mexiletine

Summary

Summary: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.

Top Publications

  1. pmc Mexiletine for symptoms and signs of myotonia in nondystrophic myotonia: a randomized controlled trial
    Jeffrey M Statland
    Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA
    JAMA 308:1357-65. 2012
  2. ncbi Partial expression defect for the SCN5A missense mutation G1406R depends on splice variant background Q1077 and rescue by mexiletine
    Bi Hua Tan
    Dept of Medicine, Univ of Wisconsin, 600 Highland Ave H6 349, Madison, WI 53792, USA
    Am J Physiol Heart Circ Physiol 291:H1822-8. 2006
  3. ncbi The effect of mexiletine on the level of lipid peroxidation and apoptosis of endothelium following experimental subarachnoid hemorrhage
    Orhan Sen
    Department of Neurosurgery, Baskent University, Ankara, Turkey
    Neurol Res 28:859-63. 2006
  4. pmc Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial
    Christopher L Wu
    Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Anesthesiology 109:289-96. 2008
  5. pmc Mexiletine is an effective antimyotonia treatment in myotonic dystrophy type 1
    E L Logigian
    Department of Neurology, University of Rochester, Rochester, NY, USA
    Neurology 74:1441-8. 2010
  6. ncbi Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative
    J F Desaphy
    Unit of Pharmacology, Faculty of Pharmacy, University of Bari, Italy
    Neurology 57:1849-57. 2001
  7. ncbi Mexiletine and lidocaine suppress the excitability of dorsal horn neurons
    Andrea Olschewski
    Department of Anesthesiology, Intensive Care Medicine, Pain Therapy, University Clinic Giessen and Marburg GmbH, Giessen, Germany
    Anesth Analg 109:258-64. 2009
  8. ncbi Effect of mexiletine on vincristine-induced painful neuropathy in mice
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 536:123-7. 2006
  9. ncbi The preventive effect of mexiletine on cerebral ischemic injury following experimental middle cerebral artery occlusion
    Cem Yilmaz
    Baskent University, Neurosurgery Department, Ankara, Turkey
    Turk Neurosurg 19:367-73. 2009
  10. ncbi Mexiletine-responsive erythromelalgia due to a new Na(v)1.7 mutation showing use-dependent current fall-off
    Jin Sung Choi
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
    Exp Neurol 216:383-9. 2009

Research Grants

Detail Information

Publications206 found, 100 shown here

  1. pmc Mexiletine for symptoms and signs of myotonia in nondystrophic myotonia: a randomized controlled trial
    Jeffrey M Statland
    Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA
    JAMA 308:1357-65. 2012
    ..Patients experience delayed muscle relaxation causing functionally limiting stiffness and pain. Mexiletine-induced sodium channel blockade reduced myotonia in small studies; however, as is common in rare diseases, ..
  2. ncbi Partial expression defect for the SCN5A missense mutation G1406R depends on splice variant background Q1077 and rescue by mexiletine
    Bi Hua Tan
    Dept of Medicine, Univ of Wisconsin, 600 Highland Ave H6 349, Madison, WI 53792, USA
    Am J Physiol Heart Circ Physiol 291:H1822-8. 2006
    ..channels in both backgrounds were transfected into HEK-293 cells and incubated for up to 72 h with and without mexiletine. At 8 h, neither current nor cell surface expression was observed for the mutant in either background, but both ..
  3. ncbi The effect of mexiletine on the level of lipid peroxidation and apoptosis of endothelium following experimental subarachnoid hemorrhage
    Orhan Sen
    Department of Neurosurgery, Baskent University, Ankara, Turkey
    Neurol Res 28:859-63. 2006
    ..b>Mexiletine blocks sodium and calcium channels and activates ATP-sensitive K(+) channels...
  4. pmc Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial
    Christopher L Wu
    Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Anesthesiology 109:289-96. 2008
    ..Stump and phantom pains are debilitating sequelae of amputations that are often resistant to treatment. The efficacy of pharmacologic therapies, including opioids and sodium channel blockers, for postamputation pain is uncertain...
  5. pmc Mexiletine is an effective antimyotonia treatment in myotonic dystrophy type 1
    E L Logigian
    Department of Neurology, University of Rochester, Rochester, NY, USA
    Neurology 74:1441-8. 2010
    To determine if mexiletine is safe and effective in reducing myotonia in myotonic dystrophy type 1 (DM1).
  6. ncbi Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative
    J F Desaphy
    Unit of Pharmacology, Faculty of Pharmacy, University of Bari, Italy
    Neurology 57:1849-57. 2001
    ..and periodic paralysis caused by sodium channel mutations show variable responses to the anti-myotonic drug mexiletine. OBJECTIVE: To investigate whether variability among sodium channel mutants results from differences in drug ..
  7. ncbi Mexiletine and lidocaine suppress the excitability of dorsal horn neurons
    Andrea Olschewski
    Department of Anesthesiology, Intensive Care Medicine, Pain Therapy, University Clinic Giessen and Marburg GmbH, Giessen, Germany
    Anesth Analg 109:258-64. 2009
    ..Thus, we investigated the effects of the Na+ channel blockers mexiletine and lidocaine on sensory spinal dorsal horn neurons.
  8. ncbi Effect of mexiletine on vincristine-induced painful neuropathy in mice
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 536:123-7. 2006
    In the present study, we examined the effect of mexiletine on vincristine-induced thermal hyperalgesia in mice. Mice were intraperitoneally treated with vincristine at a dose of 0...
  9. ncbi The preventive effect of mexiletine on cerebral ischemic injury following experimental middle cerebral artery occlusion
    Cem Yilmaz
    Baskent University, Neurosurgery Department, Ankara, Turkey
    Turk Neurosurg 19:367-73. 2009
    Previous studies demonstrated that mexiletine has some important features in the prevention of ischemic brain injury such as sodium and calcium canal blockage and free radical occurrence...
  10. ncbi Mexiletine-responsive erythromelalgia due to a new Na(v)1.7 mutation showing use-dependent current fall-off
    Jin Sung Choi
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
    Exp Neurol 216:383-9. 2009
    ..to pharmacotherapy, although occasional reports document patients as showing partial relief with lidocaine or mexiletine. A 7-year-old girl, with a two-year history of symmetric burning pain and erythema in her hands and feet, was ..
  11. ncbi The cellular electrophysiologic effect of a new amiodarone like antiarrhythmic drug GYKI 16638 in undiseased human ventricular muscle: comparison with sotalol and mexiletine
    M Opincariu
    Department of Pharmacology and Pharmacotherapy, Albert Szent Gyorgyi Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary
    Curr Med Chem 9:41-6. 2002
    ..effect of GYKI 16638, a new antiarrhythmic compound was studied and compared with that of sotalol and mexiletine in undiseased human right ventricular muscle preparation by applying the conventional microelectrode technique...
  12. ncbi Role of K+ channels in augmented relaxations to sodium nitroprusside induced by mexiletine in rat aortas
    H Kinoshita
    Department of Anesthesia, Japanese Red Cross Society, Wakayama Medical Center, Japan
    Anesthesiology 92:813-20. 2000
    A class Ib antiarrhythmic drug, mexiletine, augments relaxations produced by adenosine triphosphate (ATP) sensitive K+ channel openers in isolated rat aortas, suggesting that it produces changes in the vasodilation mediated by ATP-..
  13. pmc Non-dystrophic myotonia: prospective study of objective and patient reported outcomes
    Jaya R Trivedi
    Department of Neurology and Neurotherapeutics, UT Southwestern Medical Centre, Dallas, TX 75390, USA
    Brain 136:2189-200. 2013
    ....
  14. ncbi Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator
    Martyn Frederickson
    Astex Therapeutics Ltd, 436 Cambridge Science Park, Milton Road, Cambridge, CB4 0QA, United Kingdom
    J Med Chem 51:183-6. 2008
    ..The (R)-enantiomer of the orally active drug mexiletine 5 (a fragment hit from X-ray crystallographic screening) was the chemical starting point...
  15. ncbi Neuroprotective effect of mexiletine in the central nervous system of diabetic rats
    Ozkan Ates
    Inonu University, School of Medicine, Department of Neurosurgery, Malatya, Turkey
    Mol Cell Biochem 286:125-31. 2006
    ..In the present study we investigated the possible neuroprotective effect of mexiletine against streptozotocin-induced hyperglycaemia in the rat brain and spinal cord...
  16. ncbi Intravenous lidocaine and mexiletine in the management of trigeminal autonomic cephalalgias
    Michael J Marmura
    Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Curr Pain Headache Rep 14:145-50. 2010
    Lidocaine and mexiletine are class 1B antiarrhythmic drugs that act on sodium channels...
  17. ncbi Refractory erythromelalgia of the ears: response to mexiletine
    Alejandra C Vivas
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    Am J Otolaryngol 32:168-70. 2011
    ..of the ears in a patient who has been refractory to multiple therapies and in whom relief of symptoms was achieved with the use of mexiletine. A review of clinical presentation, pathophysiology, and therapeutic options are presented.
  18. ncbi Mexiletine in the symptomatic treatment of diabetic peripheral neuropathy
    J M Wright
    School of Medicine, University of Missouri, Kansas City 64108, USA
    Ann Pharmacother 31:29-34. 1997
    To evaluate the efficacy and safety of mexiletine in the symptomatic treatment of diabetic peripheral neuropathy (DPN).
  19. ncbi Enantioselective drug-protein interaction between mexiletine and plasma protein
    Lushan Yu
    Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
    J Pharm Pharmacol 64:792-801. 2012
    This study examined the interaction of mexiletine enantiomers with human plasma, human serum albumin (HSA), and human α1-acid glycoprotein (hAGP), and characterized the binding modes of mexiletine enantiomers with hAGP in the molecular ..
  20. pmc Stereoselective binding of mexiletine and ketoprofen enantiomers with human serum albumin domains
    Da Shi
    Department of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
    Acta Pharmacol Sin 33:710-6. 2012
    To investigate the stereoselective binding of mexiletine or ketoprofen enantiomers with different recombinant domains of human serum albumin (HSA).
  21. ncbi Mexiletine. A review of its therapeutic use in painful diabetic neuropathy
    B Jarvis
    Adis International Limited, Auckland, New Zealand
    Drugs 56:691-707. 1998
    b>Mexiletine is an orally active local anaesthetic agent which is structurally related to lidocaine (lignocaine) and has been used for alleviating neuropathic pain of various origins...
  22. ncbi A trafficking defective, Brugada syndrome-causing SCN5A mutation rescued by drugs
    Carmen R Valdivia
    Department of Medicine and Physiology, University of Wisconsin, Madison, WI, USA
    Cardiovasc Res 62:53-62. 2004
    ..Mutations in SCN5A cause arrhythmia syndromes including Brugada syndrome (BrS) and congenital long QT syndrome subtype 3 (LQT3). Here, we report a trafficking defective BrS-causing SCN5A mutation that was drug-rescued...
  23. ncbi New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse
    Annamaria De Luca
    Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, Via Orabona 4, Campus, 70125 Bari, Italy
    Neuromuscul Disord 14:405-16. 2004
    The antimyotonic activity of chiral derivatives of mexiletine and tocainide, selected as potent use-dependent blockers of skeletal muscle sodium channels, was evaluated in vivo acutely in myotonic ADR mice...
  24. ncbi The use-dependent sodium channel blocker mexiletine is neuroprotective against global ischemic injury
    K E Hewitt
    Loeb Health Research Institute, Division of Neuroscience, Ottawa Hospita -Civic Campus, University of Ottawa, 725 Parkdale Avenue, Ont, K1Y 4K9, Ottawa, Canada
    Brain Res 898:281-7. 2001
    ..This study investigates mexiletine, a use-dependent sodium channel blocker known to provide significant ischemic neuroprotection to white matter, ..
  25. pmc Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents
    M De Bellis
    Unit of Pharmacology, Department of Pharmacobiology, University of Bari, Bari, Italy
    Br J Pharmacol 149:300-10. 2006
    b>Mexiletine (Mex), an orally effective antiarrhythmic agent used to treat ventricular arrhythmias, has also been found to be effective for myotonia and neuropathic pain...
  26. ncbi Trafficking defects and gating abnormalities of a novel SCN5A mutation question gene-specific therapy in long QT syndrome type 3
    Yanfei Ruan
    Cardiovascular Genetics Program, Leon H Charney Division of Cardiology, New York University School of Medicine, New York, NY, USA
    Circ Res 106:1374-83. 2010
    ..Sodium channel blockers are used as gene-specific treatments in long-QT syndrome type 3, which is caused by mutations in the sodium channel gene (SCN5A). Response to treatment is influenced by biophysical properties of mutations...
  27. ncbi Mexiletine reverses oxaliplatin-induced neuropathic pain in rats
    Nobuaki Egashira
    Department of Pharmacy, Kyushu University Hospital, Japan
    J Pharmacol Sci 112:473-6. 2010
    ..b>Mexiletine, an orally available Na(+)-channel blocker, has widely been used in patients with chronic painful diabetic ..
  28. pmc Experience with oral mexiletine in primary erythromelalgia in children
    Javeed Iqbal
    Department of Pediatrics and Neonatology, Sher I Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir 190019, India
    Ann Saudi Med 29:316-8. 2009
    ..Both patients stopped taking part in school and social activities. We tried oral mexiletine, a class Ib antiarrythmic agent, in view of its reported role in various chronic painful conditions...
  29. ncbi The effect of intravenous lidocaine, tocainide, and mexiletine on spontaneously active fibers originating in rat sciatic neuromas
    C Chabal
    Department of Anesthesiology, University of Washington School of Medicine, Seattle
    Pain 38:333-8. 1989
    The effects of intravenously administered subanesthetic concentrations of lidocaine, tocainide, and mexiletine on spontaneously active fibers (SAFs) originating in 7-day-old rat sciatic neuromas were studied...
  30. ncbi The analgesic effect of gabapentin and mexiletine after breast surgery for cancer
    Argyro Fassoulaki
    Department of Anesthesiology, Aretaieion Hospital, Medical School, University of Athens, Greece
    Anesth Analg 95:985-91, table of contents. 2002
    We investigated the analgesic efficacy of mexiletine and gabapentin on acute and chronic pain associated with cancer breast surgery in 75 patients...
  31. pmc Mexiletine block of disease-associated mutations in S6 segments of the human skeletal muscle Na(+) channel
    M P Takahashi
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Physiol 537:701-14. 2001
    ..We examined state-dependent mexiletine block for mutations involving the putative binding site in S6 segments (V445M, S804F, V1293I, V1589M and M1592V)...
  32. ncbi Validated HPTLC methods for quantification of mexiletine hydrochloride in a pharmaceutical formulation
    Rafal Pietraś
    Medical University of Lublin, Department of Medicinal Chemistry, Jaczewskiego 4, 20 090 Lublin, Poland
    J AOAC Int 93:820-4. 2010
    Two simple, accurate, and precise HPTLC methods have been established for the determination of mexiletine hydrochloride, an antiarrhythmic agent, in Mexicord capsules...
  33. ncbi Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment
    Kazuaki Kanai
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Brain 126:965-73. 2003
    ..threshold electrotonus, refractoriness and supernormality] using threshold tracking and the effects of mexiletine hydrochloride on those cramps...
  34. pmc Analgesic activity of a novel use-dependent sodium channel blocker, crobenetine, in mono-arthritic rats
    J M Laird
    Department of Physiology, University of Alcala, Alcala de Henares, E 28871 Madrid, Spain
    Br J Pharmacol 134:1742-8. 2001
    ..The clinically effective sodium channel blocker, mexiletine, was compared with crobenetine (BIII 890 CL), a new, highly use-dependent sodium channel blocker. 2...
  35. ncbi Gating properties of SCN5A mutations and the response to mexiletine in long-QT syndrome type 3 patients
    Yanfei Ruan
    Molecular Cardiology, Fondazione Salvatore Maugeri, Via Maugeri 10 10A, 27100 Pavia, Italy
    Circulation 116:1137-44. 2007
    b>Mexiletine (Mex) has been proposed as a gene-specific therapy for patients with long-QT syndrome type 3 (LQT3) caused by mutations in the cardiac sodium channel gene (SCN5A)...
  36. ncbi Drug-induced hypersensitivity syndrome due to mexiletine associated with human herpes virus 6 and cytomegalovirus reactivation
    Atsushi Sekiguchi
    Department of Dermatology, Asahikawa Medical College, Asahikawa 078 8510, Japan
    J Dermatol 32:278-81. 2005
    A 66-year-old man developed a fever of 38 degrees C and generalized pruritic rash about one month after mexiletine hydrochloride administration for ventricular tachycardia...
  37. ncbi Primary erythromelalgia in a child responding to intravenous lidocaine and oral mexiletine treatment
    Aruna Nathan
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatrics 115:e504-7. 2005
    ..However, intravenous lidocaine infusion, with subsequent transition to oral mexiletine therapy, proved very effective in reducing the frequency and severity of the pain episodes...
  38. ncbi Preferred mexiletine block of human sodium channels with IVS4 mutations and its pH-dependence
    Bahram Mohammadi
    Department of Neurology, Medical School Hannover, Hannover, Germany
    Pharmacogenet Genomics 15:235-44. 2005
    The effects of extracellular pH (6.2, 7.4 and 8.2) and 0.1 mM mexiletine, a channel blocker of the lidocaine type, are studied on two mutations of the fourth voltage sensor of the Nav1.4 sodium channel, R1448H/C...
  39. doi Suppression of atrial fibrillation with mexiletine pharmacotherapy in a young woman with type 1 long QT syndrome
    Malek El Yaman
    Department of Pediatrics Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN 55905, USA
    Heart Rhythm 5:472-4. 2008
  40. ncbi Mexiletine-induced severe skin eruption, fever, eosinophilia, atypical lymphocytosis, and liver dysfunction
    K Higa
    Department of Anesthesiology, School of Medicine, Fukuoka University, Japan
    Pain 73:97-9. 1997
    ..skin eruption, fever, eosinophilia, atypical lymphocytosis, and liver dysfunction 30 days after ingestion of mexiletine, a sodium channel blocker, prescribed to treat postherpetic neuralgia...
  41. ncbi A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine
    Carmen R Valdivia
    Departments of Medicine and Physiology, University of Wisconsin, Madison, WI, USA
    Cardiovasc Res 55:279-89. 2002
    ..Mutations in the cardiac sodium channel gene, SCN5A, cause congenital long QT syndrome (LQT3), Brugada syndrome, idiopathic ventricular fibrillation, and conduction disease by distinct cellular and clinical electrophysiological phenotypes...
  42. ncbi Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers
    A De Luca
    Unità di Farmacologia, Dipartimento Farmacobiologico, Bari, Italy
    Naunyn Schmiedebergs Arch Pharmacol 352:653-61. 1995
    The effects of the enantiomers of mexiletine were tested on sodium currents of frog skeletal muscle fibers recorded by means of the three vaseline gap voltage clamp method and compared with the effects produced by tocainide enantiomers...
  43. ncbi Translation of flecainide- and mexiletine-induced cardiac sodium channel inhibition and ventricular conduction slowing from nonclinical models to clinical
    B M Heath
    Department of Safety Pharmacology, GlaxoSmithKline, Park Road, Ware, SG12 0DP, UK
    J Pharmacol Toxicol Methods 63:258-68. 2011
    ..sodium channel block, and translation of the effect from in vitro to in vivo models using sodium channel inhibitors flecainide and mexiletine; flecainide, but not mexiletine is commonly associated with QRS complex prolongation in humans.
  44. ncbi Effect of sodium channel blocker (mexiletine) on pathological ectopic firing pattern in a rat chronic constriction nerve injury model
    Satoru Nakamura
    Department of Orthopedic Surgery, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa, 078 8510, Japan
    J Orthop Sci 10:315-20. 2005
    We studied the efficacy of mexiletine as a sodium channel blocker for neuropathic pain by investigating the effect of mexiletine on the pathological ectopic firing pattern in a chronic constriction nerve injury (CCI) model...
  45. ncbi Deracemization of mexiletine biocatalyzed by omega-transaminases
    Dominik Koszelewski
    Department of Chemistry, Organic and Bioorganic Chemistry, Research Centre Applied Biocatalysis, University of Graz, Heinrichstrasse 28, A 8010 Graz, Austria
    Org Lett 11:4810-2. 2009
    S)- as well as (R)-mexiletine [1-(2,6-dimethylphenoxy)-2-propanamine], a chiral orally effective antiarrhythmic agent, was prepared by deracemization starting from the commercially available racemic amine using omega-transaminases in up ..
  46. ncbi Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity
    Alessia Catalano
    Department of Medicinal Chemistry, University of Bari, Bari, Italy
    Arch Pharm (Weinheim) 343:325-32. 2010
    ..1 and 4-(2-aminopropoxy)-3-(hydroxymethyl)-5-methylphenol 2, two dihydroxylated analogs of mexiletine - a well known class IB anti-arrhythmic drug - were synthesized and used as pharmacological tools to investigate ..
  47. ncbi Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile
    Annamaria De Luca
    Sezione di Farmacologia, Dipartimento Farmacobiologico, Facolta di Farmacia, Universita di Bari, Campus, Via Orabona 4, 70125 Bari, Italy
    Naunyn Schmiedebergs Arch Pharmacol 367:318-27. 2003
    In striated fibers, the activity of mexiletine (Mex)-like sodium channel blockers is strongly modulated by the part of the molecule nearby the asymmetric carbon atom...
  48. ncbi Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice
    Larissa Fabritz
    Department of Cardiology and Angiology, University Hospital Munster, Munster, Germany
    Cardiovasc Res 57:1085-93. 2003
    It has been suggested that both pacing and treatment with mexiletine may reduce torsade de pointes (TdP) arrhythmias in patients with long QT syndrome 3 (LQT3), but it is not fully understood how these interventions could prevent TdP...
  49. ncbi Effect of oral mexiletine on capsaicin-induced allodynia and hyperalgesia: a double-blind, placebo-controlled, crossover study
    K Ando
    Department of Anesthesiology, University of California, San Diego, La Jolla 92093-0924, USA
    Reg Anesth Pain Med 25:468-74. 2000
    BACKGROUND AND OBJECTIVES: Mexiletine is a sodium channel blocker that has been used for the treatment of a variety of neuropathic pain syndromes...
  50. ncbi A case of fulminant Type 1 diabetes associated with mexiletine hypersensitivity syndrome
    Y Seino
    Diabet Med 21:1156-7. 2004
  51. ncbi Digoxin and mexiletine sensitivity in a Collie with the MDR1 mutation
    Rosemary A Henik
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, USA
    J Vet Intern Med 20:415-7. 2006
  52. ncbi A case of primary erythromelalgia improved by mexiletine
    H S Jang
    Br J Dermatol 151:708-10. 2004
  53. pmc Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na+ channels
    Ging Kuo Wang
    Department of Anaesthesia, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    J Physiol 554:621-33. 2004
    b>Mexiletine is a class 1b antiarrhythmic drug used for ventricular arrhythmias but is also found to be effective for paramyotonia congenita, potassium-aggravated myotonia, long QT-3 syndrome, and neuropathic pain...
  54. ncbi Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels
    Carlo Franchini
    Dipartimento Farmaco Chimico and Farmaco Biologico, Università degli Studi di Bari Via E Orabona 4, 70125 Bari, Italy
    J Med Chem 46:5238-48. 2003
    Optically active mexiletine analogues were synthesized and evaluated in vitro as use-dependent blockers of skeletal muscle sodium channels...
  55. ncbi Positive symptoms in multiple sclerosis: their treatment with sodium channel blockers, lidocaine and mexiletine
    M Sakurai
    Department of Neurology, Graduate School of Medicine, University of Tokyo, Japan
    J Neurol Sci 162:162-8. 1999
    ..Similar effects were obtained with orally-administered mexiletine (300-400 mg/day), a derivative of lidocaine, but to a lesser extent...
  56. ncbi Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide
    A De Luca
    Dipartimento Farmacobiologico, Facolta di Farmacia, Bari, Italy
    Naunyn Schmiedebergs Arch Pharmacol 356:777-87. 1997
    ..muscle sodium channels as potential antimyotonic agents, the actions of newly synthesized chiral analogs of mexiletine and tocainide were tested in vitro on sodium currents of single fibers of frog semitendinosus muscle by vaseline-..
  57. ncbi A novel spinal action of mexiletine in spinal somatosensory transmission of nerve injured rats
    V Chapman
    Department of Pharmacology, University College London, UK
    Pain 77:289-96. 1998
    b>Mexiletine is widely used for the treatment of neuropathic pain although its site(s) of action remain unclear...
  58. ncbi Design and assessment of a potent sodium channel blocking derivative of mexiletine for minimizing experimental neuropathic pain in several rat models
    Robert M Weston
    Howard Florey Institute, University of Melbourne, Parkville, VIC 3010, Australia
    Neurochem Res 34:1816-23. 2009
    ..We have developed an analogue of mexiletine which is approximately 80 times more potent than mexiletine in competing with the radioligand, 3H-..
  59. ncbi 2D- and 3D-QSAR of tocainide and mexiletine analogues acting as Na(v)1.4 channel blockers
    Antonio Carrieri
    Dipartimento Farmaco Chimico, Universita degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy
    Eur J Med Chem 44:1477-85. 2009
    Enantiomeric forms of Tocainide, Mexiletine, and structurally related local anaesthetic compounds, were analyzed with respect to their potency in blocking Na(v)1.4 channel...
  60. ncbi Systemic lidocaine or mexiletine for neuropathic pain
    Mark H Ebell
    Am Fam Physician 74:79. 2006
  61. ncbi Acute exanthematous pustular drug eruption induced by mexiletine
    K Sasaki
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Eur J Dermatol 11:469-71. 2001
    ..infiltrated erythemas on the trunk, extremities, and face with marked facial edema, one month after taking mexiletine hydrochloride for his arrhythmia...
  62. ncbi Regional block and mexiletine: the effect on pain after cancer breast surgery
    A Fassoulaki
    Department of Anesthesiology, St Savas Hospital, Athens, Greece
    Reg Anesth Pain Med 26:223-8. 2001
    ..The present study investigates the effect of regional block, oral mexiletine, and the combination of both, on acute and chronic pain associated with cancer breast surgery.
  63. ncbi Mexiletine for refractory chronic daily headache: a report of nine cases
    Michael J Marmura
    Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Headache 48:1506-10. 2008
    To describe the use of mexiletine in the treatment of chronic daily headache in a refractory headache population.
  64. ncbi Drug-induced hypersensitivity syndrome due to mexiletine hydrochloride associated with reactivation of human herpesvirus 7
    Akiko Yagami
    Department of Dermatology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan
    Dermatology 213:341-4. 2006
    ..He was diagnosed with DIHS due to mexiletine hydrochloride based on laboratory data, results of a patch test and the clinical course of his complaint, and ..
  65. ncbi Mexiletine protects myocardium during acute ischemia by opening sarcolemmal K-ATP channel: studies in closed-chest acute ischemia model in rabbits
    Shinichi Niwano
    Department of Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan
    J Cardiovasc Pharmacol 44:639-44. 2004
    Although we have previously shown that mexiletine might protect myocardium during acute ischemia, the precise mechanism was unclear...
  66. ncbi A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor
    Suk Ying Tsang
    The Johns Hopkins University, 720 Rutland Avenue, Ross 1165, Baltimore MD 21205, USA
    Mol Pharmacol 67:424-34. 2005
    ..g., 300 microM mexiletine induced a use-dependent block with 65.0 +/- 2.9% remaining current and -11.0 +/- 0...
  67. pmc Mexiletine therapy for chronic pain: survival analysis identifies factors predicting clinical success
    Ian R Carroll
    Stanford Pain Management Center, Stanford University Medical Center, Palo Alto, CA 94304 1573, USA
    J Pain Symptom Manage 35:321-6. 2008
    b>Mexiletine, a sodium channel blocker, treats neuropathic pain but its clinical value has been questioned due to its significant side effects and limited efficacy...
  68. ncbi The effects of Na movement on surgical myocardial protection: the role of the Na+-H+ exchange system and Na-channel in the development of ischemia and reperfusion injury
    Ke Xiang Liu
    Department of Cardiovascular Surgery, The Second Clinical Hospital, Jilin University, Changchun, China
    Ann Thorac Cardiovasc Surg 13:301-7. 2007
    We investigated whether the Na+-H+ exchange inhibitor, HOE642 (Hoe), and/or the Na channel blocker, mexiletine (Mex), enhance a cardioprotective effect on St...
  69. ncbi Rate-dependent QRS prolongation during exercise testing associated with hyperkalemia
    Hirokazu Shiraishi
    Kyoto Perfectual University of Medicine, Kyoto, Japan
    J Electrocardiol 37:241-5. 2004
    ..The increase of QRS duration was possibly due to the combination of hyperkalemia and the effect of mexiletine. The rate dependent blocking effect on sodium channel of mexiletine might be intensified under hyperkalemia.
  70. ncbi Differential contribution of sodium channel subtypes to action potential generation in unmyelinated human C-type nerve fibers
    Philip M Lang
    Department of Anesthesiology, University of Munich, Munich, Germany
    Anesthesiology 107:495-501. 2007
    ..The aim of the current study was to characterize subtypes of Na(v) that contribute to action potential generation in peripheral unmyelinated human C-type nerve fibers...
  71. ncbi Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access
    Koji Sasaki
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Mol Pharmacol 66:330-6. 2004
    ..next to the putative selectivity filter residue of domain 4, and evaluated the pharmacological properties to mexiletine using whole-cell, patch-clamp recordings...
  72. ncbi Characterization of mexiletine as an antagonist of beta-adrenoceptor in Chinese hamster ovary cells expressing cloned human beta-adrenoceptors
    Kenji Sakamoto
    Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 9 1 Shirokane 5 chome, Minato ku, Tokyo 108 8641, Japan
    Biochem Pharmacol 67:815-22. 2004
    We characterized the beta-adrenoceptor-blocking property of mexiletine, a class Ib antiarrhythmic drug, on Chinese hamster ovary (CHO) cells stably expressing cloned human beta1-, beta2-, and beta3-adrenoceptors...
  73. ncbi The effects of mexiletine on excitability properties of human median motor axons
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Clin Neurophysiol 116:284-9. 2005
    To investigate the effects of mexiletine, an analog of lidocaine, on excitability of human axons in vivo.
  74. ncbi [The filter region of the myocardial Na channel, together with ion selectivity, controls pharmacodynamics of anti-arrhythmia agents--an analysis using the channel altered by idiopathic ventricular fibrillation]
    Koji Sasaki
    Hokkaido Igaku Zasshi 79:747-54. 2004
  75. ncbi Acetazolamide acts directly on the human skeletal muscle chloride channel
    Hiroto Eguchi
    First Department of Internal Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Muscle Nerve 34:292-7. 2006
    ....
  76. ncbi Successful parental use of an automated external defibrillator for an infant with long-QT syndrome
    Abhay Divekar
    Section of Pediatric Cardiology, Department of Pediatrics, Health Sciences Center, University of Manitoba, FE 241, 685 William Ave, Winnipeg, Manitoba, Canada R3E 0Z2
    Pediatrics 118:e526-9. 2006
    ..In this case report we describe the first successful parental use of an automated external defibrillator prescribed for primary prophylaxis against sudden cardiac death in an infant with long-QT syndrome...
  77. ncbi Class Ic antiarrhythmics block human skeletal muscle Na channel during myotonia-like stimulation
    Futoshi Aoike
    Department of Neurology, Osaka University Graduate School of Medicine D 4, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Eur J Pharmacol 532:24-31. 2006
    ..In contrast to mexiletine, flecainide did not markedly block sodium current during prolonged depolarization, suggesting an open-channel ..
  78. pmc A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y
    Leigh D Plant
    Department of Pediatrics and Institute for Molecular Pediatric Sciences, Pritzker School of Medicine, Biological Sciences Division, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 116:430-5. 2006
    ..Only Y1103 channels gained abnormal function, demonstrating late reopenings suppressible by the drug mexiletine. The variant appeared to confer susceptibility to acidosis-induced arrhythmia, a gene-environment interaction...
  79. ncbi Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice
    Catherine E Head
    Physiological Laboratory, University of Cambridge, Downing Street, Cambridge, UK
    J Cardiovasc Electrophysiol 16:1329-40. 2005
    ....
  80. ncbi The cutaneous analgesic effect of class I antiarrhythmic drugs
    Jann Inn Tzeng
    Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan
    Anesth Analg 104:955-8. 2007
    ..Because all Class I antiarrhythmic drugs are Na+ channel blockers, theoretically, they may have local anesthetic effects. In this study, we sought to define the cutaneous local anesthetic actions of three Class I antiarrhythmic drugs...
  81. ncbi Comparison of the effects of four Na+ channel analgesics on TTX-resistant Na+ currents in rat sensory neurons and recombinant Nav1.2 channels
    Thomas Weiser
    Department CNS Research, Boehringer Ingelheim Pharma GmbH and Co KG, D 88397 Biberach, Germany
    Neurosci Lett 395:179-84. 2006
    ..2 alpha subunits. The compounds were lidocaine, mexiletine, benzocaine, and ambroxol, which are clinically used to treat pain after local or systemic administration...
  82. ncbi The effect of intravenously administered mexiletine on tinnitus - a pilot study
    Erik Berninger
    Department of Audiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Int J Audiol 45:689-96. 2006
    The effect of intravenously administered mexiletine on subjective tinnitus and hearing was studied in six patients, who initially responded positively to lidocaine...
  83. ncbi Molecular basis for exaggerated sensitivity to mexiletine in the cardiac isoform of the fast Na channel
    Hiroyuki Kawagoe
    Department of Physiology, School of Medicine, Hiroshima University, Kasumi 1 2 3, Minami Ku, 734 8551, Hiroshima, Japan
    FEBS Lett 513:235-41. 2002
    ..To examine if this is also true for mexiletine, we have systematically measured mexiletine sensitivity of the Na channel isoforms, rH1, (mu)1, and rBII, which ..
  84. ncbi Analysis of human Nav1.8 expressed in SH-SY5Y neuroblastoma cells
    Lodewijk V Dekker
    Ionix Pharmaceuticals Ltd, 418 Cambridge Science Park, Cambridge CB4 0PA UK
    Eur J Pharmacol 528:52-8. 2005
    ..8 were inhibited by the sodium channel blockers BIII 890 CL, NW-1029, and mexiletine. Inhibition of Nav1.8 by these compounds may underlie their known analgesic effects in animal models.
  85. ncbi A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents
    Mossaab Shuraih
    Electrophysiology Research Laboratory, Texas Heart Institute St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    J Cardiovasc Electrophysiol 18:434-40. 2007
    ..However, little is known about the impact of those polymorphisms on the pharmocological response of hNav1.5 to various antiarrhythmic agents...
  86. ncbi Inhibitory effects of lidocaine and mexiletine on vasorelaxation mediated by adenosine triphosphate-sensitive K+ channels and the role of kinases in the porcine coronary artery
    Yoshiki Kimoto
    Department of Anesthesiology, Wakayama Medical University, Wakayama, Japan
    Anesthesiology 102:581-7. 2005
    ..The current study examined whether lidocaine and mexiletine in the porcine coronary artery modify the vasorelaxation mediated by adenosine triphosphate-sensitive K channels ..
  87. ncbi Inactivation-deficient human skeletal muscle Na+ channels (hNav1.4-L443C/A444W) in stably transfected HEK-293 cells
    S Y Wang
    Department of Biology, State University of New York at Albany, Albany, NY, USA
    Receptors Channels 10:131-8. 2004
    ..Persistent late Na+currents were far more sensitive to block by class 1 anti-arrhythmic flecainide, mexiletine, propafenone, and amiodarone at 10 microM than peak Na+currents...
  88. ncbi [Clinical applications and the effect of mexiletine on refractory epilepsies]
    H Enoki
    Department of Child Neurology, Okayama University Medical School
    No To Hattatsu 32:29-34. 2000
    Twenty-four patients with refractory epilepsy were treated with mexiletine as an additional antiepileptic drug. As the initial responses, seizures were decreased by 50% or more in 7 (46...
  89. ncbi The sodium channel blocker RS100642 reverses down-regulation of the sodium channel alpha-subunit Na(v) 1.1 expression caused by transient ischemic brain injury in rats
    C Yao
    Division of Neurosciences, Walter Reed Army Institute of Research, 503 Robert Grant Ave Rm 2W14, Silver Spring, MD 20910 7500, USA
    Neurotox Res 5:245-53. 2003
    ..with the NaCh blocker and experimental neuroprotective agent RS100642 as compared to the prototype NaCh blocker mexiletine. The expression of Na(v) 1.1, Na(v) 1.2, Na(v) 1.3, Na(v) 1.7, Na(v) 1...
  90. ncbi Ventricular tachyarrhythmias in a canine model of LQT3: arrhythmogenic effects of sympathetic activity and therapeutic effects of mexiletine
    Masaomi Chinushi
    School of Health Science, Niigata University School of Medicine, Japan
    Circ J 67:263-8. 2003
    ..The VSP was performed 8 times before and 5 times after administration of mexiletine in each experiment...
  91. ncbi Mexiletine differentially modulates vasorelaxation mediated by adenosine triphosphate-sensitive K+ channels in aortas from normotensive and hypertensive rats
    Yoshiki Kimoto
    Department of Anesthesiology, Wakayama Medical College, Japan
    Anesth Analg 96:673-9, table of contents. 2003
    ..We designed the present study to examine whether mexiletine modulates vasorelaxation via these channels in hypertensive rat aortas...
  92. ncbi A molecular basis for the therapy of the long QT syndrome
    S G Priori
    Dipartimento di Cardiologia, Facolta di Medicina e Chirurgla, , Policlinico San Matteo IRCCS, Italy
    Arch Mal Coeur Vaiss 89:1185-7. 1996
    ..Results showed that 1) mexiletine shortened significantly the QT interval among LQT3 patients but not among LQT2 patients and 2) LQT3 patients ..
  93. ncbi Storms of ventricular tachyarrhythmias associated with primary hyperparathyroidism in a patient with dilated cardiomyopathy
    Christof Kolb
    Int J Cardiol 87:115-6. 2003
  94. ncbi [Differential diagnosis of idiopathic ventricular fibrillation]
    A Buob
    Medizinische Universitätsklinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Dtsch Med Wochenschr 127:2517-23. 2002
  95. ncbi Effects of disopyramide and mexiletine on the terminal repolarization process of the in situ heart assessed using the halothane-anesthetized in vivo canine model
    Hiroshi Yoshida
    Department of Pharmacology, Yamanashi Medical University, Nakakoma gun, Japan
    Circ J 66:857-62. 2002
    ..Disopyramide (0.3 and 3.0 mg/kg per 10 min, n = 6) or mexiletine (0.3 and 3...
  96. ncbi Activation-recovery interval as a parameter to assess the intracardiac ventricular repolarization in patients with congenital long QT syndrome
    Masaomi Chinushi
    School of Health Science, Niigata, Japan
    Am J Cardiol 90:432-5. 2002
  97. ncbi Pharmacological rescue of mutant ion channels
    Connie R Bezzina
    Cardiovasc Res 55:229-32. 2002
  98. ncbi Possible mechanism for pharmacokinetic interaction between lidocaine and mexiletine
    Yorinobu Maeda
    Department of Pharmacy, Chugoku Rousai Hospital, 1 5 1 Hiro Tagaya, Kure City, Hiroshima 737 0193, Japan
    Clin Pharmacol Ther 71:389-97. 2002
    Our objective was to elucidate the mechanism of pharmacokinetic interaction between lidocaine and mexiletine, because an unexpected increase in plasma lidocaine concentration accompanied by severe side effects was observed when mexiletine ..
  99. ncbi DDPH inhibited L-type calcium current and sodium current in single ventricular myocyte of guinea pig
    X D Hu
    Department of Pharmacology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China
    Acta Pharmacol Sin 22:415-9. 2001
    ..L-type calcium current (ICa) and sodium current (INa), and to compare its inhibitory potency with verapamil and mexiletine. METHODS: Whole-cell patch clamp technique was used to record ICa and INa in a single ventricular myocytes of ..
  100. ncbi Sodium channel blocking actions of the kappa-opioid receptor agonist U50,488 contribute to its visceral antinociceptive effects
    X Su
    Department of Pharmacology, College of Medicine, The University of Iowa, Bowen Science Building, Iowa City, IA 52242, USA
    J Neurophysiol 87:1271-9. 2002
    ..The mean inhibitory doses of these drugs were not different (range: 6.6-10.8 mg/kg). Sodium channel blockers mexiletine and carbamazepine mimicked the effect of U50,488...
  101. ncbi Alteration of ischemic reperfusion injury in the rat neocortex by a potent antioxidant mexiletine
    C Z Chang
    Department of Neurosurgery, Kaohsiung Medical University Hospital, No 100, Shih Chuan 1st Road, Kaohsiung, Taiwan, Repiblic of China
    Acta Neurochir (Wien) 144:189-93; discussion 193. 2002
    The mechanisms by which mexiletine exerts its effects in increasing myocardial circulation, and smooth muscle perfusion and alleviating diabetic neuropathic pain have been widely discussed...

Research Grants19

  1. Phase II Therapeutic Trial of Mexiletine
    Richard J Barohn; Fiscal Year: 2010
    ..Most cases of NDM are related to mutations in voltage-dependent sodium or chloride channels. Mexiletine is a class 1B antiarrhythmic medication that has high affinity for muscle sodium channels...
  2. Local anesthetic receptor in peripheral Na+ channels
    GING K WANG; Fiscal Year: 2013
    ..amitriptyline and duloxetine, antiarrhymthic flecainide, antianginal ranolazine, and anticonvulsant mexiletine, all preferentially block persistent late Na+ currents via the LA receptor...
  3. Phase 2 Study of Mexiletine for the Treatment of Myotonic Dystrophy
    Richard T Moxley; Fiscal Year: 2013
    ..Two recent, short-term, FDA funded, 7 week double-blind, placebo-controlled, crossover trials of mexiletine (150 mg TID vs. placebo TID;200mg TID vs. placebo TID) have been performed in our Neuromuscular Disease Center...
  4. MASS SPECTROMETER SYSTEM AND ACCESSORIES
    ALAN NIES; Fiscal Year: 1990
    ..This proposal is to develop GC/MS methodology for the analysis of mexiletine enantiomers in serum in order to determine the stereochemical aspects of disposition when mexiletine (a racemic ..
  5. RANDOMIZED AMIODARONE THERAPY FOR SURVIVORS OF VF
    Leon Greene; Fiscal Year: 1991
    ..whether treatment with amiodarone and conventional antiarrhythmic agents (quinidine, procainamide, disopyramide, mexiletine, flecainide or tocainide) yields equivalent survival, equal suppression of ambient ventricular arrhythmias, ..
  6. PAIN MANAGEMENT IN PERSONS WITH DISABILITIES
    Barbara de Lateur; Fiscal Year: 2000
    ..will use a double-blind, placebo-controlled, cross-over study to assess the efficacy of long acting opioids and mexiletine to ameliorate pain and improve function in persons with phantom limb pain...
  7. THERAPUTIC TRIAL IN PATIENTS WITH LQTS 3 GENE MUTATION
    Arthur Moss; Fiscal Year: 2002
    ..aims of this study of LQT3 patients are to determine: 1) if a low dose of the oral sodium-channel blocking drug mexiletine significantly shortens QTc by greater than or equal to 40 msec; and 2) if chronic administration of mexiletine ..
  8. STEROSPECIFIC ANALYSIS OF NEW ANTIARRHYTHMIC AGENTS
    Joseph Gal; Fiscal Year: 1990
    ..The search for new and better antiarrhythmic drugs has produced several promising agents, including mexiletine, flecainide and propafenone...
  9. NEUROLOGIC AIDS RESEARCH CONSORTIUM
    David Clifford; Fiscal Year: 2001
    ..performance as a measure of disease progression, (3) A double-blind controlled study of amitriptyline and mexiletine in the treatment of HIV associated painful peripheral neuropathy, (4) A controlled clinical trial testing the ..
  10. REGULATION OF LATE INWARD CURRENT IN HUMAN HEART FAILURE
    Jonathan Makielski; Fiscal Year: 2003
    ....
  11. THERAPEUTIC NA+ CHANNEL BLOCKERS: RECEPTOR & DRUG DESIGN
    GING WANG; Fiscal Year: 2007
    ..screening demonstrated that drugs taken orally for neuropathic pain, such as amitriptyline, flecainide, and mexiletine, also block open Na+ channels effectively at their therapeutic plasma concentrations...
  12. MOLECULAR BASIS OF LIGAND/SODIUM CHANNEL INTERACTIONS
    GING WANG; Fiscal Year: 2002
    ....
  13. Cellular Mechanisms of Hyperalgesia and Opioid Tolerance
    Jianren Mao; Fiscal Year: 2005
    ....
  14. CHARGED DIHYDROPYRIDINES--PROBES OF HEART CA++ CHANNELS
    Robert Kass; Fiscal Year: 2001
    ....
  15. PHARMACOLOGY OF CARDIAC SODIUM CHANNEL MODIFIERS
    Michael Sheets; Fiscal Year: 2008
    ..The results of these studies should improve our overall understanding of the molecular mechanisms of anti-arrhythmic drugs modification of cardiac Na channels. [unreadable] [unreadable]..
  16. OPIOID-INDUCED PAIN SENSITIVITY: CLINICAL DIAGNOSIS AND MANAGEMENT
    Jianren Mao; Fiscal Year: 2010
    ....
  17. Glutamate Uptake & the Pathogenesis of Neuropathic Pain
    Jianren Mao; Fiscal Year: 2007
    ..abstract_text> ..
  18. Neuropathic Pain Modulation by Cannabinoids
    Jianren Mao; Fiscal Year: 2006
    ..A better understanding of cannabinoid actions in neuropathic pain states could open a new avenue to developing novel pharmacological tools for the improved management of often intractable and debilitating neuropathic pain syndromes. ..