Summary: A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.

Top Publications

  1. ncbi Neurohumoral features of myocardial stunning due to sudden emotional stress
    Ilan S Wittstein
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 352:539-48. 2005
  2. pmc Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
    Khoa D Nguyen
    Immunology Program, Stanford University, Palo Alto, California 94305, USA
    Nature 480:104-8. 2011
  3. ncbi Stress at the intestinal surface: catecholamines and mucosa-bacteria interactions
    Mark Lyte
    Department of Pharmacy Practice, Texas Tech University Health Sciences Center, 3601 4th Street, MS 8162, Lubbock, TX 79430 8162, USA
    Cell Tissue Res 343:23-32. 2011
  4. ncbi Phagocyte-derived catecholamines enhance acute inflammatory injury
    Michael A Flierl
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nature 449:721-5. 2007
  5. ncbi Catecholaminergic systems in stress: structural and molecular genetic approaches
    Richard Kvetnansky
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Physiol Rev 89:535-606. 2009
  6. pmc Influence of brain catecholamines on the development of fatigue in exercising rats in the heat
    Hiroshi Hasegawa
    Laboratoruy of Exercise Physiology, Graduate School of Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi Hiroshima, Japan
    J Physiol 586:141-9. 2008
  7. ncbi Rapid, nongenomic responses to ecdysteroids and catecholamines mediated by a novel Drosophila G-protein-coupled receptor
    Deepak P Srivastava
    The Inositide Laboratory, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    J Neurosci 25:6145-55. 2005
  8. ncbi Biochemical diagnosis of pheochromocytoma: which test is best?
    Jacques W M Lenders
    Department of Internal Medicine, St Radboud University Medical Center, Geert Grooteplein Zuid 8, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    JAMA 287:1427-34. 2002
  9. pmc Catecholaminergic polymorphic ventricular tachycardia: RYR2 mutations, bradycardia, and follow up of the patients
    A V Postma
    J Med Genet 42:863-70. 2005
  10. ncbi Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists
    Jacob Abraham
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Am Coll Cardiol 53:1320-5. 2009

Detail Information

Publications313 found, 100 shown here

  1. ncbi Neurohumoral features of myocardial stunning due to sudden emotional stress
    Ilan S Wittstein
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 352:539-48. 2005
    ..Reversible left ventricular dysfunction precipitated by emotional stress has been reported, but the mechanism remains unknown...
  2. pmc Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
    Khoa D Nguyen
    Immunology Program, Stanford University, Palo Alto, California 94305, USA
    Nature 480:104-8. 2011 cold temperature rapidly promoted alternative activation of adipose tissue macrophages, which secrete catecholamines to induce thermogenic gene expression in brown adipose tissue and lipolysis in white adipose tissue...
  3. ncbi Stress at the intestinal surface: catecholamines and mucosa-bacteria interactions
    Mark Lyte
    Department of Pharmacy Practice, Texas Tech University Health Sciences Center, 3601 4th Street, MS 8162, Lubbock, TX 79430 8162, USA
    Cell Tissue Res 343:23-32. 2011
    ..Moreover, changes in host-microbe interactions in the digestive tract may also influence ongoing neural activity in stress-responsive brain areas...
  4. ncbi Phagocyte-derived catecholamines enhance acute inflammatory injury
    Michael A Flierl
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nature 449:721-5. 2007
    ..We investigated whether phagocytes are capable of de novo production of catecholamines, suggesting an autocrine/paracrine self-regulatory mechanism by catecholamines during inflammation, as has ..
  5. ncbi Catecholaminergic systems in stress: structural and molecular genetic approaches
    Richard Kvetnansky
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Physiol Rev 89:535-606. 2009
    ..of catecholamine systems and the molecular genetics of enzymes involved in biosynthesis and degradation of catecholamines and transporters...
  6. pmc Influence of brain catecholamines on the development of fatigue in exercising rats in the heat
    Hiroshi Hasegawa
    Laboratoruy of Exercise Physiology, Graduate School of Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi Hiroshima, Japan
    J Physiol 586:141-9. 2008
    ..Moreover, these results support previous findings in humans that acute bupropion ingestion increases T(core) during exercise in the heat, indicating the possibility of an important role for DA and NA in thermoregulation...
  7. ncbi Rapid, nongenomic responses to ecdysteroids and catecholamines mediated by a novel Drosophila G-protein-coupled receptor
    Deepak P Srivastava
    The Inositide Laboratory, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    J Neurosci 25:6145-55. 2005
    ..Thus, DmDopEcR can function as a cell-surface GPCR that may be responsible for some of the rapid, nongenomic actions of ecdysteroids, during both development and signaling in the mature adult nervous system...
  8. ncbi Biochemical diagnosis of pheochromocytoma: which test is best?
    Jacques W M Lenders
    Department of Internal Medicine, St Radboud University Medical Center, Geert Grooteplein Zuid 8, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    JAMA 287:1427-34. 2002
    ..Diagnosis of pheochromocytoma depends on biochemical evidence of catecholamine production by the tumor. However, the best test to establish the diagnosis has not been determined...
  9. pmc Catecholaminergic polymorphic ventricular tachycardia: RYR2 mutations, bradycardia, and follow up of the patients
    A V Postma
    J Med Genet 42:863-70. 2005
    ..The aim of the study was to assess underlying genetic cause(s), clinical features, and response to therapy in catecholaminergic polymorphic ventricular tachycardia (CPVT) probands...
  10. ncbi Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists
    Jacob Abraham
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Am Coll Cardiol 53:1320-5. 2009
    The aim of this study was to report a series of patients with stress cardiomyopathy precipitated by the intravenous administration of catecholamines and beta-receptor agonists.
  11. ncbi Sources and significance of plasma levels of catechols and their metabolites in humans
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620
    J Pharmacol Exp Ther 305:800-11. 2003
    Human plasma contains several catechols, including the catecholamines norepinephrine, epinephrine, and dopamine, their precursor, L-3,4-dihydroxyphenylalanine (L-DOPA), and their deaminated metabolites, dihydroxyphenylglycol, the main ..
  12. ncbi Catecholamine systems in the brain of vertebrates: new perspectives through a comparative approach
    W J Smeets
    Graduate School of Neurosciences of Amsterdam, Research Institute of Neurosciences, Amsterdam, The Netherlands
    Brain Res Brain Res Rev 33:308-79. 2000
    ..contain catecholaminergic cell groups, of which the counterparts in amniotes have lost the capacity to produce catecholamines. Moreover, a segmental approach in studying the organization of catecholaminergic systems is advocated...
  13. ncbi Obstructive sleep apnoea and urine catecholamines in hypertensive males: a population-based study
    A Elmasry
    Dept of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Akademiska sjukhuset, Sweden
    Eur Respir J 19:511-7. 2002
    ..The aim of this study was to investigate the relationship between OSA and urinary catecholamines in a population-based sample of hypertensive males...
  14. pmc A new role for the dynamin GTPase in the regulation of fusion pore expansion
    Arun Anantharam
    Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Biol Cell 22:1907-18. 2011
    ..These findings expand the membrane-sculpting repertoire of dynamin to include the regulation of immediate postfusion events in exocytosis that control the rate of release of soluble granule contents...
  15. ncbi Blood sampling methodology is crucial for precise measurement of plasma catecholamines concentrations in mice
    Eric Grouzmann
    Division of Clinical Pharmacology and Toxicology, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Pflugers Arch 447:254-8. 2003
    ..In conclusion, arterial-catheter and retro-orbital blood sampling methods appear to be the most accurate procedures for studying the sympathetic nervous system in mice in both unstressed and stressed conditions...
  16. ncbi Randomized trial of phosphodiesterase inhibitors versus catecholamines in patients with acutely decompensated heart failure
    A Kawamura
    Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Jpn Circ J 65:858-62. 2001
    ..The present study was designed to test the hypothesis that phosphodiesterase inhibitors, but not catecholamines, could favorably affect neurohormone and cytokine profiles in patients with acutely decompensated heart ..
  17. ncbi Evidence that female endocrine state influences catecholamine responses to male courtship song in European starlings
    Lauren V Riters
    Department of Zoology, University of Wisconsin, 361 Birge Hall, 430 Lincoln Drive, Madison, WI 53706, USA
    Gen Comp Endocrinol 154:137-49. 2007
    ..The catecholamines dopamine and norepinephrine regulate behaviors important for mate choice such as arousal, attention, sexual ..
  18. pmc The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release
    Hongdong Bai
    Department of Medicine, University of California, San Diego, La Jolla, California 92037, USA
    J Biol Chem 286:33125-33. 2011
    ..Plg-R(KT) thus represents a new mechanism and novel control point for regulating the interface between plasminogen activation and neurosecretory cell function...
  19. pmc Estradiol-dependent catecholaminergic innervation of auditory areas in a seasonally breeding songbird
    Lisa L Matragrano
    Department of Psychology, Emory University, 26 Eagle Row, Atlanta, GA, USA
    Eur J Neurosci 34:416-25. 2011
    ..plasma E2 typical of the breeding season enhanced catecholaminergic innervation and synthesis in some parts of the auditory system, raising the possibility that catecholamines play a role in E2-dependent auditory plasticity in songbirds.
  20. ncbi Adipocytes as a new source of catecholamine production
    Peter Vargovic
    Laboratory of Stress Research, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia
    FEBS Lett 585:2279-84. 2011
    b>Catecholamines are an important regulator of lipolysis in adipose tissue. Here we show that rat adipocytes, isolated from mesenteric adipose tissue, express genes of catecholamine biosynthetic enzymes and produce catecholamines de novo...
  21. ncbi Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity
    Ilia J Elenkov
    Division of Rheumatology, Immunology and Allergy, Georgetown University Medical Center, Washington, DC 20007, USA
    Ann N Y Acad Sci 966:290-303. 2002
    Recent evidence indicates that glucocorticoids and catecholamines, the major stress hormones, inhibit the production of proinflammatory cytokines, such as interleukin (IL)-12, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma, ..
  22. ncbi A comparison of biochemical tests for pheochromocytoma: measurement of fractionated plasma metanephrines compared with the combination of 24-hour urinary metanephrines and catecholamines
    Anna M Sawka
    Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 88:553-8. 2003
    ..of fractionated plasma metanephrine measurements to measurements of 24-h urinary total metanephrines and catecholamines in outpatients tested for pheochromocytoma at Mayo Clinic Rochester from January 1, 1999, until November 27, ..
  23. ncbi Effects of long-term whole-body cold exposures on plasma concentrations of ACTH, beta-endorphin, cortisol, catecholamines and cytokines in healthy females
    J Leppäluoto
    Department of Physiology, University of Oulu, Finland
    Scand J Clin Lab Invest 68:145-53. 2008
    ..Two types of exposure were studied: winter swimming in ice-cold water and whole-body cryotherapy. The outcome was investigated on humoral factors that may account for pain alleviation related to the exposures...
  24. ncbi Activity-dependent differential transmitter release in mouse adrenal chromaffin cells
    Tiberiu Fulop
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106 4970, USA
    J Neurosci 25:7324-32. 2005
    ..When stimulated, they secrete a host of transmitter molecules, including catecholamines and neuropeptides, through the fusion of dense core secretory granules with the cell surface...
  25. ncbi Fos-like immunoreactivity in catecholaminergic brain nuclei after territorial behavior in free-living song sparrows
    Donna L Maney
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurobiol 56:163-70. 2003
    ..The number of flights directed at the intruder was correlated with FLI in AVT but not GCt. These results suggest a role for AVT and GCt, and thus possibly catecholamines, in the regulation of territorial behavior in songbirds.
  26. ncbi The effect of abrupt weaning of suckler calves on the plasma concentrations of cortisol, catecholamines, leukocytes, acute-phase proteins and in vitro interferon-gamma production
    M C Hickey
    Teagasc, Grange Research Centre, Dunsany, Co Meath, Ireland
    J Anim Sci 81:2847-55. 2003
    ..Abrupt weaning increased plasma cortisol and noradrenaline concentrations that were accompanied by attenuation of in vitro interferon-gamma production to novel mitogen and antigen complexes up to 7 d after weaning...
  27. ncbi Interplay between membrane dynamics, diffusion and swelling pressure governs individual vesicular exocytotic events during release of adrenaline by chromaffin cells
    C Amatore
    Ecole Normale Superieure, Departement de Chimie, UMR CNRS 8640 PASTEUR, 24, rue Lhomond, 75231 Cedex 05, Paris, France
    Biochimie 82:481-96. 2000
    ..20000 molecules) should always release through pores. Larger vesicles should always end into fusing except if another mechanism closes the pore before ca. 10000 molecules of catecholamines have been released.
  28. pmc Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion
    Claudia Cavadas
    Center for Neurosciences and Cell Biology and Faculty of Pharmacy, University of Coimbra, 3004 517 Coimbra, Portugal
    Proc Natl Acad Sci U S A 103:10497-502. 2006
    ..We propose that NPY controls the release and synthesis of catecholamine from the adrenal medulla and consequently contributes to the sympathoadrenal tone...
  29. pmc Psychostimulants as cognitive enhancers: the prefrontal cortex, catecholamines, and attention-deficit/hyperactivity disorder
    Craig W Berridge
    Department of Psychology, University of Wisconsin, Madison, WI 53706, USA
    Biol Psychiatry 69:e101-11. 2011
    ..activating doses, psychostimulants produce large and widespread increases in extracellular levels of brain catecholamines. In contrast, cognition-enhancing doses of psychostimulants exert regionally restricted actions, elevating ..
  30. ncbi Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity
    Johan W E Jocken
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Physiol Behav 94:219-30. 2008
  31. ncbi New approach to the simultaneous analysis of catecholamines and tyrosines in biological fluids
    Prem Kumarathasan
    Inhalation Toxicology Section, Safe Environments Programme, Healthy Environments and Consumer Safety Branch, Health Canada, Environmental Health Centre, 0803C Tunney s Pasture, Ottawa, Ontario, Canada K1A 0L2
    J Chromatogr A 987:349-58. 2003
    ..These methods offer sensitivity, specificity, minimal sample requirement, and especially the HPLC-CoulArray method allows simultaneous assessment of various similar biomolecules...
  32. ncbi Catecholamines augment collateral vessel growth and angiogenesis in hindlimb ischemia
    Dan Chalothorn
    Department of Cell and Molecular Physiology, 103 Mason Farm Rd, 6309 MBRB, CB 7545, Univ of North Carolina, Chapel Hill, NC 27599 7545, USA
    Am J Physiol Heart Circ Physiol 289:H947-59. 2005
    ..To further examine this concept, we studied whether catecholamines contribute to collateral growth and angiogenesis in hindlimb insufficiency...
  33. ncbi Desipramine attenuates working memory impairments induced by partial loss of catecholamines in the rat medial prefrontal cortex
    S M Clinton
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
    Psychopharmacology (Berl) 183:404-12. 2006
  34. ncbi Simultaneous determination of catecholamines, uric acid and ascorbic acid at physiological levels using poly(N-methylpyrrole)/Pd-nanoclusters sensor
    Nada F Atta
    Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt
    Anal Biochem 400:78-88. 2010
    ..The reliability and stability of the modified electrode gave a good possibility for applying the technique to routine analysis of AA, DA, and UA in clinical tests...
  35. ncbi Catecholamine stimulation is associated with impaired myocardial O(2) utilization in heart failure
    Lazaros A Nikolaidis
    Department of Medicine, Allegheny General Hospital, MCP Hahneman University School of Medicine, 320 E North Avenue, Pittsburgh, PA 15212, USA
    Cardiovasc Res 53:392-404. 2002
    ..To investigate the effect of alpha,beta(1) and beta(2) adrenergic receptor (AR) stimulation on coronary hemodynamics, myocardial oxygen consumption (M(v)O(2)) and metabolic substrate preference in advanced dilated cardiomyopathy (DCM)...
  36. ncbi Aberrant G-protein coupled receptor expression in relation to adrenocortical overfunction
    Andre Lacroix
    Division of Endocrinology, Department of Medicine, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Universite de Montreal, Montreal, QC, Canada
    Clin Endocrinol (Oxf) 73:1-15. 2010
  37. pmc Sound stress-induced long-term enhancement of mechanical hyperalgesia in rats is maintained by sympathoadrenal catecholamines
    Sachia G Khasar
    Department Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    J Pain 10:1073-7. 2009
  38. ncbi Growth stimulation of intestinal commensal Escherichia coli by catecholamines: a possible contributory factor in trauma-induced sepsis
    Primrose P Freestone
    Department of Microbiology and Immunology, University of Leicester, United Kingdom
    Shock 18:465-70. 2002
    ..Past work has shown that in addition to their ability to function as neurotransmitters, catecholamines can also directly stimulate the growth of a number of pathogenic bacteria...
  39. ncbi Pheochromocytoma: evaluation, diagnosis, and treatment
    M M Walther
    Urologic Oncology Branch, DCS NCI NIH, Bethesda, MD 20892 1501, USA
    World J Urol 17:35-9. 1999
    ..Abdominal imaging and 24-h urine collection for catecholamines are usually be sufficient for diagnosis...
  40. pmc Intracoronary pyruvate in cardiogenic shock as an adjunctive therapy to catecholamines and intra-aortic balloon pump shows beneficial effects on hemodynamics
    Wolfgang Schillinger
    Universitatsmedizin Gottingen, Herzzentrum, Kardiologie und Pneumologie, Robert Koch Str 40, 37099, Gottingen, Germany
    Clin Res Cardiol 100:433-8. 2011
    ..Pyruvate was shown to increase cardiac performance in isolated human and animal myocardium and in patients with chronic heart failure. We sought to investigate the effects of pyruvate in acute heart failure...
  41. ncbi Survey of the adrenal homolog in teleosts
    Valentina Patrizia Gallo
    Department of Animal and Human Biology, University of Rome La Sapienza, I 00185 Rome, Italy
    Int Rev Cytol 230:89-187. 2003
    ..Some of the results are compared to data available from other fishes and vertebrate classes with the aim of including them in an evolutionary and environmental framework...
  42. ncbi Interactive effects of development and hypoxia on catecholamine synthesis and cardiac function in zebrafish (Danio rerio)
    Shelby L Steele
    Department of Biology, University of Ottawa, Gendron Hall, 30 Marie Curie Street, Ottawa, ON, K1N 6N5, Canada
    J Comp Physiol B 181:527-38. 2011
    The rate-limiting enzyme in the biosynthetic pathway of catecholamines is tyrosine hydroxylase (TH), the activity of which is dependent on molecular oxygen. Zebrafish (Danio rerio) possess two non-allelic TH coding genes, TH1 and TH2...
  43. ncbi Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo
    Daniela Sorriento
    Department of Medicine and Surgery, Universita di Salerno, Via Salvador Allende, 84081 Baronissi, Italy
    Hypertension 60:129-36. 2012
    Recently it has been demonstrated that catecholamines are produced and used by macrophages and mediate immune response...
  44. ncbi Comparison of diagnostic accuracy of urinary free metanephrines, vanillyl mandelic Acid, and catecholamines and plasma catecholamines for diagnosis of pheochromocytoma
    James G Boyle
    Division of Cardiovascular and Medical Sciences, Western Infirmary, University of Glasgow, Glasgow G12 8TA, United Kingdom
    J Clin Endocrinol Metab 92:4602-8. 2007
    ..metanephrines with our currently available measurements of 24-h urinary vanillyl mandelic acid (VMA), urinary catecholamines, and plasma catecholamines in 159 outpatients tested in a tertiary referral center for pheochromocytoma over a ..
  45. ncbi Effects of low-sodium diet vs. high-sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride (Cochrane Review)
    Niels A Graudal
    Department of Rheumatology TA4242 Internal Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Am J Hypertens 25:1-15. 2012
    ..The purpose was to estimate the effects of low-sodium vs. high-sodium intake on blood pressure (BP), renin, aldosterone, catecholamines, and lipids.
  46. ncbi Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25
    Gabor Nagy
    Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Neuron 41:417-29. 2004
    ..Overexpression of the SNAP-25b isoform increased the size of both primed vesicle pools by a factor of two, and mutations in the conserved Thr-138 site had similar effects as in the a isoform...
  47. ncbi Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development
    Q Y Zhou
    Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA
    Nature 374:640-3. 1995
    Tyrosine hydroxylase catalyses the initial, rate-limiting step in the catecholamine biosynthetic pathway. Catecholamines, which include dopamine, noradrenaline, and adrenaline, are important neurotransmitters and hormones that regulate ..
  48. ncbi Cardiac dysfunction in cirrhosis - does adrenal function play a role? A hypothesis
    Eleni Theocharidou
    The Royal Free Sheila Sherlock Liver Centre, Royal Free Hospital, Royal Free Hampstead NHS Trust and UCL, London, UK
    Liver Int 32:1327-32. 2012
    ..Thus, AI may play a role in CCM. Steroid replacement therapy reverses cardiac changes in AI, and may do so for CCM, with important therapeutic implications; this needs formal evaluation...
  49. pmc Colocalization of immediate early genes in catecholamine cells after song exposure in female zebra finches (Taeniopygia guttata)
    Kathleen S Lynch
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, USA
    Brain Behav Evol 79:252-60. 2012 catecholamine cells as well as within cells of unknown phenotypes in three brain regions that synthesize catecholamines, the ventral tegmental area, the periaqueductal gray and the locus coeruleus (LoC)...
  50. ncbi A physiological view of the central and peripheral mechanisms that regulate the release of catecholamines at the adrenal medulla
    A M G de Diego
    Instituto Teofilo Hernando, Departamento de Farmacologia y Terapeutica, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
    Acta Physiol (Oxf) 192:287-301. 2008
    ..One or the other catecholamines are differentially released on various stress conditions...
  51. ncbi Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling
    Asaf Spiegel
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Immunol 8:1123-31. 2007
    b>Catecholamines are important regulators of homeostasis, yet their functions in hematopoiesis are poorly understood...
  52. ncbi Oxidation chemistry of catecholamines and neuronal degeneration: an update
    A Napolitano
    Department of Organic Chemistry and Biochemistry, University of Naples Federico II, Naples, Italy
    Curr Med Chem 18:1832-45. 2011
    ..elevated lipid peroxidation, iron accumulation, impaired mitochondrial functioning and antioxidant depletion, catecholamines are oxidatively converted to the corresponding o-quinones, which may initiate a cascade of spontaneous ..
  53. pmc Blockade of catecholamine-induced growth by adrenergic and dopaminergic receptor antagonists in Escherichia coli O157:H7, Salmonella enterica and Yersinia enterocolitica
    Primrose P E Freestone
    Department of Infection, Immunity and Inflammation, University of Leicester School of Medicine, Leicester, UK
    BMC Microbiol 7:8. 2007
    The ability of catecholamines to stimulate bacterial growth was first demonstrated just over a decade ago...
  54. ncbi A test of the catecholamines hypothesis for an acute exercise-cognition interaction
    T McMorris
    University of Chichester, College Lane, Chichester, West Sussex PO19 6PE, UK
    Pharmacol Biochem Behav 89:106-15. 2008
    ..It was concluded that these results provide no support for a direct effect of increased catecholamines concentrations on cognitive performance during exercise...
  55. ncbi The distribution of tyrosine hydroxylase in the canary brain: demonstration of a specific and sexually dimorphic catecholaminergic innervation of the telencephalic song control nulcei
    D Appeltants
    , Center for Research in Cellular and Molecular Neurobiologie, Research Group in Behavioral Neuroendocrinology, Belgium
    Cell Tissue Res 304:237-59. 2001
    ..and female canaries, the distribution of tyrosine hydroxylase (TH), the rate-limiting step in the synthesis of catecholamines. Fibers immunoreactive for TH (TH-ir) were particularly abundant in the lobus parolfactorius, the ..
  56. ncbi The origin of catecholaminergic inputs to the song control nucleus RA in canaries
    Didier Appeltants
    University of Liege, Center for Cellular and Molecular Neurobiology, Research Group in Behavioral Neuroendocrinology, 17 Place Delcour, B 4020, Belgium
    Neuroreport 13:649-53. 2002
    ..These findings and previous work on the high vocal center (HVc) indicate that the two major nuclei of the motor pathway controlling song production (RA and HVc) receive catecholaminergic inputs of similar origins...
  57. ncbi Angiotensin II AT1 receptor blockade prolongs the lifespan of spontaneously hypertensive rats and reduces stress-induced release of catecholamines, glucocorticoids, and vasopressin
    Gustavo Baiardi
    Section on Pharmacology, DIRP, NIMH, NIH, DHHS, 10 Center Drive, Bldg 10, Room 2D 57, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1018:131-6. 2004
    ..The long-term protective effects of AT(1) receptor blockade can be important in animals vulnerable to stress and, in conjunction with the normalization of blood pressure, can prolong lifespan through end-organ protection...
  58. ncbi Brown adipose tissue demonstrating intense FDG uptake in a patient with mediastinal pheochromocytoma
    Ichiei Kuji
    Department of Nuclear Medicine, Saitama International Medical Center, Saitama Medical University, 1397 1 Yamane, Hidaka, Saitama, Japan
    Ann Nucl Med 22:231-5. 2008
    ..The plasma catecholamine concentration and blood pressure then reverted to normal. The FDG uptake in BAT disappeared after tumor resection...
  59. ncbi Sulfonation and molecular action
    Charles A Strott
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    Endocr Rev 23:703-32. 2002
    ..The sulfonation of catecholamines is a prevalent modification that has been extensively studied but, unfortunately, remains poorly understood...
  60. ncbi Evaluation of neurohumoral activation (adrenomedullin, BNP, catecholamines, etc.) in patients with acute myocardial infarction
    Toshiro Katayama
    Department of Cardiovascular Medicine and Course of Medical and Dental Science, Graduate School of Biomedical Science, Nagasaki University, Nagasaki
    Intern Med 43:1015-22. 2004
  61. ncbi Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions
    Amy F T Arnsten
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Biol Psychiatry 57:1377-84. 2005
    ..Most effective treatments for attention-deficit/hyperactivity disorder facilitate catecholamine transmission and likely have their therapeutic actions by optimizing catecholamine actions in prefrontal cortex...
  62. pmc Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles
    D Sulzer
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 97:11869-74. 2000
    ..NM synthesis thus results from excess cytosolic catecholamines not accumulated into synaptic vesicles...
  63. ncbi Effects of cold stress, corticosterone and catecholamines on phagocytosis in mice: differences between resting and activated macrophages
    Gyselle C Baccan
    Departamento de Biofunção, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brasil
    Neuroimmunomodulation 17:379-85. 2010
    ..We subjected mice to acute cold stress and studied the effect on phagocytosis by peritoneal macrophages mediated by 3 types of phagocytic receptors: Fcgamma, complement receptors 3 (CR3) and mannose and beta-glucan receptors...
  64. ncbi Pheochromocytoma: state-of-the-art and future prospects
    Emmanuel L Bravo
    Department of Nephrology and Hypertension, Cleveland Clinic Foundation, Cleveland Ohio 44195, USA
    Endocr Rev 24:539-53. 2003
  65. ncbi Managing chronic pain with encapsulated cell implants releasing catecholamines and endogenous opiods
    Shelley R Winn
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    Front Biosci 10:367-78. 2005
    ..This study demonstrated the safety, retrievability and maintenance of pharmacologically active encapsulated chromaffin cell-loaded devices with human implant dimensions...
  66. ncbi Uptake of mIBG and catecholamines in noradrenaline- and organic cation transporter-expressing cells: potential use of corticosterone for a preferred uptake in neuroblastoma- and pheochromocytoma cells
    Melanie Bayer
    Department of Hematology and Oncology, Children s University Hospital, D 72072 Tuebingen, Germany
    Nucl Med Biol 36:287-94. 2009
    ..In competition, some other cell types are able to take up catecholamines and related compounds probably by organic cation (OCT) [extraneuronal monoamine (EMT)] transporters (OCT1, ..
  67. ncbi Independent influence of insulin, catecholamines, and thyroid hormones on metabolic syndrome
    Giovanni De Pergola
    Internal Medicine, Endocrinology, and Metabolic Disease, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Bari, Italy
    Obesity (Silver Spring) 16:2405-11. 2008
    ..metabolic syndrome, defined according to adult treatment panel III criteria, is associated with insulin, catecholamines, and thyroid hormones, independently of age and gender...
  68. ncbi 5-s-Cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons
    Jeremy P E Spencer
    Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, King s College London
    J Neurochem 81:122-9. 2002
    ..dopamine containing nigral cells in Parkinson's disease may result from the formation of cysteinyl-adducts of catecholamines, which in turn exert toxicity on nigral cells. We show that exposure of neurons (CSM 14...
  69. ncbi The effect of social defeat on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland
    Lin Kooi Ong
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia
    Neurochem Res 36:27-33. 2011
    ..These findings suggest that the regulation of TH phosphorylation in different catecholamine-producing cells varies considerably and is dependent on both the nature of the stressor and the time at which the response is analysed...
  70. ncbi Involvement of corticosteroids and catecholamines in the pathogenesis of central serous chorioretinopathy: a rationale for new treatment strategies
    Lee M Jampol
    Ophthalmology 109:1765-6. 2002
  71. ncbi Quantitative drug levels in stimulant psychosis: relationship to symptom severity, catecholamines and hyperkinesia
    Steven L Batki
    Department of Psychiatry, State University of New York SUNY Upstate Medical University and Syracuse VA Medical Center, Syracuse, NY, USA
    Am J Addict 13:461-70. 2004
    To examine the relationship between quantitative stimulant drug levels, catecholamines, and psychotic symptoms, nineteen patients in a psychiatric emergency service with a diagnosis of amphetamine- or cocaine-induced psychosis were ..
  72. ncbi Renalase, a new secretory enzyme responsible for selective degradation of catecholamines: achievements and unsolved problems
    A E Medvedev
    Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, 119121, Russia
    Biochemistry (Mosc) 75:951-8. 2010
    Renalase is a recently discovered secretory enzyme responsible for selective degradation of blood catecholamines. The review summarizes literature data on expression of this enzyme and on its structure and functions...
  73. pmc The catecholamines up (Catsup) protein of Drosophila melanogaster functions as a negative regulator of tyrosine hydroxylase activity
    D G Stathakis
    Department of Biology, University of Virginia, Charlottesville, Virginia 22903 2477, USA
    Genetics 153:361-82. 1999
    We report the genetic, phenotypic, and biochemical analyses of Catecholamines up (Catsup), a gene that encodes a negative regulator of tyrosine hydroxylase (TH) activity...
  74. ncbi The effects of mind-body training on stress reduction, positive affect, and plasma catecholamines
    Ye Ha Jung
    Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU MRC, Seoul, Republic of Korea
    Neurosci Lett 479:138-42. 2010
    ..Thus, mind-body training may influence stress, positive affect and the sympathetic nervous system including DA activity...
  75. ncbi Cardiovascular regulation after destruction of the C1 cell group of the rostral ventrolateral medulla in rats
    Christopher J Madden
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Am J Physiol Heart Circ Physiol 285:H2734-48. 2003
    ..These data suggest that RVLM-C1 cells contribute to the maintenance of baseline arterial pressure and play an integral role in sympathoexcitatory responses...
  76. pmc Estradiol-dependent modulation of auditory processing and selectivity in songbirds
    Donna L Maney
    Department of Psychology, Emory University, Atlanta, GA, USA
    Front Neuroendocrinol 32:287-302. 2011
  77. pmc Brown adipose tissue in humans is activated by elevated plasma catecholamines levels and is inversely related to central obesity
    Qidi Wang
    Shanghai Key Laboratory for Endocrine Tumors and Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 6:e21006. 2011
    ..The present study is to determine whether BAT activity can be independently stimulated by elevated catecholamines levels in adult human, and whether it is associated with their adiposity.
  78. ncbi Excess nicotinamide inhibits methylation-mediated degradation of catecholamines in normotensives and hypertensives
    Wu Ping Sun
    Department of Physiology, Medical College, Dalian University, Dalian, China
    Hypertens Res 35:180-5. 2012
    Nicotinamide and catecholamines are both degraded by S-adenosylmethionine-dependent methylation. Whether excess nicotinamide affects the degradation of catecholamines is unknown...
  79. ncbi Assessment of continuous positive airway pressure treatment in obstructive sleep apnea syndrome using 24-hour urinary catecholamines
    Mayo Sukegawa
    The Department of Pathophysiological Laboratory Sciences, Nagoya University, Graduate School of Medicine, Japan
    Clin Cardiol 28:519-22. 2005
    ..Obstructive sleep apnea syndrome (OSAS) is related to diurnal sympathetic hyperactivity and increased blood pressure, both factors that are likely to lead to the development of cardiovascular disease...
  80. ncbi Cell-surface actin binds plasminogen and modulates neurotransmitter release from catecholaminergic cells
    Lindsey A Miles
    Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, La Jolla, California, 92037, USA
    J Neurosci 26:13017-24. 2006
    ..Our results suggest that cell-surface-expressed forms of actin bind plasminogen, thereby promoting plasminogen activation and increased prohormone processing leading to inhibition of neurotransmitter release...
  81. ncbi Toxicity of corticosteroids and catecholamines for mice neuronal cell cultures: Role of preservatives
    Carlo Dani
    Department of Surgical and Medical Critical Care, Section of Neonatology, Careggi University Hospital of Florence Florence, Italy
    J Matern Fetal Neonatal Med 20:325-33. 2007
    ..To confirm previous reports on dexamethasone and sulfite neurotoxicity, and to investigate methylprednisolone, dopamine, and dobutamine neurotoxicity...
  82. ncbi Microelectrodes for the measurement of catecholamines in biological systems
    P S Cahill
    Department of Chemistry, University of North Carolina, Chapel Hill 27599 3290, USA
    Anal Chem 68:3180-6. 1996
    ..Also, high-pass filtering discriminated against ascorbic acid, DOPAC, and acidic pH changes, three common interferences in vivo...
  83. pmc Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes
    S Baez
    Unit of Biochemical Toxicology, Department of Biochemistry, Stockholm University, Wallenberg Laboratory, S 106 91 Stockholm
    Biochem J 324:25-8. 1997
    o-Quinones are physiological oxidation products of catecholamines that contribute to redox cycling, toxicity and apoptosis, i.e. the neurodegenerative processes underlying Parkinson's disease and schizophrenia...
  84. ncbi Catecholamines regulate the activity, secretion, and synthesis of renalase
    Guoyong Li
    Department of Medicine, Yale School of Medicine, New Haven, CT 06520 8029, USA
    Circulation 117:1277-82. 2008
    We previously identified renalase, a secreted novel amine oxidase that specifically degrades circulating catecholamines. Parenteral administration of either native or recombinant renalase lowers blood pressure, heart rate, and cardiac ..
  85. ncbi The crosstalks between adipokines and catecholamines
    Aung Than
    Division of Bioengineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore
    Mol Cell Endocrinol 332:261-70. 2011
    ..In the present work, we have studied the interplays between adipokines and catecholamines, using 3T3-L1 adipocytes and PC12 cells as the cell models and an integrative experimental platform...
  86. pmc Catecholaminergic depletion within the prelimbic medial prefrontal cortex enhances latent inhibition
    A J D Nelson
    Schools of Psychology and Biomedical Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    Neuroscience 170:99-106. 2010
    ..6-OHDA lesions to the PL, however, produced potentiation of LI. These results provide the first demonstration that the PL mPFC is a component of the neural circuitry underpinning LI...
  87. ncbi Genome-wide linkage analysis of chromogranin B expression in the CEPH pedigrees: implications for exocytotic sympathochromaffin secretion in humans
    Tiffany A Greenwood
    Department of Medicine, University of California at San Diego, USA
    Physiol Genomics 18:119-27. 2004
    ..Allelic variation in this region may thus influence effects of sympathetic outflow on target organs in humans...
  88. ncbi Human CD4+CD25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop
    Marco Cosentino
    Department of Clinical Medicine, Section of Experimental and Clinical Pharmacology, Center for Research in Neuroscience, University of Insubria, Via Ottorino Rossi n 9, 21100 Varese VA, Italy
    Blood 109:632-42. 2007
    ..14.16.2), the rate-limiting enzyme in the synthesis of catecholamines, and contain substantial amounts of dopamine, norepinephrine, and epinephrine, which are released upon ..
  89. pmc Cardiovascular magnetic resonance and PET-CT of left atrial paraganglioma
    Anderanik Tomasian
    Department of Radiological Sciences, University of California at Los Angeles, USA
    J Cardiovasc Magn Reson 12:1. 2010
  90. ncbi Catecholamines and aggression: the role of COMT and MAO polymorphisms
    Jan Volavka
    Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, New York 10962, USA
    Ann N Y Acad Sci 1036:393-8. 2004 catecholaminergic activity, then the lower activity of COMT and MAOA (resulting in a slower inactivation of catecholamines) should indirectly enhance aggression...
  91. ncbi The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: a primordial carrier for catecholamines
    P Porzgen
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mol Pharmacol 59:83-95. 2001
    ..The identification of a cocaine-sensitive target linked to dopaminergic neurotransmission in D. melanogaster will serve as a basis for further dissection of the genetic components of psychostimulant-mediated behavior...
  92. ncbi Quantal size is dependent on stimulation frequency and calcium entry in calf chromaffin cells
    A Elhamdani
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neuron 31:819-30. 2001
    ..Inhibition of rapid endocytosis damped secretion in successive episodes, implying an essential role for this process in the recycling of vesicles needed for continuous secretion...
  93. ncbi Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction
    Sean W Limesand
    Department of Animal Sciences, University of Arizona, P O Box 210035, Tucson, Arizona 85721 0035, USA
    Endocrinology 147:1488-97. 2006
  94. ncbi Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis
    Larisa Bobrovskaya
    School of Biomedical Sciences and Hunter Medical Research Institute, Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia
    J Neurochem 100:479-89. 2007
    ..Sustained phosphorylation of TH may be a selective target for drugs or pathology in neurons that contain TH and synthesize dopamine, noradrenaline or adrenaline...
  95. ncbi Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia
    S G Priori
    Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy
    Circulation 103:196-200. 2001
  96. ncbi Cigarette smoking may reduce plasma leptin concentration via catecholamines
    Janne E Reseland
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P O Box 1046, Blindern, N 0316 Oslo, Norway
    Prostaglandins Leukot Essent Fatty Acids 73:43-9. 2005
    ..Leptin might influence body weight among smokers...
  97. ncbi Glucose metabolism and catecholamines
    Eberhard Barth
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum, Ulm, Germany
    Crit Care Med 35:S508-18. 2007
    Until now, catecholamines were the drugs of choice to treat hypotension during shock states...
  98. ncbi Catecholamines regulate tumor angiogenesis
    Debanjan Chakroborty
    Department of Pathology, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 69:3727-30. 2009
    ..These reports identify novel endogenous regulators of tumor angiogenesis and also indicate a new and an inexpensive class of antiangiogenic drugs for the treatment of cancer...
  99. pmc Oocytes are a source of catecholamines in the primate ovary: evidence for a cell-cell regulatory loop
    A Mayerhofer
    Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton, OR 97006, USA
    Proc Natl Acad Sci U S A 95:10990-5. 1998
    b>Catecholamines, thought to derive from the extrinsic innervation of the ovary, participate in the regulation of ovarian development and mature gonadal function...
  100. ncbi Efferent projections of rat rostroventrolateral medulla C1 catecholamine neurons: Implications for the central control of cardiovascular regulation
    J Patrick Card
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Comp Neurol 499:840-59. 2006
    ..Collectively, these data demonstrate that RVLM C1 neurons modulate the activity of other central cell groups known to participate in the regulation of cardiovascular and autonomic function...
  101. ncbi Regulation of free radical outflow from an isolated muscle bed in exercising humans
    Damian M Bailey
    Depts of Anesthesiology and Surgery, Colorado Center for Altitude Medicine and Physiology, University of Colorado Health Sciences Center, PO Box 6508, Mail Stop F524, Aurora, CO 80111, USA
    Am J Physiol Heart Circ Physiol 287:H1689-99. 2004

Research Grants67

  1. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..peptide, catestatin (CST), lowers blood pressure (BP) and heart rate (HR) by inhibiting release of catecholamines. Chga, an index member of the chromogranin/secretogranin protein family, is a pro-protein that is ubiquitously ..
  2. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..Secondary outcomes will be plasma levels of catecholamines, free fatty acids, leptin and CRP...
  3. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..Our data will fill in fundamental gaps in our understanding of how brain dopamine systems work. This will help researchers who study these other brain disorders. ..
  4. Misty: a model for central regulation of bone remodeling
    CLIFFORD JAMES ROSEN; Fiscal Year: 2013
    ..In bone, catecholamines bind to [unreadable]2 adrenergic receptors (AR) on osteoblasts to suppress bone formation and increase ..
  5. Role of Subdiaphragmatic Vagus in Fibromyalgia Syndrome
    JON DAVID LEVINE; Fiscal Year: 2013
    ..which developed more than a week after exposure to stress, required concerted action of glucocorticoids and catecholamines at the glucocorticoid and 22-adrenergic receptor, respectively, located in the peripheral terminals of sensory ..
  6. Serotonin transporter-mediated regulation of neuroendocrine exocytosis
    KEVIN P CURRIE; Fiscal Year: 2013
    ..cells are an important neuroendocrine component of the sympathetic nervous system that release a cocktail of catecholamines, peptides, and others transmitters to ensure coordinated physiological responses, for example during the "..
  7. Role of inflammation and cellular stress in the pathogenesis of type 2 diabetes
    Liangyou Rui; Fiscal Year: 2013
    ..g. glucagon and catecholamines);however, potential effects of inflammation on glucagon and catecholamine sensitivity have not been studied...
  8. Respiratory motor control and blood pressure regulation after spinal cord injury
    ..recording of systemic arterial blood pressure, heart rate, cardiac output, and the measurements of blood catecholamines level during orthostatic stress test...
  9. Molecular control of differential peptide transmitter exocytosis.
    COREY B SMITH; Fiscal Year: 2013
    ..Splanchnic activation causes adrenal chromaffin cells to release catecholamines as well as a diverse array of neuro- and vaso-active peptide transmitters into the circulation...
  10. Lipid Metabolism and Steatosis in Liver
    Amrita Kamat; Fiscal Year: 2013
    ..b>Catecholamines acting via beta-adrenergic receptors ( B-ARs) regulate lipid and glucose homeostasis...
  11. The Role of Vascular Innervation on Tissue-type Plasminogen Activator Release
    ..pathway and is released from the vasculature in response to numerous neurohormones including acetylcholine, catecholamines, substance P, arginine vasopressin and bradykinin...
  12. Age and Control of Human Skin Flow
    W Larry Kenney; Fiscal Year: 2013
    ..In adrenergic nerve terminals, BH4 is required for the synthesis and packaging of catecholamines by serving as a critical cofactor for tyrosine hydroxylase and by maintaining the enzyme in its reduced active ..
  13. Microdialysis Studies of Seizure-Induced Oxidative Stress
    Craig E Lunte; Fiscal Year: 2013
    ..of ROS and RNS, biomarkers for DNA damage and lipid peroxidation, and the neurotransmitter amino acids and catecholamines. A new analytical method will be developed to detect prostanoids resulting from arachidonic acid metabolism...
  14. Mechanisms of airborne particulate matter induced thrombosis
    Gokhan M Mutlu; Fiscal Year: 2013
    ..developed 3 specific aims to test the hypothesis that stimulation of the [unreadable]2AR by locally derived catecholamines augments the PM-induced release of IL-6 from alveolar macrophages and the resulting prothrombotic state ..
  15. Impact of Catecholamines to Insulin-Glucose Homeostasis in IUGR Fetuses
    Sean W Limesand; Fiscal Year: 2013
    Impact of Catecholamines to Insulin-Glucose Homeostasis in IUGR Fetuses Endocrine factors such as catecholamines promote fetal survival during intrauterine growth restriction (IUGR) by sparing glucose for critical functions...
  16. Stress-induced hypertension and the role of the neuroimmune system
    PAUL MARVAR; Fiscal Year: 2012
    ..e. elevation of blood pressure, increased catecholamines and corticotropin-releasing hormone (CRH) release...
  17. Ecstasy and the Dorsomedial Hypothalamus
    Daniel E Rusyniak; Fiscal Year: 2010
    ..Identify key brain regions whose activation by MDMA is mediated through the DMH (3) Characterize changes in catecholamines in the DMH resulting from administration of MDMA...
  18. Biological Pathways of Acute and Chronic Stress in Aged Hip Fracture Caregivers
    Lisa Fredman; Fiscal Year: 2012
    ..blood pressure, anthropomorphic measures, and biological markers will be obtained (24-hour urine for catecholamines and cortisol, serum for DHEAS, pro- and anti-inflammatory markers, glucose, cholesterol)...
  19. Exocytosis and Coupled Endocytosis in Neuroendocrine Cells
    JOHN DAVID CASTLE; Fiscal Year: 2010
    ..In adrenal medulla, coupled exocytosis and endocytosis controls secretion of catecholamines, adrenalin and noradrenalin...
  20. CRF and Stress Modulation of Phasic Dopamine Release and Behavior
    MATTHEW J WANAT; Fiscal Year: 2013 independent tenure-track investigator conducting neuroscience research focused on examining the role of catecholamines during behavior...
    Gary V Desir; Fiscal Year: 2010
    ..The renalase pathway is a previously unrecognized mechanism for regulating circulating catecholamines, and, therefore, cardiac function, and blood pressure...
  22. Attenuation of cardiac parasympathetic nerve acetylcholine release in obesity by
    Wohaib Hasan; Fiscal Year: 2012
    ..In addition, increased heart rate and plasma catecholamines, and reduced heart rate variability in obesity are due to altered cardiac autonomic control including ..
    Janet King; Fiscal Year: 2009
    ..human chorionic somatomammotropin, progesterone, leptin, adiponectin, prolactin, glucagon, cortisol, catecholamines, and ghrelin);and 3) to determine if consuming low GL diets the last half of pregnancy reduces the prevalence ..
  24. MBSR Symptom Cluster Trial for Breast Cancer Survivors
    Cecile A Lengacher; Fiscal Year: 2013
    ..immune cytokines, cellular adhesion molecules, lymphocyte subsets) and stress-related hormones (cortisol, catecholamines)...
  25. Tumor metastasis: Biobehavioral mechanisms
    Anil K Sood; Fiscal Year: 2009
    ..During this work, we have made novel observations that chronic stress and associated increases in catecholamines protect tumor cells from undergoing anoikis, but the exact mechanisms are not well known...
  26. Recognition of host catecholamines in Borrelia burgdorferi gene regulation
    Linden T Hu; Fiscal Year: 2010
    ..In this proposal, we describe our plans to understand how the recognition of host catecholamines affects bacterial processes...
  27. Persistent COMT-dependent Pain: Role of beta-adrenergic Receptors
    ANDREA G NACKLEY NEELY; Fiscal Year: 2013
    ..due, in large part, to diminished activity of catechol-O- methyltransferase (COMT;an enzyme that metabolizes catecholamines), which results in elevated levels of catecholamines and increased activity of beta2/3-adrenergic receptors (..
  28. Right Heart Function in Health and Chronic Lung Disease
    Anthony J Baker; Fiscal Year: 2013
    ..These studies will be significant for understanding and treating human disease. In heart failure, where catecholamines are elevated, upregulation of RV inotropic responses might help the RV adapt to increased pulmonary pressures...
  29. Alpha-1A-adrenergic agonist therapy for cardiomyopathy and heart failure
    Paul C Simpson; Fiscal Year: 2013
    ..The catecholamines norepinephrine (NE) and epinephrine (EPI) activate two types of ARs on cardiac muscle cells, the dominant beta-..
  30. Chemical Anatomy and Synaptology of Vestibulo-Sympathetic Pathways
    Gay R Holstein; Fiscal Year: 2013 likely to be glutamate, numerous neuroactive molecules have been co-localized in these cells, including catecholamines of the C1 cell group...
  31. Immunity, Inflammation and Hypertension
    David G Harrison; Fiscal Year: 2013
    ..We have previously shown that various hypertensive stimuli, including angiotensin II, high salt and catecholamines cause T cell activation and entry of T cells with an effector phenotype into the vasculature and the kidney...
  32. Mechanisms underlying adverse health consequences of shift work
    Frank A Scheer; Fiscal Year: 2013
    ..markers (CRP, IL-6, TNF-alpha, MCP-1), peripheral vascular endothelial function, and autonomic control (catecholamines, sympatho-vagal balance, baroreceptor sensitivity and systemic blood pressure)...
  33. Genetic components influencing the feline - human social bond
    Leslie A Lyons; Fiscal Year: 2011
    ..affecting monoamine neurotransmitter pathway genes, which encode enzymes that metabolize serotonin and the catecholamines, are under investigation in a host of human and animal studies to understand the genetic components of ..
  34. Mindfulness Based Stress Reduction for Psycho-Immune Dysregulation in Cancer
    Herbert L Mathews; Fiscal Year: 2012
    ..Assessments of immune function (NKCA and cytokines), neuroendocrine activity (salivary cortisol and plasma catecholamines), psychosocial response, and HRQL will be obtained pre-, mid-, at completion, and post-MBSR...
  35. Does doxazosin attenuate stress-induced smoking and improve clinical outcomes?
    SHERRY ANN MCKEE; Fiscal Year: 2012
    ..g., craving, mood, cardiovascular reactivity, HPA axis reactivity, catecholamines) and explore additional mechanisms hypothesized to underlie noradrenergic effects on smoking behavior (e.g...
  36. Anchored Kinase Signaling Mechanisms in Cardiac Hypertrophy
    John D Scott; Fiscal Year: 2012
    ..At the molecular level, hypertrophic signals such as elevated catecholamines evoke transcriptional activation of the Myocyte Enhancer Factor (MEF2) pathway to change the pattern of ..
  37. Regulation of Lung Inflammation by Catecholamines and Adrenergic Receptors
    Peter A Ward; Fiscal Year: 2013
    ..The proposed work will relate to our recent discoveries that the adrenergic nervous system plays an important role in acute lung inflammation and can be manipulated for therapeutic benefit. ..
  38. Identifying brain mediators distinguishing eustress and distress impact on cancer
    Lei Cao; Fiscal Year: 2013
    ..However, both EE and SI increase the classical stress hormones, glucocorticoids and catecholamines, and ss-adrenergic blockers may abrogate their effects on cancer...
    ROBERT MARK WIGHTMAN; Fiscal Year: 2012
    ..Amperometry at a carbon-fiber microelectrode (with an applied potential sufficient to oxidize catecholamines) placed next to an isolated secretory cell can follow exocytosis as a series of current spikes composed of ..
  40. Estrogen-Derived Para-Quinol Intervention in Alzheimer's Disease
    Mary A Ottinger; Fiscal Year: 2010
    ..will be collected to monitor the progression of the neurodegenerative disease, including behavioral testing, catecholamines, markers of AD neuropathology, and markers of brain inflammation in females...
    Gary V Desir; Fiscal Year: 2010
    ..Renalase is an amine oxidase that metabolizes catecholamines such as dopamine, epinephrine and norepinephrine...
  42. Effect of Insulin and Propranolol on Post Burn Hypermetabolism and Inflammation
    David N Herndon; Fiscal Year: 2012
    ..with a persistent and sustained hypermetabolic response characterized by elevated levels of circulating catecholamines, cytokines and cortisol, which cause muscle wasting, immunodeficiency, organ dysfunction and a delay in wound ..
  43. The Role of the Sympathetic Nervous System in Major Depression and Inflammation
    ANDREA INES LIATIS; Fiscal Year: 2010
    ..have shown that stress-induced increases in inflammatory responses are mediated in part through the release of catecholamines and stimulation of alpha-1 adrenergic receptor subtypes...
  44. Adolescent alcohol exposure and altered adult HPA axis activity
    SOON O LEE; Fiscal Year: 2013
    ..released by alcohol in the brain, to activate the HPA axis, is also altered by AIE;and that the role played by catecholamines in modulating the consequences of AIE might be sexually dimorphic...
  45. Sleep Apnea in TIA: Reducing Cardiovascular Risk with Positive Airway Pressure
    Henry Klar Yaggi; Fiscal Year: 2012
    ..risk including: inflammation (CRP, Il-6), heightened sympathetic activity/parasympathetic withdrawal (plasma catecholamines and heart rate variability (HRV)), insulin resistance (HOMA-IR, HbA1C), endothelial injury (flow mediated ..
  46. Mitigation of the Catecholamine Surge in Severely Burned Patients
    David N Herndon; Fiscal Year: 2013
    ..Endogenous catecholamines have been implicated as primary mediators of the hypermetabolic response to trauma or burn...
  47. BNP and Neuroimmune Characteristics of CHF &Depression
    Paul J Mills; Fiscal Year: 2013
    ..will include circulating levels of BNP, CRP, TNF-[unreadable], IL-1[unreadable], IL-6, sICAM-1, sP-selectin, catecholamines, and functional assessments of leukocytes...
    Charles N Falany; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sulfation is a major conjugation reaction for many endogenous sterols, catecholamines, bile acids and thyroid hormones as well as xenobiotics and therapeutic drugs...
  49. Cross-talk with the Insulin Receptor Attenuates Adrenergic Function within the He
    David Cervantes; Fiscal Year: 2013
    ..The lack of CAD and hypertension in DCM, even in the presence of elevated catecholamines, suggests that hyperinsulinemia elicits direct cardiomyocyte insult, possibly by modulating adrenergic ..
  50. Effect of COMT genetic polymorphism on response to propranolol therapy in TMD
    ..evidence suggests that diminished activity of catechol-O-methyltransferase (COMT;an enzyme that metabolizes catecholamines), which results in elevated levels of catecholamines and increased activity of [unreadable]2/3-adrenergic ..
  51. Integration of Peripheral and Central Appetite Signals by Brainstem Neurons
    Suzanne M Appleyard; Fiscal Year: 2013
    ..Ablation of NTS neurons expressing catecholamines (NTS-CA neurons) disrupts control of food intake by several hormones, including ghrelin and cholecystokinin (..
    RICHARD NATHAN BERGMAN; Fiscal Year: 2013
    ..sleep, lipolysis (measured using plasma FFA and tracer dilution methods) and neurally active agents, including catecholamines and leptin, will be assessed over 24 hr periods with hourly sampling. II...
  53. Reactivity and Kinetic Properties of TbetaMu Site-Specific Mutants
    ROBERT LYLE OSBORNE; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Dicopper monooxygenases are critical for the biogenesis of catecholamines, and the mechanism by which such enzymes regulate the coupling of C-H and oxygen activation remains unclear...
  54. Novel therapy for cardiotoxicity of cancer drugs
    Paul C Simpson; Fiscal Year: 2013
    ..Alpha-1- ARs, along with beta-ARs and alpha-2-ARs, are G-protein-coupled receptors for the catecholamines norepinephrine and epinephrine. Alpha-1-ARs exist as three molecular subtypes, named A, B, and D...
  55. Regulation of Cytosolic Dopamine by Ca2+ in Ventral Midbrain Neurons
    Eugene V Mosharov; Fiscal Year: 2010
    ..patch electrochemistry (IPE), a technique that directly measures cellular concentrations of cytosolic catecholamines. We have now adapted this approach for measuring cytosolic DA in cultured VM neurons...
  56. Molecular Regulation of Cardiovascular 7 TM Receptors
    Robert J Lefkowitz; Fiscal Year: 2013
    ..The largest of all the receptor families, it includes receptors for catecholamines, acetylcholine, angiotensin, adenosine and endothelins...
  57. Beta Adrenoceptor Signaling Complexes in Innervated Cardiac Myocytes
    Brian K Kobilka; Fiscal Year: 2012
    ..These receptors are essential for the physiologic regulation of cardiac function in response to catecholamines (adrenaline and noradrenaline) released from sympathetic nerves...
  58. Steroid-catecholamine-brain interactions in auditory-driven social behavior
    Paul M Forlano; Fiscal Year: 2013
    ..The objective of this proposal is to discover how steroid hormones interact with catecholamines in circuits important for normal auditory-driven social behavioral interactions...
  59. Nanoparticle scavengers for in vivo sequestration of overdosed drug molecules
    Zhiguo Zhou; Fiscal Year: 2013
    ..General rescue therapies such as cardiopulmonary resuscitation, intravenous catecholamines to support homeostasis are used to treat drug intoxications in emergency room...
    Curt Freed; Fiscal Year: 1991
    Serotonin and the catecholamines are known to play a role in the regulation of blood pressure. Serotonin agonists, alpha-2 receptor agonists and dopamine agonists have all been shown to lower blood in hypertensive animals...
  61. Impact of Ghrelin of Beta-cell Function and Insulin Sensitivity in Humans
    Jenny Tong; Fiscal Year: 2011 peripheral insulin sensitivity or from changes in counter-regulatory hormones (growth hormone [GH], catecholamines, and cortisol). Specific Aim 1: To determine the dose of ghrelin required to inhibit insulin secretion...
  62. 2013 Catecholamines Gordon Research Conference and Gordon Research Seminar
    Paul E M Phillips; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The 2013 GRC/GRS Seminar on Catecholamines will take place at Mount Snow Resort, in West Dover, Vermont. August 10 - 16, 2013...
  63. "Innate intestinal responses in murine toxoplasmosis"
    Fernando Monroy; Fiscal Year: 2005
    ..system leading to the release of glucocorticoids (corticosterone) from the adrenal cortex, and release of catecholamines (epinephrine, nor-epinephrine) from sympathetic nerve terminals and the adrenal medulla...
    James Douglas; Fiscal Year: 1993
    ..maturational changes are closely related to increased levels of plasma hydrocortisone and altered circulating catecholamines concentrations...
    Kandatege Wimalasena; Fiscal Year: 2003
    Easily autooxidizable catecholamines are known to generate reactive radicals and H2O2 under aerobic conditions due to their inherent redox properties...
    Laurence Becker; Fiscal Year: 1991
    ..concerned with control of respiration (brain stem, vagus nerve) and more recently found elevated levels of catecholamines (CA), mainly dopamine in carotid bodies (CB) of SIDS infants...
    CHARLES PILATI; Fiscal Year: 1993
    ..The underlying hypothesis of this proposal is the intense SNS activity produces cardiotoxic concentrations of catecholamines that diminish LV function by causing myocyte Ca++ overload and/or by producing large increases in LV afterload...