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Nanosecond dynamics of a mimicked membrane-water interface observed by time-resolved stokes shift of LAURDANMichel Vincent
, , , Orsay, France
Biophys J 88:4337-50. 2005..The measured relaxation time values were in the range of the rotational motion of the AOT polar headgroup region as assessed by LAURDAN and TOE fluorescence anisotropy decays...- Measurement of solvation responses at multiple sites in a globular proteinPaul Abbyad
Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
J Phys Chem B 111:8269-76. 2007..The proper treatment of dynamic Stokes shift data when the time scale for solvation is comparable to the fluorescence lifetime is discussed... - Site-directed fluorescence labeling of a membrane protein with BADAN: probing protein topology and local environmentRob B M Koehorst
Laboratory of Biophysics, Wageningen University, Wageningen, The Netherlands
Biophys J 94:3945-55. 2008.... 
Lead-induced changes in human erythrocytes and lymphocytesE I Slobozhanina
Institute of Photobiology of the National Academy of Sciences of Belarus, Academicheskaya Str. 27, Minsk, 220072, Belarus
J Appl Toxicol 25:109-14. 2005....- Spatial relationship between the prodan site, Trp-214, and Cys-34 residues in human serum albumin and loss of structure through incremental unfoldingShyam Sundar Krishnakumar
Bhupat and Jyoti Mehta School of Biosciences and Bioengineering, Indian Institute of Technology, Bombay, Powai, Mumbai 400 076, India
Biochemistry 41:7443-52. 2002..In addition, the separation of domain I and II occurred before the global unfolding of the protein. The data support the idea that HSA loses its structure incrementally during its unfolding... - Phosphorylation and binding interactions of CheY studied by use of Badan-labeled proteinRichard C Stewart
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
Biochemistry 43:8766-77. 2004..These results provide insights into CheY interactions with CheA, CheZ, and other components of the chemotaxis signaling pathway... - Conformation-sensitive steroid and fatty acid sites in the transmembrane domain of the nicotinic acetylcholine receptorGaspar A Fernández Nievas
Instituto de Investigaciones Bioquimicas de Bahia Blanca and UNESCO Chair of Biophysics and Molecular Neurobiology, C C 857, B8000FWB, Bahia Blanca, Argentina
Biochemistry 46:3503-12. 2007..Agonist-induced desensitization resulted in the masking of the sites observed in the absence of agonist, thus demonstrating the conformational sensitivity of FFA and steroid sites in the AChR... - Resonance energy transfer between tryptophan-214 in human serum albumin and acrylodan, prodan, and promenJosé González-Jiménez
Instituto de Estudios Biofuncionales and Departamento de Fisicoquímica Farmacéutica, Universidad Complutense de Madrid, 28040 Madrid, Spain
Protein J 23:351-5. 2004..The distances calculated, 2.97 +/- 0.10 nm, 3.14 +/- 0.11 nm, and 2.62 +/- 0.17 nm, respectively, confirm the locations previously proposed for all three probes... - Glycated low density lipoproteins modify platelet properties: a compositional and functional studyG Ferretti
Institute of Biochemistry, University of Ancona School of Medicine, Italy
J Clin Endocrinol Metab 87:2180-4. 2002..The present work demonstrates that glycation induces compositional and structural changes in LDL and suggests that an altered interaction between glycLDL and platelets might play a role in the vascular complications of diabetes... - A two-photon view of an enzyme at work: Crotalus atrox venom PLA2 interaction with single-lipid and mixed-lipid giant unilamellar vesiclesSusana A Sanchez
Department of Physics, Laboratory for Fluorescence Dynamics, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
Biophys J 82:2232-43. 2002..These studies emphasize the importance of lateral packing of the lipids in C. atrox sPLA2 enzymatic hydrolysis of a membrane surface... - Segregation of saturated chain lipids in pulmonary surfactant films and bilayersKaushik Nag
Department of Obstetrics and Gynecology, University of Western Ontario, London, Ontario N6A 5A5, Canada
Biophys J 82:2041-51. 2002.... - The solubilisation pattern of lutein, zeaxanthin, canthaxanthin and beta-carotene differ characteristically in liposomes, liver microsomes and retinal epithelial cellsMedhat Wahba Ismail Shafaa
Institute for Biophysics, University of Bremen, PB 330440, D 28334 Bremen, Germany
Biophys Chem 129:111-9. 2007..Fetal calf serum as carrier for carotenoid incorporation appears superior to tetrahydrofuran... - Fluorescence probe study of Ca2+-dependent interactions of calmodulin with calmodulin-binding peptides of the ryanodine receptorJaya Pal Gangopadhyay
Boston Biomedical Research Institute, Watertown, MA 02472, USA
Biochem Biophys Res Commun 323:760-8. 2004..Based on our results we propose that both the interaction interface and the global conformation of the CaM-CaMBP complex are altered by calcium... - Effect of human Apo AIV against lipid peroxidation of very low density lipoproteinsG Ferretti
Faculty of Medicine, Institute of Biochemistry, University of Ancona, Via Ranieri, 60131, Ancona, Italy
Chem Phys Lipids 114:45-54. 2002.... - The use of solvent relaxation technique to investigate headgroup hydration and protein binding of simple and mixed phosphatidylcholine/surfactant bilayer membranesK Rieber
IDEA AG, Frankfurter Ring 193 a, 80807 Munich, Germany
Biochim Biophys Acta 1768:1050-8. 2007..Interferon alfa-2b binds to mixed lipid bilayers peripherally, whereas melittin is deeply inserted into lipid membranes and affects their headgroup hydration and mobility measurably... - Coexistence of domains with distinct order and polarity in fluid bacterial membranesSharon Vanounou
Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Photochem Photobiol 76:1-11. 2002..These results suggest a decrease in membrane heterogeneity caused by Cam-induced domain dissipation... - Visualizing membrane microdomains by Laurdan 2-photon microscopyKatharina Gaus
Centre for Vascular Research at the School of Medical Sciences, University of New South Wales and the Department of Haematology, Prince of Wales Hospital, Sydney, Australia
Mol Membr Biol 23:41-8. 2006..Moreover we discuss how microdomains identified by Laurdan microscopy are consistent with domains identified by other methodologies and put GP images in the context of current raft hypotheses... - Phospholipid phase transitions in homogeneous nanometer scale bilayer discsAndrew W Shaw
Department of Chemistry, University of Illinois, Urbana, IL 61801, USA
FEBS Lett 556:260-4. 2004..The broad transition of the Nanodisc lipid bilayer better mimics the phase behavior of cellular membranes than vesicles, making Nanodiscs a 'native-like' lipid environment in which to study membrane associated proteins... - Fluorescence properties of Laurdan in cochleate phasesKarthik Ramani
Department of Pharmaceutical Sciences, 541 Cooke Hall, University at Buffalo, State University of New York, Amherst, NY 14260-1200, USA
Biochim Biophys Acta 1618:67-78. 2003..From these studies, we conclude that Laurdan fluorescence is a sensitive and a rapid method to detect cochleate phase formation... - Divalent cations increase lipid order in erythrocytes and susceptibility to secretory phospholipase A2Rebekah S Vest
Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah 84620, USA
Biophys J 86:2251-60. 2004..These differences appeared related to the ability of the ions to induce a transition in erythrocyte shape... - Fluorescence characteristics of hydrophobic partial agonist probes of the cholecystokinin receptorKaleeckal G Harikumar
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Cancer Center, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
Biosci Rep 26:89-100. 2006..These data suggest that the partially activated conformational state of this receptor is more closely related to its fully active state than to its inactive state... - Time-gated total internal reflection fluorescence spectroscopy (TG-TIRFS): application to the membrane marker laurdanH Schneckenburger
Institut fur Lasertechnologien in der Medizin und Messtechnik an der Universitat Ulm, Ulm, Germany
J Microsc 211:30-6. 2003.... - A two-photon fluorescent probe for lipid raft imaging: C-laurdanHwan Myung Kim
Department of Chemistry and Center for Electro and Photo Responsive Molecules, Korea University, 1 Anamdong, Seoul 136 701, Korea
Chembiochem 8:553-9. 2007..Lipid rafts can be visualized by two-photon microscopy by using C-laurdan as a probe. Our results show that the lipid rafts cover 38 % of the cell surface... - Acrylodan-conjugated cysteine side chains reveal conformational state and ligand site locations of the acetylcholine-binding proteinRyan E Hibbs
Department of Pharmacology, University of California-San Diego, La Jolla, CA 92093-0636, USA
J Biol Chem 279:28483-91. 2004..Labeling at other residue positions around the predicted binding pocket also reveals distinctive spectral changes for alpha-bungarotoxin, agonists, and alkaloid antagonists... - Direct observation of lipid domains in free standing bilayers: from simple to complex lipid mixturesLuis A Bagatolli
Grupo de Biofisica, Departamento de Química Biológica CIQUIBIC, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
Chem Phys Lipids 122:137-45. 2003.... - Use of steady-state laurdan fluorescence to detect changes in liquid ordered phases in human erythrocyte membranesRebekah Vest
Department of Physiology, Brigham Young University, Provo, Utah 84602, USA
J Membr Biol 211:15-25. 2006.... - Kinetic analysis of interdomain coupling in a lidless variant of the molecular chaperone DnaK: DnaK's lid inhibits transition to the low affinity stateSergey V Slepenkov
Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
Biochemistry 41:12224-35. 2002..New evidence in support of the reversible, two-step conformational switch mechanism is also presented... - Use of laurdan fluorescence intensity and polarization to distinguish between changes in membrane fluidity and phospholipid orderFaith M Harris
Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
Biochim Biophys Acta 1565:123-8. 2002..Thus, the same fluorescent probe can be used to distinguish effects of perturbations on membrane order and fluidity by comparing the results of fluorescence emission and anisotropy measurements... - Propofol, a general anesthetic, promotes the formation of fluid phase domains in model membranesSathyamangalam V Balasubramanian
Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, 539 Cooke Hall, Amherst, NY 14260 1200, USA
Chem Phys Lipids 114:35-44. 2002..Based on these studies, we speculate that the mechanism of anesthetic action may involve effects on protein--lipid coupled systems through alterations in small-scale lipid domain structures... - Biochemical basis for enhanced binding of peptide dimers to X-linked inhibitor of apoptosis proteinKathryn E Splan
Department of Chemistry, Macalester College, 1600 Grand Avenue, St Paul, Minnesota 55105, USA
Biochemistry 46:11938-44. 2007.... - Unique effects of different fatty acid species on the physical properties of the torpedo acetylcholine receptor membraneSilvia S Antollini
Instituto de Investigaciones Bioquimicas de Bahia Blanca and UNESCO Chair of Biophysics and Molecular Neurobiology, B8000FWB Bahia Blanca, Argentina
J Biol Chem 277:1249-54. 2002.... 
Subpicosecond transient signal spectroscopy of Prodan in dimethylformamide solutionJános Erostyák
Department of Experimental Physics, University of Pecs, H 7624 Pecs, Ifjúság u 6, Pecs, Hungary
Ann N Y Acad Sci 1130:52-5. 2008..Also, we present calculation of the first spectral moment of this spectral band and estimation of different relaxation components on the subpicosecond time scale...- Effect of pressure on the Prodan fluorescence in bilayer membranes of phospholipids with varying acyl chain lengthsMasataka Kusube
Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2-1 Minamijosanjima, Tokushima 770-8506, Japan
Colloids Surf B Biointerfaces 42:79-88. 2005..The plot of F480/F430 versus pressure is available for recognition of the bilayer phase transitions, especially the bilayer interdigitation... - Influence of spectral heterogeneity of prodan and laurdan solutions on the transfer of electronic energy to octadecyl rhodamine BK A Kozyra
Institute of Experimental Physics, University of Gdansk, Wita Stwosza 57, 80 952 Gdansk, Poland
Biophys Chem 121:57-64. 2006..The relative quenching efficiencies of both dyes depend on polarity of the medium and are higher for more polar solvent (AcN)... - Fluorescence spectroscopic studies of pressure effects on Na+,K(+)-ATPase reconstituted into phospholipid bilayers and model raft mixturesEwa Powalska
Department of Chemistry, Physical Chemistry I, and Biophysical Chemistry, University of Dortmund, Otto Hahn Strasse 6, D 44227 Dortmund, Germany
Biochemistry 46:1672-83. 2007..High pressures, above about 2.2 kbar, irreversibly change protein conformation, probably because of the dissociation and partial unfolding of the subunits... - Differential association of the pleckstrin homology domains of phospholipases C-beta 1, C-beta 2, and C-delta 1 with lipid bilayers and the beta gamma subunits of heterotrimeric G proteinsT Wang
Department of Physiology and Biophysics, State University of New York at Stony Brook 11794 8661, USA
Biochemistry 38:1517-24. 1999..By contrast, docking of the PH domain of PLC-beta2 with G-beta gamma is comparable to that of the full-length protein and may play a key role in G-beta gamma recognition... - Lipid rafts reconstituted in model membranesC Dietrich
Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, 27599, USA
Biophys J 80:1417-28. 2001..Overall, the notion that in biomembranes selected lipids could laterally aggregate to form more ordered, detergent-resistant lipid rafts into which glycosphingolipids partition is strongly supported by this study... - Pressure-induced phase transitions of lipid bilayers observed by fluorescent probes Prodan and LaurdanMasataka Kusube
Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2-1 Minamijosanjima, Tokushima 770-8506, Japan
Biophys Chem 117:199-206. 2005..The plot of F(480)/F(440) versus pressure seems to be useful for the recognition of bilayer phase transition, especially the bilayer interdigitation... - Monitoring the organization and dynamics of bovine hippocampal membranes utilizing Laurdan generalized polarizationSoumi Mukherjee
Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India
Biochim Biophys Acta 1714:43-55. 2005..These results constitute novel information on the dynamics of hippocampal membranes and its modulation by cholesterol depletion monitored using Laurdan fluorescence... - Increased plasma concentrations of palmitoylethanolamide, an endogenous fatty acid amide, affect oxidative damage of human low-density lipoproteins: an in vitro studyGiovanna Zolese
Istituto di Biochimica, Via Ranieri 65, Universita Politecnica delle Marche, Ancona 60131, Italy
Atherosclerosis 182:47-55. 2005..1 microM), while the pro-oxidative effect is obtained at a higher PEA concentration (1 microM). Fluorescence and circular dichroism data indicate that the effect of PEA occurs mainly by affecting the conformational features of ApoB-100... - Oleoylethanolamide protects human sperm cells from oxidation stress: studies on cases of idiopathic infertilityAnnarina Ambrosini
Institute of Biochemistry, Polytechnic University of Marche, 60100 Ancona, Italy
Biol Reprod 74:659-65. 2006..Results of this study support the hypothesis of a possible protective action of oleoylethanolamide against reactive oxygen species, which could explain its beneficial effects on in vitro capacitated spermatozoa... - Microfluorometry of cell membrane dynamicsPetra Weber
Hochschule Aalen, , 73430 Aalen, Germany
Cytometry A 69:185-8. 2006..Spectral properties are evaluated and displayed as microscopic images... - Phase transition affects energy transfer efficiency in phospholipid vesiclesK A Kozyra
Institute of Experimental Physics, University of Gdansk, ul Wita Stwosza 57, Gdansk, Poland
Spectrochim Acta A Mol Biomol Spectrosc 61:1153-61. 2005..The relative quenching efficiencies of both dyes depend on the phase state of the bilayer and indicate a deeper incorporation of PRODAN and LAURDAN into the membrane in its fluid phase than in its gel phase... - Preparation, stability, and in vitro performance of vesicles made with diblock copolymersJ C Lee
School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA
Biotechnol Bioeng 73:135-45. 2001..The results potentiate a broad new class of technologically useful, polymer-based vesicles... - Fluorescence detection of signs of sterol superlattice formation in lipid membranesParkson Lee Gau Chong
Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA
Methods Mol Biol 400:159-70. 2007..The principles and methodologies described here can be extended to other probes or bioactive molecules, such as enzymes, and can be applied to study sterol lateral organization in multicomponent lipid membranes... - Metal ion-independent association of factor VIII subunits and the roles of calcium and copper ions for cofactor activity and inter-subunit affinityH Wakabayashi
Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York 14642, USA
Biochemistry 40:10293-300. 2001..Ca(2+) appears essential to promote the active conformation of factor VIII while Cu(2+) primarily enhances the intersubunit affinity... - Fluorescence studies of the interactions of ubiquinol-10 with liposomesRosamaria Fiorini
Biochemistry Institute, Marche Polytechnic University, Ancona, Italy
Photochem Photobiol 84:209-14. 2008..The results indicate that ubiquinol-10 molecules are mainly located at the polar-lipid interface, inducing changes in the physico-chemical properties of the bilayer microenvironment... - Loss of apoB-100 secondary structure and conformation in hydroperoxide rich, electronegative LDL(-)T Parasassi
Istituto di Medicina Sperimentale, CNR, Roma, Italy
Free Radic Biol Med 31:82-9. 2001..The looser monolayer packing apparently favors the new conformation of apoB-100 and its sinking into a more hydrophobic environment, possibly accounting for it reduced receptor binding properties... - Mitochondrial creatine kinase binding to phospholipids decreases fluidity of membranes and promotes new lipid-induced beta structures as monitored by red edge excitation shift, laurdan fluorescence, and FTIRT Granjon
, , , 69622 Villeurbanne Cedex, France
Biochemistry 40:6016-26. 2001.... - Trifluoperazine induces domain formation in zwitterionic phosphatidylcholine but not in charged phosphatidylglycerol bilayersA B Hendrich
Department of Biophysics, Wroclaw Medical University, ul. Chalubinskiego 10, 50-368, Wroclaw, Poland
Biochim Biophys Acta 1510:414-25. 2001..This may partially explain the mechanism of multidrug resistance modulation by trifluoperazine... - Temperature and pressure effects on structural and conformational properties of POPC/SM/cholesterol model raft mixtures--a FT-IR, SAXS, DSC, PPC and Laurdan fluorescence spectroscopy studyChiara Nicolini
University of Dortmund, Department of Chemistry, Physical Chemistry I-Biophysical Chemistry, Otto-Hahn-Strasse 6, D-44227 Dortmund, Germany
Biochim Biophys Acta 1758:248-58. 2006..Interestingly, in this pressure range, ceasing of membrane protein function in natural membrane environments has been observed for a variety of systems... - Surface properties of cholesterol-containing membranes detected by Prodan fluorescenceE K Krasnowska
Istituto di Neurobiologia e Medicina Molecolare, CNR, Viale Marx 15-43, 00137 Rome, Italy
Biochim Biophys Acta 1511:330-40. 2001.... - Erythrocyte plasma membrane perturbations in rats fed a cholesterol-rich diet: effect of drinking sulphurous mineral waterCinzia Nasuti
Dottorato di Ricerca in Invecchiamento e Nutrizione, , Camerino, Italy
Ann Nutr Metab 49:9-15. 2005..CONCLUSION: Hydropinic treatment with SMW is of interest from the biomedical point of view, because it could represent an alternative approach in interventions aimed at ameliorating biological injury deriving from hypercholesterolaemia... - Effect-directed analysis of key toxicants in European river basins a reviewWerner Brack
UFZ Centre for Environmental Research, Department of Effect Directed Analysis, Leipzig, Germany
Environ Sci Pollut Res Int 14:30-8. 2007..Thus, one focus of present European research is on toxicant identification in European river basins in order to allow for a reduction of toxic pressure on aquatic ecosystems according to the WFD... - Performance of 181 chemicals in a Drosophila assay predominantly monitoring interchromosomal mitotic recombinationE W Vogel
Department of Radiation Genetics and Chemical Mutagenesis, Leiden, Netherlands
Mutagenesis 8:57-81. 1993..Their weak responses were always accompanied by signs of toxicity.(ABSTRACT TRUNCATED AT 400 WORDS).. - Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylaminesM A Butler
Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079
Proc Natl Acad Sci U S A 86:7696-700. 1989.... - Cathepsin activities and membrane integrity of zebrafish (Danio rerio) oocytes after freezing to -196 degrees C using controlled slow coolingT Zhang
Institute of Research in the Applied Natural Sciences, University of Bedfordshire, The Spires, 2 Adelaide Street, Luton, Bedfordshire LU1 5DU, UK
Cryobiology 56:138-43. 2008..8% stayed intact after freezing in DMSO and methanol to -196 degrees C. The results indicate that cryoprotectant treatment and freezing modified the activities of lysosomal enzymes involved in oocyte maturation and yolk mobilisation... - Mutagenicity of aromatic amines and amides with chemical models for cytochrome P450 in Ames assayKeiko Inami
Kyoritsu University of Pharmacy, Tokyo 105 8512, Japan
Toxicol In Vitro 23:986-91. 2009..Furthermore, we concluded that the AAF mutagenicity in the presence of 4-MPy/t-BuOOH is derived from N-hydroxylacetylamino compounds... - Fatty acids and glucose increase neutral endopeptidase activity in human microvascular endothelial cellsPornprom Muangman
University of Washington, Department of Surgery, Harborview Medical Center, Seattle, Washington 98104, USA
Shock 19:508-12. 2003..with glutaryl-Ala-Ala-Phe-4-methoxy-beta naphthylamide to generate a fluorescent degradation product methoxy 2 naphthylamine. High glucose or fatty acid concentration upregulated NEP activity... - Chemometric-assisted MIP-optosensing system for the simultaneous determination of monoamine naphthalenes in drinking watersAngel Valero-Navarro
Department of Analytical Chemistry, University of Granada, Granada, Spain
Talanta 78:57-65. 2009..Predictive ability, accuracy, figures of merit, as well as advantages and disadvantages of the different strategies were discussed... - The development of a MIP-optosensor for the detection of monoamine naphthalenes in drinking waterAngel Valero-Navarro
Department of Analytical Chemistry, University of Granada, c Fuentenueva s n, 18071 Granada, Spain
Biosens Bioelectron 24:2305-11. 2009..Finally, we applied it to the analysis of 1-NA and 2-NA in tap and mineral waters, obtaining a 98% average recovery rate... - Glycolipid transfer protein interaction with bilayer vesicles: modulation by changing lipid compositionChetan S Rao
University of Minnesota, Hormel Institute, Austin, Minnesota 55912, USA
Biophys J 89:4017-28. 2005..A model of GLTP interaction with the membrane, based on the partitioning equilibrium data and consistent with the kinetics of GSL transfer, is presented and solved mathematically... - Anchoring metabolic changes to phenotypic effects in the chlorophyte Scenedesmus vacuolatus under chemical exposureFrédéric Sans-Piché
Department of Bioanalytical Ecotoxicology, UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
Mar Environ Res 69:S28-30. 2010.... - Assessment of the performance of the Ames II assay: a collaborative study with 19 coded compoundsS Flückiger-Isler
Xenometrix by Endotell GmbH, CH 4125 Allschwil, Switzerland
Mutat Res 558:181-97. 2004.... - Impairment of telomeric quadruple helix formation - A possible event involved in the carcinogenicity of aromatic amines from the thermodynamic point of view?Sven Gunia
Institute of Pathology, HELIOS Klinikum Bad Saarow, Charité University Medicine Teaching Hospital, Pieskower Strasse 33, 15526 Bad Saarow, Germany
Med Hypotheses 75:123-5. 2010.... - Variation in enzymes of arylamine procarcinogen biotransformation among bladder cancer patients and control subjectsS A Vaziri
Genetics and Genomnic Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Canada
Pharmacogenetics 11:7-20. 2001..arylamine procarcinogens in theory, interindividual variations in CYP1A2, NAT1 and NAT2 activities do not significantly differ between bladder cancer patients and control subjects when potential arylamine exposures are controlled for.. - The practical synthesis of (2S)-7-methoxy-1,2,3,4-tetrahydro-2-naphthylamine via optical resolution of 2-(3-methoxybenzyl)succinic acidT Yanagi
Central Research Laboratories, Kissei Pharmaceutical Co, Ltd, Minamiazumi, Nagano, Japan
Chem Pharm Bull (Tokyo) 49:340-4. 2001..S)-AMT was obtained from the acid (S)-2 by Hofmann rearrangement without racemization... - Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterizationYoichi Sakakibara
Biomedical Research Center, The University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708, USA
Gene 285:39-47. 2002..Using mouse brain filtrate as substrate, both brain sulfotransferases were shown to catalyze specifically the sulfation of only a few compounds... - Flow cytometry as a tool to study phytotoxic modes of actionNicole E Adler
Umweltforschungszentrum UFZ Centre for Environmental Research Leipzig Halle, Department Bioanalytical Ecotoxicology, Permoserstrasse 15, 04318 Leipzig, Germany
Environ Toxicol Chem 26:297-306. 2007.... - Inclusion complex of 2-naphthylamine-6-sulfonate with beta-cyclodextrin: intramolecular charge transfer versus hydrogen bonding effectsAyman Ayoub Abdel-Shafi
Department of Chemistry, Faculty of Science, Ain Shams University, 11566 Abbassia, Cairo, Egypt
Spectrochim Acta A Mol Biomol Spectrosc 66:1228-36. 2007.... - Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosaS Imaoka
Laboratory of Chemistry, Osaka City University Medical School, Osaka, Japan
Biochem Pharmacol 54:677-83. 1997..These findings suggested that CYP4B1 could contribute to the initiation of carcinogenesis in rat and mouse bladder by activation of aromatic amines... - Analysis of aromatic amines in cigarette smokeRegina Stabbert
Philip Morris Research Laboratories GmbH, Fuggerstr 3, D 51149 Köln, Germany
Rapid Commun Mass Spectrom 17:2125-32. 2003..The results support the hypothesis that the nitrogen content of the tobacco, and above all the cigarette combustion temperature, are determining factors for the yields of aromatic amines in smoke... - Androgen regulation of CYP4B1 responsible for mutagenic activation of bladder carcinogens in the rat bladder: detection of CYP4B1 mRNA by competitive reverse transcription-polymerase chain reactionS Imaoka
Department of Chemical Biology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, 545 8585, Osaka, Japan
Cancer Lett 166:119-23. 2001..Furthermore, the present findings suggest that the sex difference observed in bladder carcinogenesis was due to sex-different expression of CYP4B1 in bladder tissue... - Possible relationship between the risk of Japanese bladder cancer cases and the CYP4B1 genotypeTakamitsu Sasaki
Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University, Sendai 981 8558, Japan
Jpn J Clin Oncol 38:634-40. 2008..We demonstrated the first genetic study regarding the association of CYP4B1 with bladder cancer. Our results suggest that CYP4B1 genotypes might have an effect on the risk of bladder cancer... - Percutaneous absorption of aromatic amines - a contribution for human health risk assessmentT Wellner
Institute and Out Patient Clinic of Occupational, Social and Environmental Medicine, University Erlangen Nuremberg, Schillerstrasse 25 29, D 91054 Erlangen, Germany
Food Chem Toxicol 46:1960-8. 2008..The in vitro data support our recent findings in rubber industry workers that the percutaneous absorption may significantly contribute to overall exposure of AA... - NAT2 slow acetylation and bladder cancer in workers exposed to benzidineTania Carreon
Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA
Int J Cancer 118:161-8. 2006..Study findings suggest the existence of key differences in the metabolism of mono- and diarylamines... - 2-Naphthol levels and genotoxicity in rubber workersGlenn Talaska
Department of Environmental Health, University of Cincinnati College of Medicine, 3223 Eden Ave, Cincinnati, OH 45267 0056, USA
Toxicol Lett 213:45-8. 2012..However, the differences were not significantly different overall and urinary 2NAP levels did not predict the level of carcinogen DNA adducts in exfoliated urothelial cells... - Bladder cancer in crack testers applying azo dye-based sprays to metal bodiesKlaus Golka
Leibniz Research Centre for Working Environment and Human Factors IfADo, Dortmund, Germany
J Toxicol Environ Health A 75:566-71. 2012..Bladder cancer patients with metal-related jobs need to be explicitly asked about the use of crack test sprays... - Chain asymmetry alters thermotropic and barotropic properties of phospholipid bilayer membranesMasaki Goto
Department of Life System, Institute of Technology and Science, The University of Tokushima, 2 1 Minamijosanjima cho, Tokushima 770 8506, Japan
Chem Phys Lipids 161:65-76. 2009..chain-length inequivalence parameter plot, where the effect was proved to be classified in three zones depending on the alignment of both terminal methyl ends... - Solvation dynamics of the fluorescent probe PRODAN in heterogeneous environments: contributions from the locally excited and charge-transferred statesRamkrishna Adhikary
Department of Chemistry, Iowa State University, Ames, Iowa 50011 3111, USA
J Phys Chem B 113:11999-2004. 2009.... - Denaturation studies of active-site labeled papain using electron paramagnetic resonance and fluorescence spectroscopyZ A Ping
Department of Chemistry, University of Kentucky, Lexington 40506 0055
Biophys J 60:623-8. 1991..These results strongly suggest that SL-PMB and Acrylodan labels can be used to characterize the physical state of the active site of the enzyme... - Interaction of alpha-tocopherol with model human high-density lipoproteinsJ B Massey
Department of Medicine, Baylor College of Medicine and The Methodist Hospital, Houston, Texas 77030 USA
Biophys J 75:2923-31. 1998.... - Fluorometric determination of nitrite with 2,3-diaminonaphthalene by reverse phase HPLC under alkaline conditionsYang Il Fang
Department of Pharmacology, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
J Pharmacol Toxicol Methods 59:153-5. 2009..In this study, a simple and sensitive fluorometric HPLC method was described for the determination of nitrite, an indicator of nitric oxide production in biological samples... - Glycan tagging to produce bioactive ligands for a surface plasmon resonance study via immobilization on different surfacesF Javier Muñoz
Departamento de Quimica Organica y Farmaceutica, Universidad Complutense de Madrid, Spain
Bioconjug Chem 20:673-82. 2009.... - Arylamine N-acetyltransferase activity in bronchial epithelial cells and its inhibition by cellular oxidantsJulien Dairou
Univ Paris Diderot Paris 7, Unit of Functional and Adaptative Biology BFA affiliated with CNRS, Laboratory of Molecular and Cellular Responses to Xenobiotics, Paris, France
Toxicol Appl Pharmacol 236:366-71. 2009.... - Effect-directed analysis of sediment-associated algal toxicants at selected hot spots in the river Elbe basin with a special focus on bioaccessibilityKatrin Schwab
Department of Effect Directed Analysis, UFZ Helmholtz Centre for Environmental Research, Permoser Str 15, D 04318 Leipzig, Germany
Environ Toxicol Chem 28:1506-17. 2009..The extraction with TENAX with a subsequent EDA proved to be a powerful tool for prioritizing contaminants and contaminated sites with respect to the hazard of sediment-associated toxicants to green algae... - Mechanical and chemical properties of cysteine-modified kinesin moleculesS Iwatani
Department of Biophysical Engineering, Osaka University, Japan
Biochemistry 38:10318-23. 1999..This step size was close to a unitary step size of 8 nm. Thus, the mechanical events of kinesin are tightly coupled with the chemical events... - A model for the interaction of 6-lauroyl-2-(N,N-dimethylamino)naphthalene with lipid environments: implications for spectral propertiesL A Bagatolli
Laboratory for Fluorescence Dynamics, University of Illinois at Urbana Champaign 61801, USA
Photochem Photobiol 70:557-64. 1999..In the context of variable excitation wavelengths, information concerning solvent dipolar relaxation through excitation generalized polarization function is also discussed... - Small molecule activators of pre-mRNA 3' cleavageKevin Ryan
Department of Chemistry and Biochemistry, City College of New York, New York, New York 10031, USA
RNA 15:483-92. 2009.... - The effect of detergents on trimeric G-protein activity in isolated plasma membranes from rat brain cortex: correlation with studies of DPH and Laurdan fluorescenceJ Sykora
J Heyrovsky Institute of Physical Chemistry of the ASCR, v v i, Dolejskova 2155 3, 18223 Prague 8, Czech Republic
Biochim Biophys Acta 1788:324-32. 2009..As before, the effect of detergents on GP parameters proceeded in the order: Brij58>Triton X-100>Digitonin... - Influence of cations on noncovalent interactions between 6-propionyl-2-dimethylaminonaphthalene (PRODAN) and dissolved fulvic and humic acidsPraveen Gadad
School of Civil Engineering and Environmental Science, College of Engineering, University of Oklahoma, Norman, Oklahoma 73019, U S
Water Res 42:4818-26. 2008.... - Synthesis and evaluation of dimeric 1,2,3,4-tetrahydro-naphthalenylamine and indan-1-ylamine derivatives with mast cell-stabilising and anti-allergic activityJames W Barlow
Department of Pharmacognosy, School of Pharmacy, University of Dublin, Trinity College, Dublin 2, Ireland
Eur J Med Chem 45:25-37. 2010..Of these derivatives, the most promising activity was seen with tertiary amine 58a, which exhibited potent mast cell-stabilising activity in vitro against a variety of stimuli and also in vivo against passive cutaneous anaphylaxis... - Migrating human neutrophils exhibit dynamic spatiotemporal variation in membrane lipid organizationRobert G Sitrin
Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Am J Respir Cell Mol Biol 43:498-506. 2010..These findings solidify the existence of rapidly reorganizing LRMs in situ and support a role for LRMs in chemotaxin responsiveness... - Molecular cloning and expression of an amine sulfotransferase cDNA: a new gene family of cytosolic sulfotransferases in mammalsK Yoshinari
Division of Drug Metabolism and Molecular Toxicology, Faculty of Pharmaceutical Sciences, Tohoku University, Aramaki Aoba, Aoba ku, Sendai 980 8578, Japan
J Biochem 123:479-86. 1998.... - Effect of tobacco compounds on gene expression profiles in human epithelial cellsSung Hwa Sohn
Department of Physiology, College of Oriental Medicine, Kyung Hee University, Seoul 130 701, Republic of Korea
Environ Toxicol Pharmacol 27:111-9. 2009..Also, our study demonstrates that a microarray-based genomic survey is a suitable high-throughput approach for the evaluation of gene expression and for the characterization of TC-induced toxicity... - Identification of mutagens in freshwater sediments by the Ames-fluctuation assay using nitroreductase and acetyltransferase overproducing test strainsGeorg Reifferscheid
Division of Qualitative Hydrology, German Federal Institute of Hydrology BfG, Am Mainzer Tor 1, Koblenz 56068, Germany
Environ Mol Mutagen 52:397-408. 2011..In fact, a number of heterocyclic and nitrogen-substituted aromatic compounds were identified in the sediments of the Spittelwasser creek of which methyl parathion, 1-naphthylamine, and N-phenyl-2-naphthylamine are mutagenic... - Comparison of exposure to selected cigarette smoke constituents in adult smokers and nonsmokers in a European, multicenter, observational studyDirk Lindner
Philip Morris International R and D, Philip Morris Products S A, Neuchatel, Switzerland
Cancer Epidemiol Biomarkers Prev 20:1524-36. 2011.... - Biochemical comparison of proteolytic enzymes present in rough- and smooth-surfaced capnocytophagas isolated from the subgingival plaque of periodontitis patientsE Soderling
Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor
J Periodontal Res 26:17-23. 1991.... - The possible involvement of dopamine D3 receptors in the regulation of gastric emptying in ratsTakashi Yoshikawa
Strategic Planning and Business Development Division, Dainippon Sumitomo Pharma Co, Ltd Osaka, Japan
Life Sci 87:638-42. 2010..The aim of this study was to investigate the possible involvement of the dopamine D(3) receptor in the regulation of gastric motility in rats using selective dopamine D(3) receptor agonists or a dopamine D(3) receptor antagonist... - Effect of vesicle size on the prodan fluorescence in diheptadecanoylphosphatidylcholine bilayer membrane under atmospheric and high pressuresMasaki Goto
Department of Life System, Institute of Technology and Science, University of Tokushima, 2 1 Minamijosanjima cho, Tokushima 770 8506, Japan
Langmuir 26:13377-84. 2010.... - α- and β-crystallins modulate the head group order of human lens membranes during agingXiangjia Zhu
Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
Invest Ophthalmol Vis Sci 51:5162-7. 2010..To examine the physical properties of human lens cell membranes as a function of age...
Research Grants
- DNA ADDUCTS OF AROMATIC AMINES--ANALYSIS BY MS AND P-32Paul Vouros; Fiscal Year: 2002..It is expected that this program will lead to the establishment of a rigorous mass spectrometric methodology for the study of DNA adducts and the use of biomarkers for risk assessment. ..
- Lipid Raft Microdomains in Neutrophil FunctionRobert Sitrin; Fiscal Year: 2007..Hopefully, targeting the function of lipid raft microdomains will engender new therapeutic strategies for enhancing antimicrobial defenses and suppressing the deleterious effects of acute inflammation. ..
- New Coding Vectors for microRNA and siRNAKevin Ryan; Fiscal Year: 2006..abstract_text> ..
- Development and Pharmacology of Novel Lipidic rAHFSathy Balu Iyer; Fiscal Year: 2007..The results obtained from these studies will be useful to develop optimal dosing and efficient management of the disease and therapy. ..
- Development and Pharmacology of Novel Lipidic rAHFSATHY VENKAT BALU IYER; Fiscal Year: 2010..The results obtained from these studies will be useful to develop optimal dosing and efficient management of the disease and therapy. ..
- Development and Pharmacology of Novel Lipidic rAHFSathy Balu Iyer; Fiscal Year: 2005..We also propose to study the epitope specificity of rAHF antibodies and the mechanism of immune response. ..
- The Urokinase-CD87 System in Macrophage ActivationRobert Sitrin; Fiscal Year: 2004....
- UROKINASE CD87 SYSTEM IN MACROPHAGE ACTIVATIONRobert Sitrin; Fiscal Year: 1999....
- Lipid Raft Microdomains in Neutrophil FunctionROBERT GARY SITRIN; Fiscal Year: 2010..Hopefully, targeting the function of lipid raft microdomains will engender new therapeutic strategies for enhancing antimicrobial defenses and suppressing the deleterious effects of acute inflammation. ..