Summary: The active sympathomimetic hormone from the adrenal medulla in most species. It stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. It is used in asthma and cardiac failure and to delay absorption of local anesthetics.

Top Publications

  1. ncbi Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium
    Hugh A Sampson
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 117:391-7. 2006
  2. ncbi Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest
    Akihito Hagihara
    Kyushu University Graduate School of Medicine, Department of Health Services Management and Policy, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    JAMA 307:1161-8. 2012
  3. ncbi Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes
    P E Cryer
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetologia 45:937-48. 2002
  4. ncbi Epinephrine-mediated regulation of PDK4 mRNA in rat adipose tissue
    Zhongxiao Wan
    Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Cell Physiol 299:C1162-70. 2010
  5. ncbi Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-alphavbeta3 interactions
    Rahima Zennadi
    Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Blood 104:3774-81. 2004
  6. pmc Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo
    Rahima Zennadi
    Division of Hematology and Duke Comprehensive Sickle Cell Center, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Blood 110:2708-17. 2007
  7. pmc Bacteria-host communication: the language of hormones
    Vanessa Sperandio
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    Proc Natl Acad Sci U S A 100:8951-6. 2003
  8. pmc The QseC sensor kinase: a bacterial adrenergic receptor
    Marcie B Clarke
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    Proc Natl Acad Sci U S A 103:10420-5. 2006
  9. ncbi Epinephrine: a short- and long-term regulator of stress and development of illness : a potential new role for epinephrine in stress
    Dona Lee Wong
    Department of Psychiatry, Harvard Medical School, MA, USA
    Cell Mol Neurobiol 32:737-48. 2012
  10. ncbi Epinephrine increases DNA synthesis via ERK1/2s through cAMP, Ca(2+)/PKC, and PI3K/Akt signaling pathways in mouse embryonic stem cells
    Mi Ok Kim
    Department of Veterinary Physiology, Biotherapy Human Resources Center BK 21, College of Veterinary Medicine, Chonnam National University, Gwangju 500 757, Korea
    J Cell Biochem 104:1407-20. 2008

Detail Information

Publications373 found, 100 shown here

  1. ncbi Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium
    Hugh A Sampson
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 117:391-7. 2006
  2. ncbi Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest
    Akihito Hagihara
    Kyushu University Graduate School of Medicine, Department of Health Services Management and Policy, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    JAMA 307:1161-8. 2012
    b>Epinephrine is widely used in cardiopulmonary resuscitation for out-of-hospital cardiac arrest (OHCA). However, the effectiveness of epinephrine use before hospital arrival has not been established.
  3. ncbi Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes
    P E Cryer
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetologia 45:937-48. 2002
    ..Insulin concentrations do not decrease and glucagon and epinephrine concentrations do not increase normally as glucose concentrations decrease...
  4. ncbi Epinephrine-mediated regulation of PDK4 mRNA in rat adipose tissue
    Zhongxiao Wan
    Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Cell Physiol 299:C1162-70. 2010
    ..In this regard we hypothesized that exercise, fasting, and epinephrine would increase PDK4 mRNA levels in rat epididymal adipose tissue...
  5. ncbi Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-alphavbeta3 interactions
    Rahima Zennadi
    Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Blood 104:3774-81. 2004
    ..that up-regulation of intracellular cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) by epinephrine significantly increased sickle but not normal erythrocyte adhesion to both primary and immortalized ECs...
  6. pmc Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo
    Rahima Zennadi
    Division of Hematology and Duke Comprehensive Sickle Cell Center, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Blood 110:2708-17. 2007
    ..We previously found that the LW RBC adhesion receptor can be activated by epinephrine to mediate SS RBC adhesion to endothelial alphavbeta3 integrin...
  7. pmc Bacteria-host communication: the language of hormones
    Vanessa Sperandio
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    Proc Natl Acad Sci U S A 100:8951-6. 2003
    ..We have identified this signal as the hormone epinephrine and show that beta- and alpha-adrenergic antagonists can block the bacterial response to this hormone...
  8. pmc The QseC sensor kinase: a bacterial adrenergic receptor
    Marcie B Clarke
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    Proc Natl Acad Sci U S A 103:10420-5. 2006
    ..The AI-3 quorum-sensing system is also involved in interkingdom signaling with the eukaryotic hormones epinephrine/norepinephrine...
  9. ncbi Epinephrine: a short- and long-term regulator of stress and development of illness : a potential new role for epinephrine in stress
    Dona Lee Wong
    Department of Psychiatry, Harvard Medical School, MA, USA
    Cell Mol Neurobiol 32:737-48. 2012
    b>Epinephrine (Epi), which initiates short-term responses to cope with stress, is, in part, stress-regulated via genetic control of its biosynthetic enzyme, phenylethanolamine N-methyltransferase (PNMT)...
  10. ncbi Epinephrine increases DNA synthesis via ERK1/2s through cAMP, Ca(2+)/PKC, and PI3K/Akt signaling pathways in mouse embryonic stem cells
    Mi Ok Kim
    Department of Veterinary Physiology, Biotherapy Human Resources Center BK 21, College of Veterinary Medicine, Chonnam National University, Gwangju 500 757, Korea
    J Cell Biochem 104:1407-20. 2008
    b>Epinephrine is a catecholamine that plays important roles in regulating a wide variety of physiological systems by acting through the adrenergic receptors (ARs)...
  11. ncbi Local infiltration analgesia: a technique for the control of acute postoperative pain following knee and hip surgery: a case study of 325 patients
    Dennis R Kerr
    Joint Orthopaedic Centre, New South Wales, Australia
    Acta Orthop 79:174-83. 2008
    ..The technique allows virtually immediate mobilization and earlier discharge from hospital...
  12. pmc Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter gamma-aminobutyric acid
    Hussein A N Al-Wadei
    Department of Pathobiology, Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Carcinogenesis 30:506-11. 2009
  13. ncbi Dupuytren's fasciectomies in 60 consecutive digits using lidocaine with epinephrine and no tourniquet
    Keith Denkler
    Department of Plastic Surgery, University of California, San Francisco, San Francisco, Calif, USA
    Plast Reconstr Surg 115:802-10. 2005
    ..If local anesthetics are used, they are used without epinephrine, and an arm or forearm tourniquet is essential...
  14. ncbi Initial urinary epinephrine and cortisol levels predict acute PTSD symptoms in child trauma victims
    Douglas L Delahanty
    Department of Psychology, Kent State University, 118 Kent Hall, Kent, OH 44242, USA
    Psychoneuroendocrinology 30:121-8. 2005
    ..The present study extended these findings by examining whether urinary hormone levels collected soon after a trauma were related to subsequent acute PTSD symptoms in child trauma victims...
  15. ncbi Comparison of hemostatic efficacy for epinephrine injection alone and injection combined with hemoclip therapy in treating high-risk bleeding ulcers
    Ching Chu Lo
    Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital and National Yang Ming University, Kaohsiung, Taiwan
    Gastrointest Endosc 63:767-73. 2006
    Rebleeding occurs in 10% to 30% of bleeding ulcer patients receiving endoscopic epinephrine injection therapy...
  16. ncbi Epinephrine and dexamethasone in children with bronchiolitis
    Amy C Plint
    Department of Pediatrics, University of Ottawa and Children s Hospital of Eastern Ontario, Ottawa, Canada
    N Engl J Med 360:2079-89. 2009
    Although numerous studies have explored the benefit of using nebulized epinephrine or corticosteroids alone to treat infants with bronchiolitis, the effectiveness of combining these medications is not well established.
  17. ncbi High levels of circulating epinephrine trigger apical cardiodepression in a β2-adrenergic receptor/Gi-dependent manner: a new model of Takotsubo cardiomyopathy
    Helen Paur
    Myocardial Function Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Circulation 126:697-706. 2012
    ..precipitated by extreme stress and can be triggered by intravenous catecholamine administration, particularly epinephrine. Despite its grave presentation, Takotsubo cardiomyopathy is rapidly reversible, with generally good prognosis...
  18. pmc Improving epinephrine responses in hypoglycemia unawareness with real-time continuous glucose monitoring in adolescents with type 1 diabetes
    Trang T Ly
    Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, Western Australia, Australia
    Diabetes Care 34:50-2. 2011
  19. ncbi The management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunology
    A Muraro
    Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Pediatrics, University of Padua, Padua, Italy
    Allergy 62:857-71. 2007
    ..The creation of national and European databases is expected to generate better-quality data and help develop a stepwise approach for a better management of paediatric anaphylaxis...
  20. pmc Contribution of the sympathetic hormone epinephrine to the sensitizing effect of ethanol on LPS-induced liver damage in mice
    Claudia von Montfort
    Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1227-34. 2008
    ..of the liver, and this effect of ethanol on liver is mediated, at least in part, by the sympathetic hormone, epinephrine. However, whether or not the sympathetic nervous system also contributes to the sensitizing effect of ethanol ..
  21. pmc Stress-induced redistribution of immune cells--from barracks to boulevards to battlefields: a tale of three hormones--Curt Richter Award winner
    Firdaus S Dhabhar
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5135, USA
    Psychoneuroendocrinology 37:1345-68. 2012
    ..2) Individual and combined actions of the principal stress hormones, norepinephrine (NE), epinephrine (EPI), and corticosterone (CORT), in mediating mobilization or trafficking of specific leukocyte subpopulations...
  22. pmc Greater systemic lipolysis in women compared with men during moderate-dose infusion of epinephrine and/or norepinephrine
    Tracy J Horton
    Section of Nutrition, Dept of Pediatrics, Univ of Colorado Denver, Campus Box C225, 12700 East 19th Ave, Aurora, CO 80045, USA
    J Appl Physiol (1985) 107:200-10. 2009
    ..women (n = 11) and men (n = 10) were recruited and studied on 3 separate days with the following infusions: epinephrine (Epi), norepinephrine (NE), or the two combined...
  23. ncbi Comparison of the degree of pulpal anesthesia achieved with the intraosseous injection and infiltration injection using 2% lidocaine with 1:100,000 epinephrine
    John Nusstein
    Department of Endodontics, The Ohio State University, Columbus, USA
    Gen Dent 53:50-3. 2005
    ..obtained from an intraosseous injection to an infiltration injection that used 2% lidocaine with 1:100,000 epinephrine. The success rate for the intraosseous injection was 98%; for the infiltration injection, the success rate was ..
  24. pmc Adrenaline in the treatment of anaphylaxis: what is the evidence?
    Andrew P C McLean-Tooke
    Regional Department of Immunology and Allergy, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP
    BMJ 327:1332-5. 2003
  25. ncbi The role of prednisolone and epinephrine on gastric tissue and erythrocyte antioxidant status in adrenalectomized rats
    A Yildirim
    Department of Biochemistry, Ataturk University, Medical Faculty, Erzurum, Turkey
    J Physiol Pharmacol 58:105-16. 2007
    ..As well, the impacts of administration of prednisolone and epinephrine on these systems in adrenalectomized rats were investigated...
  26. ncbi Epinephrine induces PDK4 mRNA expression in adipose tissue from obese, insulin resistant rats
    Zhongxiao Wan
    Department of Agriculture, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
    Obesity (Silver Spring) 20:453-6. 2012
    ..We recently demonstrated that epinephrine increases PDK4 expression through p38 and peroxisome proliferator-activated receptor γ (PPARγ) dependent ..
  27. ncbi Neural plasticity occurs in the adrenal medulla of asthmatic rats
    Jun Tao Feng
    Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
    Chin Med J (Engl) 123:1333-7. 2010
    Airway symptoms in asthma are related to decrease of epinephrine secretion, which may be ascribed to elevated nerve growth factor (NGF) in the organism...
  28. ncbi Label-free optical biosensor for ligand-directed functional selectivity acting on beta(2) adrenoceptor in living cells
    Ye Fang
    Biochemical Technologies, Science and Technology Division, Corning Incorporated, Sullivan Park, Corning, NY 14831, USA
    FEBS Lett 582:558-64. 2008
    ..This study documents multiple ligand-specific states of the beta(2)-adrenoceptor and highlights the power of the biosensor assays for screening pathway-biased ligands...
  29. ncbi Targeted disruption of the beta2 adrenergic receptor gene
    A J Chruscinski
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, California 94305, USA
    J Biol Chem 274:16694-700. 1999
    ..beta2-AR -/- mice become hypertensive during exercise and exhibit a greater hypertensive response to epinephrine compared with wild type mice...
  30. pmc Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia
    T van der Poll
    Cornell University Medical College, Department of Surgery, New York, NY 10021, USA
    J Clin Invest 97:713-9. 1996
    Short-term preexposure of mononuclear cells to epinephrine inhibits LPS-induced production of TNF, whereas preexposure for 24 h results in increased TNF production...
  31. ncbi Epinephrine absorption in adults: intramuscular versus subcutaneous injection
    F E Simons
    Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Allergy Clin Immunol 108:871-3. 2001
    ..blinded, placebo-controlled, 6-way crossover study of intramuscular versus subcutaneous injection of epinephrine in young men. Peak plasma epinephrine concentrations were significantly higher (P < ...
  32. ncbi Comparison between 1-hour and 24-hour drain clamping using diluted epinephrine solution after total knee arthroplasty
    K Yamada
    Department of Orthopaedic Surgery, Komaki City Hospital, Aichi, Japan
    J Arthroplasty 16:458-62. 2001
    ..trial, 44 primary total knee arthroplasties were studied after the drain-clamping method using diluted epinephrine solution was applied for 1 hour or 24 hours...
  33. ncbi Vasopressin and epinephrine vs. epinephrine alone in cardiopulmonary resuscitation
    Pierre Yves Gueugniaud
    Service d Aide Médicale Urgente 69, Hospices Civils de Lyon, University of Lyon 1, Lyon, France
    N Engl J Med 359:21-30. 2008
    ..of advanced cardiac life support for resuscitation from cardiac arrest, a combination of vasopressin and epinephrine may be more effective than epinephrine or vasopressin alone, but evidence is insufficient to make clinical ..
  34. ncbi Relationship of the functional recovery after hip arthroplasty to the neuroendocrine and inflammatory responses
    G M Hall
    Department of Anaesthesia and Intensive Care Medicine, St George's Hospital Medical School, London, UK
    Br J Anaesth 87:537-42. 2001
    ..Blood samples were collected for up to 7 days after surgery and analysed for concentrations of norepinephrine, epinephrine, cortisol, interleukin-6 and C-reactive protein...
  35. ncbi Variation in epinephrine and cortisol excretion rates associated with behavior in an Australian Aboriginal community
    L H Schmitt
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands, Australia
    Am J Phys Anthropol 106:249-53. 1998
    Urinary epinephrine and cortisol hormone output in a remote Australian Aboriginal community was on average about twice as high in those individuals measured on a Thursday or Friday as those measured at the beginning of the next week (..
  36. ncbi Postoperative analgesia in total hip arthroplasty: a randomized double-blinded, placebo-controlled study on peroperative and postoperative ropivacaine, ketorolac, and adrenaline wound infiltration
    Lasse Juel Andersen
    Department of Orthopaedic Surgery, Odense University Hospital, Middelfart, Denmark
    Acta Orthop 78:187-92. 2007
    ..Comfort and lack of pain are important for optimal mobilization after hip replacement. We investigated the efficacy of double wound infiltration...
  37. ncbi Ischemic, hemodynamic, and neurohormonal responses to mental and exercise stress. Experience from the Psychophysiological Investigations of Myocardial Ischemia Study (PIMI)
    A D Goldberg
    Henry Ford Heart and Vascular Institute, Detroit, MI 48202, USA
    Circulation 94:2402-9. 1996
    ..The pathophysiology of mental stress-induced myocardial ischemia, which occurs at lower heart rates than during physical stress, is not well understood...
  38. ncbi Immunotoxin lesion of hypothalamically projecting norepinephrine and epinephrine neurons differentially affects circadian and stressor-stimulated corticosterone secretion
    Sue Ritter
    Program in Neuroscience, Washington State University, Pullman, Washington 99164 6520, USA
    Endocrinology 144:1357-67. 2003
    Hindbrain norepinephrine (NE) and epinephrine (E) neurons play a pivotal role in the central distribution of sensory signals derived from the internal environment...
  39. ncbi Beta-adrenergic mitogenic signal transduction in peripheral lung adenocarcinoma: implications for individuals with preexisting chronic lung disease
    P G Park
    Carcinogenesis and Developmental Therapeutics Program, College of Veterinary Medicine, University of Tennessee, Knoxville 37909, USA
    Cancer Res 55:3504-8. 1995
  40. ncbi Non-steroidal anti-inflammatory drugs inhibit epinephrine- and cAMP-mediated lipolysis in isolated rat adipocytes
    Piña M de Zentella
    Department of Biochemistry, School of Medicine, National University of Mexico, DF
    J Pharm Pharmacol 54:577-82. 2002
    ..TAG) and thiobarbituric acid reactive substances (TBARS) in liver and promoted the liberation of epinephrine. Four non-steroidal anti-inflammatory drugs (NSAIDs)--aspirin, naproxen, nimesulide and piroxicam--prevented ..
  41. ncbi The periodontal pathogen Porphyromonas gingivalis sensitises human blood platelets to epinephrine
    M Nylander
    Department of Clinical and Experimental Medicine, Division of Clinical Chemistry, Cardiovascular Inflammation Research Centre, Sweden
    Platelets 19:352-8. 2008
    ..gingivalis and the stress hormone epinephrine. By measuring changes in light transmission through platelet suspensions, we found that P...
  42. ncbi Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathway
    Xuan Liu
    Beijing Digestive Diseases Center and Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
    J Cell Biochem 105:53-60. 2008
    ..Stimulation of beta-adrenoceptors with epinephrine significantly increased HKESC-1 cell proliferation accompanied by elevation of intracellular cyclic AMP levels, ..
  43. ncbi The efficacy of perfusion index as an indicator for intravascular injection of epinephrine-containing epidural test dose in propofol-anesthetized adults
    Hany A Mowafi
    Department of Anesthesiology, King Fahd University Hospital, PO Box 40081, Al Khobar 31952, Saudi Arabia
    Anesth Analg 108:549-53. 2009
    ..the efficacy of PI for detecting intravascular injection of a simulated epidural test dose containing 15 mug of epinephrine in adults during propofol-based anesthesia and compared its reliability with the conventional heart rate (HR) (..
  44. pmc A phase III placebo-controlled study in advanced head and neck cancer using intratumoural cisplatin/epinephrine gel
    J A Werner
    Department of Otolaryngology, Philipps University of Marburg, Deutschausstrasse 3, Marburg D 35037, Germany
    Br J Cancer 87:938-44. 2002
    Patients with recurrent or refractory head and neck squamous cell carcinoma received cisplatin/epinephrine injectable gel or placebo gel injected directly into the clinically dominant tumour...
  45. ncbi Nicotine promotes cell proliferation via alpha7-nicotinic acetylcholine receptor and catecholamine-synthesizing enzymes-mediated pathway in human colon adenocarcinoma HT-29 cells
    Helen Pui Shan Wong
    Department of Pharmacology, The University of Hong Kong, Hong Kong, China
    Toxicol Appl Pharmacol 221:261-7. 2007
    ..These data reveal the contributory role alpha7-nAChR and beta-adrenoceptors in the tumorigenesis of colon cancer cells and partly elucidate the carcinogenic action of cigarette smoke on colon cancer...
  46. ncbi GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia
    Huijing Wang
    Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands
    Pain 152:1649-58. 2011
    b>Epinephrine (EPI) contributes to hyperalgesia in inflammatory and stress conditions. EPI signals via adrenoceptors, which are regulated by G protein-coupled receptor kinase 2 (GRK2)...
  47. pmc Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors α3, α5, and α7
    Mohammed H Al-Wadei
    Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Mol Cancer Res 10:239-49. 2012
    ..Our findings identify this hitherto unknown autocrine catecholamine loop as an important regulatory cascade in pancreatic cancer that may prove a promising new target for cancer intervention...
  48. ncbi PKC inhibitors RO 31-8220 and Gö 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation
    Sun Young Kim
    Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    BMB Rep 44:140-5. 2011
    Impaired responsiveness of platelets to epinephrine (epi) and other catecholamines (CA) has been reported in approximately 20% of the healthy Korean and Japanese populations...
  49. ncbi Lack of P-selectin glycoprotein ligand-1 protects mice from thrombosis after collagen/epinephrine challenge
    Kornél Miszti-Blasius
    Department of Clinical Biochemistry and Molecular Pathology, Hungary
    Thromb Res 127:228-34. 2011
    ..Our aim was to establish the role of PSGL-1 in thrombus formation by evaluating the response to thrombotic stimuli in wild type and PSGL-1 knockout mice...
  50. ncbi The comparative effects of lipid, epinephrine, and their combination in the reversal of bupivacaine-induced asystole in the isolated rat heart
    Le Liu
    Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical College, 2 FuXue Road, Wenzhou City, Zhejiang Province, 325000, China
    Anesth Analg 114:886-93. 2012
    It remains unclear whether lipid combined with epinephrine is superior or inferior to either drug alone in treating bupivacaine cardiotoxicity...
  51. ncbi Epinephrine stimulates IL-6 expression in skeletal muscle and C2C12 myoblasts: role of c-Jun NH2-terminal kinase and histone deacetylase activity
    Robert A Frost
    Department of Cellular and Molecular Physiology, Penn State Univ College of Medicine, Hershey Medical Center H166, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 286:E809-17. 2004
    ..The purpose of the present study was to determine whether the stress hormone epinephrine increases inflammatory cytokine expression in skeletal muscle and muscle cells...
  52. pmc Long-term persistance of the pathophysiologic response to severe burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 6:e21245. 2011
  53. ncbi Epinephrine deficiency results in intact glucose counter-regulation, severe hepatic steatosis and possible defective autophagy in fasting mice
    Rana I Sharara-Chami
    Division of Critical Care Medicine, Department of Anesthesiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Int J Biochem Cell Biol 44:905-13. 2012
    b>Epinephrine is one of the major hormones involved in glucose counter-regulation and gluconeogenesis. However, little is known about its importance in energy homeostasis during fasting...
  54. ncbi Low chance of survival among patients requiring adrenaline (epinephrine) or intubation after out-of-hospital cardiac arrest in Sweden
    Mikael Holmberg
    Department of Cardiology, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Resuscitation 54:37-45. 2002
    To relate the outcome of out-of-hospital cardiac arrest to whether medication with adrenaline (epinephrine) was given and whether patients were intubated.
  55. ncbi Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes
    Yongyu Wang
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61822, USA
    J Biol Chem 283:1799-807. 2008
    ..Norepinephrine (NE) and epinephrine (Epi) are two endogenous ligands that activate adrenoceptor (AR) signals in a variety of physiological stress ..
  56. ncbi Parental use of EpiPen for children with food allergies
    Jennifer S Kim
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    J Allergy Clin Immunol 116:164-8. 2005
    ..EpiPen is often underused in children with food allergy experiencing anaphylaxis...
  57. pmc Upregulation of phagocyte-derived catecholamines augments the acute inflammatory response
    Michael A Flierl
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA
    PLoS ONE 4:e4414. 2009
    ..neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both epinephrine and norepinephrine directly activate NFkappaB in macrophages, causing enhanced release of proinflammatory ..
  58. ncbi Recognition, evaluation, and treatment of anaphylaxis in the child care setting
    Priya J Bansal
    Department of Immunology and Microbiology, Rush University Medical Center, Chicago, Illinois, USA
    Ann Allergy Asthma Immunol 94:55-9. 2005
    ..Many young children with a history of allergic reactions or anaphylaxis spend considerable time in child care centers. However, little is known about the centers' knowledge of, experience with, and capability to manage anaphylaxis...
  59. ncbi Dysfunction of releasing adrenaline in asthma by nerve growth factor
    Jun Tao Feng
    Department of Respiratory Medicine, Xiangya Hospital, Central South University, No 141 XiangYa Road, Changsha, Hunan 410008, China
    Med Hypotheses 65:1043-6. 2005
    ..The transdifferentiation (tendency) may impair the functions of endocrine secretion of adrenal medullary cells. As a result, adrenal medulla cannot release enough adrenaline to relieve bronchoconstriction in asthmatic attack...
  60. ncbi ErbB receptors protect the perfused heart against injury induced by epinephrine combined with low-flow ischemia
    Jordi Lorita
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Growth Factors 27:203-13. 2009
    ..ErbB sytem acutely protects the isolated heart in which stress was induced in vitro by ischemia combined with epinephrine infusion (EPI). In perfused mouse hearts, EGF induced Tyr-phosphorylation of ErbB1 but not ErbB2...
  61. pmc Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia
    Wanling Zhu
    Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar St, New Haven, CT, USA
    Am J Physiol Endocrinol Metab 298:E971-7. 2010
    ..the VMH dose-dependently stimulates GABA release, and this in turn dose-dependently suppresses the glucagon and epinephrine responses to hypoglycemia...
  62. ncbi The anesthetic efficacy of 4 percent articaine 1:200,000 epinephrine: two controlled clinical trials
    Paul A Moore
    Department of Anesthesiology, Oral Health Science Institute, School of Dental Medicine, University of Pittsburgh, 552 Salk Hall, Pittsburgh, PA 15261, USA
    J Am Dent Assoc 137:1572-81. 2006
    ..the efficacy and clinical anesthetic characteristics of 4 percent articaine hydrochloride (HCl) with 1:200,000 epinephrine (A200) as compared with those of 4 percent articaine HCl with 1:100,000 epinephrine (A100) and 4 percent ..
  63. ncbi NO production and eNOS phosphorylation induced by epinephrine through the activation of beta-adrenoceptors
    Xavier F Figueroa
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Casilla, Santiago, Chile
    Am J Physiol Heart Circ Physiol 297:H134-43. 2009
    b>Epinephrine plays a key role in the control of vasomotor tone; however, the participation of the NO/cGMP pathway in response to beta-adrenoceptor activation remains controversial...
  64. ncbi Urotensin II acts centrally to increase epinephrine and ACTH release and cause potent inotropic and chronotropic actions
    Anna M D Watson
    Howard Florey Institute, University of Melbourne, Victoria 3010, Australia
    Hypertension 42:373-9. 2003
    ..Plasma epinephrine, adrenocorticotropic hormone, and glucose levels also increased dramatically (+753+/-166 pg/mL, +14.3+/-3...
  65. ncbi Rotational stress-induced increase in epinephrine levels delays cutaneous wound healing in mice
    Bruna Romana-Souza
    Department of Histology and Embryology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
    Brain Behav Immun 24:427-37. 2010
    ..In addition, murine skin fibroblast cultures were treated with high levels of epinephrine and fibroblast activity was evaluated...
  66. ncbi Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation
    Konduru S R Sastry
    Department of Cancer Biology, Section on Comparative Medicine, and Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Biol Chem 282:14094-100. 2007
    The stress hormone epinephrine is known to elicit multiple systemic effects that include changes in cardiovascular parameters and immune responses. However, information about its direct action on cancer cells is limited...
  67. ncbi Detachable snare versus epinephrine injection in the prevention of postpolypectomy bleeding: a randomized and controlled study
    P Di Giorgio
    Gastrointestinal Endoscopy Unit, Pellegrini Hospital, Naples, Italy
    Endoscopy 36:860-3. 2004
    ..Several endoscopic techniques have been developed to prevent bleeding after the removal of large pedunculated polyps...
  68. ncbi Administration of epinephrine for life-threatening allergic reactions in school settings
    C Lynne McIntyre
    Division of Applied Statistics, Evaluation, and Technical Services, Massachusetts Department of Public Health, Boston, Massachusetts, USA
    Pediatrics 116:1134-40. 2005
  69. pmc Multicenter study of repeat epinephrine treatments for food-related anaphylaxis
    Susan A Rudders
    Division of Allergy and Immunology, Children s Hospital Boston, Boston, Massachusetts, USA
    Pediatrics 125:e711-8. 2010
    We sought to establish the frequency of receiving >1 dose of epinephrine in children who present to the emergency department (ED) with food-related anaphylaxis.
  70. ncbi Phase 2 study of intratumoral cisplatin and epinephrine treatment for locally recurrent head and neck tumors
    Christian Duvillard
    Department of Otolaryngology Head and Neck Surgery, Hopital General, Dijon, France
    Ann Otol Rhinol Laryngol 113:229-33. 2004
    ..In experimental studies, epinephrine has been shown to increase the concentration and antitumor effect of intratumoral cisplatin...
  71. ncbi Hypoglycemia-associated autonomic failure in advanced type 2 diabetes
    Scott A Segel
    Division of Endocrinology, Diabetes and Metabolism, and the General Clinical Research Center and the Diabetes Research and Training Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 51:724-33. 2002
    ..and that recent antecedent hypoglycemia shifts the glycemic thresholds for autonomic (including adrenomedullary epinephrine) and symptomatic responses to hypoglycemia to lower plasma glucose concentrations in type 2 diabetes...
  72. ncbi Effects of chai hu (radix burpleuri) containing formulation on plasma beta-endorphin, epinephrine and dopamine on patients
    Jia Xu Chen
    Department of TCM Diagnostics, School of Pre clinical Medicine Beijing University of Traditional Chinese Medicine, Beijing 100029, China
    Am J Chin Med 33:737-45. 2005
    ..performance liquid chromatography (HPLC) was applied to determine the changes of plasma norepinephrine (NE), epinephrine (E) and dopamine (DA)...
  73. ncbi Gene expression of phenylethanolamine N-methyltransferase in corticotropin-releasing hormone knockout mice during stress exposure
    R Kvetnansky
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Cell Mol Neurobiol 26:735-54. 2006
    b>Epinephrine (EPI) synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT, EC is primarily localized in the adrenal medulla (AM)...
  74. ncbi Do not use epinephrine in digital blocks: myth or truth? Part II. A retrospective review of 1111 cases
    Saeed Chowdhry
    University of Louisville, Louisville, KY, USA
    Plast Reconstr Surg 126:2031-4. 2010
    b>Epinephrine in digital blocks has been condemned by traditional medical theory...
  75. ncbi Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters
    H M Schuller
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville 37906, USA
    J Cancer Res Clin Oncol 126:624-30. 2000
    ..We have recently shown that the growth of cell lines derived from human PACs is controlled by beta-adrenergic receptors, and that NNK is a high affinity agonist for this receptor family...
  76. ncbi Repeat epinephrine treatments for food-related allergic reactions that present to the emergency department
    Aleena Banerji
    Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Allergy Asthma Proc 31:308-16. 2010
    To date, there are sparse data on epinephrine treatment for food-related anaphylaxis in adults...
  77. pmc Asthma pregnancy alters postnatal development of chromaffin cells in the rat adrenal medulla
    Xiu Ming Wu
    Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China
    PLoS ONE 6:e20337. 2011
    ..Adrenal neuroendocrine plays an important role in asthma. The activity of the sympathoadrenal system could be altered by early life events. The effects of maternal asthma during pregnancy on the adrenal medulla of offspring remain unknown...
  78. ncbi What are the 'ideal' features of an adrenaline (epinephrine) auto-injector in the treatment of anaphylaxis?
    A J Frew
    Department of Respiratory Medicine, Royal Sussex County Hospital, Brighton, UK
    Allergy 66:15-24. 2011
  79. ncbi Stress hormone changes in general anesthesia of long duration: isoflurane-nitrous oxide vs sevoflurane-nitrous oxide anesthesia
    Tomoki Nishiyama
    Department of Anesthesiology, Faculty of Medicine, The University of Tokyo, 113 8655 Tokyo, Japan
    J Clin Anesth 17:586-91. 2005
    ..We investigated perioperative changes of stress hormone in these two anesthetic methods with duration of more than 10 hours...
  80. ncbi A second dose of epinephrine for anaphylaxis: how often needed and how to carry
    John M Kelso
    J Allergy Clin Immunol 117:464-5. 2006
  81. ncbi Is intraperitoneal levobupivacaine with epinephrine useful for analgesia following laparoscopic cholecystectomy? A randomized controlled trial
    A Ng
    Leicester Royal Infirmary, University Department of Anaesthesia, Critical Care and Pain Management, Leicester, UK
    Eur J Anaesthesiol 21:653-7. 2004
    ..To evaluate whether the instillation of levobupivacaine, with epinephrine, intraperitoneally, reduces morphine consumption; further, to consider the degree of abdominal and shoulder ..
  82. ncbi Adrenal adrenaline- and noradrenaline-containing cells and celiac sympathetic ganglia are differentially controlled by centrally administered corticotropin-releasing factor and arginine-vasopressin in rats
    Naoko Yamaguchi-Shima
    Department of Pharmacology, Graduate School of Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    Eur J Pharmacol 564:94-102. 2007
    ..On the other hand, centrally administered AVP activates adrenal A-cells and NA-cells by brain thromboxane A2-mediated mechanisms in rats...
  83. ncbi Epinephrine concentration (1:100,000 or 1:200,000) does not affect the clinical efficacy of 4% articaine for lower third molar removal: a double-blind, randomized, crossover study
    Carlos F Santos
    Bauru School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil
    J Oral Maxillofac Surg 65:2445-52. 2007
    This study compared the use of 4% articaine in association with 1:100,000 (10 mug/mL; A100) or 1:200,000 (5 mug/mL; A200) epinephrine in lower third molar removal.
  84. pmc Treating delayed endoscopic sphincterotomy-induced bleeding: epinephrine injection with or without thermotherapy
    Yung Kuan Tsou
    Department of Hepato Gastroenterology, Division of Therapeutic Endoscopy, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei, Taiwan, ROC
    World J Gastroenterol 15:4823-8. 2009
    To compare the hemostatic efficacy between epinephrine injection alone and epinephrine injection combined with thermotherapy for delayed post-endoscopic sphincterotomy (ES) bleeding.
  85. ncbi An investigation of changes in physical properties of injectable calcium hydroxylapatite in a carrier gel when mixed with lidocaine and with lidocaine/epinephrine
    Mariano Busso
    University of Miami, Coral Gables, Florida, USA
    Dermatol Surg 34:S16-23; discussion S24. 2008
  86. pmc Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas
    Hussein A N Al-Wadei
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA
    J Pathol 218:437-45. 2009
    ..These findings suggest that NNK-induced alterations in regulatory nAChRs may contribute to the development of smoking-associated PAC and PDAC by disturbing the balance between cancer-stimulating and -inhibiting neurotransmitters...
  87. ncbi Femoral nerve block for total knee arthroplasty patients: a method to control postoperative pain
    Myron J Szczukowski
    Orthopedic Center, Easton, Maryland 21601, USA
    J Arthroplasty 19:720-5. 2004
    ..5% bupivacaine with epinephrine 1:200,000, on pain control following total knee arthroplasty (TKA)...
  88. ncbi Efficacy of periarticular multimodal drug injection in total knee arthroplasty. A randomized trial
    Constant A Busch
    Division of Orthopaedic Surgery, London Health Sciences Centre, London, Ontario, Canada
    J Bone Joint Surg Am 88:959-63. 2006
    ..Good perioperative analgesia facilitates rehabilitation, improves patient satisfaction, and may reduce the hospital stay. We investigated the analgesic effect of locally injected drugs around a total knee prosthesis...
  89. ncbi Decrease in intramuscular lipid droplets and translocation of HSL in response to muscle contraction and epinephrine
    Clara Prats
    Copenhagen Muscle Research Center, Department of Medical Physiology, Panum Institute, University of Copenhagen, Copenhagen N, Denmark
    J Lipid Res 47:2392-9. 2006
    ..of this study was to characterize the PAT family proteins associated with IMTG and to investigate the effect of epinephrine stimulation or muscle contraction on skeletal muscle TG content and HSL intracellular distribution...
  90. pmc Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis
    Anil K Sood
    Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 120:1515-23. 2010
    ..Here, we demonstrate that human ovarian cancer cells exposed to either norepinephrine or epinephrine exhibit lower levels of anoikis, the process by which cells enter apoptosis when separated from ECM and ..
  91. pmc Cortisol and epinephrine control opposing circadian rhythms in T cell subsets
    Stoyan Dimitrov
    Departments of Neuroendocrinology, University of Lubeck, Germany
    Blood 113:5134-43. 2009
    ..Effector CD8(+) T cells were positively correlated with epinephrine rhythms, increased after low-dose epinephrine infusion, and showed highest expression of beta-adrenergic and ..
  92. ncbi Maternal perinatal undernutrition alters postnatal development of chromaffin cells in the male rat adrenal medulla
    Olivier Molendi-Coste
    Unité de Neurosciences et Physiologie Adaptatives, UPRES EA 4052, Equipe dénutritions maternelles périnatales, SN4, Universite de Lille I, Villeneuve d Ascq, France
    Neuroendocrinology 90:54-66. 2009
    ..This might contribute to the long-lasting malprogramming of the adrenal medulla and to the development of chronic adult diseases...
  93. ncbi Targeted insertion of the Cre-recombinase gene at the phenylethanolamine n-methyltransferase locus: a new model for studying the developmental distribution of adrenergic cells
    Steven N Ebert
    Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20057, USA
    Dev Dyn 231:849-58. 2004
    ..distribution of adrenergic cells in vivo, we inserted the Cre-recombinase gene into the locus encoding for the epinephrine biosynthetic enzyme phenylethanolamine n-methyltransferase (Pnmt) and crossed these Pnmt-Cre mice with ROSA26 ..
  94. ncbi Vasopressin, epinephrine, and corticosteroids for in-hospital cardiac arrest
    Spyros D Mentzelopoulos
    First Department of Intensive Care Medicine, University of Athens Medical School, Athens, Greece
    Arch Intern Med 169:15-24. 2009
    Animal data on cardiac arrest showed improved long-term survival with combined vasopressin-epinephrine. In cardiac arrest, cortisol levels are relatively low during and after cardiopulmonary resuscitation...
  95. ncbi Self-injectable epinephrine for first-aid management of anaphylaxis
    Scott H Sicherer
    Pediatrics 119:638-46. 2007
    ..Anaphylaxis is a severe, potentially fatal systemic allergic reaction that is rapid in onset and may cause death. Epinephrine is the primary medical therapy, and it must be administered promptly...
  96. pmc Reduced hospital stay, morphine consumption, and pain intensity with local infiltration analgesia after unicompartmental knee arthroplasty
    Per Essving
    Department of Orthopedic Surgery, University of Linkoping, Sweden
    Acta Orthop 80:213-9. 2009
    ..The degree of postoperative pain is usually moderate to severe following knee arthroplasty. We investigated the efficacy of local administration of analgesics into the operating area, both intraoperatively and postoperatively...
  97. ncbi Mechanisms of abnormal cardiac repolarization during insulin-induced hypoglycemia
    Robert T C E Robinson
    Clinical Sciences Center, Northern General Hospital, University of Sheffield, Sheffield S57 AU, U K
    Diabetes 52:1469-74. 2003
    ..Sympathoadrenal stimulation is the main cause, through mechanisms that involve but are not limited to catecholamine-mediated hypokalemia. These abnormalities are prevented by selective beta-blockade...
  98. ncbi Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes
    Marc Brede
    Institut fur Pharmakologie und Toxikologie, Universitat Wurzburg, 97078 Wurzburg, Germany
    Mol Endocrinol 17:1640-6. 2003
    ..nerves is regulated by presynaptic inhibitory alpha2-adrenoceptors, but it is unknown whether release of epinephrine from the adrenal gland is controlled by a similar short feedback loop...
  99. ncbi Arginine vasopressin, but not epinephrine, improves survival in uncontrolled hemorrhagic shock after liver trauma in pigs
    Wolfgang G Voelckel
    Departments of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Innsbruck, Austria
    Crit Care Med 31:1160-5. 2003
    b>Epinephrine is widely used for treatment of life-threatening hypotension, although new vasopressor drugs may merit evaluation. The purpose of this study was to determine the effects of vasopressin vs. epinephrine vs...
  100. ncbi Stress-induced changes in skin barrier function in healthy women
    M Altemus
    Department of Psychiatry, Weill Medical College, Cornell University, New York, New York 10021, USA
    J Invest Dermatol 117:309-17. 2001
    ..These results suggest that acute psychosocial and sleep deprivation stress disrupts skin barrier function homeostasis in women, and that this disruption may be related to stress-induced changes in cytokine secretion...
  101. ncbi Triidothyronine and epinephrine rapidly modify myocardial substrate selection: a (13)C isotopomer analysis
    J J Krueger
    Division of Cardiology, Department of Pediatrics, University of Washington, School of Medicine, Seattle 98195, USA
    Am J Physiol Endocrinol Metab 281:E983-90. 2001
    ..substrate selection and flux, was tested in isovolumic rat hearts under four conditions: control, T(3) (10 nM), epinephrine (Epi), and T(3) and Epi (TE). Hearts were perfused with [1,3-(13)C]acetoacetic acid (AA, 0...

Research Grants63

  1. Role of Subdiaphragmatic Vagus in Fibromyalgia Syndrome
    JON DAVID LEVINE; Fiscal Year: 2013
    ..in hyperalgesia evoked by injection of the pronociceptive inflammatory mediator prostaglandin E2 (PGE2) or epinephrine in the skin...
  2. Regulation of alpha2A-adrenergic receptor signaling and trafficking by spinophili
    Qin Wang; Fiscal Year: 2013
    ..In addition to epinephrine (an endogenous ligand), we will study ?2AAR trafficking induced by clonidine and guanfacine (two ?2-agonists ..
  3. Inducible recombination and gene expression in specific neurotransmitter systems
    Steven A Thomas; Fiscal Year: 2012
    ..The four are the adrenergic (norepinephrine and epinephrine), dopaminergic, serotonergic and orexinergic systems...
  4. Quorum sensing regulation of EHEC virulence genes
    Vanessa Sperandio; Fiscal Year: 2013
    ..genes: a bacterial aromatic autoinducer (AI-3) produced by the normal gastrointestinal flora, and two hormones (epinephrine/norepinephrine) produced by the host...
  5. Mechanisms of airborne particulate matter induced thrombosis
    Gokhan M Mutlu; Fiscal Year: 2013
    ..We also observed that mice exposed to inhaled PM had increased lung and systemic levels of epinephrine and norepinephrine, directly confirming data from human exposure studies suggesting that PM exposure activates ..
  6. Cognitive Behavioral Therapy for Insomnia in Stable Heart Failure
    Nancy S Redeker; Fiscal Year: 2010
    ..We will also obtain day and night measures of urinary free cortisol, free epinephrine/norepinephrine, and melatonin sulfate...
  7. CNS Mechanisms of Acute Hypoglycemia-Associate Autonomic Failure
    ..counterregulatory response (CRR), a hormonal and neural response that includes sympathoadrenal activation and epinephrine (EPI) release;activation of the hypothalamic/pituitary/adrenal (HPA) axis and release of adrenal ..
  8. Mechanisms of Neurotransmitter Biosynthesis
    Paul F Fitzpatrick; Fiscal Year: 2011
    ..hydroxylase results in phenylketonuria;tyrosine hydroxylase is required to make the neurotransmitters dopamine, norepinephrine, and epinephrine;and tryptophan hydroxylase is required to synthesize the neurotransmitter serotonin.
  9. Mechanism for Reduced Adrenomedullary Epinephrine Release in Type 1 Diabetes
    BRANLY OSVALDO ORBAN; Fiscal Year: 2012
    ..In its absence, other circulating CRR hormones, such as epinephrine, take on primary importance in restoring plasma glucose to basal levels...
    Gary V Desir; Fiscal Year: 2010
    ..25 fold increase) by either modest increases in blood pressure and/or brief surges in either plasma dopamine, epinephrine or norepinephrine...
  11. Intervention for Menstrual Mood Disorders &Early Life Abuse: Biopsych Mechanisms
    Susan S Girdler; Fiscal Year: 2013
    ..response to mental stress: 1) sympathetic nervous system (blood pressure, heart rate, plasma norepinephrine and epinephrine);2) hypothalamic-pituitary-adrenal (plasma ACTH and cortisol);3) inflammatory (plasma IL-6);and 4) cardiac ..
  12. The geriatric surgical patient: stress, anesthetics, and functional outcomes
    Stacie Deiner; Fiscal Year: 2012
    ..activation of the stress response as evidenced by serum cortisol, lower plasma levels of norepinephrine (NE), epinephrine (E), and growth hormone (GH), and lesser heart rate variability (HRV)...
  13. Modeling Individual Differences in PTSD
    Marlene A Wilson; Fiscal Year: 2013
    ..adrenal (HPA) activity and other indices of sympathetic activation including norepinephrine (NE) and epinephrine (EPI) levels...
  14. Persistent COMT-dependent Pain: Role of beta-adrenergic Receptors
    ANDREA G NACKLEY NEELY; Fiscal Year: 2013
    ..dependent pain is mediated in part by peripheral adrenergic systems as adrenalectomized rats lacking peripheral epinephrine exhibit reduced COMT-dependent pain sensitivity...
  15. Alpha-1A-adrenergic agonist therapy for cardiomyopathy and heart failure
    Paul C Simpson; Fiscal Year: 2013
    ..The catecholamines norepinephrine (NE) and epinephrine (EPI) activate two types of ARs on cardiac muscle cells, the dominant beta-ARs, which increase heart ..
  16. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2011
    ..When epinephrine is used to compromise the blood-brain barrier, the antibodies damage neurons in the amygdala and cause a ..
  17. Host pathogen signaling in the intestine
    Vanessa Sperandio; Fiscal Year: 2013
    ..coli (EHEC) O157:H7 exploits sensing the host's stress hormones epinephrine (epi) and norepinephrine (NE) to activate its virulence traits...
  18. Mechanisms of the Relaxation Response in Elderly Hypertensives
    Jeffery A Dusek; Fiscal Year: 2010
    ..effects and that this occurs by increasing nitric oxide production and/or by reducing stress hormone levels (epinephrine and cortisol)...
  19. Hyperphenylalaninemia in cerebral malaria
    DONALD LEE GRANGER; Fiscal Year: 2010
    ..metabolic product, tyrosine (Tyr), is the substrate for the biogenic amine neurotransmitters (BAN), dopamine, epinephrine and norepinephrine...
  20. Interaction of RGS Protein with G beta subunit G beta 5.
    Vladlen Z Slepak; Fiscal Year: 2013
    ..The experimental design is based on the discovery that Gbeta5 knockout mice have an increased level of epinephrine, which is consistent with high locomotor activity and other changes in these animals...
  21. Stress Impaired Microbial Clearance
    Phillip T Marucha; Fiscal Year: 2012
    ..Activation of the HPA axis results in the release of glucocorticoids and epinephrine, which are known to inhibit the immune system...
  22. Overcoming established anaphylactic hypersensitivity to peanuts
    Kelvin P Lee; Fiscal Year: 2013
    ..Current management is limited to strict avoidance and rescue epinephrine upon exposure...
  23. Myocardial Effects of Erythropoietin During Resuscitation from Cardiac Arrest
    RAUL JAIME GAZMURI; Fiscal Year: 2013
    ..to examine the effects of erythropoietin in the presence or absence of concomitant administration of epinephrine on the hemo- dynamic efficacy of chest compression, initial resuscitation, post-resuscitation myocardial ..
    Gary V Desir; Fiscal Year: 2010
    ..Renalase is an amine oxidase that metabolizes catecholamines such as dopamine, epinephrine and norepinephrine...
  25. Sleep and biological rhythms after fetal exposure to antidepressants
    Amy L Salisbury; Fiscal Year: 2013
    ..organization, 24-hour sleep-wake rhythms, and diurnal urinary excretion of melatonin sulfate, cortisol, epinephrine, and norepinephrine...
  26. Imaging Adrenergic Stimulation of Brown Adipose Tissue
    Jogeshwar Mukherjee; Fiscal Year: 2012
    ..The direct involvement of adrenergic system (epinephrine/norepinephrine and [unreadable]3 adrenergic receptor) via the uncoupling protein (UCP) in BAT thermogenesis has ..
  27. Adolescent alcohol exposure and altered adult HPA axis activity
    SOON O LEE; Fiscal Year: 2013
    ..circuitry of adult rats exposed to AIE, differs from that of control animals;that the ability of (nor)epinephrine, which is released by alcohol in the brain, to activate the HPA axis, is also altered by AIE;and that the role ..
  28. Variation in platelet function: the genetics of platelet gene expression
    Paul F Bray; Fiscal Year: 2013
    ..Our previous genome wide scan and platelet RNA expression studies have elucidated mechanisms for epinephrine-induced platelet aggregation, identified mRNA expression differences, as well as unexpected evidence that ..
  29. Mechanisms of beta-blocker induced improvements in asthma
    Julia K L Walker; Fiscal Year: 2013
    ..apos;sympathectomy', as well as bone marrow transplant experiments, determine the cellular source of the epinephrine activating the [unreadable]2AR allowing its various pro-asthmatic effects, and because weeks of treatment ..
  30. Identify Driving Risk Factors in T1DM and their Reduction via Behav Intervention
    DANIEL JOSEPH COX; Fiscal Year: 2012
    ..2) Physical: they require more glucose to maintain euglycemia, and release less epinephrine and experience greater driving impairment during mild hypoglycemia...
  31. Glucose and age-Related Memory Impairments
    Ken Morris; Fiscal Year: 2013
    ..Previous work in rodents and humans indicates that increases in blood glucose in response to endogenous epinephrine release are important for regulating memory formation and durability...
  32. A Picture is Worth 1000 Calories: The Neuroimaging of Obesity
    Kristen Eckstrand; Fiscal Year: 2013
    ..insulin enhances the surface expression of the dopamine transporter (DAT) while inhibiting that of the nor epinephrine transporter (NET)...
  33. Structural Studies of Vesicular Monoamine Transporters
    SATINDER KAUR SINGH; Fiscal Year: 2013
    ..Substrates include serotonin, dopamine, norepinephrine, epinephrine, and histamine...
  34. Actions of Melanin Concentrating Hormone in the Brain
    Eleftheria Maratos Flier; Fiscal Year: 2010
    ..we will explore the hypothesis that we developed that MCH acts to suppress autonomic activity by evaluating nor-epinephrine turnover in mice lacking MCH as well as mice lacking both MCH and leptin...
  35. Novel therapy for cardiotoxicity of cancer drugs
    Paul C Simpson; Fiscal Year: 2013
    ..along with beta-ARs and alpha-2-ARs, are G-protein-coupled receptors for the catecholamines norepinephrine and epinephrine. Alpha-1-ARs exist as three molecular subtypes, named A, B, and D...
  36. Hypoglycemia and alpha cell regulation
    Joseph Bryan; Fiscal Year: 2009
    ..Glucagon secretion is potently stimulated by epinephrine and norepinephrine, but the relative importance of local control of [unreadable]-cell function vs their ..
  37. Regulation of lipoprotein lipase in adipocytes
    Philip A Kern; Fiscal Year: 2011
    ..of LPL, which occurs in response to diabetes, and in response to hormones such as thyroid hormone and epinephrine. LPL translation is controlled by an RNA binding complex, consisting of a member of the A-Kinase Anchoring ..
  38. Regulation of EHEC virulence genes by QseA and small RNA molecules
    Melissa Kendall; Fiscal Year: 2009
    ..senses a bacterial autoinducer (AI-3) produced by the normal gastrointestinal flora, as well as the hormones epinephrine and norepinephrine produced by the host to activate expression of its virulence genes...
    Laura Decastro; Fiscal Year: 2011
    ..Physiologic concentrations of epinephrine increase adhesion of SS RBCs as well as their ability to stimulate leukocyte adhesion, which then leads to ..
  40. The a-catulin/dystrophin-associated protein complex regulates GPCR function
    Chris Hague; Fiscal Year: 2013
    ..receptors (ARs) are G-protein coupled receptors (GPCRs) that respond to sympathetic hormones norepinephrine and epinephrine, and are therapeutic targets for the treatment of hypertension, benign prostrate hypertrophy (BPH), and post-..
  41. Determinants of gestational weight gain in obese pregnant women
    LEANNE MAREE REDMAN; Fiscal Year: 2013
    ..of energy intake including fasting concentrations of leptin, total ghrelin, peptide YY, cholecystokinin and determinants of energy expenditure including urinary epinephrine and norepinephrine, fasting concentrations of T3, T4 and TSH.
    Curt Freed; Fiscal Year: 1991
    ..success of these drugs, there is no detailed knowledge of how individual brainstem nuclei use norepinephrine, epinephrine, dopamine and serotonin during changes in blood pressure...
  43. Stress-activated signaling in prostate cancer
    GEORGE A KULIK; Fiscal Year: 2012
    We have demonstrated that epinephrine at concentrations observed during stress induces PKA-dependent phosphorylation of the pro-apoptotic protein BAD and protects prostate cancer cells from apoptosis (JBC2007 in "appendix")...
  44. Anti-Microbial Antibodies Induce Neuropsychiatric Syndromes
    Betty Diamond; Fiscal Year: 2011
    ..b>Epinephrine, one of the hormones activated by fear and traumatic stress, opens the blood-brain barrier and allows ..
  45. Neuropeptide Y and the Control of Catecholamine Secretion from the Adrenal Gland
    MATTHEW WHIM; Fiscal Year: 2012
    ..of the mammalian adrenal gland is composed of sympathetic neurons that release the catecholamine hormones, epinephrine and norepinephrine, into the blood...
  46. Glucose Counterregulation in Long Standing Type 1 Diabetes
    Michael R Rickels; Fiscal Year: 2013
    ..Without intact islet or sympathoadrenal (especially epinephrine) responses to hypoglycemia, these patients cannot increase endogenous (primarily hepatic) glucose production to ..
  47. Improving Food Allergy Management through an Electronic Physician Support Tool
    Ruchi S Gupta; Fiscal Year: 2013
    ..obtaining an appropriate clinical history and testing;2) physicians are not consistently prescribing injectable epinephrine;and 3) little counseling about food allergy management is being documented in the medical record...
    UDAY DEVASKAR; Fiscal Year: 1999
    ..Fetal CNS autonomic sympathetic or parasympathetic neurotransmission, or 3) Fetal adrenal medullary release of Epinephrine (beta-a drenergic effect)...
    Tarun Patel; Fiscal Year: 1991
    Regulation of hepatic gluconeogenesis by hormones such as glucagon, insulin, epinephrine, vasopressin and angiotensin is well established...
  50. "Innate intestinal responses in murine toxoplasmosis"
    Fernando Monroy; Fiscal Year: 2005
    ..to the release of glucocorticoids (corticosterone) from the adrenal cortex, and release of catecholamines (epinephrine, nor-epinephrine) from sympathetic nerve terminals and the adrenal medulla...
    ERIC FEIGL; Fiscal Year: 1999
    ..hypothesis that there is beta-receptor-mediated coronary vasodilation when oxygen consumption is augmented by epinephrine infusion and determine the dose-response relation for arterial epinephrine that causes coronary beta-..
    David Bylund; Fiscal Year: 1993
    Norepinephrine and epinephrine are important neurotransmitters in the central nervous system, and alpha-2 adrenergic receptors, which are coupled to the inhibition of adenylate cyclase, are widely distributed...
    Thomas Bell; Fiscal Year: 1991
    ..to adenosine diphosphate (ADP), platelet activating factor (PAF), or A23187; is reversible in response to epinephrine; and complete in response to phorbol myristate acetate (PMA) or concentrations of thrombin greater than 0...
  54. CNS Counterregulatory Mechanisms
    Lauren Jacobson; Fiscal Year: 2004
    ..Adrenomedullary epinephrine secretion is one of the most rapidly effective and readily preserved defenses against hypoglycemia...
    Barry Shulkin; Fiscal Year: 2002
    ..b>Epinephrine is a naturally occurring catecholamine product of the adrenal medulla and of some pheochromocytomas...
  56. Medical Management of Pediatric Neurotransmitter Disorders- A Multidisciplinary
    K Michael Gibson; Fiscal Year: 2007
    ..Neurotransmitters such as dopamine, epinephrine, serotonin and GABA are critical in CNS activities that include regulation of body temperature and pain ..
    William Burke; Fiscal Year: 1993
    ..neurotoxin; 2) to determine whether in Alzheimer's disease (AD) the concentration of DOPEGAL increases in epinephrine (Epi) nerve cell bodies where it has access to DNA and where binding to DNA could decrease transcription of the ..
    Elaine Lewis; Fiscal Year: 1991
    The rate of biosynthesis of the catecholamines dopamine, norepinephrine and epinephrine, can be modulated by numerous neuronal, hormonal and environmental influences...
    TAG MANSOUR; Fiscal Year: 1990
    ..It is also involved in the effect of epinephrine and of insulin on cellular metabolism...
    Dennis Jensen; Fiscal Year: 1999
    ..In studies I-III which are blinded, multicenter randomized trials, our hypothesis is that combination therapy (epinephrine injection +bipolar electrocoagulation-BP)will be significantly better than single therapy (BP) for initial ..
    MARVIN BROWN; Fiscal Year: 1992
    ..is to determine the role of brain somatostatin in the regulation of pituitary vasopressin and adrenal epinephrine secretion...
  62. The Role of Epinephrine in Neurally Mediated Syncope
    Satish Raj; Fiscal Year: 2009
    ..Recent studies have found that the level of epinephrine rises PRIOR to syncope...
    Alan Cherrington; Fiscal Year: 2007
    ..affect one another in vivo, 2) the way in which certain of the counterregulatory hormones (glucagon and epinephrine; cortisol and epinephrine) interact to control glycogenolysis and gluconeogenesis, 3) the extent to which ..