crystals-either in the monohydrate (COM) or dihydrate (COD) form...
  75. ncbi Glycosylation of prothrombin fragment 1 governs calcium oxalate crystal nucleation and aggregation, but not crystal growth
    Dawn Webber
    Department of Chemistry, University of Cape Town, Private Bag, Rondebosch, Cape Town, 7701, South Africa
    Urol Res 35:277-85. 2007
    Urinary glycoproteins play an important role in the modulation of calcium oxalate crystallisation...
  76. ncbi Inhibition of growth and aggregation of calcium oxalate crystals in vitro--a comparison of four human proteins
    P K Grover
    Department of Surgery, Flinders Medical Centre, Adelaide, South Australia, Australia
    Eur J Biochem 253:637-44. 1998
    ..glycoprotein (THG), human serum albumin (HSA), alpha1-microglobulin and prothrombin fragment 1 (PTF1) on calcium oxalate crystallization...
  77. ncbi Fibronectin inhibits endocytosis of calcium oxalate crystals by renal tubular cells
    Masao Tsujihata
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 13:743-6. 2006
    ..reported that FN has a protective effect against injury of renal tubular cells by exposure to oxalate and calcium oxalate (CaOX) crystals and inhibits the adhesion of CaOX crystals to renal tubular cells...
  78. ncbi Morphology, particle size distribution, aggregation, and crystal phase of nanocrystallites in the urine of healthy persons and lithogenic patients
    Jie Yu He
    Institute of Biomineralization and Lithiasis Research and the Department of Chemistry, Jinan University, Guangzhou 510632, China
    IEEE Trans Nanobioscience 9:156-63. 2010
    ..The formed nuclei then grow or/and aggregate to a pathological size. Thus, the nanocrystallites in urine may be related to the formation of urinary stones...
  79. ncbi Urine protein markers distinguish stone-forming from non-stone-forming relatives of calcium stone formers
    Kristin J Bergsland
    Litholink Corp, 2250 W Campbell Park Dr, Chicago, IL 60612, USA
    Am J Physiol Renal Physiol 291:F530-6. 2006
    We have investigated urine protein inhibitors of calcium oxalate crystallization to determine whether variations in these proteins are associated with kidney stone disease and whether protein measurements improve the identification of ..
  80. ncbi Reduced crystallization inhibition by urine from women with nephrolithiasis
    John R Asplin
    Renal Section, University of Chicago, and Litholink Corporation, Chicago, Illinois 60637, USA
    Kidney Int 61:1821-9. 2002
    Human urine is known to inhibit growth, aggregation, nucleation, and cell adhesion of calcium oxalate monohydrate (COM) crystals, the main solid phase of human kidney stones...
  81. pmc Physiopathology and etiology of stone formation in the kidney and the urinary tract
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Ms 5055, Indianapolis, IN 46220, USA
    Pediatr Nephrol 25:831-41. 2010
    ..of a renal papilla at sites of interstitial apatite plaque (termed Randall's plaque), as seen in idiopathic calcium oxalate stone formers; (2) stones attached to plugs protruding from the openings of ducts of Bellini, as seen in ..
  82. ncbi Effects of an aqueous extract from Phyllantus niruri on calcium oxalate crystallization in vitro
    M E Barros
    Nephrology Division, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Urol Res 30:374-9. 2003
    ..no toxicity, potentially increases calculus voiding by stone forming patients and inhibits the endocytosis of calcium oxalate (CaOx) crystals by MDCK cells. In addition, in a rat model of urolithiasis it reduced calculus growth...
  83. ncbi Effect of Aerva lanata on calcium oxalate urolithiasis in rats
    P Soundararajan
    Department of Siddha Medicine, Faculty of Science, Tamil University, Thanjavur 613 005, India
    Indian J Exp Biol 44:981-6. 2006
    b>Calcium oxalate (CaOx) stone was induced in rats using 0.75% of ethylene glycol in drinking water for 28 days...
  84. ncbi Antiurolithic effect of Bergenia ligulata rhizome: an explanation of the underlying mechanisms
    Samra Bashir
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 122:106-16. 2009
    ..Bergenia ligulata is widely used plant in South Asia, mainly India and Pakistan, as a traditional medicine for treatment of urolithiasis...
  85. ncbi Supplementation of vitamin E and selenium prevents hyperoxaluria in experimental urolithic rats
    Mani Santhosh Kumar
    Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
    J Nutr Biochem 14:306-13. 2003
    Renal injury is considered as one of the prerequisites for calcium oxalate retention...
  86. ncbi Dietary therapy in idiopathic nephrolithiasis
    Loris Borghi
    Dipartimento di Scienze Cliniche, Universita di Parma, Italy
    Nutr Rev 64:301-12. 2006
    ..The final part of the paper will provide practical guidelines for pursuing an anti-lithogenic diet in idiopathic calcium and uric acid stones...
  87. ncbi Preventive effects of green tea on renal stone formation and the role of oxidative stress in nephrolithiasis
    Yasunori Itoh
    Department of Surgical Medicine, Nephro Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya City, Aichi 467 8601, Japan
    J Urol 173:271-5. 2005
    ..Green tea leaves contain approximately 13% catechins, which have been shown to have antioxidant effects. We investigated the inhibitory, antioxidative effects of green tea on calcium urinary stone formation...
  88. ncbi Control of calcium oxalate crystal growth by face-specific adsorption of an osteopontin phosphopeptide
    Bernd Grohe
    CIHR Group in Skeletal Development and Remodeling, School of Dentistry, University of Western Ontario, London, Canada
    J Am Chem Soc 129:14946-51. 2007
    ..of control, we are studying the interaction between the phosphoprotein osteopontin (OPN) and the biomineral calcium oxalate monohydrate (COM)...
  89. pmc Oxalobacter formigenes may reduce the risk of calcium oxalate kidney stones
    David W Kaufman
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    J Am Soc Nephrol 19:1197-203. 2008
    Most kidney stones are composed primarily of calcium oxalate. Oxalobacter formigenes is a Gram-negative, anaerobic bacterium that metabolizes oxalate in the intestinal tract and is present in a large proportion of the normal adult ..
  90. ncbi Identification of myeloperoxidase, alpha-defensin and calgranulin in calcium oxalate renal stones
    Shamim Mushtaq
    Department of Biological and Biomedical Sciences, Research Laboratory, Juma Building, Pakistan
    Clin Chim Acta 384:41-7. 2007
    ..We characterized proteins from the inner core and outer matrix of calcium oxalate (CaOx) renal stones.
  91. ncbi Predictive value of kidney stone composition in the detection of metabolic abnormalities
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Am J Med 115:26-32. 2003
    ..To determine if kidney stone composition can predict the underlying medical diagnosis, and vice versa...
  92. ncbi The effect of Phyllanthus niruri on urinary inhibitors of calcium oxalate crystallization and other factors associated with renal stone formation
    A M Freitas
    Nephrology Division, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil
    BJU Int 89:829-34. 2002
    ..To evaluate the effect of an aqueous extract of Phyllanthus niruri (Pn), a plant used in folk medicine to treat lithiasis, on the urinary excretion of endogenous inhibitors of lithogenesis, citrate, magnesium and glycosaminoglycans (GAGs)...
  93. ncbi Hyperoxaluria-induced oxidative stress and antioxidants for renal protection
    Saeed R Khan
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida 32610, USA
    Urol Res 33:349-57. 2005
    ....
  94. ncbi Effects of urine dilution on quantity, size and aggregation of calcium oxalate crystals induced in vitro by an oxalate load
    Angela Guerra
    Department of Clinical Sciences, University of Parma, Parma, Italy
    Clin Chem Lab Med 43:585-9. 2005
    ..This study aimed at assessing how urine dilution affects urinary calcium oxalate crystallization...
  95. ncbi Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both
    Lan Mo
    Dept of Urology, New York Univ School of Medicine, Veterans Affairs Medical Center in Manhattan, 423 E23 St, Rm 18064S, New York, NY 10010, USA
    Am J Physiol Renal Physiol 293:F1935-43. 2007
    Although often supersaturated with mineral salts such as calcium phosphate and calcium oxalate, normal urine possesses an innate ability to keep them from forming harmful crystals...
  96. ncbi Heavy metal stress reduces the deposition of calcium oxalate crystals in leaves of Phaseolus vulgaris
    David Jáuregui-Zúñiga
    Departamento de Bioquimica, Instituto de Quimica, UNAM, Circuito Exterior, CU Mexico
    J Plant Physiol 162:1183-7. 2005
    b>Calcium oxalate (CaOx) crystals in plants may serve as a sink for the absorption of excess calcium, and they could play an important role in heavy metal detoxification...
  97. ncbi Probiotics and dietary manipulations in calcium oxalate nephrolithiasis: two sides of the same coin?
    Loris Borghi
    Department of Clinical Sciences, University of Parma, Parma, Italy
    Kidney Int 78:1063-5. 2010
    ..However, the discrepancy between in vitro and in vivo results requires further studies to identify the right patient target, the correct dosage, and the real modification of natural and clinical history of nephrolithiasis...
  98. ncbi Effect of dietary water intake on urinary output, specific gravity and relative supersaturation for calcium oxalate and struvite in the cat
    Catherine M F Buckley
    Waltham Centre for Pet Nutrition, Freeby Lane, Waltham on the Wolds, Melton Mowbray, Leicestershire LE14 4RT, UK
    Br J Nutr 106:S128-30. 2011
    ..urine volume, water drunk and total fluid intake were measured daily; relative supersaturation (RSS) for calcium oxalate (CaOx) and struvite was calculated using the SUPERSAT computer program. Cats fed the 73...
  99. pmc Phenotypic and functional analysis of human SLC26A6 variants in patients with familial hyperoxaluria and calcium oxalate nephrolithiasis
    Carla G Monico
    Mayo Clinic Hyperoxaluria Center, Division of Nephrology and Hypertension, Departments of Internal Medicine and Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Kidney Dis 52:1096-103. 2008
    Urinary oxalate is a major risk factor for calcium oxalate stones. Marked hyperoxaluria arises from mutations in 2 separate loci, AGXT and GRHPR, the causes of primary hyperoxaluria (PH) types 1 (PH1) and 2 (PH2), respectively...
  100. ncbi Citric acid or citrates in urine: which should we focus on in the prevention of calcium oxalate crystals and stones?
    Norbert Laube
    Division of Experimental Urology, Department of Urology, Bonn University, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Urol Res 30:336-41. 2002
    ..58 calcium stone formers, were investigated for pH, citric acid concentration ([CA]), and related relative calcium oxalate supersaturation (RS)...
  101. ncbi Altered proteins in MDCK renal tubular cells in response to calcium oxalate dihydrate crystal adhesion: a proteomics approach
    Theptida Semangoen
    Medical Proteomics Unit and Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 7:2889-96. 2008
    ..kidney (MDCK) cells, which were derived from dog kidney and exhibited distal renal tubule phenotype, during calcium oxalate dihydrate (COD) crystal adhesion...

Research Grants65

  1. INTER ALPHA TRYPSIN INHIBITOR IN CAOX UROLITHIASIS
    Susan Ruth Marengo; Fiscal Year: 2002
    ..blot analysis of spot and 24 hr urine specimens, we have demonstrated that males who are confirmed active calcium oxalate (CaOx) stone formers (SF) typically expressed inter-alpha-trypsin inhibitor-trimer (IaTI-trimer) whereas age ..
  2. Probiotic-Induced Elimination of Oxalate to treat Hyperoxaluria
    Marguerite Hatch; Fiscal Year: 2013
    ..to a deficiency of the liver enzyme alanine-glyoxylate aminotransferase (AGT), results in hyperoxaluria and calcium oxalate kidney stone formation in addition to tissue deposition of oxalate (oxalosis), renal failure and death unless ..
  3. The Effect of Gastric Bypass Surgery on Renal Function and Metabolism
    Benjamin K Canales; Fiscal Year: 2013
    ..glomerular, interstitial, and papillary cells are chronically exposed to high amounts of oxalate and/or calcium oxalate crystals, leading to the production of reactive oxygen species, oxidative stress, renal injury, and ..
  4. Crystal Associated Renal Inflammation and Treatment Options
    Saeed R Khan; Fiscal Year: 2012
    Crystals of calcium oxalate (CaOx), are major constituents of most urinary stones. They are also seen deposited in the kidneys of patients with primary or enteric hyperoxaluria...
  5. Identification of a Multi-Analyte Profile for Primary Hyperoxaluria
    James P Mapes; Fiscal Year: 2012
    ..in the AGXT gene leads to overproduction of oxalate by the liver, resulting in widespread deposition of calcium oxalate in the kidneys and other organs. Unfortunately, PH1 disease progression is not understood...
  6. EPITHELIAL OXALATE AND CITRATE TRANSPORT
    DAVID BRUCE MOUNT; Fiscal Year: 2011
    ..This phenotypic characterization will be correlated with the impact of these polymorphisms on the genetic predisposition to stone disease and hyperoxaluria, as determined in Project 3. ..
  7. Endogenous Oxalate Synthesis
    Ross P Holmes; Fiscal Year: 2013
    DESCRIPTION: Endogenous oxalate synthesis plays an important role in idiopathic calcium oxalate stone disease and primary hyperoxaluria. The pathways that underlie this synthesis are poorly understood despite decades of research...
  8. Biochemical Studies of Oxalate Decarboxylase
    NIGEL GORDON RICHARDS; Fiscal Year: 2013
    ..and so OxDC has the potential for clinical use in treating urolithiasis and/or preventing the formation of calcium oxalate-based stones...
  9. Oxalate handling and Oxalobacter formigenes colonization in a mouse model
    John Knight; Fiscal Year: 2013
    ..Kidney stones that contain more than 50% calcium oxalate account for approximately 75% of all kidney stone cases...
  10. Drosophila model of oxalate nephrolithiasis
    Michael F Romero; Fiscal Year: 2013
    ..b>Calcium oxalate (CaOx) stones are the most common (~70%)...
  11. ROLE OF TAMM-HORSFALL PROTEIN IN URINARY TRACT DEFENSE
    Xue ru Wu; Fiscal Year: 2013
    ..of bona-fide kidney stones in THP KO mice relies on urinary super saturation of calcium phosphate or calcium oxalate by generating compound, genetically engineered mice that naturally develop these conditions...
  12. An In Vitro Model for Studying the Role of Acidic Proteins in Randalls Plaque and
    Saeed R Khan; Fiscal Year: 2013
    ..phosphate (CaP) in the form of Randall's plaque (RP), and 2) the subsequent overgrowth of RP with calcium oxalate (CaOx), forming a composite stone...
  13. Urolithiasis: Oxalate Interactions with the Renal Cells
    Hari K Koul; Fiscal Year: 2011
    ..Thus this proposed study completely satisfies the requirements set forth in the Program Announcement. ..
  14. Dietary Oxalate and Kidney Stone Formation
    DEAN GEORGE ASSIMOS; Fiscal Year: 2010
    ..The bulk of these stones consist primarily of calcium oxalate. The amount of calcium and oxalate in urine are thus significant risk factors for the disease...
  15. Oxalate Reduction by Oral Administration of Oxalate Degrading Enzymes
    Qingshan Li; Fiscal Year: 2010
    ..High concentrations of oxalate and deposition of calcium oxalate (CaOx) crystals in the kidneys can evoke an inflammatory response and induce tubulointerstitial damage ..
  16. Influence of Urinary Macromolecules on Crystal Aggregation
    Jeffrey A Wesson; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Most kidney stones form as aggregates of calcium oxalate monohydrate (COM) crystals under the influence of urinary macromolecules, but currently, no urine test can prospectively identify stone ..
  17. Reduction of Dietary Oxalate
    Qingshan Li; Fiscal Year: 2013
    ..Of all stones developed approximately 75% are composed of calcium oxalate. Urinary oxalate is regarded as a driving force for calcium oxalate stone formation, and absorption of ..
  18. Roles of SLC26A6 in Renal NaCI Transport and Prevention of Oxalate Urolithiasis
    Peter S Aronson; Fiscal Year: 2013
    ..latter process is critical to limiting net intestinal absorption of oxalate and preventing hyperoxaluria and calcium oxalate urolithiasis...
  19. CRYSTAL INTERACTIONS IN RENAL STONE DISEASE
    Neil S Mandel; Fiscal Year: 2010
    ..Idiopathic calcium oxalate stone disease accounts for the majority of stone forming patients...
  20. COATING OF URINARY PROTHESES TO PREVENT ENCRUSTATION
    Harmeet Sidhu; Fiscal Year: 2000
    ..to the biomaterial and form biofilms, a process dependent on the deposition of urinary components (especially calcium oxalate, calcium apatite and struvite) onto the biomaterial...
  21. Reduction of Dietary Oxalate
    Qingshan Li; Fiscal Year: 2010
    ..Of all stones developed approximately 70% are composed of calcium oxalate. Urinary oxalate is regarded as a driving force for calcium oxalate stone formation, and absorption of ..
  22. Mechanisms of Oxalobacter-Induced Enteric Oxalate Excretion
    Marguerite Hatch; Fiscal Year: 2010
    Hyperoxaluria is considered to be a major risk factor in calcium oxalate stone disease which occurs in about 12% of the American population and, apart from reducing dietary sources of oxalate, there is currently no pharmacological ..
  23. REGULATION OF ENTERIC HYPEROXALURI BY OXALOBACTER
    AMMON PECK; Fiscal Year: 2001
    ..it can cause numerous pathological conditions, including hyperoxaluria, cardiac conductance disorders, calcium oxalate stones, renal failure, death and possibly inflammatory bowel disease and vulvovestibulitis...
  24. Hyperoxaluria Leading to Tubule Injury and Kidney Stone Disease
    Neil Mandel; Fiscal Year: 2004
    ..We propose that the pig is ideal for the development of an animal model of calcium oxalate crystalluria and calcium oxalate stone disease...
  25. Treatment of Calcium Nephrolithiasis Sodium Thiosulfate
    John Asplin; Fiscal Year: 2006
    ..The aims of this proposal are to determine if sodium thiosulfate can reduce calcium oxalate and calcium phosphate stone formation and/or reduce urine crystallization potential in hypercalciuric kidney ..
  26. ENZYMES IN ANIMAL METABOLISM OF OXALATE DERIVATIVES
    Gordon Hamilton; Fiscal Year: 1990
    ..in animals, it may aid in our understanding of the reasons for the development of kidney stones due to calcium oxalate. Finally, if oxalyl derivatives are found to be intermediates in ascorbate catabolism, it will clarify ..
  27. Oxalobacter as a therapy in IBD-associated urolithiasis
    AMMON PECK; Fiscal Year: 2006
    ..the gut has been shown to correlate with hyperoxaluria and an increased frequency of first-time and recurrent calcium oxalate kidney stones; consequently, the absence of O. formigenes appears to be a risk factor for urolithiasis...
  28. Diagnosis of Crystalopathies via Raman Spectroscopy
    Ozan Akkus; Fiscal Year: 2006
    ..urate, calcium pyrophosphate dihydrate, hydroxyapatite, octacalcium phosphate, tricalcium phosphate, calcium oxalate, cholesterol, cystine and xanthine will be mixed with healthy synovial fluid samples at various ..
  29. CALCIUM OXALATE IN BIOLOGICAL SYSTEMS
    ROSS HOLMES; Fiscal Year: 1999
    ..Such scientists will include plant biologists who investigate the orderly formation of calcium oxalate crystals of precise shape in specialized plant cells, microbiologists who examine the ability of ..
  30. ENZYME-COATED URINARY PROSTHESES TO PREVENT ENCRUSTATION
    STEPHEN BARTELMEZ; Fiscal Year: 2004
    ....
  31. Genetic Linkages in Calcium Oxalate Stone Disease
    Neil Mandel; Fiscal Year: 2007
    ..To date, the only well-defined genetic abnormalities leading to hyperoxaluria and calcium oxalate stone disease have been described for primary and secondary hyperoxaluria and associated with specific enzyme ..
  32. GPHRP KNOCKOUT MOUSE AS A MODEL OF HYPEROXALURIA
    Scott Cramer; Fiscal Year: 2003
    ..Overproduction of oxalate can lead to calcium oxalate stone disease, nephrocalcinosis, end-stage renal failure, and systemic oxalosis...
  33. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2010
    Hyperoxaluria is considered a major risk factor in the genesis of calcium oxalate stone disease which occurs in about 12% of the U. S. population costing an estimated $2 billion annually...
  34. DIGESTION OF FOOD OXALATE
    Harmeet Sidhu; Fiscal Year: 2000
    ..to the amount of oxalate excreted in urine and thus plays an important role in the development of calcium oxalate kidney stones...
  35. Mitochondrial GRHPR and Hyperoxaluria
    Scott Cramer; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): This R21 proposal, which is responsive to PA-03-065 "Calcium oxalate Stone Diseases", builds on our recent demonstration of the presence of glyoxylate reductase/hydroxypyruvate reductase ..
  36. ENTERIC ELIMINATION OF OXALIC ACID
    Marguerite Hatch; Fiscal Year: 1999
    ..The most common stone is comprised of calcium oxalate (about 80%) and a major risk factor is elevated urinary oxalate concentration...
  37. OXALOBACTER FORMIGENES DIAGNOSTIC KIT DEVELOPMENT
    Robert Harris; Fiscal Year: 2003
    ..of Oxalobacter formigenes (Oxf) from the GI-tract is a risk factor for development of hyperoxaluria and calcium oxalate kidney stones...
  38. Predicting Relapse During Treatment for Nephrolithiasis
    KRISTIN BERGSLAND; Fiscal Year: 2004
    ..We have found two proteins that are known inhibitors of calcium oxalate crystal growth to be significantly altered in the urine of stone formers...
  39. Urine Crystal Inhibition in Pediatric Nephrolithiasis
    KRISTIN BERGSLAND; Fiscal Year: 2007
    ..We have found three proteins that are known inhibitors of calcium oxalate crystal growth to be significantly altered in the urine of adult stone formers...
  40. CRYSTAL GROWTH INHIBITOR PROTEIN & NEPHROLITHIASIS
    Elaine Worcester; Fiscal Year: 1993
    ..that has been isolated from human urine and human kidney tissue culture, and that inhibits growth of the calcium oxalate crystals in vitro...
  41. Structure and Enzyme Function in Glyoxylate Metabolism and Hyperoxaluria
    W Lowther; Fiscal Year: 2007
    ..These mutations ultimately result in the buildup of oxalate and the formation and deposition of urinary tract calcium oxalate kidney stones...
  42. UROLITHIASIS--ROLE OF NEPHRON DYSFUNCTION/INJURY
    Julie Jonassen; Fiscal Year: 2003
    ..is that oxalate-induced injury to renal epithelial cells plays a central role in the development of calcium oxalate stone disease, with oxalate-induced injury promoting the nucleation, growth and retention of calcium oxalate ..
  43. PROTEIN INHIBITORS OF CALCIUM PHOSPHATE PRECIPITATION
    David Schlesinger; Fiscal Year: 1980
    ..Finally in collaboration with Frederic Coe, at Michael Reese Hospital in Chicago, we are beginning to study the structure of an inhibitor of calcium oxalate precipitation in human urine.
  44. URINARY MACROMOLECULES AND RENAL LITHIASIS
    Martin Resnick; Fiscal Year: 1980
    ..Twenty-four hour urine specimens are collected for metabolic active non-infectious calcium oxalate/calcium phosphate stone forming patients and non-stone forming population...
  45. LIPIDS AND UROLITHIASIS
    Saeed Khan; Fiscal Year: 1999
    ..Seventy to eighty percent of the stones contain calcium oxalate (CaOx)...
  46. Urine Protein Predictors of Nephrolithiasis
    KRISTIN BERGSLAND; Fiscal Year: 2005
    ..We have found three proteins that are known inhibitors of calcium oxalate crystal growth to be significantly altered in the urine of stone formers...
  47. Development of a new treatment of urinary stone disease
    Paul Voziyan; Fiscal Year: 2002
    ..Since a majority of urinary stones are made of calcium oxalate, the level of urinary oxalate is one of the major risk factors of stone formation...
  48. CaP, crystal responsible for idiopathic nephrolithasis
    Saeed Khan; Fiscal Year: 2008
    ..Type density and size must conform to limits and specifications provided in the PHS 398Instructions. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  49. TISSUE-CRYSTAL INTERACTION CA OXALATE NEPHROLITHIASIS
    Saeed Khan; Fiscal Year: 2003
    ..39 billion dollars/year. Nearly two-thirds of the urinary stones contain calcium oxalate. Chances of stone recurrence within 10 years of the first episode are over 60 percent...
  50. 2ND FINLAYSON COLLOQUIUM ON UROLITHIASIS
    Saeed Khan; Fiscal Year: 1999
    ..adapted from the application) A research meeting entitled 2nd Finlayson Colloquium on Urolithiasis: Calcium Oxalate Nephrolithiasis will be held on January 29-31, 1999, at the University of Florida, in Gainesville, Florida...
  51. Risk for Renal Injury Caused by Shock Wave Lithotripsy
    Andrew Evan; Fiscal Year: 2008
    ..All of these proposed studies aim at understanding the adverse effects of shock waves and advancing the safety of all stone patients at a time when reports of adverse effects in SWL are on the rise. ..
  52. GORDON CONFERENCE--CALCIUM OXALATE
    LYNWOOD SMITH; Fiscal Year: 1991
    The ion, oxalate, and its salt, calcium oxalate, are of special interest to scientists who study bacteria, fungi, plants, animals, and humans...
  53. IKSI: 2nd International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2008
    ..This assumption was supported by the great success of the 1st International Urolithiasis Research symposium and the high level of interest in the 2nd symposium date. [unreadable] [unreadable] [unreadable]..
  54. TEM with Digital and Cryopreparation Systems
    Andrew Evan; Fiscal Year: 2003
    ..Dr. Richard Gregory will employ immunohistochemistry to examine the role of a Streptococcus mutans 65 kDa fimbrial protein binding as a mechanism for the induction of dental carries. ..
  55. IKSI: 1st Annual International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  56. CLC-5 Inactivation and Hypercalciuria in Dent's Disease
    STEVEN SCHEINMAN; Fiscal Year: 2004
    Hypercalciuria is the most common risk factor for calcium oxalate stone disease and often has an hereditary component...
  57. OXALATE SYNTHESIS IN HEP G2 CELLS
    ROSS HOLMES; Fiscal Year: 2000
    ..synthesis of oxalate makes an important contribution to the urinary excretion of oxalate and the formation of calcium oxalate kidney stones...
  58. A Novel Predictor of Nephrolithiasis
    KRISTIN BERGSLAND; Fiscal Year: 2003
    ..western blotting and ELISA methods to measure various forms of a urine protein that is a known inhibitor of calcium oxalate crystallization...
  59. EFFECTS OF ACID ON BONE
    David A Bushinsky; Fiscal Year: 2010
    ..The current proposal is aimed at understanding the first steps by which acid is detected by bone cells. Understanding the process by which the bone detects and neutralizes the acid can lead to an improvement in bone health. ..
  60. DIET SALT, CALCIUM KIDNEY STONES, BONE IN STONE FORMERS
    Linda Massey; Fiscal Year: 2001
    ..Thirty-two subjects with a history of at least one calcium oxalate kidney stone will be recruited; 16 with hypercalciuria, 16 normocalciuria...
  61. Novel Risk Factors for Kidney Stone Formation
    Eric Taylor; Fiscal Year: 2008
    ..At the completion of this career development award, Dr. Taylor will have a unique combination of skills and experience that will enable him to succeed as an independent clinical investigator. ..
  62. PROTEIN-MINERAL INTERACTIONS AND CALCIUM OXALATE STONES
    ROSEMARY RYALL; Fiscal Year: 2008
    ..The role of urinary proteins in calcium oxalate (CaOx) kidney stone formation, particularly intracrystalline proteins, remains a mystery...
  63. Structural identification of a compound preventing calcium oxalate stone disease
    JEREMIAH COSTELLO; Fiscal Year: 2008
    ..and identify the chemical and structural composition of a plant compound effective in treating and preventing calcium oxalate kidney stone disease in animal studies...
  64. NOVEL INHIBITOR OF CRYSTAL ADHESION TO RENAL CELLS
    JOHN LIESKE; Fiscal Year: 2004
    ..My studies during the past 8 years demonstrate that calcium oxalate monohydrate (COM) crystals bind within seconds to anionic, sialic acid- containing glycoproteins on the ..