Genomes and Genes
Summary: Acetic acid and its derivatives which may be formed by substitution reactions. Mono- and di-substituted, as well as halogenated compounds have been synthesized.
Publications234 found, 100 shown here
- Rat pachytene spermatocytes down-regulate a polo-like kinase and up-regulate a thiol-specific antioxidant protein, whereas sertoli cells down-regulate a phosphodiesterase and up-regulate an oxidative stress protein after exposure to methoxyethanol and metV Syed
Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
Endocrinology 139:3503-11. 1998....
- COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertilityD X Xie
School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
Science 280:1091-4. 1998..It has similarity to the F-box proteins Arabidopsis TIR1, human Skp2, and yeast Grr1, which appear to function by targeting repressor proteins for removal by ubiquitination...
- Cytoplasmic alkalization precedes reactive oxygen species production during methyl jasmonate- and abscisic acid-induced stomatal closureDontamala Suhita
CEA Cadarache DSV DEVM, Laboratoire des Echanges Membranaires et Signalisation, UMR 163 CNRS CEA, Universite de la Mediterranee, 13108 St Paul lez Durance Cedex, France
Plant Physiol 134:1536-45. 2004..Our results further indicate that JAR1, as OST1, functions upstream of ROS produced by NAD(P)H oxidases and that the cytoplasmic alkalization precedes ROS production during MJ or ABA signal transduction in guard cells...
- Bacterial protection of beetle-fungus mutualismJarrod J Scott
Department of Bacteriology, University of Wisconsin Madison, WI 53706, USA
Science 322:63. 2008....
- Selective activation of thyroid hormone signaling pathways by GC-1: a new approach to controlling cholesterol and body weightJohn D Baxter
Diabetes Center and Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0540, USA
Trends Endocrinol Metab 15:154-7. 2004..Although more study is required, compounds of this class deserve further investigation for treating lipid disorders and obesity...
- The coronatine-insensitive 1 mutation reveals the hormonal signaling interaction between abscisic acid and methyl jasmonate in Arabidopsis guard cells. Specific impairment of ion channel activation and second messenger productionShintaro Munemasa
Graduate School of Natural Science and Technology, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
Plant Physiol 143:1398-407. 2007....
- Transcriptional profiling of sorghum induced by methyl jasmonate, salicylic acid, and aminocyclopropane carboxylic acid reveals cooperative regulation and novel gene responsesRon A Salzman
Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
Plant Physiol 138:352-68. 2005....
- Exogenous application of methyl jasmonate elicits defenses in Norway spruce (Picea abies) and reduces host colonization by the bark beetle Ips typographusNadir Erbilgin
Division of Insect Biology Department of Environmental Science, Policy and Management University of California, 140 Mulford Hall, Berkeley, CA, 94720, USA
Oecologia 148:426-36. 2006..The increased amount of terpenoid resin present in methyl jasmonate-treated bark could be directly responsible for the observed decrease in I. typographus colonization and reproduction...
- Bromochloroacetic acid exerts qualitative effects on rat sperm: implications for a novel biomarkerGary R Klinefelter
U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 72, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 68:164-73. 2002..84. Using this exposure paradigm, the no-observed-effect level for BCA is less than 8 mg/kg. Moreover, SP22 may be useful in predicting compromised fertility after exposure to by-products of drinking water disinfection...
- The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseusHongtao Zhang
Institute of Biology, Leiden University, Sylvius Laboratory, PO Box 9505, 2300 RA Leiden, The Netherlands
Plant J 67:61-71. 2011....
- Myrosinases, TGG1 and TGG2, redundantly function in ABA and MeJA signaling in Arabidopsis guard cellsMohammad Mahbub Islam
Graduate School of Natural Science and Technology, Okayama University, 3 1 1 Tsushima naka, Okayama, Japan
Plant Cell Physiol 50:1171-5. 2009..A model is discussed in which two myrosinases redundantly function downstream of ROS production and upstream of cytosolic Ca(2+) elevation in ABA and MeJA signaling in guard cells...
- Expression profiling reveals COI1 to be a key regulator of genes involved in wound- and methyl jasmonate-induced secondary metabolism, defence, and hormone interactionsAlessandra Devoto
School of Biological Sciences, University of East Anglia, NR4 7TJ, Norwich, UK
Plant Mol Biol 58:497-513. 2005..These results indicate that COI1 plays a pivotal role in wound- and JA signalling...
- Jasmonates and Na-orthovanadate promote resveratrol production in Vitis vinifera cv. Barbera cell culturesAnnalisa Tassoni
Department of Biology e s and Interdepartmental Centre for Biotechnology, University of Bologna, Via Irnerio 42, 40126 Bologna, Italy
New Phytol 166:895-905. 2005..Gel analysis was performed on control and 10 microm MeJA treated cell suspensions. Results showed an up-regulation of the stilbene synthase demonstrating that MeJA stimulated the synthesis ex-novo of this protein...
- Comparisons of LIPOXYGENASE3- and JASMONATE-RESISTANT4/6-silenced plants reveal that jasmonic acid and jasmonic acid-amino acid conjugates play different roles in herbivore resistance of Nicotiana attenuataLei Wang
Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Jena, Germany
Plant Physiol 146:904-15. 2008....
- Laser microdissection of conifer stem tissues: isolation and analysis of high quality RNA, terpene synthase enzyme activity and terpenoid metabolites from resin ducts and cambial zone tissue of white spruce (Picea glauca)Eric Abbott
Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC, V6T 1Z4, Canada
BMC Plant Biol 10:106. 2010..These tissues are difficult to isolate for tissue-specific molecular and biochemical characterization and are thus good targets for application of LMD...
- Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronineGary J Grover
Metabolic and Cardiovascular Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey 08534, USA
Endocrinology 145:1656-61. 2004..Therefore, selective TRbeta activation may be a potentially usefully treatment for obesity and reduction of low density lipoprotein cholesterol and reduction of the atherogenic risk factor lipoprotein (a)...
- Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid miceLisen Johansson
Metabolism Unit, Center for Metabolism and Endocrinology, Department of Medicine, and Molecular Nutrition Unit, Center for Nutrition and Toxicology, Novum, Karolinska Institute at Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
Proc Natl Acad Sci U S A 102:10297-302. 2005..Use of TRbeta and uptake selective agonists such as GC-1 should be further explored as a strategy to improve lipid metabolism in dyslipoproteinemia...
- Toxicant-induced leakage of germ cell-specific proteins from seminiferous tubules in the rat: relationship to blood-testis barrier integrity and prospects for biomonitoringNaomi D Elkin
Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
Toxicol Sci 117:439-48. 2010....
- Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitmentNgoc Ha Nguyen
Program in Chemistry and Chemical Biology, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143 0446, USA
J Med Chem 45:3310-20. 2002..One mechanism for antagonism appears to be the ability of NH-3 to block TR-coactivator interactions. NH-3 will be a useful pharmacological tool for further study of T(3) signaling and TR function...
- Metabolic fate of jasmonates in tobacco bright yellow-2 cellsAgnieszka Swiatek
Laboratory of Plant Physiology and Biochemistry, Department of Biology, University of Antwerp, B 2610 Antwerp, Belgium
Plant Physiol 135:161-72. 2004..Upon hydrolysis of methyl jasmonate to jasmonic acid, a similar set of conversions occurs. In contrast to jasmonic acid, none of its derivatives interfere with the G2/M transition in synchronized tobacco Bright Yellow-2 cells...
- Biomonitoring of 2-(2-alkoxyethoxy)ethanols by analysing urinary 2-(2-alkoxyethoxy)acetic acidsJ Laitinen
Kuopio Regional Institute of Occupational Health, P O Box 93, FI 70701, Kuopio, Finland
Toxicol Lett 156:117-26. 2005..2-alkoxyethanols, and their most hazardous similarity is their ability to metabolize to the 2-(2-alkoxyethoxy)acetic acids. In the present study, floor lacquerers' (n = 22) inhalation and total exposure to 2-(2-alkoxy)ethoxyethanols ..
- Induction of larval tissue resorption in Xenopus laevis tadpoles by the thyroid hormone receptor agonist GC-1J David Furlow
Section of Neurobiology, Physiology, and Behavior, University of California, Davis, California 95616 8519, USA
J Biol Chem 279:26555-62. 2004..The effectiveness of GC-1 in inducing tail resorption and tail gene expression correlates with increasing TRbeta levels. These results illustrate the utility of subtype selective ligands as probes of nuclear receptor function in vivo...
- Cloning and expression of a tomato cDNA encoding a methyl jasmonate cleaving esteraseChristiane Stuhlfelder
Lehrstuhl fur Pharmazeutische Biologie, Julius von Sachs Institut fur Biowissenschaften, Universitat Wurzburg, Germany
Eur J Biochem 271:2976-83. 2004..Moreover, when tested in methyl jasmonate- and elicitor-treated cell suspension cultures, transcript levels were found to decrease, indicating that this particular enzyme might be a regulator of jasmonate signalling...
- Purification and partial amino acid sequences of an esterase from tomatoChristiane Stuhlfelder
Julius von Sachs Institute for Biosciences, Pharmaceutical Biology, University of Wurzburg, Julius von Sachs Platz 2, Germany
Phytochemistry 60:233-40. 2002..Sequence alignment of these fragments showed high homologies to certain plant esterases and hydroxynitrile lyases that belong to the alpha/beta hydrolase fold protein superfamily...
- Hormone selectivity in thyroid hormone receptorsR L Wagner
Department of Biochemistry, University of California, San Francisco, California 94143, USA
Mol Endocrinol 15:398-410. 2001..These results suggest a strategy for development of subtype-specific compounds involving modifications of the ligand at the 1-position...
- The thyroid hormone receptor beta-specific agonist GC-1 selectively affects the bone development of hypothyroid ratsFatima R S Freitas
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
J Bone Miner Res 20:294-304. 2005..Our findings indicate that T3 exerts some essential effects on bone development that are mediated by TRbeta1...
- A genomics approach to the early stages of triterpene saponin biosynthesis in Medicago truncatulaHideyuki Suzuki
Plant Biology Division, The Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
Plant J 32:1033-48. 2002..Sterol composition remained unaffected by jasmonate treatment. Molecular verification of induction of the triterpene pathway in a cell culture system provides a new tool for saponin pathway gene discovery by DNA array-based approaches...
- UV-C-irradiated Arabidopsis and tobacco emit volatiles that trigger genomic instability in neighboring plantsYouli Yao
Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada
Plant Cell 23:3842-52. 2011..Finally, various forms of stress resulting in the formation of necrotic lesions also generate a volatile signal that leads to genomic instability...
- Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirinStefano Fiorucci
Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
FASEB J 17:1171-3. 2003..These findings indicate that the balance between the production of LTB4 and ATL modulates PMN recruitment/function and gastric mucosal responses to aspirin...
- Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their estersYi Xia
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA
Bioorg Med Chem Lett 13:2891-3. 20032-Phenyl-4-quinolone acetic acids and their esters were synthesized and evaluated for interaction with tubulin and for cytotoxicity against a panel of human tumor cell lines...
- Methyl jasmonate does not induce changes in Eucalyptus grandis leaves that alter the effect of constitutive defences on larvae of a specialist herbivoreM L Henery
School of Botany and Zoology, The Australian National University, Canberra, NSW, 0200, Australia
Oecologia 156:847-59. 2008....
- Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activityMaxim Moreau
Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Quebec, Canada
J Rheumatol 33:1176-83. 2006..The effect of drug treatment on the expression and activity of metalloproteases in the OA cartilage was also studied...
- Sertoli cell modulates MAA-induced apoptosis of germ cells throughout voltage-operated calcium channelsFortunata Barone
Department of Histology and Medical Embryology, University of Rome La Sapienza, Via A Scarpa 14, 00161 Rome, Italy
FASEB J 18:353-4. 2004....
- N-acetylcysteine prevents MAA induced male germ cell apoptosis: role of glutathione and cytochrome cA V S Kondala Rao
National Institute of Immunology, Aruna Asaf Ali Marg, 110067, New Delhi, India
FEBS Lett 527:133-7. 2002..Replenishment of glutathione by pretreatment of the animals with the antioxidant N-acetylcysteine prior to MAA treatment could prevent the release of cytochrome c, DNA fragmentation and cell death...
- The laminin binding protein p40 is involved in inducing limb abnormality of mouse fetuses as the effects of methoxyacetic acid treatmentAceng Ruyani
Departemen Biologi, Institut Teknologi Bandung Jl, Ganesha No 10, Labtek XI, Bandung 40132, Indonesia
Toxicol Sci 75:148-53. 2003..The identity was further verified by Western blotting with an antibody against the 67 kDa LBP. The results suggest that MAA treatment to pregnant mice downregulates the LBP-p40 in the forelimb buds...
- A teratoproteomics analysis: heat shock protein 70 is upregulated in mouse forelimb bud by methoxyacetic acid treatmentAceng Ruyani
Program Studi Pendidikan Biologi, Universitas Bengkulu, Jalan Raya Kandang Limun, Bengkulu, Indonesia
Birth Defects Res A Clin Mol Teratol 73:517-21. 2005..Limb abnormalities are caused mainly by extensive cell death in the mesoderm of the limb plate. This investigation focused on identifying a protein that is linked with mouse limb teratogenicity...
- Activation of a stress-responsive mitogen-activated protein kinase cascade induces the biosynthesis of ethylene in plantsCha Young Kim
Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
Plant Cell 15:2707-18. 2003..These results suggest that the induction of ethylene but not JA/MJ is involved in plant defense responses mediated by the NtMEK2-SIPK/WIPK pathway...
- The short-chain fatty acid methoxyacetic acid disrupts endogenous estrogen receptor-alpha-mediated signalingDerek V Henley
Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 117:1702-6. 2009..The primary metabolite of EGME is methoxyacetic acid (MAA), a short-chain fatty acid that inhibits histone deacetylase activity and alters gene expression...
- High throughput sequencing technology reveals that the taxoid elicitor methyl jasmonate regulates microRNA expression in Chinese yew (Taxus chinensis)Deyou Qiu
Department of Molecular Biology, The Research Institute of Forestry, Chinese Academy of Forestry, Beijing, China
Gene 436:37-44. 2009....
- Transcription factor MYC2 is involved in priming for enhanced defense during rhizobacteria-induced systemic resistance in Arabidopsis thalianaMaria J Pozo
Graduate School Experimental Plant Sciences, Plant Microbe Interactions, Institute of Environmental Biology, Faculty of Science, Utrecht University, PO Box 800 56, 3508 TB, Utrecht, The Netherlands
New Phytol 180:511-23. 2008..Together, these results pinpoint MYC2 as a potential regulator in priming for enhanced JA-responsive gene expression during rhizobacteria-mediated ISR...
- A novel R2R3 MYB transcription factor NtMYBJS1 is a methyl jasmonate-dependent regulator of phenylpropanoid-conjugate biosynthesis in tobaccoIvan Galis
RIKEN Plant Science Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
Plant J 46:573-92. 2006....
- The jasmonate signal pathwayJohn G Turner
School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
Plant Cell 14:S153-64. 2002
- Arabidopsis vegetative storage protein is an anti-insect acid phosphataseYilin Liu
Department of Entomology, Texas A and M University, College Station, TX 77843, USA
Plant Physiol 139:1545-56. 2005..Collectively, we conclude that AtVSP2 is an anti-insect protein and that its defense function is correlated with its acid phosphatase activity...
- Overexpression of rice WRKY89 enhances ultraviolet B tolerance and disease resistance in rice plantsHaihua Wang
Department of Plant Pathology, State Key Laboratory of Agrobiotechnology, China Agricultural University, Yuanmenyuan West Rd 2, Beijing 100094, China
Plant Mol Biol 65:799-815. 2007..These results suggest that OsWRKY89 plays an important role in response to biotic and abiotic stresses...
- Multiple signalling pathways mediate fungal elicitor-induced beta-thujaplicin biosynthesis in Cupressus lusitanica cell culturesJian Zhao
Laboratory of Forest Biochemistry, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
J Exp Bot 54:647-56. 2003..These observations suggest that Ca(2+) and G-proteins may mediate elicitor signals to the jasmonate pathway, and the jasmonate signalling pathway may then lead to the production of beta-thujaplicin...
- Impact of methoxyacetic acid on mouse Leydig cell gene expressionGargi Bagchi
Division of Cell and Molecular Biology, Department of Biology, Boston University, Boston, MA 02215, USA
Reprod Biol Endocrinol 8:65. 2010..This study investigates the impact of MAA on gene expression in testicular Leydig cells, which play a critical role in germ cell survival and male reproductive function...
- Amide derivatives of [5-chloro-6-(2-chloro/fluorobenzoyl)-2-benzoxazolinone-3-yl]acetic acids as potential analgesic and anti-inflammatory compoundsErden Banoglu
Department of Pharmaceutical Chemistry, Division of Pharmaceutical Sciences, Faculty of Pharmacy, Gazi University, 06330 Etiler Ankara, Turkey
Arch Pharm (Weinheim) 336:251-7. 2003..of the carboxylate moiety into amides in [5-chloro-6-(2-chloro/fluorobenzoyl)-2-benzoxazolinone-3-yl]acetic acids. We have tested the analgesic and anti-inflammatory activities of the synthesized compounds in vivo by using p-..
- The influence of Ceratocystis polonica inoculation and methyl jasmonate application on terpene chemistry of Norway spruce, Picea abiesTao Zhao
Ecological Chemistry Group, Department of Chemistry, Royal Institute of Technology, SE 100 44 Stockholm, Sweden
Phytochemistry 71:1332-41. 2010..Thus, terpene composition in the stem bark may be related to resistance of Norway spruce against I. typographus and C. polonica...
- Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesisPatrick Marcouiller
Osteoarthritis Research Unit, Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec
J Rheumatol 32:704-12. 2005....
- Terpenoid biosynthesis and specialized vascular cells of conifer defenseKatherine G Zulak
Michael Smith Laboratories, University of British Columbia, Vancouver BC V6T 1Z4, Canada
J Integr Plant Biol 52:86-97. 2010..Formation of these resin ducts de novo in the cambium zone and developing xylem, following insect attack or treatment of trees with methyl jasmonate, is a unique feature of the induced defense of long-lived conifer trees...
- Methoxyacetic acid-induced spermatocyte death is associated with histone hyperacetylation in ratsMichael G Wade
Systemic Toxicology and Pharmacokinetics Section, Environmental Health Sciences Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada
Biol Reprod 78:822-31. 2008..Our results indicate that exposure to MAA causes increased acetylation of core histones in several testis germ cell populations, including those in prophase of meiosis, a large proportion of which die rapidly following this treatment...
- Roles of AtTPC1, vacuolar two pore channel 1, in Arabidopsis stomatal closureMohammad Mahbub Islam
Graduate School of Natural Science and Technology, Okayama University, 1 1 1 Tsushima naka, Okayama, 700 8530 Japan
Plant Cell Physiol 51:302-11. 2010....
- Insect-induced conifer defense. White pine weevil and methyl jasmonate induce traumatic resinosis, de novo formed volatile emissions, and accumulation of terpenoid synthase and putative octadecanoid pathway transcripts in Sitka spruceBarbara Miller
Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
Plant Physiol 137:369-82. 2005..Findings of insect- and MeJA-induced accumulation of allene oxide synthase-like and allene oxide cyclase-like transcripts are discussed in the context of traumatic resinosis and induced volatile emissions in this gymnosperm system...
- Impact of water stagnation in residential cold and hot water plumbing on concentrations of trihalomethanes and haloacetic acidsAnnick Dion-Fortier
Civil Engineering Department, Universite Laval, Quebec City, Canada G1K 7P4
Water Res 43:3057-66. 2009..The results are useful to identify methods of indoor water use that minimize population exposure to DBPs and improve DBP exposure assessment for epidemiological studies...
- Methyl jasmonate-elicited herbivore resistance: does MeJA function as a signal without being hydrolyzed to JA?Jinsong Wu
Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Hans Knoll Strasse 8, Jena, Germany
Planta 227:1161-8. 2008..From these results, we conclude that the resistance elicited by MeJA treatment is directly elicited not by MeJA but by its de-methylated product, JA...
- The effect of disinfection by-products and mutagenic activity on birth weight and gestational durationJ Michael Wright
Office of Research and Development, National Center for Environmental Assessment, U S Environmental Protection Agency, 26 W Martin Luther King Drive MS 90, Cincinnati, OH 45268, USA
Environ Health Perspect 112:920-5. 2004..These data also suggest a relationship between fetal development indices and mutagenic activity independent of exposure to trihalomethanes, haloacetic acids, and MX...
- Interactions of methoxyacetic acid with androgen receptorGargi Bagchi
Division of Cell and Molecular Biology, Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
Toxicol Appl Pharmacol 238:101-10. 2009..Deregulation of these genes may alter androgen synthesis and action in a manner that contributes to MAA-induced testicular toxicity...
- Metabolomics reveals novel pathways and differential mechanistic and elicitor-specific responses in phenylpropanoid and isoflavonoid biosynthesis in Medicago truncatula cell culturesMohamed A Farag
Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401, USA
Plant Physiol 146:387-402. 2008....
- Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension culturesY Yukimune
Bioscience Laboratory, Mitsui Petrochemical Industries, Ltd, Yamaguchi, Japan
Nat Biotechnol 14:1129-32. 1996..These results suggest that these two regions of methyl jasmonate are important for promoting the production of paclitaxel and related taxanes in Taxus cell cultures...
- Methyl jasmonate induces traumatic resin ducts, terpenoid resin biosynthesis, and terpenoid accumulation in developing xylem of Norway spruce stemsDiane Martin
Max Planck Institute for Chemical Ecology, Carl Zeiss Promenade 10, 07745 Jena, Germany
Plant Physiol 129:1003-18. 2002....
- Protein kinase activity is central to rat germ cell apoptosis induced by methoxyacetic acidT Jindo
Reproductive Toxicology Group, National Toxicology Program, NIEHS, Research Triangle Park, North Carolina, USA
Toxicol Pathol 29:607-16. 2001..Westem blotting and immunocytochemistry confirmed this finding. The data we present implicate kinase activities in the pathogenesis of this lesion and suggest the involvement of Sertoli cells...
- Oral (drinking water) two-generation reproductive toxicity study of dibromoacetic acid (DBA) in ratsM S Christian
Argus Research Laboratories, Inc, Horsham, Pennsylvania 19044, USA
Int J Toxicol 21:237-76. 2002..Based on the high multiples of human exposure required to produce effects in male rats, DBA should not be identified as a human reproductive or developmental risk...
- Targeted proteomics using selected reaction monitoring reveals the induction of specific terpene synthases in a multi-level study of methyl jasmonate-treated Norway spruce (Picea abies)Katherine G Zulak
Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
Plant J 60:1015-30. 2009....
- Induction of anatomically based defense responses in stems of diverse conifers by methyl jasmonate: a phylogenetic perspectiveJ W Hudgins
School of Biological Sciences, Washington State University, Pullman, WA 99164 4236, USA
Tree Physiol 24:251-64. 2004..Co-evolution of conifer defensive strategies and bark beetle pests is discussed...
- Traumatic resin defense in Norway spruce (Picea abies): methyl jasmonate-induced terpene synthase gene expression, and cDNA cloning and functional characterization of (+)-3-carene synthaseJenny Fäldt
Biotechnology Laboratory, Department of Botany and Department of Forest Sciences, University of British Columbia, 6174 University Boulevard, Vancouver V6T 1Z3, BC Canada
Plant Mol Biol 51:119-33. 2003..3-Carene is a characteristic monoterpene of constitutive and induced oleoresin defense of Norway spruce and other members of the Pinaceae...
- Modulation of MAA-induced apoptosis in male germ cells: role of Sertoli cell P/Q-type calcium channelsFortunata Barone
Department of Histology and Medical Embryology, University of Rome La Sapienza, 00161 Rome, Italy
Reprod Biol Endocrinol 3:13. 2005..The results obtained demonstrate that Sertoli cells modulate germ cell apoptosis induced by methoxyacetic acid also throughout the P/Q-type VOCC's...
- Ontogeny constrains systemic protease inhibitor response in Nicotiana attenuataN M van Dam
Max-Planck-Institute for Chemical Ecology, Carl-Zeiss-Promenade 10, D-07745 Jena, Germany
J Chem Ecol 27:547-68. 2001..Interestingly, by the time plants reach the flowering stage, they had lost the ability to increase PI levels after MeJA treatment. We concluded that plant ontogeny constrains both constitutive and inducible PI production in N. attenuata...
- Methyl jasmonate treatment of mature Norway spruce (Picea abies) trees increases the accumulation of terpenoid resin components and protects against infection by Ceratocystis polonica, a bark beetle-associated fungusGazmend Zeneli
Max Planck Institute for Chemical Ecology, Hans Knöll Str 8, D 07745 Jena, Germany
Tree Physiol 26:977-88. 2006..The observed chemical and anatomical changes in response to MJ treatment were correlated with increased resistance to C. polonica, suggesting that terpenoid oleoresin may function in defense against this pathogen...
- Diethylene glycol monomethyl ether, ethylene glycol monomethyl ether and the metabolite, 2-methoxyacetic acid affect in vitro chondrogenesisEmily Hanson Scofield
University of Georgia, Department of Environmental Health Science, Athens, GA 30602 2102, USA
Reprod Toxicol 22:718-24. 2006..These results suggest that effects of DEGME and EGME are the result of generalized toxicity, but their metabolite MAA induces mitochondrial-mediated apoptosis during in vitro chondrogenesis...
- Cloning and characterization of two different types of geranyl diphosphate synthases from Norway spruce (Picea abies)Axel Schmidt
Max Planck Institute for Chemical Ecology, Department of Biochemistry, Hans Knoll Strasse 8, D 07745 Jena, Germany
Phytochemistry 69:49-57. 2008..Hence these proteins may not be involved in monoterpene formation and could conceivably form products in addition to GPP in planta...
- Immunofluorescence localization of levopimaradiene/abietadiene synthase in methyl jasmonate treated stems of Sitka spruce (Picea sitchensis) shows activation of diterpenoid biosynthesis in cortical and developing traumatic resin ductsKatherine G Zulak
Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
Phytochemistry 71:1695-9. 2010..Overall, the results of this work improve our understanding of spatial and temporal patterns of induced diterpene resin acid biosynthesis in conifers...
- Resistance of cultivated tomato to cell content-feeding herbivores is regulated by the octadecanoid-signaling pathwayChuanyou Li
Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA
Plant Physiol 130:494-503. 2002..Tight linkage of Def-1 to a T-DNA insertion harboring the maize (Zea mays) Dissociation transposable element suggests a strategy for directed transposon tagging of the gene...
- Methyl jasmonate and oxalic acid treatment of Norway spruce: anatomically based defense responses and increased resistance against fungal infectionPaal Krokene
Norwegian Forest and Landscape Institute, P O Box 155, 1431 As, Norway
Tree Physiol 28:29-35. 2008..In conclusion, MJ treatment of Norway spruce appears to have practical potential as a tool for increasing plant resistance to fungal infection, but with a modest reduction in sapwood growth...
- Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolitesJochem Louisse
Division of Toxicology, Wageningen University, Tuinlaan 5, 6703 HE Wageningen, The Netherlands
Toxicol Appl Pharmacol 245:236-43. 2010..Together, the results presented indicate that a decrease of the pH(i) may be the mechanism of embryotoxicity of the alkoxyacetic acid metabolites of the glycol ethers...
- Jasmonic acid does not mediate root growth responses to wounding in Arabidopsis thalianaLilian Schmidt
Institut Phytosphäre ICG 3, Forschungszentrum Julich GmbH, Julich, Germany
Plant Cell Environ 33:104-16. 2010..thaliana. Overall, the results demonstrate that the reaction of root growth to herbivore-induced JA signalling differs among species, which is discussed in the context of different ecological defence strategies among species...
- Induction of volatile terpene biosynthesis and diurnal emission by methyl jasmonate in foliage of Norway spruceDiane M Martin
Biotechnology Laboratory, University of British Columbia, 6174 University Boulevard, Vancouver, British Columbia, Canada V6T 1Z3
Plant Physiol 132:1586-99. 2003..Based on precedents in other species, the induced emission of terpenes from Norway spruce foliage may have ecological and physiological significance...
- Jasmonate-induced nicotine formation in tobacco is mediated by tobacco COI1 and JAZ genesTsubasa Shoji
Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara, 630 0192 Japan
Plant Cell Physiol 49:1003-12. 2008..These results indicate that jasmonate-triggered, COI1-mediated degradation of JAZ repressors activates transcriptional regulation of nicotine biosynthesis genes in tobacco roots...
- Involvement of caspase 3 mediated apoptosis in hematopoietic cytotoxicity of metabolites of ethylene glycol monomethyl etherAkira Takagi
Department of Medical Technology, Nagoya University School of Health Sciences, Daiko minami 1 1 20, Higashi ku, Nagoya 461 8673, Japan
Ind Health 40:371-4. 2002..Caspase-3 enzyme activity, the effector of the apoptotic process, was greatly enhanced with MALD treatment. The inhibitor of caspase-3 repressed cell death induced with MALD as well as MAA...
- Haloacid induced alterations in fertility and the sperm biomarker SP22 in the rat are additive: validation of an ELISAEmilie H Kaydos
North Carolina State University, Department of Environmental and Molecular Toxicology, Raleigh, North Carolina 27606, USA
Toxicol Sci 81:430-42. 2004..The correlation between SP22 levels by ELISA and fertility was r(2) = 0.72 compared to 0.82 for SP22 levels by 2D SDS-PAGE and fertility, validating SP22 quantitation by ELISA...
- Coordinated transcriptional regulation of the divinyl ether biosynthetic genes in tobacco by signal molecules related to defenseAlessandro Fammartino
University of Turin, DiVaPRA Plant Pathology, Via L da Vinci 44, I 10095 Grugliasco TO, Italy
Plant Physiol Biochem 48:225-31. 2010..Our data suggest that, in tobacco, DVE biosynthesis is cross-regulated by jasmonates, and by other hormonal and signal molecules such as ethylene and SA...
- Methyl jasmonate-induced ethylene production is responsible for conifer phloem defense responses and reprogramming of stem cambial zone for traumatic resin duct formationJ W Hudgins
School of Biological Sciences, Washington State University, Pullman, WA 99164 4236, USA
Plant Physiol 135:2134-49. 2004..The results also indicate a central role of ray parenchyma in ethylene-induced defense...
- Behavior of trihalomethanes and haloacetic acids in a drinking water distribution systemManuel J Rodriguez
École supérieure d aménagement du territoire, et développement régional ESAD, Universite Laval, 1624 Pavillon Savard, Que, Canada G1K 7P4
Water Res 38:4367-82. 2004..The results used in the portrait of CDBP behavior are also relevant in terms of exposure assessment for future epidemiological studies on human reproductive outcomes in the region...
- Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibitionMichelle S Jansen
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 101:7199-204. 2004..Furthermore, our study highlights the need to structure future screening programs to identify additional hormone sensitizers...
- Local photolysis using tapered quartz fibresC Eberius
Physiologisches Institut, , Humboldtallee 23, , Germany
Pflugers Arch 443:323-30. 2001..Site and timing of photolysis can be chosen independently from other experimental parameters. As an application example we show the spatially heterogeneous distribution of Ca2+-dependent Cl- channels in olfactory receptor neurons...
- Characterization of four terpene synthase cDNAs from methyl jasmonate-induced Douglas-fir, Pseudotsuga menziesiiDezene P W Huber
Michael Smith Laboratories and Departments of Botany and Forest Sciences, University of British Columbia, 301 2185 East Mall, Vancouver, BC, Canada V6T 1Z4
Phytochemistry 66:1427-39. 2005....
- Plant-plant signaling: application of trans- or cis-methyl jasmonate equivalent to sagebrush releases does not elicit direct defenses in native tobaccoCatherine A Preston
Department of Molecular Ecology, Max Planck Institute for Chemical Ecology Jena, Germany
J Chem Ecol 30:2193-214. 2004..We conclude that volatile MeJA, either trans- or cis-, when applied at levels consistent with those released by sagebrush does not elicit direct defenses in N. attenuata...
- Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activationSerenella Rotondo
Laboratory of Vascular Biology and Pharmacology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro, Italy
Eur J Pharmacol 488:79-83. 2004..These results indicate that, at clinically relevant concentrations, licofelone exerts a potent antiplatelet effect mediated by the inhibition of cyclooxygenase-1 activity...
- Therapeutic effect of transcatheter arterial chemoembolization and percutaneous injection of acetic acids on primary liver cancerHong Bin Chen
Department of Gastroenterology, Sanming Municipal First Hospital, Sanming 365000, China
Hepatobiliary Pancreat Dis Int 3:55-7. 2004..of present research was to study the efficacy of transcatheter arterial chemoembolization (TACE) combined with percutaneous injection of chemical agents and acetic acids in the treatment of patients with primary liver cancer (PLC).
- The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin KJean Pierre Pelletier
Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada H2L 4M1
Bone 34:527-38. 2004....
- Differential effects of triiodothyronine and the thyroid hormone receptor beta-specific agonist GC-1 on thyroid hormone target genes in the b ainJimena Manzano
Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid, Madrid, Spain
Endocrinology 144:5480-7. 2003..However, in the caudate, RC3 and Rhes are expressed in the same cells, and therefore, they may represent specific gene responses linked to specific thyroid hormone receptor isoforms...
- COX-LOX inhibition: current evidence for an emerging new therapyM M Skelly
Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, UK
Int J Clin Pract 57:301-4. 2003..This review examines the hypothesis that licofelone is an effective anti-inflammatory agent that does not cause peptic damage...
- Jasmonic acid influences mycorrhizal colonization in tomato plants by modifying the expression of genes involved in carbohydrate partitioningMiriam Tejeda-Sartorius
Unidad de Biotecnología e Ingeniería Genética de Plantas Cinvestav Campus Guanajuato, Km 9 6 del Libramiento Norte Carretera Irapuato León, Apartado Postal 629, C P 36821, Irapuato, Guanajuato, Mexico
Physiol Plant 133:339-53. 2008..The significant colonization increase observed in mycorrhizal spr2 plants supplied with exogenous methyl jasmonate supports its role as a positive regulator of the symbiosis...
- Licofelone, a dual lipoxygenase-cyclooxygenase inhibitor, downregulates polymorphonuclear leukocyte and platelet functionSerenella Rotondo
G Bizzozero Laboratory of Blood and Vascular Cell Interactions, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro 66030, Italy
Eur J Pharmacol 453:131-9. 2002..The coexistence within the same molecule of a wide spectrum of anti-inflammatory properties is of interest...
- Methoxyacetic acid disregulation of androgen receptor and androgen-binding protein expression in adult rat testisOscar M Tirado
Unitat de Recerca Biomedica, Hospital Materno Infantil Vall d Hebron, Barcelona, Spain
Biol Reprod 68:1437-46. 2003..It is still unclear whether MAA elicits a proapoptotic signal from Sertoli cells or diminishes a prosurvival signal required by germ cells downstream to altering AR and ABP expression in a stage-specific fashion...
- Metabolomic alterations in elicitor treated Silybum marianum suspension cultures monitored by nuclear magnetic resonance spectroscopyAngeles Sánchez-Sampedro
Department of Plant Physiology, Faculty of Pharmacy, University of Salamanca, 37007 Salamanca, Spain
J Biotechnol 130:133-42. 2007..The results obtained in this study will permit in the future to identify candidate components of the signalling pathway involved in the stimulation of the constitutive pathway of silymarin...
- Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPID W Snyder
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
J Pharmacol Exp Ther 288:1117-24. 1999..This agent is currently undergoing clinical evaluation and should help to define the role of sPLA2 in various inflammatory disease states...
- Characterization of salicylic acid-induced genes in Chinese cabbageY S Park
Division of Life Sciences, Chungbuk National University, 360 763 Cheongju, Korea
Plant Cell Rep 21:1027-34. 2003..tomato, a nonhost pathogen that elicits a hypersensitive response in Chinese cabbage. None of these four genes, however, was strongly induced by methyl jasmonate or by ethylene...
- Methyl jasmonate induces defense responses in grapevine and triggers protection against Erysiphe necatorAssia Belhadj
Laboratoire de Mycologie et Biotechnologie Végétale, EA 3675, Universite Victor Segalen Bordeaux 2, UFR Sciences Pharmaceutiques, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
J Agric Food Chem 54:9119-25. 2006..On the basis of these original results, MeJA can therefore act as an efficient elicitor in an alternative strategy of grapevine protection...
- Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibitionYosabeth Paredes
Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
Arthritis Rheum 46:1804-12. 2002....
- Effect of methyl jasmonate in combination with carbohydrates on gene expression of PR proteins, stilbene and anthocyanin accumulation in grapevine cell culturesAssia Belhadj
Groupe d Etude des Substances Végétales à Activité Biologique, EA 3675, ISVV, Universite Victor Segalen Bordeaux 2, UFR Sciences Pharmaceutiques, Bordeaux Cedex, France
Plant Physiol Biochem 46:493-9. 2008..Methyl jasmonate treatment might be an efficient natural strategy to protect grapevine berries in vineyard...
- [The effect of gabapentin and gabapentin-lactam on retinal ganglion cell survival. Situation after acute retinal ischemia in animal models]T Jehle
Neurologische Universitatsklinik Freiburg, Klinische Neuropharmakologie
Ophthalmologe 98:237-41. 2001..What are the effects of the antiepileptic drug gabapentin, for which antiglutamatergic effects have been described, and the new substance gabapentin-lactam (GBP-L) on retinal ganglion cell survival after retinal ischemia?..
- NOVEL PALLADIUM CATALYZED SYNTHESES OF INDOLE ALKALOIDSBJORN SODERBERG; Fiscal Year: 2001..routes to compounds having an indole nucleus such as 2-fluoro-, 3-fluoro-, and 2,3-difluoroindoles, indole-2-acetic acids, indole-3- acetic acids, indole-3-acetonitriles, tryptamines, beta-carbolines, 1,2,3,4-tetrahydro-beta-..
- Duet cervical barrier device for maximizing protective efficacy of microbicidesRichard Cone; Fiscal Year: 2009..Lactobacilli acidify the vagina to pH~4 by secreting lactic and acetic acids. At this pH these acids can rapidly inactivate pathogens by permeating cell and bacterial membranes, but these ..
- IN VIVO INHIBITORS OF OCULAR PROSTAGLANDIN SYNTHESISSTEVEN PODOS; Fiscal Year: 1980..Many families of compounds inhibit prostaglandin synthesis such as the indole acetic acids, arylacetic acids, anthranilic acids, and pyrazolones...
- H-BONDS AND PROTON TRANSFER IN MODEL PIGMENT CHROMOPHOREPAUL BLATZ; Fiscal Year: 1990..to be studied are: i) donor reagents such as phenol, substituted phenols, acetic acid and chloro substituted acetic acids, ii) selected solvents such as hydrocarbons and chlorohydrocarbons, and iii) changing temperature...
- CONTROLLED RELEASE OF MACROMOLECULESRobert Langer; Fiscal Year: 2007..polymers such as modified poly(ethylene imines), poly(beta-amino esters), and polylysine graft imidizole acetic acids. Despite progress by us and others, existing non-viral delivery systems are far less efficient than viral ..
- New Ligands for Radioimmunotherapy and MRI of CancerHyun Soon Chong; Fiscal Year: 2006..The results of the proposed research will contribute to the development of better drugs for both MRI and RIT, which will greatly enhance clinical exploration of both modalities, and directly benefit cancer patients. ..
- Phase III Trial of Minocycline in ALS-II Data CenterRobert Miller; Fiscal Year: 2007..The details of data management are described, including the methods for quality control, security and information technology. Finally, the analytic plan is described in full. ..
- NADPH P450 REDUCTASE--THYROID HORMONE REGULATIONDavid Waxman; Fiscal Year: 2002....
- Nanoparticle Brain Delivery of Iron Chelators for ADGang Liu; Fiscal Year: 2004..Overall, this: exploratory: study may open the door for the use of iron chelator nanoparticle systems to target diseased organs for iron chelation therapy. ..
- MECHANISMS OF SKELETAL RECONSTITUTION AFTER LACTATIONScott Miller; Fiscal Year: 2004..abstract_text> ..
- LIGAND PHARMACOLOGY OF ESTROGEN RECEPTORSThomas Scanlan; Fiscal Year: 2008..unreadable] [unreadable]..
- AMPHIPATHIC ORAL CHELATORS AND RADIONUCLIDE CONTAMINATIONScott Miller; Fiscal Year: 2008..Because the pharmacology and toxicology of PACA chelators, such as DTPA and EDTA, are quite well understood, the development pathway of the related TT- based chelators may proceed rapidly. ..
- Free Iron, Estrogen and Postmenopausal OsteoporosisGang Liu; Fiscal Year: 2002..Moreover, this new approach will permit the reevaluation of the role of estrogen and will expedite the development of novel pharmaceutical agents for the prevention or treatment of osteoporosis. ..
- Intranasal Methamphetamine: A Pharmacotherapy ModelCarl Hart; Fiscal Year: 2009....
- Drug Effects on Behavior: Workplace ImplicationsCarl Hart; Fiscal Year: 2008..Together, the data from the proposed studies will have substantial public health impact and will serve both educational and public policy functions. ..
- Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancerShaker Mousa; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Mechanisms of H pylori-Induced HypochlorhydriaAdam Smolka; Fiscal Year: 2008..pylori strain identity, and anatomic site of infection. These studies will establish the mechanistic basis of H. pylori-induced gastric hypochlorhydria, and add to the understanding of H. pylori pathophysiology. ..
- THYROID HORMONE CONTROL OF A GENE EXPRESSION NETWORKJ Furlow; Fiscal Year: 2008..abstract_text> ..
- Non-Peptide Somatostatin Agonist AnalgesicsSusan Carlton; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- PHYSIOLOGY OF ESTROGEN'S MOOD EFFECT IN MENOPAUSAL WOMENHadine Joffe; Fiscal Year: 2007..Such training will lay the foundation for a career of clinical investigation into the physiology of perimenopausal depression and the impact of hot flushes on sleep, mood, and quality-of-life. ..
- SMART: Improving Detection & Outcome of Psychiatric Comorbidity in Drug TreatmentCarlos Blanco; Fiscal Year: 2010..abstract_text> ..
- SPLENIC TOXICITY OF ANILINEM Firoze Khan; Fiscal Year: 2010..These studies will elucidate the mechanisms of aniline-induced splenic toxicity, and will be important in devising strategies to prevent toxicity, and in risk assessment of aniline and other structurally-related aromatic amines. ..
- Bipolar Statistical Summit:Methodologies to Advance Long Term Intervention TrialsCharles Bowden; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Emory Conte Center for the Neuroscience of Mental DisordersBecky Kinkead; Fiscal Year: 2008..abstract_text> ..
- Mixture Modeling: Pesticide Drug InteractionsCharles Timchalk; Fiscal Year: 2009..It is fully anticipated that this approach will facilitate the understanding of a variety of complex chemical interactions as it relates to the occupational health implications of working with insecticides. ..
- Development of Selective Nanoporous Sorbents for Radionuclide DecorporationCharles Timchalk; Fiscal Year: 2008..abstract_text> ..
- MUTATION ANALYSIS OF THYROID HORMONE FUNCTIONJohn Baxter; Fiscal Year: 2009..These studies should provide substantial insight into TR function that is relevant for understanding TR action, mechanism of action of other NRs, regulation of gene expression and pharmaceutical design. ..
- BRANCHED CHAIN AMINO ACID METABOLISMSUSAN HUTSON; Fiscal Year: 2008..Results from this study will provide new insights into the role(s) played by BCAAs and high protein diets in weight loss and energy expenditure. ..
- PROTEIN KINASE C IN THE LENSDOLORES JEAN TAKEMOTO; Fiscal Year: 2010..Activation of these enzymes, using targeted drugs, could prevent or delay ocular damage during oxidative insult or ischemia. ..
- Reconsolidation and extinction processes in the treatment of drug addictionYossef Itzhak; Fiscal Year: 2010..abstract_text> ..
- Substance Use Comorbidity Care: Evidence-Based Stepped Strategies for DepressionCarlos Blanco; Fiscal Year: 2010..abstract_text> ..
- Mixture Toxicity - Evaluation of an Improved MethodologyDOUGLAS DAWSON; Fiscal Year: 2008..Environmental releases of these chemicals are possible, which could also affect public health. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Adolescent Exposure to Psychostimulants: Role of nNOSYossef Itzhak; Fiscal Year: 2008..Results of these studies would provide new information on mechanisms that underlie the development of hypersensitivity to these drugs from adolescence through adulthood. ..
- Long Term Toxicity of Di- and Tri-ChloroacetateEzdihar Hassoun; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Selective Modulation of Thyroid Receptor ActionJohn Baxter; Fiscal Year: 2007..This study will expand our understanding of selective TR modulation in specific and NR action in general. ..
- TOSCA-2 An Angiographic Substudy of the Occluded Arter*Vladimir Dzavik; Fiscal Year: 2004..The Data Coordinating Center (DCC) is the Maryland Medical Research Institute, the DCC of OAT. The An2iogiraphic Core Laboratory is at the University of British Columbia. ..
- Integration by Airway Parasympathic Ganglia NeuronsAllen Myers; Fiscal Year: 2004..We feel that an understanding of the mechanism of this integration is a prerequisite to obtaining knowledge on the mechanisms by which airway neurophysiology is regulated in health and disregulated in disease. ..
- ADRIAMYCIN-INDUCED MITOCHONDRIAL CARDIOMYOPATHYKendall Wallace; Fiscal Year: 2004....
- PERIPHERAL SOMATOSTATIN CONTROLS INFLAMMATORY PAINSusan Carlton; Fiscal Year: 2004..Peripheral SST receptors offer novel targets for nociceptor modulation and are likely targets for further development of non-opioid therapies to aid in reducing the pain and long-term deleterious changes that can accompany inflammation. ..
- Student Travel to the Environmental Mutagen SocietyMichael Plewa; Fiscal Year: 2003..Awards will be made without regard to gender, race or ethnicity or disability. ..
- CANCER CHEMOPREVENTION--ROLE OF INFECTION/IMMUNITYCharles Loprinzi; Fiscal Year: 2003..abstract_text> ..
- Multidiscipli. GCRC-Mentorship Program in Womens HealthLorraine Fitzpatrick; Fiscal Year: 2003..abstract_text> ..
- Student Travel to the Environmental Mutagen SocietyMichael Plewa; Fiscal Year: 2002..Awards will be made without regard to gender, race or ethnicity. ..
- BEHAVIORAL MECHANISM IN HIGH RISK POPULATIONSDON CHEREK; Fiscal Year: 2001..Demonstrating such fundamental differences may lead to different approaches in attempts to modify antisocial behavior among high risk populations with such behavioral tendencies. ..
- Screening for comorbidity in substance abuse clinicsCarlos Blanco; Fiscal Year: 2004..abstract_text> ..
- Surrogate Biomarkers of Micrometastatic Gastric CancerAdam Smolka; Fiscal Year: 2004..The successful development and validation of a lymph node RT-PCR-based assay for micrometastatic stomach cancer is likely to have a significant clinical impact. ..
- Student Travel to the Environmental Mutagen SocietyMichael Plewa; Fiscal Year: 2004..Awards will be made without regard to gender, race, ethnicity or disability. ..
- Expression of Therapeutic Proteins in the Whole LensDolores Takemoto; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- NRTI-induced Mitochondrial CardiomyopathyKendall Wallace; Fiscal Year: 2006..abstract_text> ..
- INNOVATIVE BIOMONITORING FOR LEAD IN SALIVACharles Timchalk; Fiscal Year: 2006..It is reasonable to speculate that once this model system has been adequately validated it can readily be employed to screen sensitive populations (e.g. children) that are at greatest risk from chronic Pb exposure. ..
- ALTERING BEHAVIORAL RISK FOR DRUG DEPENDENCEDON CHEREK; Fiscal Year: 2001..Pharmacological effects of these therapeutics drugs on such behavior in a high risk population may provide information relating to alternative strategies in dealing with drug dependence. ..
- Peripherial and Central Mechanisms of Tinnitus GeneratCarol Bauer; Fiscal Year: 2006..Safe and efficacious therapy for this prevalent and often debilitating problem can only occur with improved understanding of the disorder. ..
- Xenobiotics, Lipid Peroxidation and AutoimmunityM Firoze Khan; Fiscal Year: 2006..abstract_text> ..
- Pretargeting mouse tumor with anti-PSMA antibody-MORFGuozheng Liu; Fiscal Year: 2005..Based on our experiences in this pretargeting strategy, we are confident that these investigations on the pretargeting imaging of prostate cancer models with MORFs will be successful. ..
- Substituted Amphetamines: NO-Dependent MechanismsYossef Itzhak; Fiscal Year: 2005....
- CHRONIC CENTRAL PAIN IN SPINAL CORD INJURYCLAIRE HULSEBOSCH; Fiscal Year: 2005..There are three cores: an administrative core, an animal core and a morphology core. The results for these studies will guide the development of strategic interventions to improve functional outcome after SCI. ..
- RELEASE CHANNEL ISOFORMS AND LOCAL CALCIUM SIGNALINGNatalia Shirokova; Fiscal Year: 2003..Proposed studies will greatly advanced our knowledge of their functioning, which in turn could improve our understanding of their role in decease. ..
- Proteomics of M-L antigens modulating cation transportPETER LAUF; Fiscal Year: 2004....
- Third Symposium Cell Volume & Signalling RegulationPETER LAUF; Fiscal Year: 2003..This meeting's success on U.S. soil will foster continuation of gathering of high-caliber scientists at subsequent international meetings ..
- Mechanisms Causing Cryptorchidism and Fetal Transformation of Testicular CellsD N Rao Veeramachaneni; Fiscal Year: 2007..Results will clarify the interaction of genetics and EDAs as cause of cryptorchidism. [unreadable] [unreadable] [unreadable]..
- Fetal Basis of Sexual Dysfunction: Brain DifferentiationD N Rao Veeramachaneni; Fiscal Year: 2007..By using a relevant and yet practical animal model the proposed studies will advance the knowledge base in pollutant-induced sexual/erectile dysfunction, an area pivotal to reproductive health/success in humans. [unreadable] [unreadable]..