2 naphthylamine

Summary

Summary: A naphthalene derivative with carcinogenic action.

Top Publications

  1. pmc Site-directed fluorescence labeling of a membrane protein with BADAN: probing protein topology and local environment
    Rob B M Koehorst
    Laboratory of Biophysics, Wageningen University, Wageningen, The Netherlands
    Biophys J 94:3945-55. 2008
  2. pmc Nanosecond dynamics of a mimicked membrane-water interface observed by time-resolved stokes shift of LAURDAN
    Michel Vincent
    LURE Laboratoire pour l Utilisation du Rayonnement Electromagnétique, Universite Paris Sud, Batiment 209d, Orsay, France
    Biophys J 88:4337-50. 2005
  3. pmc Measurement of solvation responses at multiple sites in a globular protein
    Paul Abbyad
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Phys Chem B 111:8269-76. 2007
  4. ncbi Phosphorylation and binding interactions of CheY studied by use of Badan-labeled protein
    Richard C Stewart
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    Biochemistry 43:8766-77. 2004
  5. ncbi Spatial relationship between the prodan site, Trp-214, and Cys-34 residues in human serum albumin and loss of structure through incremental unfolding
    Shyam Sundar Krishnakumar
    Bhupat and Jyoti Mehta School of Biosciences and Bioengineering, Indian Institute of Technology, Bombay, Powai, Mumbai 400 076, India
    Biochemistry 41:7443-52. 2002
  6. ncbi Microfluorometry of cell membrane dynamics
    Petra Weber
    Hochschule Aalen, Institut fur Angewandte Forschung, 73430 Aalen, Germany
    Cytometry A 69:185-8. 2006
  7. ncbi Temperature and pressure effects on structural and conformational properties of POPC/SM/cholesterol model raft mixtures--a FT-IR, SAXS, DSC, PPC and Laurdan fluorescence spectroscopy study
    Chiara Nicolini
    University of Dortmund, Department of Chemistry, Physical Chemistry I Biophysical Chemistry, Otto Hahn Strasse 6, D 44227 Dortmund, Germany
    Biochim Biophys Acta 1758:248-58. 2006
  8. ncbi Visualizing membrane microdomains by Laurdan 2-photon microscopy
    Katharina Gaus
    Centre for Vascular Research at the School of Medical Sciences, University of New South Wales and the Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    Mol Membr Biol 23:41-8. 2006
  9. pmc A two-photon view of an enzyme at work: Crotalus atrox venom PLA2 interaction with single-lipid and mixed-lipid giant unilamellar vesicles
    Susana A Sanchez
    Department of Physics, Laboratory for Fluorescence Dynamics, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Biophys J 82:2232-43. 2002
  10. pmc Segregation of saturated chain lipids in pulmonary surfactant films and bilayers
    Kaushik Nag
    Department of Obstetrics and Gynecology, University of Western Ontario, London, Ontario N6A 5A5, Canada
    Biophys J 82:2041-51. 2002

Research Grants

  1. GENETIC SUSCEPTIBILITY TO AROMATIC AMINE TOXICITY
    CHARLENE MCQUEEN; Fiscal Year: 1992
  2. The Urokinase-CD87 System in Macrophage Activation
    Robert Sitrin; Fiscal Year: 2004
  3. New Coding Vectors for microRNA and siRNA
    Kevin Ryan; Fiscal Year: 2006
  4. Lipid Raft Microdomains in Neutrophil Function
    ROBERT GARY SITRIN; Fiscal Year: 2010

Detail Information

Publications179 found, 100 shown here

  1. pmc Site-directed fluorescence labeling of a membrane protein with BADAN: probing protein topology and local environment
    Rob B M Koehorst
    Laboratory of Biophysics, Wageningen University, Wageningen, The Netherlands
    Biophys J 94:3945-55. 2008
    ....
  2. pmc Nanosecond dynamics of a mimicked membrane-water interface observed by time-resolved stokes shift of LAURDAN
    Michel Vincent
    LURE Laboratoire pour l Utilisation du Rayonnement Electromagnétique, Universite Paris Sud, Batiment 209d, Orsay, France
    Biophys J 88:4337-50. 2005
    ..The measured relaxation time values were in the range of the rotational motion of the AOT polar headgroup region as assessed by LAURDAN and TOE fluorescence anisotropy decays...
  3. pmc Measurement of solvation responses at multiple sites in a globular protein
    Paul Abbyad
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Phys Chem B 111:8269-76. 2007
    ..The proper treatment of dynamic Stokes shift data when the time scale for solvation is comparable to the fluorescence lifetime is discussed...
  4. ncbi Phosphorylation and binding interactions of CheY studied by use of Badan-labeled protein
    Richard C Stewart
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    Biochemistry 43:8766-77. 2004
    ..These results provide insights into CheY interactions with CheA, CheZ, and other components of the chemotaxis signaling pathway...
  5. ncbi Spatial relationship between the prodan site, Trp-214, and Cys-34 residues in human serum albumin and loss of structure through incremental unfolding
    Shyam Sundar Krishnakumar
    Bhupat and Jyoti Mehta School of Biosciences and Bioengineering, Indian Institute of Technology, Bombay, Powai, Mumbai 400 076, India
    Biochemistry 41:7443-52. 2002
    ..In addition, the separation of domain I and II occurred before the global unfolding of the protein. The data support the idea that HSA loses its structure incrementally during its unfolding...
  6. ncbi Microfluorometry of cell membrane dynamics
    Petra Weber
    Hochschule Aalen, Institut fur Angewandte Forschung, 73430 Aalen, Germany
    Cytometry A 69:185-8. 2006
    ..Spectral properties are evaluated and displayed as microscopic images...
  7. ncbi Temperature and pressure effects on structural and conformational properties of POPC/SM/cholesterol model raft mixtures--a FT-IR, SAXS, DSC, PPC and Laurdan fluorescence spectroscopy study
    Chiara Nicolini
    University of Dortmund, Department of Chemistry, Physical Chemistry I Biophysical Chemistry, Otto Hahn Strasse 6, D 44227 Dortmund, Germany
    Biochim Biophys Acta 1758:248-58. 2006
    ..Interestingly, in this pressure range, ceasing of membrane protein function in natural membrane environments has been observed for a variety of systems...
  8. ncbi Visualizing membrane microdomains by Laurdan 2-photon microscopy
    Katharina Gaus
    Centre for Vascular Research at the School of Medical Sciences, University of New South Wales and the Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    Mol Membr Biol 23:41-8. 2006
    ..Moreover we discuss how microdomains identified by Laurdan microscopy are consistent with domains identified by other methodologies and put GP images in the context of current raft hypotheses...
  9. pmc A two-photon view of an enzyme at work: Crotalus atrox venom PLA2 interaction with single-lipid and mixed-lipid giant unilamellar vesicles
    Susana A Sanchez
    Department of Physics, Laboratory for Fluorescence Dynamics, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Biophys J 82:2232-43. 2002
    ..These studies emphasize the importance of lateral packing of the lipids in C. atrox sPLA2 enzymatic hydrolysis of a membrane surface...
  10. pmc Segregation of saturated chain lipids in pulmonary surfactant films and bilayers
    Kaushik Nag
    Department of Obstetrics and Gynecology, University of Western Ontario, London, Ontario N6A 5A5, Canada
    Biophys J 82:2041-51. 2002
    ....
  11. ncbi Fluorescence characteristics of hydrophobic partial agonist probes of the cholecystokinin receptor
    Kaleeckal G Harikumar
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Cancer Center, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
    Biosci Rep 26:89-100. 2006
    ..These data suggest that the partially activated conformational state of this receptor is more closely related to its fully active state than to its inactive state...
  12. ncbi Fluorescence detection of signs of sterol superlattice formation in lipid membranes
    Parkson Lee Gau Chong
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA
    Methods Mol Biol 400:159-70. 2007
    ..The principles and methodologies described here can be extended to other probes or bioactive molecules, such as enzymes, and can be applied to study sterol lateral organization in multicomponent lipid membranes...
  13. ncbi Effect of human Apo AIV against lipid peroxidation of very low density lipoproteins
    G Ferretti
    Faculty of Medicine, Institute of Biochemistry, University of Ancona, Via Ranieri, 60131, Ancona, Italy
    Chem Phys Lipids 114:45-54. 2002
    ....
  14. ncbi Propofol, a general anesthetic, promotes the formation of fluid phase domains in model membranes
    Sathyamangalam V Balasubramanian
    Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, 539 Cooke Hall, Amherst, NY 14260 1200, USA
    Chem Phys Lipids 114:35-44. 2002
    ..Based on these studies, we speculate that the mechanism of anesthetic action may involve effects on protein--lipid coupled systems through alterations in small-scale lipid domain structures...
  15. ncbi Use of steady-state laurdan fluorescence to detect changes in liquid ordered phases in human erythrocyte membranes
    Rebekah Vest
    Department of Physiology, Brigham Young University, Provo, Utah 84602, USA
    J Membr Biol 211:15-25. 2006
    ....
  16. ncbi Unique effects of different fatty acid species on the physical properties of the torpedo acetylcholine receptor membrane
    Silvia S Antollini
    Instituto de Investigaciones Bioquimicas de Bahia Blanca and UNESCO Chair of Biophysics and Molecular Neurobiology, B8000FWB Bahia Blanca, Argentina
    J Biol Chem 277:1249-54. 2002
    ....
  17. ncbi Influence of spectral heterogeneity of prodan and laurdan solutions on the transfer of electronic energy to octadecyl rhodamine B
    K A Kozyra
    Institute of Experimental Physics, University of Gdansk, Wita Stwosza 57, 80 952 Gdansk, Poland
    Biophys Chem 121:57-64. 2006
    ..The relative quenching efficiencies of both dyes depend on polarity of the medium and are higher for more polar solvent (AcN)...
  18. ncbi Coexistence of domains with distinct order and polarity in fluid bacterial membranes
    Sharon Vanounou
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Photochem Photobiol 76:1-11. 2002
    ..These results suggest a decrease in membrane heterogeneity caused by Cam-induced domain dissipation...
  19. ncbi Acrylodan-conjugated cysteine side chains reveal conformational state and ligand site locations of the acetylcholine-binding protein
    Ryan E Hibbs
    Department of Pharmacology, University of California San Diego, La Jolla, CA 92093 0636, USA
    J Biol Chem 279:28483-91. 2004
    ..Labeling at other residue positions around the predicted binding pocket also reveals distinctive spectral changes for alpha-bungarotoxin, agonists, and alkaloid antagonists...
  20. ncbi Lead-induced changes in human erythrocytes and lymphocytes
    E I Slobozhanina
    Institute of Photobiology of the National Academy of Sciences of Belarus, Academicheskaya Str 27, Minsk, 220072, Belarus
    J Appl Toxicol 25:109-14. 2005
    ....
  21. pmc Divalent cations increase lipid order in erythrocytes and susceptibility to secretory phospholipase A2
    Rebekah S Vest
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah 84620, USA
    Biophys J 86:2251-60. 2004
    ..These differences appeared related to the ability of the ions to induce a transition in erythrocyte shape...
  22. ncbi Phospholipid phase transitions in homogeneous nanometer scale bilayer discs
    Andrew W Shaw
    Department of Chemistry, University of Illinois, Urbana, IL 61801, USA
    FEBS Lett 556:260-4. 2004
    ..The broad transition of the Nanodisc lipid bilayer better mimics the phase behavior of cellular membranes than vesicles, making Nanodiscs a 'native-like' lipid environment in which to study membrane associated proteins...
  23. ncbi Fluorescence properties of Laurdan in cochleate phases
    Karthik Ramani
    Department of Pharmaceutical Sciences, 541 Cooke Hall, University at Buffalo, State University of New York, Amherst, NY 14260 1200, USA
    Biochim Biophys Acta 1618:67-78. 2003
    ..From these studies, we conclude that Laurdan fluorescence is a sensitive and a rapid method to detect cochleate phase formation...
  24. ncbi Effect of pressure on the Prodan fluorescence in bilayer membranes of phospholipids with varying acyl chain lengths
    Masataka Kusube
    Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2 1 Minamijosanjima, Tokushima 770 8506, Japan
    Colloids Surf B Biointerfaces 42:79-88. 2005
    ..The plot of F480/F430 versus pressure is available for recognition of the bilayer phase transitions, especially the bilayer interdigitation...
  25. ncbi Time-gated total internal reflection fluorescence spectroscopy (TG-TIRFS): application to the membrane marker laurdan
    H Schneckenburger
    Institut fur Lasertechnologien in der Medizin und Messtechnik an der Universitat Ulm, Ulm, Germany
    J Microsc 211:30-6. 2003
    ....
  26. ncbi Fluorescence probe study of Ca2+-dependent interactions of calmodulin with calmodulin-binding peptides of the ryanodine receptor
    Jaya Pal Gangopadhyay
    Boston Biomedical Research Institute, Watertown, MA 02472, USA
    Biochem Biophys Res Commun 323:760-8. 2004
    ..Based on our results we propose that both the interaction interface and the global conformation of the CaM-CaMBP complex are altered by calcium...
  27. ncbi Increased plasma concentrations of palmitoylethanolamide, an endogenous fatty acid amide, affect oxidative damage of human low-density lipoproteins: an in vitro study
    Giovanna Zolese
    Istituto di Biochimica, Via Ranieri 65, Universita Politecnica delle Marche, Ancona 60131, Italy
    Atherosclerosis 182:47-55. 2005
    ..1 microM), while the pro-oxidative effect is obtained at a higher PEA concentration (1 microM). Fluorescence and circular dichroism data indicate that the effect of PEA occurs mainly by affecting the conformational features of ApoB-100...
  28. ncbi Direct observation of lipid domains in free standing bilayers: from simple to complex lipid mixtures
    Luis A Bagatolli
    Grupo de Biofisica, Departamento de Química Biológica CIQUIBIC, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    Chem Phys Lipids 122:137-45. 2003
    ....
  29. ncbi Kinetic analysis of interdomain coupling in a lidless variant of the molecular chaperone DnaK: DnaK's lid inhibits transition to the low affinity state
    Sergey V Slepenkov
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    Biochemistry 41:12224-35. 2002
    ..New evidence in support of the reversible, two-step conformational switch mechanism is also presented...
  30. ncbi Use of laurdan fluorescence intensity and polarization to distinguish between changes in membrane fluidity and phospholipid order
    Faith M Harris
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    Biochim Biophys Acta 1565:123-8. 2002
    ..Thus, the same fluorescent probe can be used to distinguish effects of perturbations on membrane order and fluidity by comparing the results of fluorescence emission and anisotropy measurements...
  31. ncbi Oleoylethanolamide protects human sperm cells from oxidation stress: studies on cases of idiopathic infertility
    Annarina Ambrosini
    Institute of Biochemistry, Polytechnic University of Marche, 60100 Ancona, Italy
    Biol Reprod 74:659-65. 2006
    ..Results of this study support the hypothesis of a possible protective action of oleoylethanolamide against reactive oxygen species, which could explain its beneficial effects on in vitro capacitated spermatozoa...
  32. ncbi A two-photon fluorescent probe for lipid raft imaging: C-laurdan
    Hwan Myung Kim
    Department of Chemistry and Center for Electro and Photo Responsive Molecules, Korea University, 1 Anamdong, Seoul 136 701, Korea
    Chembiochem 8:553-9. 2007
    ..Lipid rafts can be visualized by two-photon microscopy by using C-laurdan as a probe. Our results show that the lipid rafts cover 38 % of the cell surface...
  33. ncbi Metal ion-independent association of factor VIII subunits and the roles of calcium and copper ions for cofactor activity and inter-subunit affinity
    H Wakabayashi
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Biochemistry 40:10293-300. 2001
    ..Ca(2+) appears essential to promote the active conformation of factor VIII while Cu(2+) primarily enhances the intersubunit affinity...
  34. ncbi The use of solvent relaxation technique to investigate headgroup hydration and protein binding of simple and mixed phosphatidylcholine/surfactant bilayer membranes
    K Rieber
    IDEA AG, Frankfurter Ring 193 a, 80807 Munich, Germany
    Biochim Biophys Acta 1768:1050-8. 2007
    ..Interferon alfa-2b binds to mixed lipid bilayers peripherally, whereas melittin is deeply inserted into lipid membranes and affects their headgroup hydration and mobility measurably...
  35. pmc Lipid rafts reconstituted in model membranes
    C Dietrich
    Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, 27599, USA
    Biophys J 80:1417-28. 2001
    ..Overall, the notion that in biomembranes selected lipids could laterally aggregate to form more ordered, detergent-resistant lipid rafts into which glycosphingolipids partition is strongly supported by this study...
  36. ncbi Fluorescence studies of the interactions of ubiquinol-10 with liposomes
    Rosamaria Fiorini
    Biochemistry Institute, Marche Polytechnic University, Ancona, Italy
    Photochem Photobiol 84:209-14. 2008
    ..The results indicate that ubiquinol-10 molecules are mainly located at the polar-lipid interface, inducing changes in the physico-chemical properties of the bilayer microenvironment...
  37. ncbi Differential association of the pleckstrin homology domains of phospholipases C-beta 1, C-beta 2, and C-delta 1 with lipid bilayers and the beta gamma subunits of heterotrimeric G proteins
    T Wang
    Department of Physiology and Biophysics, State University of New York at Stony Brook 11794 8661, USA
    Biochemistry 38:1517-24. 1999
    ..By contrast, docking of the PH domain of PLC-beta2 with G-beta gamma is comparable to that of the full-length protein and may play a key role in G-beta gamma recognition...
  38. ncbi Preparation, stability, and in vitro performance of vesicles made with diblock copolymers
    J C Lee
    School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biotechnol Bioeng 73:135-45. 2001
    ..The results potentiate a broad new class of technologically useful, polymer-based vesicles...
  39. ncbi Surface properties of cholesterol-containing membranes detected by Prodan fluorescence
    E K Krasnowska
    Istituto di Neurobiologia e Medicina Molecolare, CNR, Viale Marx 15-43, 00137 Rome, Italy
    Biochim Biophys Acta 1511:330-40. 2001
    ....
  40. ncbi Monitoring the organization and dynamics of bovine hippocampal membranes utilizing Laurdan generalized polarization
    Soumi Mukherjee
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India
    Biochim Biophys Acta 1714:43-55. 2005
    ..These results constitute novel information on the dynamics of hippocampal membranes and its modulation by cholesterol depletion monitored using Laurdan fluorescence...
  41. ncbi Pressure-induced phase transitions of lipid bilayers observed by fluorescent probes Prodan and Laurdan
    Masataka Kusube
    Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2 1 Minamijosanjima, Tokushima 770 8506, Japan
    Biophys Chem 117:199-206. 2005
    ..The plot of F(480)/F(440) versus pressure seems to be useful for the recognition of bilayer phase transition, especially the bilayer interdigitation...
  42. ncbi Trifluoperazine induces domain formation in zwitterionic phosphatidylcholine but not in charged phosphatidylglycerol bilayers
    A B Hendrich
    Department of Biophysics, Wroclaw Medical University, ul. Chalubinskiego 10, 50-368, Wroclaw, Poland
    Biochim Biophys Acta 1510:414-25. 2001
    ..This may partially explain the mechanism of multidrug resistance modulation by trifluoperazine...
  43. ncbi Mitochondrial creatine kinase binding to phospholipids decreases fluidity of membranes and promotes new lipid-induced beta structures as monitored by red edge excitation shift, laurdan fluorescence, and FTIR
    T Granjon
    , , , 69622 Villeurbanne Cedex, France
    Biochemistry 40:6016-26. 2001
    ....
  44. ncbi Loss of apoB-100 secondary structure and conformation in hydroperoxide rich, electronegative LDL(-)
    T Parasassi
    Istituto di Medicina Sperimentale, CNR, Roma, Italy
    Free Radic Biol Med 31:82-9. 2001
    ..The looser monolayer packing apparently favors the new conformation of apoB-100 and its sinking into a more hydrophobic environment, possibly accounting for it reduced receptor binding properties...
  45. ncbi Conformation-sensitive steroid and fatty acid sites in the transmembrane domain of the nicotinic acetylcholine receptor
    Gaspar A Fernández Nievas
    Instituto de Investigaciones Bioquimicas de Bahia Blanca and UNESCO Chair of Biophysics and Molecular Neurobiology, C C 857, B8000FWB, Bahia Blanca, Argentina
    Biochemistry 46:3503-12. 2007
    ..Agonist-induced desensitization resulted in the masking of the sites observed in the absence of agonist, thus demonstrating the conformational sensitivity of FFA and steroid sites in the AChR...
  46. ncbi Biochemical basis for enhanced binding of peptide dimers to X-linked inhibitor of apoptosis protein
    Kathryn E Splan
    Department of Chemistry, Macalester College, 1600 Grand Avenue, St Paul, Minnesota 55105, USA
    Biochemistry 46:11938-44. 2007
    ....
  47. ncbi Effect-directed analysis of key toxicants in European river basins a review
    Werner Brack
    UFZ Centre for Environmental Research, Department of Effect Directed Analysis, Leipzig, Germany
    Environ Sci Pollut Res Int 14:30-8. 2007
    ..Thus, one focus of present European research is on toxicant identification in European river basins in order to allow for a reduction of toxic pressure on aquatic ecosystems according to the WFD...
  48. ncbi Performance of 181 chemicals in a Drosophila assay predominantly monitoring interchromosomal mitotic recombination
    E W Vogel
    Department of Radiation Genetics and Chemical Mutagenesis, Leiden, Netherlands
    Mutagenesis 8:57-81. 1993
    ..Their weak responses were always accompanied by signs of toxicity.(ABSTRACT TRUNCATED AT 400 WORDS)..
  49. pmc Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines
    M A Butler
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079
    Proc Natl Acad Sci U S A 86:7696-700. 1989
    ....
  50. ncbi Cathepsin activities and membrane integrity of zebrafish (Danio rerio) oocytes after freezing to -196 degrees C using controlled slow cooling
    T Zhang
    Institute of Research in the Applied Natural Sciences, University of Bedfordshire, The Spires, 2 Adelaide Street, Luton, Bedfordshire LU1 5DU, UK
    Cryobiology 56:138-43. 2008
    ..8% stayed intact after freezing in DMSO and methanol to -196 degrees C. The results indicate that cryoprotectant treatment and freezing modified the activities of lysosomal enzymes involved in oocyte maturation and yolk mobilisation...
  51. ncbi Fatty acids and glucose increase neutral endopeptidase activity in human microvascular endothelial cells
    Pornprom Muangman
    University of Washington, Department of Surgery, Harborview Medical Center, Seattle, Washington 98104, USA
    Shock 19:508-12. 2003
    ..with glutaryl-Ala-Ala-Phe-4-methoxy-beta naphthylamide to generate a fluorescent degradation product methoxy 2 naphthylamine. High glucose or fatty acid concentration upregulated NEP activity...
  52. ncbi The development of a MIP-optosensor for the detection of monoamine naphthalenes in drinking water
    Angel Valero-Navarro
    Department of Analytical Chemistry, University of Granada, c Fuentenueva s n, 18071 Granada, Spain
    Biosens Bioelectron 24:2305-11. 2009
    ..Finally, we applied it to the analysis of 1-NA and 2-NA in tap and mineral waters, obtaining a 98% average recovery rate...
  53. pmc Glycolipid transfer protein interaction with bilayer vesicles: modulation by changing lipid composition
    Chetan S Rao
    University of Minnesota, Hormel Institute, Austin, Minnesota 55912, USA
    Biophys J 89:4017-28. 2005
    ..A model of GLTP interaction with the membrane, based on the partitioning equilibrium data and consistent with the kinetics of GSL transfer, is presented and solved mathematically...
  54. ncbi Anchoring metabolic changes to phenotypic effects in the chlorophyte Scenedesmus vacuolatus under chemical exposure
    Frédéric Sans-Piché
    Department of Bioanalytical Ecotoxicology, UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
    Mar Environ Res 69:S28-30. 2010
    ....
  55. ncbi The practical synthesis of (2S)-7-methoxy-1,2,3,4-tetrahydro-2-naphthylamine via optical resolution of 2-(3-methoxybenzyl)succinic acid
    T Yanagi
    Central Research Laboratories, Kissei Pharmaceutical Co, Ltd, Minamiazumi, Nagano, Japan
    Chem Pharm Bull (Tokyo) 49:340-4. 2001
    ..S)-AMT was obtained from the acid (S)-2 by Hofmann rearrangement without racemization...
  56. ncbi Assessment of the performance of the Ames II assay: a collaborative study with 19 coded compounds
    S Flückiger-Isler
    Xenometrix by Endotell GmbH, CH 4125 Allschwil, Switzerland
    Mutat Res 558:181-97. 2004
    ....
  57. ncbi Variation in enzymes of arylamine procarcinogen biotransformation among bladder cancer patients and control subjects
    S A Vaziri
    Genetics and Genomnic Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Canada
    Pharmacogenetics 11:7-20. 2001
    ..arylamine procarcinogens in theory, interindividual variations in CYP1A2, NAT1 and NAT2 activities do not significantly differ between bladder cancer patients and control subjects when potential arylamine exposures are controlled for..
  58. ncbi Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization
    Yoichi Sakakibara
    Biomedical Research Center, The University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708, USA
    Gene 285:39-47. 2002
    ..Using mouse brain filtrate as substrate, both brain sulfotransferases were shown to catalyze specifically the sulfation of only a few compounds...
  59. ncbi Flow cytometry as a tool to study phytotoxic modes of action
    Nicole E Adler
    Umweltforschungszentrum UFZ Centre for Environmental Research Leipzig Halle, Department Bioanalytical Ecotoxicology, Permoserstrasse 15, 04318 Leipzig, Germany
    Environ Toxicol Chem 26:297-306. 2007
    ....
  60. ncbi Analysis of aromatic amines in cigarette smoke
    Regina Stabbert
    Philip Morris Research Laboratories GmbH, Fuggerstr 3, D 51149 Köln, Germany
    Rapid Commun Mass Spectrom 17:2125-32. 2003
    ..The results support the hypothesis that the nitrogen content of the tobacco, and above all the cigarette combustion temperature, are determining factors for the yields of aromatic amines in smoke...
  61. ncbi Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosa
    S Imaoka
    Laboratory of Chemistry, Osaka City University Medical School, Osaka, Japan
    Biochem Pharmacol 54:677-83. 1997
    ..These findings suggested that CYP4B1 could contribute to the initiation of carcinogenesis in rat and mouse bladder by activation of aromatic amines...
  62. ncbi Percutaneous absorption of aromatic amines - a contribution for human health risk assessment
    T Wellner
    Institute and Out Patient Clinic of Occupational, Social and Environmental Medicine, University Erlangen Nuremberg, Schillerstrasse 25 29, D 91054 Erlangen, Germany
    Food Chem Toxicol 46:1960-8. 2008
    ..The in vitro data support our recent findings in rubber industry workers that the percutaneous absorption may significantly contribute to overall exposure of AA...
  63. ncbi Possible relationship between the risk of Japanese bladder cancer cases and the CYP4B1 genotype
    Takamitsu Sasaki
    Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University, Sendai 981 8558, Japan
    Jpn J Clin Oncol 38:634-40. 2008
    ..We demonstrated the first genetic study regarding the association of CYP4B1 with bladder cancer. Our results suggest that CYP4B1 genotypes might have an effect on the risk of bladder cancer...
  64. ncbi NAT2 slow acetylation and bladder cancer in workers exposed to benzidine
    Tania Carreon
    Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA
    Int J Cancer 118:161-8. 2006
    ..Study findings suggest the existence of key differences in the metabolism of mono- and diarylamines...
  65. pmc Differential detection of phospholipid fluidity, order, and spacing by fluorescence spectroscopy of bis-pyrene, prodan, nystatin, and merocyanine 540
    Heather A Wilson-Ashworth
    Department of Biology, Utah Valley State College, Orem, UT 84058, USA
    Biophys J 91:4091-101. 2006
    ..Temperature variation at constant cholesterol content revealed three of the eight combinations identified in our analysis of liposomes...
  66. pmc Methodology to probe subunit interactions in ribonucleotide reductases
    A Quamrul Hassan
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biochemistry 47:13046-55. 2008
    ..4 microM for subunit interaction. Disruption of the interaction of the alpha2-DAN-beta2 complex is accompanied by a decrease in fluorescence intensity and can serve as a high-throughput screen for inhibitors of subunit interactions...
  67. ncbi Fluorescence spectroscopic studies of pressure effects on Na+,K(+)-ATPase reconstituted into phospholipid bilayers and model raft mixtures
    Ewa Powalska
    Department of Chemistry, Physical Chemistry I, and Biophysical Chemistry, University of Dortmund, Otto Hahn Strasse 6, D 44227 Dortmund, Germany
    Biochemistry 46:1672-83. 2007
    ..High pressures, above about 2.2 kbar, irreversibly change protein conformation, probably because of the dissociation and partial unfolding of the subunits...
  68. ncbi Erythrocyte plasma membrane perturbations in rats fed a cholesterol-rich diet: effect of drinking sulphurous mineral water
    Cinzia Nasuti
    Dottorato di Ricerca in Invecchiamento e Nutrizione, Universita di Camerino, Camerino, Italy
    Ann Nutr Metab 49:9-15. 2005
    ..The purpose of the present study was to evaluate the ability of calcic and magnesic-sulphate-sulphurous spring mineral water (SMW) to reduce total and erythrocyte plasma membrane cholesterol in rats fed a cholesterol-rich diet...
  69. ncbi Reductive electron injection into duplex DNA by aromatic amines
    Takeo Ito
    Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA
    J Am Chem Soc 126:15552-9. 2004
    ....
  70. ncbi [Fluorescent molecular thermometers for bioimaging]
    Seiichi Uchiyama
    Tanpakushitsu Kakusan Koso 52:1608-12. 2007
  71. ncbi Photo-Fenton-like treatment of K-acid: assessment of treatability, toxicity and oxidation products
    Tugba Olmez-Hanci
    Istanbul Technical University, Faculty of Civil Engineering, Department of Environmental Engineering, 34469 Maslak, Istanbul, Turkey E mail
    Water Sci Technol 70:1056-64. 2014
    ..A common degradation pathway for photo-Fenton-like treatment of K-acid using different irradiation types was proposed. ..
  72. ncbi Microplate assay for cathepsin detection in viable cells using derivatives of 4-methoxy-beta-naphthylamide
    Anke Ruettger
    Institute of Biochemistry I, Universitatsklinikum, Friedrich Schiller Universitat Jena, Germany
    Curr Protoc Protein Sci . 2007
    ..The most common application of these assays is to compare directly cells treated with different substances, e.g., pharmaceutically interesting cathepsin inhibitors...
  73. ncbi Design and syntheses of 1,6-naphthalene derivatives as selective HCMV protease inhibitors
    Ariamala Gopalsamy
    Chemical and Screening Sciences and Infectious Diseases, Wyeth Research, Pearl River, NY 10965, USA
    J Med Chem 47:1893-9. 2004
    ..The optimization approach on lead compound 6 in three different regions of the molecule using parallel solution-phase synthesis and the corresponding SAR are discussed in detail...
  74. ncbi Chemometric-assisted MIP-optosensing system for the simultaneous determination of monoamine naphthalenes in drinking waters
    Angel Valero-Navarro
    Department of Analytical Chemistry, University of Granada, Granada, Spain
    Talanta 78:57-65. 2009
    ..Predictive ability, accuracy, figures of merit, as well as advantages and disadvantages of the different strategies were discussed...
  75. ncbi SecB-mediated protein export need not occur via kinetic partitioning
    Beena Krishnan
    Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India
    J Mol Biol 385:1243-56. 2009
    ....
  76. pmc Solubilization of lipid bilayers by myristyl sucrose ester: effect of cholesterol and phospholipid head group size
    C Toro
    Laboratorio de Cinética y Fotoquímica, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago, Chile
    Chem Phys Lipids 157:104-12. 2009
    ..ii) Insertion of cholesterol molecules into the lipid bilayer protects it from solubilizaton and (iii) the microscopic mechanism of solubilization by MMS implies the decrease in size of the individual liposomes...
  77. ncbi Phase transition affects energy transfer efficiency in phospholipid vesicles
    K A Kozyra
    Institute of Experimental Physics, University of Gdansk, ul Wita Stwosza 57, Gdansk, Poland
    Spectrochim Acta A Mol Biomol Spectrosc 61:1153-61. 2005
    ..The relative quenching efficiencies of both dyes depend on the phase state of the bilayer and indicate a deeper incorporation of PRODAN and LAURDAN into the membrane in its fluid phase than in its gel phase...
  78. pmc Biomolecular mimicry in the actin cytoskeleton: mechanisms underlying the cytotoxicity of kabiramide C and related macrolides
    Junichi Tanaka
    Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:13851-6. 2003
    ..KabC and related macrolides are useful probes to study the regulation of the actin filament (+) end and may lead to new therapies to treat diseases of the actin cytoskeleton...
  79. ncbi Impairment of telomeric quadruple helix formation - A possible event involved in the carcinogenicity of aromatic amines from the thermodynamic point of view?
    Sven Gunia
    Institute of Pathology, HELIOS Klinikum Bad Saarow, Charité University Medicine Teaching Hospital, Pieskower Strasse 33, 15526 Bad Saarow, Germany
    Med Hypotheses 75:123-5. 2010
    ....
  80. ncbi Membrane physical state as key parameter for the resistance of the gram-negative Bradyrhizobium japonicum to hyperosmotic treatments
    Laurent Beney
    Laboratoire de Genie des Procedes Alimentaires et Biotechnologiques, Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l Alimentation, 1 Esplanade Erasme, 21000 Dijon, France
    Arch Microbiol 187:387-96. 2007
    ..Cell resistance was finally related to modifications of the membrane structure depending on combined effects of cooling and dehydration...
  81. pmc Does PRODAN possess an O-TICT excited state? Synthesis and properties of two constrained derivatives
    Renata K Everett
    Department of Chemistry, College of William and Mary, Williamsburg, Virginia 23187 8795, USA
    J Phys Chem A 114:4946-50. 2010
    ....
  82. ncbi Determination of some aromatic amines in finger-paints for children's use by supercritical fluid extraction combined with gas chromatography
    M C Garrigos
    Analytical Chemistry Department, University of Alicante, Spain
    J Chromatogr A 819:259-66. 1998
    ..SFE was compared with Soxhlet extraction, and was found to give higher recoveries in all cases. Other commercial finger-paints were tested for the presence of aromatic amines...
  83. ncbi Solvatochromic probe response within ionic liquids and their equimolar mixtures with tetraethylene glycol
    Rewa Rai
    Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India
    J Phys Chem B 118:11259-70. 2014
    ....
  84. ncbi Span 80 vesicles have a more fluid, flexible and "wet" surface than phospholipid liposomes
    Keita Hayashi
    Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, Japan
    Colloids Surf B Biointerfaces 87:28-35. 2011
    ..Thus the present results confirmed that the Span 80 vesicle surfaces showed the unique characteristics of fluidity, flexibility, and "wetness", whereas the liposome surfaces did not...
  85. ncbi Calcium-induced conformational change in cardiac troponin C studied by fluorescence probes attached to Cys-84
    W J Dong
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham 35294 2041, USA
    Biochim Biophys Acta 1295:139-46. 1996
    ..The present results are consistent with a Ca(2+)-induced open conformation of the N-domain in cTnC...
  86. ncbi Effect of genistein against copper-induced lipid peroxidation of human high density lipoproteins (HDL)
    G Ferretti
    Institute of Biochemistry, Faculty of Medicine, University of Ancona, Via Ranieri, I 60131, Ancona, Italy
    Atherosclerosis 172:55-61. 2004
    ..Therefore, we suggested that antioxidant activity exerted by genistein against lipid peroxidation of HDL in vitro could be of physiological relevance...
  87. ncbi Resonance energy transfer between tryptophan-214 in human serum albumin and acrylodan, prodan, and promen
    José González-Jiménez
    Instituto de Estudios Biofuncionales and Departamento de Fisicoquímica Farmacéutica, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Protein J 23:351-5. 2004
    ..The distances calculated, 2.97 +/- 0.10 nm, 3.14 +/- 0.11 nm, and 2.62 +/- 0.17 nm, respectively, confirm the locations previously proposed for all three probes...
  88. ncbi Glycated low density lipoproteins modify platelet properties: a compositional and functional study
    G Ferretti
    Institute of Biochemistry, University of Ancona School of Medicine, Italy
    J Clin Endocrinol Metab 87:2180-4. 2002
    ..The present work demonstrates that glycation induces compositional and structural changes in LDL and suggests that an altered interaction between glycLDL and platelets might play a role in the vascular complications of diabetes...
  89. ncbi Bladder tumours in rubber workers: a factory study 1946-1995
    C A Veys
    Primary Care Sciences Research Centre, School of Postgraduate Medicine, Keele University, Keele, UK
    Occup Med (Lond) 54:322-9. 2004
    ..25%) in antioxidants used in manufacturing. This study follows a composite cohort of 6450 men employed at a large tyre factory either during the 'at-risk' period or just after it...
  90. ncbi Determination of selenium in human serum by liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry after acid digestion and derivatization using 2,3-diaminonaphthalene
    Masayuki Ando
    Department of Analytical Chemistry, Niigata University of Pharmacy and Applied Life Sciences, 5 13 2 Kamishinei cho, Niigata 950 2081, Japan
    Eur J Mass Spectrom (Chichester, Eng) 9:619-22. 2003
    ..The coefficient of variation of standard concentrations in control serum samples was 4.5%. The purity of the observed peak obtained from serum samples was confirmed using the ion cluster technique...
  91. ncbi Is contact allergy to disperse dyes and related substances associated with textile dermatitis?
    K Ryberg
    Department of Occupational and Environmental Dermatology, Lund University, Malmo University Hospital, Malmo, Sweden
    Br J Dermatol 160:107-15. 2009
    ..Disperse dyes (DDs) are the most common sensitizers among textile dyes, but there is little knowledge of the clinical relevance of positive patch test reactions...
  92. doi Microextraction by packed sorbent and salting-out-assisted liquid-liquid extraction for the determination of aromatic amines formed from azo dyes in textiles
    Miguel Del Nogal Sánchez
    Departamento de Quimica Analitica, Nutricion y Bromatologia, Facultad de Ciencias Quimicas, Universidad de Salamanca, 37008 Salamanca, Spain
    Talanta 119:375-84. 2014
    ..The results obtained in the analysis of textiles revealed the presence of o-anisidine, p-chloroaniline, 4-chloro-o-toluidine, 2-naphthylamine and 3,3'-dimethoxybenzidine in some of them...
  93. ncbi Androgen regulation of CYP4B1 responsible for mutagenic activation of bladder carcinogens in the rat bladder: detection of CYP4B1 mRNA by competitive reverse transcription-polymerase chain reaction
    S Imaoka
    Department of Chemical Biology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, 545 8585, Osaka, Japan
    Cancer Lett 166:119-23. 2001
    ..Furthermore, the present findings suggest that the sex difference observed in bladder carcinogenesis was due to sex-different expression of CYP4B1 in bladder tissue...
  94. ncbi Fluorometric measurement of nitrite/nitrate by 2,3-diaminonaphthalene
    Andreas K Nussler
    Department of General Visceral and Transplantation Surgery, University Medicine Berlin, Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Nat Protoc 1:2223-6. 2006
    ..02-10.0 microM. This restricted linear range suggests that the technique is useful for studying small changes of nitrite and nitrate, rather than for routine diagnostic measurements...
  95. ncbi The solubilisation pattern of lutein, zeaxanthin, canthaxanthin and beta-carotene differ characteristically in liposomes, liver microsomes and retinal epithelial cells
    Medhat Wahba Ismail Shafaa
    Institute for Biophysics, University of Bremen, PB 330440, D 28334 Bremen, Germany
    Biophys Chem 129:111-9. 2007
    ..Fetal calf serum as carrier for carotenoid incorporation appears superior to tetrahydrofuran...
  96. ncbi Features of absorption and fluorescence spectra of prodan
    Viktor Ya Artukhov
    Tomsk State University, Russia, Tomsk 50, Lenina 36, Russian Federation
    Spectrochim Acta A Mol Biomol Spectrosc 68:36-42. 2007
    ..The presence of the second band (about 24,000 cm(-1)) in fluorescence spectra of prodan in isopropyl (ethyl) alcohol-water solvents is explained...
  97. ncbi Re-evaluation of the latent period of bladder cancer in dyestuff-plant workers in Japan
    M Miyakawa
    Department of Humanity and Environment, Hosei University, Tokyo, Japan
    Int J Urol 8:423-30. 2001
    ..The purpose of this study was to re-evaluate the latent carcinogenic period of BZ and BNA, in order to set the safety period after exposure for the health surveillance system...
  98. ncbi Detection of carcinogenic aromatic amines in the urine of non-smokers
    G Grimmer
    Biochemisches Institut für Umweltcarcinogene, Grosshansdorf, Germany
    Sci Total Environ 247:81-90. 2000
    ..The detected urinary levels of aromatic amines arising from sources other than tobacco smoke or diesel exhaust may play a role in the bladder cancer etiology of non-smokers...
  99. ncbi The new fluorescent membrane probe Ahba: a comparative study with the largely used Laurdan
    Cíntia C Vequi-Suplicy
    Instituto de Fisica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    J Fluoresc 23:479-86. 2013
    ....
  100. ncbi Increase in three alpha,beta-dicarbonyl compound levels in human uremic plasma: specific in vivo determination of intermediates in advanced Maillard reaction
    H Odani
    Department of Internal Medicine, Nagoya University Daiko Medical Center, 1 1 20 Daiko Minami, Higashi ku, Nagoya, 461 0047, Japan
    Biochem Biophys Res Commun 256:89-93. 1999
    ..In both diabetic and uremic patients, these dicarbonyl compounds promote AGE accumulation in vivo, and especially in uremic patients, increased accumulation of GO could result from accelerating oxidative stress...
  101. ncbi Functionalization of a viscosity-sensitive fluorophore for probing of biological systems
    A Petric
    Faculty of Chemistry and Chemical Technology, University of Ljubljana, Slovenia
    Bioorg Med Chem Lett 8:1455-60. 1998
    ..Spiperone, a highly potent ligand for the dopamine D2 receptors, was conjugated via an ethylpiperazine moiety to the fluorophore giving fluorescent probes that can be excited in the UV and Vis range...

Research Grants4

  1. GENETIC SUSCEPTIBILITY TO AROMATIC AMINE TOXICITY
    CHARLENE MCQUEEN; Fiscal Year: 1992
    ..Animals will be exposed to aniline or benzidine and methemoglobin formation and splenic damage will be determined. DNA damage in erythrocytes, liver, kidney and spleen will be examined by adduct formation of DNA strand breaks...
  2. The Urokinase-CD87 System in Macrophage Activation
    Robert Sitrin; Fiscal Year: 2004
    ....
  3. New Coding Vectors for microRNA and siRNA
    Kevin Ryan; Fiscal Year: 2006
    ..abstract_text> ..
  4. Lipid Raft Microdomains in Neutrophil Function
    ROBERT GARY SITRIN; Fiscal Year: 2010
    ..Hopefully, targeting the function of lipid raft microdomains will engender new therapeutic strategies for enhancing antimicrobial defenses and suppressing the deleterious effects of acute inflammation. ..