azo compounds

Summary

Top Publications

  1. ncbi Degradation of azo dye Procion Red MX-5B by photocatalytic oxidation
    C M So
    Department of Biology, The Chinese University of Hong Kong, Shatin, NT
    Chemosphere 46:905-12. 2002
  2. ncbi Photocatalytic decolorization of azo-dye with zinc oxide powder in an external UV light irradiation slurry photoreactor
    Junpei Nishio
    Research Center for Biochemical and Environmental Engineering, Department of Applied Chemistry, Toyo University, Kawagoe, Saitama 350 8585, Japan
    J Hazard Mater 138:106-15. 2006
  3. doi Synthesis and characterization of azo compounds and study of the effect of substituents on their liquid crystalline behavior
    Uhood J Al-Hamdani
    Department of Chemistry, College of Education, Basrah University, Basrah, Iraq
    Molecules 15:5620-8. 2010
  4. pmc CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor
    Bin Zhao
    Department of Environmental Toxicology, University of California, Davis, California 95616 8588, USA
    Toxicol Sci 117:393-403. 2010
  5. doi Multiplex coherent anti-stokes Raman spectroscopy images intact atheromatous lesions and concomitantly identifies distinct chemical profiles of atherosclerotic lipids
    Se Hwa Kim
    Center for Nano Bio Technology, Korea Research Institute of Standards and Science, 1 Doryong dong, Yuseong Gu, Daejeon 305 340, Republic of Korea
    Circ Res 106:1332-41. 2010
  6. doi A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells
    A B Fielding
    Department of Integrative Oncology, British Columbia Cancer Research Centre of the BC Cancer Agency, Vancouver, British Columbia, Canada
    Oncogene 30:521-34. 2011
  7. pmc Imaging immune and metabolic cells of visceral adipose tissues with multimodal nonlinear optical microscopy
    Yasuyo Urasaki
    Human Health and Environment Program, Desert Research Institute, Las Vegas, Nevada, United States of America
    PLoS ONE 7:e38418. 2012
  8. pmc JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells
    Tanyel Kiziltepe
    Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Blood 110:709-18. 2007
  9. ncbi JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity
    Paul J Shami
    Division of Medical Oncology, Department of Internal Medicine, University of Utah and Salt Lake City Veterans Administration Medical Centers, Salt Lake City, Utah 84148, USA
    Mol Cancer Ther 2:409-17. 2003
  10. ncbi Contrast viscosity changes upon photoirradiation for mixtures of poly(acrylic acid)-based alpha-cyclodextrin and azobenzene polymers
    Itsuro Tomatsu
    Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka 560 0043, Japan
    J Am Chem Soc 128:2226-7. 2006

Detail Information

Publications254 found, 100 shown here

  1. ncbi Degradation of azo dye Procion Red MX-5B by photocatalytic oxidation
    C M So
    Department of Biology, The Chinese University of Hong Kong, Shatin, NT
    Chemosphere 46:905-12. 2002
    ..Nevertheless, the persistence of a low level of TOC indicated that mineralization was not complete and dead-end product(s) which was (were) resistant to PCO might have accumulated...
  2. ncbi Photocatalytic decolorization of azo-dye with zinc oxide powder in an external UV light irradiation slurry photoreactor
    Junpei Nishio
    Research Center for Biochemical and Environmental Engineering, Department of Applied Chemistry, Toyo University, Kawagoe, Saitama 350 8585, Japan
    J Hazard Mater 138:106-15. 2006
    ....
  3. doi Synthesis and characterization of azo compounds and study of the effect of substituents on their liquid crystalline behavior
    Uhood J Al-Hamdani
    Department of Chemistry, College of Education, Basrah University, Basrah, Iraq
    Molecules 15:5620-8. 2010
    In this paper we present six select mesomorphic azo compounds distinguished by the presence of diverse substituents on a central benzene nucleus. All the synthesized compounds exhibit enantiotropic mesophases...
  4. pmc CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor
    Bin Zhao
    Department of Environmental Toxicology, University of California, Davis, California 95616 8588, USA
    Toxicol Sci 117:393-403. 2010
    ....
  5. doi Multiplex coherent anti-stokes Raman spectroscopy images intact atheromatous lesions and concomitantly identifies distinct chemical profiles of atherosclerotic lipids
    Se Hwa Kim
    Center for Nano Bio Technology, Korea Research Institute of Standards and Science, 1 Doryong dong, Yuseong Gu, Daejeon 305 340, Republic of Korea
    Circ Res 106:1332-41. 2010
    ..However, their physiological role on the progression of atherosclerosis including plaque vulnerability has not been clearly understood, because of the lack of appropriate tools for chemical assessment...
  6. doi A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells
    A B Fielding
    Department of Integrative Oncology, British Columbia Cancer Research Centre of the BC Cancer Agency, Vancouver, British Columbia, Canada
    Oncogene 30:521-34. 2011
    ..In addition, we identify a specific TACC3 phosphorylation site that is required for centrosome clustering and demonstrate that ILK regulates this phosphorylation in an Aurora-A-dependent manner...
  7. pmc Imaging immune and metabolic cells of visceral adipose tissues with multimodal nonlinear optical microscopy
    Yasuyo Urasaki
    Human Health and Environment Program, Desert Research Institute, Las Vegas, Nevada, United States of America
    PLoS ONE 7:e38418. 2012
    ..With its versatility, NLO microscopy should be a powerful imaging tool to complement molecular characterization of the immunity-metabolism interface...
  8. pmc JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells
    Tanyel Kiziltepe
    Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Blood 110:709-18. 2007
    ..Taken together, these data provide the preclinical rationale for the clinical evaluation of JS-K to improve patient outcome in MM...
  9. ncbi JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity
    Paul J Shami
    Division of Medical Oncology, Department of Internal Medicine, University of Utah and Salt Lake City Veterans Administration Medical Centers, Salt Lake City, Utah 84148, USA
    Mol Cancer Ther 2:409-17. 2003
    ..Similar results were seen with s.c. human prostate cancer (PPC-1) xenografts. Our data indicate that JS-K is a promising lead compound for the possible development of a novel class of antineoplastic agents...
  10. ncbi Contrast viscosity changes upon photoirradiation for mixtures of poly(acrylic acid)-based alpha-cyclodextrin and azobenzene polymers
    Itsuro Tomatsu
    Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka 560 0043, Japan
    J Am Chem Soc 128:2226-7. 2006
    ....
  11. ncbi A glutathione S-transferase pi-activated prodrug causes kinase activation concurrent with S-glutathionylation of proteins
    Danyelle M Townsend
    Department of Pharmaceutical Science, Medical University of South Carolina, Charleston, 29425, USA
    Mol Pharmacol 69:501-8. 2006
    ..These effects were consistent with the presence of intracellular PABA/NO or metabolites, because cells overexpressing MRP1 were less sensitive to the drug and had reduced levels of S-glutathionylated proteins...
  12. ncbi Biodegradation of benzidine based dye Direct Blue-6 by Pseudomonas desmolyticum NCIM 2112
    S D Kalme
    Department of Biochemistry, Shivaji University, Kolhapur 416 004, India
    Bioresour Technol 98:1405-10. 2007
    ..The biodegradation was monitored by UV-Vis, IR spectroscopy and HPLC. The final products, 4-amino naphthalene and amino naphthalene sulfonic acid were characterized by GC-mass spectroscopy...
  13. ncbi Azobenzene-modified poly(l-glutamic acid) (AZOPLGA): its conformational and photodynamic properties
    Suizhou Yang
    Center for Advanced Materials, Department of Chemistry, University of Massachusetts Lowell, 01854, USA
    Biomacromolecules 4:366-71. 2003
    ..However, the modulations of the surface relief gratings, the result of photoinduced mass transport process, recorded on these polymers are sensitive to polymer main chain conformation, as well as the degree of functionalization...
  14. ncbi Fast liquid-crystal elastomer swims into the dark
    Miguel Camacho-Lopez
    Liquid Crystal Institute, Kent State University, Kent, Ohio 44242, USA
    Nat Mater 3:307-10. 2004
    ..We analyse the propulsion mechanism in terms of momentum transfer...
  15. ncbi Photoresponsive dendritic azobenzene peptides
    A Cattani-Scholz
    , Am Klopferspitz 18a, 82152 Martinsried, Germany
    Chembiochem 2:542-9. 2001
    ....
  16. pmc Photoswitchable gel assembly based on molecular recognition
    Hiroyasu Yamaguchi
    Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka 560 0043, Japan
    Nat Commun 3:603. 2012
    ..The differential affinities of α-cyclodextrin or β-cyclodextrin for the trans-azobenzene and cis-azobenzene are employed in the construction of a photoswitchable gel assembly system...
  17. ncbi Decolourization of azo dyes using magnesium-palladium system
    Rachna Patel
    Centre for Environmental Science and Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, Maharashtra, India
    J Hazard Mater 137:1729-41. 2006
    ..Mg(0)/Pd(4+) system was found to be efficient in decolourizing mixture of drimarene, remazol and procion dyes as well as raw effluent generated by textile dye manufacturing company...
  18. doi Pleurotus ostreatus manganese-dependent peroxidase silencing impairs decolourization of Orange II
    Tomer M Salame
    Department of Plant Pathology and Microbiology, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Microb Biotechnol 3:93-106. 2010
    ..ostreatus, which may have significant implication on understanding the mechanisms governing lignin biodegradation. Moreover, this study has proven the applicability of RNAi as a tool for gene function studies in Pleurotus research...
  19. ncbi PABA/NO as an anticancer lead: analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity
    Joseph E Saavedra
    Basic Research Program, SAIC Frederick, Chemistry Section, Laboratory of Comparative Carcinogenesis, and Biomolecular Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Med Chem 49:1157-64. 2006
    ..Consistent with PABA/NO's potent suppression of A2780 human ovarian cancer xenograft growth in mice, it was the most potent of the four in the OVCAR-3 cell line...
  20. pmc Validating the use of a luciferase labeled breast cancer cell line, MDA435LCC6, as a means to monitor tumor progression and to assess the therapeutic activity of an established anticancer drug, docetaxel (Dt) alone or in combination with the ILK inhibitor
    Jessica Kalra
    British Columbia Cancer Agency, Vancouver, BC, Canada
    Cancer Biol Ther 11:826-38. 2011
    ..These studies highlight a need for more comprehensive in vivo efficacy studies designed to assess multiple disease models and multiple endpoints, focusing analysis of drug parameters on the most chemoresistant disease...
  21. ncbi Azobenzene-based light-responsive hydrogel system
    Yan Li Zhao
    Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, California 90095, USA
    Langmuir 25:8442-6. 2009
    ..The swelling ratio for fresh hydrogel samples, which was found to be 8.7 +/- 0.7, was measured for a number of gel-to-sol and sol-to-gel phase-transition cycles...
  22. doi JS-K, a nitric oxide-releasing prodrug, modulates ß-catenin/TCF signaling in leukemic Jurkat cells: evidence of an S-nitrosylated mechanism
    Niharika Nath
    Department of Physiology and Pharmacology, City University of New York Medical School, 138th Street and Convent Avenue, New York, NY 10031, United States
    Biochem Pharmacol 80:1641-9. 2010
    ..The NO scavenger PTIO abrogated the JS-K mediated degradation of β-catenin demonstrating the need for NO...
  23. pmc JS-K has potent anti-angiogenic activity in vitro and inhibits tumour angiogenesis in a multiple myeloma model in vivo
    Tanyel Kiziltepe
    Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    J Pharm Pharmacol 62:145-51. 2010
    ..We have designed a prodrug class that releases nitric oxide on metabolism by GST. O(2)-(2,4-Dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K, a member of this class) has potent antineoplastic activity...
  24. pmc Physiology and biochemistry of reduction of azo compounds by Shewanella strains relevant to electron transport chain
    Yi guo Hong
    Key Laboratory of Tropical Marine Environment Dynamics LED, South China Sea Institute of Oceanography, Chinese Academy of Sciences, 164 Xingang Road West, Guangzhou 510301, People s Republic of China
    Appl Microbiol Biotechnol 88:637-43. 2010
    ..These new discoveries on the respiration pathways and electron transfer for bacterial azo reduction has potential biotechnological implications in cleaning up contaminated sites...
  25. ncbi Host-guest complexation affected by pH and length of spacer for hydroxyazobenzene-modified cyclodextrins
    Tetsuo Kuwabara
    Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 4 3 11 Takeda, Kofu 400 8511 Japan
    J Phys Chem A 110:13521-9. 2006
    ....
  26. ncbi Potassium diazoacetate-induced p53 mutations in vitro in relation to formation of O6-carboxymethyl- and O6-methyl-2'-deoxyguanosine DNA adducts: relevance for gastrointestinal cancer
    Elke Gottschalg
    MRC Toxicology Unit, Hodgkin Building, University of Leicester P O Box 138, Lancaster Road, Leicester LE1 9HN, and Leeds Institute of Molecular Medicine, St Jame s University Hospital, UK
    Carcinogenesis 28:356-62. 2007
    ....
  27. ncbi An improved and cost-effective methodology for the reduction of autofluorescence in direct immunofluorescence studies on formalin-fixed paraffin-embedded tissues
    M S Viegas
    Molecular Pathology Laboratory, Portuguese Institute for Oncology of Coimbra IPOCFG EPE, Coimbra, Portugal
    Eur J Histochem 51:59-66. 2007
    ..In addition, we herein show that this methodology is highly effective in reducing autofluorescent background to levels that allow detection of specific signals by direct immunofluorescence...
  28. ncbi Controlled photochemical release of nitric oxide from O2-substituted diazeniumdiolates
    Christopher M Pavlos
    Department of Chemistry, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
    Free Radic Biol Med 37:745-52. 2004
    ..In addition, the photochemistry of diazeniumdiolate salts themselves is covered...
  29. ncbi Single-molecule optomechanical cycle
    Thorsten Hugel
    Lehrstuhl fur Angewandte Physik and Center for Nanoscience, Ludwig Maximilians Universitat, Amalienstrasse 54, 80799 Munchen, Germany
    Science 296:1103-6. 2002
    ..As a proof of principle, the polymer was operated in a periodic mode, demonstrating for the first time optomechanical energy conversion in a single-molecule device...
  30. ncbi Preparation and reactivity of O2-sulfonated diazeniumdiolates
    Raechelle A D'Sa
    Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA
    J Org Chem 68:656-7. 2003
    ..This new class of compounds extends the range of O2-substituted diazeniumdiolates available for potential applications in research and medicine...
  31. pmc An adipogenic cofactor bound by the differentiation domain of PPARgamma
    G Castillo
    Dana Farber Cancer Institute, 44 Binney Street Boston, MA 02115, USA
    EMBO J 18:3676-87. 1999
    ..These results suggest that interactions between PGC-2, a receptor isoform-selective cofactor and PPARgamma contribute to the adipogenic action of this receptor...
  32. doi JS-K, a nitric oxide-releasing prodrug, induces breast cancer cell death while sparing normal mammary epithelial cells
    Vanity McMurtry
    Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Int J Oncol 38:963-71. 2011
    ..The selective anti-tumor activity of JS-K warrants its further investigation in breast tumors...
  33. pmc Hydrolytic reactivity trends among potential prodrugs of the O2-glycosylated diazeniumdiolate family. Targeting nitric oxide to macrophages for antileishmanial activity
    Carlos A Valdez
    Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Med Chem 51:3961-70. 2008
    ....
  34. pmc Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class
    Daniela Andrei
    Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, United States
    J Am Chem Soc 132:16526-32. 2010
    ....
  35. pmc "Click" reaction in conjunction with diazeniumdiolate chemistry: developing high-load nitric oxide donors
    Oyebola A Oladeinde
    Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Org Lett 12:4256-9. 2010
    ..Neither set of "click" conditions showed evidence of compromising the integrity of the diazeniumdiolate groups. The chemistry developed has applications in the synthesis of polyvalent and dendritic nitric oxide donors...
  36. ncbi Nitric oxide releasing silicone rubbers with improved blood compatibility: preparation, characterization, and in vivo evaluation
    Huiping Zhang
    Department of Chemistry, University of Michigan, Ann Arbor 48109 1055, USA
    Biomaterials 23:1485-94. 2002
    ....
  37. ncbi Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies
    Carlos Velazquez
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada
    J Med Chem 48:4061-7. 2005
    ..Accordingly, these hybrid (*)NO-NSAID prodrugs possessing a diazen-1-ium-1,2-diolate moiety, represent a new approach for the rational design of antiinflammatory drugs with reduced gastric ulcerogenicity...
  38. ncbi Antitumor activity of JS-K [O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and related O2-aryl diazeniumdiolates in vitro and in vivo
    Paul J Shami
    Department of Internal Medicine, Division of Medical Oncology, University of Utah, Salt Lake City, 84112, USA
    J Med Chem 49:4356-66. 2006
    ..In addition to the above-mentioned in vivo activities, JS-K is shown here to be carcinostatic in a rat liver cancer model...
  39. ncbi Nitric oxide-releasing fabrics and other acrylonitrile-based diazeniumdiolates
    Frank Derosa
    Chemistry Section, Laboratory of Comparative Carcinogenesis and Basic Research Program, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Am Chem Soc 129:3786-7. 2007
  40. ncbi Eriochrome Black T inhibits endothelial cell growth through S-phase blockade
    I Langer
    Department of Biochemistry and Nutrition, Faculty of Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Eur J Pharmacol 399:85-90. 2000
    ..These results suggest that in addition of its more potent antiproliferative effect on endothelial cell growth, Eriochrome Black T acts at another molecular level than suramin...
  41. pmc HNO and NO release from a primary amine-based diazeniumdiolate as a function of pH
    Debra J Salmon
    Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, USA
    Inorg Chem 50:3262-70. 2011
    ..This pH-dependent variability in product formation may prove useful in examination of the chemistry of NO and HNO. Furthermore, primary amine NONOates may serve as a tunable class of nitrogen oxide donor...
  42. pmc The nitric oxide prodrug JS-K is effective against non-small-cell lung cancer cells in vitro and in vivo: involvement of reactive oxygen species
    Anna E Maciag
    SAIC Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    J Pharmacol Exp Ther 336:313-20. 2011
    ..PRX1 and OGG1 proteins, which can be easily measured, could function as biomarkers for identifying tumors sensitive to the therapy...
  43. ncbi Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis
    K J Duffy
    GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA
    J Med Chem 44:3730-45. 2001
    ..Potencies for the best compounds were high for such low molecular weight compounds (MW < 500) with EC(50) values in the region of 1-20 nM...
  44. ncbi Influence of synthetic and natural food dyes on activities of CYP2A6, UGT1A6, and UGT2B7
    Nayumi Kuno
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    J Toxicol Environ Health A 68:1431-44. 2005
    ..In the natural additive dyes just listed, only monascus inhibited UGT1A6 and UGT2B7...
  45. ncbi DNA damage induced by red food dyes orally administered to pregnant and male mice
    S Tsuda
    Laboratory of Veterinary Public Health, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Ueda 3 18 8, Morioka, Iwate 020 8550, Japan
    Toxicol Sci 61:92-9. 2001
    ..N-nitrosodiethylamine at 14 mg/kg did not induce DNA damage in any organs examined. Because the 3 azo additives we examined induced colon DNA damage at a very low dose, more extensive assessment of azo additives is warranted...
  46. ncbi Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo
    Katrina M Miranda
    Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Med Chem 48:8220-8. 2005
    ..These data suggest that primary amine NONOates may be useful as HNO donors in complement to the existing series of secondary amine NONOates, which are well-characterized NO donors...
  47. ncbi Activation of CCAAT/enhancer-binding protein (C/EBP) alpha expression by C/EBP beta during adipogenesis requires a peroxisome proliferator-activated receptor-gamma-associated repression of HDAC1 at the C/ebp alpha gene promoter
    Ying Zuo
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 281:7960-7. 2006
    ....
  48. ncbi Biochemical and molecular characterization of an azoreductase from Staphylococcus aureus, a tetrameric NADPH-dependent flavoprotein
    Huizhong Chen
    Division of Microbiology, National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
    Microbiology 151:1433-41. 2005
    ..4 microM min(-1) (mg protein)(-1). Azo1 was also able to metabolize Orange II, Amaranth, Ponceau BS and Ponceau S azo dyes. Azo1 represents the first azoreductase to be identified and characterized from human skin microflora...
  49. ncbi Chemistry of the diazeniumdiolates: Z right harpoon over left harpoon E isomerism
    Yan ni Wang
    Advanced Biomedical Computing Center, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Am Chem Soc 127:5388-95. 2005
    ....
  50. ncbi Chemistry of the diazeniumdiolates. O- versus N-alkylation of the RNH[N(O)NO](-) ion
    Joseph E Saavedra
    Contribution from the Basic Research Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Am Chem Soc 126:12880-7. 2004
    ..As one example, an agent with R = isopropyl and R' = beta-D-glucosyl was prepared and shown to generate nitric oxide in the presence of glucosidase at pH 5...
  51. ncbi Computerized image analysis vs semiquantitative scoring in evaluation of kidney allograft fibrosis and prognosis
    Stale Sund
    Department Institute of Pathology, Rikshospitalet University Hospital, Oslo, Norway
    Nephrol Dial Transplant 19:2838-45. 2004
    ..In the present study, we evaluated allograft cortical interstitial fibrosis, and compared semiquantitative assessment with computerized image analysis of Sirius red-stained collagen in prediction of graft prognosis...
  52. ncbi Expression and characteristics of the gene encoding azoreductase from Rhodobacter sphaeroides AS1.1737
    Yan Bin
    School of Environmental and Biological Science and Technology, Dalian University of Technology, 116023, PR China
    FEMS Microbiol Lett 236:129-36. 2004
    ..The presence of a hydrazo-intermediate was identified, which provided a convincing evidence for the assumption that azo dyes were degraded via an incomplete reduction stage...
  53. ncbi JS-K, a nitric oxide prodrug, induces cytochrome c release and caspase activation in HL-60 myeloid leukemia cells
    Vidya Udupi
    Medical Oncology, University of Utah, Salt Lake City, UT, USA
    Leuk Res 30:1279-83. 2006
    ..Treatment with JS-K resulted in activation of Caspase (Casp) 9, Casp 3 and Casp 8. JS-K constitutes a promising lead for a new class of anti-leukemic agents...
  54. doi Comparative analysis of membranous proteomics of Shewanella decolorationis S12 grown with azo compound or Fe (III) citrate as sole terminal electron acceptor
    Bo Wang
    Guangdong Institute of Microbiology, Guangzhou, 510070, China
    Appl Microbiol Biotechnol 86:1513-23. 2010
    ..OmpA family protein SO_3545 was detected to be specific to Fe (III) respiration. Furthermore, ArgF, SdhA, and HoxK were expressed markedly in both amaranth- and Fe (III) citrate-grown cultures compared with oxygen-grown cultures...
  55. doi Two different electron transfer pathways may involve in azoreduction in Shewanella decolorationis S12
    Xingjuan Chen
    South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China
    Appl Microbiol Biotechnol 86:743-51. 2010
    ....
  56. pmc Respiration and growth of Shewanella decolorationis S12 with an Azo compound as the sole electron acceptor
    Yiguo Hong
    Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou 510070, China
    Appl Environ Microbiol 73:64-72. 2007
    ..These findings not only expand the number of potential electron acceptors known for microbial energy conservation but also elucidate the mechanisms of microbial anaerobic azoreduction...
  57. ncbi Fe(III)-enhanced Azo Reduction by Shewanella decolorationis S12
    Meiying Xu
    Guangdong Institute of Microbiology, 100 Central Xianlie Road, Guangzhou 510070, People s Republic of China
    Appl Microbiol Biotechnol 74:1342-9. 2007
    ..The respiratory electron transport chain inhibitors metyrapone, dicumarol, and stigmatellin showed significantly different effects on Fe(III) reduction than on azo dye decolorization...
  58. ncbi Effects of electron donors and acceptors on anaerobic reduction of azo dyes by Shewanella decolorationis S12
    Yiguo Hong
    South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
    Appl Microbiol Biotechnol 74:230-8. 2007
    ..These findings impact on the understanding of the mechanism of bacterial anaerobic azoreduction and have implication for improving treatment methods of wastewater contaminated by azo dyes...
  59. pmc Anaerobic metabolism of 1-amino-2-naphthol-based azo dyes (Sudan dyes) by human intestinal microflora
    Haiyan Xu
    Division of Microbiology, National Center for Toxicological Research, U S FDA, 3900 NCTR Rd, Jefferson, AR 72079 9502, USA
    Appl Environ Microbiol 73:7759-62. 2007
    ..These data indicate that human intestinal bacteria are able to reduce Sudan dyes to form potentially carcinogenic aromatic amines...
  60. ncbi Molecular cloning, characterisation and ligand-bound structure of an azoreductase from Pseudomonas aeruginosa
    Chan Ju Wang
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK
    J Mol Biol 373:1213-28. 2007
    ..The structure of the ligand-bound protein also highlights the pi-stacking interactions between FMN and the azo substrate...
  61. doi Identification of an uptake hydrogenase for hydrogen-dependent dissimilatory azoreduction by Shewanella decolorationis S12
    Yi guo Hong
    Key Laboratory of Tropical Marine Environment Dynamics LED, South China Sea Institute of Oceanography, Chinese Academy of Sciences, Guangzhou, People s Republic of China
    Appl Microbiol Biotechnol 80:517-24. 2008
    ..azo-reducing bacterium of Shewanella genus, can grow by coupling the oxidation of hydrogen to the reduction of azo compounds as the sole electron acceptor, indicating that an uptake hydrogenase is an important component for electron ..
  62. ncbi A novel role for human sulfiredoxin in the reversal of glutathionylation
    Victoria J Findlay
    Department of Molecular and Cellular Pharmacology, Medical University of South Carolina, Jonathan Lucas Street, Charleston, SC 29425, USA
    Cancer Res 66:6800-6. 2006
    ..This novel deglutathionylation function of sulfiredoxin suggests it has a central role in redox control with potential implications in cell signaling...
  63. ncbi Reactive azo dye reduction by Shewanella strain J18 143
    Carolyn I Pearce
    Williamson Research Centre for Molecular Environmental Science and School of Earth, Atmospheric and Environmental Sciences, The University of Manchester, Manchester M13 9PL, UK
    Biotechnol Bioeng 95:692-703. 2006
    ....
  64. pmc Chemical synthesis of oligodeoxyribonucleotides containing N3- and O4-carboxymethylthymidine and their formation in DNA
    Jianshuang Wang
    Department of Chemistry, University of California, Riverside, CA 92521 0403, USA
    Nucleic Acids Res 37:336-45. 2009
    ....
  65. ncbi Recent advances in azo dye degrading enzyme research
    Huizhong Chen
    Division of Microbiology, National Center for Toxicological Research, U S FDA, 3900 NCTR Rd, Jefferson, AR 72079 9502, USA
    Curr Protein Pept Sci 7:101-11. 2006
    ..In this review, structures and carcinogenicity of azo colorants, protein structure, enzymatic function, and substrate specificity, as well as application of the azo dyes and azoreductases will be discussed...
  66. pmc Mechanism of pH-dependent decomposition of monoalkylamine diazeniumdiolates to form HNO and NO, deduced from the model compound methylamine diazeniumdiolate, density functional theory, and CBS-QB3 calculations
    Andrew S Dutton
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA
    Inorg Chem 45:2448-56. 2006
    ..The production of NO at lower pH is predicted to result from fragmentation of the amide/NO adduct upon protonation of the amine nitrogen...
  67. ncbi Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor
    Sun Hee Kim
    School of Environmental Science and Engineering, Pohang University of Science and Technology, Pohang 790 784, South Korea
    Mol Pharmacol 69:1871-8. 2006
    ..Taken together, these results demonstrate that this novel compound, CH-223191, may be a useful agent for the study of AhR-mediated signal transduction and the prevention of TCDD-associated pathology...
  68. ncbi Carcinogenicity of azo colorants: influence of solubility and bioavailability
    Klaus Golka
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
    Toxicol Lett 151:203-10. 2004
    ..This is not the case for 3,3'-dichlorobenzidine-based azo pigments...
  69. ncbi Application of redox mediators to accelerate the transformation of reactive azo dyes in anaerobic bioreactors
    F P van der Zee
    Wageningen University, Agrotechnology and Food Sciences, Sub Department of Environmental Technology, P O Box 8129, 6700 EV, Wageningen, The Netherlands
    Biotechnol Bioeng 75:691-701. 2001
    ....
  70. ncbi Basic and applied aspects in the microbial degradation of azo dyes
    A Stolz
    Institut fur Mikrobiologie der Universitat Stuttgart, Germany
    Appl Microbiol Biotechnol 56:69-80. 2001
    ..These reductive processes have been described for some aerobic bacteria, which can grow with (rather simple) azo compounds. These specifically adapted microorganisms synthesize true azoreductases, which reductively cleave the azo ..
  71. ncbi Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos
    H Ando
    Laboratory for Developmental Gene Regulation, Brain Science Institute, RIKEN (The Institute of Physical and Chemical Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
    Nat Genet 28:317-25. 2001
    ....
  72. ncbi JS-K, a novel non-ionic diazeniumdiolate derivative, inhibits Hep 3B hepatoma cell growth and induces c-Jun phosphorylation via multiple MAP kinase pathways
    Zhenggang Ren
    Liver Cancer Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Cell Physiol 197:426-34. 2003
    ..The data support the idea that prolonged MAPK activation by JS-K action is important in mediating its growth-inhibitory actions. JS-K thus represents a promising platform for novel growth inhibitory analog synthesis...
  73. ncbi Effects of different quinoid redox mediators on the anaerobic reduction of azo dyes by bacteria
    Jorg Rau
    Institut fur Mikrobiologie, Universitat Stuttgart, Germany
    Environ Sci Technol 36:1497-504. 2002
    ..The addition of AQS or lawsone also increased the ability of unacclimated sewage sludge to reduce azo dyes. Chemically pure lawsone could be replaced by the powdered leaves of the henna plant which contain significant amounts of lawsone...
  74. pmc Molecular cloning and characterization of the gene coding for the aerobic azoreductase from Xenophilus azovorans KF46F
    Silke Blümel
    Institut fur Mikrobiologie der Universitat Stuttgart, 70569 Stuttgart, Germany
    Appl Environ Microbiol 68:3948-55. 2002
    ..The turnover of several industrially relevant azo dyes by cell extracts from the recombinant E. coli strain was demonstrated...
  75. pmc A new alkali-thermostable azoreductase from Bacillus sp. strain SF
    Jürgen Maier
    Department of Environmental Biotechnology, Graz University of Technology, A 8010 Graz, Austria
    Appl Environ Microbiol 70:837-44. 2004
    ..Those dyes with NO2 substituents, especially in the ortho position, were degraded fastest, while analogues with a methyl substitution showed the lowest degradation rates...
  76. ncbi Cloning and characterization of the gene coding for the aerobic azoreductase from Pigmentiphaga kullae K24
    S Blumel
    Institut fur Mikrobiologie der Universitat Stuttgart, Allmandring 31, 70569, Stuttgart, Germany
    Appl Microbiol Biotechnol 62:186-90. 2003
    ..The azoreductase was heterologously expressed in Escherichia coli and shown to convert the sulfonated azo dye Orange I and furthermore Magneson II [4-(4-nitrophenylazo)-1-naphthol]...
  77. ncbi Azo dye decolourisation by anaerobic granular sludge
    F P van der Zee
    Department of Agrotechnology and Food Sciences, Wageningen University, The Netherlands
    Chemosphere 44:1169-76. 2001
    ..Reducing agents (e.g., sulphide) in sludge play an important role. The presence of anaerobic biomass is probably beneficial for maintaining the pools of these reduced compounds...
  78. ncbi The cytotoxicity of DNA carboxymethylation and methylation by the model carboxymethylating agent azaserine in human cells
    M O'Driscoll
    Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, London, UK
    Carcinogenesis 20:1855-62. 1999
    ....
  79. pmc Purification and characterization of Clostridium perfringens 120-kilodalton collagenase and nucleotide sequence of the corresponding gene
    O Matsushita
    Department of Microbiology, Kagawa Medical School, Japan
    J Bacteriol 176:149-56. 1994
    ..Vibrio alginolyticus collagenase and Achromobacter lyticus protease I showed significant homology with the 120-kDa collagenase of C. perfringens, suggesting that these three enzymes are evolutionarily related...
  80. pmc Reduction of azo dyes by redox mediators originating in the naphthalenesulfonic acid degradation pathway of Sphingomonas sp. strain BN6
    A Keck
    Institut für Industrielle Genetik, Universitat Stuttgart, Germany
    Appl Environ Microbiol 63:3684-90. 1997
    ..Thus, the decomposition products of 1,2-dihydroxynaphthalene are suggested to act as redox mediators which are able to anaerobically shuttle reduction equivalents from the cells to the extracellular azo dye...
  81. ncbi Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug
    Victoria J Findlay
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Pharmacol 65:1070-9. 2004
    ..Selective inhibition studies showed that the activation of JNK and p38 were critical to the cytotoxic effects of PABA/NO. Finally, PABA/NO produced antitumor effects in a human ovarian cancer model grown in SCID mice...
  82. ncbi Diazeniumdiolate ions as leaving groups in anomeric displacement reactions: a protection-deprotection strategy for ionic diazeniumdiolates
    Brett M Showalter
    Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Am Chem Soc 127:14188-9. 2005
    ....
  83. ncbi Degradation of commercial azo dye reactive Black B in photo/ferrioxalate system
    Yao Hui Huang
    Department of Chemical Engineering, National Cheng Kung University, Tainan City 701, Taiwan
    J Hazard Mater 140:382-8. 2007
    ..Applying oxalate in such a photo process increases both the RBB removal efficiency and the COD removal from 68% and 21% to 99.8% and 71%, respectively...
  84. ncbi Metabolism of azo dyes by Lactobacillus casei TISTR 1500 and effects of various factors on decolorization
    Phisit Seesuriyachan
    Faculty of Agro Industry, Department of Biotechnology, Chiang Mai University, Chiang Mai 50100, Thailand
    Water Res 41:985-92. 2007
    ..The optimal conditions for the decolorization of methyl orange by the Lactobacillus casei TISTR 1500 are incubation at 35 degrees C and pH 6 with sucrose provided as the energy source...
  85. ncbi Degradation and mineralization of Direct Blue 71 in a circulating upflow reactor by UV/TiO2 process and employing a new method in kinetic study
    J Saien
    Department of Applied Chemistry, University of Bu Ali Sina, Hamedan 65174, Iran
    J Hazard Mater 144:506-12. 2007
    ....
  86. ncbi Biocalalyst effects of immobilized anthraquinone on the anaerobic reduction of azo dyes by the salt-tolerant bacteria
    Jianbo Guo
    School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116023, PR China
    Water Res 41:426-32. 2007
    ..The experiments explored a great improvement of the redox mediator application and the new bio-treatment concept...
  87. ncbi Sonophotocatalytic degradation of congo red and methyl orange in the presence of TiO2 as a catalyst
    Néstor Javier Bejarano-Pérez
    Departamento de Quimica, Facultad de Ciencias, Universidad Nacional de Colombia, Edificio 451, Bogota, Colombia
    Ultrason Sonochem 14:589-95. 2007
    ....
  88. ncbi Investigation on the sonocatalytic degradation of acid red B in the presence of nanometer TiO2 catalysts and comparison of catalytic activities of anatase and rutile TiO2 powders
    Jun Wang
    Department of Chemistry, Liaoning University, Shenyang 110036, PR China
    Ultrason Sonochem 14:545-51. 2007
    ..Hence, the method of sonocatalytic degradation for organic pollutants in the presence of nanometer anatase TiO(2) powder is expected to be promising as an advisable choice for the treatment of organic wastewaters in future...
  89. ncbi Performance of COD removal from acid scarlet BS-containing solution in a novel packed-bed hollow-tube photocatalytic (PHP) reactor
    Ya Xiong
    School of Chemistry and Chemical Engineering, Zhongshan University, Guangzhou, PR China
    J Environ Sci Health A Tox Hazard Subst Environ Eng 38:935-47. 2003
    ....
  90. ncbi Ozonation of dyes and textile wastewater in a rotating packed bed
    Neng Chou Shang
    Graduate Institute of Environmental Engineering, National Taiwan University, Taipei, Taiwan
    J Environ Sci Health A Tox Hazard Subst Environ Eng 41:2299-310. 2006
    ..The performance evaluation of ozonation in the rotating packed bed indicated that the higher water flow rate, gas ozone concentration and rotational rotating speed would increase the efficiency of mineralization...
  91. ncbi Comparison of dye degradation efficiency using ZnO powders with various size scales
    Huihu Wang
    State Key Laboratory of Plastic Forming Simulation and Mould Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
    J Hazard Mater 141:645-52. 2007
    ..Moreover, the effect of catalyst loading, pH value and the initial dye concentration on the final degradation efficiency were discussed through the photocatalytic experiments using 50nm ZnO nanoparticle as photocatalyst...
  92. ncbi Studies on photodegradation of two commercial dyes in aqueous phase using different photocatalysts
    S K Kansal
    Department of Chemical Engineering and Technology, Panjab University, Chandigarh 160014, India
    J Hazard Mater 141:581-90. 2007
    ..5g/l) than MO (1g/l) under similar conditions. The performance of photocatalytic system employing ZnO/solar light was observed to be better than ZnO/UV system...
  93. ncbi Influence of varying reacting conditions in the degradation of azo dye using immobilized TiO2 photocatalyst
    A Aris
    Department of Environmental Engineering, Faculty of Civil Engineering, Universiti Teknologi Malaysia, Skudai, Johore
    Water Sci Technol 46:255-62. 2002
    ..Using the dye concentration of 2.5 x 10(-4) M (H2O2 = 10(-2) M, lambda = 254 nm, pH = 11), gives a degradation of 93.2%. At dye concentration of 10(-3) M, the performance was reduced to 53.1%...
  94. ncbi Decolorization of the textile dyes by newly isolated bacterial strains
    Kuo Cheng Chen
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan, ROC
    J Biotechnol 101:57-68. 2003
    ..Decolorization appeared to proceed primarily by biological degradation...
  95. ncbi Treatment of dye wastewater by using photo-catalytic oxidation with sonication
    Akinori Maezawa
    Department of Materials Science and Chemical Engineering, Shizuoka University, 3 5 1, Johoku, Hamamatsu 432 8561, Japan
    Ultrason Sonochem 14:615-20. 2007
    ..From these results, it is considered that the photocatalysis with sonication is most effective for the decomposition of dye in the three processes in this study...
  96. ncbi Discoloration of a red cationic dye by supported TiO(2) photocatalysis
    B Mounir
    Ecole Supérieure de Technologie de Safi, Universite Cadi Ayyad, BP 89, Route Dar Si Aissa, Safi, Morocco
    J Hazard Mater 148:513-20. 2007
    ..Under sunlight the COD removal yield for textile wastewater reaches 33% with Catalyst I against 93% with Catalyst II...
  97. doi Photocatalytic and combined anaerobic-photocatalytic treatment of textile dyes
    F Harrelkas
    Laboratoire des Sciences du Genie Chimique, CNRS, Nancy University, INPL, 1 rue Grandville, BP 20451, 54001 Nancy Cedex, France
    Chemosphere 72:1816-22. 2008
    ..The results demonstrate that photocatalysis can be used as a pre- or post-treatment method to biological anaerobic treatment of dye-containing textile wastewater...
  98. ncbi Photocatalytic degradation of azo dye in TiO2 suspended solution
    C H Hung
    Department of Environmental Engineering, Foo-Yin Institute of Technology, 151 Chung-Hsueh Road, Taliao 831, Kaoshiung Hsien, Taiwan
    Water Sci Technol 43:313-20. 2001
    ..The reaction rates were proportional to TiO2 concentration and light intensity with the power order of 0.726 and 0.734, respectively...
  99. doi Cross-linked quaternary chitosan as an adsorbent for the removal of the reactive dye from aqueous solutions
    Sirlei Rosa
    Departamento de Engenharia Quimica, Universidade Federal de Santa Catarina, Florianopolis 88040 900, Santa Catarina, Brazil
    J Hazard Mater 155:253-60. 2008
    ..The results obtained demonstrate that the adsorbent material could be utilized to remove dyes from textile effluents independent of the pH of the aqueous medium...
  100. doi Photocatalytic degradation of the Acid Blue 113 textile azo dye in aqueous suspensions of four commercialized TiO(2) samples
    Ghanem Zayani
    Laboratory for the Treatment and Recycling of Used Waters, INRST, Hammam Lif, Tunisia
    J Environ Sci Health A Tox Hazard Subst Environ Eng 43:202-9. 2008
    ....
  101. doi Photocatalytic degradation of Orange G on nitrogen-doped TiO2 catalysts under visible light and sunlight irradiation
    Jianhui Sun
    Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, College of Chemistry and Environmental Science, No 46, Jianshe Road, Xinxiang, Henan Province 453007, PR China
    J Hazard Mater 155:312-9. 2008
    ..Under visible light and sunlight, the optimal solution pH was both 2.0, while the optimal dosage of H2O2 was 5.0 and 15.0 mmol/l, respectively...

Research Grants97

  1. SECRETION FROM ADIPOSE CELLS
    Konstantin Kandror; Fiscal Year: 2003
    ..abstract_text> ..
  2. Development of JS-K as an anti-leukemic agent
    Paul Shami; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: There is a great need for new drugs to treat Cancer. Work done in this project will develop a new drug called JS-K for the treatment of Cancer. ..
  3. Radiation Therapy Impact on Structure/Mechanics of Teeth
    Mary Walker; Fiscal Year: 2007
    ..A key strength of this project is the associated feedback mechanism that relates the clinical problem to both clinical and laboratory data, the integration of scientific principles into clinical practice. ..
  4. ALKALOID SYNTHESIS VIA 2-AZAALLYL ANION CYCLOADDITIONS
    William Pearson; Fiscal Year: 1999
    ..The issue of stereocontrol, both absolute and relative is to be explored in detail. Information on the preferred transition state for these cycloadditions is to obtained as a result of these studies. ..
  5. Understanding the mechanism of radiotherapy-induced dentition breakdown
    Yong Wang; Fiscal Year: 2010
    ..Thus, future improvements for preventing and treating post-radiation dentition breakdown depend on new knowledge of the underlying mechanism of radiation-induced damage at the tooth level. ..
  6. Molecular/Mechanical Imaging of Dentin Bonding Substrate
    Yong Wang; Fiscal Year: 2007
    ..Results from this work will provide critical, new insight into failure mechanisms at the dentin/adhesive interface; failure that can ultimately lead to premature breakdown of the composite restoration. ..
  7. Purification of Optically Labeled Oligonucleotides
    William Pearson; Fiscal Year: 2004
    ..Initial work will focus on oligonucleotide probe purification. ..
  8. BIOSYNTHESIS OF SOME MICROBIAL METABOLITES
    Ronald Parry; Fiscal Year: 2003
    ..The final goal is to overproduce and study the sulfur insertion and dioxygenase proteins in vitro. ..
  9. Dentin/Adhesive Interface Structure/Property Imaging
    Yong Wang; Fiscal Year: 2006
    ....
  10. ALKALOID SYNTHESIS VIA (3+2) CYCLOADDITIONS
    William Pearson; Fiscal Year: 2002
    ..Tandem processes that involve the combination of (3+2) cycloaddition followed by additional reactions that lead to a second or third ring formation or a rearrangement are also being studied. ..
  11. Effects of Antioxidants on Human Macular Pigments
    Kyung Jin Yeum; Fiscal Year: 2006
    ....
  12. BIOSYNTHESIS OF SOME MICROBIAL METABOLITES
    Ronald Parry; Fiscal Year: 2007
    ..Future investigations of sparsomycin will focus on cloning the sparsomycin resistance gene from S. sparsogenes to understand the mechanism of self-resistance in this organism and to gain access to the biosynthetic genes. ..
  13. Purification of Oligonucleotides and Nucleoside Triphosphates
    William Pearson; Fiscal Year: 2007
    ..The proposed work seeks to further develop an entirely new method for oligonucleotide purification, thus streamlining the development and production of these crucial substances. ..
  14. BIOSYNTHESIS AND METABOLISM OF CYCLOPENTANOIDS
    Ronald Parry; Fiscal Year: 2001
    ..The potential use of the CmaA gene for construction of hybrid peptide antibiotics containing L-alloisoleucine or coronamic acid will also be explored, using surfactin biosynthesis in B. subtilis as a model system. ..
  15. NOVEL GLYCOSIDASE INHIBITORS AS ANTICANCER AGENTS
    William Pearson; Fiscal Year: 2001
    ..g., affinity matrices). ..
  16. BIOSYNTHESIS OF CYCLOPENTANOIDS
    Ronald Parry; Fiscal Year: 1993
    ..Polyoximic acid is a component of the polyoxins, a group of antifungal antibiotics produced by S. cacaoi var. asoensis...
  17. BIOSYNTHESIS OF CYCLOPENTANOIDS
    Ronald Parry; Fiscal Year: 1991
    ..Future investigations of coronatine bio- synthesis will employ precursor incorporation experiments to probe both the mechanism of assembly of the polyketide and the mechanism of cyclopropane ring formation...
  18. BIOSYNTHESIS OF SOME MICROBIAL METABOLITES
    Ronald Parry; Fiscal Year: 1999
    ....
  19. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2007
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  20. CORE--Histopathology and Microbiology
    HONG CHU; Fiscal Year: 2007
    ..pneumoniae treated with surfactant protein-A (SP-A) Thus, Core B will be an integral part of the Program Project Grant and in doing so will have the projects function at a high standard. ..
  21. Role of PDZK1 in lipid metabolism and atherosclerosis.
    Olivier Kocher; Fiscal Year: 2007
    ....
  22. GENETIC TARGETS OF NITRIC OXIDE IN LEUKEMIA CELLS
    Paul Shami; Fiscal Year: 2004
    ..This work will help understand the mechanism by which NO affects hematopoietic cell growth and differentiation and may constitute the basis for the development of novel strategies for the treatment of AML. ..
  23. INSULIN REGULATION OF CELL NUTRITION
    Konstantin Kandror; Fiscal Year: 2002
    ..Eventually, this work will provide us with a detailed picture of intracellular protein traffic in adipocytes. ..
  24. INSULIN REGULATION OF CELL NUTRITION
    Konstantin Kandror; Fiscal Year: 2007
    ..Thus, we propose to study the biological role of sortilin in adipocytes using the antisense technique. ..