malonates

Summary

Top Publications

  1. ncbi The brain tissue response to biodegradable poly(methylidene malonate 2.1.2)-based microspheres in the rat
    Elvire Fournier
    Inserm U646 Ingénierie de la vectorisation particulaire, 10 rue André Bocquel, 49 100 Angers, France
    Biomaterials 27:4963-74. 2006
  2. pmc Lewis acid-catalyzed conjugate additions of silyloxyallenes: a selective solution to the intermolecular Rauhut-Currier problem
    Troy E Reynolds
    Department of Chemistry, Northwestern University, Evanston, IL 60208, USA
    Org Lett 10:2449-52. 2008
  3. pmc MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula
    Jian Zhao
    Plant Biology Division, Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401, USA
    Plant Cell 23:1536-55. 2011
  4. pmc Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington's disease: role of CB1 and CB2 receptors
    Sara Valdeolivas
    Departamento de Bioquimica y Biologia Molecular, Instituto Universitario de Investigación en Neuroquímica, Centro deInvestigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, and Instituto Ramón y Cajal deInvestigación Sanitaria IRYCIS, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    ACS Chem Neurosci 3:400-6. 2012
  5. pmc Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease
    Sylvie Toulmond
    Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Quebec, H9H 3L1, Canada
    Br J Pharmacol 141:689-97. 2004
  6. ncbi Palladium-catalyzed arylation of malonates and cyanoesters using sterically hindered trialkyl- and ferrocenyldialkylphosphine ligands
    Neil A Beare
    Department of Chemistry, Yale University, P O Box 208107, New Haven, Connecticut 06520 8107, USA
    J Org Chem 67:541-55. 2002
  7. ncbi Characterization of novel astragaloside malonates from Radix Astragali by HPLC with ESI quadrupole TOF MS
    Chu Chu
    Key Laboratory of Modern Chinese Medicines China Pharmaceutical University, Ministry of Education, Nanjing, P R China
    J Sep Sci 33:570-81. 2010
  8. ncbi Photo-induced damages of cytoplasmic and mitochondrial membranes by a [C60]fullerene malonic acid derivative
    Xinlin Yang
    School of Life Science and Technology, Beijing Institute of Technology, Beijing, China
    Int J Toxicol 26:197-201. 2007
  9. ncbi Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application
    Yu Sam Kim
    Department of Biochemistry, College of Science, Protein Network Research Center, Yonsei University, Seoul 120 749, Korea
    J Biochem Mol Biol 35:443-51. 2002
  10. ncbi Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate
    Isabel Lastres-Becker
    URA CEA CNRS 2210, Service Hospitalier Frederic Joliot, DRM, DSV, CEA, 4 Place du General Leclerc, 91401 Orsay Cedex, France
    Neuroreport 14:813-6. 2003

Research Grants

Detail Information

Publications212 found, 100 shown here

  1. ncbi The brain tissue response to biodegradable poly(methylidene malonate 2.1.2)-based microspheres in the rat
    Elvire Fournier
    Inserm U646 Ingénierie de la vectorisation particulaire, 10 rue André Bocquel, 49 100 Angers, France
    Biomaterials 27:4963-74. 2006
    ..PMM 2.1.2 was thus shown to be inadequate for intracerebral drug delivery...
  2. pmc Lewis acid-catalyzed conjugate additions of silyloxyallenes: a selective solution to the intermolecular Rauhut-Currier problem
    Troy E Reynolds
    Department of Chemistry, Northwestern University, Evanston, IL 60208, USA
    Org Lett 10:2449-52. 2008
    ..These latent allenolates undergo conjugate additions to alkylidene malonates in the presence of 10 mol % Sc(OTf) 3...
  3. pmc MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula
    Jian Zhao
    Plant Biology Division, Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401, USA
    Plant Cell 23:1536-55. 2011
    ..However, some flavonoid glycoside malonates accumulate to higher levels in MATE2 knockouts than in wild-type controls...
  4. pmc Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington's disease: role of CB1 and CB2 receptors
    Sara Valdeolivas
    Departamento de Bioquimica y Biologia Molecular, Instituto Universitario de Investigación en Neuroquímica, Centro deInvestigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, and Instituto Ramón y Cajal deInvestigación Sanitaria IRYCIS, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    ACS Chem Neurosci 3:400-6. 2012
    ....
  5. pmc Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease
    Sylvie Toulmond
    Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Quebec, H9H 3L1, Canada
    Br J Pharmacol 141:689-97. 2004
    ..5. These data provide in vivo proof-of-concept of the neuroprotective effects of reversible caspase-3 inhibitors in a model of malonate-induced striatal injury in the adult rat...
  6. ncbi Palladium-catalyzed arylation of malonates and cyanoesters using sterically hindered trialkyl- and ferrocenyldialkylphosphine ligands
    Neil A Beare
    Department of Chemistry, Yale University, P O Box 208107, New Haven, Connecticut 06520 8107, USA
    J Org Chem 67:541-55. 2002
    ..reactions of aryl bromides and chlorides with two common stabilized carbanions-enolates of dialkyl malonates and alkyl cyanoesters-are reported...
  7. ncbi Characterization of novel astragaloside malonates from Radix Astragali by HPLC with ESI quadrupole TOF MS
    Chu Chu
    Key Laboratory of Modern Chinese Medicines China Pharmaceutical University, Ministry of Education, Nanjing, P R China
    J Sep Sci 33:570-81. 2010
    ..With the strategy of target precursor ions scan, a total of 22 astragalosides including 8 astragaloside malonates were screened and characterized from the methanolic extract of Radix Astragali by HPLC-Q-TOF/MS...
  8. ncbi Photo-induced damages of cytoplasmic and mitochondrial membranes by a [C60]fullerene malonic acid derivative
    Xinlin Yang
    School of Life Science and Technology, Beijing Institute of Technology, Beijing, China
    Int J Toxicol 26:197-201. 2007
    ..These data provided some novel clues to explain the mechanisms involved in the photo-induced cytotoxicity of fullerene derivatives...
  9. ncbi Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application
    Yu Sam Kim
    Department of Biochemistry, College of Science, Protein Network Research Center, Yonsei University, Seoul 120 749, Korea
    J Biochem Mol Biol 35:443-51. 2002
    ..In addition to these, the genes matB and matC have been successfully used for generation of the industrial strain of Streptomyces for the production of antibiotics...
  10. ncbi Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate
    Isabel Lastres-Becker
    URA CEA CNRS 2210, Service Hospitalier Frederic Joliot, DRM, DSV, CEA, 4 Place du General Leclerc, 91401 Orsay Cedex, France
    Neuroreport 14:813-6. 2003
    ....
  11. ncbi SmI(2)-mediated carbon-carbon bond fragmentation in alpha-aminomethyl malonates
    Qiongfeng Xu
    The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xue Yuan Road, Beijing 100083, China
    Org Lett 11:4136-8. 2009
    A new and efficient samarium diiodide-promoted carbon-carbon bond fragmentation reaction of alpha-aminomethyl malonates, taking place normally at room temperature and generating the corresponding deaminomethylation products in 74-94% ..
  12. ncbi Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli
    S Hoenke
    Mikrobiologisches Institut der Eidgenössischen Technischen Hochschule, Zurich, Switzerland
    Eur J Biochem 246:530-8. 1997
    ..As partial deletion of the mdcR gene impaired growth of the transformants on malonate, MdcR is probably a transcriptional regulator of the mdc genes...
  13. pmc Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: relevance for Huntington's disease
    Onintza Sagredo
    Departamento de Bioquímica y Biología Molecular and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Glia 57:1154-67. 2009
    ..Altogether, our results support the hypothesis that CB2 receptors could constitute a therapeutic target to slowdown neurodegeneration in HD...
  14. ncbi Enzymic and genetic basis for bacterial growth on malonate
    P Dimroth
    Mikrobiologisches Institut, Eidgenossische Technische Hochschule, ETH Zentrum, Zurich, Switzerland
    Mol Microbiol 25:3-10. 1997
    ..The genetic evidence firmly supports the idea that malonate decarboxylation is carried out by the two different decarboxylases, as deduced from the biochemical studies of the enzymes...
  15. pmc Detection and quantification of glycosylated flavonoid malonates in celery, Chinese celery, and celery seed by LC-DAD-ESI/MS
    Long Ze Lin
    Food Composition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, 103000 Baltimore Avenue, Beltsville, MD 20705, USA
    J Agric Food Chem 55:1321-6. 2007
    ..derivatives was confirmed by their conversion into glycosides upon heating and by comparison of some of the malonates with malonates that had previously been identified in red bell pepper and parsley...
  16. ncbi Pd(II)-catalyzed asymmetric addition of malonates to dihydroisoquinolines
    Naoki Sasamoto
    IMRAM, Tohoku University, Miyagi 980 8577, Japan
    J Am Chem Soc 128:14010-1. 2006
    We have developed a highly efficient reaction for catalytic asymmetric addition of malonates to dihydroisoquinolines using chiral Pd(II) complexes...
  17. ncbi Nucleocytoplasmic-localized acyltransferases catalyze the malonylation of 7-O-glycosidic (iso)flavones in Medicago truncatula
    Xiao Hong Yu
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Plant J 55:382-96. 2008
    ..Such C-terminal polypeptide deletion or deletion of the DFGWG motif alone led to improper folding of the transiently expressed GFP fusion protein in living cells, and impaired nuclear localization of the enzyme...
  18. ncbi Inhibitory effects of KAT-681, a liver-selective thyromimetic, on development of hepatocellular proliferative lesions in rats induced by 2-acetylaminofluorene and partial hepatectomy after diethylnitrosamine initiation
    Morimichi Hayashi
    Toxicology Laboratories, Research and Development, Kissei Pharmaceutical Co Ltd, 2320 1 Maki, Hotaka, Minamiazumi gun, 399 8305 Nagano, Japan
    Arch Toxicol 78:460-6. 2004
    ..25 mg/kg per day KAT (by 64%). The results of the present study thus suggest that KAT inhibits the development of altered hepatocellular foci and might be a promising chemopreventive agent for hepatocarcinogenesis...
  19. ncbi Palladium-catalyzed carbonylation-decarboxylation of diethyl(2-iodoaryl)malonates with imidoyl chlorides: an efficient route to substituted isoquinolin-1(2H)-ones
    Zhaoyan Zheng
    Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada
    Org Lett 10:4903-6. 2008
    ..were synthesized in reasonable to good yields by the palladium-catalyzed cyclization of diethyl(2-iodoaryl)malonates with imidoyl chlorides and carbon monoxide in tetrahydrofuran...
  20. pmc The thyromimetic T-0681 protects from atherosclerosis
    Ivan Tancevski
    Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    J Lipid Res 50:938-44. 2009
    ..Our data suggest that liver-selective thyromimetics, such as T-0681, may prove to be useful therapeutic agents against the development of atherosclerosis in humans...
  21. ncbi Nephrotoxicity of heptaplatin: a randomized comparison with cisplatin in advanced gastric cancer
    Jin Hee Ahn
    Section of Hematology Oncology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 138 736, Korea
    Cancer Chemother Pharmacol 50:104-10. 2002
    ..Heptaplatin is a newly developed platinum derivative which has been reported to be less toxic than cisplatin. This study was designed to evaluate the nephrotoxicity of heptaplatin in comparison with that of cisplatin...
  22. ncbi Mitochondrial toxin inhibition of [(3)H]dopamine uptake into rat striatal synaptosomes
    William F Maragos
    Department of Neurology, Kentucky Clinic, Room L 445, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Biochem Pharmacol 63:1499-505. 2002
    ..e. noncompetitive inhibition of the DAT...
  23. ncbi Urea- and thiourea-substituted cinchona alkaloid derivatives as highly efficient bifunctional organocatalysts for the asymmetric addition of malonate to nitroalkenes: inversion of configuration at C9 dramatically improves catalyst performance
    Séamus H McCooey
    Centre for Synthesis and Chemical Biology, Department of Chemistry, Trinity College, University of Dublin, Dublin 2, Ireland
    Angew Chem Int Ed Engl 44:6367-70. 2005
  24. ncbi Geminal dicarboxylates as carbonyl surrogates for asymmetric synthesis. Part II. Scope and applications
    B M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    J Am Chem Soc 123:3687-96. 2001
    ..In conjunction with the subsequent reactions that occur with high stereospecificity, allylic gem-dicarboxylates serve as synthons for a double allylic transformation...
  25. ncbi Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter
    Lily Y Moy
    Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Pharmacol Exp Ther 320:747-56. 2007
    ....
  26. ncbi Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively
    Peter D Alfinito
    Levine Neuroscience Laboratory, Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 23:10982-7. 2003
    ..Interestingly, these effects are mediated by A1 and A2a receptors located in the substantia nigra for DAergic neurons and in the striatum for GABAergic neurons...
  27. ncbi Striatal damage and oxidative stress induced by the mitochondrial toxin malonate are reduced in clorgyline-treated rats and MAO-A deficient mice
    William F Maragos
    University of Kentucky, Department of Neurology, USA
    Neurochem Res 29:741-6. 2004
    ..These findings indicate that normal levels of MAO-A participate in expression of malonate toxicity by a mechanism involving oxidative stress...
  28. ncbi Enhancement of 3,4-methylenedioxymethamphetamine neurotoxicity by the energy inhibitor malonate
    W L Nixdorf
    Program in Basic and Clinical Neuroscience, Department of Psychiatry, Case Western Reserve University, Cleveland, USA
    J Neurochem 77:647-54. 2001
    ..Overall, these results highlight the importance of energy balance to the function of DA and 5-HT neurons and to the toxic effects of MDMA...
  29. pmc Mechanisms of the interaction of nitroxyl with mitochondria
    Sruti Shiva
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochem J 379:359-66. 2004
    ....
  30. ncbi Organocatalytic conjugate addition of malonates to alpha,beta-unsaturated aldehydes: asymmetric formal synthesis of (-)-paroxetine, chiral lactams, and lactones
    Sven Brandau
    The Danish National Research Foundation Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark
    Angew Chem Int Ed Engl 45:4305-9. 2006
  31. ncbi Ternary phase diagram for the Belousov-Zhabotinsky reaction-induced mechanical oscillation of intelligent PNIPAM colloids
    Jingyi Shen
    Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, Texas 77843, USA
    J Phys Chem A 111:12081-5. 2007
    ....
  32. ncbi Practical synthesis of optically active alpha,alpha-disubstituted malonamic acids through asymmetric hydrolysis of malonamide derivatives with Rhodococcus sp. CGMCC 0497
    Zhong Liu Wu
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China
    J Org Chem 68:2479-82. 2003
    ..The enantioselectivity originated from the effects of a highly enantioselective amidase. The products could be converted to valuable (R)- or (S)-alpha,alpha-dialkylated amino acids after routine conversions...
  33. ncbi Enantioselective modular synthesis of 2,4-disubstituted cyclopentenones by iridium-catalyzed allylic alkylation
    Mathias Schelwies
    Organisch Chemisches Institut der Universitat Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany
    Angew Chem Int Ed Engl 45:2466-9. 2006
  34. doi Strontium-catalyzed highly enantioselective Michael additions of malonates to enones
    Magno Agostinho
    Department of Chemistry, School of Science, The University of Tokyo, The HFRE Division, ERATO, JST, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Am Chem Soc 130:2430-1. 2008
  35. ncbi Desymmetrization-like catalytic enantioselective fluorination of malonates and its application to pharmaceutically attractive molecules
    Dhande Sudhakar Reddy
    Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa Ku, Nagoya 466 8555, Japan
    Angew Chem Int Ed Engl 47:164-8. 2008
  36. ncbi Organocatalytic asymmetric total synthesis of (R)-rolipram and formal synthesis of (3S,4R)-paroxetine
    Peter S Hynes
    School of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom
    Org Lett 10:1389-91. 2008
    ....
  37. ncbi Manganese(III)-catalyzed free radical reactions on trimetallic nitride endohedral metallofullerenes
    Chunying Shu
    Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060 0212, USA
    J Am Chem Soc 129:15710-7. 2007
    ..These are the highest levels of substitution of TNT metallofullerenes reported so far...
  38. ncbi Neurodegeneration in methylmalonic aciduria involves inhibition of complex II and the tricarboxylic acid cycle, and synergistically acting excitotoxicity
    Jürgen G Okun
    Department of Pediatrics, Division of Metabolic and Endocrine Diseases, Im Neuenheimer Feld 150, Federal Republic of Germany
    J Biol Chem 277:14674-80. 2002
    ..We propose that neuropathogenesis of methylmalonic aciduria may involve an inhibition of complex II and the tricarboxylic acid cycle by accumulating toxic organic acids, and synergistic secondary excitotoxic mechanisms...
  39. ncbi N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury
    C Demougeot
    , Laboratoire de Pharmacodynamie, , Dijon, France Service de Neurologie, Centre Hospitalier Universitaire, Dijon, France
    J Neurochem 77:408-15. 2001
    ..Overall results show that cellular dysfunction can cause higher reductions in NAA level than neuronal loss, thus making of NAA quantification a potential tool for visualizing the penumbra area in stroke patients...
  40. ncbi Spectrophotometric study of fluorescence sensing and selective binding of biochemical substrates by 2,2'-bridged bis(beta-cyclodextrin) and its water-soluble fullerene conjugate
    Yu Liu
    Department of Chemistry, State Key Laboratory of Elemento organic Chemistry, Nankai University, Tianjin 300071, P R China
    J Phys Chem B 109:23739-44. 2005
    ....
  41. ncbi Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline
    Sylvie Cornet
    Ipsen Institut Henri Beaufour, 5 Avenue du Canada, 91966 Les Ulis, France
    Eur J Pharmacol 505:111-9. 2004
    ..From these experiments, the neuroprotective activity of minocycline appears more related to its antiinflammatory activity than to a direct beneficial action on mitochondria...
  42. ncbi A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo
    Lichuan Yang
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
    Neurobiol Dis 17:250-9. 2004
    ..These findings suggest that systematically active broad-spectrum caspase inhibitors maybe useful in the treatment of neurodegenerative diseases such as PD and HD...
  43. ncbi Neuroprotective effects mediated by dopamine receptor agonists against malonate-induced lesion in the rat striatum
    R Fancellu
    Laboratory of Functional Neurochemistry, IRCCS C Mondino, Pavia, Italy
    Neurol Sci 24:180-1. 2003
    ..Our data suggest that malonate- induced striatal toxicity can be attenuated by systemic administration of dopamine agonists, with D1 and D2 agonists showing different profiles of efficacy...
  44. ncbi Role of corticostriatal and nigrostriatal inputs in malonate-induced striatal toxicity
    A Meldrum
    Centre for Brain Repair, Cambridge University, UK
    Neuroreport 12:89-93. 2001
    ..These data suggest that malonate-induced toxicity in the striatum depends upon the integrity of interactive influences from both glutamatergic and dopaminergic afferents...
  45. ncbi Time course of oxidative stress, lesion and edema after intrastriatal injection of malonate in rat: effect of alpha-phenyl-N-tert-butylnitrone
    Alexia Paucard
    Laboratoire de Pharmacologie, UPRES EA2510, Universite Rene Descartes, 4 avenue de l Observatoire, 75006 Paris, France
    Fundam Clin Pharmacol 19:57-64. 2005
    ..Taken together, these results show that malonate induced a severe oxidative stress leading to the rapid development of the lesion. PBN demonstrates anti-edematous properties that are not sufficient to reduce the lesion...
  46. ncbi Biphasic modulation by nitric oxide of caspase activation due to malonate injection in rat striatum
    Alexia Paucard
    Laboratoire de Pharmacologie, Universite Rene Descartes, 4 avenue de l Observatoire, 75006 Paris, France
    Eur J Pharmacol 483:259-65. 2004
    ..Thus NO production by the neuronal isoform of NO-synthase is not the major event leading to caspase activation due to malonate. However, NO seems to have pro- and anti-caspase effects that neutralize each other...
  47. ncbi Dopamine receptor agonists mediate neuroprotection in malonate-induced striatal lesion in the rat
    Marie Therese Armentero
    Laboratory of Functional Neurochemistry, IRCCS, C Mondino, Pavia, Italy
    Exp Neurol 178:301-5. 2002
    ..Our data suggest that malonate-induced striatal toxicity can be attenuated by systemic administration of dopamine agonists, with D(1) and D(2) agonists showing different profiles of efficacy...
  48. ncbi Mitochondrial permeability transition in neuronal damage promoted by Ca2+ and respiratory chain complex II inhibition
    Evelise N Maciel
    Departamento de Patologia Clinica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, Brazil
    J Neurochem 90:1025-35. 2004
    ..We propose that under conditions in which mitochondrial complex II is partially inhibited in the CNS, neuronal cell death involves the induction of PT...
  49. ncbi Methylmalonate inhibits succinate-supported oxygen consumption by interfering with mitochondrial succinate uptake
    S R Mirandola
    Departamento de Patologia Clinica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP 13083 887, Brazil
    J Inherit Metab Dis 31:44-54. 2008
    ....
  50. ncbi Effect of oxygen on activation state of complex I and lack of oxaloacetate inhibition of complex II in Langendorff perfused rat heart
    Elena Maklashina
    Molecular Biology Division, VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    FEBS Lett 556:64-8. 2004
    ..In addition, these studies show that complex II is fully active in the mitochondrion and not inhibited by OAA regardless of the oxygen concentration...
  51. pmc The endogenous mitochondrial complex II inhibitor malonate regulates mitochondrial ATP-sensitive potassium channels: implications for ischemic preconditioning
    Andrew P Wojtovich
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochim Biophys Acta 1777:882-9. 2008
    ..Together, these observations suggest that complex II inhibition by endogenously formed malonate may represent an important activation pathway for mK(ATP) channels during IPC...
  52. ncbi Cooperative interaction between ascorbate and glutathione during mitochondrial impairment in mesencephalic cultures
    Julie Ehrhart
    Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    J Neurochem 86:1487-97. 2003
    ..It is speculated that these events are linked by glutaredoxin, an enzyme shown to contain both dehydroascorbate reductase as well as glutathione thioltransferase activities...
  53. ncbi Geminal dicarboxylates as carbonyl surrogates for asymmetric synthesis. Part I. Asymmetric addition of malonate nucleophiles
    B M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 123:3671-86. 2001
    Asymmetric alkylations of allylic geminal dicarboxylates with dialkyl malonates have been investigated...
  54. ncbi 3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors
    Alexey Rivkin
    Department of Chemistry, Merck Research Laboratories, Boston, MA 02115, USA
    Bioorg Med Chem Lett 16:4620-3. 2006
    ..Starting from a derivative with an IC(50) = 1.4 microM, SAR studies led to compounds with more than 70-fold increase in potency (IC(50) < 20 nM)...
  55. ncbi Catalytic relationships between type I and type II iterative polyketide synthases: The Aspergillus parasiticus norsolorinic acid synthase
    Yue Ma
    School of Chemistry, University of Bristol, Cantock s Close, Clifton, Bristol, BS8 1TS, UK
    Chembiochem 7:1951-8. 2006
    ..The NSAS holo-ACP was also active in actinorhodin minimal PKS assays, but only in the presence of exogenous malonyl transferases...
  56. ncbi Improved reagent for electrophilic amination of stabilized carbanions
    Jason A Smulik
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Org Lett 5:4187-90. 2003
    ..Reagent 2 reacts efficiently with stabilized sodium or potassium enolates derived from malonates, phenylacetates, and phenylacetonitriles and is sufficiently soluble for use in solution at -78 degrees C.
  57. ncbi The decarboxylative Blaise reaction
    Jae Hoon Lee
    Chemical Development Division, LG Life Sciences, Ltd R and D, 104 1 Moonji dong, Yusong gu, Daejeon 305 380, Korea
    J Org Chem 72:10261-3. 2007
    ..Compared to the classical Blaise reaction, this reaction is safer (endothermic), devoid of lacrimatory reagent, and is possible with 0.5-1.0 equiv of zinc chloride...
  58. ncbi Quantitating the effect of an ortho substituent on cyclization and intramolecular hydrogen-transfer reactions of aryl radicals
    Dennis P Curran
    Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Org Chem 68:2972-4. 2003
    Reduction of allyl 2-iodobenzyl malonates with triphenyltin hydrides generates aryl radicals that partition between 6-exo cyclization, 7-endo cyclization, and 1,5-hydrogen atom transfer...
  59. ncbi Zn(II)/amine-catalyzed coupling reaction of alkylidenemalonates with propargyl alcohol: a one-pot synthesis of methylenetetrahydrofurans
    Masaharu Nakamura
    Department of Chemistry, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Org Lett 6:2015-7. 2004
    ..In the presence of catalytic amounts of zinc triflate [Zn(OTf)(2)] and triethylamine (Et(3)N), various 2-alkylidene-1,3-dicarbonyl compounds reacted with propargyl alcohol to give 3- or 4-methylene tetrahydrofurans in excellent yields...
  60. ncbi Synthesis of indenes by the transition metal-mediated carboannulation of alkynes
    Daohua Zhang
    Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA
    J Org Chem 72:251-62. 2007
    ..The third method involves intermolecular palladium-catalyzed arylation of the arylalkynes formed in the first step of the second method...
  61. ncbi Boc-protected amines via a mild and efficient one-pot Curtius rearrangement
    Hélène Lebel
    Departement de Chimie, Universite de Montreal, P O Box 6128, Station Downtown, Montreal, Quebec, Canada H3C 3J7
    Org Lett 7:4107-10. 2005
    ..These reaction conditions are compatible with a variety of substrates, including malonate derivatives, which provide access to protected amino acids...
  62. ncbi Conformations, energies, and intramolecular hydrogen bonds in dicarboxylic acids: implications for the design of synthetic dicarboxylic acid receptors
    Thanh Ha Nguyen
    Faculty of Pharmacy, University of Sydney, NSW 2006, Australia
    J Comput Chem 26:1233-41. 2005
    ..Intramolecular H-bond redshifts of 170-250 cm(-1) have been estimated from the results of the harmonic frequency analyses...
  63. ncbi A convenient method for the efficient removal of ruthenium byproducts generated during olefin metathesis reactions
    Y M Ahn
    Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66044, USA
    Org Lett 3:1411-3. 2001
    ..Treatment of the crude reaction products with triphenylphosphine oxide or dimethyl sulfoxide, followed by filtration through silica gel, was found to be a practical and effective method to remove colored ruthenium byproducts...
  64. ncbi ESI-MS studies on the mechanism of Pd0-catalyzed three-component tandem double addition-cyclization reaction
    Hao Guo
    State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P R China
    J Am Chem Soc 127:13060-4. 2005
    ..characterized by the high-resolution ESI-FTMS technology, on the basis of which a mechanism was proposed for the Pd0-catalyzed three-component tandem double addition cyclization of organic halides, 2-(2,3-allenyl)malonates, and imines.
  65. pmc Efficient removal of ruthenium byproducts from olefin metathesis products by simple aqueous extraction
    Soon Hyeok Hong
    The Arnold and Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Org Lett 9:1955-7. 2007
    ..Simple aqueous extraction removed ruthenium byproducts efficiently from ring-closing metathesis (RCM) reactions catalyzed by a poly(ethylene glycol) (PEG) supported N-heterocyclic carbene-based ruthenium complex...
  66. ncbi Novel autoxidation and Michael addition of a butenolide-containing sugar leading to a C-branched-chain glucopyranosidulose, and X-ray structure of intermediates
    Hong Min Liu
    Department of Chemistry, Zhengzhou University, Daxue Road, Zhengzhou 450052, PR China
    Carbohydr Res 338:1737-43. 2003
    ..The autoxidations are also performed in weakly basic, neutral and weakly acidic medium, respectively...
  67. ncbi Michael addition of ortho-lithiated aryloxiranes to alpha,beta-unsaturated malonates: synthesis of tetrahydroindenofuranones
    Antonio Salomone
    Dipartimento Farmaco Chimico, Universita di Bari, Consorzio Interuniversitario Nazionale Metodologie e Processi Innovativi di Sintesi, Via E Orabona 4, I 70125 Bari, Italy
    Org Lett 10:1947-50. 2008
    ..of tetrahydroindenofuranones based on the Michael addition of ortho-lithiated aryloxiranes to alkylidene malonates followed by the nucleophilic oxirane ring-opening and subsequent lactonization is described...
  68. ncbi Enantioselective syntheses of tremulenediol A and tremulenolide A
    Brandon L Ashfeld
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA
    Org Lett 7:4535-7. 2005
    ..This strategy was applied to the first enantioselective syntheses of tremulenediol A and tremulenolide A...
  69. ncbi Regioselective tandem dimethylsulfonium methylide addition-eliminative olefination of diendioates: a novel route to 1,3-butadien-2-ylmalonates
    Rekha Singh
    Bio Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
    Org Lett 9:5071-4. 2007
    ....
  70. ncbi Convenient syntheses and transformations of 2-C-malonyl carbohydrates
    Jian Yin
    Department of Chemistry, University of Potsdam, Karl Liebknecht Strasse 24 25, 14476 Potsdam, Germany
    Chemistry 13:10152-67. 2007
    2-C-malonyl carbohydrates were synthesized in only few steps and high yields by radical additions of malonates to glycals...
  71. ncbi gem-Dibromomethylarenes: a convenient substitute for noncommercial aldehydes in the knoevenagel-doebner reaction for the synthesis of alpha,beta-unsaturated carboxylic acids
    John Kallikat Augustine
    Syngene International Ltd, Biocon Park, Plot Nos 2 and 3, Bommasandra IV Phase, Jigani Link Road, Bangalore 560 100, India
    J Org Chem 72:9854-6. 2007
    ..gem-Dibromomethylarenes are employed for the first time in the Knoevenagel-Doebner reaction as aldehyde equivalents for the efficient synthesis of alpha,beta-unsaturated carboxylic acids...
  72. ncbi A practical synthesis of (+/-)-alpha-isosparteine from a tetraoxobispidine core
    Paul R Blakemore
    Department of Chemistry, Oregon State University, Corvallis, Oregon 97331 4003, USA
    Org Lett 7:4721-4. 2005
    ..Tetraoxobispidine 7 was itself prepared in three simple operations from dimethyl malonate. The entire sequence to alpha-isosparteine was conducted on a multigram scale and proceeded without recourse to chromatography...
  73. ncbi Preparation of pyrrolidine-based PDE4 inhibitors via enantioselective conjugate addition of alpha-substituted malonates to aromatic nitroalkenes
    Paul J Nichols
    Department of Process Chemistry Research, Array BioPharma, 3200 Walnut Street, Boulder, Colorado 80301, USA
    Org Lett 8:1495-8. 2006
    reaction: see text] The enantioselective conjugate addition of alpha-substituted malonates to aromatic nitroalkenes generates a stereocenter at the carbon bearing the aromatic group and an adjacent prochiral center from the alpha-..
  74. ncbi LC/UV/ESI-MS analysis of isoflavones in Edamame and Tofu soybeans
    Qingli Wu
    New Use Agriculture and Natural Plant Products Program, Department of Plant Biology and Pathology, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, New Jersey, USA
    J Agric Food Chem 52:2763-9. 2004
    ..a total 16 isoflavones, including three aglycones, three glycosides, two glycoside acetates, and eight glycoside malonates. The major isoflavones in soybean seeds were daidzein and genistein glycoside and their malonate conjugates...
  75. ncbi Determination of isoflavones in red clover and related species by high-performance liquid chromatography combined with ultraviolet and mass spectrometric detection
    Qingli Wu
    New Use Agriculture and Natural Plant Products Program, Department of Plant Biology and Pathology, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901, USA
    J Chromatogr A 1016:195-209. 2003
    ..The separated isoflavones including aglycones, glycosides and glycoside malonates, were individually analyzed and identified by their molecular ions and characteristic fragment ion peaks using ..
  76. ncbi Flavonoids in Leguminosae: analysis of extracts of T. pratense L., T. dubium L., T. repens L., and L. corniculatus L. leaves using liquid chromatography with UV, mass spectrometric and fluorescence detection
    Eva de Rijke
    Department of Analytical Chemistry and Applied Spectroscopy, Free University, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    Anal Bioanal Chem 378:995-1006. 2004
    ..In T. pratense and T. repens, the main constituents were flavonoid glucoside-(di)malonates, while T. dubium and L. corniculatus mainly contained flavonoid (di)glycosides...
  77. ncbi Variation in the composition of the essential oils, phenolic compounds and mineral elements of Hypericum perforatum L. growing in Estonia
    Kati Helmja
    Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia
    Nat Prod Res 25:496-510. 2011
    ..to the earlier published polyphenols, several new phenolic acids and flavonoids, such as quercetin hexoside malonates and an A-type catechin-epicatechin trimer were identified in this Hypericum for the first time...
  78. ncbi Phosphoramidites are efficient, green organocatalysts for the Michael reaction. Mechanistic insights into the phosphorus-catalyzed Michael reaction of alkynones and implications for asymmetric catalysis
    Robert B Grossman
    Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506 0055, USA
    J Org Chem 68:871-4. 2003
    ..phosphites have been found to be efficient catalysts for the Michael reaction of alkenones and alkynones with malonates, alpha-cyano esters, beta-keto esters, and nitro compounds...
  79. ncbi LC-ESI-MS study of the flavonoid glycoside malonates of red clover (Trifolium pratense)
    L Z Lin
    Research Laboratory of Natural Products Chemistry, A M Todd Botanicals, Eugene, Oregon 97402, USA
    J Agric Food Chem 48:354-65. 2000
    ..ionization-mass spectrometry (LC-ESI-MS) was applied to the analysis of the flavonoids and their glycoside malonates of the flowers and leaves of red clover (Trifolium pratense)...
  80. ncbi Phenolic compounds and chromatographic profiles of pear skins (Pyrus spp.)
    Long Ze Lin
    Food Composition and Methods Development Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, Beltsville, Maryland 20705 3000, USA
    J Agric Food Chem 56:9094-101. 2008
    ..Peckham, Red, Red D'Anjou, and Seckel) contained significant quantities of isorhamnetin glycosides and their malonates and lesser quantities of quercetin glycosides...
  81. ncbi Enantioselective Friedel-Crafts alkylation of indoles with trifluoroethylidene malonates by copper-bis(oxazoline) complexes: construction of trifluoromethyl-substituted stereogenic tertiary carbon center
    Lele Wen
    Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Rd, Shanghai, 200032, China
    J Org Chem 76:2282-5. 2011
    An enantioselective alkylation of indoles with trifluoroethylidene malonates catalyzed by copper(II)-bis (oxazoline) complexes has been developed...
  82. ncbi Catalytic asymmetric ring-opening of meso-aziridines with malonates under heterodinuclear rare earth metal Schiff base catalysis
    Yingjie Xu
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Am Chem Soc 133:5791-3. 2011
    Catalytic asymmetric ring-opening of meso-aziridines with malonates is described. The combined use of two rare earth metal sources with different properties promoted the desired ring-opening reaction...
  83. ncbi Mechanistic studies on the catalytic asymmetric Mannich-type reaction with dihydroisoquinolines and development of oxidative Mannich-type reactions starting from tetrahydroisoquinolines
    Christian Dubs
    Synthetic Organic Chemistry Laboratory, RIKEN 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Org Chem 73:5859-71. 2008
    Detailed mechanistic studies on our recently reported asymmetric addition reactions of malonates to dihydroisoquinolines (DHIQs) catalyzed by chiral Pd(II) complexes were carried out...
  84. ncbi Enantioselective and regioselective organocatalytic conjugate addition of malonates to nitroenynes
    Xiao Jiao Li
    Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091 China
    Chem Asian J 6:220-5. 2011
    ..Notably, the protocol worked well with both aryl- and alkyl-substituted alkynyl substrates...
  85. ncbi Asymmetric electrophilic amination of various carbon nucleophiles with enantiomerically pure chiral N-h oxaziridines derived from camphor and fenchone
    Philip C Bulman Page
    Department of Chemistry, Loughborough University, Leicestershire LE11 3TU, England
    J Org Chem 67:7787-96. 2002
    ..Nitrogen is transferred, together with the camphor/fenchone unit, when deprotonated esters, malonates, and nitriles are used as nucleophiles...
  86. ncbi Lewis Base-Promoted Hydrosilylation of Cyclic Malonates: Synthesis of beta-Substituted Aldehydes and gamma-Substituted Amines
    Christopher G Frost
    Department of Chemistry, University of Bath, Bath, BA2 7AY, United Kingdom
    J Org Chem 74:3599-602. 2009
    The Lewis base-promoted hydrosilylation of cyclic malonates provides a convenient synthesis of beta-substituted aldehydes...
  87. ncbi Ytterbium-catalyzed conjugate allylation of alkylidene malonates
    Charlene Fallan
    EaStCHEM, School of Chemistry, University of Edinburgh, Joseph Black Building, The King s Buildings, West Mains Road, Edinburgh, EH9 3JJ, United Kingdom
    J Org Chem 76:4112-8. 2011
    Alkylidene malonates undergo efficient conjugate allylation upon treatment with allylstannanes or allylsilanes under the action of ytterbium catalysis.
  88. ncbi High-performance liquid chromatography (HPLC) analysis of phenolic compounds in berries with diode array and electrospray ionization mass spectrometric (MS) detection: ribes species
    Kaisu R Määttä
    Institute of Applied Biotechnology and Food and Health Research Centre, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    J Agric Food Chem 51:6736-44. 2003
    ..However, cyanidin 3-O-sambubioside and quercetin hexoside-malonate were notable phenolic compounds in red currant. Flavonol hexoside-malonates were identified and quantified in the berries of currants for the first time.
  89. ncbi Stereoselective synthesis of 2-carbamoyl-2-cyanocyclopropanecarboxylates by tandem oxidative cyclization and neighboring group-assisted decarboxylation
    Hua Wang
    Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China
    J Org Chem 75:6994-7. 2010
    ..neighboring group-assisted decarboxylation of the Michael adducts of 2-cyanoacetamides with α,β-unsaturated malonates. This method affords the desired highly functionalized cyclopropanes in moderate to good yields and with ..
  90. ncbi Synthesis of new C2- symmetric fluoren-9-ylidene malonate derived bis(oxazoline) ligands and their application in Friedel-Crafts reactions
    Jing Li
    Department of Applied Chemistry, China Agricultural University, Beijing 100193, China
    Molecules 15:8582-92. 2010
    ..Their asymmetric catalytic properties in the Friedel-Crafts reactions of indoles with arylidene malonates were evaluated, and the Cu(OTf)2 complex of a fluoren-9-ylidene malonate-derived bis(oxazoline) bearing a phenyl ..
  91. ncbi A new reactivity pattern for vinyl bromides: cine-substitution via palladium catalysed C-N coupling/Michael addition reactions
    Michael C Willis
    Department of Chemistry, University of Bath, Bath BA2 7AY, UK
    Org Biomol Chem 3:3094-5. 2005
    ..can be used to convert vinyl bromides to the corresponding enamines, which are reacted in situ with alkylidene malonates to provide Michael adducts. The overall transformation results in cine-substitution of the starting vinyl bromide...
  92. ncbi Synthesis and anti-tumor activity of novel ethyl 3-aryl-4-oxo-3,3a,4,6-tetrahydro-1H-furo[3,4-c]pyran-3a-carboxylates
    Tiantian Wang
    Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China
    Bioorg Med Chem Lett 21:3381-3. 2011
    ..were prepared through the metal-catalyzed domino reaction of alkylidene malonates and 1,4-butynediol under a one-pot reaction condition at room temperature...
  93. ncbi Highly enantioselective synthesis of α,α-dialkylmalonates by phase-transfer catalytic desymmetrization
    Suckchang Hong
    Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    J Am Chem Soc 133:4924-9. 2011
    A novel enantioselective synthetic method for the construction of a quaternary carbon center from malonates via phase-transfer catalytic (PTC) alkylation has been developed...
  94. ncbi Hydrogen bond directed highly regioselective palladium-catalyzed allylic substitution
    Gregory R Cook
    Department of Chemistry, North Dakota State University, Fargo, North Dakota 58105 5516, USA
    J Am Chem Soc 125:5115-20. 2003
    ..to be directed to the internal carbon (branched:linear, 75:25 to >98:2), whereas sulfonamides, amines, and malonates added only to the terminal carbon of the allyl complex...
  95. ncbi Water-compatible iminium activation: highly enantioselective organocatalytic Michael addition of malonates to α,β-unsaturated enones
    Zhifeng Mao
    Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000 China
    J Org Chem 75:7428-30. 2010
    The highly enantioselective Michael addition of malonates to α,β-unsaturated ketones in water was reported to be catalyzed by a primary-secondary diamine catalyst containing a long alkyl chain...
  96. ncbi Enantioselective organocatalytic Michael addition of aldehydes to trifluoroethylidene malonates
    Lele Wen
    Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, PRC
    Org Lett 12:4655-7. 2010
    ..highly enantioselective, organocatalytic Michael addition reaction of aldehydes with trifluoroethylidene malonates is described...
  97. ncbi Development of microwave assisted extraction for the simultaneous determination of isoflavonoids and saponins in radix astragali by high performance liquid chromatography
    Jing Zheng Song
    Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, Hong Kong, China
    J Sep Sci 30:819-24. 2007
    ..It was found that flavonoid glycoside malonates were converted into their related glycosides during the prolonged conventional extraction, thus affecting the ..
  98. ncbi Highly enantioselective Michael addition of malonates to beta,gamma-unsaturated alpha-ketoesters catalyzed by chiral N,N'-dioxide-Yttrium(III) complexes with convenient procedure
    Lin Zhou
    Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China
    Chem Commun (Camb) 46:3601-3. 2010
    Highly enantioselective Michael addition of malonates to beta,gamma-unsaturated alpha-ketoesters has been promoted by chiral N,N'-dioxide-Yttrium(iii) complexes, providing the corresponding products in excellent yields with 94-99% ee ..
  99. ncbi Palladium-catalyzed cyclocarbonylation-decarboxylation of diethyl(2-iodoaryl)malonates with vinyl ketones affording functionalized enolic 2-acyl-3,4-dihydronaphthalenones
    Zhaoyan Zheng
    Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada
    Org Lett 11:3278-81. 2009
    ..moderate to excellent yields by the palladium-catalyzed cyclocarbonylation-decarboxylation of diethyl(2-iodoaryl)malonates with vinyl ketones and carbon monoxide...
  100. ncbi Tandem photocycloaddition-retro-mannich fragmentation of enaminones. A route to spiropyrrolines and the tetracyclic core of koumine
    James D White
    Department of Chemistry, Oregon State University, Corvallis, Oregon 97331 4003, USA
    Org Lett 8:1081-4. 2006
    reaction: see text] Intramolecular [2 + 2] photocycloaddition of beta-aminoalkylidene malonates gives transiently a cyclobutane which undergoes retro-Mannich fragmentation to a Delta(1)-pyrroline...
  101. ncbi Asymmetric three- and [2 + 1]-component conjugate addition reactions for the stereoselective synthesis of polysubstituted piperidinones
    Stephen G Davies
    Department of Organic Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK
    Org Biomol Chem 5:1405-15. 2007
    ..Asymmetric three-component couplings of alpha,beta-unsaturated esters and alkylidene malonates initiated by lithium amide conjugate addition proceeds with high levels of 2,3-anti stereoselectivity, with ..

Research Grants28

  1. Dopamine Toxicity in Models of Huntington's Disease
    William Maragos; Fiscal Year: 2004
    ..The results of these studies will demonstrate the critical role that metabolism of dopamine plays in striatal neuron death in Huntington's disease and offer a potentially novel therapeutic approach for the treatment of this disorder. ..
  2. METHAMPHETAMINE AND HIV PROTEIN-INDUCED NEUROTOXICITY
    William Maragos; Fiscal Year: 2005
    ..To accomplish these goals, we will assess the effects of intrastriatal injections of virotoxins in animals treated with methamphetamine and in vitro in human cortical neurons where cell types can be manipulated. ..
  3. Economical Soy Isoflavone Production
    J Weber; Fiscal Year: 2004
    ..This should raise production levels of isoflavones to commercially useful levels. In addition/other bacterial fermentations will be investigated for the production of new biologically active isoflavone metabolites. ..
  4. ASYMMETRIC SYNTHESIS OF IONOPHORE/MACROLIDE ANTIBIOTICS
    David Evans; Fiscal Year: 2005
    ..Our goal has been to set in place all of the reactions necessary for the rapid assemblage of any polyketide target structure. ..
  5. ALTERNATIVE MECHANISMS OF UGA CODON RECOGNITION
    Marla Berry; Fiscal Year: 2005
    ..Continuing studies of this process will surely unveil new and exciting information about the complex workings of the translation machinery. ..
  6. Antibiotic Gene Clusters
    J Weber; Fiscal Year: 2005
    ..In Phase II we are proposing to apply this new basic knowledge to the development of modern methods of strain improvement for erythromycin and other important drugs. ..
  7. Industrial Metabolic Engineering
    J Weber; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  8. SELENOPROTEIN P FUNCTION AND REGULATION OF EXPRESSION
    Marla Berry; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  9. ENERGY METABOLISM, DOPAMINE NEURONS AND NEUROTOXICITY
    Gail Zeevalk; Fiscal Year: 2008
    ..The studies will have relevance to neurodegenerative conditions or pathophysiological situations in which metabolism is compromised. ..
  10. ASYMMETRIC SYNTHESIS OF VANCOMYCIN ANTIBIOTICS
    David Evans; Fiscal Year: 2001
    ..During the course of this project we intend to confirm (correct) the absolute stereochemical assignments of the principal members of this family by total synthesis. ..
  11. Novel Macrolide and Ketolide Antibiotic Intermediates
    J Weber; Fiscal Year: 2003
    ..In addition, a new macrolide biosynthetic gene cluster will be cloned and its gene sequenced obtained in part, to identify new biotailoring enzymes for future work in Phase II. ..
  12. Industrial Metabolic Engineering
    J Weber; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. Metabolic engineering of the methylmalonyl-CoA node in S. erythrea
    J Weber; Fiscal Year: 2007
    ..The technology that will be developed in this project will elucidate path- ways leading to the biosynthesis of commercially important antibiotics with a focus on erythromycin. [unreadable] [unreadable] [unreadable]..
  14. Engineering metabolic flow for rapamycin production
    J Weber; Fiscal Year: 2005
    ..This will be the first test of this technology for a drug other than erythromycin, and will help to establish the general applicability of the strategy for strain improvement. ..
  15. Synthesis of Polyketides and Terpenes
    David A Evans; Fiscal Year: 2010
    ..As a consequence, organic synthesis is a critical discipline that continues to have an important impact on the fields of both medicine and biology. ..
  16. Canine Multiple System Degeneration: A Novel Animal Model of Parkinsonism
    DENNIS O BRIEN; Fiscal Year: 2008
    ..This research will develop a novel animal model of the disease which can be used to test theories about the cause and develop new therapies. [unreadable] [unreadable] [unreadable]..
  17. Purchase of a 600 MHz NMR Spectrometer with Cryoprobe
    DENNIS CURRAN; Fiscal Year: 2007
    ..This research often requires sophisticated NMR experiments on small samples, and the requested 600 MHz spectrometer will greatly expedite ongoing and planned work. [unreadable] [unreadable] [unreadable]..
  18. RADICAL REACTIONS FOR NATURAL PRODUCTS
    DENNIS CURRAN; Fiscal Year: 2002
    ....
  19. TRANSITION METAL CATALYZED C-C BONDING FORMING REACTION
    JAMES TAKACS; Fiscal Year: 2002
    ..Each application is designed to push the limits of the metal-mediated cyclization methodology, and as such will require targeted developmental work to be successful. ..
  20. Excitotoxic Signaling in HD Transgenic Neurons
    KARI HOYT; Fiscal Year: 2004
    ..The cell culture models of HD proposed in this work should also provide a convenient means for testing relevant therapies for HD. ..
  21. STRUCTURE OF VIRAL RNA AND ITS ROLE IN ASSEMBLY
    Alexander McPherson; Fiscal Year: 2006
    ..This research is significant because the conformation of the nucleic acid component of no virus is currently known, nor is there any comprehensive structural basis for the processes of viral assembly and disassembly. ..
  22. FLUOROUS METHODS FOR TRADITIONAL AND PARALLEL SYNTHESIS
    DENNIS CURRAN; Fiscal Year: 2003
    ..In short, the work will help to move the very young field of fluorous chemistry from infancy into childhood. ..
  23. MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLS
    Lawrence Lash; Fiscal Year: 2007
    ..Achievement of these aims should build on our previous work in human kidney cells and extend it to provide a much more complete understanding of the various and complex ways in which DCVC affects the human kidney [unreadable] [unreadable]..
  24. Carbon Antioxidants to Prevent Diabetic Complications
    MICHAEL DIENER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  25. Self-Assembled Solutions to Asymmetric Hydrogenation
    JAMES TAKACS; Fiscal Year: 2005
    ....
  26. Molecular Cages for Alpha Particle Radioimmunotherapy
    MICHAEL DIENER; Fiscal Year: 2002
    ..The development of such a therapy has a potential market of approximately 300,000 Americans/yr. ..
  27. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 2003
    ..This information may have therapeutic applications for prevention of renal cellular injury or for understanding mitochondrial diseases or age-related decreases that occur in mitochondrial function. ..
  28. Carbon Antioxidants To Prevent Atherosclerosis
    MICHAEL DIENER; Fiscal Year: 2003
    ..This project will study whether carbon-based antioxidants can extend their success to LDL protection and confer their benefits in vivo for retarding atherosclerosis. ..