calcium oxalate

Summary

Summary: The calcium salt of oxalic acid, occurring in the urine as crystals and in certain calculi.

Top Publications

  1. ncbi The effect of different diets on urine composition and the risk of calcium oxalate crystallisation in healthy subjects
    Roswitha Siener
    Division of Experimental Urology, Department of Urology, University of Bonn, Sigmund Freud Street, 25, D 53105, Bonn, Germany
    Eur Urol 42:289-96. 2002
  2. ncbi Calcium oxalate in plants: formation and function
    Vincent R Franceschi
    School of Biological Sciences, Washington State University, Pullman, Washington 99164 4236, USA
    Annu Rev Plant Biol 56:41-71. 2005
  3. doi Mechanism of calcium oxalate renal stone formation and renal tubular cell injury
    Masao Tsujihata
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Urol 15:115-20. 2008
  4. ncbi Are calcium oxalate crystals involved in the mechanism of acute renal failure in ethylene glycol poisoning?
    Kenneth McMartin
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Clin Toxicol (Phila) 47:859-69. 2009
  5. doi Unique calcium oxalate "duplex" and "concretion" idioblasts in leaves of tribe Naucleeae (Rubiaceae)
    Nels R Lersten
    Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, IA 50011 1020, USA
    Am J Bot 98:1-11. 2011
  6. pmc Kidney stone disease
    Fredric L Coe
    Renal Section, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 115:2598-608. 2005
  7. ncbi The role of overweight and obesity in calcium oxalate stone formation
    Roswitha Siener
    Division of Experimental Urology, Department of Urology, University of Bonn, Bonn, Germany
    Obes Res 12:106-13. 2004
  8. ncbi Metabolic risk factors in pediatric and adult calcium oxalate urinary stone formers: is there any difference?
    Ahmet Tefekli
    Department of Urology, Medical Faculty of Istanbul, University of Istanbul, Turkey
    Urol Int 70:273-7. 2003
  9. pmc History, epidemiology and regional diversities of urolithiasis
    Michelle Lopez
    Department of Nephrology, Hospital de Niños JM de los Ríos, Caracas, Venezuela
    Pediatr Nephrol 25:49-59. 2010
  10. ncbi Renal cell osteopontin production is stimulated by calcium oxalate monohydrate crystals
    J C Lieske
    Department of Medicine, University of Chicago, Illinois, USA
    Kidney Int 51:679-86. 1997

Detail Information

Publications280 found, 100 shown here

  1. ncbi The effect of different diets on urine composition and the risk of calcium oxalate crystallisation in healthy subjects
    Roswitha Siener
    Division of Experimental Urology, Department of Urology, University of Bonn, Sigmund Freud Street, 25, D 53105, Bonn, Germany
    Eur Urol 42:289-96. 2002
    The aim of the study was to determine the impact of defined diet modifications on urine composition and the risk of calcium oxalate crystallisation.
  2. ncbi Calcium oxalate in plants: formation and function
    Vincent R Franceschi
    School of Biological Sciences, Washington State University, Pullman, Washington 99164 4236, USA
    Annu Rev Plant Biol 56:41-71. 2005
    b>Calcium oxalate (CaOx) crystals are distributed among all taxonomic levels of photosynthetic organisms from small algae to angiosperms and giant gymnosperms. Accumulation of crystals by these organisms can be substantial...
  3. doi Mechanism of calcium oxalate renal stone formation and renal tubular cell injury
    Masao Tsujihata
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Urol 15:115-20. 2008
    Formation of calcium oxalate stones tends to increase with age and begins from the attachment of a crystal formed in the cavity of renal tubules to the surface of renal tubular epithelial cells...
  4. ncbi Are calcium oxalate crystals involved in the mechanism of acute renal failure in ethylene glycol poisoning?
    Kenneth McMartin
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Clin Toxicol (Phila) 47:859-69. 2009
    ..The mechanism has not been established but is thought to result from the production of a toxic metabolite...
  5. doi Unique calcium oxalate "duplex" and "concretion" idioblasts in leaves of tribe Naucleeae (Rubiaceae)
    Nels R Lersten
    Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, IA 50011 1020, USA
    Am J Bot 98:1-11. 2011
    ..Here, we surveyed Naucleeae (103 of 179 species, 23 of 24 genera, all seven subtribes) for "duplex idioblast" distribution for systematic significance and describe examples of this rare feature...
  6. pmc Kidney stone disease
    Fredric L Coe
    Renal Section, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 115:2598-608. 2005
    ..Approximately 80% of stones are composed of calcium oxalate (CaOx) and calcium phosphate (CaP); 10% of struvite (magnesium ammonium phosphate produced during infection ..
  7. ncbi The role of overweight and obesity in calcium oxalate stone formation
    Roswitha Siener
    Division of Experimental Urology, Department of Urology, University of Bonn, Bonn, Germany
    Obes Res 12:106-13. 2004
    The aim of the study was to assess the influence of overweight and obesity on the risk of calcium oxalate stone formation.
  8. ncbi Metabolic risk factors in pediatric and adult calcium oxalate urinary stone formers: is there any difference?
    Ahmet Tefekli
    Department of Urology, Medical Faculty of Istanbul, University of Istanbul, Turkey
    Urol Int 70:273-7. 2003
    ..The aim of this study is to compare the metabolic risk factors and saturation of urine in pediatric and adult calcium oxalate (Ca-Ox) stone formers.
  9. pmc History, epidemiology and regional diversities of urolithiasis
    Michelle Lopez
    Department of Nephrology, Hospital de Niños JM de los Ríos, Caracas, Venezuela
    Pediatr Nephrol 25:49-59. 2010
    ..the past decades have affected the incidence and also the site and chemical composition of calculi, with calcium oxalate stones being now the most prevalent...
  10. ncbi Renal cell osteopontin production is stimulated by calcium oxalate monohydrate crystals
    J C Lieske
    Department of Medicine, University of Chicago, Illinois, USA
    Kidney Int 51:679-86. 1997
    ..human osteopontin (OPN), block adhesion to renal tubular cells of the most common crystal in kidney stones, calcium oxalate monohydrate (COM)...
  11. pmc Antioxidant properties of polysaccharide from the brown seaweed Sargassum graminifolium (Turn.), and its effects on calcium oxalate crystallization
    Chao Yan Zhang
    Shanghai Key Laboratory of Functional Materials Chemistry, Research Center of Analysis and Testing, East China University of Science and Technology, Shanghai 200237, China
    Mar Drugs 10:119-30. 2012
    We investigated the effects of polysaccharides from the brown seaweed Sargassum graminifolium (Turn.) (SGP) on calcium oxalate crystallization, and determined its antioxidant activities...
  12. ncbi Decreased inhibitory activity of prothrombin to calcium oxalate crystallization by specific chemical modification of its gamma-carboxyglutamic acid residues
    Jihong Liu
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Urology 67:201-3. 2006
    To investigate the inhibitory role of gamma (gamma)-carboxyglutamic acid (Gla) in the Gla domain of urinary prothrombin in the formation of calcium oxalate crystals.
  13. ncbi Influence of cranberry juice on the urinary risk factors for calcium oxalate kidney stone formation
    T McHarg
    Department of Medicine, University of Cape Town, Cape Town, South Africa
    BJU Int 92:765-8. 2003
    ..the potential influence of cranberry juice on urinary biochemical and physicochemical risk factors associated with the formation of calcium oxalate kidney stones, as this product might affect the chemical composition of urine.
  14. pmc Calcium oxalate stone formation in the inner ear as a result of an Slc26a4 mutation
    Amiel A Dror
    Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 285:21724-35. 2010
    b>Calcium oxalate stone formation occurs under pathological conditions and accounts for more than 80% of all types of kidney stones...
  15. ncbi The efficacy of dietary intervention on urinary risk factors for stone formation in recurrent calcium oxalate stone patients
    Roswitha Siener
    Department of Urology, University of Bonn, Bonn, Germany
    J Urol 173:1601-5. 2005
    Nutrition is suggested to be the major environmental risk factor in idiopathic calcium oxalate stone disease...
  16. ncbi Effect of A. lanata leaf extract and Vediuppu chunnam on the urinary risk factors of calcium oxalate urolithiasis during experimental hyperoxaluria
    R Selvam
    Department of Medical Biochemistry, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, 600 021, India
    Pharmacol Res 43:89-93. 2001
    ..The drug increases the urine volume, thereby reducing the solubility product with respect to calcium oxalate and other crystallizing salts such as uric acid, which may induce epitaxial deposition of calcium oxalate...
  17. ncbi Prophylaxis of calcium oxalate stones by Herniaria hirsuta on experimentally induced nephrolithiasis in rats
    F Atmani
    Laboratory of Cellular Physiology and Pharmacology, Department of Biology, University Mohammed 1, Oujda, Morocco
    BJU Int 92:137-40. 2003
    ..of a herbal decoction from Herniaria hirsuta, a medicinal plant widely used in Morocco to treat kidney stones, by assessing the effect of oral administration in experimentally induced calcium oxalate (CaOx) nephrolithiasis in rats.
  18. ncbi Lipid peroxidation and its correlations with urinary levels of oxalate, citric acid, and osteopontin in patients with renal calcium oxalate stones
    Ho Shiang Huang
    Department of Urology, National Taiwan University Hospital, Taipei, Taiwan
    Urology 62:1123-8. 2003
    To determine whether lipid peroxidation plays a role in patients with calcium oxalate kidney stones and to determine the correlation of lipid peroxidation with tubular damage and the major urinary risk factors...
  19. ncbi Expression of osteopontin in rat kidneys: induction during ethylene glycol induced calcium oxalate nephrolithiasis
    Saeed R Khan
    Department of Pathology, College of Medicine, University of Florida, Gainesville, Florida, USA
    J Urol 168:1173-81. 2002
    ..is a well-known component of stone matrix and a strong inhibitor of the nucleation, growth and aggregation of calcium oxalate crystals in vitro...
  20. ncbi An oxalate-binding protein with crystal growth promoter activity from human kidney stone matrix
    A Govindaraj
    Department of Medical Biochemistry, Dr A L M PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, India
    BJU Int 90:336-44. 2002
    To fractionate renal-stone matrix proteins, identify the presence of oxalate-binding protein and assess its effect in a calcium oxalate (CaOx) crystal growth system.
  21. doi Effects of a low-salt diet on idiopathic hypercalciuria in calcium-oxalate stone formers: a 3-mo randomized controlled trial
    Antonio Nouvenne
    Department of Clinical Sciences, University of Parma, Parma, Italy
    Am J Clin Nutr 91:565-70. 2010
    ....
  22. ncbi Study of a rat model for calcium oxalate crystal formation without severe renal damage in selected conditions
    Satoshi Yamaguchi
    Department of Medicine, Medical College of Wisconsin and the Department of Veterans Affairs Medical Center, Milwaukee, Wisconsin, USA
    Int J Urol 12:290-8. 2005
    ..in high doses, ethylene glycol (EG) has been used with ammonium chloride (NH(4)Cl) or vitamin D(3) to study calcium oxalate stone formation in rat models...
  23. ncbi Essential arterial hypertension and stone disease
    L Borghi
    Institutes of Semeiotica Medica, University of Parma, Italy
    Kidney Int 55:2397-406. 1999
    ..Cross-sectional studies have shown that nephrolithiasis is more frequently found in hypertensive patients than in normotensive subjects, but the pathogenic link between hypertension and stone disease is still not clear...
  24. pmc Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion
    Shrikant R Mulay
    Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Munich, Germany
    J Clin Invest 123:236-46. 2013
    Nephrocalcinosis, acute calcium oxalate (CaOx) nephropathy, and renal stone disease can lead to inflammation and subsequent renal failure, but the underlying pathological mechanisms remain elusive...
  25. pmc Diet, but not oral probiotics, effectively reduces urinary oxalate excretion and calcium oxalate supersaturation
    John C Lieske
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 78:1178-85. 2010
    ..effect of a controlled diet and two probiotic preparations on urinary oxalate excretion, a risk factor for calcium oxalate kidney stone formation, in patients with mild hyperoxaluria...
  26. ncbi Calcium oxalate crystals in fetal bovine serum: implications for cell culture, phagocytosis and biomineralization studies in vitro
    Claudio E Pedraza
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada H3A 2B2
    J Cell Biochem 103:1379-93. 2008
    ..we report that commercially available FBS from different major suppliers consistently contain precipitated, calcium oxalate crystals-either in the monohydrate (COM) or dihydrate (COD) form...
  27. doi Infrared spectroscopic analysis of 5,248 urinary stones from Chinese patients presenting with the first stone episode
    Xizhao Sun
    Department of Urology, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008 Jiangsu, China
    Urol Res 39:339-43. 2011
    ..The overall sex ratio (male:female) was 2.34:1. Results showed that the preponderant type of stone was calcium oxalate, followed by carbapatite, anhydrous uric acid, struvite and cystine...
  28. ncbi Reduced crystallization inhibition by urine from women with nephrolithiasis
    John R Asplin
    Renal Section, University of Chicago, and Litholink Corporation, Chicago, Illinois 60637, USA
    Kidney Int 61:1821-9. 2002
    Human urine is known to inhibit growth, aggregation, nucleation, and cell adhesion of calcium oxalate monohydrate (COM) crystals, the main solid phase of human kidney stones...
  29. ncbi Inhibition of growth and aggregation of calcium oxalate crystals in vitro--a comparison of four human proteins
    P K Grover
    Department of Surgery, Flinders Medical Centre, Adelaide, South Australia, Australia
    Eur J Biochem 253:637-44. 1998
    ..glycoprotein (THG), human serum albumin (HSA), alpha1-microglobulin and prothrombin fragment 1 (PTF1) on calcium oxalate crystallization...
  30. ncbi Fibronectin inhibits endocytosis of calcium oxalate crystals by renal tubular cells
    Masao Tsujihata
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 13:743-6. 2006
    ..reported that FN has a protective effect against injury of renal tubular cells by exposure to oxalate and calcium oxalate (CaOX) crystals and inhibits the adhesion of CaOX crystals to renal tubular cells...
  31. ncbi Glycosylation of prothrombin fragment 1 governs calcium oxalate crystal nucleation and aggregation, but not crystal growth
    Dawn Webber
    Department of Chemistry, University of Cape Town, Private Bag, Rondebosch, Cape Town, 7701, South Africa
    Urol Res 35:277-85. 2007
    Urinary glycoproteins play an important role in the modulation of calcium oxalate crystallisation...
  32. ncbi Urine protein markers distinguish stone-forming from non-stone-forming relatives of calcium stone formers
    Kristin J Bergsland
    Litholink Corp, 2250 W Campbell Park Dr, Chicago, IL 60612, USA
    Am J Physiol Renal Physiol 291:F530-6. 2006
    We have investigated urine protein inhibitors of calcium oxalate crystallization to determine whether variations in these proteins are associated with kidney stone disease and whether protein measurements improve the identification of ..
  33. ncbi Morphology, particle size distribution, aggregation, and crystal phase of nanocrystallites in the urine of healthy persons and lithogenic patients
    Jie Yu He
    Institute of Biomineralization and Lithiasis Research and the Department of Chemistry, Jinan University, Guangzhou 510632, China
    IEEE Trans Nanobioscience 9:156-63. 2010
    ..The formed nuclei then grow or/and aggregate to a pathological size. Thus, the nanocrystallites in urine may be related to the formation of urinary stones...
  34. pmc Physiopathology and etiology of stone formation in the kidney and the urinary tract
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Ms 5055, Indianapolis, IN 46220, USA
    Pediatr Nephrol 25:831-41. 2010
    ..of a renal papilla at sites of interstitial apatite plaque (termed Randall's plaque), as seen in idiopathic calcium oxalate stone formers; (2) stones attached to plugs protruding from the openings of ducts of Bellini, as seen in ..
  35. ncbi Effects of an aqueous extract from Phyllantus niruri on calcium oxalate crystallization in vitro
    M E Barros
    Nephrology Division, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Urol Res 30:374-9. 2003
    ..no toxicity, potentially increases calculus voiding by stone forming patients and inhibits the endocytosis of calcium oxalate (CaOx) crystals by MDCK cells. In addition, in a rat model of urolithiasis it reduced calculus growth...
  36. ncbi Effect of Aerva lanata on calcium oxalate urolithiasis in rats
    P Soundararajan
    Department of Siddha Medicine, Faculty of Science, Tamil University, Thanjavur 613 005, India
    Indian J Exp Biol 44:981-6. 2006
    b>Calcium oxalate (CaOx) stone was induced in rats using 0.75% of ethylene glycol in drinking water for 28 days...
  37. ncbi Antiurolithic effect of Bergenia ligulata rhizome: an explanation of the underlying mechanisms
    Samra Bashir
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 122:106-16. 2009
    ..Bergenia ligulata is widely used plant in South Asia, mainly India and Pakistan, as a traditional medicine for treatment of urolithiasis...
  38. ncbi Oxalate and calcium oxalate mediated free radical toxicity in renal epithelial cells: effect of antioxidants
    Sivagnanam Thamilselvan
    Department of Urology 2D, Vattikuti Urology Institute and Henry Ford Health Sciences Center, One Ford Place, Detroit, MI 48202, USA
    Urol Res 31:3-9. 2003
    In a previous study we demonstrated that oxalate induced free radical injury can promote calcium oxalate stone formation...
  39. ncbi Dietary therapy in idiopathic nephrolithiasis
    Loris Borghi
    Dipartimento di Scienze Cliniche, Universita di Parma, Italy
    Nutr Rev 64:301-12. 2006
    ..The final part of the paper will provide practical guidelines for pursuing an anti-lithogenic diet in idiopathic calcium and uric acid stones...
  40. ncbi Supplementation of vitamin E and selenium prevents hyperoxaluria in experimental urolithic rats
    Mani Santhosh Kumar
    Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
    J Nutr Biochem 14:306-13. 2003
    Renal injury is considered as one of the prerequisites for calcium oxalate retention...
  41. ncbi Preventive effects of green tea on renal stone formation and the role of oxidative stress in nephrolithiasis
    Yasunori Itoh
    Department of Surgical Medicine, Nephro Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya City, Aichi 467 8601, Japan
    J Urol 173:271-5. 2005
    ..Green tea leaves contain approximately 13% catechins, which have been shown to have antioxidant effects. We investigated the inhibitory, antioxidative effects of green tea on calcium urinary stone formation...
  42. ncbi Crystal-induced inflammation of the kidneys: results from human studies, animal models, and tissue-culture studies
    Saeed R Khan
    Department of Pathology, College of Medicine, University of Florida, Gainesville, FL 32610 0275, USA
    Clin Exp Nephrol 8:75-88. 2004
    b>Calcium oxalate (CaOx), calcium phosphate (CaP), and uric acid or urate are the most common crystals seen in the kidneys...
  43. ncbi Control of calcium oxalate crystal growth by face-specific adsorption of an osteopontin phosphopeptide
    Bernd Grohe
    CIHR Group in Skeletal Development and Remodeling, School of Dentistry, University of Western Ontario, London, Canada
    J Am Chem Soc 129:14946-51. 2007
    ..of control, we are studying the interaction between the phosphoprotein osteopontin (OPN) and the biomineral calcium oxalate monohydrate (COM)...
  44. ncbi The effect of Phyllanthus niruri on urinary inhibitors of calcium oxalate crystallization and other factors associated with renal stone formation
    A M Freitas
    Nephrology Division, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil
    BJU Int 89:829-34. 2002
    ..To evaluate the effect of an aqueous extract of Phyllanthus niruri (Pn), a plant used in folk medicine to treat lithiasis, on the urinary excretion of endogenous inhibitors of lithogenesis, citrate, magnesium and glycosaminoglycans (GAGs)...
  45. ncbi Predictive value of kidney stone composition in the detection of metabolic abnormalities
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Am J Med 115:26-32. 2003
    ..To determine if kidney stone composition can predict the underlying medical diagnosis, and vice versa...
  46. ncbi Hyperoxaluria-induced oxidative stress and antioxidants for renal protection
    Saeed R Khan
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida 32610, USA
    Urol Res 33:349-57. 2005
    ....
  47. pmc Oxalobacter formigenes may reduce the risk of calcium oxalate kidney stones
    David W Kaufman
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    J Am Soc Nephrol 19:1197-203. 2008
    Most kidney stones are composed primarily of calcium oxalate. Oxalobacter formigenes is a Gram-negative, anaerobic bacterium that metabolizes oxalate in the intestinal tract and is present in a large proportion of the normal adult ..
  48. ncbi Identification of myeloperoxidase, alpha-defensin and calgranulin in calcium oxalate renal stones
    Shamim Mushtaq
    Department of Biological and Biomedical Sciences, Research Laboratory, Juma Building, Pakistan
    Clin Chim Acta 384:41-7. 2007
    ..We characterized proteins from the inner core and outer matrix of calcium oxalate (CaOx) renal stones.
  49. ncbi Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both
    Lan Mo
    Dept of Urology, New York Univ School of Medicine, Veterans Affairs Medical Center in Manhattan, 423 E23 St, Rm 18064S, New York, NY 10010, USA
    Am J Physiol Renal Physiol 293:F1935-43. 2007
    Although often supersaturated with mineral salts such as calcium phosphate and calcium oxalate, normal urine possesses an innate ability to keep them from forming harmful crystals...
  50. ncbi Effects of urine dilution on quantity, size and aggregation of calcium oxalate crystals induced in vitro by an oxalate load
    Angela Guerra
    Department of Clinical Sciences, University of Parma, Parma, Italy
    Clin Chem Lab Med 43:585-9. 2005
    ..This study aimed at assessing how urine dilution affects urinary calcium oxalate crystallization...
  51. doi Cooperation of phosphates and carboxylates controls calcium oxalate crystallization in ultrafiltered urine
    Bernd Grohe
    Department of Dentistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada
    Urol Res 39:327-38. 2011
    ..present study, we investigate the roles of phosphate and carboxylate groups in the OPN-mediated modulation of calcium oxalate (CaOx), the principal mineral phase found in kidney stones...
  52. ncbi Probiotics and dietary manipulations in calcium oxalate nephrolithiasis: two sides of the same coin?
    Loris Borghi
    Department of Clinical Sciences, University of Parma, Parma, Italy
    Kidney Int 78:1063-5. 2010
    ..However, the discrepancy between in vitro and in vivo results requires further studies to identify the right patient target, the correct dosage, and the real modification of natural and clinical history of nephrolithiasis...
  53. ncbi Heavy metal stress reduces the deposition of calcium oxalate crystals in leaves of Phaseolus vulgaris
    David Jáuregui-Zúñiga
    Departamento de Bioquimica, Instituto de Quimica, UNAM, Circuito Exterior, CU Mexico
    J Plant Physiol 162:1183-7. 2005
    b>Calcium oxalate (CaOx) crystals in plants may serve as a sink for the absorption of excess calcium, and they could play an important role in heavy metal detoxification...
  54. doi Oxidative renal cell injury induced by calcium oxalate crystal and renoprotection with antioxidants: a possible role of oxidative stress in nephrolithiasis
    Mauricio Davalos
    Department of Urology, New York Medical College, Valhalla, New York 10595, USA
    J Endourol 24:339-45. 2010
    b>Calcium oxalate (CaOx) is one of the key elements for kidney stone formation, but the exact mechanism needs to be defined...
  55. doi Effect of dietary water intake on urinary output, specific gravity and relative supersaturation for calcium oxalate and struvite in the cat
    Catherine M F Buckley
    Waltham Centre for Pet Nutrition, Freeby Lane, Waltham on the Wolds, Melton Mowbray, Leicestershire LE14 4RT, UK
    Br J Nutr 106:S128-30. 2011
    ..urine volume, water drunk and total fluid intake were measured daily; relative supersaturation (RSS) for calcium oxalate (CaOx) and struvite was calculated using the SUPERSAT computer program. Cats fed the 73...
  56. ncbi Citric acid or citrates in urine: which should we focus on in the prevention of calcium oxalate crystals and stones?
    Norbert Laube
    Division of Experimental Urology, Department of Urology, Bonn University, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Urol Res 30:336-41. 2002
    ..58 calcium stone formers, were investigated for pH, citric acid concentration ([CA]), and related relative calcium oxalate supersaturation (RS)...
  57. doi Altered proteins in MDCK renal tubular cells in response to calcium oxalate dihydrate crystal adhesion: a proteomics approach
    Theptida Semangoen
    Medical Proteomics Unit and Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 7:2889-96. 2008
    ..kidney (MDCK) cells, which were derived from dog kidney and exhibited distal renal tubule phenotype, during calcium oxalate dihydrate (COD) crystal adhesion...
  58. ncbi Intracrystalline proteins and urolithiasis: a comparison of the protein content and ultrastructure of urinary calcium oxalate monohydrate and dihydrate crystals
    Rosemary L Ryall
    Department of Surgery, Flinders Medical Centre and Flinders University School of Medicine, Bedford Park, South Australia
    BJU Int 96:654-63. 2005
    To compare the ultrastructure and protein content, particularly prothrombin fragment 1 and osteopontin, of calcium oxalate monohydrate (COM) and calcium oxalate dihydrate (COD) crystals precipitated from human urine, and their ..
  59. ncbi Effect of prothrombin and its activation fragments on calcium oxalate crystal growth and aggregation in undiluted human urine in vitro: relationship between protein structure and inhibitory activity
    Phulwinder K Grover
    Urology Unit, Department of Surgery, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia
    Clin Sci (Lond) 102:425-34. 2002
    ..and its activation peptides, especially the urinary form of prothrombin fragment 1, in the pathogenesis of calcium oxalate (CaOx) urolithiasis...
  60. pmc Phenotypic and functional analysis of human SLC26A6 variants in patients with familial hyperoxaluria and calcium oxalate nephrolithiasis
    Carla G Monico
    Mayo Clinic Hyperoxaluria Center, Division of Nephrology and Hypertension, Departments of Internal Medicine and Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Kidney Dis 52:1096-103. 2008
    Urinary oxalate is a major risk factor for calcium oxalate stones. Marked hyperoxaluria arises from mutations in 2 separate loci, AGXT and GRHPR, the causes of primary hyperoxaluria (PH) types 1 (PH1) and 2 (PH2), respectively...
  61. ncbi Vitamin E therapy prevents hyperoxaluria-induced calcium oxalate crystal deposition in the kidney by improving renal tissue antioxidant status
    Sivagnanam Thamilselvan
    Department of Urology, Ste 2D 34, Henry Ford Health System, One Ford Place, Detroit, MI 48202, USA
    BJU Int 96:117-26. 2005
    To determine whether vitamin E prevents hyperoxaluria-induced stone formation, using a new animal model of calcium oxalate stone disease, as our previous in- vitro and in-vivo studies showed that oxalate and hyperoxaluria induce free-..
  62. ncbi Association between dietary factors and calcium oxalate and magnesium ammonium phosphate urolithiasis in cats
    C Lekcharoensuk
    Minnesota Urolith Center, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA
    J Am Vet Med Assoc 219:1228-37. 2001
    OBJECTIVE: To identify dietary factors associated with the increase in occurrence of calcium oxalate (CaOx) uroliths and the decrease in occurrence of magnesium ammonium phosphate (MAP) uroliths in cats. DESIGN: Case-control study...
  63. ncbi Inhibition of calcium oxalate crystal growth and aggregation by prothrombin and its fragments in vitro: relationship between protein structure and inhibitory activity
    P K Grover
    Urology Unit, Department of Surgery, Flinders Medical Centre, Flinders University of South Australia
    Eur J Biochem 263:50-6. 1999
    ..One of these fragments, F1, is excreted in human urine and is the principal protein occluded into calcium oxalate (CaOx) crystals precipitated from it...
  64. doi Pharmacological and toxicological effects of Paronychia argentea in experimental calcium oxalate nephrolithiasis in rats
    S Bouanani
    Departement de Chimie, Laboratoire de Chimie Bioorganique, Universite Badji Mokhtar, Annaba, Algeria
    J Ethnopharmacol 129:38-45. 2010
    ..This study was carried out to determine whether the aqueous extract (APA) or the butanolic extract (BPA) of aerial parts could prevent or reduce calculi aggregation in experimental calcium oxalate (Ox) nephrolithiasis in Wistar rats.
  65. ncbi Role of crystal surface adhesion in kidney stone disease
    Jeffrey A Wesson
    Department of Medicine Nephrology, The Medical College of Wisconsin, Milwaukee, Wisconsin 53295, USA
    Curr Opin Nephrol Hypertens 15:386-93. 2006
    Atomic force microscopy has been used recently to characterize the adhesion force between selected calcium oxalate crystal surfaces and biologically relevant chemical groups attached to the atomic force microscopy probe tip...
  66. pmc Renal lithiasis and nutrition
    Felix Grases
    Laboratory of Renal Lithiasis Research, Universitary Institute of Health Sciences Research IUNICS, University of Balearic Islands, E 07122 Palma de Mallorca, Spain
    Nutr J 5:23. 2006
    ..intake, pH, calcium, phosphate, oxalate, citrate, phytate, urate and vitamins) and each type of renal stone (calcium oxalate monohydrate papillary, calcium oxalate monohydrate unattached, calcium oxalate dihydrate, calcium oxalate ..
  67. ncbi Chinese herbal medicines and their efficacy in treating renal stones
    Mayur Danny I Gohel
    Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Urol Res 34:365-72. 2006
    ..Previous clinical studies have shown that herbal medicines and their concoctions could be used to inhibit calcium oxalate crystallization...
  68. ncbi Changes in urinary parameters after oral administration of potassium-sodium citrate and magnesium oxide to prevent urolithiasis
    Yuji Kato
    Department of Urology, Asahikawa Medical College, Asahikawa, Japan
    Urology 63:7-11; discussion 11-2. 2004
    To examine urinary parameters among normal individuals and patients with calcium oxalate (CaOx) stones after oral administration of potassium-sodium citrate (KNa-Cit) and magnesium oxide (MgO)...
  69. pmc Primary hyperoxaluria type III gene HOGA1 (formerly DHDPSL) as a possible risk factor for idiopathic calcium oxalate urolithiasis
    Carla G Monico
    Mayo Clinic Hyperoxaluria Center, Divisions of Nephrology and Hypertension, and Biomedical Statisticsand Informatics, MayoClinic, Rochester, Minnesota, USA
    Clin J Am Soc Nephrol 6:2289-95. 2011
    Primary hyperoxaluria types I and II (PHI and PHII) are rare monogenic causes of hyperoxaluria and calcium oxalate urolithiasis...
  70. doi Ethylene glycol induces calcium oxalate crystal deposition in Malpighian tubules: a Drosophila model for nephrolithiasis/urolithiasis
    Yung Hsiang Chen
    Graduate Institute of Integrated Medicine, Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung, Taiwan
    Kidney Int 80:369-77. 2011
    Several animal species are used to study calcium oxalate urolithiasis; however, an ideal model has yet to be identified...
  71. ncbi Urinary stone analysis of 1,000 patients in southern Taiwan
    Yii Her Chou
    Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 23:63-6. 2007
    ..Stone components were analyzed by Fourier transform infrared spectroscopy. Mixed components of calcium oxalate and calcium phosphate were the most common form of stones (52.3%), followed by calcium oxalate (27...
  72. ncbi Genes in idiopathic calcium oxalate stone disease
    H O Goodman
    Department of Urology, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC 27157, USA
    World J Urol 15:186-94. 1997
    ..The identification of the genes involved should be facilitated by the reduction of dietary influences on urinary excretions through the use of formula diets...
  73. ncbi Crystallization inhibitors in the pathophysiology and treatment of nephrolithiasis
    Martino Marangella
    Division of Nephrology, Dialysis and Renal Stone Centre, Mauriziano Hospital, Torino, Italy
    Urol Int 72:6-10. 2004
    ..Several studies in the last two decades have identified many inhibitors of calcium oxalate and calcium phosphate crystallization, which are classified into the ionic and macromolecular...
  74. ncbi Brain death with calcium oxalate deposition in the kidney: clue to the diagnosis of ethylene glycol poisoning
    Shirushi Takahashi
    Division of Forensic Medicine, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, 980 8575 Sendai, Japan
    Leg Med (Tokyo) 10:43-5. 2008
    ..Autopsy revealed acute tubular necrosis of the kidneys with significant calcium oxalate depositions. The brain was markedly softening and with chronic meningoencephalitis and dural sinus thrombosis...
  75. pmc In idiopathic calcium oxalate stone-formers, unattached stones show evidence of having originated as attached stones on Randall's plaque
    Nicole L Miller
    Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BJU Int 105:242-5. 2010
    To analyse the structure and composition of unattached stones in idiopathic calcium oxalate (CaOx) stone-formers (ICSF) and compare them to attached stones from the same cohort, to investigate whether there is more than one pathogenic ..
  76. pmc Superoxide from NADPH oxidase as second messenger for the expression of osteopontin and monocyte chemoattractant protein-1 in renal epithelial cells exposed to calcium oxalate crystals
    Tohru Umekawa
    Department of Urology, Kinki University School of Medicine, Osaka, Japan
    BJU Int 104:115-20. 2009
    OBJECTIVE To test the hypothesis that exposure of a renal epithelial cell line, NRK52E, to calcium oxalate monohydrate crystals (COM) would up-regulate NADPH oxidase subunit p47(phox), enhance superoxide production and increase monocyte ..
  77. ncbi Changes in urinary stone risk factors in hypocitraturic calcium oxalate stone formers treated with dietary sodium supplementation
    Marshall L Stoller
    Department of Urology, School of Medicine, University of California San Francisco, San Francisco, California, USA
    J Urol 181:1140-4. 2009
    ..We investigated the effects of supplemental dietary sodium on risk factors for urinary stone disease in stone forming patients with hypocitraturia...
  78. doi Changes in stone composition according to age in Tunisian pediatric patients
    Akram Alaya
    Department of Biochemistry and Toxicology, University Hospital, 5000 Monastir, Tunisia
    Int Urol Nephrol 42:621-8. 2010
    The epidemiology of renal stones has changed all over the world toward a predominance of calcium oxalate stones...
  79. ncbi Analysis of urinary calculi obtained from a patient with idiopathic hypouricemia using micro area x-ray diffractometry and LC-MS
    Kiyoko Kaneko
    Department of Analytical Chemistry, School of Pharmaceutical Sciences, Teikyo University, Suwarashi 1091 1, Sagamiko cho, Tsukui gun, Kanagawa, 199 0195, Tokyo, Japan
    Urol Res 33:415-21. 2005
    ..Analysis with the microarea x-ray diffractometer showed that one of the calculi was composed of calcium oxalate monohydrate and hydroxyapatite. The other was found to be formed from calcium oxalate dihydrate...
  80. pmc An aqueous extract of Ammi visnaga fruits and its constituents khellin and visnagin prevent cell damage caused by oxalate in renal epithelial cells
    P Vanachayangkul
    Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, PO Box 100494, FL 32610, USA
    Phytomedicine 17:653-8. 2010
    ..LLC-PK1 and MDCK cell lines were exposed to 300 microM oxalate (Ox) or 133 microg/cm(2) calcium oxalate monohydrate (COM) in presence or absence of 10, 50, 100 or 200 microg/mL KE...
  81. ncbi Risk factors associated to kidney stones in primary hyperparathyroidism
    S Corbetta
    Institute of Endocrine Sciences, Fondazione Ospedale Maggiore IRCCS, University of Milan, Milan, Italy
    J Endocrinol Invest 28:122-8. 2005
    ..Hypercalciuria was often concomitant with massive quantities of calcium oxalate crystals in urine sediment...
  82. ncbi Clinicopathological features and CD57 expression in renal cell carcinoma in acquired cystic disease of the kidneys: with special emphasis on a relation to the duration of haemodialysis, the degree of calcium oxalate deposition, histological type, and poss
    Yasuyuki Enoki
    Department of Pathology and Laboratory Medicine, Kyoto First Red Cross Hospital, and Hospital Department of Pathology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Histopathology 56:384-94. 2010
    ..The aims were to analyse the histological findings of ACDK-RCC and to determine its histogenesis...
  83. ncbi Effects of an extract from Herniaria hirsuta on calcium oxalate crystallization in vitro
    F Atmani
    Laboratory of Cellular Physiology and Pharmacology, University Mohammed the First, Faculty of Sciences, Department of Biology, Oujda Morocco
    BJU Int 85:621-5. 2000
    To evaluate the effectiveness of an extract obtained from Herniaria hirsuta on calcium oxalate crystallization in vitro. Materials and methods An extract was prepared from H. hirsuta at different concentrations (0.0625-1 mg/mL)...
  84. ncbi Risk of calcium oxalate nephrolithiasis in postmenopausal women supplemented with calcium or combined calcium and estrogen
    Somnuek Domrongkitchaiporn
    Department of Medicine, Ramathibodi Hospital, Mahidol University, Rama 6, Bangkok 10400, Thailand
    Maturitas 41:149-56. 2002
    ..However, the safety of the treatments in terms of the risk of calcium oxalate stone formation is unknown...
  85. doi Calcium oxalate: calcium phosphate transformations
    George H Nancollas
    University at Buffalo, Amherst, NY 14260, USA
    Urol Res 38:277-80. 2010
    ..If these modifications are made during the initial stages of crystallite nucleation, they could potentially reduce the participation of phases such as Randall's plaques in stone formation...
  86. doi Proteome of human calcium kidney stones
    Benjamin K Canales
    Department of Urology, University of Minnesota, Minneapolis, Minnesota, USA
    Urology 76:1017.e13-20. 2010
    Idiopathic calcium oxalate (CaOx) stones are believed to develop attached to papillary subepithelial deposits called Randall's plaques...
  87. doi Antiurolithic effect of berberine is mediated through multiple pathways
    Samra Bashir
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Eur J Pharmacol 651:168-75. 2011
    ..in vitro for the antioxidant effect and in vivo for diuretic and antiurolithic effects on an animal model of calcium oxalate urolithiasis...
  88. ncbi In vitro effect of lemon and orange juices on calcium oxalate crystallization
    Sevsen Kulaksizoglu
    Department of Biochemistry, Faculty of Medicine, Baskent University, Konya, Turkey
    Int Urol Nephrol 40:589-94. 2008
    ..The ability of urine to inhibit calcium oxalate crystallization is an important mechanism against stone formation...
  89. pmc Idiopathic recurrent calcium urolithiasis (IRCU): variation of fasting urinary protein is a window to pathophysiology or simple consequence of renal stones in situ? A tripartite study in male patients providing insight into oxidative metabolism as possibl
    Paul O Schwille
    Mineral Metabolism and Endocrine Research Laboratory, Departments of Surgery and Urology, University of Erlangen Nurnberg, Germany
    Eur J Med Res 14:378-92. 2009
    ..In IRCU it is uncertain whether variation of urinary protein, especially non-albumin protein (N-Alb-P), is due to the presence of stones or reflects alteration of oxidative metabolism...
  90. ncbi Citrate provides protection against oxalate and calcium oxalate crystal induced oxidative damage to renal epithelium
    Karen Byer
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida 32610 0275, USA
    J Urol 173:640-6. 2005
    Oxalate and calcium oxalate (CaOx) crystals are injurious to renal epithelial cells. The injury is caused by the production of reactive oxygen species (ROS)...
  91. ncbi Calcium oxalate crystallization in untreated urine, centrifuged and filtered urine and ultrafiltered urine
    Angela Guerra
    Department of Clinical Sciences, University of Parma, Parma, Italy
    Clin Chem Lab Med 42:45-50. 2004
    Centrifuged and filtered urine is often used to evaluate in vitro the crystallization processes of calcium oxalate (CaOx), but even such simple manipulations can alter the composition of the urine, as regards its protein and lipid ..
  92. ncbi Concentrated urine and diluted urine: the effects of citrate and magnesium on the crystallization of calcium oxalate induced in vitro by an oxalate load
    Angela Guerra
    Department of Clinical Sciences, University of Parma, Parma, Italy
    Urol Res 34:359-64. 2006
    ..b>Calcium oxalate crystallization was studied on 4-h urine of 20 male idiopathic calcium oxalate stone formers, first under low ..
  93. doi Second prize: Comprehensive proteomic analysis of human calcium oxalate monohydrate kidney stone matrix
    Benjamin K Canales
    Department of Urologic Surgery, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA
    J Endourol 22:1161-7. 2008
    ..Our study objective is to characterize the matrix of calcium oxalate monohydrate (COM) stones using a comprehensive proteomics approach.
  94. doi Genome-wide analysis of genes related to kidney stone formation and elimination in the calcium oxalate nephrolithiasis model mouse: detection of stone-preventive factors and involvement of macrophage activity
    Atsushi Okada
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Nagoya City, Aichi, Japan
    J Bone Miner Res 24:908-24. 2009
    ..Furthermore, we showed that the generated calcium oxalate crystal deposits could be eliminated after several days...
  95. ncbi Impact of urine sodium on urine risk factors for calcium oxalate nephrolithiasis
    Brian H Eisner
    Department of Urology, University of California San Francisco, San Francisco, California 94143, USA
    J Urol 182:2330-3. 2009
    ..However, equivocal data exist on whether increased urine sodium actually increases the nephrolithiasis risk. We examined the relationship between urine sodium and urine risk factors for nephrolithiasis...
  96. ncbi Osteocalcin gene Hind III polymorphism is not correlated with calcium oxalate stone disease
    W C Chen
    Department of Urology, China Medical College Hospital, Taichung, Taiwan
    Urol Res 29:98-101. 2001
    ..In our study, a normal control group of 105 healthy people and 102 patients with calcium oxalate stones were examined...
  97. ncbi Mechanisms of calcium oxalate crystal attachment to injured renal collecting duct cells
    J H Wiessner
    Department of Medicine, Medical College of Wisconsin and Department of Veterans Affairs Medical Center, Milwaukee, Wisconsin, USA
    Kidney Int 59:637-44. 2001
    ..V was used to determine whether phosphatidylserine (PS) exposure on the cell membrane surface plays a role in calcium oxalate monohydrate (COM) crystal attachment to cells that have lost their polarity as well as to cells that have ..
  98. doi Red blood cell membrane fragments but not intact red blood cells promote calcium oxalate monohydrate crystal growth and aggregation
    Somchai Chutipongtanate
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine, Siriraj Hospital and Center for Research in Complex Systems Sciences, Mahidol University, Bangkok, Thailand
    J Urol 184:743-9. 2010
    Cell membranes are thought to promote calcium oxalate kidney stone formation but to our knowledge the modulating effect of red blood cell membranes on calcium oxalate crystals has not been previously investigated...
  99. ncbi Acute effects of calcium sodium citrate supplementation of a test meal on mineral homeostasis, oxalate, and calcium oxalate crystallization in the urine of healthy humans--preliminary results in patients with idiopathic calcium urolithiasis
    U Herrmann
    Department of Surgery, University of Erlangen, Germany
    Biomed Pharmacother 53:264-73. 1999
    ..Long-term studies aimed at evaluating the usefulness of CSC in preserving healthy bone, and in the metaphylaxis of renal stones would appear justified...
  100. doi Angiotensin type-1 receptor blocker candesartan inhibits calcium oxalate crystal deposition in ethylene glycol-treated rat kidneys
    Iwao Yoshioka
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    Urology 77:1007.e9-1007.e14. 2011
    To investigate whether an angiotensin type-1 receptor blocker could inhibit calcium oxalate crystal deposition using ethylene glycol-treated rats...
  101. ncbi Serum, urinary and stone zinc, iron, magnesium and copper levels in idiopathic calcium oxalate stone patients
    Irfan H Atakan
    Department of Urology, Faculty of Medicine, University of Trakya, Edirne, Turkey
    Int Urol Nephrol 39:351-6. 2007
    ..was to investigate the urinary, serum and stone levels of zinc, iron, magnesium, and copper in patients with calcium oxalate stones and to investigate urinary and serum element levels in healthy controls and to find a possible ..

Research Grants76

  1. INTER ALPHA TRYPSIN INHIBITOR IN CAOX UROLITHIASIS
    Susan Ruth Marengo; Fiscal Year: 2002
    ..blot analysis of spot and 24 hr urine specimens, we have demonstrated that males who are confirmed active calcium oxalate (CaOx) stone formers (SF) typically expressed inter-alpha-trypsin inhibitor-trimer (IaTI-trimer) whereas age ..
  2. Probiotic-Induced Elimination of Oxalate to Treat Hyperoxaluria Associated with P
    Marguerite Hatch; Fiscal Year: 2010
    ..to a deficiency of the liver enzyme alanine-glyoxylate aminotransferase (AGT), results in hyperoxaluria and calcium oxalate kidney stone formation in addition to tissue deposition of oxalate (oxalosis), renal failure and death unless ..
  3. COATING OF URINARY PROTHESES TO PREVENT ENCRUSTATION
    Harmeet Sidhu; Fiscal Year: 2000
    ..to the biomaterial and form biofilms, a process dependent on the deposition of urinary components (especially calcium oxalate, calcium apatite and struvite) onto the biomaterial...
  4. Identification of a Multi-Analyte Profile for Primary Hyperoxaluria
    James Mapes; Fiscal Year: 2009
    ..in the AGXT gene leads to overproduction of oxalate by the liver, resulting in widespread deposition of calcium oxalate in the kidneys and other organs. Unfortunately, PH1 disease progression is not understood...
  5. EPITHELIAL OXALATE AND CITRATE TRANSPORT
    DAVID BRUCE MOUNT; Fiscal Year: 2011
    ..This phenotypic characterization will be correlated with the impact of these polymorphisms on the genetic predisposition to stone disease and hyperoxaluria, as determined in Project 3. ..
  6. Mechanisms of Oxalobacter-Induced Enteric Oxalate Excretion
    Marguerite Hatch; Fiscal Year: 2009
    Hyperoxaluria is considered to be a major risk factor in calcium oxalate stone disease which occurs in about 12% of the American population and, apart from reducing dietary sources of oxalate, there is currently no pharmacological ..
  7. INTER ALPHA TRYPSIN INHIBITOR IN CAOX UROLITHIASIS
    Susan Ruth Marengo; Fiscal Year: 2000
    ..blot analysis of spot and 24 hr urine specimens, we have demonstrated that males who are confirmed active calcium oxalate (CaOx) stone formers (SF) typically expressed inter-alpha-trypsin inhibitor-trimer (IaTI-trimer) whereas age ..
  8. INTER ALPHA TRYPSIN INHIBITOR IN CAOX UROLITHIASIS
    Susan Ruth Marengo; Fiscal Year: 2001
    ..blot analysis of spot and 24 hr urine specimens, we have demonstrated that males who are confirmed active calcium oxalate (CaOx) stone formers (SF) typically expressed inter-alpha-trypsin inhibitor-trimer (IaTI-trimer) whereas age ..
  9. INTER ALPHA TRYPSIN INHIBITOR IN CAOX UROLITHIASIS
    Susan Ruth Marengo; Fiscal Year: 1999
    ..blot analysis of spot and 24 hr urine specimens, we have demonstrated that males who are confirmed active calcium oxalate (CaOx) stone formers (SF) typically expressed inter-alpha-trypsin inhibitor-trimer (IaTI-trimer) whereas age ..
  10. Mechanisms of Oxalobacter-Induced Enteric Oxalate Excretion
    Marguerite Hatch; Fiscal Year: 2010
    Hyperoxaluria is considered to be a major risk factor in calcium oxalate stone disease which occurs in about 12% of the American population and, apart from reducing dietary sources of oxalate, there is currently no pharmacological ..
  11. REGULATION OF ENTERIC HYPEROXALURI BY OXALOBACTER
    AMMON PECK; Fiscal Year: 2001
    ..it can cause numerous pathological conditions, including hyperoxaluria, cardiac conductance disorders, calcium oxalate stones, renal failure, death and possibly inflammatory bowel disease and vulvovestibulitis...
  12. REGULATION OF ENTERIC HYPEROXALURI BY OXALOBACTER
    AMMON PECK; Fiscal Year: 1999
    ..it can cause numerous pathological conditions, including hyperoxaluria, cardiac conductance disorders, calcium oxalate stones, renal failure, death and possibly inflammatory bowel disease and vulvovestibulitis...
  13. REGULATION OF ENTERIC HYPEROXALURI BY OXALOBACTER
    AMMON PECK; Fiscal Year: 2000
    ..it can cause numerous pathological conditions, including hyperoxaluria, cardiac conductance disorders, calcium oxalate stones, renal failure, death and possibly inflammatory bowel disease and vulvovestibulitis...
  14. Nutritional Impact of Modifying Calcium Partitioning
    Kendal Hirschi; Fiscal Year: 2005
    ..Eventually, the application of the approaches used here may be used to fortify various staple crops to erode the gap between calcium intake and requirements. ..
  15. Nutritional Impact of Modifying Calcium Partitioning
    Kendal Hirschi; Fiscal Year: 2004
    ..Eventually, the application of the approaches used here may be used to fortify various staple crops to erode the gap between calcium intake and requirements. ..
  16. ENZYMES IN ANIMAL METABOLISM OF OXALATE DERIVATIVES
    Gordon Hamilton; Fiscal Year: 1990
    ..in animals, it may aid in our understanding of the reasons for the development of kidney stones due to calcium oxalate. Finally, if oxalyl derivatives are found to be intermediates in ascorbate catabolism, it will clarify ..
  17. Nutritional Impact of Modifying Calcium Partitioning
    Kendal Hirschi; Fiscal Year: 2007
    ..Eventually, the application of the approaches used here may be used to fortify various staple crops to erode the gap between calcium intake and requirements. [unreadable] [unreadable]..
  18. Nutritional Impact of Modifying Calcium Partitioning
    Kendal Hirschi; Fiscal Year: 2006
    ..Eventually, the application of the approaches used here may be used to fortify various staple crops to erode the gap between calcium intake and requirements. [unreadable] [unreadable]..
  19. Hyperoxaluria and Tubule Injury and Kidney Stone Disease
    Neil Mandel; Fiscal Year: 2003
    ..We propose that the pig is ideal for the development of an animal model of calcium oxalate crystalluria and calcium oxalate stone disease...
  20. Hyperoxaluria Leading to Tubule Injury and Kidney Stone Disease
    Neil Mandel; Fiscal Year: 2004
    ..We propose that the pig is ideal for the development of an animal model of calcium oxalate crystalluria and calcium oxalate stone disease...
  21. Treatment of Calcium Nephrolithiasis Sodium Thiosulfate
    John Asplin; Fiscal Year: 2006
    ..The aims of this proposal are to determine if sodium thiosulfate can reduce calcium oxalate and calcium phosphate stone formation and/or reduce urine crystallization potential in hypercalciuric kidney ..
  22. Oxalobacter as a therapy in IBD-associated urolithiasis
    AMMON PECK; Fiscal Year: 2005
    ..the gut has been shown to correlate with hyperoxaluria and an increased frequency of first-time and recurrent calcium oxalate kidney stones; consequently, the absence of O. formigenes appears to be a risk factor for urolithiasis...
  23. Oxalobacter as a therapy in IBD-associated urolithiasis
    AMMON PECK; Fiscal Year: 2006
    ..the gut has been shown to correlate with hyperoxaluria and an increased frequency of first-time and recurrent calcium oxalate kidney stones; consequently, the absence of O. formigenes appears to be a risk factor for urolithiasis...
  24. Effect of Pyridoxamine in Oxalate excretion in Stone Disease and Hyperoxaluria
    Jon Scheinman; Fiscal Year: 2006
    ..Most stones are made of calcium oxalate (CaOx), and urinary oxalate is a major risk factor...
  25. NOVEL INHIBITOR OF CRYSTAL ADHESION TO RENAL CELLS
    JOHN LIESKE; Fiscal Year: 1999
    ..My studies during the past 8 years demonstrate that calcium oxalate monohydrate (COM) crystals bind within seconds to anionic, sialic acid- containing glycoproteins on the ..
  26. NOVEL INHIBITOR OF CRYSTAL ADHESION TO RENAL CELLS
    JOHN LIESKE; Fiscal Year: 2000
    ..My studies during the past 8 years demonstrate that calcium oxalate monohydrate (COM) crystals bind within seconds to anionic, sialic acid- containing glycoproteins on the ..
  27. OXALIC ACID METABOLISM AND PRIMARY HYPEROXALURIA
    Keith Richardson; Fiscal Year: 1980
    ..and the development of effective procedures for the prevention and treatment of primary hyperoxaluria, kidney calcium oxalate stones, and ethylene glycol toxicity...
  28. The Effect of Gastric Bypass Surgery on Renal Function and Metabolism
    Benjamin K Canales; Fiscal Year: 2010
    ..glomerular, interstitial, and papillary cells are chronically exposed to high amounts of oxalate and/or calcium oxalate crystals, leading to the production of reactive oxygen species, oxidative stress, renal injury, and ..
  29. HISTOPATHOLOGIC DETERMINANTS OF HUMAN NEPHROLITHIASIS
    Andrew Evan; Fiscal Year: 2005
    ..the histopathological and mineral composition in three groups of stone formers: common idiopathic calcium oxalate stone formers, patients with stones due to intestinal bypass surgery for obesity and brushite stone formers (..
  30. HISTOPATHOLOGIC DETERMINANTS OF HUMAN NEPHROLITHIASIS
    Andrew Evan; Fiscal Year: 2006
    ..the histopathological and mineral composition in three groups of stone formers: common idiopathic calcium oxalate stone formers, patients with stones due to intestinal bypass surgery for obesity and brushite stone formers (..
  31. Diagnosis of Crystalopathies via Raman Spectroscopy
    Ozan Akkus; Fiscal Year: 2005
    ..urate, calcium pyrophosphate dihydrate, hydroxyapatite, octacalcium phosphate, tricalcium phosphate, calcium oxalate, cholesterol, cystine and xanthine will be mixed with healthy synovial fluid samples at various ..
  32. HISTOPATHOLOGIC DETERMINANTS OF HUMAN NEPHROLITHIASIS
    Andrew Evan; Fiscal Year: 2007
    ..the histopathological and mineral composition in three groups of stone formers: common idiopathic calcium oxalate stone formers, patients with stones due to intestinal bypass surgery for obesity and brushite stone formers (..
  33. Diagnosis of Crystalopathies via Raman Spectroscopy
    Ozan Akkus; Fiscal Year: 2006
    ..urate, calcium pyrophosphate dihydrate, hydroxyapatite, octacalcium phosphate, tricalcium phosphate, calcium oxalate, cholesterol, cystine and xanthine will be mixed with healthy synovial fluid samples at various ..
  34. CALCIUM OXALATE IN BIOLOGICAL SYSTEMS
    ROSS HOLMES; Fiscal Year: 1999
    ..Such scientists will include plant biologists who investigate the orderly formation of calcium oxalate crystals of precise shape in specialized plant cells, microbiologists who examine the ability of ..
  35. Biochemical Studies of Oxalate Decarboxylase
    NIGEL GORDON JOHN RICHARDS; Fiscal Year: 2010
    ..and so OxDC has the potential for clinical use in treating urolithiasis and/or preventing the formation of calcium oxalate-based stones...
  36. DIET SALT, CALCIUM KIDNEY STONES, BONE IN STONE FORMERS
    Linda Massey; Fiscal Year: 2001
    ..Thirty-two subjects with a history of at least one calcium oxalate kidney stone will be recruited; 16 with hypercalciuria, 16 normocalciuria...
  37. Use of symbiotics to reduce urinary oxalate excretion
    JOHN LIESKE; Fiscal Year: 2006
    ..Furthermore, the formation of calcium oxalate kidney stones is extremely common, and evidence suggests that minimal, perhaps transient elevations in ..
  38. Urolithiasis: Oxalate Interactions with the Renal Cells
    Hari K Koul; Fiscal Year: 2010
    ..Thus this proposed study completely satisfies the requirements set forth in the Program Announcement. ..
  39. Genetic Linkages in Calcium Oxalate Stone Disease
    Neil Mandel; Fiscal Year: 2005
    ..To date, the only well-defined genetic abnormalities leading to hyperoxaluria and calcium oxalate stone disease have been described for primary and secondary hyperoxaluria and associated with specific enzyme ..
  40. Use of symbiotics to reduce urinary oxalate excretion
    JOHN LIESKE; Fiscal Year: 2005
    ..Furthermore, the formation of calcium oxalate kidney stones is extremely common, and evidence suggests that minimal, perhaps transient elevations in ..
  41. Urolithiasis: Oxalate Interactions with the Renal Cells
    Hari K Koul; Fiscal Year: 2010
    ..Thus this proposed study completely satisfies the requirements set forth in the Program Announcement. ..
  42. Genetic Linkages in Calcium Oxalate Stone Disease
    Neil Mandel; Fiscal Year: 2004
    ..To date, the only well-defined genetic abnormalities leading to hyperoxaluria and calcium oxalate stone disease have been described for primary and secondary hyperoxaluria and associated with specific enzyme ..
  43. ENZYME-COATED URINARY PROSTHESES TO PREVENT ENCRUSTATION
    STEPHEN BARTELMEZ; Fiscal Year: 2004
    ....
  44. Genetic Linkages in Calcium Oxalate Stone Disease
    Neil Mandel; Fiscal Year: 2007
    ..To date, the only well-defined genetic abnormalities leading to hyperoxaluria and calcium oxalate stone disease have been described for primary and secondary hyperoxaluria and associated with specific enzyme ..
  45. Genetic Linkages in Calcium Oxalate Stone Disease
    Neil Mandel; Fiscal Year: 2003
    ..To date, the only well-defined genetic abnormalities leading to hyperoxaluria and calcium oxalate stone disease have been described for primary and secondary hyperoxaluria and associated with specific enzyme ..
  46. ENZYME-COATED URINARY PROSTHESES TO PREVENT ENCRUSTATION
    Harmeet Sidhu; Fiscal Year: 2003
    ....
  47. Urolithiasis: Oxalate Interactions with the Renal Cells
    Hari Koul; Fiscal Year: 2009
    ..Thus this proposed study completely satisfies the requirements set forth in the Program Announcement. ..
  48. Genetic Linkages in Calcium Oxalate Stone Disease
    Neil Mandel; Fiscal Year: 2006
    ..To date, the only well-defined genetic abnormalities leading to hyperoxaluria and calcium oxalate stone disease have been described for primary and secondary hyperoxaluria and associated with specific enzyme ..
  49. GENERAL CLINICAL RESEARCH CENTER
    CHARLES GINSBURG; Fiscal Year: 2006
    ..abstract_text> ..
  50. CRYSTAL INTERACTIONS IN RENAL STONE DISEASE
    Neil Mandel; Fiscal Year: 1993
    ..have been subjected to established protocols which induce specific forms of cellular injury shown to enhance calcium oxalate stone formation...
  51. CRYSTAL INTERACTIONS IN RENAL STONE DISEASE
    Neil Mandel; Fiscal Year: 1992
    ..have been subjected to established protocols which induce specific forms of cellular injury shown to enhance calcium oxalate stone formation...
  52. CALCIUM-OXALATE INTERATION IN MODULATING CALCIUM OXALATE STONE FORMATION
    Margaret Pearle; Fiscal Year: 2007
    ..in urinary calcium associated with calcium supplementation, minimizing the change in urinary saturation of calcium oxalate. In this 2-phase randomized crossover trial comprised of placebo and calcium carbonate phases, 10 normal ..
  53. Oxalate Reduction by Oral Administration of Oxalate Degrading Enzymes
    Qingshan Li; Fiscal Year: 2010
    ..High concentrations of oxalate and deposition of calcium oxalate (CaOx) crystals in the kidneys can evoke an inflammatory response and induce tubulointerstitial damage ..
  54. BIOPHYSICS OF URINARY STONE DISEASE
    Raymond Hackett; Fiscal Year: 1990
    ..Project 1 deals with physical chemical problems relevant to urolithiasis, primarily of calcium oxalate and especially its surface chemistry...
  55. THE KINETICS OF FORMATION OF RENAL STONES
    GEORGE NANCOLLAS; Fiscal Year: 1980
    ..characterization of the kinetics of growth and dissolution of synthetic renal stone-forming minerals such as calcium oxalate, uric acid, the urates, calcium phosphates and magnesium ammonium phosphate in supersaturated solutions and ..
  56. Endogenous Oxalate Synthesis
    ROSS HOLMES; Fiscal Year: 2006
    ..Endogenous oxalate synthesis may also play a role in idiopathic calcium oxalate nephrolithiasis and decreasing the amount synthesized could be an effective therapeutic strategy...
  57. Endogenous Oxalate Synthesis
    ROSS HOLMES; Fiscal Year: 2007
    ..Endogenous oxalate synthesis may also play a role in idiopathic calcium oxalate nephrolithiasis and decreasing the amount synthesized could be an effective therapeutic strategy...
  58. Endogenous Oxalate Synthesis
    ROSS HOLMES; Fiscal Year: 2009
    ..Endogenous oxalate synthesis may also play a role in idiopathic calcium oxalate nephrolithiasis and decreasing the amount synthesized could be an effective therapeutic strategy...
  59. CRYSTAL INTERACTIONS IN RENAL STONE DISEASE
    Neil Mandel; Fiscal Year: 2002
    ..will be limited to the four most common crystalline components of human urinary tract stones, namely calcium oxalate monohydrate (COM) and calcium oxalate dihydrate (COD), basic calcium phosphate (apatite, AP), and uric acid (..
  60. Dietary Oxalate and Kidney Stone Formation
    Dean Assimos; Fiscal Year: 2007
    ..The bulk of these stones consist primarily of calcium oxalate. The amount of calcium and oxalate in urine are thus significant risk factors for the disease...
  61. CRYSTAL INTERACTIONS IN RENAL STONE DISEASE
    Neil Mandel; Fiscal Year: 2005
    ..will be limited to the four most common crystalline components of human urinary tract stones, namely calcium oxalate monohydrate (COM) and calcium oxalate dihydrate (COD), basic calcium phosphate (apatite, AP), and uric acid (..
  62. CRYSTAL INTERACTIONS IN RENAL STONE DISEASE
    Neil Mandel; Fiscal Year: 2004
    ..will be limited to the four most common crystalline components of human urinary tract stones, namely calcium oxalate monohydrate (COM) and calcium oxalate dihydrate (COD), basic calcium phosphate (apatite, AP), and uric acid (..
  63. CRYSTAL INTERACTIONS IN RENAL STONE DISEASE
    Neil Mandel; Fiscal Year: 2003
    ..will be limited to the four most common crystalline components of human urinary tract stones, namely calcium oxalate monohydrate (COM) and calcium oxalate dihydrate (COD), basic calcium phosphate (apatite, AP), and uric acid (..
  64. UROLITHIASIS AND PEROXIDATIVE INJURY
    Sivagnanam Thamilselvan; Fiscal Year: 2000
    ..39 billion dollars/year. About two thirds of the stones contain calcium oxalate. Chances of recurrences within 10 years are nearly 60 percent...
  65. UROLITHIASIS AND PEROXIDATIVE INJURY
    Sivagnanam Thamilselvan; Fiscal Year: 1999
    ..39 billion dollars/year. About two thirds of the stones contain calcium oxalate. Chances of recurrences within 10 years are nearly 60 percent...
  66. Oxalate-Induced Renal Scarring and Crystal Retention
    JOHN LIESKE; Fiscal Year: 2002
    ..Furthermore, calcium oxalate kidney stone formation is extremely common in the general population, and evidence suggests that minimal, ..
  67. UROLITHIASIS AND PEROXIDATIVE INJURY
    Sivagnanam Thamilselvan; Fiscal Year: 2001
    ..39 billion dollars/year. About two thirds of the stones contain calcium oxalate. Chances of recurrences within 10 years are nearly 60 percent...
  68. D-GLYCERATE DEHYDROGENASE AND PRIMARY HYPEROXALURIA
    ROSS HOLMES; Fiscal Year: 2000
    ..that occurs in this disease can result in kidney failure and premature death due to the tissue deposition of calcium oxalate crystals...
  69. D-GLYCERATE DEHYDROGENASE AND PRIMARY HYPEROXALURIA
    ROSS HOLMES; Fiscal Year: 2001
    ..that occurs in this disease can result in kidney failure and premature death due to the tissue deposition of calcium oxalate crystals...
  70. D-GLYCERATE DEHYDROGENASE AND PRIMARY HYPEROXALURIA
    ROSS HOLMES; Fiscal Year: 1999
    ..that occurs in this disease can result in kidney failure and premature death due to the tissue deposition of calcium oxalate crystals...
  71. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2010
    Hyperoxaluria is considered a major risk factor in the genesis of calcium oxalate stone disease which occurs in about 12% of the U. S. population costing an estimated $2 billion annually...
  72. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2007
    Hyperoxaluria is considered a major risk factor in the genesis of calcium oxalate stone disease which occurs in about 12% of the U. S. population costing an estimated $2 billion annually...
  73. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2010
    Hyperoxaluria is considered a major risk factor in the genesis of calcium oxalate stone disease which occurs in about 12% of the U. S. population costing an estimated $2 billion annually...
  74. DIGESTION OF FOOD OXALATE
    Harmeet Sidhu; Fiscal Year: 2000
    ..to the amount of oxalate excreted in urine and thus plays an important role in the development of calcium oxalate kidney stones...
  75. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2009
    Hyperoxaluria is considered a major risk factor in the genesis of calcium oxalate stone disease which occurs in about 12% of the U. S. population costing an estimated $2 billion annually...