milrinone

Summary

Summary: A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the ionotropic potency of amrinone.

Top Publications

  1. ncbi Intravenous milrinone in cardiac surgery
    Jerrold H Levy
    Division of Cardiothoracic Anesthesiology and Critical Care, Emory University School of Medicine and Emory Healthcare, Atlanta, Georgia, USA
    Ann Thorac Surg 73:325-30. 2002
  2. ncbi Milrinone for the treatment of cerebral vasospasm after subarachnoid hemorrhage: report of seven cases
    Y Arakawa
    Department of Neurosurgery, Kurashiki Central Hospital, Okayama, Japan
    Neurosurgery 48:723-8; discussion 728-30. 2001
  3. ncbi Milrinone therapy for enterovirus 71-induced pulmonary edema and/or neurogenic shock in children: a randomized controlled trial
    Chia Yu Chi
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan
    Crit Care Med 41:1754-60. 2013
  4. ncbi Milrinone and nitric oxide: combined effect on pulmonary artery pressures after cardiopulmonary bypass in children
    Vadim Khazin
    Department of Anesthesia, The Edith Wolfson Medical Center, Affiliated with Sackler School of Medicine, Holon, Israel
    J Cardiothorac Vasc Anesth 18:156-9. 2004
  5. ncbi Intra-arterial milrinone for reversible cerebral vasoconstriction syndrome
    Manon Bouchard
    Department of Neurological Sciences, CHA Enfant Jésus, Faculty of Medicine, Laval University, Quebec City, QC, Canada
    Headache 49:142-5. 2009
  6. ncbi Therapeutic efficacy of milrinone in the management of enterovirus 71-induced pulmonary edema
    Shih Min Wang
    Department of Emergency Medicine, College of Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan
    Pediatr Pulmonol 39:219-23. 2005
  7. ncbi Levosimendan or milrinone in the type 2 diabetic patient with low ejection fraction undergoing elective coronary artery surgery
    Emad Al-Shawaf
    Department of Anesthesia, The Chest Diseases Hospital, Ministry of Health, Safat, Kuwait
    J Cardiothorac Vasc Anesth 20:353-7. 2006
  8. pmc Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn
    Satyan Lakshminrusimha
    Department of Pediatrics, University of Buffalo, Buffalo, NY, USA
    Pediatr Crit Care Med 10:106-12. 2009
  9. ncbi Effects of milrinone on left ventricular end-systolic pressure-volume relationship of rat hearts in situ
    T Kishi
    Department of Physiology II, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan
    Clin Exp Pharmacol Physiol 28:737-42. 2001
  10. ncbi Effects of dopamine, dobutamine, amrinone and milrinone on regional blood flow in isoflurane anesthetized dogs
    Denji Tobata
    Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Vet Med Sci 66:1097-105. 2004

Research Grants

  1. MYOCARDIAL ENERGY METABOLISM IN THE DYSFUNCTIONAL LV
    Jianyi Zhang; Fiscal Year: 2003
  2. ACUTE BRAIN INJURY AFTER SUBARACHNOID HEMORRHAGE
    Joshua Bederson; Fiscal Year: 2001
  3. PHARMACOLOGY OF DEVELOPING CARDIAC TISSUES
    Achilles Pappano; Fiscal Year: 2000
  4. Regulation of Mammalian Oocyte Maturation
    Stephen Downs; Fiscal Year: 2007
  5. Decision Making in End-Stage Heart Failure
    Paul Hauptman; Fiscal Year: 2006
  6. CYCLIC AMP/ADENOSINE PATHWAY
    Edwin Jackson; Fiscal Year: 2002
  7. Engineering a CFTR Deficient Porcine Model of CF
    SCOTT O GRADY; Fiscal Year: 2007
  8. Molecular Control of cGMP Signaling by PKGs and PDEs
    Jackie Corbin; Fiscal Year: 2007
  9. Molecular Mechanisms of PDE5 Regulation
    Jackie Corbin; Fiscal Year: 2005
  10. PKC-EHN-PKD signal complex in cardiac remodeling
    Masahiko Hoshijima; Fiscal Year: 2009

Detail Information

Publications216 found, 100 shown here

  1. ncbi Intravenous milrinone in cardiac surgery
    Jerrold H Levy
    Division of Cardiothoracic Anesthesiology and Critical Care, Emory University School of Medicine and Emory Healthcare, Atlanta, Georgia, USA
    Ann Thorac Surg 73:325-30. 2002
    Phosphodiesterase inhibitors including milrinone produce positive inotropic effects by slowing the hydrolysis of cyclic adenosine monophosphate in the myocardium. With a loading dose of 50 microg/kg followed by an infusion of 0...
  2. ncbi Milrinone for the treatment of cerebral vasospasm after subarachnoid hemorrhage: report of seven cases
    Y Arakawa
    Department of Neurosurgery, Kurashiki Central Hospital, Okayama, Japan
    Neurosurgery 48:723-8; discussion 728-30. 2001
    ..b>Milrinone is an inotropic drug that dilates vessels by phosphodiesterase inhibition in a mechanism similar to that of ..
  3. ncbi Milrinone therapy for enterovirus 71-induced pulmonary edema and/or neurogenic shock in children: a randomized controlled trial
    Chia Yu Chi
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan
    Crit Care Med 41:1754-60. 2013
    ..In a small pilot study, we found that milrinone reduced early mortality compared with historical controls...
  4. ncbi Milrinone and nitric oxide: combined effect on pulmonary artery pressures after cardiopulmonary bypass in children
    Vadim Khazin
    Department of Anesthesia, The Edith Wolfson Medical Center, Affiliated with Sackler School of Medicine, Holon, Israel
    J Cardiothorac Vasc Anesth 18:156-9. 2004
    To investigate the effect of milrinone combined with nitric oxide (NO) on the pulmonary artery pressures (PAP) after cardiopulmonary bypass (CPB), for repair of congenital heart defects (CHD) in children.
  5. ncbi Intra-arterial milrinone for reversible cerebral vasoconstriction syndrome
    Manon Bouchard
    Department of Neurological Sciences, CHA Enfant Jésus, Faculty of Medicine, Laval University, Quebec City, QC, Canada
    Headache 49:142-5. 2009
    ..Within hours of neurological deterioration, she was treated with intra-arterial milrinone, a phosphodiesterase inhibitor, which resulted in a rapid and sustained neurological improvement.
  6. ncbi Therapeutic efficacy of milrinone in the management of enterovirus 71-induced pulmonary edema
    Shih Min Wang
    Department of Emergency Medicine, College of Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan
    Pediatr Pulmonol 39:219-23. 2005
    ..This study was designed to evaluate the potential therapeutic effect of milrinone, a phosphodiesterase (PDE) inhibitor, in the treatment of patients with EV71-induced pulmonary edema...
  7. ncbi Levosimendan or milrinone in the type 2 diabetic patient with low ejection fraction undergoing elective coronary artery surgery
    Emad Al-Shawaf
    Department of Anesthesia, The Chest Diseases Hospital, Ministry of Health, Safat, Kuwait
    J Cardiothorac Vasc Anesth 20:353-7. 2006
    ..in 2 groups of type 2 diabetic patients with depressed myocardial function who underwent elective surgery for coronary artery disease and who received levosimendan or milrinone for postcardiopulmonary bypass low-output syndrome.
  8. pmc Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn
    Satyan Lakshminrusimha
    Department of Pediatrics, University of Buffalo, Buffalo, NY, USA
    Pediatr Crit Care Med 10:106-12. 2009
    ..Forskolin is a direct stimulant of AC. Phosphodiesterase 3 hydrolyzes cAMP and is inhibited by milrinone.
  9. ncbi Effects of milrinone on left ventricular end-systolic pressure-volume relationship of rat hearts in situ
    T Kishi
    Department of Physiology II, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan
    Clin Exp Pharmacol Physiol 28:737-42. 2001
    ..b>Milrinone is a non-glycosidic, non-sympathomimetic drug that increases myocardial cAMP concentrations by selective ..
  10. ncbi Effects of dopamine, dobutamine, amrinone and milrinone on regional blood flow in isoflurane anesthetized dogs
    Denji Tobata
    Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Vet Med Sci 66:1097-105. 2004
    The effects of cyclic AMP increasing cardiotonics (dopamine, dobutamine, amrinone and milrinone) on the blood flow in most organs were compared using colored microsphere technique in isoflurane-anesthetized dogs...
  11. pmc Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure
    David E Lanfear
    Department of Internal Medicine, Division of Cardiology, Henry Ford Hospital, Detroit, Michigan, USA
    J Transl Med 7:67. 2009
    ..Whether biomarkers of myocardial necrosis, inflammation and apoptosis change in response to acute milrinone administration is not well established.
  12. ncbi Effects of single administration of a phosphodiesterase III inhibitor during cardiopulmonary bypass: comparison of milrinone and amrinone
    Y Hamada
    Department of Surgery II, Ehime University School of Medicine, Japan
    Jpn Circ J 63:605-9. 1999
    ..Ten patients (group M) were administered milrinone (50 microg/kg) after aortic declamping during CPB, 10 patients were administered amrinone (1 mg/kg) at the same ..
  13. ncbi Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure
    Thomas Hentschel
    Department of Anesthesiology, German Heart Institute Berlin, Institute of Physiology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Germany
    Anesthesiology 106:124-31. 2007
    ..of a vasodilatory phosphodiesterase-3 inhibitor may reverse this potentially detrimental process, the authors studied the effects of inhaled or intravenous milrinone on pulmonary and systemic hemodynamics in a rat model of CHF.
  14. ncbi Levosimendan is superior to milrinone and dobutamine in selectively increasing microvascular gastric mucosal oxygenation in dogs
    Lothar A Schwarte
    Department of Anesthesiology, University Hospital of Dusseldorf, Germany
    Crit Care Med 33:135-42; discussion 246-7. 2005
    ..We compared systemic and regional effects of levosimendan with those of established inotropes, milrinone and dobutamine.
  15. ncbi Milrinone, dobutamine or epinephrine use in asphyxiated newborn pigs resuscitated with 100% oxygen
    Chloe Joynt
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
    Intensive Care Med 36:1058-66. 2010
    ..In a swine model of neonatal hypoxia-reoxygenation, effects of epinephrine, dobutamine and milrinone on systemic, pulmonary and regional hemodynamics and oxygen transport were compared.
  16. ncbi Low-dose β-blocker in combination with milrinone safely improves cardiac function and eliminates pulsus alternans in patients with acute decompensated heart failure
    Shigeki Kobayashi
    Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Circ J 76:1646-53. 2012
    The purpose of this study was to determine whether a low-dose β-blocker, in combination with milrinone, improves cardiac function in acute decompensated heart failure (ADHF) with tachycardia.
  17. ncbi Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease
    Timothy M Hoffman
    Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Circulation 107:996-1002. 2003
    ..This study evaluated the efficacy and safety of prophylactic milrinone in pediatric patients at high risk for developing LCOS.
  18. ncbi Milrinone modulates endotoxemia, systemic inflammation, and subsequent acute phase response after cardiopulmonary bypass (CPB)
    T Mollhoff
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Westfälische Westfälische Wilhelms Universität Münster, Germany
    Anesthesiology 90:72-80. 1999
    ..The authors evaluated the effects of milrinone on splanchnic oxygenation, systemic inflammation, and the subsequent acute-phase response in patients undergoing ..
  19. ncbi Milrinone and low cardiac output following cardiac surgery in infants: is there a direct myocardial effect?
    B Duggal
    Paediatric Intensive Care Unit, Royal Brompton and Harefield NHS Trust, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Pediatr Cardiol 26:642-5. 2005
    We assessed the effect of milrinone on myocardial function in pediatric patients with postoperative low cardiac output syndrome by index of myocardial performance in a prospective, open-label, nonrandomized, consecutive study...
  20. ncbi Pharmacokinetics and side effects of milrinone in infants and children after open heart surgery
    C Ramamoorthy
    Department of Anesthesiology, University of Washington School of Medicine, Seattle, USA
    Anesth Analg 86:283-9. 1998
    We investigated the pharmacokinetics and side effects of milrinone in infants and children (< or = 13 yr) after open heart surgery in this prospective, open-label study...
  21. ncbi Milrinone efficiently potentiates insulin secretion induced by orally but not intravenously administered glucose in C57BL6J mice
    Eva Degerman
    Department of Cell and Molecular Biology, Biomedical Center, C11, 22184 Lund, Sweden
    Eur J Pharmacol 498:319-23. 2004
    ..of phosphodiesterase (PDE) 3 inhibition on plasma insulin and glucose levels, the selective PDE 3 inhibitor milrinone (0.25, 1.0, and 2...
  22. ncbi The effect of milrinone on platelet activation as determined by TEG platelet mapping
    Mark C Wesley
    Department of Anesthesia, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 108:1425-9. 2009
    b>Milrinone is a phosphodiesterase III inhibitor that increases intracellular cyclic adenosine monophosphate resulting in improved ventricular function and vasodilation...
  23. ncbi Administration of milrinone before ischemia, in the presence of beta-blockade, to treat metabolic impairment and myocardial stunning in pigs
    A Sidi
    Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, USA
    Acta Anaesthesiol Scand 52:397-405. 2008
    ..We examined effects of phosphodiesterase type III inhibition on regional myocardial metabolism and global left ventricular function, during ischemia, in the presence of beta-blockade...
  24. ncbi Anti-ischemic effects of inotropic agents in experimental right ventricular infarction
    M Hein
    Department of Anesthesiology, University Hospital of Aachen, Aachen, Germany
    Acta Anaesthesiol Scand 53:941-8. 2009
    ..Therefore, we used a porcine model of RV ischemia and reperfusion (IR) injury to study the influence of milrinone, levosimendan and dobutamine on the extent and degree of myocardial injury.
  25. ncbi Nitric oxide and milrinone: combined effect on pulmonary circulation after Fontan-type procedure: a prospective, randomized study
    Jiming Cai
    Department of Cardiovascular and Thoracic Surgery, Shanghai Children s Medical Center, Shanghai Jiao Tong University School of Medicine formerly Shanghai Second Medical University, Shanghai, China
    Ann Thorac Surg 86:882-8; discussion 882-8. 2008
    ..Inhalation of nitric oxide (iNO) and intravenous milrinone are two options capable of reducing pulmonary vascular resistance...
  26. ncbi Combined usage of inhaled and intravenous milrinone in pulmonary hypertension after heart valve surgery
    Mladen Carev
    Department of Anesthesiology and Intensive Care, Split University Hospital Center, Split, Croatia
    Coll Antropol 34:1113-7. 2010
    ..The usage of inhaled milrinone could be the possible therapeutic option...
  27. ncbi Effects of a new phosphodiesterase enzyme type V inhibitor (UK 343-664) versus milrinone in a porcine model of acute pulmonary hypertension
    Felipe Urdaneta
    Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida 32610 0254, USA
    Ann Thorac Surg 78:1433-7. 2004
    ..Perioperative pulmonary hypertension remains a clinical challenge. The phosphodiesterase enzyme type III inhibitor milrinone produces pulmonary vasodilation but lacks selectivity...
  28. ncbi Comparison of the effects of cilostazol and milrinone on cAMP-PDE activity, intracellular cAMP and calcium in the heart
    Yasmin Shakur
    Otsuka Maryland Research Institute, 9900 Medical Center Drive, Rockville, MD 20850, USA
    Cardiovasc Drugs Ther 16:417-27. 2002
    We investigated the basis for the difference in the cardiotonic effects of the PDE3 inhibitors cilostazol and milrinone in the rabbit heart...
  29. ncbi Intestinal hemodynamic effects of milrinone in asphyxiated newborn pigs after reoxygenation with 100% oxygen: a dose-response study
    Chloe Joynt
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Shock 31:292-9. 2009
    Neonatal asphyxia can result in poor perfusion, vasoconstriction, and decreased oxygen delivery in the intestine. Milrinone increases myocardial contractility and causes peripheral vasodilatation...
  30. ncbi Effect of milrinone on short-term outcome of patients with myocardial dysfunction undergoing coronary artery bypass graft: A randomized controlled trial
    Mohammad Jebeli
    Cardiac Surgery Department, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran
    Cardiol J 17:73-8. 2010
    ..In this study, we evaluate the effect of milrinone on patients with ventricular dysfunction undergoing coronary artery bypass graft (CABG).
  31. pmc Heart protection by combination therapy with esmolol and milrinone at late-ischemia and early reperfusion
    Ming He Huang
    Department of Internal Medicine, Cardiology Division M HH, YW, VN, SR, BFU, KF, University of Texas Medical Branch, Galveston, TX, USA
    Cardiovasc Drugs Ther 25:223-32. 2011
    The present study determined whether late-ischemia/early reperfusion therapy with the β(1)-adrenergic receptor (AR) blocker esmolol and phosphodiesterase III inhibitor milrinone reduced left ventricular (LV) myocardial infarct size (IS).
  32. ncbi Milrinone facilitates resuscitation from cardiac arrest and attenuates postresuscitation myocardial dysfunction
    James T Niemann
    Harbor UCLA Medical Center, Department of Emergency Medicine and the David Geffen UCLA School of Medicine, Los Angeles, Calif, USA
    Circulation 108:3031-5. 2003
    ..The purpose of this study was to investigate the use of milrinone, a selective phosphodiesterase III inhibitor, as treatment for LV dysfunction after resuscitation.
  33. ncbi Milrinone combined with vasopressin improves cardiac index after cardiopulmonary resuscitation in a pig model of myocardial infarction
    Thomas Palmaers
    Department of Anesthesiology, University Hospital Erlangen, Germany
    Anesthesiology 106:100-6. 2007
    b>Milrinone used for acute cardiac insufficiency could be of interest during cardiopulmonary resuscitation because of its positive inotropic effects...
  34. ncbi Hemodynamic changes during off-pump coronary artery bypass anastomosis in patients with coexisting mitral regurgitation: improvement with milrinone
    Takeshi Omae
    Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Kagoshima University, Sakuragaoka, Japan
    Anesth Analg 101:2-8, table of contents. 2005
    ..increased in patients with coexisting MR during off-pump coronary artery bypass (OPCAB) anastomosis, and that milrinone could ameliorate increases in MR that occur during OPCAB anastomosis...
  35. pmc Intravenous milrinone in treatment of advanced congestive heart failure
    Aly M Zewail
    Departments of Transplantation and Heart Failure, Texas Heart Institute and St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    Tex Heart Inst J 30:109-13. 2003
    Phosphodiesterase inhibitors such as milrinone can relieve symptoms and improve hemodynamics in patients with advanced congestive heart failure...
  36. ncbi Milrinone, a selective phosphodiesterase 3 inhibitor, stimulates lipolysis, endogenous glucose production, and insulin secretion
    Peter Cheung
    Division of Endocrinology Diabetes Metabolism, Clinical Research Center, Temple University School of Medicine, Philadelphia, PA 19141, USA
    Metabolism 52:1496-500. 2003
    In vivo effects of milrinone, a selective phosphodiesterase 3 (PDE-3) inhibitor, on plasma free fatty acids (FFA), glucose, and insulin levels were examined in alert rats...
  37. ncbi Levosimendan restores both systolic and diastolic cardiac performance in lipopolysaccharide-treated rabbits: comparison with dobutamine and milrinone
    Damien Barraud
    Equipe d Accueil 322, Universite, Paris, France
    Crit Care Med 35:1376-82. 2007
    ..Our study aimed to fully characterize both systolic and diastolic abnormalities of sepsis-associated heart failure and to identify treatment that would support full-cycle cardiac improvement...
  38. ncbi Randomized trial of milrinone versus placebo for prevention of low systemic blood flow in very preterm infants
    Mary Paradisis
    Department of Neonatal Medicine, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    J Pediatr 154:189-95. 2009
    To assess the effectiveness of early prophylactic milrinone versus placebo for prevention of low systemic blood flow in high-risk preterm infants.
  39. ncbi Effect of milrinone on left ventricular relaxation and Ca(2+) uptake function of cardiac sarcoplasmic reticulum
    M Yano
    Second Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Am J Physiol Heart Circ Physiol 279:H1898-905. 2000
    b>Milrinone, a phosphodiesterase 3 (PDE3) inhibitor, is known to enhance left ventricular (LV) contractility by an inhibition of the breakdown of cAMP through the mechanism inhibiting PDE3...
  40. ncbi Effect of levosimendan and milrinone on regional myocardial ischemia/reperfusion-induced arrhythmias in dogs
    Julius Gy Papp
    Department of Pharmacology and Pharmacotherapy, Albert Szent Gyorgyi Medical Center, University of Szeged, Szeged, Hungary
    J Cardiovasc Pharmacol Ther 11:129-35. 2006
    ..The effect of levosimendan, a calcium sensitizer, and milrinone, a phosphodiesterase inhibitor, on ventricular arrhythmias was compared in a model of acute regional myocardial ..
  41. ncbi Comparison of the hemodynamic effects of milrinone with dobutamine in patients after cardiac surgery
    R O Feneck
    Department of Anesthesia, St Thomas' Hospital, London, United Kingdom
    J Cardiothorac Vasc Anesth 15:306-15. 2001
    OBJECTIVE: To compare the hemodynamic effects, efficacy, and safety of intravenous milrinone (M), 50 microg/kg during 10 minutes followed by 0...
  42. ncbi Milrinone administered before ischemia or just after reperfusion, attenuates myocardial stunning in anesthetized swine
    Tadasuke Use
    Department of Anesthesiology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, Japan
    Cardiovasc Drugs Ther 20:327-34. 2006
    We assessed the dose or timing effect of milrinone administered against myocardial stunning in 37 anesthetized open-chest swine.
  43. pmc Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts
    Shuhei Matsumoto
    Department of Anesthesiology, Nagasaki University School of Medicine, Nagasaki, Japan
    Cardiovasc Diabetol 11:4. 2012
    The authors examined whether milrinone and levosimendan could exert cardiac postconditioning effects in rats under normoglycemia and hyperglycemia, and whether the effects could be mediated by mitochondrial permeability transition pore (..
  44. ncbi Effects of milrinone versus epinephrine on left ventricular relaxation after cardiopulmonary bypass following myocardial revascularization: assessment by color m-mode and tissue Doppler
    Emilio B Lobato
    Department of Anesthesiology, University of Florida College of Medicine and Veterans Affairs Medical Center, Gainesville, 32610, USA
    J Cardiothorac Vasc Anesth 19:334-9. 2005
    The purpose of this study was to evaluate the left ventricular lusitropic effects of epinephrine versus milrinone after cardiopulmonary bypass.
  45. ncbi Hemodynamic management and outcome of patients treated for cerebral vasospasm with intraarterial nicardipine and/or milrinone
    Ulrich Schmidt
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Anesth Analg 110:895-902. 2010
    ..Although endovascular treatment with intraarterial nicardipine and milrinone is an accepted clinical treatment strategy, there is little information either on hemodynamic management during ..
  46. ncbi Inotropes improve right heart function in patients undergoing aortic valve replacement for aortic stenosis
    Andrew D Maslow
    Departments of Anesthesia and Surgery, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    Anesth Analg 98:891-902, table of contents. 2004
    ..Thirty-four patients were prospectively randomized to one of three groups: epinephrine, milrinone, or placebo...
  47. ncbi Milrinone enhances systolic, but not diastolic function during coronary artery bypass grafting surgery
    Pierre Couture
    Department of Anesthesiology, Montreal Heart Institute, Montreal, Quebec, Canada
    Can J Anaesth 54:509-22. 2007
    To evaluate the effect of milrinone on diastolic function during coronary artery bypass grafting surgery (CABG).
  48. ncbi Differential effects of amrinone and milrinone upon myocardial inflammatory signaling
    Nikhil K Chanani
    Department of Anesthesia, Children s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circulation 106:I284-9. 2002
    ..The mechanisms for these effects are unclear. We therefore examined the effects of 2 commonly used PDEIs, amrinone and milrinone, on cardiac cell inflammatory responses.
  49. ncbi Admission or changes in renal function during hospitalization for worsening heart failure predict postdischarge survival: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF)
    Liviu Klein
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Circ Heart Fail 1:25-33. 2008
    ..Less is known about the changes and relationships among these variables and the postdischarge survival rate...
  50. ncbi New milrinone analogues: in vitro study of structure-activity relationships for positive inotropic effect, antagonism towards endogenous adenosine, and inhibition of cardiac type III phosphodiesterase
    M Floreani
    Dipartimento di Farmacologia e Anestesiologia, Sezione di Farmacologia, Universita di Padova, 35131, Padova, Italy
    Naunyn Schmiedebergs Arch Pharmacol 367:109-18. 2003
    Two mechanisms are responsible for the positive inotropic effect of the cardiotonic drug milrinone, i.e., inhibition of type III cAMP phosphodiesterase (PDE III), and displacement of endogenous adenosine from A(1) inhibitory receptor...
  51. ncbi Greater vasopressin-induced vasoconstriction and inferior effects of nitrovasodilators and milrinone in the radial artery than in the internal thoracic artery
    Wei Wei
    Providence Heart Institute, Albery Starr Academic Center, Department of Surgery, Oregon Health and Science University, Portland, USA
    J Thorac Cardiovasc Surg 129:33-40. 2005
    ..This study compared the vasopressin-induced contraction and the effects of milrinone, nitroglycerin, and nitroprusside in vasopressin-induced contraction between the human radial artery and the ..
  52. ncbi Inhaled milrinone attenuates experimental acute lung injury
    Moritz Bueltmann
    Department of Anesthesiology, German Heart Institute, Berlin, Germany
    Intensive Care Med 35:171-8. 2009
    To test whether inhalation of the phosphodiesterase 3 inhibitor milrinone may attenuate experimental acute lung injury (ALI).
  53. ncbi Efficacy of pre-emptive milrinone in off-pump coronary artery bypass surgery: comparison between patients with a low and normal pre-graft cardiac index
    Y L Kwak
    Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei Cardiovascular Research Institute, Yonsei University School of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, South Korea
    Eur J Cardiothorac Surg 26:687-93. 2004
    The effect of pre-emptive milrinone without bolus during off-pump coronary artery bypass surgery (OPCAB) was evaluated in two groups of patients with low and normal pre-graft cardiac index.
  54. ncbi Slow induction of milrinone after coronary artery bypass grafting
    T Shibata
    Division of Cardiovascular Surgery, Second Department of Surgery, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka 545-8585, Japan
    Ann Thorac Cardiovasc Surg 7:23-7. 2001
    The aim of this study was to evaluate the hemodynamic effects of a slow induction of milrinone after open heart surgery...
  55. ncbi Suppressing apoptosis with milrinone simulating extracorporeal circulation: a pilot study
    E Usta
    Department of Thoracic, Cardiac and Vascular Surgery, Tubingen University Hospital, Tubingen, Germany
    Thorac Cardiovasc Surg 58:285-90. 2010
    ..In addition, the aim was to verify the anti-apoptotic properties of the phosphodiesterase 3 inhibitor milrinone.
  56. pmc Milrinone use is associated with postoperative atrial fibrillation after cardiac surgery
    Gregory A Fleming
    Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Circulation 118:1619-25. 2008
    ..Inotropic drugs are commonly used perioperatively to support ventricular function. This study tested the hypothesis that the use of inotropic drugs is associated with postoperative AF...
  57. ncbi Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase
    S Sanada
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    Circulation 104:705-10. 2001
    ..Methods and Results-- Milrinone, olprinone (PDEIII-Is), or dibutyryl-cAMP (db-cAMP) was injected intravenously 30 minutes before 90-minute ..
  58. ncbi Milrinone improves diastolic function in coronary artery bypass surgery as assessed by acoustic quantification and peak filling rate: a prospective randomized study
    Birger Axelsson
    Department of Cardiothoracic Surgery and Anesthesiology, Orebro University Hospital, Orebro, Sweden
    J Cardiothorac Vasc Anesth 24:244-9. 2010
    To compare the effects of a bolus dose of milrinone, 50 microg/kg, to placebo on diastolic function (active relaxation) in patients undergoing on-pump coronary artery bypass grafting (CABG).
  59. ncbi Predictors of inotrope use during separation from cardiopulmonary bypass
    Kenneth H McKinlay
    Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 18:404-8. 2004
    ..Design: Retrospective study of consecutive patients undergoing coronary artery bypass graft (CABG) surgery...
  60. ncbi A population pharmacokinetic analysis of milrinone in pediatric patients after cardiac surgery
    James M Bailey
    Emory University School of Medicine, Atlanta, GA, USA
    J Pharmacokinet Pharmacodyn 31:43-59. 2004
    The purpose of this study was to ascertain the optimal pharmacokinetic model for milrinone in pediatric patients after cardiac surgery when milrinone was administered as a slow loading dose followed by a constant-rate infusion...
  61. ncbi Effects of low-dose milrinone on weaning from cardiopulmonary bypass and after in patients with mitral stenosis and pulmonary hypertension
    Ilhan Oztekin
    Anesthesiology Department, Siyami Ersek Thoracic and Cardiovascular Surgery Hospital, Haydarpasa, Istanbul, Turkey
    Yakugaku Zasshi 127:375-83. 2007
    The phosphodiesterase inhibitor milrinone is usually preferred in patients with pulmonary hypertension and myocardial dysfunction after cardiopulmonary bypass...
  62. ncbi Haemodynamic effects of a milrinone infusion without a bolus in patients undergoing off-pump coronary artery bypass graft surgery
    Y L Kwak
    Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University School of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
    Anaesthesia 59:324-31. 2004
    The haemodynamic effects of a continuous infusion of milrinone without an initial bolus dose were evaluated in patients undergoing off-pump coronary artery bypass graft surgery. After internal mammary artery harvest, milrinone 0.5 microg...
  63. ncbi Effect of aerosolized milrinone during drug-induced pulmonary hypertension in lambs
    Javier Gelvez
    Division of Critical Care Medicine, Miami Children s Hospital, 3100 SW 62nd Avenue, Miami, FL 33156 3009, USA
    Pharmacol Res 50:87-91. 2004
    We tested whether aerosolized milrinone in lambs selectively reduces drug-induced acute pulmonary hypertension without reducing the mean systemic blood pressure (MSBP)...
  64. pmc The effect of milrinone on the right ventricular function in patients with reduced right ventricular function undergoing off-pump coronary artery bypass graft surgery
    Jong Hwa Lee
    Department of Anesthesiology and Pain Medicine, College of Medicine, Yonsei University, Seoul, Korea
    J Korean Med Sci 21:854-8. 2006
    This investigation evaluated the effect of continuous milrinone infusion on right ventricular (RV) function during off-pump coronary artery bypass graft (OPCAB) surgery in patients with reduced RV function...
  65. ncbi Mechanisms of a reduced cardiac output and the effects of milrinone and levosimendan in a model of infant cardiopulmonary bypass
    Christian F Stocker
    Departments of Intensive Care, The Royal Children s Hospital, Melbourne, Australia
    Crit Care Med 35:252-9. 2007
    ..The objectives of our study were to define the early precipitants of the reduced cardiac output and to investigate the effects on these of milrinone and levosimendan in a model of pediatric cardiopulmonary bypass.
  66. ncbi Development of decompensated dilated cardiomyopathy is associated with decreased gene expression and activity of the milrinone-sensitive cAMP phosphodiesterase PDE3A
    C J Smith
    Department of Pathology, New York Medical College, Valhalla 10595, USA
    Circulation 96:3116-23. 1997
    ..Little is known about relative changes in PDE3 activity or gene expression during the evolution of cardiomyopathy...
  67. ncbi Milrinone improves oxygenation in neonates with severe persistent pulmonary hypertension of the newborn
    Patrick J McNamara
    Division of Neonatology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    J Crit Care 21:217-22. 2006
    ..b>Milrinone is a promising adjunctive therapy because of its pulmonary vasodilator properties and cardiotropic effects.
  68. ncbi Preliminary experience with inhaled milrinone in cardiac surgery
    Yoan Lamarche
    Research Center, Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street, Montreal, Quebec H, Canada
    Eur J Cardiothorac Surg 31:1081-7. 2007
    Inhaled administration of milrinone reduces pulmonary artery pressure. Pulmonary hypertension (PH) and right heart failure are associated with difficult separation from cardiopulmonary bypass (CPB)...
  69. pmc Population pharmacokinetics and dosing regimen design of milrinone in preterm infants
    Mary Paradisis
    Department of Newborn Care, RPA Women and Babies Hospital, Camperdown, NSW, Australia
    Arch Dis Child Fetal Neonatal Ed 92:F204-9. 2007
    To define the pharmacokinetics of milrinone in very preterm infants and determine an optimal dose regimen to prevent low systemic blood flow in the first 12 h after birth.
  70. ncbi Effects of milrinone for right ventricular failure after left ventricular assist device implantation
    Shin ichiro Kihara
    Department of Cardiovascular Surgery, Heart Institute of Japan, Tokyo Women s Medical University
    Heart Vessels 16:69-71. 2002
    ..with right ventricular failure after left ventricular assist device implantation successfully treated with milrinone. Both had residual pulmonary hypertension due to high pulmonary vascular resistance after left ventricular ..
  71. ncbi The efficacy of preemptive Milrinone or Amrinone therapy in patients undergoing coronary artery bypass grafting
    Mutsuhito Kikura
    Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Anesth Analg 94:22-30, table of contents. 2002
    ..We hypothesized that milrinone or amrinone may reduce their occurrence and catecholamine requirements and increase cellular enzyme levels in ..
  72. ncbi Comparison of milrinone versus nitroglycerin, alone and in combination, on grafted internal mammary artery flow after cardiopulmonary bypass: effects of alpha-adrenergic stimulation
    E B Lobato
    Department of Anesthesiology, University of Florida College of Medicine, PO Box 100254, Gainesville, FL 32610 0254, USA
    J Cardiothorac Vasc Anesth 15:723-7. 2001
    To compare changes in blood flow in a grafted internal mammary artery (IMA) after cardiopulmonary bypass (CPB) in response to the administration of milrinone or nitroglycerin and to establish the effects of alpha-adrenergic stimulation.
  73. ncbi Milrinone versus dobutamine in heart failure subjects treated chronically with carvedilol
    B D Lowes
    University of Colorado Health Sciences Center, Denver, Colorado, CO 80262, USA
    Int J Cardiol 81:141-9. 2001
    To compare the efficacy of milrinone and dobutamine in patients chronically treated with carvedilol.
  74. ncbi The additive pulmonary vasodilatory effects of inhaled prostacyclin and inhaled milrinone in postcardiac surgical patients with pulmonary hypertension
    A Haraldsson s
    Department of Anesthesia and Intensive Care, Sahlgrenska University Hospital, , Sweden
    Anesth Analg 93:1439-45, table of contents. 2001
    ..We hypothesized that milrinone, an adenosine-3',5'-cyclic monophosphate (cAMP)-selective phosphodiesterase enzyme (PDE) inhibitor may, when ..
  75. ncbi Comparison of inhaled and intravenous milrinone in patients with pulmonary hypertension undergoing mitral valve surgery
    Hongmei Wang
    Department of Anesthesiology, Second Affiliated Hospital, Zhejiang University, Hangzhou, China
    Adv Ther 26:462-8. 2009
    ..The aim of this study was to investigate the postoperative hemodynamic effects of milrinone inhalation, and determine whether it has a selective effect of pulmonary vasodilation in patients with pulmonary ..
  76. ncbi Prognosis on chronic dobutamine or milrinone infusions for stage D heart failure
    Eiran Z Gorodeski
    Section of Heart Failure and Cardiac Transplant Medicine, Kaufman Center for Heart Failure, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Circ Heart Fail 2:320-4. 2009
    There are no published clinical trials comparing dobutamine with milrinone in outpatients with stage D heart failure on continuous inotropes.
  77. ncbi A multicenter, randomized, blind comparison of amrinone with milrinone after elective cardiac surgery
    J P Rathmell
    Department of Anesthesiology, University of Vermont College of Medicine, Burlington 05401, USA
    Anesth Analg 86:683-90. 1998
    Amrinone and milrinone are phosphodiesterase inhibitors with positive inotropic effects useful for the treatment of ventricular dysfunction after cardiac surgery...
  78. ncbi Selective pulmonary vasodilation with inhaled aerosolized milrinone in heart transplant candidates
    Armin Sablotzki
    Clinic of Anesthesiology and Intensive Care Medicine, Martin Luther University of Halle Wittenberg, Halle, Germany
    Can J Anaesth 52:1076-82. 2005
    ..A pilot study was under-taken to test the hypothesis that inhaled aerosolized milrinone may cause selective pulmonary vasodilation.
  79. ncbi Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support
    Michel White
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada, H1T 1C8
    Clin Sci (Lond) 110:483-9. 2006
    ..C-reactive protein) were measured by ELISA and colorimetric assays at admission and 30 days following 72-h milrinone (n=15) or dobutamine (n=14) infusion...
  80. ncbi Comparative hemodynamic effects of vasopressin and norepinephrine after milrinone-induced hypotension in off-pump coronary artery bypass surgical patients
    Yunseok Jeon
    Department of Anesthesiology, Seoul National University Hospital, Seoul, Republic of Korea
    Eur J Cardiothorac Surg 29:952-6. 2006
    ..We hypothesized that vasopressin could recover hypotension induced by milrinone with less effect on pulmonary vascular resistance (PVR) compared to norepinephrine.
  81. pmc The metabolic and renal effects of adrenaline and milrinone in patients with myocardial dysfunction after coronary artery bypass grafting
    Matthias Heringlake
    Department of Anesthesiology, Universitat zu Lubeck, D 23538 Lubeck, Germany
    Crit Care 11:R51. 2007
    ..This prospective, randomized pilot study analyzes the metabolic and renal effects of the inotropes adrenaline and milrinone in patients needing inotropic support after coronary artery bypass grafting (CABG).
  82. ncbi Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) s
    Liviu Klein
    Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Circulation 111:2454-60. 2005
    ..The prognostic value of serum sodium in patients hospitalized for worsening heart failure has not been well defined...
  83. ncbi Heart failure etiology and response to milrinone in decompensated heart failure: results from the OPTIME-CHF study
    G Michael Felker
    Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Am Coll Cardiol 41:997-1003. 2003
    The goal of this study was to assess the interaction between heart failure (HF) etiology and response to milrinone in decompensated HF.
  84. ncbi Nebulized milrinone use in a pulmonary hypertensive crisis
    Mitchell S Buckley
    Department of Pharmacy, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    Pharmacotherapy 27:1763-6. 2007
    ..b>Milrinone, a phosphodiesterase inhibitor, remains a therapeutic option...
  85. ncbi Inhaled but not intravenous milrinone prevents pulmonary endothelial dysfunction after cardiopulmonary bypass
    Y Lamarche
    Research Center, and Department of Surgery, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada
    J Thorac Cardiovasc Surg 130:83-92. 2005
    ..b>Milrinone is a type III phosphodiesterase inhibitor...
  86. pmc Combined milrinone and enteral metoprolol therapy in patients with septic myocardial depression
    Christian A Schmittinger
    Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Crit Care 12:R99. 2008
    ..The multifactorial etiology of septic cardiomyopathy is not fully elucidated. Recently, high catecholamine levels have been suggested to contribute to impaired myocardial function...
  87. ncbi Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial
    Michael S Cuffe
    Northwestern University Medical School, Division of Cardiology, 201 E Huron St, Galter 10 240, Chicago, IL 60611, USA
    JAMA 287:1541-7. 2002
    ..Although intravenous inotropic therapy usually produces beneficial hemodynamic effects and is labeled for use in the care of such patients, the effect of such therapy on intermediate-term clinical outcomes is uncertain...
  88. ncbi Effect of vasodilation by milrinone, a phosphodiesterase III inhibitor, on vasospastic arteries after a subarachnoid hemorrhage in vitro and in vivo: effectiveness of cisternal injection of milrinone
    Mitsuhisa Nishiguchi
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, Japan
    Neurosurgery 66:158-64; discussion 164. 2010
    Cerebral vasospasm remains a major cause of morbidity and mortality. Milrinone, a bipyridine phosphodiesterase III inhibitor, is a potent member of the inodilator class of cardiac agents for vasospasm and is injected intra-arterially or ..
  89. ncbi Rapid assessment and safe management of severe pulmonary hypertension with milrinone during orthotopic liver transplantation
    Kyota Fukazawa
    Division of Solid Organ Transplantation, Department of Anesthesiology, Preoperative Medicine and Pain Management, University of Miami Leonard M Miller School of Medicine, Miami, FL 33136, USA
    Clin Transplant 24:515-9. 2010
    ..We quickly determined the reversibility of PPHN with a bolus of milrinone and proceeded with OLT...
  90. ncbi Use of combination therapy with a beta-blocker and milrinone in patients with advanced heart failure
    Douglas L Jennings
    Department of Pharmacy, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48201, USA
    Ann Pharmacother 43:1872-6. 2009
    To review the literature evaluating the clinical effects of combination therapy with a beta-blocker and milrinone in patients with severe heart failure (HF).
  91. ncbi Milrinone for persistent pulmonary hypertension of the newborn
    Dirk Bassler
    Department of Neonatology, University Children s Hospital, Tuebingen, Germany
    Cochrane Database Syst Rev 11:CD007802. 2010
    ..However, iNO is not available in all countries and not all infants will respond to iNO. Milrinone is a phosphodiesterase III inhibitor which induces pulmonary vasodilatation by its actions through a cyclic ..
  92. ncbi Effects of milrinone and butyrolactone-I on porcine oocyte meiotic progression and developmental competence
    Christopher G Grupen
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, The University of Adelaide, The Queen Elizabeth Hospital, Woodville Road, Woodville, SA 5011, Australia
    Reprod Fertil Dev 18:309-17. 2006
    ..With the aim of improving this coordination, the effects of milrinone, an inhibitor of type 3 phosphodiesterases, and butyrolactone-I, a selective inhibitor of cdc2 kinases, on ..
  93. ncbi Potential greater than additive vasorelaxant actions of milrinone and nitroglycerin on human conduit arteries
    G W He
    Albert Starr Academic Center for Cardiac Surgery, St Vincent Hospital and Medical Center, Portland, Oregon, USA
    Br J Clin Pharmacol 41:101-7. 1996
    ..The purpose of this study was to test the hypothesis that the phosphodiesterase III inhibitor milrinone and nitroglycerin (NTG) may have greater than additive effects in human arteries. 2...
  94. ncbi Effects of levosimendan and milrinone on oxygen consumption in isolated guinea-pig heart
    Petri Kaheinen
    Orion Pharma, Espoo, Finland
    J Cardiovasc Pharmacol 43:555-61. 2004
    ..a novel calcium sensitizer that increases contraction force without change in intracellular calcium ([Ca2+]i); milrinone is a phosphodiesterase inhibitor that exerts a positive inotropic effect by increasing [Ca2+]i...
  95. ncbi Milrinone increases middle cerebral artery blood flow velocity after cardiopulmonary bypass
    Cheri A Sulek
    Department of Anesthesiology, University of Florida College of Medicine, and Veterans Affairs Medical Center, Gainesville, FL 32610, USA
    J Cardiothorac Vasc Anesth 16:64-9. 2002
    To evaluate the effects of milrinone on middle cerebral artery blood flow velocity (Vmca) and pulsatility index (PI) during normocapnia and hyperventilation in adults after cardiopulmonary bypass (CPB).
  96. ncbi Dose-response effects of milrinone on hemodynamics of newborn pigs with hypoxia-reoxygenation
    Chloe Joynt
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
    Intensive Care Med 34:1321-9. 2008
    Neonatal asphyxia causes cardiogenic shock and pulmonary hypertension with decreased brain perfusion. We examined the dose-response of milrinone on systemic, pulmonary, and carotid circulations in a model of neonatal hypoxia-reoxygenation.
  97. ncbi Arterial baroreflex sensitivity is a good predictor of inotropic responses to a phosphodiesterase inhibitor in human heart failure
    Naoki Sato
    Intensive and Cardiac Care Unit, Nippon Medical School, Tokyo, Japan
    Clin Cardiol 29:263-7. 2006
    ..However, whether arterial baroreflex function is related to the inotropic responsiveness to a PDEI has not been clarified in human heart failure (HF)...
  98. ncbi [Phosphodiesterase III inhibitor--characteristics, mechanisms of action, pharmacokinetics, indications, contraindications, clinical trials, and side effects]
    Naoki Sato
    Intensive and Cardiac Care Unit, Nippon Medical School
    Nihon Rinsho 65:43-8. 2007
  99. pmc Metabolic effects of phosphodiesterase III inhibitors: another reason to promote their use?
    Vladislava Simkova
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum, Parkstrasse 11, D 89073 Ulm, Germany
    Crit Care 11:139. 2007
    ..Their effects on energy metabolism and visceral organ function are not well studied, however, particularly in comparison with their 'competitors' in daily practice (that is, catecholamines)...
  100. ncbi Optimizing outcomes in the patient with acute decompensated heart failure
    Mandeep R Mehra
    Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, MD, USA
    Am Heart J 151:571-9. 2006
    ....
  101. ncbi Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O2 consumption in dogs
    Patricia N Banfor
    Department of Integrative Pharmacology R46R, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064 6119, USA
    Am J Physiol Heart Circ Physiol 294:H238-48. 2008
    ..Results were compared with those of the beta(1)-agonist dobutamine and the phosphodiesterase 3 inhibitor milrinone. Peak concentrations of levosimendan, OR-1896, and OR-1855 were 455 +/- 21, 126 +/- 6, and 136 +/- 6 ng/ml, ..

Research Grants15

  1. MYOCARDIAL ENERGY METABOLISM IN THE DYSFUNCTIONAL LV
    Jianyi Zhang; Fiscal Year: 2003
    ..be produced by direct stimulation of adenylyl cyclase with forskolin or by inhibition of phosphodiesterase with milrinone in addition to catecholamine infusion...
  2. ACUTE BRAIN INJURY AFTER SUBARACHNOID HEMORRHAGE
    Joshua Bederson; Fiscal Year: 2001
    ..c-AMP phosphodiesterase (PDE) inhibitor papaverine hydrochloride or the type III cAMP-specific PDE inhibitor Milrinone, and for alpha adrenergic blockade the selective alpha 1 antagonist Benextramine...
  3. PHARMACOLOGY OF DEVELOPING CARDIAC TISSUES
    Achilles Pappano; Fiscal Year: 2000
    ..The applicant will determine whether selective blockers of cGMP-inhibited PDE, milrinone, interfere with the stimulatory effect of muscarinic agonists...
  4. Regulation of Mammalian Oocyte Maturation
    Stephen Downs; Fiscal Year: 2007
    ..Furthermore, these studies will benefit the development of in vitro systems where either meiotic arrest or completion of meiotic maturation is the desired endpoint. ..
  5. Decision Making in End-Stage Heart Failure
    Paul Hauptman; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  6. CYCLIC AMP/ADENOSINE PATHWAY
    Edwin Jackson; Fiscal Year: 2002
    ..abstract_text> ..
  7. Engineering a CFTR Deficient Porcine Model of CF
    SCOTT O GRADY; Fiscal Year: 2007
    ..abstract_text> ..
  8. Molecular Control of cGMP Signaling by PKGs and PDEs
    Jackie Corbin; Fiscal Year: 2007
    ..A thorough physical and biochemical characterization of PDE11 will be carded out, and the likelihood of regulation of this enzyme by ligand binding to its GAF domains or by enzyme phosphorylation will be explored. ..
  9. Molecular Mechanisms of PDE5 Regulation
    Jackie Corbin; Fiscal Year: 2005
    ..Results of these studies will provide a basis for understanding fundamental questions relating to cGMP signaling in many tissues. ..
  10. PKC-EHN-PKD signal complex in cardiac remodeling
    Masahiko Hoshijima; Fiscal Year: 2009
    ..abstract_text> ..
  11. PDE3 Inhibitors: Selective Blockers of Oocyte Maturation
    Jeffrey Jensen; Fiscal Year: 2007
    ..This approach is expected to provide a foundation for future Phase 1 trials of PDE3 inhibitors in humans. ..
  12. Renin regulation by nitric oxide
    WILLIAM BEIERWALTES; Fiscal Year: 2007
    ..These studies should reveal the dual pathways by which NO can either inhibit or stimulate renin secretion. ..
  13. SEXUAL DIFFERENTIATION OF MOUSE VOMERONASAL FUNCTION
    James Cherry; Fiscal Year: 2004
    ....
  14. ACTION-A CHF TRIAL INVESTIGATING OUTCOMES OF EXERCISE
    William Abraham; Fiscal Year: 2005
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  15. Ischemic Arrest, Cytokines, and Organ Dysfunction
    James Niemann; Fiscal Year: 2008
    ..In aim 3, the effect of anti-TNF therapy on long-term survival and neurologic outcome will be evaluated. [unreadable] [unreadable]..