carboxylic acids

Summary

Summary: Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.

Top Publications

  1. ncbi The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
    Andrew J Brown
    Department of 7TMR Systems Research, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom
    J Biol Chem 278:11312-9. 2003
  2. doi Metabolic engineering of Saccharomyces cerevisiae for production of carboxylic acids: current status and challenges
    Derek A Abbott
    Department of Biotechnology, Delft University of Technology, Delft, The Netherlands
    FEMS Yeast Res 9:1123-36. 2009
  3. ncbi Simultaneous determination of soluble sugars and organic acids as their trimethylsilyl derivatives in apricot fruits by gas-liquid chromatography
    F Bartolozzi
    Departimento di Colture Arboree, , Italy
    J Chromatogr A 758:99-107. 1997
  4. ncbi Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria
    B J Kroesen
    Departments of Pathology and Laboratory Medicine, University Hospital Groningen, 9713 G2 Groningen, The Netherlands
    J Biol Chem 276:13606-14. 2001
  5. doi Method for rapid detection of the PvCesA3 gene allele conferring resistance to mandipropamid, a carboxylic acid amide fungicide, in Plasmopara viticola populations
    Yoshinao Aoki
    The Institute of Enology and Viticulture, University of Yamanashi, Kofu, Yamanashi, Japan
    Pest Manag Sci 67:1557-61. 2011
  6. pmc 2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases
    Pinhong Chen
    Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, United States
    Bioorg Med Chem Lett 22:6229-32. 2012
  7. ncbi A single point mutation in the novel PvCesA3 gene confers resistance to the carboxylic acid amide fungicide mandipropamid in Plasmopara viticola
    Mathias Blum
    Institute of Botany, University of Basel, Basel, Switzerland
    Fungal Genet Biol 47:499-510. 2010
  8. ncbi 5-Phenyl substituted 1-methyl-2-pyridones and 4'-substituted biphenyl-4-carboxylic acids. synthesis and evaluation as inhibitors of steroid-5alpha-reductase type 1 and 2
    Franck Picard
    8 5 Pharmaceutical and Medicinal Chemistry, Saarland University, PO Box 15 11 50, D 66041, Saarbrucken, Germany
    Bioorg Med Chem 10:437-48. 2002
  9. ncbi Presence and partitioning behavior of polyfluorinated iodine alkanes in environmental matrices around a fluorochemical manufacturing plant: another possible source for perfluorinated carboxylic acids?
    Ting Ruan
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085
    Environ Sci Technol 44:5755-61. 2010
  10. ncbi Breaking through the acid barrier: an orchestrated response to proton stress by enteric bacteria
    J P Audia
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688, USA
    Int J Med Microbiol 291:97-106. 2001

Detail Information

Publications267 found, 100 shown here

  1. ncbi The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
    Andrew J Brown
    Department of 7TMR Systems Research, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom
    J Biol Chem 278:11312-9. 2003
    ..The identity of the cognate physiological ligands for these receptors is not clear, although propionate is known to occur in vivo at high concentrations under certain pathophysiological conditions...
  2. doi Metabolic engineering of Saccharomyces cerevisiae for production of carboxylic acids: current status and challenges
    Derek A Abbott
    Department of Biotechnology, Delft University of Technology, Delft, The Netherlands
    FEMS Yeast Res 9:1123-36. 2009
    ..In addition to recent progress in engineering S. cerevisiae for organic acid production, the key limitations and challenges are discussed in the context of sustainable industrial production of organic acids from renewable feedstocks...
  3. ncbi Simultaneous determination of soluble sugars and organic acids as their trimethylsilyl derivatives in apricot fruits by gas-liquid chromatography
    F Bartolozzi
    Departimento di Colture Arboree, , Italy
    J Chromatogr A 758:99-107. 1997
    ....
  4. ncbi Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria
    B J Kroesen
    Departments of Pathology and Laboratory Medicine, University Hospital Groningen, 9713 G2 Groningen, The Netherlands
    J Biol Chem 276:13606-14. 2001
    ....
  5. doi Method for rapid detection of the PvCesA3 gene allele conferring resistance to mandipropamid, a carboxylic acid amide fungicide, in Plasmopara viticola populations
    Yoshinao Aoki
    The Institute of Enology and Viticulture, University of Yamanashi, Kofu, Yamanashi, Japan
    Pest Manag Sci 67:1557-61. 2011
    ..The occurrence of carboxylic acid amide (CAA)-fungicide-resistant Plasmopara viticola populations is becoming a serious problem in the control of grapevine downy mildew worldwide...
  6. pmc 2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases
    Pinhong Chen
    Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, United States
    Bioorg Med Chem Lett 22:6229-32. 2012
    ..We report several 2-substituted 4,5-dihydrothiazole-4-carboxylic acids to be novel MBL inhibitors...
  7. ncbi A single point mutation in the novel PvCesA3 gene confers resistance to the carboxylic acid amide fungicide mandipropamid in Plasmopara viticola
    Mathias Blum
    Institute of Botany, University of Basel, Basel, Switzerland
    Fungal Genet Biol 47:499-510. 2010
    ..Our data demonstrate that the identified genes are putative cellulose synthases and that one recessive mutation in PvCesA3 causes inheritable resistance to the CAA fungicide mandipropamid...
  8. ncbi 5-Phenyl substituted 1-methyl-2-pyridones and 4'-substituted biphenyl-4-carboxylic acids. synthesis and evaluation as inhibitors of steroid-5alpha-reductase type 1 and 2
    Franck Picard
    8 5 Pharmaceutical and Medicinal Chemistry, Saarland University, PO Box 15 11 50, D 66041, Saarbrucken, Germany
    Bioorg Med Chem 10:437-48. 2002
    The synthesis of a series of 5-phenyl substituted 1-methyl-2-pyridones (I) and 4'-substituted biphenyl-4-carboxylic acids (II) as novel A-C ring steroidomimetic inhibitors of 5alpha-reductase (5alphaR) is described...
  9. ncbi Presence and partitioning behavior of polyfluorinated iodine alkanes in environmental matrices around a fluorochemical manufacturing plant: another possible source for perfluorinated carboxylic acids?
    Ting Ruan
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085
    Environ Sci Technol 44:5755-61. 2010
    ....
  10. ncbi Breaking through the acid barrier: an orchestrated response to proton stress by enteric bacteria
    J P Audia
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688, USA
    Int J Med Microbiol 291:97-106. 2001
    ..In addition, we will review three dedicated acid resistance systems of E. coli, not present in Salmonella, that allow this organism to survive extreme (pH 2) acid challenge...
  11. doi Response to zinc deficiency of two rice lines with contrasting tolerance is determined by root growth maintenance and organic acid exudation rates, and not by zinc-transporter activity
    Basuki Widodo
    Japan International Research Center for Agricultural Sciences JIRCAS, 1 1 Ohwashi, 305 8686 Tsukuba, Japan
    New Phytol 186:400-14. 2010
    ..Zinc-deficiency tolerance in RIL46 is most likely the result of maintenance of root growth, increased efflux of Zn ligands, and increased uptake of Zn-ligand complexes at low [Zn](ext); these traits are potential breeding targets...
  12. doi Mandipropamid targets the cellulose synthase-like PiCesA3 to inhibit cell wall biosynthesis in the oomycete plant pathogen, Phytophthora infestans
    Mathias Blum
    Syngenta Crop Protection AG, CH 4332 Stein, Switzerland
    Mol Plant Pathol 11:227-43. 2010
    ..The transformation and expression of a mutated PiCesA3 allele was carried out in a sensitive wild-type isolate to demonstrate that the mutations in PiCesA3 were responsible for the MPD insensitivity phenotype...
  13. ncbi Cytotoxic C47-polyacetylene carboxylic acids from a marine sponge Pertrosia sp
    Chikane Okamoto
    Laboratory of Aquatic Natural Products Chemistry, Garaduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    J Nat Prod 70:1816-9. 2007
    Two new polyacetylene carboxylic acids, petroformynic acids B (3) and C (4), were isolated from a marine sponge Pertrosia sp. as cytotoxic constituents...
  14. ncbi Analogues of neuropeptide Y containing beta-aminocyclopropane carboxylic acids are the shortest linear peptides that are selective for the Y1 receptor
    Norman Koglin
    Institut fur Biochemie, Universitat Leipzig, Talstrasse 33, 04103 Leipzig, Germany
    Angew Chem Int Ed Engl 42:202-5. 2003
  15. ncbi Copper complexes of nicotinic-aromatic carboxylic acids as superoxide dismutase mimetics
    Thummaruk Suksrichavalit
    Department of Clinical Microbiology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
    Molecules 13:3040-56. 2008
    ..This study reports the synthesis of novel mixed ligand complexes of copper with nicotinic and other select carboxylic acids (phthalic, salicylic and anthranilic acids)...
  16. ncbi Sequential ethoxycarbonylation, methoximation and tert-butyldimethylsilylation for simultaneous determination of amino acids and carboxylic acids by dual-column gas chromatography
    Man Jeong Paik
    College of Pharmacy, Sungkyunkwan University, Suwon, Kyunggi Do 440 746, South Korea
    J Chromatogr A 1034:13-23. 2004
    ..on dual-columns with different polarities, which provided simultaneous separation of multiple amino acids, carboxylic acids (CAs) and keto acids, facilitating accurate peak confirmation based on matching with retention index sets ..
  17. ncbi Structure-activity relationship between carboxylic acids and T cell cycle blockade
    Kathleen M Gilbert
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences Arkansas Children s Hospital Research Institute, Little Rock, 72202, USA
    Life Sci 78:2159-65. 2006
    This study was designed to examine the potential structure-activity relationship between carboxylic acids, histone acetylation and T cell cycle blockade...
  18. ncbi Prediction of pKa values for aliphatic carboxylic acids and alcohols with empirical atomic charge descriptors
    Jinhua Zhang
    Computer Chemie Centrum and Institut für Organische Chemie, Universitat Erlangen Nurnberg, Nagelsbachstrasse 25, D 91052, Erlangen, Germany
    J Chem Inf Model 46:2256-66. 2006
    Two quantitative pKa prediction models for aliphatic carboxylic acids and for alcohols were developed by multiple linear-regression (MLR) analysis with empirical atomic descriptors...
  19. ncbi Development of an HPLC-fluorescence determination method for carboxylic acids related to the tricarboxylic acid cycle as a metabolome tool
    Kazuyuki Kubota
    Laboratory of Bio Analytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biomed Chromatogr 19:788-95. 2005
    We report the simultaneous determination of the carboxylic acids related to the tricarboxylic acid (TCA) cycle, which plays an important role in producing adenosine triphosphate (ATP) and generating energy in mitochondria...
  20. ncbi Lupane-triterpene carboxylic acids from the leaves of Acanthopanax trifoliatus
    Phan Van Kiem
    Institute of Natural Products Chemistry, NCST, Caugiay, Hanoi, Vietnam
    Chem Pharm Bull (Tokyo) 51:1432-5. 2003
    Two new lupane-triterpene carboxylic acids, called acantrifoic acid A (1) and acantrifoside C (2) have been isolated from the leaves of Acanthopanax trifoliatus...
  21. doi Simultaneous analysis of amino acids and carboxylic acids by capillary electrophoresis-mass spectrometry using an acidic electrolyte and uncoated fused-silica capillary
    Masataka Wakayama
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Anal Chem 82:9967-76. 2010
    ..spectrometry (CE-MS) method is demonstrated for the simultaneous analysis of amino acids and small carboxylic acids (glycerate, lactate, fumarate, succinate, malate, tartrate, citrate, iso-citrate, cis-aconitate, and ..
  22. ncbi Induction of the mitochondrial permeability transition in vitro by short-chain carboxylic acids
    C M Palmeira
    Department of Biochemistry and Molecular Biology, University of Minnesota School of Medicine, Duluth 55812, USA
    Biochem Biophys Res Commun 272:431-5. 2000
    ..of the present investigation was to determine if induction of the MPT is a general response to short-chain carboxylic acids or if there are critical physical chemical parameters for this response...
  23. doi Fermentation of sugarcane bagasse and chicken manure to calcium carboxylates under thermophilic conditions
    Zhihong Fu
    Department of Microbiology and Cell Science, Florida Center for Renewable Chemicals and Fuels, University of Florida, PO Box 110700, Gainesville, FL 32611 0700, USA
    Appl Biochem Biotechnol 162:561-78. 2010
    Sugarcane bagasse and chicken manure were anaerobically fermented to carboxylic acids using a mixed culture of marine microorganisms at 55 degrees C...
  24. doi Direct amidation of carboxylic acids catalyzed by ortho-iodo arylboronic acids: catalyst optimization, scope, and preliminary mechanistic study supporting a peculiar halogen acceleration effect
    Nicolas Gernigon
    Department of Chemistry, University of Alberta, Gunning Lemieux Chemistry Centre, Edmonton, Alberta, T6G 2G2, Canada
    J Org Chem 77:8386-400. 2012
    ..and synthetic products motivates the development of catalytic, direct amidation methods employing free carboxylic acids and amines that circumvent the need for stoichiometric activation or coupling reagents...
  25. ncbi Malate exudation by six aerobic rice genotypes varying in zinc uptake efficiency
    Xiaopeng Gao
    Key Laboratory of Plant Soil Interactions, MOE, Beijing, PR China
    J Environ Qual 38:2315-21. 2009
    ..The results also emphasize that effects of root exudates on soil properties need to be assessed to evaluate the role of root exudation in nutrient mobilization...
  26. doi The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors
    Yibin Xiang
    Department of Medicinal Chemistry, Drug and Biomaterial R and D, Genzyme Corp, 153 Second Avenue, Waltham, MA 02451, USA
    Bioorg Med Chem Lett 21:3050-6. 2011
    Novel benzofuran-2-carboxylic acids, exemplified by 29, 38 and 39, have been discovered as potent Pim-1 inhibitors using fragment based screening followed by X-ray structure guided medicinal chemistry optimization...
  27. pmc The antimutagenicity of 2-substituted selenazolidine-4-(R)-carboxylic acids
    Wael M El-Sayed
    University of Utah, Department of Pharmacology and Toxicology, Salt Lake City, UT 84112, USA
    Mutat Res 627:136-45. 2007
    ..Selenazolidine-4-(R)-carboxylic acids (SCAs) were devised as prodrugs of L-selenocysteine, to provide selenium in a form and at a concentration ..
  28. ncbi Conversion of sugarcane bagasse to carboxylic acids using a mixed culture of mesophilic microorganisms
    Piyarat Thanakoses
    Department of Chemical Engineering, 3122 TAMU, Texas A and M University, College Station, TX 77843 3122, USA
    Appl Biochem Biotechnol 105:523-46. 2003
    Using the MixAlco process, biomass can be converted into carboxylic acids, which can be chemically converted into mixed alcohol fuels...
  29. doi 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b
    Philip J Skinner
    Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA, 92121, USA
    Bioorg Med Chem Lett 19:4207-9. 2009
    A series of 5-N,N-disubstituted-5-aminopyrazole-3-carboxylic acids were prepared and found to act as highly potent and selective agonists of the G-Protein Coupled Receptor (GPCR) GPR109b, a low affinity receptor for niacin and some ..
  30. ncbi Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease
    Brian J Lipworth
    Department of Medicine and Therapeutics, Asthma and Allergy Research Group, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Lancet 365:167-75. 2005
    ..Ultimately, clinicians will want to know whether PDE4 inhibitors are anything more than expensive "designer" theophylline, the archetypal non-selective phosphodiesterase inhibitor...
  31. doi High capacity hydrogen adsorption in Cu(II) tetracarboxylate framework materials: the role of pore size, ligand functionalization, and exposed metal sites
    Xiang Lin
    School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    J Am Chem Soc 131:2159-71. 2009
    ..However, although increasing the overlap of potential energy fields of pore walls increases the heat of H2 adsorption at low pressure, it may be detrimental to the overall adsorption capacity by reducing the pore volume...
  32. ncbi 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b
    Graeme Semple
    J Med Chem 49:1227-30. 2006
    1-Substituted benzotriazole carboxylic acids have been identified as the first reported examples of selective small-molecule agonists of the human orphan G-protein-coupled receptor GPR109b (HM74), a low-affinity receptor for the HDL-..
  33. doi Enaminones as building blocks in heterocyclic syntheses: reinvestigating the product structures of enaminones with malononitrile. A novel route to 6-substituted-3-oxo-2,3-dihydropyridazine-4-carboxylic acids
    Abdul aziz Alnajjar
    Applied Science Department, College of Technological Studies, Public Authority for Applied Education and Training, Safat, Kuwait
    Molecules 14:68-77. 2009
    ..A novel route to 2,3-dihydropyridazine-4-carboxylic acids 4a-c via reactions of 2-cyano-5-(dimethylamino)-5-arylpenta-2,4-dienamides 8a-c with nitrous acid or with ..
  34. ncbi High performance column liquid chromatographic analysis of selected carboxylic acids in Biomphalaria glabrata patently infected with Schistosoma mansoni
    Daniel R Massa
    Department of Chemistry, Lafayette College, Easton, PA 18042, USA
    Parasitol Res 101:925-8. 2007
    ..chromatography (HPLC) was used to determine the effects of a patent Schistosoma mansoni infection on certain carboxylic acids in the digestive gland gonad complex (DGG) and hemolymph of Biomphalaria glabrata...
  35. ncbi Conversion of municipal solid wastes to carboxylic acids by thermophilic fermentation
    Wen Ning Chan
    Department of Chemical Engineering, Texas A and M University, College Station, TX 77843 3122, USA
    Appl Biochem Biotechnol 111:93-112. 2003
    The purpose of this research is to generate carboxylic acids from the biodegradable fraction of municipal solid wastes (MSW) and municipal sewage sludge (MSS) by using a thermophilic (55 degrees C), anaerobic, high-solid fermentation...
  36. ncbi Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors
    Motohide Sato
    Central Pharmaceutical Research Institute, JT Inc, 1 1 Murasaki cho, Takatsuki, Osaka, 569 1125, Japan
    J Med Chem 52:4869-82. 2009
    ..Here, we show the synthesis and the detailed structure-activity relationship of the quinolone carboxylic acids as a novel monoketo acid class of integrase inhibitors...
  37. ncbi The kinetics of photocatalytic degradation of aliphatic carboxylic acids in an UV/TiO2 suspension system
    Q Chen
    College of Atmospheric Sciences, Lanzhou University, Lanzhou, China
    Environ Technol 30:1103-9. 2009
    Kinetic studies on the photocatalytic degradation of aliphatic carboxylic acids were carried out in a slurry photoreactor with in-situ monitoring, employing artificial UV light as the source of energy and nano-TiO2 powder as the catalyst...
  38. pmc Carboxylic acids as biomarkers of Biomphalaria alexandrina snails infected with Schistosoma mansoni
    Salwa M F Abou Elseoud
    Parasitology Department, Ain Shams University, Cairo, Egypt
    Korean J Parasitol 48:127-32. 2010
    ..Quantification of carboxylic acids, using HPLC strategy, was fast, easy, and accurate in prediction of infected and uninfected snails and ..
  39. ncbi Determining the molecular interactions of perfluorinated carboxylic acids with human sera and isolated human serum albumin using nuclear magnetic resonance spectroscopy
    Jessica C D'eon
    Department of Chemistry, University of Toronto, Toronto, Ontario, M5S 3H6 Canada
    Environ Toxicol Chem 29:1678-88. 2010
    ..Perfluorohexanoic acid (PFHxA) and PFOA were used as model perfluorinated carboxylic acids (PFCAs) to characterize the major site of PFCA interaction in human sera...
  40. pmc Structure-activity relationships on the odor detectability of homologous carboxylic acids by humans
    J Enrique Cometto-Muniz
    Chemosensory Perception Laboratory, Department of Surgery Otolaryngology, University of California, San Diego, 9500 Gilman Dr, Mail Code 0957, La Jolla, CA 92093 0957, USA
    Exp Brain Res 207:75-84. 2010
    ..We discuss the mechanistic implications of this model for the process of olfactory detection...
  41. pmc Evaluation of toxic effects of several carboxylic acids on bacterial growth by toxicodynamic modelling
    Jose Antonio Vazquez
    Grupo de Reciclado e Valorización de Materiais Residuais REVAL, Instituto de Investigacions Marinas CSIC, r Eduardo Cabello, 6, Vigo 36208, Galicia, Spain
    Microb Cell Fact 10:100. 2011
    ..However, they typically provide only descriptive information without modelling the influence of acid concentrations on bacterial kinetics...
  42. doi Rapid synthesis of 1,3,5-substituted 1,2,4-triazoles from carboxylic acids, amidines, and hydrazines
    Georgette M Castanedo
    Discovery Chemistry Group, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    J Org Chem 76:1177-9. 2011
    A general method for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed from reaction of carboxylic acids, primary amidines, and monosubstituted hydrazines...
  43. ncbi Neurochemical analysis of amino acids, polyamines and carboxylic acids: GC-MS quantitation of tBDMS derivatives using ammonia positive chemical ionization
    Paul L Wood
    The Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, 1801 Maple Avenue, Suite 4306, Evanston, IL 60201, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 831:313-9. 2006
    ..Previous workers have utilized this derivative for GC-MS analyses of amino acids, carboxylic acids and urea with electron impact (EI) and with positive chemical ionization (PCI; methane as reagent gas)...
  44. ncbi A new synthesis of indole 5-carboxylic acids and 6-hydroxy-indole-5-carboxylic acids in the preparation of an o-hydroxylated metabolite of vilazodone
    Timo Heinrich
    Merck KGaA, Preclinical Pharmaceutical Research, Frankfurter Str 250, 64293 Darmstadt, Germany
    Bioorg Med Chem Lett 14:2681-4. 2004
    ..Functional group interconversion of carboxylic acid via carboxamide into cyanide was performed with methanesulfonic acid chloride...
  45. ncbi Regiocontrolled intramolecular cyclizations of carboxylic acids to carbon-carbon triple bonds promoted by acid or base catalyst
    Masanobu Uchiyama
    Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba ku, Sendai 980 8578, Japan
    Org Lett 8:5517-20. 2006
    ..time, the relationship between regioselectivity and acid/base effects in the cyclization reactions between carboxylic acids and carbon-carbon triple bonds...
  46. ncbi Analysis of carboxylic acids in biological fluids by capillary electrophoresis
    Beatriz Baena
    Sección Química Analítica, Fac CC Experimentales y de la Salud, Universidad San Pablo CEU, Madrid, Spain
    Electrophoresis 26:2622-36. 2005
    ..The use of microchip devices and CE-MS couplings for organic acid analysis is also discussed...
  47. ncbi Synthesis and antiprotozoan evaluation of new alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids
    Julieta Coro
    Laboratorio de Síntesis Orgánica, Facultad de Quimica, Universidad de La Habana, 10400 Ciudad Habana, Cuba
    Bioorg Med Chem 13:3413-21. 2005
    Two new series of several alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids were synthesized in a two step procedure from the corresponding alkyl bis-dithiocarbamic salt intermediary...
  48. ncbi Accurate pK(a) calculations for carboxylic acids using complete basis set and Gaussian-n models combined with CPCM continuum solvation methods
    M D Liptak
    Contribution from the Department of Chemistry, Hamilton College, 198 College Hill Road, Clinton, New York 13323, USA
    J Am Chem Soc 123:7314-9. 2001
    ..and Gaussian-n methods were combined with CPCM continuum solvation methods to calculate pK(a) values for six carboxylic acids. An experimental value of -264...
  49. ncbi The pKa values of PFOA and other highly fluorinated carboxylic acids
    Kai Uwe Goss
    UFZ Helmholtz Centre for Environmental Research, Permoserstr 15, 04318 Leipzig, Germany
    Environ Sci Technol 42:456-8. 2008
    ..Here, the correct value is estimated to be close to -0.5 based on analogy considerations and molecular modeling. Calculated pKa values for other highly fluorinated carboxylic acids are also presented.
  50. doi Dual effects of aliphatic carboxylic acids on cresolase and catecholase reactions of mushroom tyrosinase
    N Gheibi
    Department of Physiology and Medical Physics, Qazvin University of Medical Sciences, Qazvin, Iran
    J Enzyme Inhib Med Chem 24:1076-81. 2009
    ..Thus, they could completely block the cresolase reaction, by preventing monophenol binding to the enzyme. From an allosteric point of view, n-alkyl acids may be involved in activation of MT catecholase reactions...
  51. ncbi Synthesis and potassium channel opening activity of substituted 10H-benzo[4,5]furo[3,2-b]indole-and 5,10-dihydro-indeno[1,2-b]indole-1-carboxylic acids
    J A Butera
    Medicinal Chemistry, Chemical Sciences, Wyeth Ayerst Research, CN 8000, Princeton, NJ 08543, USA
    Bioorg Med Chem Lett 11:2093-7. 2001
    Compounds in a structurally novel series of substituted 10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acids and related 5,10-dihydro-indeno[1,2-b]indole-1-carboxylic acids were prepared and shown to possess potent, bladder-selective smooth ..
  52. ncbi N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors
    Tjeerd Barf
    Department of Medicinal Chemistry, Biovitrum AB, Research, 112 76 Stockholm, Sweden
    Bioorg Med Chem Lett 19:1745-8. 2009
    ..This led to the identification of a potent and selective class of A-FABP inhibitors as illustrated by N-benzyl-hexahydrocyclohepta[b]indole 30...
  53. ncbi A fluorogenic reagent, 4-mercapto-7-methylthio-2,1,3-benzoxadiazole for carboxylic acids, designed by prediction of the fluorescence intensity
    S Uchiyama
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
    Anal Chem 73:2165-70. 2001
    ..we previously proposed 7-acetylamino-4-mercapto-2,1,3-benzoxadiazole (AABD-SH) as a fluorogenic reagent for carboxylic acids. Since then, progress has made it possible to estimate the fluorescence quantum yields of the 4,7-..
  54. ncbi Sesquiterpene carboxylic acids from a wild tomato species affect larval feeding behavior and survival of Helicoverpa zea and Spodoptera exigua (Lepidoptera: Noctuidae)
    J E Frelichowski
    Department of Natural Resources and Environmental Science, University of Illinois, Urbana 61801, USA
    J Econ Entomol 94:1249-59. 2001
    The sesquiterpene carboxylic acids (SCA), (+)-(E)-alpha-santalen-12-oic, (-)-(E)-endo-alpha-bergamoten-12-oic, and (+)-(E)-endo-beta-bergamoten-12-oic acid, are produced in glandular trichomes of Lycopersicon hirsutum f. typicum Humb...
  55. ncbi Determination of carboxylic acids, carbohydrates, glycerol, ethanol, and 5-HMF in beer by high-performance liquid chromatography and UV-refractive index double detection
    M Castellari
    Istituto di Industrie Agrarie, Universita degli Studi di Bologna, Italy
    J Chromatogr Sci 39:235-8. 2001
    A high-performance liquid chromatographic method is proposed for the simultaneous separation of main carboxylic acids, carbohydrates, ethanol, glycerol, and 5-HMF in beer by direct injection...
  56. ncbi Role of chromatography in the analysis of sugars, carboxylic acids and amino acids in food
    I Molnar-Perl
    Institute of Inorganic and Analytical Chemistry, L Eotvos University, Budapest, Hungary
    J Chromatogr A 891:1-32. 2000
    An overview is presented of chromatographic methods currently in use to determine sugars, carboxylic acids and amino acids in foods: high-performance liquid chromatography, gas chromatography and capillary electrophoresis...
  57. ncbi Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase
    S El Bawab
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, South Carolina 29425, USA
    J Biol Chem 276:16758-66. 2001
    ..The results are discussed in view of a possible regulation of this enzyme by the intracellular pH or by an interaction with cardiolipin and/or phosphatidic acid...
  58. ncbi Combinatorial receptor codes for odors
    B Malnic
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 96:713-23. 1999
    ..Our studies also indicate that slight alterations in an odorant, or a change in its concentration, can change its "code," potentially explaining how such changes can alter perceived odor quality...
  59. ncbi Selective phosphodiesterase-4 inhibitors in chronic obstructive lung disease
    Francisco J Soto
    Division of Pulmonary and Critical Care Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Curr Opin Pulm Med 11:129-34. 2005
    ..Novel anti-inflammatory therapies such as selective phosphodiesterase 4 (PDE4) inhibitors are in clinical development. Their potential role in the management of COPD is described in this review...
  60. doi Fluorinated alkyl compounds including long chain carboxylic acids in wild bird livers from Japan
    Keerthi S Guruge
    Safety Research Team, National Institute of Animal Health, National Agriculture and Food Research Organization, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    Chemosphere 83:379-84. 2011
    ..in a Japanese sparrowhawk, indicating that the top predatory wild birds can accumulate several long chain carboxylic acids. However, the current FAC concentrations found in livers may suggest that these compounds alone would not ..
  61. ncbi Fluorotelomer carboxylic acids and PFOS in rainwater from an urban center in Canada
    Mark Loewen
    Department of Fisheries and Oceans Canada, Freshwater Institute, Winnipeg, Manitoba, Canada
    Environ Sci Technol 39:2944-51. 2005
    A method based on LC/MS/MS analysis of fluorotelomer carboxylic acids (FTCAs: CnF2n+1CH2COOH, n = 6, 8, and 10) and fluorotelomer unsaturated carboxylic acids (FTUCAs: CnF2nCHCOOH, n = 6, 8, and 10) in rainwater using negative ionization ..
  62. pmc The effect of aliphatic carboxylic acids on olfaction-based host-seeking of the malaria mosquito Anopheles gambiae sensu stricto
    Renate C Smallegange
    Laboratory of Entomology, Wageningen University, PO Box 8031, Wageningen 6700 EH, The Netherlands
    J Chem Ecol 35:933-43. 2009
    The role of aliphatic carboxylic acids in host-seeking response of the malaria mosquito Anopheles gambiae sensu stricto was examined both in a dual-choice olfactometer and with indoor traps...
  63. ncbi Exceptional chiral recognition of racemic carboxylic acids by calix[4]arenes bearing optically pure alpha,beta-amino alcohol groups
    Yan Song Zheng
    Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, P R China
    Org Lett 6:1189-92. 2004
    ..structure: see text]..
  64. pmc Molecular receptive range variation among mouse odorant receptors for aliphatic carboxylic acids
    Sarah E Repicky
    Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida 33101, USA
    J Neurochem 109:193-202. 2009
    ..MOR23-1, MOR31-4, MOR32-11 and MOR40-4), which have previously been identified as receptors for aliphatic carboxylic acids. Each receptor was expressed in Xenopus oocytes, along with Galpha(olf) and the cystic fibrosis transmembrane ..
  65. ncbi Electroantennogram and behavioral responses of Culex quinquefasciatus (Diptera: Culicidae) females to chemicals found in human skin emanations
    Sarika N Puri
    Defense Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    J Med Entomol 43:207-13. 2006
    ..quinquefasciatus to various chemical components of human skin emanations (carboxylic acids, alcohols, and aldehydes) were evaluated separately at three doses (0.01, 0...
  66. ncbi Isoprene forms secondary organic aerosol through cloud processing: model simulations
    Ho Jin Lim
    Department of Environmental Sciences, Rutgers University, 14 College Farm Road, New Brunswick, New Jersey 08901, USA
    Environ Sci Technol 39:4441-6. 2005
    ..We conclude that cloud processing of isoprene is an important contributor to SOA production, altering the global distribution of hygroscopic organic aerosol and cloud condensation nuclei...
  67. ncbi Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis
    Shinji Mizuarai
    Tsukuba Research Institute, Banyu Pharmaceutical Co Ltd, Ibaraki, Japan
    J Biol Chem 280:32434-41. 2005
    ....
  68. doi The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors
    Tim Sparey
    Department of Medicinal Chemistry, Merck Sharp and Dohme, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK
    Bioorg Med Chem Lett 18:3386-91. 2008
    ..In parallel, analogues were prepared to survey the SARs of 1...
  69. ncbi Inhibition of airway hyperresponsiveness and pulmonary inflammation by roflumilast and other PDE4 inhibitors
    L Wollin
    ALTANA Pharma, Byk Gulden Strasse 2, 78467 Konstanz, Germany
    Pulm Pharmacol Ther 19:343-52. 2006
    ..This study suggests that roflumilast has anti-inflammatory action and provides rationale for the investigation of roflumilast in asthmatic patients...
  70. pmc Permeation of aromatic carboxylic acids across lipid bilayers: the pH-partition hypothesis revisited
    Anita V Thomae
    Department of Chemistry and Applied Biosciences, ETH Federal Institute of Technology, 8093 Zurich, Switzerland
    Biophys J 89:1802-11. 2005
    ..A recently developed permeation assay permits us to directly determine pH-dependent permeation of aromatic carboxylic acids. Tb(3+)-loaded liposomes are incubated with aromatic carboxylic acids and upon excitation at the absorption ..
  71. ncbi Low molecular weight carboxylic acids in oxidizing porphyry copper tailings
    Bernhard Dold
    Institute of Mineralogy and Geochemistry BFSH2, University of Lausanne, 1015 Lausanne, Switzerland
    Environ Sci Technol 39:2515-21. 2005
    The distribution of low molecular weight carboxylic acids (LMWCA) was investigated in pore water profiles from two porphyry copper tailings impoundments in Chile (Piuquenes at La Andina and Cauquenes at El Teniente mine)...
  72. ncbi Total synthesis of natural tert-alkylamino hydroxy carboxylic acids
    Sung Ho Kang
    Center for Molecular Design and Synthesis, Department of Chemistry, School of Molecular Science BK21, Korea Advanced Institute of Science and Technology KAIST, Daejeon
    Chem Rev 105:4537-58. 2005
  73. ncbi Friction force microscopy of alkylphosphonic acid and carboxylic acids adsorbed on the native oxide of aluminum
    Trevor T Foster
    Department of Chemistry, UMIST, P O Box 88, Manchester M60 1QD, UK
    Langmuir 22:9254-9. 2006
    ..These inferences were supported by PM-IRRAS data, which enabled the density of gauche defects to be estimated and correlated with variations in the coefficient of friction...
  74. ncbi Attraction of mosquitoes to volatiles associated with blood
    S A Allan
    Center for Medical, Agricultural and Veterinary Entomology, USDA ARS, 1600 1700 23rd Dr, Gainesville, FL 32608, USA
    J Vector Ecol 31:71-8. 2006
    ..These assay methods are effective for evaluation of volatile compounds from blood, and although responses were obtained to several compounds, none were as effective as blood in the olfactometer and landing assays...
  75. ncbi Anion-exchange chromatography-electrospray ionization mass spectrometry method development for the environmental analysis of aliphatic polyhydroxy carboxylic acids
    Axel Meyer
    Department of Analytical and Ecological Chemistry, Faculty VI Geography Geosciences, University of Trier, Campus II, Behringstrasse 21, D 54296 Trier, Germany
    J Chromatogr A 1170:62-72. 2007
    ..MS method was developed enabling the identification and quantification of 18 aliphatic (poly)hydroxy (poly)carboxylic acids including sugar and uronic acids...
  76. ncbi Production of perfluorinated carboxylic acids (PFCAs) from the biotransformation of polyfluoroalkyl phosphate surfactants (PAPS): exploring routes of human contamination
    Jessica C D'eon
    Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, Canada M5S 3H6
    Environ Sci Technol 41:4799-805. 2007
    ..Previous investigations have found that PAPS can migrate into food from paper packaging. Here we link ingestion of PAPS with in vivo production of perfluorinated acids...
  77. ncbi Dietary supplementation with beta-glucan enriched oat bran increases faecal concentration of carboxylic acids in healthy subjects
    U Nilsson
    Applied Nutrition and Food Chemistry, Department of Food Technology, Engineering and Nutrition, Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden
    Eur J Clin Nutr 62:978-84. 2008
    b>Carboxylic acids (CAs), especially butyric acid, have been suggested to counteract colonic diseases, such as ulcerative colitis and colon cancer...
  78. ncbi Human odor detection of homologous carboxylic acids and their binary mixtures
    Paul M Wise
    Monell Chemical Senses Center, Philadelphia, PA 19104 3308, USA
    Chem Senses 32:475-82. 2007
    ..concentration) functions were measured for aliphatic carboxylic acids and selected binary mixtures thereof...
  79. ncbi A novel-designed Escherichia coli for the production of various polyhydroxyalkanoates from inexpensive substrate mixture
    Rui Li
    State Key Laboratory of Microbial Technology, Life Science School, Shandong University, Jinan, 250100, People s Republic of China
    Appl Microbiol Biotechnol 75:1103-9. 2007
    ..Semiquantitative reverse transcription polymerase chain reaction analysis indicated that disrupting phosphoenolpyruvate: sugar PTS in this strain released the repression on fad genes...
  80. ncbi Aqueous in situ derivatization of carboxylic acids by an ionic carbodiimide and 2,2,2-trifluoroethylamine for electron-capture detection
    Quincy LaRon Ford
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
    J Chromatogr A 1145:241-5. 2007
    We report a technique for the rapid, room temperature derivatization of aqueous carboxylic acids to the corresponding 2,2,2-trifluoroethylamide derivative...
  81. ncbi Prediction of MS/MS data. 1. A focus on pharmaceuticals containing carboxylic acids
    Mary L Bandu
    Department of Chemistry, University of Kansas, Lawrence, Kansas 66045, USA
    Anal Chem 76:1746-53. 2004
    ..We are currently developing methods to define these fragmentation rules. By screening approximately 100 carboxylic acids at a time and applying knowledge of physical-organic chemistry, predictive rules are under development that ..
  82. ncbi Efficient production of (R)-3-hydroxycarboxylic acids by biotechnological conversion of polyhydroxyalkanoates and their purification
    Katinka Ruth
    Laboratories for Biomaterials, Swiss Federal Laboratories for Materials Testing and Research, Lerchenfeldstrasse 5, CH 9014 St Gallen, Switzerland
    Biomacromolecules 8:279-86. 2007
    ..All obtained monomers had a purity of over 95 wt %. The physical properties of the purified monomers and their antimicrobial activities were also investigated...
  83. ncbi A broad diversity of volatile carboxylic acids, released by a bacterial aminoacylase from axilla secretions, as candidate molecules for the determination of human-body odor type
    Andreas Natsch
    Givaudan Schweiz AG, Ueberlandstrasse 138, CH 8600 Duebendorf, Switzerland
    Chem Biodivers 3:1-20. 2006
    ..Over 28 different carboxylic acids were released by this enzyme from odorless axilla secretions (Table 1)...
  84. ncbi Functional analysis of Kluyveromyces lactis carboxylic acids permeases: heterologous expression of KlJEN1 and KlJEN2 genes
    Odília Queirós
    Instituto Superior de Ciências da Saúde Norte ISCSN, Rua Central da Gandra 1317 4585 116 Gandra, Paredes, Portugal
    Curr Genet 51:161-9. 2007
    ..work describes a detailed physiological and molecular characterization of the mechanisms of transport of carboxylic acids in Kluyveromyces lactis...
  85. ncbi Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors
    Li Fan Zeng
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China
    Bioorg Med Chem Lett 18:4521-4. 2008
    ..The synthesis of the heteroaromatic carboxylic acids was established by employing phenyl beta-diketoester or benzaldehyde as the starting material and 1,3-dipolar ..
  86. pmc Body odour of monozygotic human twins: a common pattern of odorant carboxylic acids released by a bacterial aminoacylase from axilla secretions contributing to an inherited body odour type
    Fabian Kuhn
    Analytical Chemistry, Givaudan Schweiz AG, Ueberlandstrasse 138, 8600 Duebendorf, Switzerland
    J R Soc Interface 6:377-92. 2009
    ..Volatile carboxylic acids are a key class of known human body odorants...
  87. doi Synergistic mixture interactions in detection of perithreshold odors by humans
    Toshio Miyazawa
    Flavor System and Technology Laboratory, R and D Control Division, Ogawa and Co Ltd, 15 7 Chidori Urayashu shi, Chiba 279 0032, Japan
    Chem Senses 33:363-9. 2008
    ..The current study examined perithreshold mixture interactions between maple lactone (ML) and selected carboxylic acids. An air-dilution olfactometer allowed precise stimulus control...
  88. ncbi Changes in organic acids and sugars during early stages of development of acidic and acidless citrus fruit
    Marie Vincente Albertini
    Institut National de la Recherche Agronomique INRA, UR GEQA, 20230 San Giuliano, France
    J Agric Food Chem 54:8335-9. 2006
    ..Our results provided the first complete report on sugar and organic acid accumulation during the early stages of fruit development in several citrus varieties...
  89. ncbi Transport of carboxylic acids in yeasts
    Margarida Casal
    Department of Biology, Molecular and Environmental Biology Centre CBMA, University of Minho, Braga, Portugal
    FEMS Microbiol Rev 32:974-94. 2008
    ..Here we review the current knowledge on yeast carboxylate transporters, at the biochemical and molecular level, focusing also on recent biotechnological developments...
  90. ncbi Odor detection of mixtures of homologous carboxylic acids and coffee aroma compounds by humans
    Toshio Miyazawa
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    J Agric Food Chem 57:9895-901. 2009
    Mixture summation among homologous carboxylic acids, that is, the relationship between detection probabilities for mixtures and detection probabilities for their unmixed components, varies with similarity in carbon-chain length...
  91. ncbi Stereospecific synthesis of (R)-2-hydroxy carboxylic acids using recombinant E. coli BL21 overexpressing YiaE from Escherichia coli K12 and glucose dehydrogenase from Bacillus subtilis
    Hyungdon Yun
    School of Chemical Engineering and Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Korea
    Biotechnol Prog 21:366-71. 2005
    ..The purified enzyme catalyzes reduction of various aromatic and aliphatic 2-oxo carboxylic acids to the corresponding (R)-2-hydoxy carboxylic acids using NADPH...
  92. ncbi Hydrophilic carboxylic acids and iridoid glycosides in the juice of American and European cranberries (Vaccinium macrocarpon and V. oxycoccos), lingonberries (V. vitis-idaea), and blueberries (V. myrtillus)
    Heidi D Jensen
    Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Copenhagen, Denmark
    J Agric Food Chem 50:6871-4. 2002
    ..A fast reversed-phase HPLC method for quantification of the hydrophilic carboxylic acids was developed and used for analyses of cranberry, lingonberry, and blueberry juices...
  93. ncbi Degradation of fluorotelomer alcohols: a likely atmospheric source of perfluorinated carboxylic acids
    David A Ellis
    Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, Canada M5S 3H6
    Environ Sci Technol 38:3316-21. 2004
    ..tissues collected in urban and remote global locations contain persistent and bioaccumulative perfluorinated carboxylic acids (PFCAs). The source of PFCAs was previously unknown...
  94. ncbi Carboxylic acids permeases in yeast: two genes in Kluyveromyces lactis
    Tiziana Lodi
    Dipartimento di Genetica Antropologia Evoluzione, University of Parma, Viale delle Scienze 11 A, 43100 Parma, Italy
    Gene 339:111-9. 2004
    ..malate and fumarate because the Kljen2 mutant cannot grow on these substrates and the succinate uptake is competed by these carboxylic acids. We conclude that KlJEN2 is the first yeast gene shown to encode a dicarboxylic acids permease.
  95. ncbi Olfactory sensitivity for carboxylic acids in spider monkeys and pigtail macaques
    Matthias Laska
    Department of Medical Psychology, University of Munich Medical School, Goethestr 31, D 80336 Munich, Germany
    Chem Senses 29:101-9. 2004
    ..the olfactory sensitivity of four spider monkeys and four pigtail macaques for a homologous series of carboxylic acids (n-propionic acid to n-heptanoic acid) was investigated...
  96. ncbi Oxidation of carboxylic acids by horseradish peroxidase results in prosthetic heme modification and inactivation
    Liusheng Huang
    Contribution from the Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, CA 94143 2280, USA
    J Am Chem Soc 126:12865-73. 2004
    ..functions known to be susceptible to oxidation by these catalysts, it is not known whether they can oxidize carboxylic acids to carboxylic radicals...
  97. pmc Effect of cilomilast (Ariflo) on TNF-alpha, IL-8, and GM-CSF release by airway cells of patients with COPD
    M Profita
    Istituto di Medicina Generale e Pneumologia, Universita di Palermo, Italy
    Thorax 58:573-9. 2003
    ....
  98. ncbi Adhesion to and decalcification of hydroxyapatite by carboxylic acids
    Y Yoshida
    Department of Biomaterials Science, Hiroshima University, Faculty of Dentistry, Japan
    J Dent Res 80:1565-9. 2001
    ..Based on these data, an adhesion/decalcification concept was advanced that predicts that carboxylic acids, regardless of concentration/pH, either adhere to or decalcify hydroxyapatite, depending on the dissolution ..
  99. ncbi Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease
    Elizabeth Gamble
    Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Respir Crit Care Med 168:976-82. 2003
    ..Phosphodiesterase-4 inhibitors represent a promising new class of substances for use in antiinflammatory treatment of this disease...
  100. ncbi Nasal pungency and odor of homologous aldehydes and carboxylic acids
    J E Cometto-Muniz
    Department of Surgery Otolaryngology, University of California, San Diego, La Jolla 92093 0957, USA
    Exp Brain Res 118:180-8. 1998
    ..measured odor and nasal pungency thresholds for homologous aliphatic aldehydes (butanal through octanal) and carboxylic acids (formic, acetic, butanoic, hexanoic, and octanoic)...
  101. ncbi Production of 3-hydroxy-n-phenylalkanoic acids by a genetically engineered strain of Pseudomonas putida
    Angel Sandoval
    Departamento de Bioquimica y Biologia Molecular, Facultad de Veterinaria, Universidad de Leon, 24007 Leon, Spain
    Appl Microbiol Biotechnol 67:97-105. 2005
    ..putida U (P. putida U DeltafadBA-phaZ) that efficiently bioconverts (more than 80%) different n-phenylalkanoic acids into their 3-hydroxyderivatives and excretes these compounds into the culture broth...

Research Grants66

  1. Synthetic Methods Involving Decarboxylative Coupling
    JON TUNGE; Fiscal Year: 2009
    ..The theme of this proposal is the replacement of these undesirable reagents with ubiquitous carboxylic acids. Decarboxylative metalation of carboxylic acid derivatives potentially allows formation of useful ..
  2. ION PAIR ALDOL ADDITION REACTIONS
    Andrew Streitwieser; Fiscal Year: 1999
    ..transfer equilibria and reaction kinetics of Aldol and Michael addition reactions to the dilithium salts of carboxylic acids and beta- diketones...
  3. EARLY TRANSITION METAL CATALYSTS FOR ORGANIC SYNTHESIS
    STEPHEN BUCHWALD; Fiscal Year: 1992
    ..to silyl ethers; 9) The conversion of oxindoles to indoles and butenolides to furans; 10) The conversion of carboxylic acids to alcohols and to aldehydes; and 11) The conversion of nitriles into aldehydes; The availability of ..
  4. INACTIVATION AND STRUCTURE AND GABA AMINOTRANSFERASE
    Richard Silverman; Fiscal Year: 1999
    ..corresponding acetylenic and fluoromethyl inactivator analogs, substituted phenols as lipophilic isosteres of carboxylic acids, 4-amino-2-difluoromethyl- 2-butenoic acid, 4-amino-2-trifluromethyl-2-butenoic acid, gamma-allenyl GABA, (E)-..
  5. THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENT
    George Sachs; Fiscal Year: 2007
    ..0 and K+ binding to luminal carbonyl groups displaces two of the carboxylic acids bound to lys 791, thereby allowing return ofIys791 and replacement by K+ at this site...
  6. THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENT
    George Sachs; Fiscal Year: 2005
    ..0 and K+ binding to luminal carbonyl groups displaces two of the carboxylic acids bound to lys 791, thereby allowing return ofIys791 and replacement by K+ at this site...
  7. THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENT
    George Sachs; Fiscal Year: 2006
    ..0 and K+ binding to luminal carbonyl groups displaces two of the carboxylic acids bound to lys 791, thereby allowing return ofIys791 and replacement by K+ at this site...
  8. THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENT
    George Sachs; Fiscal Year: 2009
    ..0 and K+ binding to luminal carbonyl groups displaces two of the carboxylic acids bound to lys 791, thereby allowing return ofIys791 and replacement by K+ at this site...
  9. ACYL GLUCURONIDES: COVALENT BINDING & PHARMACOKINETICS
    Leslie Benet; Fiscal Year: 1992
    ..It has recently become recognized that acyl glucuronides of carboxylic acids are unstable and reactive metabolites...
  10. ACYL GLUCURONIDES: COVALENT BINDING & PHARMACOKINETICS
    Leslie Benet; Fiscal Year: 1993
    ..It has recently become recognized that acyl glucuronides of carboxylic acids are unstable and reactive metabolites...
  11. ACYL GLUCURONIDES: COVALENT BINDING & PHARMACOKINETICS
    Leslie Benet; Fiscal Year: 1991
    ..It has recently become recognized that acyl glucuronides of carboxylic acids are unstable and reactive metabolites...
  12. NOVEL SYNTHESIS & APPLICATIONS OF DIAZOMETHANE
    MANOUCHEHR SALJOUGHIAN; Fiscal Year: 1999
    ..It is easily the most common methylating reagent for carboxylic acids, and has found wide application in the methylation of phenols, alcohols, enols, and heteroatoms such as ..
  13. Novel agents against West Nile Virus infections
    Krzysztof Pankiewicz; Fiscal Year: 2003
    ..simple, unexplored yet analogues of MPA that are expected to show different physicochemical properties than carboxylic acids (such as MPA) and may show favorable pharmacokinetic...
  14. MOLECULAR MECHANISM OF RETINOID ACTION
    Xiao Kun Zhang; Fiscal Year: 1999
    Retinoid carboxylic acids, the natural derivatives and synthetic analogs of vitamin A, are fundamental mediators of many biological processes, including differentiation, proliferation, and morphogenesis...
  15. MOLECULAR MECHANISM OF RETINOID ACTION
    Xiao Kun Zhang; Fiscal Year: 1999
    Retinoid carboxylic acids, the natural derivatives and synthetic analogs of vitamin A, are fundamental mediators of many biological processes, including differentiation, proliferation, and morphogenesis...
  16. MOLECULAR MECHANISM OF RETINOID ACTION
    Xiao Kun Zhang; Fiscal Year: 2002
    Retinoid carboxylic acids, the natural derivatives and synthetic analogs of vitamin A, are fundamental mediators of many biological processes, including differentiation, proliferation, and morphogenesis...
  17. BIOTRANSFORMATION OF CANNABINOIDS BY MICROORGANISMS
    Larry Robertson; Fiscal Year: 1980
    ..Particular emphasis will be placed on the mono- and dihydroxylated metabolites, carboxylic acids and hydroxy acids which are difficult to produce by conventional organic synthetic methods...
  18. MOLECULAR MECHANISM OF RETINOID ACTION
    Xiao Kun Zhang; Fiscal Year: 2000
    Retinoid carboxylic acids, the natural derivatives and synthetic analogs of vitamin A, are fundamental mediators of many biological processes, including differentiation, proliferation, and morphogenesis...
  19. Arthropod-Based Libraries for High Throughput Screening
    Frank Schroeder; Fiscal Year: 2007
    ..While many of the compounds we have characterized have simple structures (such as straight chain alkenes, carboxylic acids, aldehydes, phenols, benzoquinones), there are also many examples of biologically active alkaloids, ..
  20. Arthropod-Based Libraries for High Throughput Screening
    Jerrold Meinwald; Fiscal Year: 2007
    ..While many of the compounds we have characterized have simple structures (such as straight chain alkenes, carboxylic acids, aldehydes, phenols, benzoquinones), there are also many examples of biologically active alkaloids, ..
  21. NITROGEN CONTAINING NATURAL PRODUCTS
    Stephen Martin; Fiscal Year: 2002
    ..synthesis of fused nitrogen heterocycles; (2) Develop a synthetic method for the homologation of carboxylic acids into alpha, beta-unsaturated ketones; and (3) Develop an efficient, stereoselective procedure for the ..
  22. NITROGEN CONTAINING NATURAL PRODUCTS
    Stephen Martin; Fiscal Year: 2005
    ..synthesis of fused nitrogen heterocycles; (2) Develop a synthetic method for the homologation of carboxylic acids into alpha, beta-unsaturated ketones; and (3) Develop an efficient, stereoselective procedure for the ..
  23. Optimization of pyrimidinyl prodrugs (PYPs) for malaria chemotherapy
    PRADIPSINH RATHOD; Fiscal Year: 2009
    ..chemistry, trioxanes and tetraoxane derivatives of PYP1 will be made to selectively release the active carboxylic acids in the parasite (iii) Cell-based screens and toxicity panels will be implemented and used to identify ..
  24. Arthropod-Based Libraries for High Throughput Screening
    Frank Schroeder; Fiscal Year: 2009
    ..While many of the compounds we have characterized have simple structures (such as straight chain alkenes, carboxylic acids, aldehydes, phenols, benzoquinones), there are also many examples of biologically active alkaloids, ..
  25. NITROGEN CONTAINING NATURAL PRODUCTS
    Stephen Martin; Fiscal Year: 2004
    ..synthesis of fused nitrogen heterocycles; (2) Develop a synthetic method for the homologation of carboxylic acids into alpha, beta-unsaturated ketones; and (3) Develop an efficient, stereoselective procedure for the ..
  26. NITROGEN CONTAINING NATURAL PRODUCTS
    Stephen Martin; Fiscal Year: 2003
    ..synthesis of fused nitrogen heterocycles; (2) Develop a synthetic method for the homologation of carboxylic acids into alpha, beta-unsaturated ketones; and (3) Develop an efficient, stereoselective procedure for the ..
  27. STRUCTURE DETERMINATION BY TRIPLE QUAD MASS SPECTROMETRY
    CHRISTIE ENKE; Fiscal Year: 1980
    ..Alcohols, ethers, aldehydes, ketones, esters, and carboxylic acids, amides, amines, nitriles, and nitro compounds with linear, branched, cyclic, and aromatic skeletons will be ..
  28. Peptidomimetics of D-Ala-D-Ala as Novel Antibacterials
    Norma Dunlap; Fiscal Year: 2003
    ..Tetrazoles have been used successfully as bioisosteric replacements for the carboxylic acids in a number of drugs. An example is the angiotensin receptor antagonist Losartan...
  29. Synthetic Methods Involving Decarboxylative Coupling
    JON TUNGE; Fiscal Year: 2007
    ..The theme of this proposal is the replacement of these undesirable reagents with ubiquitous carboxylic acids. Decarboxylative metalation of carboxylic acid derivatives potentially allows formation of useful ..
  30. BIOLOGICALLY ACTIVE STEROID ANALOGS
    RICHARD HOCHBERG; Fiscal Year: 1999
    ..We have synthesized several analogs of estradiol that have been modified with carboxylic acids, and have little or no affinity for the estrogen receptor and are therefore not estrogenic...
  31. SYNTHESIS OF NEW TITANIUM, PLATINUM, AND RUTHENIUM ANTICANCER DRUGS
    SANTOSIN MANDAL; Fiscal Year: 2000
    ..be obtained from the reactions of the corresponding alditolate or carbonate complexes with the corresponding carboxylic acids. The carboxylate complexes of platinum containing organotin fragment may be synthesized from the reactions of ..
  32. SYNTHESIS OF NEW TITANIUM, PLATINUM, AND RUTHENIUM ANTICANCER DRUGS
    SANTOSIN MANDAL; Fiscal Year: 1999
    ..be obtained from the reactions of the corresponding alditolate or carbonate complexes with the corresponding carboxylic acids. The carboxylate complexes of platinum containing organotin fragment may be synthesized from the reactions of ..
  33. Synthetic Methods Involving Decarboxylative Coupling
    Jon A Tunge; Fiscal Year: 2010
    ..The theme of this proposal is the replacement of these undesirable reagents with ubiquitous carboxylic acids. Decarboxylative metalation of carboxylic acid derivatives potentially allows formation of useful ..
  34. BIOLOGICALLY ACTIVE STEROID ANALOGS
    RICHARD HOCHBERG; Fiscal Year: 2000
    ..We have synthesized several analogs of estradiol that have been modified with carboxylic acids, and have little or no affinity for the estrogen receptor and are therefore not estrogenic...
  35. MACROMOLECULAR PATTERN RECOGNITION & ONLINE ACCESS TO MOLEC BIOL TOOLS: DNA SEQ
    Michael Gribskov; Fiscal Year: 1999
    ..solvent on structures and relative energies of various conformers such as betaines and sulfobetaines, ethers, carboxylic acids, aldehydes and ketones was studied using the DMol/COSMO model...
  36. CNS DELIVERY OF ALKANOATE ANTIEPILEPTICS
    Danny Shen; Fiscal Year: 1999
    ..and blood-cerebrospinal fluid (CSF) barriers is mediated by membrane transport carriers for endogenous carboxylic acids, (2) individual differences in the physiologic regulation of these transport processes accounts for the ..
  37. CNS DELIVERY OF ALKANOATE ANTIEPILEPTICS
    Danny Shen; Fiscal Year: 1999
    ..and blood-cerebrospinal fluid (CSF) barriers is mediated by membrane transport carriers for endogenous carboxylic acids, (2) individual differences in the physiologic regulation of these transport processes accounts for the ..
  38. Incorporating Thyronamines into Thyroid Hormone Metabolism
    WARREN WOOD; Fiscal Year: 2006
    ..Again the enzymes for the proposed transformations are present in the liver. An extraction for carboxylic acids followed by chromatographic separation of the products and comparison to triiodothyroacetic acid and other ..
  39. MACROMOLECULAR PATTERN RECOGNITION & ONLINE ACCESS TO MOLEC BIOL TOOLS: DNA SEQ
    Michael Gribskov; Fiscal Year: 2001
    ..solvent on structures and relative energies of various conformers such as betaines and sulfobetaines, ethers, carboxylic acids, aldehydes and ketones was studied using the DMol/COSMO model...
  40. CNS DELIVERY OF ALKANOATE ANTIEPILEPTICS
    Danny Shen; Fiscal Year: 1992
    ..and blood-cerebrospinal fluid (CSF) barriers is mediated by membrane transport carriers for endogenous carboxylic acids, (2) individual differences in the physiologic regulation of these transport processes accounts for the ..
  41. Supercritical carbon dioxide for drying and sterilizing parenteral dosage forms
    Charles Decedue; Fiscal Year: 2009
    ..g., alcohols, amines, thiols, carboxylic acids, etc.) that may prove susceptible to damage...
  42. MACROMOLECULAR PATTERN RECOGNITION & ONLINE ACCESS TO MOLEC BIOL TOOLS: DNA SEQ
    Michael Gribskov; Fiscal Year: 2000
    ..solvent on structures and relative energies of various conformers such as betaines and sulfobetaines, ethers, carboxylic acids, aldehydes and ketones was studied using the DMol/COSMO model...
  43. PILOT--Molecular Recognition of Biomolecules by Metal Complexes: Host-Guest Chem
    JUDITH WALMSLEY; Fiscal Year: 2003
    ..Molecules to be tested include amino acids, carboxylic acids, and aromatic and aliphatic compounds...
  44. CHEMICAL SENSORY IRRITATION--CONTRAST WITH OLFACTION
    J Cometto Muniz; Fiscal Year: 1999
    ..Stimuli will comprise homologous series of compounds (e.g., aldehydes, carboxylic acids, terpenes). Physicochemical properties change systematically in such series...
  45. SODIUM CHANNEL GATING IN MODELS OF MYOTONIA
    Robert Ruff; Fiscal Year: 1990
    ..will be produced by: 1) bathing a fiber in a chloride- deficient solution, 2) treating fibers with aromatic carboxylic acids to reduce chloride conductance, and 3) treating rats with 20, 25-diazacholesterol...
  46. PYRUVATE ALDOLASES IN ORGANIC SYNTHESIS
    Eric Toone; Fiscal Year: 1993
    ..the stereospecific condensation of pyruvate with an electrophile aldehyde to generate 2-keto-4-hydroxy carboxylic acids. This conserved four-carbon segment is ideally suited for further synthetic elaboration in the preparation of ..
  47. METABOLIC EFFECTS OF THYROID HORMONES IN CELL CULTURE
    Herbert Samuels; Fiscal Year: 1980
    ..In addition, sodium n-butyrate and other aliphatic carboxylic acids elicit a reduction in thyroid hormone nuclear receptor levels without altering total cell protein synthetic ..
  48. ACYLCOA FORMATION--COVALENT BINDING, PHARMACOKINETICS
    Leslie Benet; Fiscal Year: 2002
    ..inhibitors, with respect to acyl glucuronidation and acyl-CoA formation, on the covalent binding of selected carboxylic acids to protein; 3) To quantitatively determine and compare the levels of drug-protein acylation, acyl ..
  49. ACYLCOA FORMATION--COVALENT BINDING, PHARMACOKINETICS
    Leslie Benet; Fiscal Year: 1999
    ..inhibitors, with respect to acyl glucuronidation and acyl-CoA formation, on the covalent binding of selected carboxylic acids to protein; 3) To quantitatively determine and compare the levels of drug-protein acylation, acyl ..
  50. ACYLCOA FORMATION--COVALENT BINDING, PHARMACOKINETICS
    Leslie Benet; Fiscal Year: 2001
    ..inhibitors, with respect to acyl glucuronidation and acyl-CoA formation, on the covalent binding of selected carboxylic acids to protein; 3) To quantitatively determine and compare the levels of drug-protein acylation, acyl ..
  51. ACYLCOA FORMATION--COVALENT BINDING, PHARMACOKINETICS
    Leslie Benet; Fiscal Year: 2000
    ..inhibitors, with respect to acyl glucuronidation and acyl-CoA formation, on the covalent binding of selected carboxylic acids to protein; 3) To quantitatively determine and compare the levels of drug-protein acylation, acyl ..
  52. MOLECULAR TOXICOLOGY OF DNA ADDUCTS
    ARTHUR GROLLMAN; Fiscal Year: 2009
    ..with the chemical biology of the aristolochic acids (AAs), a series of naturally-occurring nitrophenanthrene carboxylic acids, and their related lactams. The toxic effects of AAs lead to chronic renal disease and urothelial cancer...
  53. Azides as Synthons for Isonitriles: Facilitating Challenging Coupling Reactions
    JENNIFER LYNN STOCKDILL; Fiscal Year: 2010
    ..improvements to the efficacy of the previously described two-component coupling of isonitriles with carboxylic acids to access primary and secondary amide derivatives...
  54. Dynamic Metabolomics via Isotopomer Analysis(RMI)
    Henri Brunengraber; Fiscal Year: 2005
    ..for the concentration and mass isotopomer distribution of metabolites (acyl-CoAs, acylcarnitines, aminoacids, carboxylic acids, as well as intermediates of glycolysis, the pentosephosphate pathway, and the citric acid cycle) extracted ..
  55. Dynamic Metabolomics via Isotopomer Analysis
    Henri Brunengraber; Fiscal Year: 2006
    ..for the concentration and mass isotopomer distribution of metabolites (acyl-CoAs, acylcarnitines, aminoacids, carboxylic acids, as well as intermediates of glycolysis, the pentosephosphate pathway, and the citric acid cycle) extracted ..
  56. UDP-Glucuronic Acid Regeneration System
    INMAR MUNIR; Fiscal Year: 2004
    ..toward compounds with a wide variety of chemical structures, such as amines, hydroxylated compounds, and carboxylic acids. Therefore, phase II metabolism (conjugation) is often independent of phase I (functionalization) metabolic ..
  57. Dynamic Metabolomics via Isotopomer Analysis (RMI)
    Henri Brunengraber; Fiscal Year: 2004
    ..for the concentration and mass isotopomer distribution of metabolites (acyl-CoAs, acylcarnitines, aminoacids, carboxylic acids, as well as intermediates of glycolysis, the pentosephosphate pathway, and the citric acid cycle) extracted ..
  58. Dynamic Metabolomics via Isotopomer Analysis(RMI)
    Henri Brunengraber; Fiscal Year: 2005
    ..for the concentration and mass isotopomer distribution of metabolites (acyl-CoAs, acylcarnitines, aminoacids, carboxylic acids, as well as intermediates of glycolysis, the pentosephosphate pathway, and the citric acid cycle) extracted ..
  59. The Molecular Recognition of Wine and Urine
    Eric Anslyn; Fiscal Year: 2005
    ..We propose to target five classes of analytes: carboxylic acids, sugars, pectins, tannins, and gluoconorides. These classes present different challenges for fingerprinting...
  60. Refining & Implementing Supramolecular Methods for HTS of EE & Concentration
    Eric V Anslyn; Fiscal Year: 2010
    ..will be to complete a few assays for chiral functional groups that are almost operational (primary amines, carboxylic acids, and ketones), and we will devise an assay for chiral secondary alcohols...
  61. PYRUVATE ETHYL ESTER AS TREATMENT FOR REPERFUSION INJURY
    Alfred Ajami; Fiscal Year: 2000
    ..Esterified carboxylic acids, structurally related to pyruvate, can form stable solutions in the presence of calcium (or magnesium) ions ..