sulfamethoxazole

Summary

Summary: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)

Top Publications

  1. ncbi Pharmaceutical retention mechanisms by nanofiltration membranes
    Long D Nghiem
    Environmental Engineering, University of Wollongong, New South Wales 2522, Australia
    Environ Sci Technol 39:7698-705. 2005
  2. ncbi Effects of the antimicrobial sulfamethoxazole on groundwater bacterial enrichment
    Jennifer C Underwood
    United States Geological Survey, 3215 Marine Street, Boulder, Colorado 80303, USA
    Environ Sci Technol 45:3096-101. 2011
  3. ncbi Comparison of the pharmacokinetics of sulfamethoxazole in male chinese volunteers at low altitude and acute exposure to high altitude versus subjects living chronically at high altitude: an open-label, controlled, prospective study
    Xiang Yang Li
    Department of Pharmacology, College of Life Science, Shenyang Pharmaceutical University, Shenyang, China
    Clin Ther 31:2744-54. 2009
  4. ncbi Cross-reactivity in drug hypersensitivity reactions to sulfasalazine and sulfamethoxazole
    Anna Zawodniak
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, Bern, Switzerland
    Int Arch Allergy Immunol 153:152-6. 2010
  5. ncbi Non-covalent presentation of sulfamethoxazole to human CD4+ T cells is independent of distinct human leucocyte antigen-bound peptides
    C Burkhart
    Clinic of Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern, Switzerland
    Clin Exp Allergy 32:1635-43. 2002
  6. ncbi Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells
    C Burkhart
    Clinic of Rheumatology and Clinical Immunology Allergology, Inselspital, 3010 Bern, Switzerland
    Br J Pharmacol 132:623-30. 2001
  7. ncbi Analysis of Pneumocystis jirovecii DHPS alleles implicated in sulfamethoxazole resistance using an Escherichia coli model system
    Peter Iliades
    CSIRO Health Sciences and Nutrition, Parkville, Victoria, 3052, Australia
    Microb Drug Resist 11:1-8. 2005
  8. ncbi Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia
    J Helweg-Larsen
    Department of Infectious Diseases, University of Copenhagen, Hvidovre Hospital, Denmark
    Lancet 354:1347-51. 1999
  9. ncbi Novel non-labile covalent binding of sulfamethoxazole reactive metabolites to cultured human lymphoid cells
    Mukesh Summan
    Laboratory of Comparative Pharmacogenetics, Atlantic Veterinary College, PEI Health Research Institute, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island, Canada, C1A 4P3
    Chem Biol Interact 142:155-73. 2002
  10. ncbi The role of horizontal gene transfer in the spread of trimethoprim-sulfamethoxazole resistance among uropathogenic Escherichia coli in Europe and Canada
    Matthew T Blahna
    Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, 48109, USA
    J Antimicrob Chemother 57:666-72. 2006

Research Grants

  1. Cranberry: Interactions with Anti-infectious Agents
    Gail Anderson; Fiscal Year: 2005
  2. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2003
  3. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2007
  4. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2009
  5. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
  6. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2007
  7. Epidemic CA-MRSA: Molecular Epidemiology and Immunology
    ROBERT S contact DAUM; Fiscal Year: 2010
  8. Structural Studies of AIDS-Responsive Drugs
    Vivian Cody; Fiscal Year: 2007
  9. Structural Studies of AIDS-Responsive Drugs
    Vivian Cody; Fiscal Year: 2010
  10. S-Adenosylmethionine and Pneumocystis treatment
    Salim Merali; Fiscal Year: 2007

Detail Information

Publications191 found, 100 shown here

  1. ncbi Pharmaceutical retention mechanisms by nanofiltration membranes
    Long D Nghiem
    Environmental Engineering, University of Wollongong, New South Wales 2522, Australia
    Environ Sci Technol 39:7698-705. 2005
    This study investigates the retention mechanisms of three pharmaceuticals-sulfamethoxazole, carbamazepine, and ibuprofen-by nanofiltration (NF) membranes...
  2. ncbi Effects of the antimicrobial sulfamethoxazole on groundwater bacterial enrichment
    Jennifer C Underwood
    United States Geological Survey, 3215 Marine Street, Boulder, Colorado 80303, USA
    Environ Sci Technol 45:3096-101. 2011
    The effects of "trace" (environmentally relevant) concentrations of the antimicrobial agent sulfamethoxazole (SMX) on the growth, nitrate reduction activity, and bacterial composition of an enrichment culture prepared with ..
  3. ncbi Comparison of the pharmacokinetics of sulfamethoxazole in male chinese volunteers at low altitude and acute exposure to high altitude versus subjects living chronically at high altitude: an open-label, controlled, prospective study
    Xiang Yang Li
    Department of Pharmacology, College of Life Science, Shenyang Pharmaceutical University, Shenyang, China
    Clin Ther 31:2744-54. 2009
    b>Sulfamethoxazole is an antibacterial sulfonamide used primarily for the treatment of a wide variety of bacterial infections in combination with trimethoprim...
  4. ncbi Cross-reactivity in drug hypersensitivity reactions to sulfasalazine and sulfamethoxazole
    Anna Zawodniak
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, Bern, Switzerland
    Int Arch Allergy Immunol 153:152-6. 2010
    ..Therefore, we aimed to analyze in vitro the cross-reactivity between the antimicrobial sulfamethoxazole and the anti-inflammatory drug sulfasalazine.
  5. ncbi Non-covalent presentation of sulfamethoxazole to human CD4+ T cells is independent of distinct human leucocyte antigen-bound peptides
    C Burkhart
    Clinic of Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern, Switzerland
    Clin Exp Allergy 32:1635-43. 2002
    ..processing- and metabolism-independent pathway for the presentation of allergenic drugs such as lidocaine and sulfamethoxazole (SMX) to drug-specific T cells...
  6. ncbi Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells
    C Burkhart
    Clinic of Rheumatology and Clinical Immunology Allergology, Inselspital, 3010 Bern, Switzerland
    Br J Pharmacol 132:623-30. 2001
    1. Hypersensitivity to the drug sulfamethoxazole (SMX) is thought to be a consequence of bioactivation to the hydroxylamine metabolite (SMX-NHOH) and further oxidation to the ultimate reactive metabolite, nitroso-sulfamethoxazole (SMX-NO)...
  7. ncbi Analysis of Pneumocystis jirovecii DHPS alleles implicated in sulfamethoxazole resistance using an Escherichia coli model system
    Peter Iliades
    CSIRO Health Sciences and Nutrition, Parkville, Victoria, 3052, Australia
    Microb Drug Resist 11:1-8. 2005
    ..Two sulfa drugs (sulfachloropyridazine and sulfathiazole) were identified that had higher inhibitory potential than sulfamethoxazole, which is currently the preferred treatment for PCP.
  8. ncbi Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia
    J Helweg-Larsen
    Department of Infectious Diseases, University of Copenhagen, Hvidovre Hospital, Denmark
    Lancet 354:1347-51. 1999
    ..We assessed whether mutations in the DHPS gene of P. carinii were associated with exposure to sulpha drugs and influenced outcome from PCP...
  9. ncbi Novel non-labile covalent binding of sulfamethoxazole reactive metabolites to cultured human lymphoid cells
    Mukesh Summan
    Laboratory of Comparative Pharmacogenetics, Atlantic Veterinary College, PEI Health Research Institute, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island, Canada, C1A 4P3
    Chem Biol Interact 142:155-73. 2002
    b>Sulfamethoxazole (SMX) causes rare hypersensitivity syndrome reactions characterized by fever and multi-organ toxicity...
  10. ncbi The role of horizontal gene transfer in the spread of trimethoprim-sulfamethoxazole resistance among uropathogenic Escherichia coli in Europe and Canada
    Matthew T Blahna
    Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, 48109, USA
    J Antimicrob Chemother 57:666-72. 2006
    OBJECTIVES: To describe the distribution of trimethoprim-sulfamethoxazole resistance genes and the role of horizontal gene transfer and clonal expansion in recent increases of antibiotic resistance rates among uropathogenic Escherichia ..
  11. ncbi Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole: an increasing problem
    Asma Marzouq Al-Jasser
    Department of Microbiology, Armed Forces Hospital, Box X 966, P O Box 7897, Riyadh 11159, Saudi Arabia
    Ann Clin Microbiol Antimicrob 5:23. 2006
    ..Trimethoprim-sulfamethoxazole (TMP - SXT) is recommended as the agent of choice for the treatment of S. maltophilia infections...
  12. ncbi On the occasional biodegradation of pharmaceuticals in the activated sludge process: the example of the antibiotic sulfamethoxazole
    P Drillia
    Department of Chemical Engineering, University of Patras, Greece
    J Hazard Mater 122:259-65. 2005
    b>Sulfamethoxazole, a common antibiotic, was found to be biodegradable under aerobic conditions. The fate of sulfamethoxazole in the activated sludge process was studied using a Sequencing Batch Reactor (SBR)...
  13. ncbi Dihydropteroate synthase mutations in Pneumocystis jiroveci can affect sulfamethoxazole resistance in a Saccharomyces cerevisiae model
    Peter Iliades
    CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Antimicrob Agents Chemother 48:2617-23. 2004
    ..synthase (DHPS) mutations in Pneumocystis jiroveci have been associated epidemiologically with resistance to sulfamethoxazole (SMX). Since P. jiroveci cannot be cultured, inherent drug resistance cannot be measured...
  14. ncbi Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively
    Xia Wen
    Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Drug Metab Dispos 30:631-5. 2002
    To evaluate the inhibitory effects of trimethoprim and sulfamethoxazole on cytochrome P450 (P450) isoforms, selective marker reactions for CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 were examined in human liver ..
  15. ncbi Cloning and molecular characterization of three arylamine N-acetyltransferase genes from Bacillus anthracis: identification of unusual enzymatic properties and their contribution to sulfamethoxazole resistance
    Benjamin Pluvinage
    Laboratoire de Cytophysiologie et Toxicologie Cellulaire, EA 1553, Universite Paris 7 Denis Diderot, 75005 Paris, France
    Biochemistry 46:7069-78. 2007
    ..displayed strong NAT activity toward several prototypic NAT substrates, including the sulfonamide antibiotic sulfamethoxazole (SMX)...
  16. ncbi Dosing regimens of cotrimoxazole (trimethoprim-sulfamethoxazole) for melioidosis
    Allen C Cheng
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Antimicrob Agents Chemother 53:4193-9. 2009
    ..PK) simulation study was performed to determine the optimal dosing of cotrimoxazole (trimethoprim-sulfamethoxazole [TMP-SMX]) used in current eradication regimens in Thailand and Australia...
  17. ncbi Dihydrofolate reductase and dihydropteroate synthase genotypes associated with in vitro resistance of Plasmodium falciparum to pyrimethamine, trimethoprim, sulfadoxine, and sulfamethoxazole
    Insaf Khalil
    Center for Medical Parasitology, Institute of Medical Microbiology and Immunology, University of Copenhagen, Panum Institute, Denmark
    Am J Trop Med Hyg 68:586-9. 2003
    ..isolates were tested in vitro against pyrimethamine (PYR), trimethoprim (TRM), sulfadoxine (SDX), and sulfamethoxazole (SMX), and their dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genotypes were determined...
  18. ncbi Comparison of short-term treatment regimen of ciprofloxacin versus long-term treatment regimens of trimethoprim/sulfamethoxazole or norfloxacin for uncomplicated lower urinary tract infections: a randomized, multicentre, open-label, prospective study
    José Luis Arredondo-García
    Instituto Nacional de Perinatologia, Mexico City, Mexico
    J Antimicrob Chemother 54:840-3. 2004
    ..uncomplicated cystitis in ambulatory pre-menopausal women: ciprofloxacin 250 mg orally twice daily for 3 days, trimethoprim/sulfamethoxazole 160/800 mg orally twice daily for 7 days, and norfloxacin 400 mg orally twice daily for 7 days.
  19. ncbi Prevalence and predictors of trimethoprim-sulfamethoxazole resistance among uropathogenic Escherichia coli isolates in Michigan
    Patricia D Brown
    Division of Infectious Diseases, Department of Internal Medicine, Wayne State University, School of Medicine, Detroit, MI, USA
    Clin Infect Dis 34:1061-6. 2002
    Resistance among uropathogenic Escherichia coli to trimethoprim-sulfamethoxazole (TMP-SMX) has increased. Risk factors for resistance and the impact on clinical failure have been poorly described...
  20. ncbi In vitro activity of caspofungin combined with sulfamethoxazole against clinical isolates of Aspergillus spp
    Aya Yekutiel
    Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Ramat-Aviv 69978, Tel-Aviv, Israel
    Antimicrob Agents Chemother 48:3279-83. 2004
    Caspofungin (CAS) inhibits fungal cell wall synthesis. Sulfamethoxazole (SMX) inhibits folate biosynthesis and is active in vitro against Aspergillus spp...
  21. ncbi Continuous on-line concentration based on dynamic pH junction for trimethoprim and sulfamethoxazole by microfluidic capillary electrophoresis combined with flow injection analysis system
    Liuyin Fan
    Department of Chemistry, Lanzhou University, Lanzhou, Gansu Province 730000, PR China
    J Chromatogr A 1062:133-7. 2005
    ..on-line concentration approach based on dynamic pH junction for the analysis of trimethoprim (TMP) and sulfamethoxazole (SMZ) by microfluidic capillary electrophoresis (CE) combined with flow injection analysis is developed in ..
  22. ncbi Attempts to eradicate methicillin-resistant Staphylococcus aureus colonization with the use of trimethoprim-sulfamethoxazole, rifampin, and bacitracin
    J S Roccaforte
    Medical Services, Veterans Administration Medical Center, Omaha, NE 68105
    Am J Infect Control 16:141-6. 1988
    ..9 antibiotics preceded the first MRSA culture. The usual regimen (mean, 6.0 days) was oral trimethoprim-sulfamethoxazole, 160/800 mg twice daily, oral rifampin, 600 mg once daily, and bacitracin ointment three times a day...
  23. ncbi The Escherichia coli mazEF suicide module mediates thymineless death
    Boaz Sat
    Department of Molecular Biology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Bacteriol 185:1803-7. 2003
    ..Our results, which describe thymine starvation as a trigger for a built-in death program, have implications for programmed cell death in both prokaryotes and eukaryotes...
  24. ncbi Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance
    Laurence Huang
    University of California San Francisco, USA
    Emerg Infect Dis 10:1721-8. 2004
    ..Sulfa drugs, trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone are mainstays of PCP treatment and prophylaxis...
  25. ncbi Microcosm evaluation of the effects of an eight pharmaceutical mixture to the aquatic macrophytes Lemna gibba and Myriophyllum sibiricum
    Richard A Brain
    Department of Environmental Biology, Centre for Toxicology, University of Guelph, Guelph, Ont, N1G 2W1, Canada
    Aquat Toxicol 70:23-40. 2004
    ..12,000 L aquatic microcosms treated with eight common pharmaceuticals (atorvastatin, acetaminophen, caffeine, sulfamethoxazole, carbamazepine, levofloxacin, sertraline, and trimethoprim) at total (summed) molar concentrations of 0, 0...
  26. ncbi [Determination of sulfamethoxazole in compound sulfamethoxazole tablet by first derivative ratio spectrometry]
    Z Sun
    No. 1 Hospital of Lianyungang, Jiangsu, Lianyungang 222002
    Guang Pu Xue Yu Guang Pu Fen Xi 21:713-5. 2001
    The first derivative ratio spectrometry is used for the determination of sulfamethoxazole in compound sulfamethoxazole tablet...
  27. ncbi [Drug exanthema in connection with trimethoprim and sulfamethoxazole treatment, triggered by leech therapy]
    Andre Michael Beer
    Modellabteilung für Naturheilkunde, Klinik Blankenstein, Hattingen
    Forsch Komplementarmed Klass Naturheilkd 12:32-6. 2005
    ..Eight days before beginning of the leech therapy a five-day antibiotic therapy with trimethoprim and sulfamethoxazole (Cotrim forte) had been administered to treat an uncomplicated urinary infection...
  28. ncbi Urinary tract infections in South Croatia: aetiology and antimicrobial resistance
    Zvonimir Barisić
    Department of Microbiology, Public Health Institute, Vukovarska 46, 21000, Split, Croatia
    Int J Antimicrob Agents 22:61-4. 2003
    ..15% to the fluoroquinolones. A high methicillin-resistance rate was found among S. aureus (61.22%) and coagulase negative staphylococci (41.48)...
  29. ncbi Escherichia coli O157:H7 Shiga toxin-encoding bacteriophages: integrations, excisions, truncations, and evolutionary implications
    Nurmohammad Shaikh
    Children s Hospital and the University of Washington, Seattle, Washington, USA
    J Bacteriol 185:3596-605. 2003
    ..coli O157:H7 strains, the presumed progenitors of stx(1)(+)/stx(2)(+) E. coli O157:H7. Trimethoprim-sulfamethoxazole promotes the excision of all, and ciprofloxacin and fosfomycin significantly promote the excision of a subset ..
  30. ncbi Leptospira infection in two black rhinoceroses (Diceros bicornis michaeli)
    D L Neiffer
    Pittsburgh Zoo, One Wild Place, Pittsburgh, Pennsylvania 15206, USA
    J Zoo Wildl Med 32:476-86. 2001
    ..Leptospira kirschneri serovar grippotyphosa was postulated as the etiologic agent, with transmission probably occurring through wallow contamination by wild raccoons (Procyon lotor)...
  31. ncbi Comparative antimicrobial susceptibility of respiratory tract pathogens
    David Felmingham
    G R Micro Ltd, 7 9 William Road, London NW1 3ER, UK
    Chemotherapy 50:3-10. 2004
    ..Trimethoprim-sulfamethoxazole (TMP-SMX) and tetracycline resistance, either individually or combined with macrolide resistance as multiple ..
  32. ncbi Appropriate antibiotic utilization in seniors prior to hospitalization for community-acquired pneumonia is associated with decreased in-hospital mortality
    D Johnson
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Clin Pharm Ther 29:231-9. 2004
    ..We analysed the association of mortality and prescription of antibiotics prior to hospitalization for community-acquired pneumonia...
  33. ncbi Acute generalized exanthematous pustulosis due to sulfamethoxazol with positive lymphocyte transformation test (LTT)
    Mark David Anliker
    Allergy Unit, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    J Investig Allergol Clin Immunol 13:66-8. 2003
    ..LTT may play a possible role in the determination of drug allergy in AGEP despite negative skin testing...
  34. ncbi A case of brucellar septic arthritis of the knee with a prolonged clinical course
    Ergin Ayaslioglu
    Department of Infectious Diseases and Clinical Microbiology, Kirikkale University Faculty of Medicine, Kirikkale, Turkey
    Rheumatol Int 25:69-71. 2005
    ..We report a case of brucellar monoarthritis of the knee with a prolonged clinical course despite efficient antibiotic treatment...
  35. ncbi Teaching NeuroImage: Oculomasticatory myorhythmia: pathognomonic phenomenology of Whipple disease
    Fredy J Revilla
    Department of Neurology, Movement Disorders Center, University of Cincinnati, 231 Albert Sabin Way, MSB 4503, Cincinnati, OH 45267-0525, USA
    Neurology 70:e25. 2008
  36. ncbi Oropharyngeal colonization by Streptococcus pneumoniae among HIV-infected adults in Uganda: assessing prevalence and antimicrobial susceptibility
    David B Blossom
    Case Western Reserve University, Cleveland, Ohio, USA
    Int J Infect Dis 10:458-64. 2006
    ..To evaluate characteristics of Streptococcus pneumoniae associated with oropharyngeal colonization in the Ugandan adult HIV population...
  37. ncbi Micellar electrokinetic chromatography method for the determination of sulfamethoxazole, trimethoprim and their main metabolites in human serum
    Juan José Berzas Nevado
    Regional Institute for Applied Scientific Research, University of Castilla La Mancha, Avenida de Camilo José Cela, 10, 13071 Ciudad Real, Spain
    J Sep Sci 28:543-8. 2005
    ..sample clean-up and a micellar electrokinetic chromatographic method, is presented for the determination of sulfamethoxazole, trimethoprim, and their main metabolites by using 20 mmol L(-1) borate buffer (pH 9...
  38. ncbi An analysis of a community-acquired pathogen in a Kentucky community: methicillin-resistant Staphylococcus aureus
    Forest W Arnold
    University of Louisville School of Medicine, KY 40292, USA
    J Ky Med Assoc 103:206-10. 2005
    ..Reviewing risk factors in adult patients with CA-MRSA in Kentucky has not been reported...
  39. ncbi Prospective randomized trial of empiric therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus
    Mary Jo Cenizal
    University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Antimicrob Agents Chemother 51:2628-30. 2007
    To evaluate empirical therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus, a randomized, prospective, open-..
  40. ncbi Pulmonary nocardiosis: risk factors and outcomes
    Raquel Martínez Tomás
    Pneumology Service, Hospital Universitario La Fe, Valencia, and Universidad Autonoma de Barcelona, Barcelona, Spain
    Respirology 12:394-400. 2007
    ..which can behave either as opportunistic or primary pathogens. The present study identifies the risk factors for PN, clinical symptoms and radiographic features and the factors that affect its prognosis...
  41. ncbi Postpartum iliopsoas pyomyositis due to community-acquired methicillin-resistant Staphylococcus aureus
    Karen M Sokolov
    Department of Radiation Oncology, University of California Los Angeles, CA, USA
    Obstet Gynecol 110:535-8. 2007
    ..A new, serious community-acquired MRSA manifestation, postpartum iliopsoas pyomyositis is described...
  42. ncbi Multidrug-resistant Ewingella americana: a case report and review of the literature
    Melanie W Pound
    School of Pharmacy, Campbell University, Buies Creek, NC 27506, USA
    Ann Pharmacother 41:2066-70. 2007
    ..To describe and report a case of multidrug-resistant Ewingella americana associated with exacerbation of chronic obstructive pulmonary disease (COPD)...
  43. ncbi Intermittent unexplained abdominal pain: is it porphyria?
    Joseph R Bloomer
    Liver Center and Division of Gastroenterology Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    Clin Gastroenterol Hepatol 5:1255-8; quiz 1244. 2007
  44. ncbi Update on prevalence and treatment of methicillin-resistant Staphylococcus aureus infections
    Cindy A Loffler
    University of California, San Francisco Medical Center, 521 Parnassus Ave, C 152, San Francisco, CA 94122, USA
    Expert Rev Anti Infect Ther 5:961-81. 2007
    ..for treatment of MRSA infections, including older drugs, such as clindamycin, doxycycline and trimethoprim- sulfamethoxazole. Newer agents, such as linezolid and daptomycin, are aiming to improve on the poor cure rates found with ..
  45. ncbi A rare case of lung coinfection by Streptomyces cinereoruber and Haemophilus influenzae in a patient with severe chronic obstructive pulmonary disease: characterization at species level using molecular techniques
    Angel Manteca
    Area de Microbiologia, Departamento de Biologia Funcional, Instituto Universitario de Biotecnologia de Asturias IUBA, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain
    Diagn Microbiol Infect Dis 60:307-11. 2008
    ..Restriction fragment length polymorphism, morphologic, and biochemical characteristics have confirmed their identity...
  46. ncbi [Drug-induced cholestasis]
    Yasuyuki Searashi
    Division of Gastroenterology and Hepatology, Jikei University School of Medicine
    Nippon Rinsho 65:532-7. 2007
  47. ncbi Severe hypoglycemia associated with use of trimethoprim/sulfamethoxazole in a patient with chronic renal insufficiency
    Jamie M Rosini
    Ann Pharmacother 42:593-4. 2008
  48. ncbi Determination of six anti-infectives in wastewater using tandem solid-phase extraction and liquid chromatography-tandem mass spectrometry
    Pedro A Segura
    Departement de Chimie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, QC, CanadaH3C 3J7
    J Environ Monit 9:307-13. 2007
    ..Mean flows of anti-infectives were estimated from effluent concentrations and it was found that large amounts (>118 g day(-1) up to 830 g day(-1)) are discharged in the receiving waters of the St Lawrence River...
  49. ncbi Simultaneous determination and validation of antimicrobials in plasma and tissue of actinomycetoma by high-performance liquid chromatography with diode array and fluorescence detection
    Norma Cavazos Rocha
    Department of Analytical Chemistry, Facultad de Medicina, UANL, Mexico
    J Pharm Biomed Anal 43:1775-81. 2007
    ..antimicrobials proposed for the treatment of actinomycotic mycetoma: amoxicillin, trimethoprim, linezolid, sulfamethoxazole and garenoxacin. Separation of the analytes was achieved on an Atlantis dC18 column (150 mm x 4...
  50. ncbi Ecthyma gangrenosum in a patient with toxic epidermal necrolysis
    Douglas M Downey
    Department of Surgery, Wright State University School of Medicine, Dayton, Ohio, USA
    J Burn Care Res 28:198-202. 2007
    ..We present a case of a patient admitted to the burn unit for toxic epidermal necrolysis who developed pseudomonal bacteremia with ecthyma gangrenosum...
  51. ncbi Occurrence and sorption behavior of sulfonamides, macrolides, and trimethoprim in activated sludge treatment
    Anke Göbel
    Swiss Federal Institute for Environmental Science and Technology EAWAG, CH 8600 Dubendorf, Switzerland
    Environ Sci Technol 39:3981-9. 2005
    ..The most predominant macrolide and sulfonamide antimicrobials were clarithromycin and sulfamethoxazole, respectively...
  52. ncbi Evaluating the biodegradability of sulfamethazine, sulfamethoxazole, sulfathiazole, and trimethoprim at different stages of sewage treatment
    Sandra Perez
    The State University of New York at Buffalo, Chemistry Department, 611 Natural Sciences Complex, Buffalo, New York 14260 3000, USA
    Environ Toxicol Chem 24:1361-7. 2005
    The aerobic biodegradability of four antimicrobials (sulfamethazine, sulfamethoxazole, sulfathiazole, and trimethoprim) was investigated in sewage collected at four treatment stages (primary treatment, activated sludge treatment, aerobic ..
  53. ncbi Conjunctival flora in patients with human immunodeficiency virus infection
    Yasuyuki Yamauchi
    Department of Ophthalmology, Tokyo Medical University Hospital, Shinjuku, Tokyo, Japan
    Ocul Immunol Inflamm 13:301-4. 2005
    ..Also, to assess the prophylactic effect of oral clarithromycin against Mycobacterium avium complex on the conjunctival flora of HIV-positive patients...
  54. ncbi High-performance liquid chromatography method for the simultaneous determination of sulfamethoxazole and trimethoprim in bovine milk using an on-line clean-up column
    A V Pereira
    , Universidade Estadual de Ponta Grossa, 84030-900, Ponta Grossa, PR, Brazil
    J Chromatogr B Analyt Technol Biomed Life Sci 826:139-46. 2005
    A bidimensional HPLC method for the simultaneous determination of sulfamethoxazole (SMX) and trimethoprim (TMP) in bovine milk has been developed and validated...
  55. ncbi Antibiotic resistance in bacteria from shrimp farming in mangrove areas
    Tuan Xuan Le
    Centre for Natural Resources and Environmental Studies, Vietnam National University Hanoi, Quoc Tu Giam St, Vietnam
    Sci Total Environ 349:95-105. 2005
    ..to investigate bacterial resistance to Norfloxacin (NFXC), Oxolinic Acid (OXLA), Trimethoprim (TMP) and Sulfamethoxazole (SMX), which were found in four shrimp farming locations in mangrove areas in Vietnam...
  56. ncbi Evaluating the vulnerability of surface waters to antibiotic contamination from varying wastewater treatment plant discharges
    Angela L Batt
    Department of Chemistry, The State University of New York at Buffalo, 608 Natural Sciences Complex, Buffalo, NY 14260 3000, USA
    Environ Pollut 142:295-302. 2006
    ..b>Sulfamethoxazole, trimethoprim, ciprofloxacin, tetracycline, and clindamycin were detected in the effluents at concentrations ..
  57. ncbi Bartonella henselae bacilli detected in vitrectomy aspirates in a patient with massive vitreous opacity with total retinal detachment
    Toshihiko Matsuo
    Department of Ophthalmology, Okayama University Graduate School of Medicine and Dentistry, Okayama City, Japan
    Ocul Immunol Inflamm 14:47-9. 2006
    ..To present endophthalmitis-like massive vitreous opacity as a manifestation of cat-scratch disease...
  58. ncbi [Inguinal swelling: pressure-sensitive, overheated. A 66-year-old patient, pensioner in Portugal]
    V Orelli
    Medizinische Abteilung, Bezirksspital, Affoltern am Albis
    Praxis (Bern 1994) 95:1845-7. 2006
  59. ncbi N. paucivorans infection presenting as a brain abscess
    Shah-Naz Hayat Khan
    Division of Neurosurgery, Department of Surgery Saskatoon, SK, Canada
    Can J Neurol Sci 33:426-7. 2006
  60. ncbi Hepatic disposition of trimethoprim and sulfamethoxazole
    S Sahin
    Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
    Methods Find Exp Clin Pharmacol 30:135-40. 2008
    Hepatic disposition of trimethoprim (TMP) and sulfamethoxazole (SMX) and the liver distributional volumes were investigated in the in situ perfused rat liver preparation...
  61. ncbi Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis
    Javier Fernandez
    Liver Unit, IMD, and Department of Microbiology and IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Hepatology 35:140-8. 2002
    ..01. The rate of culture-positive spontaneous bacterial peritonitis caused by trimethoprim-sulfamethoxazole-resistant gram-negative bacilli was also very high in patients on long-term norfloxacin administration (44% ..
  62. ncbi Septicaemic pasteurellosis in ostriches (Struthio camelus) in central Saudi Arabia
    M G Elfaki
    Department of Veterinary Medicine, King Saud University, Gassim Branch, Buraidah, Saudi Arabia
    Vet J 163:218-21. 2002
  63. ncbi Pneumocystis carinii infection in bilateral aural polyps in a human immunodeficiency virus-positive patient
    C V Praveen
    Department of Otolaryngology, Farnborough Hospital, Bromley NHS Trust, Kent, UK
    J Laryngol Otol 116:288-90. 2002
    ..We report a case of P carinii infection presenting as bilateral aural polyps, otitis media and mastoiditis in human immunodeficiency (HIV)-positive patient with no history of prior or concomitant P carinii infection...
  64. ncbi [A case of empyema caused by Salmonella enteritidis in a patient with sequela of pulmonary tuberculosis]
    H Suzuki
    Department of Pulmonary Diseases, Tokyo Metropolitan Komagome General Hospital, Japan
    Kansenshogaku Zasshi 70:382-5. 1996
    ..Based on the in vitro sensitivity test, sulfamethoxazole/trimethoprim was started. However, the efficacy of the antimicrobia was not sufficient...
  65. ncbi Evaluation of the effect of sulphametoxazole and trimethoprim in patients with Machado-Joseph disease
    M Correia
    Neurology Department, , Porto, Portugal
    Rev Neurol 23:632-4. 1995
    ..The results showed that Bactrim had a beneficial effect on gait and coordination and that it would be worthwhile undertaking other trials, taking into account the great clinical variability of MJD...
  66. ncbi Second derivative spectrophotometric determination of trimethoprime and sulfamethoxazole in the presence of hydroxypropyl-beta-cyclodextrin (HP-beta-CD)
    Gladys Granero
    Departamento de Farmacia, , , Ciudad Universitaria, , Argentina
    J Pharm Biomed Anal 29:51-9. 2002
    ..rapid second-derivative spectrophotometric method for the simultaneous analysis of trimethoprime (TMP) and sulfamethoxazole (SM) is described...
  67. ncbi Antibiotic resistance among Shigella species isolated in Tehran, Iran
    J Nikkah
    Department of Infectious Diseases, Buali Hospital, Tehran, Iran
    Ann Trop Med Parasitol 82:481-3. 1988
    ..Resistance to nalidixic acid was not encountered. In view of the fact that this disorder tends to be a self-limiting condition in Iran, it is advisable to be selective and cautious in the use of antibiotics for treatment...
  68. ncbi Clinical and pathologic features of Mycobacterium fortuitum infections. An emerging pathogen in patients with AIDS
    M B Smith
    Division of Microbiology, Dept of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-074, USA
    Am J Clin Pathol 116:225-32. 2001
    ..Definitive therapy after culture identification resulted in complete resolution of infection in all patients except 1...
  69. ncbi [A case of pulmonary nocardiosis associated with middle lobe atelectasis]
    S Kuroki
    Saga Medical School
    Kansenshogaku Zasshi 64:243-8. 1990
    ..Nocardia asteroides was isolated from her sputum and bronchial lavage fluid. Administration of sulfamethoxazole-trimethoprim (ST) improved her symptoms and Nocardia asteroides were rapidly eliminated from her sputum...
  70. ncbi Antimicrobial susceptibility of Haemophilus influenzae among children in Beijing, China, 1999-2000
    Y Y Hu
    Department of Microbiology and Immunology, Beijing Children s Hospital, P R China
    Acta Paediatr 91:136-40. 2002
    ..Sulphamethoxazole/ trimethoprim resistance rates increased rapidly compared with those in the 1999 data. Further surveillance investigations are important for the choice of empiric therapy of acute respiratory tract infection...
  71. ncbi The importance of the removal of the intrauterine device in genital colonization by actinomyces
    I Bonacho
    , ,
    Gynecol Obstet Invest 52:119-23. 2001
    ..Both groups were treated with trimethoprim and sulfamethoxazole. A total of 43 patients were included...
  72. ncbi Nasopharyngeal carriage of community-acquired, antibiotic-resistant Streptococcus pneumoniae in a Zambian paediatric population
    A Woolfson
    Department of Medicine, John Radcliffe Hospital, University of Oxford, England
    Bull World Health Organ 75:453-62. 1997
    ..Antibacterial resistance was found in 34.1% of the isolates; resistance to tetracycline, penicillin, sulfamethoxazole + trimethoprim, and chloramphenicol occurred in 23.0%, 14.3%, 12.7%, and 3.9% of the isolates, respectively...
  73. ncbi Simultaneous dissolution profiles of two drugs in pharmaceutical formulations by an FIA manifold
    A Moreno Gálvez
    Departamento de Quimica Analitica, Facultad de Ciencias Quimicas, Universidad de Valencia, c Moliner 50, 46100 Burjassot, Valencia, Spain
    J Pharm Biomed Anal 27:1027-36. 2002
    ..The analytical errors, when the concentration of one drug is very low or very high, are also checked. A binary mixture in commercially available formulations of solid oral administration of sulphametoxazole and trimethoprim is presented...
  74. ncbi Viable but nonculturable uropathogenic bacteria are present in the mouse urinary tract following urinary tract infection and antibiotic therapy
    B Rivers
    Department of Biology, University of North Carolina at Charlotte, 9201 University City Blvd, Charlotte, NC 282230001, USA
    Urol Res 29:60-6. 2001
    ..These data indicate that the inoculated uropathogenic E. coli was not eliminated by antibiotic therapy, and suggest that these bacteria may escape detection by current standard culturability assays because they are VBNC...
  75. ncbi Antibiotic resistance from wastewater oxidation ponds
    Heather Mispagel
    University of Georgia College of Veterinary Medicine, Athens, USA
    Water Environ Res 77:2996-3002. 2005
    ..A public awareness campaign was initiated by the author to encourage proper use and disposal of antibiotics, as flushing them is a common practice in the United States...
  76. ncbi Toxic epidermal necrolysis following combination of methotrexate and trimethoprim-sulfamethoxazole
    C H Yang
    Department of Dermatology, and Department of Pediatrics, Division of Hematology and Oncology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Int J Dermatol 39:621-3. 2000
    ..In addition, oral trimethoprim-sulfamethoxazole was given regularly to prevent Pneumocystis carinii infection...
  77. ncbi Molecular characterization of multidrug-resistant Salmonella enterica subsp. enterica serovar Typhimurium isolates from swine
    Wondwossen Abebe Gebreyes
    Department of Farm Animal Health Resources Management, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    J Clin Microbiol 40:2813-22. 2002
    ..The first was resistance to ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline (the AmCmStSuTe phenotype; 36...
  78. ncbi Otitis media-related antibiotic prescribing patterns, outcomes, and expenditures in a pediatric medicaid population
    S Berman
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Pediatrics 100:585-92. 1997
    ..However, only limited data are available on medical effectiveness of antibiotic prescribing patterns for otitis media and their associated expenditures or the factors that influence antibiotic prescribing...
  79. ncbi Laboratory detection methods for methicillin resistance in coagulase negative Staphylococcus isolated from ophthalmic infections
    Adália Dias Dourado Oliveira
    Departamento de Oftalmologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Arq Bras Oftalmol 70:667-75. 2007
    ....
  80. ncbi Multidrug-resistant Salmonella enterica serovar Muenchen from pigs and humans and potential interserovar transfer of antimicrobial resistance
    Wondwossen A Gebreyes
    Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St, Raleigh, NC 27606, USA
    Antimicrob Agents Chemother 49:503-11. 2005
    ..enterica serovar Typhimurium strains among pigs with resistance to ampicillin, kanamycin, streptomycin, sulfamethoxazole, and tetracycline (resistance [R] type AKSSuT) and resistance to amoxicillin-clavulanic acid, ampicillin, ..
  81. ncbi New enterovirulent Escherichia coli serogroup 64474 showing antigenic and genotypic relationships to Shigella boydii 16
    Armando Navarro
    Departamento de Salud Publica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico City DF 04510, Mexico
    J Med Microbiol 59:453-61. 2010
    ..coli strains showed antimicrobial resistance to piperacillin only, one (4 %) to piperacillin and trimethoprim/sulfamethoxazole, one (4 %) to ciprofloxacin, nitrofurantoin and piperacillin, and two (9 %) strains were resistant to ..
  82. ncbi Susceptibilities to levofloxacin in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis clinical isolates from children: results from 2000-2001 and 2001-2002 TRUST studies in the United States
    James A Karlowsky
    Focus Technologies, Herndon, Virginia 20171, USA
    Antimicrob Agents Chemother 47:1790-7. 2003
    ..pneumoniae from children, resistance to penicillins, cephalosporins, macrolides, and trimethoprim-sulfamethoxazole (SXT) increases on an annual basis...
  83. ncbi Characterization of methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci and extended-spectrum beta-lactamase-producing Escherichia coli in intensive care units in Canada: Results of the Canadian National Intensive Care Unit (CAN-
    George G Zhanel
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba
    Can J Infect Dis Med Microbiol 19:243-9. 2008
    ..Methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and vancomycin-resistant enterococci (VRE) are important hospital pathogens in Canada and worldwide...
  84. ncbi High rates of multiple antibiotic resistance in Streptococcus pneumoniae from healthy children living in isolated rural communities: association with cephalosporin use and intrafamilial transmission
    M H Samore
    Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
    Pediatrics 108:856-65. 2001
    ....
  85. ncbi High incidence of antimicrobial resistant organisms including extended spectrum beta-lactamase producing Enterobacteriaceae and methicillin-resistant Staphylococcus aureus in nasopharyngeal and blood isolates of HIV-infected children from Cape Town, South
    Mark F Cotton
    Department of Paediatrics, Faculty of Health Sciences, Stellenbosch University, Cape Town South Africa
    BMC Infect Dis 8:40. 2008
    ..aim was to describe the organisms and antimicrobial resistance patterns in children enrolled in a prospective study comparing daily and three times weekly trimethoprim-sulfamethoxazole (TMP-SMX) and isoniazid (INH) or placebo prophylaxis.
  86. ncbi Susceptibilities of Haemophilus influenzae, Streptococcus pneumoniae, including serotype 19A, and Moraxella catarrhalis paediatric isolates from 2005 to 2007 to commonly used antibiotics
    Christopher J Harrison
    Pediatric Infectious Diseases Section, Children s Mercy Hospital and Clinics, and the University of Missouri Kansas City, Kansas City, MO, USA
    J Antimicrob Chemother 63:511-9. 2009
    ..The aim of this study was to evaluate susceptibility to common paediatric antibiotics for Streptococcus pneumoniae, non-typeable Haemophilus influenzae and Moraxella catarrhalis isolated from 2005 through 2007...
  87. ncbi Clinical efficacy of first- and second-line treatments for HIV-associated Pneumocystis jirovecii pneumonia: a tri-centre cohort study
    Jannik Helweg-Larsen
    Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
    J Antimicrob Chemother 64:1282-90. 2009
    First-line therapy for Pneumocystis jirovecii pneumonia (PCP) is trimethoprim/sulfamethoxazole. Few data exist to guide the choice of second-line therapy for patients failing or developing toxicity to first-line therapy.
  88. ncbi Memantine-induced myoclonus and delirium exacerbated by trimethoprim
    Dan Moellentin
    Eastern Maine Medical Center, Inpatient Pharmacy, 489 State St, PO Box 404, Bangor, ME 04401, USA
    Ann Pharmacother 42:443-7. 2008
    ..To report a case of myoclonus and delirium seen in a patient taking a combination of memantine and trimethoprim...
  89. ncbi Epidemiology and antibiotic susceptibility of bacteria causing skin and soft tissue infections in the USA and Europe: a guide to appropriate antimicrobial therapy
    Mark E Jones
    Focus Technologies, Dwarsdijk 30, 3612AP Tienhoven, Netherlands
    Int J Antimicrob Agents 22:406-19. 2003
    ..For P. aeruginosa piperacillin-tazobactam, amikacin, imipenem and ceftazidime were the most active compounds tested irrespective of region. Surveillance data should be considered when selecting empirical therapy for treating SSTI...
  90. ncbi Successful prophylaxis against Pneumocystis carinii pneumonia in HIV-infected children using smaller than recommended dosages of trimethoprim-sulfamethoxazole
    R G Fisher
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk, USA
    AIDS Patient Care STDS 15:263-9. 2001
    ..No dose-ranging studies were ever performed; therefore, the amount of trimethoprim-sulfamethoxazole (TMP-SMX) needed to suppress PCP in children with HIV/AIDS is not known...
  91. ncbi Comparison of antimicrobial in vitro activities against Streptococcus pneumoniae independent of MIC susceptibility breakpoints using MIC frequency distribution curves, scattergrams and linear regression analyses
    R J Fass
    Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
    J Antimicrob Chemother 48:609-15. 2001
    ..MICs of penicillin G, ampicillin/sulbactam, ceftriaxone, cefuroxime, erythromycin, tetracycline, trimethoprim/sulfamethoxazole, ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin were determined for 646 strains...
  92. ncbi Isolation, molecular characterization and antimicrobial resistance patterns of Salmonella and Escherichia coli isolates from meat-based fast food in Lebanon
    Steve Harakeh
    Department of Biology, American University of Beirut, PO Box 11 0236, Beirut, Lebanon
    Sci Total Environ 341:33-44. 2005
    ..the various strains were evaluated using the following antimicrobials: Oxacillin, Teicoplanin, Trimethoprim/sulfamethoxazole, Gentamicin, Clindamycin, Cefotaxime, Cefuroxime, Erythromycin, and Vancomycin...
  93. ncbi [The rate of inducible clindamycin resistance and susceptibilities to other antimicrobial agents in staphylococci]
    Vildan Avkan Oğuz
    Dokuz Eylul Universitesi Tip Fakultesi, Enfeksiyon Hastaliklari ve Klinik Mikrobiyoloji Anabilim Dali, Izmir
    Mikrobiyol Bul 43:37-44. 2009
    ..Inducible clindamycin resistance must be anticipated carefully while considering therapeutic options especially for CoNS infections...
  94. ncbi Prospective randomized trial of trimethoprim/sulfamethoxazole versus pyrimethamine and sulfadiazine in the treatment of ocular toxoplasmosis
    Masoud Soheilian
    Ocular Inflammatory and Uveitis Service, Department of Ophthalmology, and Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Ophthalmology 112:1876-82. 2005
    To compare the efficacy of the classic treatment of ocular toxoplasmosis (pyrimethamine, sulfadiazine, and prednisolone) with a regimen consisting of trimethoprim/sulfamethoxazole (co-trimoxazole) plus prednisolone.
  95. ncbi Susceptibility of Bacillus anthracis, Bacillus cereus, Bacillus mycoides, Bacillus pseudomycoides and Bacillus thuringiensis to 24 antimicrobials using Sensititre automated microbroth dilution and Etest agar gradient diffusion methods
    Vicki A Luna
    Center for Biological Defense, College of Public Health, University of South Florida, 3602 Spectrum Boulevard, Tampa, FL 33612, USA
    J Antimicrob Chemother 60:555-67. 2007
    ..To examine susceptibilities of Bacillus anthracis and related species to 24 antimicrobials using and concurrently comparing two methods...
  96. ncbi Pharmacokinetics of dapsone gel, 5% for the treatment of acne vulgaris
    Diane M Thiboutot
    Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA
    Clin Pharmacokinet 46:697-712. 2007
    ..As dapsone is administered topically, it was expected that systemic absorption would be considerably lower than that observed with oral dapsone therapy, thereby avoiding any adverse haematological effects...
  97. ncbi Multisite reproducibility of Etest for susceptibility testing of Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium fortuitum
    G L Woods
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 0740, USA
    J Clin Microbiol 38:656-61. 2000
    ..tested against amikacin, cefoxitin, ciprofloxacin, clarithromycin, doxycycline, imipenem, and trimethoprim-sulfamethoxazole in each of four laboratories...
  98. ncbi Comparison of atovaquone and azithromycin with trimethoprim-sulfamethoxazole for the prevention of serious bacterial infections in children with HIV infection
    Walter T Hughes
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Clin Infect Dis 40:136-45. 2005
    Trimethoprim-sulfamethoxazole (TMP-SMZ) has been used extensively for the prevention of Pneumocystis carinii (also referred to as "Pneumocystis jiroveci") pneumonia (PCP) and other opportunistic infections in human ..
  99. ncbi [Antibiotic consumption and antimicrobial susceptibility evolution in the Centro Hospitalario Pereira Rossell in methicillin resistant Staphylococcus aureus era]
    Héctor Telechea
    Depto de Farmacología y Terapéutica Montevideo, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    Rev Chilena Infectol 26:413-9. 2009
    ..Adherence to these guidelines was indirectly performed by monitoring antibiotic consumption and antimicrobial susceptibility patterns in Uruguay...
  100. ncbi In vitro antibacterial activity of beta-lactams and non-beta-lactams against Streptococcus pneumoniae isolates from Sydney, Australia
    Iain B Gosbell
    Department of Microbiology, South Western Area Pathology Service, Liverpool, Australia
    Pathology 38:343-8. 2006
    ..This study was undertaken to determine the antimicrobial resistance patterns of strains of Streptococcus pneumoniae from Sydney, Australia, comparing penicillin-susceptible, -intermediate and -resistant isolates...
  101. ncbi Susceptibility of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis to 17 oral antimicrobial agents based on pharmacodynamic parameters: 1998-2001 U S Surveillance Study
    Michael R Jacobs
    Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Clin Lab Med 24:503-30. 2004
    ..8% to cefprozil and cefdinir, 72.6% to cefuroxime axetil, 66.3% to cexime, 63.7% to trimethoprim/sulfamethoxazole, and 19.7% to cefaclor. Among H influenzae isolates, 28...

Research Grants73

  1. Cranberry: Interactions with Anti-infectious Agents
    Gail Anderson; Fiscal Year: 2005
    ..The bacterial pathogens in UTI are typically responsive to trimethoprim-sulfamethoxazole, quinolones, and the beta-lactams (penicillins, cephalosporins)...
  2. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2003
    DESCRIPTION: Two recent studies found that trimethoprim-sulfamethoxazole (TS) prophylaxis reduced hospitalizations and mortality among HIV-infected persons in Cote d'Ivoire, and policies of widespread TS prophylaxis for HIV-infected ..
  3. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2007
    ..Trimethoprim/sulfamethoxazole the combination of a dihydrofolate reductase (DHFR) inhibitor trimethoprim and a dihydropteroate synthase (..
  4. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2009
    ..Trimethoprim/sulfamethoxazole the combination of a dihydrofolate reductase (DHFR) inhibitor trimethoprim and a dihydropteroate synthase (..
  5. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Goals: Assess poultry contact and consumption as risk factors for human colonization with trimethoprim-sulfamethoxazole (TS)-, fluoroquinolone (FQ)-, and extended-spectrum cephalosporin (ESC)-resistant E. coli (i.e...
  6. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2007
    Studies in Cote D'lvoire found that trimethoprim-sulfamethoxazole (TS) reduced hospitalizations and mortality among HIV-infected persons who were not receiving antiretroviral therapy...
  7. Epidemic CA-MRSA: Molecular Epidemiology and Immunology
    ROBERT S contact DAUM; Fiscal Year: 2010
    ..the patients enrolled in the DMID-funded "Randomized, Double-Blind Trial of Clindamycin, Trimethoprim-Sulfamethoxazole, or Placebo for Uncomplicated Skin and Soft Tissue Infections Caused by Community-Associated Methicillin-..
  8. Structural Studies of AIDS-Responsive Drugs
    Vivian Cody; Fiscal Year: 2007
    ..Current treatment for PcP combines sulfamethoxazole with trimethoprim, targeting folate biosynthesis...
  9. Structural Studies of AIDS-Responsive Drugs
    Vivian Cody; Fiscal Year: 2010
    ..Current treatment for PcP combines sulfamethoxazole with trimethoprim, targeting folate biosynthesis...
  10. S-Adenosylmethionine and Pneumocystis treatment
    Salim Merali; Fiscal Year: 2007
    ..the ability of nicotine to treat rat model of PCP: We will look for synergism using nicotine and trimethoprim/sulfamethoxazole, the primary drug for treatment of PCP...
  11. S-Adenosylmethionine and Pneumocystis treatment
    Salim Merali; Fiscal Year: 2009
    ..the ability of nicotine to treat rat model of PCP: We will look for synergism using nicotine and trimethoprim/sulfamethoxazole, the primary drug for treatment of PCP...
  12. Mechanisms of Cutaneous Drug Reactions
    CRAIG SVENSSON; Fiscal Year: 2004
    ..The objective of the present proposal is to test the validity of our hypothesis using sulfamethoxazole (SMX) and dapsone, which are among the most frequent CDR-inducing drugs, as model compounds...
  13. PNEUMOCYSTIS CARINII IN CONTINOUS AXENIC CULTURE
    ALLEN CLARKSON JR; Fiscal Year: 2001
    ..These isolates will be studied in vitro for sensitivity to the combination of trimethoprim + sulfamethoxazole (the mainstay for both treatment of and prophylaxis against P...