flutamide

Summary

Summary: An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Top Publications

  1. ncbi Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females
    Frank Hildebrand
    Department of Surgery, University of Alabama at Birmingham, AL 35294 0019, USA
    J Leukoc Biol 80:759-65. 2006
  2. ncbi Flutamide and cyproterone acetate exert agonist effects: induction of androgen receptor-dependent neuroprotection
    Thuy Vi V Nguyen
    University of Southern California, Davis School of Gerontology, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Endocrinology 148:2936-43. 2007
  3. ncbi Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues
    B S McIntyre
    CIIT Centers for Health Research, Six Davis Drive, P. O. Box 12137, Research Triangle Park, NC 27709-2137, USA
    Toxicol Sci 62:236-49. 2001
  4. pmc From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells
    S Yeh
    George Whipple Laboratory for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and the Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 96:5458-63. 1999
  5. ncbi Change of the cell cycle after flutamide treatment in prostate cancer cells and its molecular mechanism
    Yong Wang
    Department of Urology, Tangdu Hospital, China
    Asian J Androl 7:375-80. 2005
  6. ncbi Are expression and localization of tight and adherens junction proteins in testes of adult boar affected by foetal and neonatal exposure to flutamide?
    A Hejmej
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Int J Androl 35:340-52. 2012
  7. ncbi Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors
    Abolhassan Ahmadiani
    Neuroscience Center, Shaheed Beheshti University of Medical Sciences, Tehran 13164, Iran
    Epilepsia 44:629-35. 2003
  8. ncbi Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity
    Rohini Kashimshetty
    University of Connecticut School of Pharmacy, Department of Pharmaceutical Sciences, Storrs, CT 06269, USA
    Toxicol Appl Pharmacol 238:150-9. 2009
  9. ncbi Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells
    Nicola J Mabjeesh
    Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 9:2416-25. 2003
  10. ncbi Lyophilization monophase solution technique for improvement of the physicochemical properties of an anticancer drug, flutamide
    Nazik Elgindy
    Department of Industrial Pharmacy, University of Alexandria, Alexandria, Egypt
    Eur J Pharm Biopharm 74:397-405. 2010

Detail Information

Publications238 found, 100 shown here

  1. ncbi Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females
    Frank Hildebrand
    Department of Surgery, University of Alabama at Birmingham, AL 35294 0019, USA
    J Leukoc Biol 80:759-65. 2006
    We hypothesized that administration of androgen receptors antagonist flutamide following trauma-hemorrhage (T-H) in metestrus females will maintain immune function and reduce remote organ damage under those conditions...
  2. ncbi Flutamide and cyproterone acetate exert agonist effects: induction of androgen receptor-dependent neuroprotection
    Thuy Vi V Nguyen
    University of Southern California, Davis School of Gerontology, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Endocrinology 148:2936-43. 2007
    ..Here we investigated the effects of the antiandrogens flutamide and cyproterone acetate on neuroprotection induced by dihydrotestosterone (DHT)...
  3. ncbi Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues
    B S McIntyre
    CIIT Centers for Health Research, Six Davis Drive, P. O. Box 12137, Research Triangle Park, NC 27709-2137, USA
    Toxicol Sci 62:236-49. 2001
    ..The objectives of this study were to determine whether in utero exposure to flutamide results in permanent changes in male AGD and nipple retention, characterize the dose-response relationship ..
  4. pmc From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells
    S Yeh
    George Whipple Laboratory for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and the Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 96:5458-63. 1999
    ..Together, these data provide a novel pathway from HER2/Neu to AR transactivation, and they may represent one of the reasons for the PSA re-elevation and hormone resistance during androgen ablation therapy in prostate cancer patients...
  5. ncbi Change of the cell cycle after flutamide treatment in prostate cancer cells and its molecular mechanism
    Yong Wang
    Department of Urology, Tangdu Hospital, China
    Asian J Androl 7:375-80. 2005
    ..To explore the effect of androgen receptor (AR) on the expression of the cell cycle-related genes, such as CDKN1A and BTG1, in prostate cancer cell line LNCaP...
  6. ncbi Are expression and localization of tight and adherens junction proteins in testes of adult boar affected by foetal and neonatal exposure to flutamide?
    A Hejmej
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Int J Androl 35:340-52. 2012
    Several recent studies have indicated that androgen disruption induced by the administration of anti-androgen flutamide during critical developmental stages results in various reproductive abnormalities, mainly in rodents...
  7. ncbi Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors
    Abolhassan Ahmadiani
    Neuroscience Center, Shaheed Beheshti University of Medical Sciences, Tehran 13164, Iran
    Epilepsia 44:629-35. 2003
    There is some structural similarity between the androgen receptor antagonist, flutamide (Flut) and benzodiazepines (BZDs). We evaluated the possible anticonvulsant effect and interaction of Flut with BZD receptors in common seizure models.
  8. ncbi Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity
    Rohini Kashimshetty
    University of Connecticut School of Pharmacy, Department of Pharmaceutical Sciences, Storrs, CT 06269, USA
    Toxicol Appl Pharmacol 238:150-9. 2009
    b>Flutamide, a widely used nonsteroidal anti-androgen, but not its bioisostere bicalutamide, has been associated with idiosyncratic drug-induced liver injury...
  9. ncbi Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells
    Nicola J Mabjeesh
    Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 9:2416-25. 2003
    ..Experimental Design: Androgen and antiandrogen effects were evaluated on HIF-1alpha protein and HIF-1 transcriptional activation in human PCA cells...
  10. ncbi Lyophilization monophase solution technique for improvement of the physicochemical properties of an anticancer drug, flutamide
    Nazik Elgindy
    Department of Industrial Pharmacy, University of Alexandria, Alexandria, Egypt
    Eur J Pharm Biopharm 74:397-405. 2010
    b>Flutamide (FLT), an anticancer drug for prostatic carcinoma, has poor aqueous solubility and low oral bioavailability...
  11. pmc Effects of long-term flutamide treatment during development in zebra finches
    William Grisham
    Department of Psychology and Laboratory of Neuroendocrinology of Brain Research Institute, University of California, Los Angeles, CA 90095 1563, United States
    Neurosci Lett 418:92-6. 2007
    ..Co-administering flutamide, an androgen receptor blocker, with estrogen impedes estrogen's masculinizing effects on the song system, ..
  12. ncbi Effects of 17beta-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhage
    Frank Hildebrand
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, G094 Volker Hall, 1670 University Boulevard, Birmingham, AL 35294 0019, USA
    Cytokine 36:107-14. 2006
    ..females following trauma-hemorrhage, we hypothesized that administration of the androgen receptor antagonist flutamide at the onset of resuscitation will maintain the immune function of the spleen following trauma-hemorrhage...
  13. ncbi Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate
    Eve Mylchreest
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Reprod Toxicol 16:19-28. 2002
    ..Although similar effects are produced by the potent androgen receptor (AR) antagonist flutamide and are indicative of disruption of male sexual differentiation via an antiandrogenic mechanism, DBP is not an ..
  14. ncbi Flutamide versus prednisone in patients with prostate cancer symptomatically progressing after androgen-ablative therapy: a phase III study of the European organization for research and treatment of cancer genitourinary group
    S D Fossa
    Department of Medical Oncology and Radiotherapy, Norwegian Radium Hospital, Oslo, Norway
    J Clin Oncol 19:62-71. 2001
    ..TTP), overall survival, and quality of life (QL) were compared in patients with hormone-resistant prostate cancer (HRPC) treated with prednisone (5 mg orally, four times a day) or flutamide (250 mg orally, three times a day).
  15. ncbi Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study
    Alessandra Gambineri
    Division of Endocrinology, Department of Internal Medicine, S Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    J Clin Endocrinol Metab 91:3970-80. 2006
    The few controlled trials performed so far indicate that the addition of metformin and/or flutamide to a hypocaloric diet in obese women with polycystic ovary syndrome (PCOS) effectively influences different phenotypic aspects of the ..
  16. ncbi Characterization of responses to the antiandrogen flutamide in a short-term reproduction assay with the fathead minnow
    Kathleen M Jensen
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Boulevard, Duluth, MN 55804 USA
    Aquat Toxicol 70:99-110. 2004
    ..responses of fathead minnow reproductive endocrinology and physiology to the mammalian antiandrogen, flutamide. Male and female fish were exposed to nominal (target) concentrations of 50 and 500 microg flutamide/l for 21-..
  17. ncbi Androgens and postmeiotic germ cells regulate claudin-11 expression in rat Sertoli cells
    Anne Florin
    Institut National de la Sante et de la Recherche Medicale, Unité 407, Faculté de médecine Lyon Sud, BP 12, 69921 Oullins Cedex, France
    Endocrinology 146:1532-40. 2005
    In the present study we investigated whether fetal exposure to flutamide affected messenger and protein levels of claudin-11, a key Sertoli cell factor in the establishment of the hemotesticular barrier, at the time of two key events of ..
  18. ncbi Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites
    Seva E Kostrubsky
    Department of Safety Science and Pharmacokinetics, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    Chem Res Toxicol 20:1503-12. 2007
    Treatment with flutamide has been associated with clinical hepatotoxicty. The toxicity, metabolism,and transport of flutamide were investigated using cultured human hepatocytes...
  19. ncbi Efficacious chemoprevention of primary prostate cancer by flutamide in an autochthonous transgenic model
    S Raghow
    University of Tennessee Urologic Research Laboratories, Memphis 38163, USA
    Cancer Res 60:4093-7. 2000
    ..A pilot study was undertaken to test the efficacy of flutamide (an antiandrogen) in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model of prostate cancer...
  20. ncbi Cytotoxicity of flutamide and 2-hydroxyflutamide and their effects on CYP1A2 mRNA in primary rat hepatocytes
    Hai xue Wang
    Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 20 0032, China
    Acta Pharmacol Sin 23:562-6. 2002
    To compare the cytotoxicity of flutamide and its active metabolite 2-hydroxyflutamide and their effects on cytochrome P-450 1A2 mRNA in primary rat hepatocytes.
  21. ncbi The regulation of HSL and LPL expression by DHT and flutamide in human subcutaneous adipose tissue
    L A Anderson
    Department of Medicine, University of Birmingham, Division of Medical Sciences, Edgbaston, Birmingham, UK
    Diabetes Obes Metab 4:209-13. 2002
    ..subcutaneous adipocytes (Scad) (n = 15) were treated with either DHT (10(-7)-10(-9) m), an antiandrogen, flutamide (FLT: 10(-7)-10(-9) m) or a combination of DHT (10(-7)-10(-9) m) with FLT (10(-8) m)...
  22. ncbi Identification of a novel glutathione conjugate of flutamide in incubations with human liver microsomes
    Ping Kang
    Pharmacokinetics Dynamics and Metabolism, Pfizer Global Research and Development, San Diego, CA 92121, USA
    Drug Metab Dispos 35:1081-8. 2007
    b>Flutamide, a nonsteroidal antiandrogen drug widely used in the treatment of prostate cancer, has been associated with rare incidences of hepatotoxicity in patients...
  23. ncbi The photochemistry of flutamide and its inclusion complex with beta-cyclodextrin. Dramatic effect of the microenvironment on the nature and on the efficiency of the photodegradation pathways
    S Sortino
    Dipartimento di Scienze Chimiche, Universita di Catania, Viale Andrea Doria, 8 I 95125 Catania, Italy
    Photochem Photobiol 73:6-13. 2001
    The photochemistry of the anticancer drug flutamide (FM), 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide, in homogeneous media and in the beta-cyclodextrin (beta-CD) cavity has been investigated...
  24. ncbi An electrochemical evidence of free radicals formation from flutamide and its reactivity with endo/xenobiotics of pharmacological relevance
    L J Nunez-Vergara
    Laboratory of Bioelectrochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago
    Bioelectrochemistry 53:103-10. 2001
    This paper reports the feasibility of free radicals formation from flutamide by using cyclic voltammetry...
  25. ncbi Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1
    Ya Ching Hsieh
    Center for Surgical Research, Univ of Alabama at Birmingham, 1670 Univ Boulevard, Birmingham Alabama 35294 0019, USA
    Am J Physiol Heart Circ Physiol 290:H416-23. 2006
    Although previous studies have shown that flutamide improves cardiovascular function after trauma-hemorrhage, the mechanisms responsible for the salutary effect remain unknown...
  26. ncbi Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in nonobese adolescents and women
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Fertil Steril 86:S24-5. 2006
    Hyperinsulinemic hyperandrogenism is the core of polycystic ovary syndrome (PCOS), and, accordingly, low-dose flutamide-metformin proved so far to be a most effective approach to normalize the broad spectrum of PCOS anomalies in nonobese ..
  27. ncbi Role of enzymatic N-hydroxylation and reduction in flutamide metabolite-induced liver toxicity
    Masato Ohbuchi
    Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba ku, Sendai, 980 8578, Japan
    Drug Metab Dispos 37:97-105. 2009
    b>Flutamide is used for prostate cancer therapy but occasionally induces severe liver injury. Flutamide is hydrolyzed in the body into 5-amino-2-nitrobenzotrifluoride (FLU-1) and then further oxidized...
  28. pmc Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy
    Maria Vinaixa
    Metabolomics Platform of the Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders, Rovira i Virgili University, Tarragona, Spain
    PLoS ONE 6:e29052. 2011
    ..Recently, a new polytherapy consisting of low-dose flutamide, metformin and pioglitazone in combination with an estro-progestagen resulted in the regulation of endocrine ..
  29. ncbi Impaired male sexual development in perinatal Sprague-Dawley and Long-Evans hooded rats exposed in utero and lactationally to p,p'-DDE
    L You
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 45:162-73. 1998
    ....
  30. pmc Prenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophy
    Jamie A Johansen
    Neuroscience Program, Michigan State University, East Lansing, MI 48109, USA
    Neurodegener Dis 8:25-34. 2011
    ..We have previously reported that AR toxicity was ligand dependent in our model, and that very few transgenic (tg) males survived beyond birth...
  31. ncbi Blockade of the in vitro effects of testosterone and erythropoietin on Cfu-E and Bfu-E proliferation by pretreatment of the donor rats with cyproterone and flutamide
    L A Malgor
    Instituto de Investigaciones Biofarmacológicas, Catedra de Farmacologia, Facultad de Medicina, Corrientes, Argentina
    Acta Physiol Pharmacol Ther Latinoam 48:99-105. 1998
    ..marrow cells of donor rats pretreated for 2 days with the androgen antagonists cyproterone (10 mg/kg/day) and flutamide (160 mg/kg/day). Specific nuclear receptors for testosterone were demonstrated in marrow erythroid cells...
  32. ncbi Flutamide, an androgen receptor antagonist, improves heatstroke outcomes in mice
    Chian Yuh Lin
    The Institute of Basic Medical Sciences, National Cheng Kung University School of Medicine, Tainan, Taiwan
    Eur J Pharmacol 688:62-7. 2012
    b>Flutamide has been used as an adjunct for decreasing the mortality from subsequent sepsis. Heatstroke resembles septic shock in many aspects...
  33. ncbi Combination of resveratrol and antiandrogen flutamide has synergistic effect on androgen receptor inhibition in prostate cancer cells
    Li Kai
    Cancer Institute, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, U S A
    Anticancer Res 31:3323-30. 2011
    ..The combination of dietary compound resveratrol with known therapeutic agents, such as the antiandrogen flutamide, may be particularly attractive due to the pharmacological safety of resveratrol.
  34. ncbi Mechanism responsible for the salutary effects of flutamide on cardiac performance after trauma-hemorrhagic shock: Upregulation of cardiomyocyte estrogen receptors
    Huang Ping Yu
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 35294, USA
    Surgery 138:85-92. 2005
    Although flutamide (FTM), an androgen-receptor antagonist, normalizes the depressed immune and cardiac function in males after trauma hemorrhage (T-H), the mechanism responsible for its salutary effects remains unknown...
  35. ncbi Open trial of flutamide for treatment of obsessive-compulsive disorder
    M Altemus
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 60:442-5. 1999
    ..In this study, we examined the effects of treatment with flutamide, a synthetic, nonsteroidal, competitive antagonist of the androgen receptor, on OCD symptoms.
  36. ncbi Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury
    Satonori Higuchi
    Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa 920 1192, Japan
    J Appl Toxicol 32:815-22. 2012
    ..b>Flutamide rarely causes liver dysfunction in humans, and immune allergic reactions have been suggested in some cases...
  37. ncbi Elevated level of 17β-estradiol is associated with overexpression of FSHR, CYP19A1, and CTNNB1 genes in porcine ovarian follicles after prenatal and neonatal flutamide exposure
    M Grzesiak
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Theriogenology 78:2050-60. 2012
    ..In this study, we tested whether prenatal and neonatal exposure to antiandrogen flutamide affected ovarian 17β-estradiol (E(2)) synthesis and the associated gene expression in large antral follicles of ..
  38. ncbi Differential expression of connexin 43 in adult pig testes during normal spermatogenic cycle and after flutamide treatment
    I Kopera
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Reprod Domest Anim 46:1050-60. 2011
    ..asked whether androgen withdrawal caused by prenatal (GD20, GD80) or neonatal (PD2) exposure to an anti-androgen flutamide alters Cx43 gene expression and may induce delayed effects on morphology and function of adult pig testes...
  39. ncbi Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis
    Akinobu Watanabe
    Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Drug Metab Dispos 37:1513-20. 2009
    b>Flutamide, an antiandrogen drug, is widely used for the treatment of prostate cancer. The initial metabolic pathways of flutamide are hydroxylation and hydrolysis...
  40. ncbi Prenatal and neonatal exposure to flutamide affects function of Leydig cells in adult boar
    M Kotula-Balak
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Gronostajowa 9, 30 387 Krakow, Poland
    Domest Anim Endocrinol 42:142-54. 2012
    In this study, flutamide, an androgen receptor antagonist, was used as a tool to better understand the role of androgen receptor signaling and androgen signaling disruption during fetal and neonatal periods on porcine Leydig cell ..
  41. ncbi Lyophilized flutamide dispersions with polyols and amino acids: preparation and in vitro evaluation
    Nazik Elgindy
    Department of Industrial Pharmacy, Faculty of Pharmacy, University of Alexandria, 1 El Khartoum Square, El Azarita, Alexandria, Egypt
    Drug Dev Ind Pharm 37:446-55. 2011
    b>Flutamide (FLT) has poor aqueous solubility and low oral bioavailability.
  42. ncbi Flutamide depresses expression of cortactin in the ectoplasmic specialization between the Sertoli cells and spermatids in the mouse testis
    Reiko Anahara
    Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoku, Chiba 260 8670, Japan
    Food Chem Toxicol 44:1050-6. 2006
    b>Flutamide (FLUT) has potent anti-androgenic activity and is used in the medical field and in a screening test to detect endocrinologically active compounds...
  43. ncbi Quality-adjusted survival (Q-TWiST) analysis of EORTC trial 30853: comparing goserelin acetate and flutamide with bilateral orchiectomy in patients with metastatic prostate cancer. European Organization for Research and Treatment of Cancer
    I Rosendahl
    Data Center, European Organization for Research and Treatment of Cancer, Brussels, Belgium
    Prostate 38:100-9. 1999
    ..However, the MAB treatment arm had a higher frequency of reported side effects...
  44. ncbi Optimization of formulation parameters for the preparation of flutamide liposomes by 3(3) factorial 26-term logit model
    R S R Murthy
    Pharmacy Department, Faculty of Technology and Engineering, MS University of Baroda, Gujarat, India
    Pharm Dev Technol 9:369-77. 2004
    ..PC): cholesterol (Chol) molar ratio (X3) using 3(3) factorial 26-term logit model to maximize the Flutamide absorption at the target site in the treatment of prostatic cancer by maximizing the entrapment of Flutamide (..
  45. ncbi Biopolymeric microparticles combined with lyophilized monophase dispersions for controlled flutamide release
    Nazik Elgindy
    Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, El Khartoum Square, Azarita, Alexandria 21521, Egypt
    Int J Pharm 411:113-20. 2011
    Despite its short half-life, no controlled release formula of flutamide (FLT) was prepared until now...
  46. ncbi Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
    Renato Simões Cordeiro
    Department of Cell Biology, Institute of Biology, UNICAMP, CP 6109, 13084 971, Campinas, SP, Brazil
    Biocell 28:21-30. 2004
    The flutamide antiandrogenic effects on the Guinea pig male prostate morphology in puberal, post-puberal and adult ages were evaluated in the present study...
  47. ncbi Mate calling behavior of male South African clawed frogs (Xenopus laevis) is suppressed by the antiandrogenic endocrine disrupting compound flutamide
    Thomas Behrends
    Institute of Biology, Humboldt University Berlin, Berlin, Germany
    Gen Comp Endocrinol 168:269-74. 2010
    ..Several environmental pollutants have been identified as antiandrogenic endocrine disrupting chemicals (EDC), with flutamide (FLU) being a model compound for this type of action...
  48. ncbi Play, copulation, anatomy, and testosterone in gonadally intact male rats prenatally exposed to flutamide
    Joseph M Casto
    Department of Psychology, Villanova University, Villanova, PA 19085, USA
    Physiol Behav 79:633-41. 2003
    ..copulatory patterns was evaluated in male offspring of rats injected with 5 mg of the androgen receptor blocker flutamide (4'-nitro-3'-trifluoromethylisobutyranilide) from Days 11-21 of pregnancy...
  49. ncbi Suppression of mutant androgen receptors by flutamide
    Junichiro Ishioka
    Department of Urology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Urol 16:516-21. 2009
    To examine the effects of flutamide and hydroxyflutamide on the transactivation of mutant androgen receptors.
  50. ncbi An environmental antiandrogen, vinclozolin, alters the organization of play behavior
    A K Hotchkiss
    Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA
    Physiol Behav 79:151-6. 2003
    ..neonatal male rats were injected from Postnatal Days (PND) 2 to 3 with corn oil, pharmacological antiandrogen flutamide (50 mg/kg/day) or vinclozolin (200 mg/kg/day); whereas neonatal females were treated either with corn oil or ..
  51. ncbi Effects of the antiandrogen flutamide on the expression of protein kinase C isoenzymes in LNCaP and PC3 human prostate cancer cells
    Leire Montalvo
    Departamento de Bioquimica y Biologia Molecular, Universidad de Alcala, E 28871 Alcala de Henares, Spain
    Biosci Rep 24:11-21. 2004
    b>Flutamide is a nonsteroidal antiandrogen that is frequently used for total androgen blockage in the treatment of advanced prostate cancer...
  52. ncbi Clinical efficacy of low dose flutamide plus Diane-35 in the treatment of idiopathic hirsutism and polycystic ovary syndrome
    Abdullah Boztosun
    Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey
    Ginekol Pol 84:258-62. 2013
    ..The aim of this study was to evaluate the efficacy of flutamide plus diane 35 in the treatment of idiopathic hirsutism and polycystic ovary syndrome.
  53. ncbi Flutamide inhibits nifedipine- and interleukin-1 beta-induced collagen overproduction in gingival fibroblasts
    H K Lu
    Periodontal Department, Taipei Medical University College of Oral Medicine, Taipei, Taiwan
    J Periodontal Res 45:451-7. 2010
    To understand the role of the androgen receptor in gingival overgrowth, the effects of flutamide on interleukin-1 beta- and nifedipine-induced gene expression of connective tissue growth factor (CTGF/CCN2) and collagen production in ..
  54. ncbi Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species
    Jessica Amadio
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, University College Dublin, Ardmore House, Dublin 4, Ireland
    Biotechnol Lett 33:321-6. 2011
    ..We report the transformation of the anti-cancer drug flutamide in Cunninghamella sp...
  55. ncbi Exposure of juvenile guppies to three antiandrogens causes demasculinization and a reduced sperm count in adult males
    Mark Bayley
    Department of Zoology, Institute of Biological Sciences, University of Aarhus, Aarhus, Denmark
    Aquat Toxicol 56:227-39. 2002
    ..p,p'-DDE, can function as antiandrogens in mammals in a manner similar to the therapeutic antiandrogen flutamide. In mammals, these chemicals bind the androgen receptor and prevent the transcription of the associated genes ..
  56. ncbi Serum prostate specific antigen levels in women with polycystic ovary syndrome and the effect of flutamide+desogestrel/ethinyl estradiol combination
    M Bahceci
    Department of Endocrinology and Metabolism, Dicle University, School of Medicine, Diyarbakir, Turkey
    J Endocrinol Invest 27:353-6. 2004
    ..We aimed to determine serum PSA level in hirsute women and evaluate the effect of flutamide+desogestrel/ethynil estradiol combination.
  57. ncbi Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist
    M E Taplin
    University of Massachusetts Cancer Center, Worcester 01655, USA
    Cancer Res 59:2511-5. 1999
    ..Mutations were found in 5 of 16 patients who received combined androgen blockade with the AR antagonist flutamide, and these mutant ARs were strongly stimulated by flutamide...
  58. ncbi The mitochondrial-dependent pathway is chronically affected in testicular germ cell death in adult rats exposed in utero to anti-androgens
    A Bozec
    Institut National de la Santé et de la Recherche Médicale INSERM U 407, Faculté de médecine Lyon Sud, BP 12, 69921 Oullins, France
    J Endocrinol 183:79-90. 2004
    ..By using rats exposed in utero to the anti-androgenic compound flutamide (0...
  59. ncbi Adjuvant therapy with flutamide for presurgical volume reduction in juvenile nasopharyngeal angiofibroma
    Alok Thakar
    Department of Otolaryngology and Head Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
    Head Neck 33:1747-53. 2011
    Although 2 studies totaling 11 cases have indicated some benefit of anti-androgen treatment with flutamide on juvenile nasopharyngeal angiofibroma (JNA), it is not part of contemporary practice.
  60. ncbi Novel reagents for the sensitive spectrophotometric determination of flutamide, an anticancer drug in pharmaceutical preparations
    Padmarajaiah Nagaraja
    Department of Studies in Chemistry, University of Mysore, Manasagangotri, 570 006, Mysore, India
    Int J Pharm 235:113-20. 2002
    Simple and sensitive spectrophotometric methods for the determination of flutamide (FLA) in either pure form or in its pharmaceutical preparations are described...
  61. ncbi Combined low-dose flutamide plus finasteride vs low-dose flutamide monotherapy for recurrent prostate cancer: a comparative analysis of two phase II trials with a long-term follow-up
    Lionel L Banez
    Division of Urologic Surgery and the Duke Prostate Center, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    BJU Int 104:310-4. 2009
    To compare the efficacy and tolerability of peripheral androgen blockade using combined low-dose flutamide plus finasteride vs low-dose flutamide monotherapy for treating biochemical relapse after the definitive management of prostate ..
  62. ncbi Suppressive effects of antiandrogens, finasteride and flutamide on development of prostatic lesions in a transgenic rat model
    Y M Cho
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya, Japan
    Prostate Cancer Prostatic Dis 10:378-83. 2007
    ..Finasteride and flutamide were administered to 10-week-old TG rats five times a week for 2, 5 and 7 weeks...
  63. ncbi Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1
    Huang Ping Yu
    University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall, Room G094, Birmingham, AL 35294 0019, USA
    J Leukoc Biol 79:277-84. 2006
    ..Previous studies have also shown that administration of flutamide up-regulated estrogen receptor (ER) expression in males following T-H...
  64. ncbi Flutamide as a preoperative treatment in juvenile angiofibroma (JA) with intracranial invasion: report of 7 cases
    Alberto Labra
    Department of Otolaryngology Head and Neck Surgery, General Hospital of Mexico, Mexico City, Mexico
    Otolaryngol Head Neck Surg 130:466-9. 2004
    To determine the efficacy of flutamide as a tumor reduction factor in patients who have juvenile angiofibroma (JA) with intracranial invasion.
  65. ncbi Metformin versus flutamide in the treatment of metabolic consequences of non-obese young women with polycystic ovary syndrome: a randomized prospective study
    I Sahin
    Department of Endocrinology and Metabolic Diseases, Faculty of Medicine, Inonu University, Malatya, Turkey
    Gynecol Endocrinol 19:115-24. 2004
    ..This study was designed to evaluate the effects of metformin and flutamide on metabolic parameters and insulin resistance in non-obese women with PCOS...
  66. ncbi Neonatal treatment of rats with diethylstilboestrol (DES) induces stromal-epithelial abnormalities of the vas deferens and cauda epididymis in adulthood following delayed basal cell development
    Nina Atanassova
    Institute of Experimental Morphology and Anthropology, Bulgarian Academy of Science, Sofia, Bulgaria
    Reproduction 129:589-601. 2005
    ..However, suppression of testosterone production (GnRH antagonist treatment) or action (flutamide treatment) did not alter basal cell numbers...
  67. ncbi Short-term neoadjuvant androgen deprivation therapy and external-beam radiotherapy for locally advanced prostate cancer: long-term results of RTOG 8610
    Mack Roach
    Department of Radiation Oncology, University of California San Francisco, 1600 Divisadero St, Suite H1031, San Francisco, CA 94143 1708, USA
    J Clin Oncol 26:585-91. 2008
    ..This report summarizes long-term follow-up results...
  68. ncbi Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate
    V D Shultz
    CIIT Centers for Health Research, P.O. Box 12137, Research Triangle Park, NC 27709, USA
    Toxicol Sci 64:233-42. 2001
    ..Pregnant Sprague-Dawley rats received corn oil, DBP (500 mg/kg/day), or flutamide (reference antiandrogen, 50 mg/kg/day) by gavage daily from gestation day (GD) 12 to 21...
  69. ncbi Pioglitazone (7.5 mg/day) added to flutamide-metformin in women with androgen excess: additional increments of visfatin and high molecular weight adiponectin
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Clin Endocrinol (Oxf) 68:317-20. 2008
    Low-dose pioglitazone (Pio), flutamide (Flu), metformin (Met) plus an oestro-progestagen is a novel polytherapy lowering total and visceral adiposity, and reducing carotid intima media thickness (IMT) in hyperinsulinaemic women with ..
  70. pmc Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis
    Wen Hong Kan
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham, G094 Volker Hall, 1670 Univ Blvd, Birmingham, AL 35294 0019, USA
    J Appl Physiol (1985) 105:595-602. 2008
    Although studies have shown that administration of testosterone receptor antagonist, flutamide, following trauma-hemorrhage, improves hepatic, cardiovascular, and immune functions, the precise cellular/molecular mechanisms responsible ..
  71. ncbi Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trial
    J Calaf
    Servicio de Obstetricia y Ginecologia, Hospital de la Santa Creu i Sant Pau, Avenida Sant Antoni M Claret, 167, 08025 Barcelona, Spain
    J Clin Endocrinol Metab 92:3446-52. 2007
    Our objective was to test the efficacy and tolerability of three doses of flutamide (125, 250, and 375 mg) combined with a triphasic oral contraceptive (ethynylestradiol/levonorgestrel) during 12 months to treat moderate to severe ..
  72. ncbi Combined low-dose pioglitazone, flutamide, and metformin for women with androgen excess
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 92:1710-4. 2007
    ..treatments for hyperinsulinemic hyperandrogenism in nonobese women is combined androgen receptor blockade (with flutamide; Flu), insulin sensitization (with metformin; Met) plus an estroprogestagen contraceptive...
  73. ncbi Profiling the hepatic effects of flutamide in rats: a microarray comparison with classical aryl hydrocarbon receptor ligands and atypical CYP1A inducers
    Kevin J Coe
    Department of Medicinal Chemistry, University of Washington, Seattle, WA, USA
    Drug Metab Dispos 34:1266-75. 2006
    The antiandrogen flutamide (FLU) is used primarily for prostate cancer and is an idiosyncratic hepatotoxicant that sometimes causes severe liver problems...
  74. ncbi Flutamide-metformin plus ethinylestradiol-drospirenone for lipolysis and antiatherogenesis in young women with ovarian hyperandrogenism: the key role of early, low-dose flutamide
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 89:4716-20. 2004
    A low-dose combination of flutamide-metformin and ethinylestradiol-drospirenone was recently found to reduce the excess of total and abdominal fat, to diminish the deficit in lean mass, and to attenuate the dysadipocytokinemia of young ..
  75. ncbi Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and/or flutamide markedly reduces final sertoli cell number in the rat
    Sarah A Auharek
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom
    Endocrinology 151:2868-75. 2010
    ..This study addressed these questions and investigated whether continued maternal exposure to DBP or to flutamide from Pnd1-Pnd15 could prevent SC number compensation, because this would have implications for how sperm counts ..
  76. ncbi Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in non-obese adolescents and women
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Hum Reprod Update 12:243-52. 2006
    ..At present, there is no approved therapy for PCOS. Recent studies indicate that a low-dose combination of flutamide (Flu; a generic androgen-receptor blocker) and metformin (Met; a generic insulin-sensitizer) normalizes the ..
  77. ncbi Flutamide-metformin plus an oral contraceptive (OC) for young women with polycystic ovary syndrome: switch from third- to fourth-generation OC reduces body adiposity
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Spain
    Hum Reprod 19:1725-7. 2004
    Low-dose flutamide-metformin has been developed as a background therapy for non-obese adolescents and young women with hyperinsulinaemic hyperandrogenism, a variant of polycystic ovary syndrome (PCOS)...
  78. ncbi Flutamide-metformin therapy to reduce fat mass in hyperinsulinemic ovarian hyperandrogenism: effects in adolescents and in women on third-generation oral contraception
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain
    J Clin Endocrinol Metab 88:4720-4. 2003
    ..The combination of flutamide (125-250 mg/d) and metformin has additive benefits on endocrine- metabolic indices in women with polycystic ..
  79. ncbi Comparison of anti-androgenic activity of flutamide, vinclozolin, procymidone, linuron, and p, p'-DDE in rodent 10-day Hershberger assay
    Il Hyun Kang
    Endocrine Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun dong, Eunpyung Ku, Seoul 122 704, South Korea
    Toxicology 199:145-59. 2004
    ..The aim of this study was to compare the anti-androgenic properties of flutamide, vinclozolin, procymidone, linuron, and p,p'-DDE in a 10-day Hershberger assay...
  80. ncbi Low-dose flutamide-metformin therapy reverses insulin resistance and reduces fat mass in nonobese adolescents with ovarian hyperandrogenism
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona 08950, Spain
    J Clin Endocrinol Metab 88:2600-6. 2003
    ..Combined antiandrogen (flutamide 250 mg/d) and insulin-sensitizing (metformin) therapy has beneficial effects, in particular on dyslipidemia and ..
  81. ncbi Absence of hepatotoxicity after long-term, low-dose flutamide in hyperandrogenic girls and young women
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Hum Reprod 20:1833-6. 2005
    b>Flutamide is a pure non-steroidal anti-androgen that may be hepatotoxic, when given in high-dose (750 mg/d). Low- to ultralow-doses (250-62...
  82. ncbi Inhibition of androgen receptor and Cdc25A phosphatase as a combination targeted therapy in molecular apocrine breast cancer
    Ali Naderi
    The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    Cancer Lett 298:74-87. 2010
    ..ERK phosphorylation using a Cdc25A phosphatase inhibitor, PM-20 in combination with AR inhibition using flutamide in this subtype...
  83. ncbi Low-dose pioglitazone, flutamide, metformin plus an estro-progestagen for non-obese young women with polycystic ovary syndrome: increasing efficacy and persistent safety over 30 months
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Gynecol Endocrinol 26:869-73. 2010
    ..4 year; BMI: 23.7 kg/m(2)) received metformin (850 mg/day), flutamide (62.5 mg/day), pioglitazone (7...
  84. ncbi The model anti-androgen flutamide suppresses the expression of typical male stickleback reproductive behaviour
    Marion Sebire
    CEFAS Weymouth Laboratory, Environment and Animal Health, Barrack Road, The Nothe, Weymouth, Dorset DT4 8UB, UK
    Aquat Toxicol 90:37-47. 2008
    ..quiescent male sticklebacks that were simultaneously exposed for a 21-day period to the mammalian anti-androgen flutamide (FL) at 100, 500 and 1000 microg/l (plus a water control)...
  85. ncbi Ethinylestradiol-drospirenone, flutamide-metformin, or both for adolescents and women with hyperinsulinemic hyperandrogenism: opposite effects on adipocytokines and body adiposity
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Déu L I, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 89:1592-7. 2004
    ..We studied the effects of two new treatment options, ethinylestradiol-drospirenone and flutamide-metformin, and of their combination on adipocytokinemia and body adiposity in adolescents and women with PCOS...
  86. ncbi Low-dose combination of flutamide, metformin and an oral contraceptive for non-obese, young women with polycystic ovary syndrome
    Lourdes Ibanez
    Hospital Sant Joan de Deu, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    Hum Reprod 18:57-60. 2003
    ..young women with polycystic ovary syndrome (PCOS) is normalized more effectively by combined treatment with flutamide and metformin than by either of these drugs in monotherapy...
  87. ncbi Clinical outcome of maximum androgen blockade using flutamide as second-line hormonal therapy for hormone-refractory prostate cancer
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan
    BJU Int 96:791-5. 2005
    To investigate the efficacy of maximum androgen blockade (MAB) using flutamide as second-line hormonal therapy for advanced hormone-refractory prostate cancer (HRPC).
  88. ncbi Treatment of hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism in nonobese, adolescent girls: effect of flutamide
    L Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Spain
    J Clin Endocrinol Metab 85:3251-5. 2000
    ..b>Flutamide, a nonsteroidal antiandrogen, is known to be effective in reducing hirsutism in patients with ovarian ..
  89. ncbi High neutrophil count in girls and women with hyperinsulinaemic hyperandrogenism: normalization with metformin and flutamide overcomes the aggravation by oral contraception
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Spain
    Hum Reprod 20:2457-62. 2005
    ..The endocrine hallmark of polycystic ovary syndrome (PCOS) is hyperinsulinaemic hyperandrogenism; another facet of PCOS is low-grade inflammation...
  90. ncbi Connexin 43 gene expression in male and female gonads of porcine offspring following in utero exposure to an anti-androgen, flutamide
    Malgorzata Durlej
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Acta Histochem 113:6-12. 2011
    The aim of this study was to show the effect of maternal exposure to flutamide on connexin 43 (Cx43) gene expression in testes and ovaries of 2-day-old piglets...
  91. ncbi Effects of flutamide in the rat testis on the expression of occludin, an integral member of the tight junctions
    Myung Chan Gye
    Department of Life Science, College of Natural Sciences, Hanyang University, 133 791, Seoul, South Korea
    Toxicol Lett 143:217-22. 2003
    In an effort to uncover the gonadal impairment by the antiandrogen flutamide (FM) in males, the effect of subacute administration of FM on the expression of tight junction (TJ) genes that build the blood-testis barrier (BTB) was ..
  92. ncbi Flutamide-metformin plus ethinylestradiol-drospirenone for lipolysis and antiatherogenesis in young women with ovarian hyperandrogenism: the key role of metformin at the start and after more than one year of therapy
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 90:39-43. 2005
    b>Flutamide (Flu)-metformin (Met) with ethinylestradiol-drospirenone is a combination therapy that reduces the total and abdominal fat excess, diminishes the lean mass deficit, and attenuates the dysadipocytokinemia of young and nonobese ..
  93. pmc Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening
    Kevin J Coe
    Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA
    Chem Res Toxicol 20:1277-90. 2007
    b>Flutamide (FLU) is an antiandrogen primarily used in the treatment of metastatic prostate cancer. It is an idiosyncratic hepatotoxicant that sometimes results in severe liver toxicity...
  94. ncbi Saccharomyces cerevisiae intervention for relieving flutamide-induced hepatotoxicity in male rats
    F Mannaa
    Medical Physiology Department, National Research Centre, Dokki, Giza, Egypt
    Pharmazie 60:689-95. 2005
    ..the protective role of baker's yeast Saccharomyces cerevisiae against the hepatotoxic effect of the drug flutamide that is widely used for treatment of metastatic prostate adenocarcinoma...
  95. ncbi Androgen-dependent mechanisms of Wolffian duct development and their perturbation by flutamide
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    Endocrinology 147:4820-30. 2006
    ..The present study used in utero exposure of pregnant rats to the androgen receptor antagonist flutamide (50 or 100 mg/kg) to explore possible mechanisms. Pregnant rats were treated from embryonic d 15.5 (E15...
  96. ncbi Androgen receptor antagonism by the organophosphate insecticide fenitrothion
    H Tamura
    Department of Applied Biochemistry, Meijo University, Nagoya 468-8502, Japan
    Toxicol Sci 60:56-62. 2001
    ..An additional group of rats was given testosterone propionate and flutamide (50 mg/kg/day). Motor activity and acetylcholinesterase activity in whole blood and brain were also assessed...
  97. ncbi Endocrine active agents: implications of adverse and non-adverse changes
    Paul M D Foster
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Pathol 30:59-65. 2002
    ....
  98. ncbi Inhibition of PSA flare in prostate cancer patients by administration of flutamide for 2 weeks before initiation of treatment with slow-releasing LH-RH agonist
    K Noguchi
    Department of Urology, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Int J Clin Oncol 6:29-33. 2001
    A prospective randomized study was designed to determine whether flutamide (FLU) administered before treatment with a luteinizing hormone-releasing hormone agonist (LH-RHa) prevented prostate-specific antigen (PSA) flare in prostate ..
  99. ncbi Anti-progestogenic effect of flutamide on uterine expression of calbindin-D9k mRNA and protein in immature mice
    Youn Kyu Ji
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
    Reprod Toxicol 22:694-701. 2006
    ..The induction of CaBP-9k can be employed as a biomarker for steroidal substrates as endocrine disruptors (EDs). Flutamide (FLU) is a non-steroidal anti-androgen or pro-drug that is rapidly metabolized to hydroxyflutamide, which may ..
  100. ncbi Testosterone antagonist (flutamide) blocks ovulation and preovulatory surges of progesterone, luteinizing hormone and oestradiol in laying hens
    P L Rangel
    Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, Cd Universitaria
    Reproduction 131:1109-14. 2006
    ..Groups of laying hens (n = 10-22) were treated with the androgen receptor antagonist, flutamide, at 8 h intervals for 24 h at doses of 0, 31.25, 62.5, 125 and 250 mg. All doses reduced egg laying (P < 0...
  101. ncbi Discontinuous low-dose flutamide-metformin plus an oral or a transdermal contraceptive in patients with hyperinsulinaemic hyperandrogenism: normalizing effects on CRP, TNF-alpha and the neutrophil/lymphocyte ratio
    Lourdes Ibanez
    Endocrinology Unit and Hormonal Laboratory, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Hum Reprod 21:451-6. 2006
    Low-dose flutamide-metformin (Flu-Met) with an oral contraceptive is a therapeutic option for women with hyperinsulinaemic hyperandrogenism...

Research Grants62

  1. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
    ..However, the systemic antiandrogen side effects of marketed nonsteroidal androgen antagonists (flutamide, nilutamide, bicalutamide) and 5[unreadable]-reductase type 2 inhibitors (finasteride) are serious drawbacks to ..
  2. Aryl Hydrocarbon Receptor Modulators for the Treatment of Hepatocellular Carcinom
    Siva Kumar Kolluri; Fiscal Year: 2012
    ..already resulted in the identification of some compounds of interest including the clinically used antiandrogen flutamide that promoted transcriptional activation of AhR, induction of AhR- regulated target genes and AhR-dependent ..
  3. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad H Chaudry; Fiscal Year: 2010
    ..findings that 17p-estradiol (E2) has the unique ability to protect immune cell responses following T-H, and that flutamide [androgen receptor (AR) antagonist] also utilizes E2-mediated pathway in restoring immune functions in males, ..
  4. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad H Chaudry; Fiscal Year: 2012
    ..Furthermore, administration of AR antagonist flutamide in males after T-H normalized cardiac E2 levels, ER levels, mitochondrial ATP levels, and cardiac functions...
  5. Developmental programming: influence of sex steroids and mechanisms
    Chandrasekhar Yallampalli; Fiscal Year: 2013
    ..the onset and severity of hypertension, and these changes are reversed by respective steroid replacement and flutamide. Growth rate, adiposity, and changes in MAP and plasma T and E2 will be assessed...
  6. A Novel Synthetic Androgen Receptor Antagonist
    Zhongyun Dong; Fiscal Year: 2012
    ..prostate cancer cell lines tested, including androgen-independent cells and cells resistant to antiandrogens, flutamide (Flut) or nilutamide (Nilut)...
  7. Mechanism of Estrogen-Induced Penile Dysfunction and Loss of Fertility
    HARI OM GOYAL; Fiscal Year: 2013
    ..Specific aim 3 will test the hypothesis that exposure to anti-androgens (GnRH-antagonist and flutamide) up-regulates ER1 expression because of lower androgenic action, but may not alter PPAR3, C/EBP1, 1 actin, and ..
  8. Metabolic Syndrome in PCOS: Precursors and Interventions
    Andrea Dunaif; Fiscal Year: 2010
    ..We will determine whether the androgen receptor antagonist flutamide, the insulin sensitizing agent metformin or a combination of these medications reduces visceral adiposity, ..
  9. Progesterone control of diurnal GnRH pulses in puberty: impact of androgen excess
    Ruchi Bhabhra; Fiscal Year: 2013
    ..is impaired in the presence of hyperandrogenemia (HA) in adult women and can be restored by the antiandrogen Flutamide. Of interest, testosterone (T) levels progressively increase from early to late puberty in normal girls, which ..
  10. Ack1: A Critical Regulator of Hormone-Refractory Prostate Cancer
    Nupam P Mahajan; Fiscal Year: 2013
    ..g. bicalutamide/casodex and flutamide. However, a small molecule inhibitor of Ack1, 4-Amino-5,6- biaryl-furo[2,3-d]pyrimidine (YL3-026) not only ..
  11. STEROID HORMONES AND NEURONAL REGENERATION
    Kathryn Jones; Fiscal Year: 2001
    ..Two series of experiments will be done. The effects of high doses of E in the presence of the anti-androgen, flutamide, and high versus low doses of E on the rate of regeneration will be determined...
  12. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2005
    ..Some groups will also receive treatment with testosterone, flutamide, an androgen receptor blocker, or finasteride, which blocks conversion of testosterone to dihydrotestosterone...
  13. PATTERNS OF BEHAVIORAL AND HORMONAL DEVELOPMENT
    STEPHEN GLICKMAN; Fiscal Year: 2006
    ..involving both Nissl stains and ICC for various neuropeptides, will examine fetal and adult tissues from the hyena CNS, including tissues derived from mature hyenas that were exposed to flutamide/finasteride in utero.
  14. Efficacy and Mechanism of Novel Androgen Receptor Inhibitors
    Marc I Diamond; Fiscal Year: 2010
    ..compounds function as non-competitive antagonists, and synergize with classical anti-androgens such as hydroxy-flutamide or bicalutamide...
  15. ANDROGEN BIOLOGY TO FETAL LUNG DEVELOPMENT
    John Torday; Fiscal Year: 1999
    ..The anti-androgenic effects of these progestins will be compared with the potent anti-androgen Flutamide, which effectively reverses the androgen inhibition of glucocorticoid-stimulated surfactant production...
  16. Fetal Basis of Sexual Dysfunction: Brain Differentiation
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..animals will be compared with animals treated with the well characterized androgen receptor antagonist flutamide to test the hypotheses that alterations in the GnRH neuronal system and alterations in the chemoarchitecture of ..
  17. MALE PSEUDOHERMAPHRODITISM--THE BIOLOGY OF ANDROGENS
    Julianne Imperato McGinley; Fiscal Year: 1992
    ..Comparison studies will be carried out with the antiandrogen, flutamide, which blocks the action of both T and DHT...
  18. CHARACTERIZATION OF AN INVASIVE HUMAN PROSTATE CANCER
    Haiyen Zhau; Fiscal Year: 2004
    It is proposed to characterize an invasive androgen-repressed and flutamide-stimulated phenotype in an ARCaP model of human prostate cancer metastasis...
  19. Androgen Hormones in PMDD
    Margaret Altemus; Fiscal Year: 2007
    ..The efficacy of a specific androgen receptor antagonist, flutamide, for treatment of PMDD will be tested in a placebo-controlled study...
  20. Application of Metabonomics in Predictive Toxicology
    Sidney Nelson; Fiscal Year: 2009
    ..to a regioisomer that causes intrinsic hepatocellular injury, and 3) of the nitroaromafic anti-androgen drug, flutamide, an idiosyncratic hepatotoxicant, to its less toxic cyano analogue...
  21. Androgen-Independent Prostate Cancer: Mechanisms & Treat
    David Feldman; Fiscal Year: 2004
    ..these cells have promiscuous ARs that are androgen-responsive but not dependent on androgens since flutamide and other steroids can stimulate their growth. The grant has 3 Specific Aims...
  22. PATHOGENESIS OF PHTHALATE-INDUCED REPRODUCTIVE LESIONS
    NORMAN BARLOW; Fiscal Year: 2002
    ..currently unknown, is likely mediated via a pathway different from that of other classic antiandrogens such as flutamide. The developing male fetus is very sensitive to alterations in androgen levels and even a slight perturbation by ..
  23. MECHANISMS SUBSERVING OPIATERGIC CONTROL OF PUBERTY
    JAMES KERRIGAN; Fiscal Year: 1992
    ..receptor blockade on gonadotropin release in normal pubertal boys during the administration of an anti-androgen (flutamide). II...
  24. AR-ASSOCIATED PROTEINS IN PROSTATE CARCINOGENESIS
    Chawnshang Chang; Fiscal Year: 2001
    ..A similar situation might account for the "Flutamide Withdrawal Syndrome" in CaP patients...
  25. Prenatal development, spatial ability, and hippocampus
    Rebecca Herman; Fiscal Year: 2004
    ..abstract_text> ..
  26. Rhesus Embryonic Stem Cell-Derived Serotonin Neurons
    CYNTHIA BETHEA; Fiscal Year: 2007
    ..The knowledge obtained from this work will lead to novel treatments for psychoneuropathologies. [unreadable] [unreadable]..
  27. HORMONAL CONTROL OF THE FEMALE REPRODUCTIVE TRACT
    Robert Brenner; Fiscal Year: 2004
    ..The VEGF family and MMPs during menstrual induction. 2. VEFG-HGF interactions in MMP regulation. 3. KGF-VEGF interactions in spiral artery growth. 4. HGF and VEGF antagonists during menstruation. ..
  28. Novel Active Repressor Model of Human LDL-Receptor Regulation
    Johannes Veldhuis; Fiscal Year: 2008
    ..This would represent a new treatment approach for patients with atherosclerotic disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  29. Maintainance of Organ Function Following Injury
    Irshad Chaudry; Fiscal Year: 2008
    ..Alternatively, administration of flutamide, an androgen antagonist (AA), after hemorrhage-resuscitation in non-castrated rats improves the depressed ..
  30. Analytical Reconstruction of Feedback Signaling in Aging Men
    Johannes Veldhuis; Fiscal Year: 2008
    ..The present proposal develops a general biomathematical framework for dissecting otherwise observed pathways that control hormone output in aging, stress and disease. [unreadable] [unreadable] [unreadable]..
  31. Androgens and Hypothalamic Sensitivity to Progesterone Feedback in Female Puberty
    Susan Blank; Fiscal Year: 2008
    ..Treatment with the androgen receptor blocker flutamide restores hypothalamic sensitivity to P in women with PCOS, indicating that androgens mediate hypothalamic P ..
  32. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  33. ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLES
    Johannes Veldhuis; Fiscal Year: 2005
    ..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
  34. Mechanistic bases for age-related androgen deficiency
    Johannes Veldhuis; Fiscal Year: 2007
    ..Knowing why testosterone falls should help foster new and safer ways to prevent the problem. [unreadable] [unreadable] [unreadable]..
  35. Ensemble Disruption of the GnRH-LH-Testosterone Axis
    Johannes Veldhuis; Fiscal Year: 2007
    ..Expected corollary outcomes are enhanced diagnosis, assessment and management of more subtle pathophysiology of the male gonadal axis in puberty and adulthood. ..
  36. Effects of Male Vocalizations on Long-Term Pair Bonds
    Michelle Tomaszycki; Fiscal Year: 2004
    ..These findings will contribute to an understanding of the importance of vocal communication in the formation and maintenance of social relationships in animals. ..
  37. THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN
    Johannes Veldhuis; Fiscal Year: 2005
    ..An enhanced knowledge base should aid ultimately in formulating more innovative preventive and interventional strategies to limit hyposomatotropism in older and/or estrogen-deficient humans. ..
  38. ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXIS
    Johannes Veldhuis; Fiscal Year: 2005
    ....
  39. Xenogen IVIS-200 Bioluminescent Imaging System
    Alan Pollack; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  40. Gender and susceptibility to kidney damage in high BP
    Jane F Reckelhoff; Fiscal Year: 2010
    ....
  41. Group and Individual Differences in Audition
    Dennis McFadden; Fiscal Year: 2010
    ..If so, theory, diagnosis, treatment, and nosology for ADHD could be affected. ..
  42. Cognitive Effects of Opioids in Older Adults
    Monique Cherrier; Fiscal Year: 2006
    ..abstract_text> ..
  43. BEHAVIORAL DEVELOPMENT--PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 2002
    ..Prenatal androgen exposure was reduced by twice daily administration of flutamide, an androgen receptor blocker. Weekly injections of testosterone enanthate were used to increase androgen...
  44. HETEROSPECIFIC CELL/CELL INTERACTIONS IN PROSTATE GROWTH
    Gerald Cunha; Fiscal Year: 2001
    ..Concepts derived from the analysis of basic cellular mechanisms of prostatic growth will be applied to the pathogenesis of BPH. ..
  45. PHASE I TRIAL OF A PEPTIDE VACCINE AGAINST EGFRVIII
    Bruce Montgomery; Fiscal Year: 2005
    ..To characterize effects of human anti-EGFRvIII antibodies on EGFRvIII signaling. 4. To determine the level of EGFR specific T cell response after immunization with EGFRvIII peptide. ..
  46. SMOOTH MUSCLE-EPITHELIAL INTERACTIONS IN PROSTATE CANCER
    Gerald Cunha; Fiscal Year: 2001
    ..In addition, it is possible that this study will identify one or more strategies for regulating the growth, differentiation and)'or invasive behavior of prostatic carcinoma cells. ..
  47. CELL CELL INTERACTIONS IN PROSTATE CANCER
    Gerald Cunha; Fiscal Year: 2001
    ..These studies should define critical cellular and molecular pathways in both normal and tumorigenic growth of the prostate, and should provide the biological basis of new therapeutic strategies. ..
  48. Role of BAF57 in AR control and prostate cancer growth
    Karen E Knudsen; Fiscal Year: 2010
    ..Together, these studies will reveal the efficacy of BAF57 as a therapeutic target in both early and late stage prostate cancer. ..
  49. Development of Oral Suberoylanilide Hydroxamic Acid
    William Kelly; Fiscal Year: 2003
    ..e.p21WAF1) in tumors. Subsequently, these findings will be correlated with the clinical outcomes. ..
  50. Female sexuality: modulation by estrogen and androgen
    Kim Wallen; Fiscal Year: 2005
    ..sexual initiation in a social group context during normal cycles treated with an androgen receptor blocker (flutamide) or an estrogen receptor blocker (tamoxifen)...
  51. Effect of Continuous vs. Sequential Oral Contraception
    RICHARD LEGRO; Fiscal Year: 2004
    ..Therefore, the risks and benefits of a CCOCP regimen are an important women's health issue that warrant investigation. ..
  52. Androgens and apoE4 induced cognitive impairments
    Jacob Raber; Fiscal Year: 2005
    ....
  53. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  54. Neurotrophins and Tyrosine Kinases in Prostate Cancer
    Christopher Evans; Fiscal Year: 2006
    ..This proposal is based on significant preliminary data and has strong translational potential for future proposals. ..
  55. Orphanin FQ/Nociceptin regulates LH release
    CHAD FORADORI; Fiscal Year: 2006
    ..Overall these studies will provide important information about the mechanisms regulating GnRH neuronal activity and the corresponding release of LH. ..
  56. Steroid influences on brain maturation
    JULIA ZEHR; Fiscal Year: 2006
    ..A basic understanding of the processes controlling pubertal brain development provides a timely foundation for future studies of self-administered steroids, disease states, or environmental endocrine disrupters. ..
  57. Bis-phenol A: Signaling and Mitogenesis in the Prostate
    Karen Knudsen; Fiscal Year: 2006
    ..abstract_text> ..
  58. Photoperiod, melatonin, and reproductive aging
    NED PLACE; Fiscal Year: 2008
    ..Once the objectives of this award have been met, the candidate will work as an independent investigator, and carry out research on reproductive aging that is truly integrative. ..
  59. Testosterone Supplementation in Men with MCI
    Monique Cherrier; Fiscal Year: 2009
    ..Further, results of this study will provide valuable information for planning, larger future trials of T supplementation or selective androgen receptor modulators (SARMs). ..
  60. NEURAL AND BEHAVIORAL ACTIONS OF ANABOLIC STEROIDS
    Ann Clark; Fiscal Year: 2003
    ....