flutamide

Summary

Summary: An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Top Publications

  1. pmc Effects of long-term flutamide treatment during development in zebra finches
    William Grisham
    Department of Psychology and Laboratory of Neuroendocrinology of Brain Research Institute, University of California, Los Angeles, CA 90095 1563, United States
    Neurosci Lett 418:92-6. 2007
  2. doi Lyophilization monophase solution technique for improvement of the physicochemical properties of an anticancer drug, flutamide
    Nazik Elgindy
    Department of Industrial Pharmacy, University of Alexandria, Alexandria, Egypt
    Eur J Pharm Biopharm 74:397-405. 2010
  3. pmc Prenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophy
    Jamie A Johansen
    Neuroscience Program, Michigan State University, East Lansing, MI 48109, USA
    Neurodegener Dis 8:25-34. 2011
  4. ncbi Effects of 17beta-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhage
    Frank Hildebrand
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, G094 Volker Hall, 1670 University Boulevard, Birmingham, AL 35294 0019, USA
    Cytokine 36:107-14. 2006
  5. ncbi Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trial
    J Calaf
    Servicio de Obstetricia y Ginecologia, Hospital de la Santa Creu i Sant Pau, Avenida Sant Antoni M Claret, 167, 08025 Barcelona, Spain
    J Clin Endocrinol Metab 92:3446-52. 2007
  6. ncbi Combined low-dose pioglitazone, flutamide, and metformin for women with androgen excess
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 92:1710-4. 2007
  7. ncbi Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate
    Eve Mylchreest
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Reprod Toxicol 16:19-28. 2002
  8. doi Short-term neoadjuvant androgen deprivation therapy and external-beam radiotherapy for locally advanced prostate cancer: long-term results of RTOG 8610
    Mack Roach
    Department of Radiation Oncology, University of California San Francisco, 1600 Divisadero St, Suite H1031, San Francisco, CA 94143 1708, USA
    J Clin Oncol 26:585-91. 2008
  9. ncbi Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females
    Frank Hildebrand
    Department of Surgery, University of Alabama at Birmingham, AL 35294 0019, USA
    J Leukoc Biol 80:759-65. 2006
  10. ncbi Flutamide depresses expression of cortactin in the ectoplasmic specialization between the Sertoli cells and spermatids in the mouse testis
    Reiko Anahara
    Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoku, Chiba 260 8670, Japan
    Food Chem Toxicol 44:1050-6. 2006

Research Grants

  1. Testosterone stimulation of insulin signalingin adipocytes
    Wayne E Taylor; Fiscal Year: 2010
  2. Testosterone stimulation of insulin signalingin adipocytes
    Wayne Taylor; Fiscal Year: 2009
  3. Hormonal Mechanisms of Postmenopausal Hypertension
    JANE RECKELHOFF; Fiscal Year: 2005
  4. Hormonal Mechanisms of Postmenopausal Hypertension
    JANE RECKELHOFF; Fiscal Year: 2004
  5. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2001
  6. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2000
  7. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2002
  8. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2002
  9. Maintainance of Organ Function Following Injury
    Irshad Chaudry; Fiscal Year: 2006
  10. Developmental programming: influence of sex steroids and mechanisms
    Chandrasekhar Yallampalli; Fiscal Year: 2011

Detail Information

Publications209 found, 100 shown here

  1. pmc Effects of long-term flutamide treatment during development in zebra finches
    William Grisham
    Department of Psychology and Laboratory of Neuroendocrinology of Brain Research Institute, University of California, Los Angeles, CA 90095 1563, United States
    Neurosci Lett 418:92-6. 2007
    ..Co-administering flutamide, an androgen receptor blocker, with estrogen impedes estrogen's masculinizing effects on the song system, ..
  2. doi Lyophilization monophase solution technique for improvement of the physicochemical properties of an anticancer drug, flutamide
    Nazik Elgindy
    Department of Industrial Pharmacy, University of Alexandria, Alexandria, Egypt
    Eur J Pharm Biopharm 74:397-405. 2010
    b>Flutamide (FLT), an anticancer drug for prostatic carcinoma, has poor aqueous solubility and low oral bioavailability...
  3. pmc Prenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophy
    Jamie A Johansen
    Neuroscience Program, Michigan State University, East Lansing, MI 48109, USA
    Neurodegener Dis 8:25-34. 2011
    ..We have previously reported that AR toxicity was ligand dependent in our model, and that very few transgenic (tg) males survived beyond birth...
  4. ncbi Effects of 17beta-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhage
    Frank Hildebrand
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, G094 Volker Hall, 1670 University Boulevard, Birmingham, AL 35294 0019, USA
    Cytokine 36:107-14. 2006
    ..females following trauma-hemorrhage, we hypothesized that administration of the androgen receptor antagonist flutamide at the onset of resuscitation will maintain the immune function of the spleen following trauma-hemorrhage...
  5. ncbi Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trial
    J Calaf
    Servicio de Obstetricia y Ginecologia, Hospital de la Santa Creu i Sant Pau, Avenida Sant Antoni M Claret, 167, 08025 Barcelona, Spain
    J Clin Endocrinol Metab 92:3446-52. 2007
    Our objective was to test the efficacy and tolerability of three doses of flutamide (125, 250, and 375 mg) combined with a triphasic oral contraceptive (ethynylestradiol/levonorgestrel) during 12 months to treat moderate to severe ..
  6. ncbi Combined low-dose pioglitazone, flutamide, and metformin for women with androgen excess
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 92:1710-4. 2007
    ..treatments for hyperinsulinemic hyperandrogenism in nonobese women is combined androgen receptor blockade (with flutamide; Flu), insulin sensitization (with metformin; Met) plus an estroprogestagen contraceptive...
  7. ncbi Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate
    Eve Mylchreest
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Reprod Toxicol 16:19-28. 2002
    ..Although similar effects are produced by the potent androgen receptor (AR) antagonist flutamide and are indicative of disruption of male sexual differentiation via an antiandrogenic mechanism, DBP is not an ..
  8. doi Short-term neoadjuvant androgen deprivation therapy and external-beam radiotherapy for locally advanced prostate cancer: long-term results of RTOG 8610
    Mack Roach
    Department of Radiation Oncology, University of California San Francisco, 1600 Divisadero St, Suite H1031, San Francisco, CA 94143 1708, USA
    J Clin Oncol 26:585-91. 2008
    ..This report summarizes long-term follow-up results...
  9. ncbi Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females
    Frank Hildebrand
    Department of Surgery, University of Alabama at Birmingham, AL 35294 0019, USA
    J Leukoc Biol 80:759-65. 2006
    We hypothesized that administration of androgen receptors antagonist flutamide following trauma-hemorrhage (T-H) in metestrus females will maintain immune function and reduce remote organ damage under those conditions...
  10. ncbi Flutamide depresses expression of cortactin in the ectoplasmic specialization between the Sertoli cells and spermatids in the mouse testis
    Reiko Anahara
    Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoku, Chiba 260 8670, Japan
    Food Chem Toxicol 44:1050-6. 2006
    b>Flutamide (FLUT) has potent anti-androgenic activity and is used in the medical field and in a screening test to detect endocrinologically active compounds...
  11. ncbi Quality-adjusted survival (Q-TWiST) analysis of EORTC trial 30853: comparing goserelin acetate and flutamide with bilateral orchiectomy in patients with metastatic prostate cancer. European Organization for Research and Treatment of Cancer
    I Rosendahl
    Data Center, European Organization for Research and Treatment of Cancer, Brussels, Belgium
    Prostate 38:100-9. 1999
    ..However, the MAB treatment arm had a higher frequency of reported side effects...
  12. ncbi Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
    Renato Simões Cordeiro
    Department of Cell Biology, Institute of Biology, UNICAMP, CP 6109, 13084 971, Campinas, SP, Brazil
    Biocell 28:21-30. 2004
    The flutamide antiandrogenic effects on the Guinea pig male prostate morphology in puberal, post-puberal and adult ages were evaluated in the present study...
  13. ncbi Play, copulation, anatomy, and testosterone in gonadally intact male rats prenatally exposed to flutamide
    Joseph M Casto
    Department of Psychology, Villanova University, Villanova, PA 19085, USA
    Physiol Behav 79:633-41. 2003
    ..copulatory patterns was evaluated in male offspring of rats injected with 5 mg of the androgen receptor blocker flutamide (4'-nitro-3'-trifluoromethylisobutyranilide) from Days 11-21 of pregnancy...
  14. doi Suppression of mutant androgen receptors by flutamide
    Junichiro Ishioka
    Department of Urology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Urol 16:516-21. 2009
    To examine the effects of flutamide and hydroxyflutamide on the transactivation of mutant androgen receptors.
  15. ncbi Optimization of formulation parameters for the preparation of flutamide liposomes by 3(3) factorial 26-term logit model
    R S R Murthy
    Pharmacy Department, Faculty of Technology and Engineering, MS University of Baroda, Gujarat, India
    Pharm Dev Technol 9:369-77. 2004
    ..PC): cholesterol (Chol) molar ratio (X3) using 3(3) factorial 26-term logit model to maximize the Flutamide absorption at the target site in the treatment of prostatic cancer by maximizing the entrapment of Flutamide (..
  16. doi Mate calling behavior of male South African clawed frogs (Xenopus laevis) is suppressed by the antiandrogenic endocrine disrupting compound flutamide
    Thomas Behrends
    Institute of Biology, Humboldt University Berlin, Berlin, Germany
    Gen Comp Endocrinol 168:269-74. 2010
    ..Several environmental pollutants have been identified as antiandrogenic endocrine disrupting chemicals (EDC), with flutamide (FLU) being a model compound for this type of action...
  17. doi Lyophilized flutamide dispersions with polyols and amino acids: preparation and in vitro evaluation
    Nazik Elgindy
    Department of Industrial Pharmacy, Faculty of Pharmacy, University of Alexandria, 1 El Khartoum Square, El Azarita, Alexandria, Egypt
    Drug Dev Ind Pharm 37:446-55. 2011
    b>Flutamide (FLT) has poor aqueous solubility and low oral bioavailability.
  18. doi Are expression and localization of tight and adherens junction proteins in testes of adult boar affected by foetal and neonatal exposure to flutamide?
    A Hejmej
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Int J Androl 35:340-52. 2012
    Several recent studies have indicated that androgen disruption induced by the administration of anti-androgen flutamide during critical developmental stages results in various reproductive abnormalities, mainly in rodents...
  19. doi Biopolymeric microparticles combined with lyophilized monophase dispersions for controlled flutamide release
    Nazik Elgindy
    Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, El Khartoum Square, Azarita, Alexandria 21521, Egypt
    Int J Pharm 411:113-20. 2011
    Despite its short half-life, no controlled release formula of flutamide (FLT) was prepared until now...
  20. doi Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species
    Jessica Amadio
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, University College Dublin, Ardmore House, Dublin 4, Ireland
    Biotechnol Lett 33:321-6. 2011
    ..We report the transformation of the anti-cancer drug flutamide in Cunninghamella sp...
  21. ncbi An environmental antiandrogen, vinclozolin, alters the organization of play behavior
    A K Hotchkiss
    Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA
    Physiol Behav 79:151-6. 2003
    ..neonatal male rats were injected from Postnatal Days (PND) 2 to 3 with corn oil, pharmacological antiandrogen flutamide (50 mg/kg/day) or vinclozolin (200 mg/kg/day); whereas neonatal females were treated either with corn oil or ..
  22. ncbi Flutamide inhibits nifedipine- and interleukin-1 beta-induced collagen overproduction in gingival fibroblasts
    H K Lu
    Periodontal Department, Taipei Medical University College of Oral Medicine, Taipei, Taiwan
    J Periodontal Res 45:451-7. 2010
    To understand the role of the androgen receptor in gingival overgrowth, the effects of flutamide on interleukin-1 beta- and nifedipine-induced gene expression of connective tissue growth factor (CTGF/CCN2) and collagen production in ..
  23. ncbi Effects of the antiandrogen flutamide on the expression of protein kinase C isoenzymes in LNCaP and PC3 human prostate cancer cells
    Leire Montalvo
    Departamento de Bioquimica y Biologia Molecular, Universidad de Alcala, E 28871 Alcala de Henares, Spain
    Biosci Rep 24:11-21. 2004
    b>Flutamide is a nonsteroidal antiandrogen that is frequently used for total androgen blockage in the treatment of advanced prostate cancer...
  24. ncbi Clinical efficacy of low dose flutamide plus Diane-35 in the treatment of idiopathic hirsutism and polycystic ovary syndrome
    Abdullah Boztosun
    Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey
    Ginekol Pol 84:258-62. 2013
    ..The aim of this study was to evaluate the efficacy of flutamide plus diane 35 in the treatment of idiopathic hirsutism and polycystic ovary syndrome.
  25. ncbi Novel reagents for the sensitive spectrophotometric determination of flutamide, an anticancer drug in pharmaceutical preparations
    Padmarajaiah Nagaraja
    Department of Studies in Chemistry, University of Mysore, Manasagangotri, 570 006, Mysore, India
    Int J Pharm 235:113-20. 2002
    Simple and sensitive spectrophotometric methods for the determination of flutamide (FLA) in either pure form or in its pharmaceutical preparations are described...
  26. ncbi The mitochondrial-dependent pathway is chronically affected in testicular germ cell death in adult rats exposed in utero to anti-androgens
    A Bozec
    Institut National de la Santé et de la Recherche Médicale INSERM U 407, Faculté de médecine Lyon Sud, BP 12, 69921 Oullins, France
    J Endocrinol 183:79-90. 2004
    ..By using rats exposed in utero to the anti-androgenic compound flutamide (0...
  27. doi Adjuvant therapy with flutamide for presurgical volume reduction in juvenile nasopharyngeal angiofibroma
    Alok Thakar
    Department of Otolaryngology and Head Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
    Head Neck 33:1747-53. 2011
    Although 2 studies totaling 11 cases have indicated some benefit of anti-androgen treatment with flutamide on juvenile nasopharyngeal angiofibroma (JNA), it is not part of contemporary practice.
  28. ncbi Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist
    M E Taplin
    University of Massachusetts Cancer Center, Worcester 01655, USA
    Cancer Res 59:2511-5. 1999
    ..Mutations were found in 5 of 16 patients who received combined androgen blockade with the AR antagonist flutamide, and these mutant ARs were strongly stimulated by flutamide...
  29. ncbi Exposure of juvenile guppies to three antiandrogens causes demasculinization and a reduced sperm count in adult males
    Mark Bayley
    Department of Zoology, Institute of Biological Sciences, University of Aarhus, Aarhus, Denmark
    Aquat Toxicol 56:227-39. 2002
    ..p,p'-DDE, can function as antiandrogens in mammals in a manner similar to the therapeutic antiandrogen flutamide. In mammals, these chemicals bind the androgen receptor and prevent the transcription of the associated genes ..
  30. ncbi Pioglitazone (7.5 mg/day) added to flutamide-metformin in women with androgen excess: additional increments of visfatin and high molecular weight adiponectin
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Clin Endocrinol (Oxf) 68:317-20. 2008
    Low-dose pioglitazone (Pio), flutamide (Flu), metformin (Met) plus an oestro-progestagen is a novel polytherapy lowering total and visceral adiposity, and reducing carotid intima media thickness (IMT) in hyperinsulinaemic women with ..
  31. ncbi Serum prostate specific antigen levels in women with polycystic ovary syndrome and the effect of flutamide+desogestrel/ethinyl estradiol combination
    M Bahceci
    Department of Endocrinology and Metabolism, Dicle University, School of Medicine, Diyarbakir, Turkey
    J Endocrinol Invest 27:353-6. 2004
    ..We aimed to determine serum PSA level in hirsute women and evaluate the effect of flutamide+desogestrel/ethynil estradiol combination.
  32. ncbi Metformin versus flutamide in the treatment of metabolic consequences of non-obese young women with polycystic ovary syndrome: a randomized prospective study
    I Sahin
    Department of Endocrinology and Metabolic Diseases, Faculty of Medicine, Inonu University, Malatya, Turkey
    Gynecol Endocrinol 19:115-24. 2004
    ..This study was designed to evaluate the effects of metformin and flutamide on metabolic parameters and insulin resistance in non-obese women with PCOS...
  33. ncbi Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1
    Huang Ping Yu
    University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall, Room G094, Birmingham, AL 35294 0019, USA
    J Leukoc Biol 79:277-84. 2006
    ..Previous studies have also shown that administration of flutamide up-regulated estrogen receptor (ER) expression in males following T-H...
  34. ncbi Flutamide as a preoperative treatment in juvenile angiofibroma (JA) with intracranial invasion: report of 7 cases
    Alberto Labra
    Department of Otolaryngology Head and Neck Surgery, General Hospital of Mexico, Mexico City, Mexico
    Otolaryngol Head Neck Surg 130:466-9. 2004
    To determine the efficacy of flutamide as a tumor reduction factor in patients who have juvenile angiofibroma (JA) with intracranial invasion.
  35. ncbi Suppressive effects of antiandrogens, finasteride and flutamide on development of prostatic lesions in a transgenic rat model
    Y M Cho
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya, Japan
    Prostate Cancer Prostatic Dis 10:378-83. 2007
    ..Finasteride and flutamide were administered to 10-week-old TG rats five times a week for 2, 5 and 7 weeks...
  36. doi Combined low-dose flutamide plus finasteride vs low-dose flutamide monotherapy for recurrent prostate cancer: a comparative analysis of two phase II trials with a long-term follow-up
    Lionel L Banez
    Division of Urologic Surgery and the Duke Prostate Center, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    BJU Int 104:310-4. 2009
    To compare the efficacy and tolerability of peripheral androgen blockade using combined low-dose flutamide plus finasteride vs low-dose flutamide monotherapy for treating biochemical relapse after the definitive management of prostate ..
  37. ncbi Neonatal treatment of rats with diethylstilboestrol (DES) induces stromal-epithelial abnormalities of the vas deferens and cauda epididymis in adulthood following delayed basal cell development
    Nina Atanassova
    Institute of Experimental Morphology and Anthropology, Bulgarian Academy of Science, Sofia, Bulgaria
    Reproduction 129:589-601. 2005
    ..However, suppression of testosterone production (GnRH antagonist treatment) or action (flutamide treatment) did not alter basal cell numbers...
  38. ncbi Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate
    V D Shultz
    CIIT Centers for Health Research, P.O. Box 12137, Research Triangle Park, NC 27709, USA
    Toxicol Sci 64:233-42. 2001
    ..Pregnant Sprague-Dawley rats received corn oil, DBP (500 mg/kg/day), or flutamide (reference antiandrogen, 50 mg/kg/day) by gavage daily from gestation day (GD) 12 to 21...
  39. ncbi Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in non-obese adolescents and women
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Hum Reprod Update 12:243-52. 2006
    ..At present, there is no approved therapy for PCOS. Recent studies indicate that a low-dose combination of flutamide (Flu; a generic androgen-receptor blocker) and metformin (Met; a generic insulin-sensitizer) normalizes the ..
  40. ncbi Flutamide-metformin plus an oral contraceptive (OC) for young women with polycystic ovary syndrome: switch from third- to fourth-generation OC reduces body adiposity
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Spain
    Hum Reprod 19:1725-7. 2004
    Low-dose flutamide-metformin has been developed as a background therapy for non-obese adolescents and young women with hyperinsulinaemic hyperandrogenism, a variant of polycystic ovary syndrome (PCOS)...
  41. ncbi Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and/or flutamide markedly reduces final sertoli cell number in the rat
    Sarah A Auharek
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom
    Endocrinology 151:2868-75. 2010
    ..This study addressed these questions and investigated whether continued maternal exposure to DBP or to flutamide from Pnd1-Pnd15 could prevent SC number compensation, because this would have implications for how sperm counts ..
  42. ncbi Flutamide-metformin plus ethinylestradiol-drospirenone for lipolysis and antiatherogenesis in young women with ovarian hyperandrogenism: the key role of early, low-dose flutamide
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 89:4716-20. 2004
    A low-dose combination of flutamide-metformin and ethinylestradiol-drospirenone was recently found to reduce the excess of total and abdominal fat, to diminish the deficit in lean mass, and to attenuate the dysadipocytokinemia of young ..
  43. ncbi Flutamide-metformin therapy to reduce fat mass in hyperinsulinemic ovarian hyperandrogenism: effects in adolescents and in women on third-generation oral contraception
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain
    J Clin Endocrinol Metab 88:4720-4. 2003
    ..The combination of flutamide (125-250 mg/d) and metformin has additive benefits on endocrine- metabolic indices in women with polycystic ..
  44. ncbi Comparison of anti-androgenic activity of flutamide, vinclozolin, procymidone, linuron, and p, p'-DDE in rodent 10-day Hershberger assay
    Il Hyun Kang
    Endocrine Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun dong, Eunpyung Ku, Seoul 122 704, South Korea
    Toxicology 199:145-59. 2004
    ..The aim of this study was to compare the anti-androgenic properties of flutamide, vinclozolin, procymidone, linuron, and p,p'-DDE in a 10-day Hershberger assay...
  45. ncbi Absence of hepatotoxicity after long-term, low-dose flutamide in hyperandrogenic girls and young women
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Hum Reprod 20:1833-6. 2005
    b>Flutamide is a pure non-steroidal anti-androgen that may be hepatotoxic, when given in high-dose (750 mg/d). Low- to ultralow-doses (250-62...
  46. ncbi Low-dose flutamide-metformin therapy reverses insulin resistance and reduces fat mass in nonobese adolescents with ovarian hyperandrogenism
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona 08950, Spain
    J Clin Endocrinol Metab 88:2600-6. 2003
    ..Combined antiandrogen (flutamide 250 mg/d) and insulin-sensitizing (metformin) therapy has beneficial effects, in particular on dyslipidemia and ..
  47. doi Inhibition of androgen receptor and Cdc25A phosphatase as a combination targeted therapy in molecular apocrine breast cancer
    Ali Naderi
    The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    Cancer Lett 298:74-87. 2010
    ..ERK phosphorylation using a Cdc25A phosphatase inhibitor, PM-20 in combination with AR inhibition using flutamide in this subtype...
  48. ncbi Effects of flutamide in the rat testis on the expression of occludin, an integral member of the tight junctions
    Myung Chan Gye
    Department of Life Science, College of Natural Sciences, Hanyang University, 133 791, Seoul, South Korea
    Toxicol Lett 143:217-22. 2003
    In an effort to uncover the gonadal impairment by the antiandrogen flutamide (FM) in males, the effect of subacute administration of FM on the expression of tight junction (TJ) genes that build the blood-testis barrier (BTB) was ..
  49. ncbi Low-dose pioglitazone, flutamide, metformin plus an estro-progestagen for non-obese young women with polycystic ovary syndrome: increasing efficacy and persistent safety over 30 months
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Gynecol Endocrinol 26:869-73. 2010
    ..4 year; BMI: 23.7 kg/m(2)) received metformin (850 mg/day), flutamide (62.5 mg/day), pioglitazone (7...
  50. doi Connexin 43 gene expression in male and female gonads of porcine offspring following in utero exposure to an anti-androgen, flutamide
    Malgorzata Durlej
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Acta Histochem 113:6-12. 2011
    The aim of this study was to show the effect of maternal exposure to flutamide on connexin 43 (Cx43) gene expression in testes and ovaries of 2-day-old piglets...
  51. ncbi Ethinylestradiol-drospirenone, flutamide-metformin, or both for adolescents and women with hyperinsulinemic hyperandrogenism: opposite effects on adipocytokines and body adiposity
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Déu L I, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 89:1592-7. 2004
    ..We studied the effects of two new treatment options, ethinylestradiol-drospirenone and flutamide-metformin, and of their combination on adipocytokinemia and body adiposity in adolescents and women with PCOS...
  52. ncbi Clinical outcome of maximum androgen blockade using flutamide as second-line hormonal therapy for hormone-refractory prostate cancer
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    BJU Int 96:791-5. 2005
    To investigate the efficacy of maximum androgen blockade (MAB) using flutamide as second-line hormonal therapy for advanced hormone-refractory prostate cancer (HRPC).
  53. ncbi Flutamide-metformin plus ethinylestradiol-drospirenone for lipolysis and antiatherogenesis in young women with ovarian hyperandrogenism: the key role of metformin at the start and after more than one year of therapy
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 90:39-43. 2005
    b>Flutamide (Flu)-metformin (Met) with ethinylestradiol-drospirenone is a combination therapy that reduces the total and abdominal fat excess, diminishes the lean mass deficit, and attenuates the dysadipocytokinemia of young and nonobese ..
  54. ncbi High neutrophil count in girls and women with hyperinsulinaemic hyperandrogenism: normalization with metformin and flutamide overcomes the aggravation by oral contraception
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Spain
    Hum Reprod 20:2457-62. 2005
    ..The endocrine hallmark of polycystic ovary syndrome (PCOS) is hyperinsulinaemic hyperandrogenism; another facet of PCOS is low-grade inflammation...
  55. ncbi Low-dose combination of flutamide, metformin and an oral contraceptive for non-obese, young women with polycystic ovary syndrome
    Lourdes Ibanez
    Hospital Sant Joan de Deu, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    Hum Reprod 18:57-60. 2003
    ..young women with polycystic ovary syndrome (PCOS) is normalized more effectively by combined treatment with flutamide and metformin than by either of these drugs in monotherapy...
  56. ncbi Treatment of hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism in nonobese, adolescent girls: effect of flutamide
    L Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Spain
    J Clin Endocrinol Metab 85:3251-5. 2000
    ..b>Flutamide, a nonsteroidal antiandrogen, is known to be effective in reducing hirsutism in patients with ovarian ..
  57. ncbi The model anti-androgen flutamide suppresses the expression of typical male stickleback reproductive behaviour
    Marion Sebire
    CEFAS Weymouth Laboratory, Environment and Animal Health, Barrack Road, The Nothe, Weymouth, Dorset DT4 8UB, UK
    Aquat Toxicol 90:37-47. 2008
    ..quiescent male sticklebacks that were simultaneously exposed for a 21-day period to the mammalian anti-androgen flutamide (FL) at 100, 500 and 1000 microg/l (plus a water control)...
  58. pmc Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening
    Kevin J Coe
    Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA
    Chem Res Toxicol 20:1277-90. 2007
    b>Flutamide (FLU) is an antiandrogen primarily used in the treatment of metastatic prostate cancer. It is an idiosyncratic hepatotoxicant that sometimes results in severe liver toxicity...
  59. pmc From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells
    S Yeh
    George Whipple Laboratory for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and the Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 96:5458-63. 1999
    ..Together, these data provide a novel pathway from HER2/Neu to AR transactivation, and they may represent one of the reasons for the PSA re-elevation and hormone resistance during androgen ablation therapy in prostate cancer patients...
  60. ncbi Androgen receptor independent cardiovascular action of the antiandrogen flutamide
    Radu Iliescu
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 81:420-7. 2003
    We have previously shown that flutamide (specific antagonist of the androgen receptor) has antihypertensive effects. In the present study we examined the mechanisms of flutamide action in the vasculature...
  61. ncbi Testosterone antagonist (flutamide) blocks ovulation and preovulatory surges of progesterone, luteinizing hormone and oestradiol in laying hens
    P L Rangel
    Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, Cd Universitaria
    Reproduction 131:1109-14. 2006
    ..Groups of laying hens (n = 10-22) were treated with the androgen receptor antagonist, flutamide, at 8 h intervals for 24 h at doses of 0, 31.25, 62.5, 125 and 250 mg. All doses reduced egg laying (P < 0...
  62. ncbi Anti-progestogenic effect of flutamide on uterine expression of calbindin-D9k mRNA and protein in immature mice
    Youn Kyu Ji
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
    Reprod Toxicol 22:694-701. 2006
    ..The induction of CaBP-9k can be employed as a biomarker for steroidal substrates as endocrine disruptors (EDs). Flutamide (FLU) is a non-steroidal anti-androgen or pro-drug that is rapidly metabolized to hydroxyflutamide, which may ..
  63. ncbi Changes in androgen-mediated reproductive development in male rat offspring following exposure to a single oral dose of flutamide at different gestational ages
    Paul M D Foster
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 85:1024-32. 2005
    Previous studies have indicated that the androgen receptor antagonist, flutamide, can produce a suite of reproductive malformations in the male rat when orally administered daily on gestation days (GD) 12-21...
  64. ncbi Androgen-dependent mechanisms of Wolffian duct development and their perturbation by flutamide
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    Endocrinology 147:4820-30. 2006
    ..The present study used in utero exposure of pregnant rats to the androgen receptor antagonist flutamide (50 or 100 mg/kg) to explore possible mechanisms. Pregnant rats were treated from embryonic d 15.5 (E15...
  65. ncbi Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study
    Alessandra Gambineri
    Division of Endocrinology, Department of Internal Medicine, S Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    J Clin Endocrinol Metab 91:3970-80. 2006
    The few controlled trials performed so far indicate that the addition of metformin and/or flutamide to a hypocaloric diet in obese women with polycystic ovary syndrome (PCOS) effectively influences different phenotypic aspects of the ..
  66. ncbi PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage
    Ya Ching Hsieh
    Center for Surgical Research, Univ of Alabama at Birmingham, 1670 Univ Blvd, Volker Hall, Rm G094, Birmingham, AL 35294 0019, USA
    Am J Physiol Heart Circ Physiol 289:H2665-72. 2005
    b>Flutamide, an androgen receptor antagonist, is thought to improve cardiovascular function by blocking the androgen receptor after trauma-hemorrhage (T-H)...
  67. ncbi Alteration of lactate production and transport in the adult rat testis exposed in utero to flutamide
    Isabelle Goddard
    Faculte de Medicine, Institut National de la Santé et de la Recherche Médicale INSERM U407, Lyon Sud, BP 12, F 69921 Oullins Cedex, France
    Mol Cell Endocrinol 206:137-46. 2003
    Although it is established that in utero exposure to the antiandrogen flutamide induces alteration of spermatogenesis in the adult rat testis offspring, the cellular and molecular mechanisms involved in such an effect remain to be ..
  68. ncbi Detection of the environmental antiandrogen p,p-DDE in CD and long-evans rats using a tier I screening battery and a Hershberger assay
    J C O'Connor
    DuPont Haskell Laboratory for Toxicology and Industrial Medicine, Newark, Delaware 19714, USA
    Toxicol Sci 51:44-53. 1999
    ..However, a Tier I screening battery consisting of both in vivo and in vitro endpoints would reduce the chance that weak-acting compounds such as p,p'-DDE would not be identified as potential EACs...
  69. ncbi Alterations of gene expression in adult male rat testis and pituitary shortly after subacute administration of the antiandrogen flutamide
    Seiichiroh Ohsako
    Molecular and Cellular Toxicology Section, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    J Reprod Dev 49:275-90. 2003
    ..or pituitary of adult rats were examined shortly after subacute administration of the well-known anti-androgen, flutamide (FM). FM (25 mg/kg/day) was orally administered to male rats for six days...
  70. ncbi Intrahippocampal administration of an androgen receptor antagonist, flutamide, can increase anxiety-like behavior in intact and DHT-replaced male rats
    Kassandra L Edinger
    Department of Biological Sciences, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Horm Behav 50:216-22. 2006
    ..at intracellular androgen receptors in the hippocampus, then administration of an androgen receptor antagonist, flutamide, directly to the hippocampus should increase anxiety-like behavior of intact and DHT-replaced, but not GDX, male ..
  71. ncbi Effects of prenatal flutamide on testicular development, androgen production and fertility in rats
    Hamit Okur
    Department of Pediatric Surgery, Erciyes University School of Medicine, Kayseri, Turkey
    Urol Int 76:130-3. 2006
    To investigate the effects of blocking prenatal androgen with the anti-androgen flutamide on testicular weight (TW), seminiferous tubular diameter (STD), testicular biopsy score (TBS), testicular testosterone (TT), and fertility.
  72. ncbi Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1
    Ya Ching Hsieh
    Center for Surgical Research, Univ of Alabama at Birmingham, 1670 Univ Boulevard, Birmingham Alabama 35294 0019, USA
    Am J Physiol Heart Circ Physiol 290:H416-23. 2006
    Although previous studies have shown that flutamide improves cardiovascular function after trauma-hemorrhage, the mechanisms responsible for the salutary effect remain unknown...
  73. ncbi Saccharomyces cerevisiae intervention for relieving flutamide-induced hepatotoxicity in male rats
    F Mannaa
    Medical Physiology Department, National Research Centre, Dokki, Giza, Egypt
    Pharmazie 60:689-95. 2005
    ..the protective role of baker's yeast Saccharomyces cerevisiae against the hepatotoxic effect of the drug flutamide that is widely used for treatment of metastatic prostate adenocarcinoma...
  74. ncbi Discontinuous low-dose flutamide-metformin plus an oral or a transdermal contraceptive in patients with hyperinsulinaemic hyperandrogenism: normalizing effects on CRP, TNF-alpha and the neutrophil/lymphocyte ratio
    Lourdes Ibanez
    Endocrinology Unit and Hormonal Laboratory, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Hum Reprod 21:451-6. 2006
    Low-dose flutamide-metformin (Flu-Met) with an oral contraceptive is a therapeutic option for women with hyperinsulinaemic hyperandrogenism...
  75. ncbi Short-term androgen deprivation and radiotherapy for locally advanced prostate cancer: results from the Trans-Tasman Radiation Oncology Group 96.01 randomised controlled trial
    James W Denham
    Newcastle Mater Hospital, Newcastle, New South Wales, Australia
    Lancet Oncol 6:841-50. 2005
    ..We did a large randomised controlled trial to determine whether 3 months or 6 months of androgen deprivation given before and during radiotherapy improves outcomes for patients with locally advanced prostate cancer...
  76. ncbi Imaging androgen receptor function during flutamide treatment in the LAPC9 xenograft model
    Romyla Ilagan
    Department of Biological Chemistry, School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, CHS 33 142, Los Angeles, California 90095 1737, USA
    Mol Cancer Ther 4:1662-9. 2005
    ..a novel androgen receptor-specific molecular imaging system is able to detect the action of the antiandrogen flutamide on androgen receptor function in xenograft models of prostate cancer...
  77. ncbi Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues
    B S McIntyre
    CIIT Centers for Health Research, Six Davis Drive, P. O. Box 12137, Research Triangle Park, NC 27709-2137, USA
    Toxicol Sci 62:236-49. 2001
    ..The objectives of this study were to determine whether in utero exposure to flutamide results in permanent changes in male AGD and nipple retention, characterize the dose-response relationship ..
  78. ncbi Androgen receptor antagonism by the organophosphate insecticide fenitrothion
    H Tamura
    Department of Applied Biochemistry, Meijo University, Nagoya 468-8502, Japan
    Toxicol Sci 60:56-62. 2001
    ..An additional group of rats was given testosterone propionate and flutamide (50 mg/kg/day). Motor activity and acetylcholinesterase activity in whole blood and brain were also assessed...
  79. ncbi Flutamide, testolactone, and reduced hydrocortisone dose maintain normal growth velocity and bone maturation despite elevated androgen levels in children with congenital adrenal hyperplasia
    D P Merke
    Warren Grant Magnuson Clinical Center, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda Maryland 20892 1862, USA
    J Clin Endocrinol Metab 85:1114-20. 2000
    ..maturation in a short term cross-over study of a new four-drug treatment regimen containing an antiandrogen (flutamide), an inhibitor of androgen to estrogen conversion (testolactone), reduced hydrocortisone dose, and ..
  80. ncbi Inhibition of PSA flare in prostate cancer patients by administration of flutamide for 2 weeks before initiation of treatment with slow-releasing LH-RH agonist
    K Noguchi
    Department of Urology, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Int J Clin Oncol 6:29-33. 2001
    A prospective randomized study was designed to determine whether flutamide (FLU) administered before treatment with a luteinizing hormone-releasing hormone agonist (LH-RHa) prevented prostate-specific antigen (PSA) flare in prostate ..
  81. ncbi Impaired male sexual development in perinatal Sprague-Dawley and Long-Evans hooded rats exposed in utero and lactationally to p,p'-DDE
    L You
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 45:162-73. 1998
    ....
  82. ncbi Differential effects of flutamide and di-(2-ethylhexyl) phthalate on male reproductive organs in a rat model
    Thuy T B Vo
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Chungbuk, Korea
    J Reprod Dev 55:400-11. 2009
    ..In the present study, pregnant Sprague Dawley (SD) rats were treated with testosterone propionate (TP), flutamide (Flu) and di-(2-ethylhexyl) phthalate (DEHP) from gestation days (GD) 11 to 21...
  83. ncbi Long-term apoptotic cell death process with increased expression and activation of caspase-3 and -6 in adult rat germ cells exposed in utero to flutamide
    Asma Omezzine
    Institut National de la Santé et de la Recherche Médicale Unité 407, Faculté de médecine Lyon Sud, 69921 Oullins, France
    Endocrinology 144:648-61. 2003
    Although it is established that in utero exposure to antiandrogenic compounds such as flutamide induces hypospermatogenesis in adult male rat offspring, the cellular and molecular mechanisms remain to be investigated...
  84. ncbi Review of the histological effects of the anti-androgen, flutamide, on mouse testis
    Reiko Anahara
    Faculty of Health Sciences, Ryotokuji University, 5 8 1, Akemi, Urayasu, Chiba 279 8567, Japan
    Reprod Toxicol 25:139-43. 2008
    This is a mini-review summarizing recent findings on the effect of flutamide (FLUT), an anti-androgenic toxicant, on the mouse testis, particularly on the ectoplasmic specialization (ES) in the testis...
  85. ncbi In vivo and in vitro effects of flutamide and diethylstilbestrol on fetal testicular steroidogenesis in the rat
    N Annika Adamsson
    Department of Physiology, University of Turku, 20520 Turku, Finland
    Reprod Toxicol 25:76-83. 2008
    ..In this study, we have investigated in utero and in vitro effects of flutamide (FLU) and diethylstilbestrol (DES) on fetal rat testicular steroidogenesis...
  86. ncbi Up-regulation of circadian clock gene Period 2 in the prostate mesenchymal cells during flutamide-induced apoptosis
    Kaoru Yoshida
    Department of Animal and Marine Bioresource Sciences, Faculty of Agriculture, Kyushu University, Fukuoka shi, Fukuoka 812 8581, Japan
    Mol Cell Biochem 335:37-45. 2010
    ..Conversely, flutamide (FL) up-regulated the amplitude of circadian Per2-dLuc oscillations in a dose-dependent manner, whereas T ..
  87. ncbi A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor
    Yi Cai
    George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Cancer 123:195-201. 2008
    ..Together, these findings provide a possible explanation how CAB with antiandrogen HF therapy might fail and provide a potential new therapeutic approach to battle prostate cancer via combination of CAB therapy with COX-2 inhibitor(s)...
  88. ncbi Evaluation of the antiandrogenic effects of flutamide, DDE, and linuron in the weanling rat assay using organ weight, histopathological, and proteomic approaches
    Helen Tinwell
    Department of Research Toxicology, Bayer CropScience, 06903 Sophia Antipolis, France
    Toxicol Sci 100:54-65. 2007
    ..in our laboratory at several dose levels in the testosterone propionate (TP)-stimulated weanling using flutamide (FM) as a positive control...
  89. ncbi Induction of reproductive tract developmental abnormalities in the male rat by lowering androgen production or action in combination with a low dose of diethylstilbestrol: evidence for importance of the androgen-estrogen balance
    Ana Rivas
    Medical Research Council Human Reproductive Sciences Unit, Center for Reproductive Biology, University of Edinburgh Academic Center, Edinburgh, United Kingdom EH16 4SB
    Endocrinology 143:4797-808. 2002
    ..with a treatment to suppress either androgen production [GnRH antagonist (GnRHa)] or androgen action (flutamide); other rats were treated with GnRHa or flutamide alone...
  90. ncbi Flutamide versus orchidectomy in the treatment of metastatic prostate carcinoma
    L Boccon-Gibod
    CHU Bichat, Department of Urology, Paris, France
    Eur Urol 32:391-5; discussion 395-6. 1997
    To compare in a randomized clinical trial the therapeutic efficacy of the nonsteroidal antiandrogen flutamide 250 mg tid to testicular androgen suppression by orchidectomy in patients with metastatic prostate cancer.
  91. ncbi Vinclozolin and p,p'-DDE alter androgen-dependent gene expression: in vivo confirmation of an androgen receptor-mediated mechanism
    W R Kelce
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Appl Pharmacol 142:192-200. 1997
    ..for 4 days with vehicle (corn oil), vinclozolin (200 mg/kg/day), p,p'-DDE (200 mg/kg/day), or the antiandrogen flutamide (100 mg/kg/day) as a positive control...
  92. ncbi Endocrine active agents: implications of adverse and non-adverse changes
    Paul M D Foster
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Pathol 30:59-65. 2002
    ....
  93. ncbi Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 male rats
    Kaori Miyata
    Environmental Health Science Lab, Sumitomo Chemical Co, Ltd, 3 1 98, Kasugade Naka, Konohana ku, Osaka 554 8558, Japan
    J Toxicol Sci 27:19-33. 2002
    b>Flutamide, which has antiandrogenic properties, was administered to pregnant rats, and effects on male offspring were examined. Crj: CD (SD) IGS (SPF) females were administered flutamide (0.15, 0.6, 2.5, 10.0, 100 mg/kg, p.o...
  94. ncbi Hydroxypropyl-beta-cyclodextrin-flutamide inclusion complex. II. Oral and intravenous pharmacokinetics of flutamide in the rat
    Zhong Zuo
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Pharm Pharm Sci 5:292-8. 2002
    The objective of this work was to determine the pharmacokinetics of flutamide (FLT) and its active metabolite, 2-hydroxy-flutamide (FLT-2-OH) in rats, following formulation in hydroxypropyl-Beta-cyclodextrin (FLT-HPBetaCyD).
  95. ncbi Intermittent androgen castration: a biological reality during intermittent treatment in metastatic prostate cancer?
    N Mottet
    Urology Department, Clinique Mutualiste, Saint Etienne, France
    Urol Int 75:204-8. 2005
    ..To assess the effects of intermittent maximal androgen blockade (IMAB) on testosterone (T) levels during on- and off-treatment periods...
  96. doi Computationally identified novel diphenyl- and phenylpyridine androgen receptor antagonist structures
    Annu A Söderholm
    CSC Scientific Computing Ltd, PO Box 405, FI 02101 Espoo, Finland
    J Chem Inf Model 48:1882-90. 2008
    ..Compounds could serve as a novel platform to develop more potent AR antagonists with inhibitory activity in both wild-type and T877A mutant AR...
  97. ncbi A phase II study of nilutamide in men with prostate cancer after the failure of flutamide or bicalutamide therapy
    Nancy B Davis
    Division of Neoplastic Diseases and Related Disorders, Medical College of Wisconsin, Milwaukee, WI, USA
    BJU Int 96:787-90. 2005
    To determine the prostate-specific antigen (PSA) response and time to PSA or radiographic progression in men with prostate cancer refractory to bicalutamide and/or flutamide therapy.
  98. pmc Acquisition of androgen independence by human prostate epithelial cells during arsenic-induced malignant transformation
    Lamia Benbrahim-Tallaa
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 113:1134-9. 2005
    ..The precise manner in which arsenic altered CAsE-PE growth and progression is undefined but may involve a bypass of AR involving direct stimulation of downstream signaling pathways...
  99. ncbi Persistent prostate-specific antigen expression after neoadjuvant androgen depletion: an early predictor of relapse or incomplete androgen suppression
    Charles J Ryan
    Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Urology 68:834-9. 2006
    ..To analyze post-androgen depletion (AD) primary tumors to identify markers of treatment failure because AD does not reduce the probability of prostate-specific antigen (PSA) failure after prostatectomy...
  100. ncbi Androgens augment the mitogenic effects of oocyte-secreted factors and growth differentiation factor 9 on porcine granulosa cells
    T E Hickey
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, Woodville, South Australia
    Biol Reprod 73:825-32. 2005
    ..These signaling pathways are likely to be important regulators of folliculogenesis in vivo, and may contribute to the excess follicle growth that is observed in androgen-treated female animals...
  101. ncbi Does small-cell phenotype predict the natural history of prostate cancer? A case study in disease behavior
    Susan F Slovin
    Genitourinary Oncology Service, Sidney Kimmel Center for Prostate and Urologic Cancers, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nat Clin Pract Oncol 4:551-4. 2007
    ..One should be alerted to this phenotype in a patient with large volume disease on biopsy or examination and a low PSA or PSA not in proportion to tumor burden...

Research Grants73

  1. Testosterone stimulation of insulin signalingin adipocytes
    Wayne E Taylor; Fiscal Year: 2010
    ..of androgen receptor stimulates glucose uptake in 3T3-L1 adipocytes by using the specific AR antagonists flutamide or bicalutamide to inhibit AR activation during the glucose uptake assay...
  2. Testosterone stimulation of insulin signalingin adipocytes
    Wayne Taylor; Fiscal Year: 2009
    ..of androgen receptor stimulates glucose uptake in 3T3-L1 adipocytes by using the specific AR antagonists flutamide or bicalutamide to inhibit AR activation during the glucose uptake assay...
  3. Hormonal Mechanisms of Postmenopausal Hypertension
    JANE RECKELHOFF; Fiscal Year: 2005
    ..In PM SHR, serum testosterone is increased, and in preliminary studies flutamide, an androgen receptor antagonist, reduces blood pressure...
  4. Hormonal Mechanisms of Postmenopausal Hypertension
    JANE RECKELHOFF; Fiscal Year: 2004
    ..In PM SHR, serum testosterone is increased, and in preliminary studies flutamide, an androgen receptor antagonist, reduces blood pressure...
  5. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2001
    ..dose is ineffective, multiple doses of these drugs with or without gonadotropin releasing hormone (GnRH) or flutamide (androgen receptor antagonist) will be administered to determine whether synergistic beneficial effects on ..
  6. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2000
    ..dose is ineffective, multiple doses of these drugs with or without gonadotropin releasing hormone (GnRH) or flutamide (androgen receptor antagonist) will be administered to determine whether synergistic beneficial effects on ..
  7. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2002
    ..dose is ineffective, multiple doses of these drugs with or without gonadotropin releasing hormone (GnRH) or flutamide (androgen receptor antagonist) will be administered to determine whether synergistic beneficial effects on ..
  8. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2002
    ..dose is ineffective, multiple doses of these drugs with or without gonadotropin releasing hormone (GnRH) or flutamide (androgen receptor antagonist) will be administered to determine whether synergistic beneficial effects on ..
  9. Maintainance of Organ Function Following Injury
    Irshad Chaudry; Fiscal Year: 2006
    ..Alternatively, administration of flutamide, an androgen antagonist (AA), after hemorrhage-resuscitation in non-castrated rats improves the depressed ..
  10. Developmental programming: influence of sex steroids and mechanisms
    Chandrasekhar Yallampalli; Fiscal Year: 2011
    ..the onset and severity of hypertension, and these changes are reversed by respective steroid replacement and flutamide. Growth rate, adiposity, and changes in MAP and plasma T and E2 will be assessed...
  11. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2000
    ..dose is ineffective, multiple doses of these drugs with or without gonadotropin releasing hormone (GnRH) or flutamide (androgen receptor antagonist) will be administered to determine whether synergistic beneficial effects on ..
  12. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 1999
    ..dose is ineffective, multiple doses of these drugs with or without gonadotropin releasing hormone (GnRH) or flutamide (androgen receptor antagonist) will be administered to determine whether synergistic beneficial effects on ..
  13. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2001
    ..Alternatively, administration of flutamide, an androgen antagonist (AA), after hemorrhage-resuscitation in non-castrated rats improves the depressed ..
  14. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2000
    ..Alternatively, administration of flutamide, an androgen antagonist (AA), after hemorrhage-resuscitation in non-castrated rats improves the depressed ..
  15. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2003
    ..Alternatively, administration of flutamide, an androgen antagonist (AA), after hemorrhage-resuscitation in non-castrated rats improves the depressed ..
  16. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2000
    ..Alternatively, administration of flutamide, an androgen antagonist (AA), after hemorrhage-resuscitation in non-castrated rats improves the depressed ..
  17. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2002
    ..Alternatively, administration of flutamide, an androgen antagonist (AA), after hemorrhage-resuscitation in non-castrated rats improves the depressed ..
  18. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 1999
    ..Alternatively, administration of flutamide, an androgen antagonist (AA), after hemorrhage-resuscitation in non-castrated rats improves the depressed ..
  19. STEROID HORMONES AND NEURONAL REGENERATION
    Kathryn Jones; Fiscal Year: 2000
    ..Two series of experiments will be done. The effects of high doses of E in the presence of the anti-androgen, flutamide, and high versus low doses of E on the rate of regeneration will be determined...
  20. STEROID HORMONES AND NEURONAL REGENERATION
    Kathryn Jones; Fiscal Year: 1999
    ..Two series of experiments will be done. The effects of high doses of E in the presence of the anti-androgen, flutamide, and high versus low doses of E on the rate of regeneration will be determined...
  21. STEROID HORMONES AND NEURONAL REGENERATION
    Kathryn Jones; Fiscal Year: 2000
    ..Two series of experiments will be done. The effects of high doses of E in the presence of the anti-androgen, flutamide, and high versus low doses of E on the rate of regeneration will be determined...
  22. STEROID HORMONES AND NEURONAL REGENERATION
    Kathryn Jones; Fiscal Year: 2001
    ..Two series of experiments will be done. The effects of high doses of E in the presence of the anti-androgen, flutamide, and high versus low doses of E on the rate of regeneration will be determined...
  23. STEROID HORMONES AND NEURONAL REGENERATION
    Kathryn Jones; Fiscal Year: 2001
    ..Two series of experiments will be done. The effects of high doses of E in the presence of the anti-androgen, flutamide, and high versus low doses of E on the rate of regeneration will be determined...
  24. Maintainance of Organ Function Following Injury
    Irshad Chaudry; Fiscal Year: 2007
    ..Alternatively, administration of flutamide, an androgen antagonist (AA), after hemorrhage-resuscitation in non-castrated rats improves the depressed ..
  25. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2003
    ..Some groups will also receive treatment with testosterone, flutamide, an androgen receptor blocker, or finasteride, which blocks conversion of testosterone to dihydrotestosterone...
  26. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2005
    ..Some groups will also receive treatment with testosterone, flutamide, an androgen receptor blocker, or finasteride, which blocks conversion of testosterone to dihydrotestosterone...
  27. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2004
    ..Some groups will also receive treatment with testosterone, flutamide, an androgen receptor blocker, or finasteride, which blocks conversion of testosterone to dihydrotestosterone...
  28. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2002
    ..Some groups will also receive treatment with testosterone, flutamide, an androgen receptor blocker, or finasteride, which blocks conversion of testosterone to dihydrotestosterone...
  29. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2004
    ..Some groups will also receive treatment with testosterone, flutamide, an androgen receptor blocker, or finasteride, which blocks conversion of testosterone to dihydrotestosterone...
  30. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2001
    ..Some groups will also receive treatment with testosterone, flutamide, an androgen receptor blocker, or finasteride, which blocks conversion of testosterone to dihydrotestosterone...
  31. A Novel Synthetic Androgen Receptor Antagonist
    Zhongyun Dong; Fiscal Year: 2009
    ..prostate cancer cell lines tested, including androgen-independent cells and cells resistant to antiandrogens, flutamide (Flut) or nilutamide (Nilut)...
  32. A Novel Synthetic Androgen Receptor Antagonist
    Zhongyun Dong; Fiscal Year: 2010
    ..prostate cancer cell lines tested, including androgen-independent cells and cells resistant to antiandrogens, flutamide (Flut) or nilutamide (Nilut)...
  33. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad H Chaudry; Fiscal Year: 2010
    ..findings that 17p-estradiol (E2) has the unique ability to protect immune cell responses following T-H, and that flutamide [androgen receptor (AR) antagonist] also utilizes E2-mediated pathway in restoring immune functions in males, ..
  34. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2007
    ..findings that 17p-estradiol (E2) has the unique ability to protect immune cell responses following T-H, and that flutamide [androgen receptor (AR) antagonist] also utilizes E2-mediated pathway in restoring immune functions in males, ..
  35. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2009
    ..findings that 17p-estradiol (E2) has the unique ability to protect immune cell responses following T-H, and that flutamide [androgen receptor (AR) antagonist] also utilizes E2-mediated pathway in restoring immune functions in males, ..
  36. Androgens and Hypothalamic Sensitivity to Progesterone Feedback in Female Puberty
    Susan Blank; Fiscal Year: 2007
    ..Treatment with the androgen receptor blocker flutamide restores hypothalamic sensitivity to P in women with PCOS, indicating that androgens mediate hypothalamic P ..
  37. Regulation of Epididymal Luminal Acidification
    Nuria Pastor Soler; Fiscal Year: 2006
    ..evaluate the effects of steroid hormone agonists and antagonists (DES, ethinyl estradiol, GnRH antagonist and flutamide) and toxic compounds (Cadmium and Lead) have on the epididymal cellular profile, protein expression, H+ATPase ..
  38. Regulation of Epididymal Luminal Acidification
    Nuria Pastor Soler; Fiscal Year: 2005
    ..evaluate the effects of steroid hormone agonists and antagonists (DES, ethinyl estradiol, GnRH antagonist and flutamide) and toxic compounds (Cadmium and Lead) have on the epididymal cellular profile, protein expression, H+ATPase ..
  39. Regulation of Epididymal Luminal Acidification
    Nuria Pastor Soler; Fiscal Year: 2007
    ..evaluate the effects of steroid hormone agonists and antagonists (DES, ethinyl estradiol, GnRH antagonist and flutamide) and toxic compounds (Cadmium and Lead) have on the epididymal cellular profile, protein expression, H+ATPase ..
  40. Regulation of Epididymal Luminal Acidification
    Nuria Pastor Soler; Fiscal Year: 2004
    ..evaluate the effects of steroid hormone agonists and antagonists (DES, ethinyl estradiol, GnRH antagonist and flutamide) and toxic compounds (Cadmium and Lead) have on the epididymal cellular profile, protein expression, H+ATPase ..
  41. BEHAVIORAL DEVELOPMENT: PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 2000
    ..Endogenous prenatal androgen effects were reduced by twice daily administration of flutamide, and androgen-receptor blocker. Weekly injections of testosterone enanthate increased androgen...
  42. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad H Chaudry; Fiscal Year: 2010
    ..Furthermore, administration of AR antagonist flutamide in males after T-H normalized cardiac E2 levels, ER levels, mitochondrial ATP levels, and cardiac functions...
  43. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2009
    ..Furthermore, administration of AR antagonist flutamide in males after T-H normalized cardiac E2 levels, ER levels, mitochondrial ATP levels, and cardiac functions...
  44. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2006
    ..involving both Nissl stains and ICC for various neuropeptides, will examine fetal and adult tissues from the hyena CNS, including tissues derived from mature hyenas that were exposed to flutamide/finasteride in utero.
  45. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2005
    ..involving both Nissl stains and ICC for various neuropeptides, will examine fetal and adult tissues from the hyena CNS, including tissues derived from mature hyenas that were exposed to flutamide/finasteride in utero.
  46. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2004
    ..involving both Nissl stains and ICC for various neuropeptides, will examine fetal and adult tissues from the hyena CNS, including tissues derived from mature hyenas that were exposed to flutamide/finasteride in utero.
  47. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2002
    ..involving both Nissl stains and ICC for various neuropeptides, will examine fetal and adult tissues from the hyena CNS, including tissues derived from mature hyenas that were exposed to flutamide/finasteride in utero.
  48. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2003
    ..involving both Nissl stains and ICC for various neuropeptides, will examine fetal and adult tissues from the hyena CNS, including tissues derived from mature hyenas that were exposed to flutamide/finasteride in utero.
  49. INFLAMMATION AND DRUG IDIOSYNCRASY
    Robert Roth; Fiscal Year: 2006
    ..Several drugs that have caused idiosyncratic liver injury in humans (chlorpromazine, ranitidine, flutamide) and two that have not (promethazine, famotidine) will be used...
  50. INFLAMMATION AND DRUG IDIOSYNCRASY
    Robert Roth; Fiscal Year: 2005
    ..Several drugs that have caused idiosyncratic liver injury in humans (chlorpromazine, ranitidine, flutamide) and two that have not (promethazine, famotidine) will be used...
  51. INFLAMMATION AND DRUG IDIOSYNCRASY
    Robert Roth; Fiscal Year: 2003
    ..Several drugs that have caused idiosyncratic liver injury in humans (chlorpromazine, ranitidine, flutamide) and two that have not (promethazine, famotidine) will be used...
  52. INFLAMMATION AND DRUG IDIOSYNCRASY
    Robert Roth; Fiscal Year: 2004
    ..Several drugs that have caused idiosyncratic liver injury in humans (chlorpromazine, ranitidine, flutamide) and two that have not (promethazine, famotidine) will be used...
  53. ANDROGEN BIOLOGY TO FETAL LUNG DEVELOPMENT
    John Torday; Fiscal Year: 1999
    ..The anti-androgenic effects of these progestins will be compared with the potent anti-androgen Flutamide, which effectively reverses the androgen inhibition of glucocorticoid-stimulated surfactant production...
  54. Efficacy and Mechanism of Novel Androgen Receptor Inhibitors
    Marc Diamond; Fiscal Year: 2009
    ..compounds function as non-competitive antagonists, and synergize with classical anti-androgens such as hydroxy-flutamide or bicalutamide...
  55. Efficacy and Mechanism of Novel Androgen Receptor Inhibitors
    Marc I Diamond; Fiscal Year: 2010
    ..compounds function as non-competitive antagonists, and synergize with classical anti-androgens such as hydroxy-flutamide or bicalutamide...
  56. PILOT--Molecular Recognition of Biomolecules by Metal Complexes: Host-Guest Chem
    JUDITH WALMSLEY; Fiscal Year: 2003
    ..and Pt(ll) and their host-guest complexes in which the guest is a known antitumor drug, such as altetramide or flutamide, will be investigated...
  57. Androgen resistance in prostate cancer progression
    DIANE ROBINS; Fiscal Year: 2003
    ..Our specific hypotheses are that: 1) The commonly used antagonists, bicalutamide and flutamide, differ in their precise mechanism of action, and thus mutant ARs resistant to one may not have a similar ..
  58. Mechanism of Estrogen-Induced Penile Dysfunction and Loss of Fertility
    HARI OM GOYAL; Fiscal Year: 2010
    ..Specific aim 3 will test the hypothesis that exposure to anti-androgens (GnRH-antagonist and flutamide) up-regulates ER1 expression because of lower androgenic action, but may not alter PPAR3, C/EBP1, 1 actin, and ..
  59. COMBINED MODALITY APPROACH FOR PROSTATE CANCER
    William Fair; Fiscal Year: 1992
    ..trial comparing final pathologic stage of disease between the study group receiving 3 months of Zoladex and Flutamide treatment followed by radical prostatectomy versus the control group undergoing radical prostatectomy alone...
  60. Fetal Basis of Sexual Dysfunction: Brain Differentiation
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..animals will be compared with animals treated with the well characterized androgen receptor antagonist flutamide to test the hypotheses that alterations in the GnRH neuronal system and alterations in the chemoarchitecture of ..
  61. Fetal Basis of Sexual Dysfunction: Brain Differentiation
    D N Rao Veeramachaneni; Fiscal Year: 2006
    ..animals will be compared with animals treated with the well characterized androgen receptor antagonist flutamide to test the hypotheses that alterations in the GnRH neuronal system and alterations in the chemoarchitecture of ..
  62. REGULATION OF GNRH DRIVE IN PCOS
    Sarah Berga; Fiscal Year: 2000
    ..LH pulse frequency and reduced LH secretion by: [1] reducing androgen action with the androgen receptor blocker, flutamide; [2] by improving insulin resistance insulin resistance with the insulin sensitizer, troglitazone; and [3] by ..
  63. BEHAVIORAL DEVELOPMENT--PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 2000
    ..Prenatal androgen exposure was reduced by twice daily administration of flutamide, an androgen receptor blocker. Weekly injections of testosterone enanthate were used to increase androgen...
  64. Application of Metabonomics in Predictive Toxicology
    Sidney Nelson; Fiscal Year: 2009
    ..to a regioisomer that causes intrinsic hepatocellular injury, and 3) of the nitroaromafic anti-androgen drug, flutamide, an idiosyncratic hepatotoxicant, to its less toxic cyano analogue...
  65. BEHAVIORAL DEVELOPMENT--PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 2001
    ..Prenatal androgen exposure was reduced by twice daily administration of flutamide, an androgen receptor blocker. Weekly injections of testosterone enanthate were used to increase androgen...
  66. BEHAVIORAL DEVELOPMENT--PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 1999
    ..Prenatal androgen exposure was reduced by twice daily administration of flutamide, an androgen receptor blocker. Weekly injections of testosterone enanthate were used to increase androgen...
  67. Application of Metabonomics in Predictive Toxicology
    SIDNEY DONALD NELSON; Fiscal Year: 2009
    ..to a regioisomer that causes intrinsic hepatocellular injury, and 3) of the nitroaromafic anti-androgen drug, flutamide, an idiosyncratic hepatotoxicant, to its less toxic cyano analogue...
  68. MALE PSEUDOHERMAPHRODITISM--THE BIOLOGY OF ANDROGENS
    Julianne Imperato McGinley; Fiscal Year: 1992
    ..Comparison studies will be carried out with the antiandrogen, flutamide, which blocks the action of both T and DHT...
  69. MALE PSEUDOHERMAPHRODITISM--THE BIOLOGY OF ANDROGENS
    Julianne Imperato McGinley; Fiscal Year: 1990
    ..Comparison studies will be carried out with the antiandrogen, flutamide, which blocks the action of both T and DHT...
  70. METABOLIC IMAGING OF THE PROSTATE USING 3D MRSI
    Daniel Vigneron; Fiscal Year: 2000
    ..hormonal ablation therapy with the LH-RH agonist Zoladex, which causes medical castration, and the anti-androgen flutamide, which inhibits androgen uptake and/or binding to the nuclear receptor...
  71. METABOLIC IMAGING OF THE PROSTATE USING 3D MRSI
    Daniel Vigneron; Fiscal Year: 1999
    ..hormonal ablation therapy with the LH-RH agonist Zoladex, which causes medical castration, and the anti-androgen flutamide, which inhibits androgen uptake and/or binding to the nuclear receptor...