carboxylic acids

Summary

Summary: Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.

Top Publications

  1. ncbi The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
    Andrew J Brown
    Department of 7TMR Systems Research, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom
    J Biol Chem 278:11312-9. 2003
  2. ncbi Metabolic engineering of Saccharomyces cerevisiae for production of carboxylic acids: current status and challenges
    Derek A Abbott
    Department of Biotechnology, Delft University of Technology, Delft, The Netherlands
    FEMS Yeast Res 9:1123-36. 2009
  3. ncbi Mandipropamid targets the cellulose synthase-like PiCesA3 to inhibit cell wall biosynthesis in the oomycete plant pathogen, Phytophthora infestans
    Mathias Blum
    Syngenta Crop Protection AG, CH 4332 Stein, Switzerland
    Mol Plant Pathol 11:227-43. 2010
  4. ncbi A single point mutation in the novel PvCesA3 gene confers resistance to the carboxylic acid amide fungicide mandipropamid in Plasmopara viticola
    Mathias Blum
    Institute of Botany, University of Basel, Basel, Switzerland
    Fungal Genet Biol 47:499-510. 2010
  5. pmc Genome-based metabolic engineering of Mannheimia succiniciproducens for succinic acid production
    Sang Jun Lee
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejeon 305 701, Republic of Korea
    Appl Environ Microbiol 72:1939-48. 2006
  6. pmc 2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases
    Pinhong Chen
    Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, United States
    Bioorg Med Chem Lett 22:6229-32. 2012
  7. ncbi Simultaneous determination of soluble sugars and organic acids as their trimethylsilyl derivatives in apricot fruits by gas-liquid chromatography
    F Bartolozzi
    Departimento di Colture Arboree, , Italy
    J Chromatogr A 758:99-107. 1997
  8. ncbi Electron transfer reduction of carboxylic acids using SmI2-H2O-Et3N
    Michal Szostak
    School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom
    Org Lett 14:840-3. 2012
  9. pmc Oxidation of N-Nitrosoalkylamines by human cytochrome P450 2A6: sequential oxidation to aldehydes and carboxylic acids and analysis of reaction steps
    Goutam Chowdhury
    Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 285:8031-44. 2010
  10. ncbi Sugar fragmentation in the maillard reaction cascade: formation of short-chain carboxylic acids by a new oxidative alpha-dicarbonyl cleavage pathway
    Tomas Davidek
    Nestle Research Center, P O Box 44, 1000 Lausanne 26, Switzerland, and Nestlé Product Technology Center Orbe, 1350 Orbe, Switzerland
    J Agric Food Chem 54:6677-84. 2006

Research Grants

Detail Information

Publications301 found, 100 shown here

  1. ncbi The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
    Andrew J Brown
    Department of 7TMR Systems Research, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom
    J Biol Chem 278:11312-9. 2003
    ..The identity of the cognate physiological ligands for these receptors is not clear, although propionate is known to occur in vivo at high concentrations under certain pathophysiological conditions...
  2. ncbi Metabolic engineering of Saccharomyces cerevisiae for production of carboxylic acids: current status and challenges
    Derek A Abbott
    Department of Biotechnology, Delft University of Technology, Delft, The Netherlands
    FEMS Yeast Res 9:1123-36. 2009
    ..In addition to recent progress in engineering S. cerevisiae for organic acid production, the key limitations and challenges are discussed in the context of sustainable industrial production of organic acids from renewable feedstocks...
  3. ncbi Mandipropamid targets the cellulose synthase-like PiCesA3 to inhibit cell wall biosynthesis in the oomycete plant pathogen, Phytophthora infestans
    Mathias Blum
    Syngenta Crop Protection AG, CH 4332 Stein, Switzerland
    Mol Plant Pathol 11:227-43. 2010
    ..The transformation and expression of a mutated PiCesA3 allele was carried out in a sensitive wild-type isolate to demonstrate that the mutations in PiCesA3 were responsible for the MPD insensitivity phenotype...
  4. ncbi A single point mutation in the novel PvCesA3 gene confers resistance to the carboxylic acid amide fungicide mandipropamid in Plasmopara viticola
    Mathias Blum
    Institute of Botany, University of Basel, Basel, Switzerland
    Fungal Genet Biol 47:499-510. 2010
    ..Our data demonstrate that the identified genes are putative cellulose synthases and that one recessive mutation in PvCesA3 causes inheritable resistance to the CAA fungicide mandipropamid...
  5. pmc Genome-based metabolic engineering of Mannheimia succiniciproducens for succinic acid production
    Sang Jun Lee
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejeon 305 701, Republic of Korea
    Appl Environ Microbiol 72:1939-48. 2006
    ..4 g/liter of succinic acid, with a succinic acid yield of 1.16 mol succinic acid per mol glucose and a succinic acid productivity of 1.8 g/liter/h, which should be useful for industrial production of succinic acid...
  6. pmc 2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases
    Pinhong Chen
    Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, United States
    Bioorg Med Chem Lett 22:6229-32. 2012
    ..We report several 2-substituted 4,5-dihydrothiazole-4-carboxylic acids to be novel MBL inhibitors...
  7. ncbi Simultaneous determination of soluble sugars and organic acids as their trimethylsilyl derivatives in apricot fruits by gas-liquid chromatography
    F Bartolozzi
    Departimento di Colture Arboree, , Italy
    J Chromatogr A 758:99-107. 1997
    ....
  8. ncbi Electron transfer reduction of carboxylic acids using SmI2-H2O-Et3N
    Michal Szostak
    School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom
    Org Lett 14:840-3. 2012
    The first general method for efficient electron transfer reduction of carboxylic acids has been developed...
  9. pmc Oxidation of N-Nitrosoalkylamines by human cytochrome P450 2A6: sequential oxidation to aldehydes and carboxylic acids and analysis of reaction steps
    Goutam Chowdhury
    Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 285:8031-44. 2010
    ..parameters measured for oxidation of DMN and DEN to the aldehydes and for oxidation of the aldehydes to the carboxylic acids. Spectral analysis did not indicate strong affinity of the aldehydes for P450 2A6, but pulse-chase ..
  10. ncbi Sugar fragmentation in the maillard reaction cascade: formation of short-chain carboxylic acids by a new oxidative alpha-dicarbonyl cleavage pathway
    Tomas Davidek
    Nestle Research Center, P O Box 44, 1000 Lausanne 26, Switzerland, and Nestlé Product Technology Center Orbe, 1350 Orbe, Switzerland
    J Agric Food Chem 54:6677-84. 2006
    The formation of short-chain carboxylic acids was studied in Maillard model systems (90 degrees C, pH 6-10) with emphasis on the role of oxygen and water. The total amount of acetic acid formed did not depend on the reaction atmosphere...
  11. ncbi Reduction of carboxylic acids by Nocardia aldehyde oxidoreductase requires a phosphopantetheinylated enzyme
    Padmesh Venkitasubramanian
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, Iowa 52242 5000, USA
    J Biol Chem 282:478-85. 2007
    ..carboxylic acid reductase (Car)) catalyzes the magnesium-, ATP-, and NADPH-dependent reduction of carboxylic acids to their corresponding aldehydes...
  12. ncbi Copper complexes of nicotinic-aromatic carboxylic acids as superoxide dismutase mimetics
    Thummaruk Suksrichavalit
    Department of Clinical Microbiology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
    Molecules 13:3040-56. 2008
    ..This study reports the synthesis of novel mixed ligand complexes of copper with nicotinic and other select carboxylic acids (phthalic, salicylic and anthranilic acids)...
  13. ncbi Malate exudation by six aerobic rice genotypes varying in zinc uptake efficiency
    Xiaopeng Gao
    Key Laboratory of Plant Soil Interactions, MOE, Beijing, PR China
    J Environ Qual 38:2315-21. 2009
    ..The results also emphasize that effects of root exudates on soil properties need to be assessed to evaluate the role of root exudation in nutrient mobilization...
  14. ncbi Engineering of an L-arabinose metabolic pathway in Corynebacterium glutamicum
    Hideo Kawaguchi
    Research Institute of Innovative Technology for the Earth, 9 2 Kizugawadai, Kizugawa, Kyoto, 619 0292, Japan
    Appl Microbiol Biotechnol 77:1053-62. 2008
    ..Strain CRA1 is, therefore, able to utilize L-arabinose as a substrate for organic acid production even in the presence of D-glucose...
  15. ncbi Chemical rescue of the post-translationally carboxylated lysine mutant of allantoinase and dihydroorotase by metal ions and short-chain carboxylic acids
    Ya Yeh Ho
    Department of Biomedical Sciences, Chung Shan Medical University, No 110, Sec 1, Chien Kuo N Rd, Taichung, Taiwan
    Amino Acids 44:1181-91. 2013
    ..of the K146A mutant of the ALLase and the K103A mutant of DHOase can be chemically rescued by short-chain carboxylic acids, such as acetic, propionic, and butyric acids, but not by ethanol, propan-1-ol, and imidazole, in the ..
  16. ncbi Breaking through the acid barrier: an orchestrated response to proton stress by enteric bacteria
    J P Audia
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688, USA
    Int J Med Microbiol 291:97-106. 2001
    ..In addition, we will review three dedicated acid resistance systems of E. coli, not present in Salmonella, that allow this organism to survive extreme (pH 2) acid challenge...
  17. ncbi 5-Phenyl substituted 1-methyl-2-pyridones and 4'-substituted biphenyl-4-carboxylic acids. synthesis and evaluation as inhibitors of steroid-5alpha-reductase type 1 and 2
    Franck Picard
    8 5 Pharmaceutical and Medicinal Chemistry, Saarland University, PO Box 15 11 50, D 66041, Saarbrucken, Germany
    Bioorg Med Chem 10:437-48. 2002
    The synthesis of a series of 5-phenyl substituted 1-methyl-2-pyridones (I) and 4'-substituted biphenyl-4-carboxylic acids (II) as novel A-C ring steroidomimetic inhibitors of 5alpha-reductase (5alphaR) is described...
  18. ncbi Presence and partitioning behavior of polyfluorinated iodine alkanes in environmental matrices around a fluorochemical manufacturing plant: another possible source for perfluorinated carboxylic acids?
    Ting Ruan
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085
    Environ Sci Technol 44:5755-61. 2010
    ....
  19. ncbi Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria
    B J Kroesen
    Departments of Pathology and Laboratory Medicine, University Hospital Groningen, 9713 G2 Groningen, The Netherlands
    J Biol Chem 276:13606-14. 2001
    ....
  20. ncbi Metabolic activation of carboxylic acids
    Christian Skonberg
    University of Copenhagen, Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, Universitetsparken 2, 2100 Copenhagen, Denmark
    Expert Opin Drug Metab Toxicol 4:425-38. 2008
    b>Carboxylic acids constitute a large and heterogeneous class of both endogenous and xenobiotic compounds...
  21. ncbi The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies
    Sandra Paiva
    Molecular and Environmental Biology Centre CBMA, Department of Biology, Campus de Gualtar, University of Minho, 4710 057 Braga, Portugal
    Biochem J 454:551-8. 2013
    ..Both lactic acid uptake mechanisms are diminished in sok2 colonies where JEN1 expression is decreased. The Sok2p transcription factor may therefore be involved in the regulation of non-saturable lactic acid uptake in yeast colonies. ..
  22. ncbi Lack of evidence for HLA-linked patterns of odorous carboxylic acids released from glutamine conjugates secreted in the human axilla
    Andreas Natsch
    Biosciences, Givaudan Schweiz AG, Ueberlandstrasse, 138, Duebendorf, 8600, Switzerland
    J Chem Ecol 36:837-46. 2010
    ..Volatile carboxylic acids are the most diverse class of known axillary odorants, and the pattern of these acids is genetically ..
  23. ncbi A model for odour thresholds
    Michael H Abraham
    Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK
    Chem Senses 27:95-104. 2002
    ..to a specific size effect, that might involve odour-binding proteins, and a specific effect for aldehydes and carboxylic acids. Our analysis raises the question of whether selective transport is physically separable from the specific ..
  24. pmc Body odour of monozygotic human twins: a common pattern of odorant carboxylic acids released by a bacterial aminoacylase from axilla secretions contributing to an inherited body odour type
    Fabian Kuhn
    Analytical Chemistry, Givaudan Schweiz AG, Ueberlandstrasse 138, 8600 Duebendorf, Switzerland
    J R Soc Interface 6:377-92. 2009
    ..Volatile carboxylic acids are a key class of known human body odorants...
  25. ncbi Pipping success and liver mRNA expression in chicken embryos exposed in ovo to C8 and C11 perfluorinated carboxylic acids and C10 perfluorinated sulfonate
    Jason M O'Brien
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, 20 Marie Curie Street, Ottawa, Ontario K1N 6N5, Canada
    Toxicol Lett 190:134-9. 2009
    ..Based on the present results for white leghorn chickens, current environmental concentrations of PFOA, PFUdA and PFDS are unlikely to affect the hatching success of wild birds...
  26. ncbi Lipase-catalyzed condensation of p-methoxyphenethyl alcohol and carboxylic acids with different steric and electrical properties in acetonitrile
    Takashi Kobayashi
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Biotechnol Lett 25:3-7. 2003
    The substrate selectivity of Candida antarctica lipase for various carboxylic acids was systematically investigated for their condensation with p-methoxyphenethyl alcohol in acetonitrile...
  27. ncbi Improved liquid chromatography/mass spectrometric analysis of low molecular weight carboxylic acids by ion exclusion separation with electrospray ionization
    Keiji Gamoh
    Faculty of Education, Kochi University, 5 1 Akebono cho 2, Kochi 780 8520, Japan
    Rapid Commun Mass Spectrom 17:685-9. 2003
    ..Formic or acetic acid was used as a mobile phase to separate the carboxylic acids within 15 min...
  28. ncbi Chlorzoxazone esters of some non-steroidal anti-inflammatory (NSAI) carboxylic acids as mutual prodrugs: design, synthesis, pharmacological investigations and docking studies
    Ahmed Z Abdel-Azeem
    Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
    Bioorg Med Chem 17:3665-70. 2009
    ..In addition, docking of the mutual ester prodrugs (6-8) into COX-2 active site was conducted in order to predict the affinity and orientation of these prodrugs at the enzyme active site...
  29. ncbi Pd(O2CCF3)2/benzoquinone: a versatile catalyst system for the decarboxylative olefination of arene carboxylic acids
    Peng Hu
    State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China
    Org Lett 11:2341-4. 2009
    ....
  30. ncbi Response to zinc deficiency of two rice lines with contrasting tolerance is determined by root growth maintenance and organic acid exudation rates, and not by zinc-transporter activity
    Basuki Widodo
    Japan International Research Center for Agricultural Sciences JIRCAS, 1 1 Ohwashi, 305 8686 Tsukuba, Japan
    New Phytol 186:400-14. 2010
    ..Zinc-deficiency tolerance in RIL46 is most likely the result of maintenance of root growth, increased efflux of Zn ligands, and increased uptake of Zn-ligand complexes at low [Zn](ext); these traits are potential breeding targets...
  31. ncbi Short-chain carboxylic acids from gray catbird (Dumetella carolinensis) uropygial secretions vary with testosterone levels and photoperiod
    Rebecca J Whelan
    Department of Chemistry and Biochemistry, Oberlin College, Oberlin, OH 44074, USA
    Comp Biochem Physiol B Biochem Mol Biol 156:183-8. 2010
    ..We consistently detected the following carboxylic acids: acetic, propanoic, 2-methylpropanoic, butanoic, and 3-methylbutanoic...
  32. ncbi Palladium-catalyzed decarboxylative coupling of alkynyl carboxylic acids with benzyl halides or aryl halides
    Wen wu Zhang
    College of Chemistry and Materials Science, Wenzhou University, Wenzhou 325035, China
    J Org Chem 75:5259-64. 2010
    ..1,2-diarylalkynes has been developed via palladium-catalyzed decarboxylative coupling reactions of alkynyl carboxylic acids with benzyl chlorides or aryl halides...
  33. ncbi Novel polyene carboxylic acids from Streptomyces
    Silke C Wenzel
    Pharmazeutische Biotechnologie, Universitat des Saarlandes, Gebäude 8 1, D 66123 Saarbrucken, Germany
    J Nat Prod 67:1631-3. 2004
    ..Tü 3851 revealed the presence of additional polyene carboxylic acids. The methyl esters of the new all-trans serpentene (2) and four new dicarboxylic acids (3-6) were isolated ..
  34. ncbi A broad diversity of volatile carboxylic acids, released by a bacterial aminoacylase from axilla secretions, as candidate molecules for the determination of human-body odor type
    Andreas Natsch
    Givaudan Schweiz AG, Ueberlandstrasse 138, CH 8600 Duebendorf, Switzerland
    Chem Biodivers 3:1-20. 2006
    ..Over 28 different carboxylic acids were released by this enzyme from odorless axilla secretions (Table 1)...
  35. ncbi Metal-free synthesis of aryl esters from carboxylic acids and diaryliodonium salts
    Tue B Petersen
    Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE 106 91 Stockholm, Sweden
    Org Lett 13:3462-5. 2011
    An efficient arylation of carboxylic acids with diaryliodonium salts has been developed, giving aryl esters in high yields within short reaction times for both aromatic and aliphatic substrates...
  36. ncbi On the interaction of aliphatic amines and ammonium ions with carboxylic acids in solution and in receptor pockets
    Peter I Nagy
    Center for Drug Design and Development, The University of Toledo, Toledo, Ohio 43606, USA
    J Phys Chem B 116:5425-36. 2012
    ....
  37. pmc Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors
    Satish Kumar
    Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana 136119, India
    Bioorg Med Chem 20:4237-44. 2012
    ..Thirty novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids (B01-B30) were synthesized and evaluated for their TMEM16A inhibitory activity by using short circuit current ..
  38. ncbi Method for rapid detection of the PvCesA3 gene allele conferring resistance to mandipropamid, a carboxylic acid amide fungicide, in Plasmopara viticola populations
    Yoshinao Aoki
    The Institute of Enology and Viticulture, University of Yamanashi, Kofu, Yamanashi, Japan
    Pest Manag Sci 67:1557-61. 2011
    ..The occurrence of carboxylic acid amide (CAA)-fungicide-resistant Plasmopara viticola populations is becoming a serious problem in the control of grapevine downy mildew worldwide...
  39. ncbi Montiporic acids A and B, cytotoxic and antimicrobial polyacetylene carboxylic acids from eggs of the scleractinian coral Montipora digitata
    N Fusetani
    Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan
    J Nat Prod 59:796-7. 1996
    Two new polyacetylene carboxylic acids, montiporic acids A (1) and B (2), have been isolated from the eggs of the scleractinian coral Montipora digitata and their structures elucidated on the basis of spectroscopic data...
  40. ncbi Biocatalytic reduction of short-chain carboxylic acids into their corresponding alcohols with syngas fermentation
    Jose M Perez
    Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA
    Biotechnol Bioeng 110:1066-77. 2013
    Short-chain carboxylic acids generated by various mixed- or pure-culture fermentation processes have been considered valuable precursors for production of bioalcohols...
  41. ncbi Stereospecific synthesis of (R)-2-hydroxy carboxylic acids using recombinant E. coli BL21 overexpressing YiaE from Escherichia coli K12 and glucose dehydrogenase from Bacillus subtilis
    Hyungdon Yun
    School of Chemical Engineering and Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Korea
    Biotechnol Prog 21:366-71. 2005
    ..The purified enzyme catalyzes reduction of various aromatic and aliphatic 2-oxo carboxylic acids to the corresponding (R)-2-hydoxy carboxylic acids using NADPH...
  42. ncbi A propionate CoA-transferase of Ralstonia eutropha H16 with broad substrate specificity catalyzing the CoA thioester formation of various carboxylic acids
    Nicole Lindenkamp
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, Corrensstraße 3, 48149, Munster, Germany
    Appl Microbiol Biotechnol 97:7699-709. 2013
    ..spectrometry (HPLC/MS) analyses revealed that the enzyme exhibits a broad substrate specificity for carboxylic acids. The formation of the corresponding CoA-thioesters of acetate using propionyl-CoA as CoA donor, and of ..
  43. ncbi Biaryl synthesis via Pd-catalyzed decarboxylative coupling of aromatic carboxylates with aryl halides
    Lukas J Goossen
    Institut fur Organische Chemie, TU Kaiserslautern, Erwin Schrodinger Strasse, Building 54, D 67663 Kaiserslautern, Germany
    J Am Chem Soc 129:4824-33. 2007
    ..for the regiospecific construction of unsymmetrical biaryls is presented, in which easily available salts of carboxylic acids are decarboxylated in situ to give arylmetal species that serve as the nucleophilic component in a catalytic ..
  44. pmc Steroidal carboxylic acids from soft coral Paraminabea acronocephala
    Chih Hua Chao
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 80424, Taiwan
    Mar Drugs 11:136-45. 2013
    Three new steroidal carboxylic acids, paraminabic acids A-C (1-3) were isolated from a Formosan soft coral Paraminabea acronocephala...
  45. ncbi Adsorption of gaseous formaldehyde and carboxylic acids by ammonium-ion-exchanged alpha-zirconium phosphate
    A Hayashi
    Department of Functional Molecular Chemistry, Kobe Pharmaceutical University, Kobe, Hyogo 658 8558, Japan
    J Colloid Interface Sci 283:57-63. 2005
    ..The ammonium ion-exchanged alpha-ZrP could adsorb ill-smelling gases, such as formaldehyde and carboxylic acids (formic acid, acetic acid, propionic acid, and butyric acid)...
  46. pmc Transcriptomic analysis of the role of carboxylic acids in metabolite signaling in Arabidopsis leaves
    Iris Finkemeier
    Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom
    Plant Physiol 162:239-53. 2013
    ..Although some carboxylic acids have been implicated in the regulation of gene expression for select transcripts, it is unclear whether all ..
  47. pmc Olfactory sensitivity and odor structure-activity relationships for aliphatic carboxylic acids in CD-1 mice
    Selçuk Can Güven
    Department of Physics, Chemistry and Biology, Linkoping University, Linkoping, Sweden
    PLoS ONE 7:e34301. 2012
    Using a conditioning paradigm, the olfactory sensitivity of CD-1 mice for a homologous series of aliphatic n-carboxylic acids (ethanoic acid to n-octanoic acid) and several of their isomeric forms was investigated...
  48. ncbi Analogues of neuropeptide Y containing beta-aminocyclopropane carboxylic acids are the shortest linear peptides that are selective for the Y1 receptor
    Norman Koglin
    Institut fur Biochemie, Universitat Leipzig, Talstrasse 33, 04103 Leipzig, Germany
    Angew Chem Int Ed Engl 42:202-5. 2003
  49. ncbi Structure-activity relationship between carboxylic acids and T cell cycle blockade
    Kathleen M Gilbert
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences Arkansas Children s Hospital Research Institute, Little Rock, 72202, USA
    Life Sci 78:2159-65. 2006
    This study was designed to examine the potential structure-activity relationship between carboxylic acids, histone acetylation and T cell cycle blockade...
  50. ncbi Cytotoxic C47-polyacetylene carboxylic acids from a marine sponge Pertrosia sp
    Chikane Okamoto
    Laboratory of Aquatic Natural Products Chemistry, Garaduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    J Nat Prod 70:1816-9. 2007
    Two new polyacetylene carboxylic acids, petroformynic acids B (3) and C (4), were isolated from a marine sponge Pertrosia sp. as cytotoxic constituents...
  51. ncbi Sequential ethoxycarbonylation, methoximation and tert-butyldimethylsilylation for simultaneous determination of amino acids and carboxylic acids by dual-column gas chromatography
    Man Jeong Paik
    College of Pharmacy, Sungkyunkwan University, Suwon, Kyunggi Do 440 746, South Korea
    J Chromatogr A 1034:13-23. 2004
    ..on dual-columns with different polarities, which provided simultaneous separation of multiple amino acids, carboxylic acids (CAs) and keto acids, facilitating accurate peak confirmation based on matching with retention index sets ..
  52. ncbi Prediction of pKa values for aliphatic carboxylic acids and alcohols with empirical atomic charge descriptors
    Jinhua Zhang
    Computer Chemie Centrum and Institut für Organische Chemie, Universitat Erlangen Nurnberg, Nagelsbachstrasse 25, D 91052, Erlangen, Germany
    J Chem Inf Model 46:2256-66. 2006
    Two quantitative pKa prediction models for aliphatic carboxylic acids and for alcohols were developed by multiple linear-regression (MLR) analysis with empirical atomic descriptors...
  53. ncbi Development of an HPLC-fluorescence determination method for carboxylic acids related to the tricarboxylic acid cycle as a metabolome tool
    Kazuyuki Kubota
    Laboratory of Bio Analytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biomed Chromatogr 19:788-95. 2005
    We report the simultaneous determination of the carboxylic acids related to the tricarboxylic acid (TCA) cycle, which plays an important role in producing adenosine triphosphate (ATP) and generating energy in mitochondria...
  54. ncbi Induction of the mitochondrial permeability transition in vitro by short-chain carboxylic acids
    C M Palmeira
    Department of Biochemistry and Molecular Biology, University of Minnesota School of Medicine, Duluth 55812, USA
    Biochem Biophys Res Commun 272:431-5. 2000
    ..of the present investigation was to determine if induction of the MPT is a general response to short-chain carboxylic acids or if there are critical physical chemical parameters for this response...
  55. ncbi Lupane-triterpene carboxylic acids from the leaves of Acanthopanax trifoliatus
    Phan Van Kiem
    Institute of Natural Products Chemistry, NCST, Caugiay, Hanoi, Vietnam
    Chem Pharm Bull (Tokyo) 51:1432-5. 2003
    Two new lupane-triterpene carboxylic acids, called acantrifoic acid A (1) and acantrifoside C (2) have been isolated from the leaves of Acanthopanax trifoliatus...
  56. ncbi Simultaneous analysis of amino acids and carboxylic acids by capillary electrophoresis-mass spectrometry using an acidic electrolyte and uncoated fused-silica capillary
    Masataka Wakayama
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Anal Chem 82:9967-76. 2010
    ..spectrometry (CE-MS) method is demonstrated for the simultaneous analysis of amino acids and small carboxylic acids (glycerate, lactate, fumarate, succinate, malate, tartrate, citrate, iso-citrate, cis-aconitate, and ..
  57. pmc The antimutagenicity of 2-substituted selenazolidine-4-(R)-carboxylic acids
    Wael M El-Sayed
    University of Utah, Department of Pharmacology and Toxicology, Salt Lake City, UT 84112, USA
    Mutat Res 627:136-45. 2007
    ..Selenazolidine-4-(R)-carboxylic acids (SCAs) were devised as prodrugs of L-selenocysteine, to provide selenium in a form and at a concentration ..
  58. ncbi Direct amidation of carboxylic acids catalyzed by ortho-iodo arylboronic acids: catalyst optimization, scope, and preliminary mechanistic study supporting a peculiar halogen acceleration effect
    Nicolas Gernigon
    Department of Chemistry, University of Alberta, Gunning Lemieux Chemistry Centre, Edmonton, Alberta, T6G 2G2, Canada
    J Org Chem 77:8386-400. 2012
    ..and synthetic products motivates the development of catalytic, direct amidation methods employing free carboxylic acids and amines that circumvent the need for stoichiometric activation or coupling reagents...
  59. ncbi The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors
    Yibin Xiang
    Department of Medicinal Chemistry, Drug and Biomaterial R and D, Genzyme Corp, 153 Second Avenue, Waltham, MA 02451, USA
    Bioorg Med Chem Lett 21:3050-6. 2011
    Novel benzofuran-2-carboxylic acids, exemplified by 29, 38 and 39, have been discovered as potent Pim-1 inhibitors using fragment based screening followed by X-ray structure guided medicinal chemistry optimization...
  60. ncbi Fermentation of sugarcane bagasse and chicken manure to calcium carboxylates under thermophilic conditions
    Zhihong Fu
    Department of Microbiology and Cell Science, Florida Center for Renewable Chemicals and Fuels, University of Florida, PO Box 110700, Gainesville, FL 32611 0700, USA
    Appl Biochem Biotechnol 162:561-78. 2010
    Sugarcane bagasse and chicken manure were anaerobically fermented to carboxylic acids using a mixed culture of marine microorganisms at 55 degrees C...
  61. ncbi High capacity hydrogen adsorption in Cu(II) tetracarboxylate framework materials: the role of pore size, ligand functionalization, and exposed metal sites
    Xiang Lin
    School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    J Am Chem Soc 131:2159-71. 2009
    ..However, although increasing the overlap of potential energy fields of pore walls increases the heat of H2 adsorption at low pressure, it may be detrimental to the overall adsorption capacity by reducing the pore volume...
  62. ncbi High performance column liquid chromatographic analysis of selected carboxylic acids in Biomphalaria glabrata patently infected with Schistosoma mansoni
    Daniel R Massa
    Department of Chemistry, Lafayette College, Easton, PA 18042, USA
    Parasitol Res 101:925-8. 2007
    ..chromatography (HPLC) was used to determine the effects of a patent Schistosoma mansoni infection on certain carboxylic acids in the digestive gland gonad complex (DGG) and hemolymph of Biomphalaria glabrata...
  63. ncbi Enaminones as building blocks in heterocyclic syntheses: reinvestigating the product structures of enaminones with malononitrile. A novel route to 6-substituted-3-oxo-2,3-dihydropyridazine-4-carboxylic acids
    Abdul aziz Alnajjar
    Applied Science Department, College of Technological Studies, Public Authority for Applied Education and Training, Safat, Kuwait
    Molecules 14:68-77. 2009
    ..A novel route to 2,3-dihydropyridazine-4-carboxylic acids 4a-c via reactions of 2-cyano-5-(dimethylamino)-5-arylpenta-2,4-dienamides 8a-c with nitrous acid or with ..
  64. ncbi Conversion of municipal solid wastes to carboxylic acids by thermophilic fermentation
    Wen Ning Chan
    Department of Chemical Engineering, Texas A and M University, College Station, TX 77843 3122, USA
    Appl Biochem Biotechnol 111:93-112. 2003
    The purpose of this research is to generate carboxylic acids from the biodegradable fraction of municipal solid wastes (MSW) and municipal sewage sludge (MSS) by using a thermophilic (55 degrees C), anaerobic, high-solid fermentation...
  65. ncbi 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b
    Philip J Skinner
    Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA, 92121, USA
    Bioorg Med Chem Lett 19:4207-9. 2009
    A series of 5-N,N-disubstituted-5-aminopyrazole-3-carboxylic acids were prepared and found to act as highly potent and selective agonists of the G-Protein Coupled Receptor (GPCR) GPR109b, a low affinity receptor for niacin and some ..
  66. ncbi Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors
    Motohide Sato
    Central Pharmaceutical Research Institute, JT Inc, 1 1 Murasaki cho, Takatsuki, Osaka, 569 1125, Japan
    J Med Chem 52:4869-82. 2009
    ..Here, we show the synthesis and the detailed structure-activity relationship of the quinolone carboxylic acids as a novel monoketo acid class of integrase inhibitors...
  67. pmc Carboxylic acids as biomarkers of Biomphalaria alexandrina snails infected with Schistosoma mansoni
    Salwa M F Abou Elseoud
    Parasitology Department, Ain Shams University, Cairo, Egypt
    Korean J Parasitol 48:127-32. 2010
    ..Quantification of carboxylic acids, using HPLC strategy, was fast, easy, and accurate in prediction of infected and uninfected snails and ..
  68. pmc Evaluation of toxic effects of several carboxylic acids on bacterial growth by toxicodynamic modelling
    Jose Antonio Vazquez
    Grupo de Reciclado e Valorización de Materiais Residuais REVAL, Instituto de Investigacions Marinas CSIC, r Eduardo Cabello, 6, Vigo 36208, Galicia, Spain
    Microb Cell Fact 10:100. 2011
    ..However, they typically provide only descriptive information without modelling the influence of acid concentrations on bacterial kinetics...
  69. ncbi The kinetics of photocatalytic degradation of aliphatic carboxylic acids in an UV/TiO2 suspension system
    Q Chen
    College of Atmospheric Sciences, Lanzhou University, Lanzhou, China
    Environ Technol 30:1103-9. 2009
    Kinetic studies on the photocatalytic degradation of aliphatic carboxylic acids were carried out in a slurry photoreactor with in-situ monitoring, employing artificial UV light as the source of energy and nano-TiO2 powder as the catalyst...
  70. ncbi Determining the molecular interactions of perfluorinated carboxylic acids with human sera and isolated human serum albumin using nuclear magnetic resonance spectroscopy
    Jessica C D'eon
    Department of Chemistry, University of Toronto, Toronto, Ontario, M5S 3H6 Canada
    Environ Toxicol Chem 29:1678-88. 2010
    ..Perfluorohexanoic acid (PFHxA) and PFOA were used as model perfluorinated carboxylic acids (PFCAs) to characterize the major site of PFCA interaction in human sera...
  71. pmc Structure-activity relationships on the odor detectability of homologous carboxylic acids by humans
    J Enrique Cometto-Muniz
    Chemosensory Perception Laboratory, Department of Surgery Otolaryngology, University of California, San Diego, 9500 Gilman Dr, Mail Code 0957, La Jolla, CA 92093 0957, USA
    Exp Brain Res 207:75-84. 2010
    ..We discuss the mechanistic implications of this model for the process of olfactory detection...
  72. ncbi Rapid synthesis of 1,3,5-substituted 1,2,4-triazoles from carboxylic acids, amidines, and hydrazines
    Georgette M Castanedo
    Discovery Chemistry Group, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    J Org Chem 76:1177-9. 2011
    A general method for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed from reaction of carboxylic acids, primary amidines, and monosubstituted hydrazines...
  73. ncbi Conversion of sugarcane bagasse to carboxylic acids using a mixed culture of mesophilic microorganisms
    Piyarat Thanakoses
    Department of Chemical Engineering, 3122 TAMU, Texas A and M University, College Station, TX 77843 3122, USA
    Appl Biochem Biotechnol 105:523-46. 2003
    Using the MixAlco process, biomass can be converted into carboxylic acids, which can be chemically converted into mixed alcohol fuels...
  74. ncbi The pKa values of PFOA and other highly fluorinated carboxylic acids
    Kai Uwe Goss
    UFZ Helmholtz Centre for Environmental Research, Permoserstr 15, 04318 Leipzig, Germany
    Environ Sci Technol 42:456-8. 2008
    ..Here, the correct value is estimated to be close to -0.5 based on analogy considerations and molecular modeling. Calculated pKa values for other highly fluorinated carboxylic acids are also presented.
  75. ncbi Analysis of carboxylic acids in biological fluids by capillary electrophoresis
    Beatriz Baena
    Sección Química Analítica, Fac CC Experimentales y de la Salud, Universidad San Pablo CEU, Madrid, Spain
    Electrophoresis 26:2622-36. 2005
    ..The use of microchip devices and CE-MS couplings for organic acid analysis is also discussed...
  76. ncbi Synthesis and potassium channel opening activity of substituted 10H-benzo[4,5]furo[3,2-b]indole-and 5,10-dihydro-indeno[1,2-b]indole-1-carboxylic acids
    J A Butera
    Medicinal Chemistry, Chemical Sciences, Wyeth Ayerst Research, CN 8000, Princeton, NJ 08543, USA
    Bioorg Med Chem Lett 11:2093-7. 2001
    Compounds in a structurally novel series of substituted 10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acids and related 5,10-dihydro-indeno[1,2-b]indole-1-carboxylic acids were prepared and shown to possess potent, bladder-selective smooth ..
  77. ncbi Synthesis and antiprotozoan evaluation of new alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids
    Julieta Coro
    Laboratorio de Síntesis Orgánica, Facultad de Quimica, Universidad de La Habana, 10400 Ciudad Habana, Cuba
    Bioorg Med Chem 13:3413-21. 2005
    Two new series of several alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids were synthesized in a two step procedure from the corresponding alkyl bis-dithiocarbamic salt intermediary...
  78. ncbi Accurate pK(a) calculations for carboxylic acids using complete basis set and Gaussian-n models combined with CPCM continuum solvation methods
    M D Liptak
    Contribution from the Department of Chemistry, Hamilton College, 198 College Hill Road, Clinton, New York 13323, USA
    J Am Chem Soc 123:7314-9. 2001
    ..and Gaussian-n methods were combined with CPCM continuum solvation methods to calculate pK(a) values for six carboxylic acids. An experimental value of -264...
  79. ncbi A new synthesis of indole 5-carboxylic acids and 6-hydroxy-indole-5-carboxylic acids in the preparation of an o-hydroxylated metabolite of vilazodone
    Timo Heinrich
    Merck KGaA, Preclinical Pharmaceutical Research, Frankfurter Str 250, 64293 Darmstadt, Germany
    Bioorg Med Chem Lett 14:2681-4. 2004
    ..Functional group interconversion of carboxylic acid via carboxamide into cyanide was performed with methanesulfonic acid chloride...
  80. ncbi Regiocontrolled intramolecular cyclizations of carboxylic acids to carbon-carbon triple bonds promoted by acid or base catalyst
    Masanobu Uchiyama
    Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba ku, Sendai 980 8578, Japan
    Org Lett 8:5517-20. 2006
    ..time, the relationship between regioselectivity and acid/base effects in the cyclization reactions between carboxylic acids and carbon-carbon triple bonds...
  81. ncbi Dual effects of aliphatic carboxylic acids on cresolase and catecholase reactions of mushroom tyrosinase
    N Gheibi
    Department of Physiology and Medical Physics, Qazvin University of Medical Sciences, Qazvin, Iran
    J Enzyme Inhib Med Chem 24:1076-81. 2009
    ..Thus, they could completely block the cresolase reaction, by preventing monophenol binding to the enzyme. From an allosteric point of view, n-alkyl acids may be involved in activation of MT catecholase reactions...
  82. ncbi Neurochemical analysis of amino acids, polyamines and carboxylic acids: GC-MS quantitation of tBDMS derivatives using ammonia positive chemical ionization
    Paul L Wood
    The Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, 1801 Maple Avenue, Suite 4306, Evanston, IL 60201, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 831:313-9. 2006
    ..Previous workers have utilized this derivative for GC-MS analyses of amino acids, carboxylic acids and urea with electron impact (EI) and with positive chemical ionization (PCI; methane as reagent gas)...
  83. ncbi N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors
    Tjeerd Barf
    Department of Medicinal Chemistry, Biovitrum AB, Research, 112 76 Stockholm, Sweden
    Bioorg Med Chem Lett 19:1745-8. 2009
    ..This led to the identification of a potent and selective class of A-FABP inhibitors as illustrated by N-benzyl-hexahydrocyclohepta[b]indole 30...
  84. ncbi Short-chain carboxylic acids produced by gram-negative anaerobic bacteria can accelerate or delay polymorphonuclear leukocyte apoptosis in vitro
    H W Stehle
    Department of Periodontology, College of Dentistry, The Ohio State University Health Sciences Center, Columbus, USA
    J Periodontol 72:1059-63. 2001
    BACKGROUND: Short-chain carboxylic acids (SCCA) are metabolic byproducts of anaerobic subgingival bacteria associated with human periodontal disease...
  85. ncbi Electrophysiological studies of salty taste modification by organic acids in the labellar taste cell of the blowfly
    Yoshihiro Murata
    Department of Life Science, Graduate School of Science and Technology, Kobe University, Kobe 657 8501, Japan
    Chem Senses 27:57-65. 2002
    ..On the other hand, the salty taste could be depressed by both the lower pH range (pH 2.5-2.0) and the dissociated organic anions from organic acid molecules with at least two carboxyl groups...
  86. ncbi Xenobiotic acyl glucuronides and acyl CoA thioesters as protein-reactive metabolites with the potential to cause idiosyncratic drug reactions
    Urs A Boelsterli
    HepaTox Consulting, CH 4148 Pfeffingen, and Institute of Clinical Pharmacy, University of Basel, Basel, CH 4031, Switzerland
    Curr Drug Metab 3:439-50. 2002
    ..More work is needed to provide a causal link between protein-reactive acyl glucuronides and acyl-CoA thioesters and the rare and unpredictable idiosyncratic drug reactions in humans...
  87. ncbi Parallel synthesis of oxazolines and thiazolines by tandem condensation-cyclodehydration of carboxylic acids with amino alcohols and aminothiols
    Peter Wipf
    Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Comb Chem 4:656-60. 2002
    ..Free carboxylic acids were directly condensed with amino alcohols and aminothiols in the presence of 3-nitrophenylboronic acid as a ..
  88. pmc Accumulation of polyhydroxyalkanoic acid containing large amounts of unsaturated monomers in Pseudomonas fluorescens BM07 utilizing saccharides and its inhibition by 2-bromooctanoic acid
    H J Lee
    Division of Applied Life Sciences, Graduate School, Gyeongsang National University, Chinju 660-701, Korea
    Appl Environ Microbiol 67:4963-74. 2001
    ..We suggest that 2-bromooctanoic acid can substitute for the far more expensive (2,000 times) and cell-growth-inhibiting PHA synthesis inhibitor, cerulenin...
  89. ncbi Sesquiterpene carboxylic acids from a wild tomato species affect larval feeding behavior and survival of Helicoverpa zea and Spodoptera exigua (Lepidoptera: Noctuidae)
    J E Frelichowski
    Department of Natural Resources and Environmental Science, University of Illinois, Urbana 61801, USA
    J Econ Entomol 94:1249-59. 2001
    The sesquiterpene carboxylic acids (SCA), (+)-(E)-alpha-santalen-12-oic, (-)-(E)-endo-alpha-bergamoten-12-oic, and (+)-(E)-endo-beta-bergamoten-12-oic acid, are produced in glandular trichomes of Lycopersicon hirsutum f. typicum Humb...
  90. ncbi Determination of carboxylic acids, carbohydrates, glycerol, ethanol, and 5-HMF in beer by high-performance liquid chromatography and UV-refractive index double detection
    M Castellari
    Istituto di Industrie Agrarie, Universita degli Studi di Bologna, Italy
    J Chromatogr Sci 39:235-8. 2001
    A high-performance liquid chromatographic method is proposed for the simultaneous separation of main carboxylic acids, carbohydrates, ethanol, glycerol, and 5-HMF in beer by direct injection...
  91. ncbi A fluorogenic reagent, 4-mercapto-7-methylthio-2,1,3-benzoxadiazole for carboxylic acids, designed by prediction of the fluorescence intensity
    S Uchiyama
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
    Anal Chem 73:2165-70. 2001
    ..we previously proposed 7-acetylamino-4-mercapto-2,1,3-benzoxadiazole (AABD-SH) as a fluorogenic reagent for carboxylic acids. Since then, progress has made it possible to estimate the fluorescence quantum yields of the 4,7-..
  92. ncbi Role of chromatography in the analysis of sugars, carboxylic acids and amino acids in food
    I Molnar-Perl
    Institute of Inorganic and Analytical Chemistry, L Eotvos University, Budapest, Hungary
    J Chromatogr A 891:1-32. 2000
    An overview is presented of chromatographic methods currently in use to determine sugars, carboxylic acids and amino acids in foods: high-performance liquid chromatography, gas chromatography and capillary electrophoresis...
  93. ncbi Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase
    S El Bawab
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, South Carolina 29425, USA
    J Biol Chem 276:16758-66. 2001
    ..The results are discussed in view of a possible regulation of this enzyme by the intracellular pH or by an interaction with cardiolipin and/or phosphatidic acid...
  94. ncbi Combinatorial receptor codes for odors
    B Malnic
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 96:713-23. 1999
    ..Our studies also indicate that slight alterations in an odorant, or a change in its concentration, can change its "code," potentially explaining how such changes can alter perceived odor quality...
  95. ncbi 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b
    Graeme Semple
    J Med Chem 49:1227-30. 2006
    1-Substituted benzotriazole carboxylic acids have been identified as the first reported examples of selective small-molecule agonists of the human orphan G-protein-coupled receptor GPR109b (HM74), a low-affinity receptor for the HDL-..
  96. ncbi Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease
    Brian J Lipworth
    Department of Medicine and Therapeutics, Asthma and Allergy Research Group, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Lancet 365:167-75. 2005
    ..Ultimately, clinicians will want to know whether PDE4 inhibitors are anything more than expensive "designer" theophylline, the archetypal non-selective phosphodiesterase inhibitor...
  97. pmc Enantioselective kinetic resolution of phenylalkyl carboxylic acids using metagenome-derived esterases
    Elena Fernández-Álvaro
    Dept of Biotechnology and Enzyme Catalysis, Institute of Biochemistry, Greifswald University, Felix Hausdorff Str 4, D 17487 Greifswald, Germany
    Microb Biotechnol 3:59-64. 2010
    Enantiomerically pure β-arylalkyl carboxylic acids are important synthetic intermediates for the preparation of a wide range of compounds with biological and pharmacological activities...
  98. ncbi Selective phosphodiesterase-4 inhibitors in chronic obstructive lung disease
    Francisco J Soto
    Division of Pulmonary and Critical Care Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Curr Opin Pulm Med 11:129-34. 2005
    ..Novel anti-inflammatory therapies such as selective phosphodiesterase 4 (PDE4) inhibitors are in clinical development. Their potential role in the management of COPD is described in this review...
  99. pmc The effect of aliphatic carboxylic acids on olfaction-based host-seeking of the malaria mosquito Anopheles gambiae sensu stricto
    Renate C Smallegange
    Laboratory of Entomology, Wageningen University, PO Box 8031, Wageningen 6700 EH, The Netherlands
    J Chem Ecol 35:933-43. 2009
    The role of aliphatic carboxylic acids in host-seeking response of the malaria mosquito Anopheles gambiae sensu stricto was examined both in a dual-choice olfactometer and with indoor traps...
  100. ncbi Exceptional chiral recognition of racemic carboxylic acids by calix[4]arenes bearing optically pure alpha,beta-amino alcohol groups
    Yan Song Zheng
    Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, P R China
    Org Lett 6:1189-92. 2004
    ..structure: see text]..
  101. ncbi Fluorinated alkyl compounds including long chain carboxylic acids in wild bird livers from Japan
    Keerthi S Guruge
    Safety Research Team, National Institute of Animal Health, National Agriculture and Food Research Organization, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    Chemosphere 83:379-84. 2011
    ..in a Japanese sparrowhawk, indicating that the top predatory wild birds can accumulate several long chain carboxylic acids. However, the current FAC concentrations found in livers may suggest that these compounds alone would not ..

Research Grants62

  1. Branched-chain fatty acids and membrane function in Listeria monocytogenes
    BRIAN JAMES WILKINSON; Fiscal Year: 2012
    ..the mechanism of branched-chain fatty acid switching, define the pathway of fatty acid biosynthesis from carboxylic acids, and manipulate the membrane fatty acid composition, and hence fluidity, in an extreme fashion and examine ..
  2. New biomonitoring methodologies to measure DNA adducts in human tissues
    Robert J Turesky; Fiscal Year: 2013
    ..Our chemical model for this project is structurally related nitro-phenanthrene carboxylic acids, a class of human carcinogens and nephrotoxicants that include aristolochic acids (AA)...
  3. Optimization of pyrimidinyl prodrugs (PYPs) for malaria chemotherapy
    PRADIPSINH RATHOD; Fiscal Year: 2009
    ..chemistry, trioxanes and tetraoxane derivatives of PYP1 will be made to selectively release the active carboxylic acids in the parasite (iii) Cell-based screens and toxicity panels will be implemented and used to identify ..
  4. Receptors and Neurons Mediating Acid Taste in Drosophila
    ANUPAMA ARUN DAHANUKAR; Fiscal Year: 2013
    ..cellular mechanisms of carboxylic acid taste in Drosophila, and to identify neurophysiological responses to carboxylic acids in the mosquito, Aedes aegypti...
  5. Molecular basis of insect attraction to human odorants
    KAREN ANNE MENUZ; Fiscal Year: 2012
    ..In particular, I will focus on amines and carboxylic acids, attractive odors found in human emanations...
  6. ION PAIR ALDOL ADDITION REACTIONS
    Andrew Streitwieser; Fiscal Year: 1999
    ..transfer equilibria and reaction kinetics of Aldol and Michael addition reactions to the dilithium salts of carboxylic acids and beta- diketones...
  7. INACTIVATION AND STRUCTURE AND GABA AMINOTRANSFERASE
    Richard Silverman; Fiscal Year: 1999
    ..corresponding acetylenic and fluoromethyl inactivator analogs, substituted phenols as lipophilic isosteres of carboxylic acids, 4-amino-2-difluoromethyl- 2-butenoic acid, 4-amino-2-trifluromethyl-2-butenoic acid, gamma-allenyl GABA, (E)-..
  8. THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENT
    George Sachs; Fiscal Year: 2009
    ..0 and K+ binding to luminal carbonyl groups displaces two of the carboxylic acids bound to lys 791, thereby allowing return ofIys791 and replacement by K+ at this site...
  9. Studies in Amide and Peptide Synthesis
    JEFFREY NICHOLAS JOHNSTON; Fiscal Year: 2013
    ..peptide chemical synthesis, one that complements existing methods based on dehydrative amide synthesis using carboxylic acids and amines...
  10. Refining &Implementing Supramolecular Methods for HTS of EE &Concentration
    Eric V Anslyn; Fiscal Year: 2013
    ..will be to complete a few assays for chiral functional groups that are almost operational (primary amines, carboxylic acids, and ketones), and we will devise an assay for chiral secondary alcohols...
  11. Enhanced Fluoropolymer Membrane Reactors for Production of Pharmaceutical Interme
    Ning Shangguan; Fiscal Year: 2011
    ..Typical reactions include esterifications of carboxylic acids with alcohols, Friedel-Crafts acylations and alkylations, Schiff base, acetal and ketal formation and ..
  12. Enhanced Fluoropolymer Membrane Reactors for Production of Pharmaceutical Interme
    Ning Shangguan; Fiscal Year: 2012
    ..Typical reactions include esterifications of carboxylic acids with alcohols, Friedel-Crafts acylations and alkylations, Schiff base, acetal and ketal formation and ..
  13. Novel agents against West Nile Virus infections
    Krzysztof Pankiewicz; Fiscal Year: 2003
    ..simple, unexplored yet analogues of MPA that are expected to show different physicochemical properties than carboxylic acids (such as MPA) and may show favorable pharmacokinetic...
  14. Practical Strategies for Controlling Selectivity in Organic Reactions
    Amir H Hoveyda; Fiscal Year: 2013
    ..and reversibly bind to a metal catalyst and common organic functional groups (such as alcohols, amines, and carboxylic acids)...
  15. BIOTRANSFORMATION OF CANNABINOIDS BY MICROORGANISMS
    Larry Robertson; Fiscal Year: 1980
    ..Particular emphasis will be placed on the mono- and dihydroxylated metabolites, carboxylic acids and hydroxy acids which are difficult to produce by conventional organic synthetic methods...
  16. Arthropod-Based Libraries for High Throughput Screening
    Frank Schroeder; Fiscal Year: 2009
    ..While many of the compounds we have characterized have simple structures (such as straight chain alkenes, carboxylic acids, aldehydes, phenols, benzoquinones), there are also many examples of biologically active alkaloids, ..
  17. Peptidomimetics of D-Ala-D-Ala as Novel Antibacterials
    Norma Dunlap; Fiscal Year: 2003
    ..Tetrazoles have been used successfully as bioisosteric replacements for the carboxylic acids in a number of drugs. An example is the angiotensin receptor antagonist Losartan...
  18. Azides as Synthons for Isonitriles: Facilitating Challenging Coupling Reactions
    JENNIFER LYNN STOCKDILL; Fiscal Year: 2010
    ..improvements to the efficacy of the previously described two-component coupling of isonitriles with carboxylic acids to access primary and secondary amide derivatives...
  19. CNS DELIVERY OF ALKANOATE ANTIEPILEPTICS
    Danny Shen; Fiscal Year: 1999
    ..and blood-cerebrospinal fluid (CSF) barriers is mediated by membrane transport carriers for endogenous carboxylic acids, (2) individual differences in the physiologic regulation of these transport processes accounts for the ..
  20. Supercritical carbon dioxide for drying and sterilizing parenteral dosage forms
    Charles Decedue; Fiscal Year: 2009
    ..g., alcohols, amines, thiols, carboxylic acids, etc.) that may prove susceptible to damage...
  21. CHEMICAL SENSORY IRRITATION--CONTRAST WITH OLFACTION
    J Cometto Muniz; Fiscal Year: 1999
    ..Stimuli will comprise homologous series of compounds (e.g., aldehydes, carboxylic acids, terpenes). Physicochemical properties change systematically in such series...
  22. SODIUM CHANNEL GATING IN MODELS OF MYOTONIA
    Robert Ruff; Fiscal Year: 1991
    ..will be produced by: 1) bathing a fiber in a chloride- deficient solution, 2) treating fibers with aromatic carboxylic acids to reduce chloride conductance, and 3) treating rats with 20, 25-diazacholesterol...
  23. ACYLCOA FORMATION--COVALENT BINDING, PHARMACOKINETICS
    Leslie Benet; Fiscal Year: 2002
    ..inhibitors, with respect to acyl glucuronidation and acyl-CoA formation, on the covalent binding of selected carboxylic acids to protein; 3) To quantitatively determine and compare the levels of drug-protein acylation, acyl ..
  24. UDP-Glucuronic Acid Regeneration System
    INMAR MUNIR; Fiscal Year: 2004
    ..toward compounds with a wide variety of chemical structures, such as amines, hydroxylated compounds, and carboxylic acids. Therefore, phase II metabolism (conjugation) is often independent of phase I (functionalization) metabolic ..
  25. Dynamic Metabolomics via Isotopomer Analysis
    Henri Brunengraber; Fiscal Year: 2006
    ..for the concentration and mass isotopomer distribution of metabolites (acyl-CoAs, acylcarnitines, aminoacids, carboxylic acids, as well as intermediates of glycolysis, the pentosephosphate pathway, and the citric acid cycle) extracted ..
  26. Incorporating Thyronamines into Thyroid Hormone Metabolism
    WARREN WOOD; Fiscal Year: 2006
    ..Again the enzymes for the proposed transformations are present in the liver. An extraction for carboxylic acids followed by chromatographic separation of the products and comparison to triiodothyroacetic acid and other ..
  27. The Molecular Recognition of Wine and Urine
    Eric Anslyn; Fiscal Year: 2005
    ..We propose to target five classes of analytes: carboxylic acids, sugars, pectins, tannins, and gluoconorides. These classes present different challenges for fingerprinting...
  28. IONIC PROPERTIES OF SKELETAL MUSCLE MEMBRANES
    PAUL HOROWICZ; Fiscal Year: 1992
    ..In addition, the effects on Cl- movements of inorganic anions of the lyotropic series and various aromatic carboxylic acids will be studied at various external pHs, (Cl-)o, and membrane potentials and after chemical modification...
  29. MIXTURE TERATOGENESIS--RELATION TO MECHANISMS AND QSARS
    DOUGLAS DAWSON; Fiscal Year: 1992
    ..Each group of chemicals: 1) osteolathyrogens, 2) short-chain carboxylic acids (SCCAs), is thought to represent a different, distinct mode of teratogenesis...
  30. PYRUVATE ETHYL ESTER AS TREATMENT FOR REPERFUSION INJURY
    Alfred Ajami; Fiscal Year: 2000
    ..Esterified carboxylic acids, structurally related to pyruvate, can form stable solutions in the presence of calcium (or magnesium) ions ..
  31. Biosynthesis of hybrid peptide-polyketide antibiotics
    Ben Shen; Fiscal Year: 2007
    ..Hybrid NRPS-PKS systems will allow the production of novel metabolites by incorporating both amino acids and carboxylic acids, greatly expanding the size and structural diversity of resulting combinatorial biosynthetic libraries...
  32. SYNTHESIS OF SELECTIVE DEHYDROGENASE INHIBITORS
    EUGENE COATS; Fiscal Year: 1980
    The synthesis of 6-R-4-hydroxy-1,2,3,4-tetrahydroquinoline-3-carboxylic acids and 6-R-1,2,3,4-tetrahydroquinoline-3,4-dicarboxylic acids is proposed...
  33. MOLECULAR RECOGNITION IN NUCLEAR PROTEIN TRANSPORT
    ROBERT STANDAERT; Fiscal Year: 2002
    ..Novel, photochemically regulatable amino acids and carboxylic acids will be employed to generate mutants of native signals that bind karyopherin in a photo-regulated manner...
  34. Detection of Protein Carboxylic Esters
    JOSHUA ALFARO; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Esterification of protein carboxylic acids results in a myriad of biological functions. Such modifications generally are reversible. As such, the esterification states are often dynamic...
  35. Staining Techniques for Micro-CT Imaging of Microdamage
    RYAN ROEDER; Fiscal Year: 2004
    ..Identify one or more metal chelating agents having two or more carboxy functional groups (multi-functional carboxylic acids or proteins) that will chelate with both calcium in bone and one or more heavy metal ions which act as a ..
  36. Metalloporphyrin hosts in structural studies by CD/FDCD
    Gloria Proni; Fiscal Year: 2003
    ..strategy for absolute stereochemical determination of mono-substituted secondary amines, primary alcohols and carboxylic acids. I propose to derivative these compounds with an alchiral diamine reagent which would function as a carrier ..
  37. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  38. FORMIC ACID-WATER OXYGEN EXCHANGE KINETICS
    RICHARD REDINGTON; Fiscal Year: 1980
    ..Oxygen exchange between water and other molecules, and vibrational analysis of formic and other carboxylic acids, are also of interest...
  39. CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTION
    J Enrique Cometto Muniz; Fiscal Year: 2010
    ..The outcome will allow us to make inferences about the relative breadth of chemical tuning in human olfaction and chemesthesis. ..
  40. Molecular Boundaries For Trigeminal Chemosensory Impact
    J Cometto Muniz; Fiscal Year: 2006
    ..abstract_text> ..
  41. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  42. Synthesis of Polyketides and Terpenes
    David A Evans; Fiscal Year: 2010
    ..As a consequence, organic synthesis is a critical discipline that continues to have an important impact on the fields of both medicine and biology. ..
  43. SYNTHESIS OF THE TEDANOLIDES, CYTOTOXIC POLYPROPIONATES
    Michael Jung; Fiscal Year: 2003
    ....
  44. ASYMMETRIC SYNTHESIS OF VANCOMYCIN ANTIBIOTICS
    David Evans; Fiscal Year: 2001
    ..During the course of this project we intend to confirm (correct) the absolute stereochemical assignments of the principal members of this family by total synthesis. ..
  45. ACCELERATING IRON CHELATION FROM SERUM TRANSFERRIN
    WESLEY HARRIS; Fiscal Year: 2004
    ..This is a collaborative project involving faculty with expertise in molecular biology, solution kinetics, organic synthesis, and computational chemistry. ..
  46. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  47. Perfluorocarbon Materials As Drug Delivery Vehicles
    Hans Joachim Lehmler; Fiscal Year: 2004
    ..abstract_text> ..
  48. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  49. ASYMMETRIC SYNTHESIS OF IONOPHORE/MACROLIDE ANTIBIOTICS
    David Evans; Fiscal Year: 2005
    ..Our goal has been to set in place all of the reactions necessary for the rapid assemblage of any polyketide target structure. ..
  50. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND BERGERON; Fiscal Year: 2004
    ....
  51. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  52. Biomimetic Studies of NO-binding Respiratory Chain Hemes
    JAMES COLLMAN; Fiscal Year: 2008
    ..An emphasis will be placed on kinetic and mechanistic studies to elucidate the putitive reaction pathways of CcO and NOR. ..
  53. Distribution of PCB Atropisomers
    Hans Joachim Lehmler; Fiscal Year: 2008
    ..The long term career goal is to establish Dr. Lehmler as an investigator with independent research status and funding. ..
  54. Desferrithiocin Analogue Actinide Decorporation Agents
    RAYMOND BERGERON; Fiscal Year: 2008
    ..abstract_text> ..
  55. Functional active-site models of cytochrome c oxidase
    JAMES COLLMAN; Fiscal Year: 2009
    ..The role that the copper ion (CuB) and a phenolic group, in the amino acid tyrosine (Tyr244) play in the catalytic function of CcO are of particular interest. ..
  56. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  57. OLFACTORY FUNCTION IN GENE-TARGETED MICE
    Burton Slotnick; Fiscal Year: 2002
    ..A final report of these studies will incorporate a detailed description of apparatus, methods protocol and files of raw data and summary statistics presented in database and spreadsheet format. ..
  58. Open Tubular Capillary Electrochromatography/Mass Spectroscopy
    JOSEPH PESEK; Fiscal Year: 2007
    ..This project focuses on providing a means for the analysis of complex samples found in clinical, biological and pharmaceutical applications. [unreadable] [unreadable] [unreadable]..
  59. MECHANISMS OF NUCLEAR IMPORT
    Larry Gerace; Fiscal Year: 2006
    ..Thus, understanding basic nuclear transport mechanisms can provide a framework for developing new therapeutic approaches relevant to viral pathogenesis, cancer and immunity and other processes. ..
  60. Cross-Coupling Reactions of Organosilanols
    SCOTT DENMARK; Fiscal Year: 2009
    ..Synthetic approaches to isodomoic acid H, hepatitis C viral inihibiting indole alkaloids, the salicylihalimide macrolactone oximidine II, and polyene antiviral antibiotic viridenomycin are detailed. ..
  61. IN VITRO EVOLUTION OF NEW MOLECULAR FUNCTIONS
    Jack Szostak; Fiscal Year: 2003
    ..The re-use of previously selected functions to evolve new functions will also be studied. The idea that proteins are better than RNA at evolving new functions from existing functions will also be tested. ..