carboxin

Summary

Summary: A systemic agricultural fungicide and seed treatment agent.

Top Publications

  1. ncbi A single amino-acid change in the iron-sulphur protein subunit of succinate dehydrogenase confers resistance to carboxin in Ustilago maydis
    P L Broomfield
    Department of Agricultural Sciences, University of Bristol, UK
    Curr Genet 22:117-21. 1992
  2. ncbi Carboxin resistance transformation of the homobasidiomycete fungus Pleurotus ostreatus
    Y Honda
    Wood Research Institute, Kyoto University, Gokasho Uji, Japan
    Curr Genet 37:209-12. 2000
  3. pmc Structure of Escherichia coli succinate:quinone oxidoreductase with an occupied and empty quinone-binding site
    Jonathan Ruprecht
    Membrane Protein Crystallography Group, Molecular Biosciences Division, Imperial College, London SW72AZ, United Kingdom
    J Biol Chem 284:29836-46. 2009
  4. ncbi Investigating dominant selection markers for Coprinopsis cinerea: a carboxin resistance system and re-evaluation of hygromycin and phleomycin resistance vectors
    Sreedhar Kilaru
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol, BS8 1UG, UK
    Curr Genet 55:543-50. 2009
  5. ncbi A single amino-acid substitution in the iron-sulphur protein subunit of succinate dehydrogenase determines resistance to carboxin in Mycosphaerella graminicola
    W Skinner
    Department of Cell Biology, IACR Long Ashton Research Station, University of Bristol, Long Ashton, Bristol BS18 9AF, UK
    Curr Genet 34:393-8. 1998
  6. doi Molecular characterization of boscalid resistance in field isolates of Botrytis cinerea from apple
    Y N Yin
    Department of Plant Pathology, Washington State University, Tree Fruit Research and Extension Center, Wenatchee, WA 98801, USA
    Phytopathology 101:986-95. 2011
  7. ncbi Flutolanil and carboxin resistance in Coprinus cinereus conferred by a mutation in the cytochrome b560 subunit of succinate dehydrogenase complex (Complex II)
    Y Ito
    Biological Function Division, National Food Research Institute, 305 8642 Tsukuba, Ibaraki, Japan
    Mol Genet Genomics 272:328-35. 2004
  8. doi Identification of three mutant loci conferring carboxin-resistance and development of a novel transformation system in Aspergillus oryzae
    Yoko Shima
    National Food Research Institute, National Agriculture and Food Research Organization NARO, 2 1 12 Kannondai, Tsukuba, Ibaraki 305 8642, Japan
    Fungal Genet Biol 46:67-76. 2009
  9. ncbi Isolation, characterization and sequence of a gene conferring resistance to the systemic fungicide carboxin from the maize smut pathogen, Ustilago maydis
    J P Keon
    Department of Agricultural Sciences, University of Bristol, UK
    Curr Genet 19:475-81. 1991
  10. pmc Pesticide flow analysis to assess human exposure in greenhouse flower production in Colombia
    Camilo Lesmes-Fabian
    Department of Geography, Ludwig Maximilian University of Munich, Luisenstrasse 37 D 80333, Munich, Germany
    Int J Environ Res Public Health 10:1168-85. 2013

Research Grants

Scientific Experts

  • M Henselová
  • Camilo Lesmes-Fabian
  • Joshua G Schier
  • N C Glynn
  • H F Avenot
  • Akinori Ando
  • Lars Hederstedt
  • Maria R Iesce
  • J H Ahtiainen
  • T Joseph-Horne
  • H A Hasan
  • H G Hahn
  • Judith Bowler
  • Yasuhiro Ito
  • R W Buckheit
  • JAMES SIEDOW
  • Yoko Shima
  • Sreedhar Kilaru
  • Gary D Foster
  • Andy M Bailey
  • J Balzarini
  • Paulo Roger L Alves
  • Jun Wei Xu
  • Tomer M Salame
  • Gabriel Scalliet
  • Zhibing Wu
  • Sanae Kano
  • Bart A Fraaije
  • Alma Djulic
  • Y N Yin
  • David Obermayer
  • Kimiko Yabe
  • Hidemi Hatabayashi
  • Susann Milenkovski
  • Amanda J Hartley
  • Chrisse Ngari
  • Jonathan Ruprecht
  • Ana S M B Costa
  • Catherine M Collins
  • M Matsson
  • Willem G van Herk
  • H Kurzawińska
  • Gulmira Sarijeva
  • Li Shar Huang
  • Jong H Kim
  • M Sajid Aqeel Ahmad
  • R Ortiz-Alvarado
  • Takahisa Tsukihara
  • J Hysek
  • María C Carpinella
  • Yoichi Honda
  • Takashi Watanabe
  • Marina Dellagreca
  • Ana Juan-García
  • Tore Brinck
  • Toshikazu Irie
  • Yanshen Deng
  • Toshiaki Miki
  • Christopher N Topp
  • James A Fraser
  • Amarildo Pasini
  • E De Clercq
  • Elke J B N Cardoso
  • Alexandre M Martines
  • José Paulo Sousa
  • Deyu Hu
  • Jian Jiang Zhong
  • Andreas Verras
  • Dana Tal
  • Carlos Bayon
  • Hua Cai
  • Keith Ward
  • Torsten Luksch
  • Michael Niklaus
  • Yitzhak Hadar
  • Diana Steinhauer
  • Jiqing Kuang
  • Raymonde Fonne-Pfister
  • Doriv Knop
  • Michael Csukai
  • Oded Yarden
  • Lucy Kirchhofer-Allan
  • Wei Xue
  • Yi Ning Xu
  • Shixi Wu
  • Sarah Atkins
  • Tsutomu Morinaga
  • R M Esnouf
  • John A Lucas
  • Antoine Daina

Detail Information

Publications74

  1. ncbi A single amino-acid change in the iron-sulphur protein subunit of succinate dehydrogenase confers resistance to carboxin in Ustilago maydis
    P L Broomfield
    Department of Agricultural Sciences, University of Bristol, UK
    Curr Genet 22:117-21. 1992
    ..Ip) subunit of succinate dehydrogenase (Sdh) was determined following PCR amplification of genomic DNA from a carboxin (Cbx)-sensitive Ustilago maydis strain...
  2. ncbi Carboxin resistance transformation of the homobasidiomycete fungus Pleurotus ostreatus
    Y Honda
    Wood Research Institute, Kyoto University, Gokasho Uji, Japan
    Curr Genet 37:209-12. 2000
    ..Ip subunit with an amino-acid substitution (His239 to Leu) and confers resistance to the systemic fungicide, carboxin. The DNA sequence was integrated ectopically in the chromosome of the transformants...
  3. pmc Structure of Escherichia coli succinate:quinone oxidoreductase with an occupied and empty quinone-binding site
    Jonathan Ruprecht
    Membrane Protein Crystallography Group, Molecular Biosciences Division, Imperial College, London SW72AZ, United Kingdom
    J Biol Chem 284:29836-46. 2009
    ..One with the specific quinone-binding site (Q-site) inhibitor carboxin present has been solved at 2.4 A resolution and reveals how carboxin inhibits the Q-site...
  4. ncbi Investigating dominant selection markers for Coprinopsis cinerea: a carboxin resistance system and re-evaluation of hygromycin and phleomycin resistance vectors
    Sreedhar Kilaru
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol, BS8 1UG, UK
    Curr Genet 55:543-50. 2009
    ..A carboxin resistance allele of the Coprinopsis cinerea sdi1 gene, encoding the iron-sulphur protein subunit of succinate ..
  5. ncbi A single amino-acid substitution in the iron-sulphur protein subunit of succinate dehydrogenase determines resistance to carboxin in Mycosphaerella graminicola
    W Skinner
    Department of Cell Biology, IACR Long Ashton Research Station, University of Bristol, Long Ashton, Bristol BS18 9AF, UK
    Curr Genet 34:393-8. 1998
    ..Mutants resistant to the fungicide carboxin (Cbx), a known inhibitor of Sdh, were found to contain a single amino-acid substitution in the third cysteine-..
  6. doi Molecular characterization of boscalid resistance in field isolates of Botrytis cinerea from apple
    Y N Yin
    Department of Plant Pathology, Washington State University, Tree Fruit Research and Extension Center, Wenatchee, WA 98801, USA
    Phytopathology 101:986-95. 2011
    ..There was cross resistance between boscalid and carboxin. Analysis of partial sequences of the iron-sulfur subunit of succinate dehydrogenase gene in B...
  7. ncbi Flutolanil and carboxin resistance in Coprinus cinereus conferred by a mutation in the cytochrome b560 subunit of succinate dehydrogenase complex (Complex II)
    Y Ito
    Biological Function Division, National Food Research Institute, 305 8642 Tsukuba, Ibaraki, Japan
    Mol Genet Genomics 272:328-35. 2004
    ..This sdhC mutation also conferred cross-resistance against another systemic fungicide, carboxin, an anilide that is structurally related to flutolanil...
  8. doi Identification of three mutant loci conferring carboxin-resistance and development of a novel transformation system in Aspergillus oryzae
    Yoko Shima
    National Food Research Institute, National Agriculture and Food Research Organization NARO, 2 1 12 Kannondai, Tsukuba, Ibaraki 305 8642, Japan
    Fungal Genet Biol 46:67-76. 2009
    Mutants exhibiting resistance to the fungicide, carboxin, were isolated from Aspergillus oryzae, and the mutations in the three gene loci, which encode succinate dehydrogenase (SDH) B, C, and D subunits, were identified to be ..
  9. ncbi Isolation, characterization and sequence of a gene conferring resistance to the systemic fungicide carboxin from the maize smut pathogen, Ustilago maydis
    J P Keon
    Department of Agricultural Sciences, University of Bristol, UK
    Curr Genet 19:475-81. 1991
    A gene which confers resistance to the systemic fungicide carboxin (Cbx) has been isolated from the maize pathogen, Ustilago maydis, by transferring a plasmid gene library from a Cbx-resistant mutant strain into a sensitive strain and ..
  10. pmc Pesticide flow analysis to assess human exposure in greenhouse flower production in Colombia
    Camilo Lesmes-Fabian
    Department of Geography, Ludwig Maximilian University of Munich, Luisenstrasse 37 D 80333, Munich, Germany
    Int J Environ Res Public Health 10:1168-85. 2013
    ..applied to estimate the exposure to pesticides such as mancozeb, carbendazim, propamocarb hydrochloride, fosetyl, carboxin, thiram, dimethomorph and mandipropamide...
  11. ncbi Evaluation of solid-phase extraction and stir-bar sorptive extraction for the determination of fungicide residues at low-microg kg(-1) levels in grapes by liquid chromatography-mass spectrometry
    Ana Juan-García
    Laboratori de Bromatologia i Toxicologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    J Chromatogr A 1050:119-27. 2004
    A liquid chromatography-mass spectrometry method has been developed for determining bitertanol, carboxin, flutriafol, pyrimethanil, tebuconazole and triadimefon...
  12. doi Earthworm ecotoxicological assessments of pesticides used to treat seeds under tropical conditions
    Paulo Roger L Alves
    Dep of Soil Science, University of Sao Paulo, Pádua Dias, 11, 13416 260 Piracicaba, Brazil Dep of Agronomy, Universidade Estadual de Londrina, 86051 990 Londrina, Brazil
    Chemosphere 90:2674-82. 2013
    ..quantified the impact of the insecticides imidacloprid, fipronil, and thiametoxam, and the fungicides captan and carboxin+thiram, all of which are used in the chemical treatment of crop seeds, on the survival, reproduction, and ..
  13. doi Synthesis and antifungal activity of N-(substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives
    Zhibing Wu
    State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering, Key Laboratory of Green Pesticides and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China
    Molecules 17:14205-18. 2012
    ..zeae at 100 µg/mL, which was better than that of the commercial fungicides carboxin and boscalid.
  14. ncbi Biological protection of the main cereals against fungal specific diseases
    J Hysek
    Research Institute of Crop Production Drnovska 507, CZ 16106 Prague 6, Ruzyne, Czech Republic
    Commun Agric Appl Biol Sci 70:169-73. 2005
    ..Quantity of named genera was negatively influenced while yield and health status of the plants were influenced positively...
  15. pmc Predominance of a versatile-peroxidase-encoding gene, mnp4, as demonstrated by gene replacement via a gene targeting system for Pleurotus ostreatus
    Tomer M Salame
    Department of Plant Pathology and Microbiology, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    Appl Environ Microbiol 78:5341-52. 2012
    ..ostreatus PC9 homokaryon Δku80 strain, using carboxin resistance complemented by the development of a protocol for hygromycin B resistance protoplast-based DNA ..
  16. pmc Enhancement of ganoderic acid accumulation by overexpression of an N-terminally truncated 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in the basidiomycete Ganoderma lucidum
    Jun Wei Xu
    State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
    Appl Environ Microbiol 78:7968-76. 2012
    ..The results showed that the mutated sdhB successfully conferred carboxin resistance upon transformation...
  17. doi Risk assessment studies on succinate dehydrogenase inhibitors, the new weapons in the battle to control Septoria leaf blotch in wheat
    Bart A Fraaije
    Rothamsted Research, Plant Pathology and Microbiology Department, Harpenden, Hertfordshire AL5 2JQ, UK
    Mol Plant Pathol 13:263-75. 2012
    ..graminicola. UV mutagenesis was conducted to obtain a library of carboxin-resistant mutants. A range of SDHI resistance-conferring mutations was found in Sdh subunits B, C and D...
  18. doi Cloning and characterization of the gene for the iron-sulfur subunit of succinate dehydrogenase from the violet root rot fungus, Helicobasidium mompa
    Sanae Kano
    Department of Life System Science, Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima, Shobara, Hiroshima, Japan
    J Basic Microbiol 52:132-40. 2012
    ..One of these clusters contains a critical histidine residue implicated in carboxin sensitivity in the basidiomycetes. Only one copy of the gene was present in the genome of H...
  19. pmc Mutagenesis and functional studies with succinate dehydrogenase inhibitors in the wheat pathogen Mycosphaerella graminicola
    Gabriel Scalliet
    Syngenta Crop Protection Münchwilen AG, Stein, Switzerland
    PLoS ONE 7:e35429. 2012
    ....
  20. doi Consumption of pesticide-treated wheat seed by a rural population in Malawi
    Joshua G Schier
    Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Expo Sci Environ Epidemiol 22:569-73. 2012
    ..Unwashed and washed seed samples contained, respectively: carboxin, 244 and 57 p.p.m.; pirimiphos methyl, 8.18 and 8.56 p.p.m.; total permethrin, 3.62 and 3.27 p.p.m...
  21. ncbi Soil bioassay for studying behavioral responses of wireworms (Coleoptera: Elateridae) to insecticide-treated wheat seed
    Willem G van Herk
    Agriculture and Agri Food Canada, Pacific Agri Food Research Center, Agassiz, British Columbia, Canada
    Environ Entomol 36:1441-9. 2007
    ..Wireworms exposed to Vitavax Dual (containing the organochlorine lindane) were not repelled after feeding and showed symptoms of illness for up to 28 d before making a full recovery (89%) or dying (11%)...
  22. ncbi Effect of fungicide seed treatments on N2-fixation and nodulation in pea, Pisum sativum L
    M Sajid Aqeel Ahmad
    Department of Botany, University of Agriculture Faisalabad, Pakistan
    Bull Environ Contam Toxicol 77:896-904. 2006
  23. ncbi Differences in photosynthetic activity, chlorophyll and carotenoid levels, and in chlorophyll fluorescence parameters in green sun and shade leaves of Ginkgo and Fagus
    Gulmira Sarijeva
    Botanisches Institut II, University of Karlsruhe, Kaiserstrasse 12, D 76128 Karlsruhe, Germany
    J Plant Physiol 164:950-5. 2007
    ..The results clearly demonstrate that the fan-shaped gymnosperm ginkgo leaves show the same high and low irradiance adaptation response as the angiosperm beech leaves...
  24. ncbi Transformation of Mucor circinelloides with autoreplicative vectors containing homologous and heterologous ARS elements and the dominant Cbx(r) carboxine-resistance gene
    R Ortiz-Alvarado
    Instituto de Investigacion en Biologia Experimental, Facultad de Quimica, Universidad de Guanajuato, Noria Alta s n, Apartado Postal 187, Guanajuato, Gto, 36000, Mexico
    Curr Microbiol 52:178-81. 2006
    ..The presence of autoreplicating plasmid molecules in the transformants was demonstrated by mitotic stability experiments, by Southern analysis, and by the rescue of plasmids from transformed bacterial cells...
  25. ncbi Controlling food-contaminating fungi by targeting their antioxidative stress-response system with natural phenolic compounds
    Jong H Kim
    Plant Mycotoxin Research Unit, Western Regional Research Center, USDA ARS, 800 Buchanan St, Albany, CA 94710, USA
    Appl Microbiol Biotechnol 70:735-9. 2006
    ..g., vanillyl acetone) resulted in a 100- to 1,000-fold greater sensitivity to strobilurin or carboxin fungicides...
  26. pmc 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme
    Li Shar Huang
    Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Biol Chem 281:5965-72. 2006
    ....
  27. ncbi Molecular breeding of white rot fungus Pleurotus ostreatus by homologous expression of its versatile peroxidase MnP2
    Takahisa Tsukihara
    Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho Uji, Kyoto, 611 0011, Japan
    Appl Microbiol Biotechnol 71:114-20. 2006
    ..ostreatus strain by cotransformation with a carboxin-resistant marker plasmid...
  28. ncbi Antifungal synergistic effect of scopoletin, a hydroxycoumarin isolated from Melia azedarach L. fruits
    María C Carpinella
    CEPROCOR, Agencia Córdoba Ciencia S E, Alvarez de Arenales 230, Barrio Juniors, X5004AAP Córdoba, Argentina
    J Agric Food Chem 53:2922-7. 2005
    ..The same level of effectiveness was observed when the synthetic antifungal agents Mancozeb and Carboxin were each combined with compounds 1-4, in which cases it became possible to decrease the effective concentrations ..
  29. ncbi Fungicide seed treatment efficacy against Microdochium nivale and M. majus in vitro and in vivo
    Neil C Glynn
    Harper Adams University College, Newport, Shropshire TF10 8NB, UK
    Pest Manag Sci 64:793-9. 2008
    ..The aim was firstly to determine the efficacy of fungicide seed treatments towards single-spore isolates of M. majus and M. nivale using in vitro experiments, and subsequently to determine efficacy in vivo over a range of temperatures...
  30. ncbi Toxicity of fungicides to natural bacterial communities in wetland water and sediment measured using leucine incorporation and potential denitrification
    Susann Milenkovski
    Chemical Ecology Ecotoxicology, Department of Ecology, Lund University, Ecology Building, SE 223 62, Lund, Sweden
    Ecotoxicology 19:285-94. 2010
    ..The effects of eight fungicides (benomyl, carbendazim, carboxin, captan, cycloheximide, fenpropimorph, propiconazole, and thiram), two bactericides (bronopol and ..
  31. pmc Establishing molecular tools for genetic manipulation of the pleuromutilin-producing fungus Clitopilus passeckerianus
    Sreedhar Kilaru
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, United Kingdom
    Appl Environ Microbiol 75:7196-204. 2009
    ..Three dominant selectable marker systems based on hygromycin, phleomycin, and carboxin selection were used to study the feasibility of PEG-mediated transformation of C. passeckerianus...
  32. doi New capabilities for Mycosphaerella graminicola research
    Judith Bowler
    Syngenta, Jealott s Hill International Research Centre, Bracknell, Berkshire, UK
    Mol Plant Pathol 11:691-704. 2010
    ..graminicola, namely G418 and the fungicide carboxin; (ii) the generation of a strain of M...
  33. ncbi Five carboxin-resistant mutants exhibited various responses to carboxin and related fungicides
    Yoko Shima
    Food Biotechnology Division, National Food Research Institute, National Agriculture and Food Research Organization, 2 1 12 Kannondai, Tsukuba, Ibaraki 305 8642, Japan
    Biosci Biotechnol Biochem 75:181-4. 2011
    Five carboxin-resistant mutants from Aspergillus oryzae were characterized by the sensitivities of their mycelial growth and succinate dehydrogenase (SDH) activity to carboxin and three related fungicides...
  34. ncbi Microwave-assisted and continuous flow multistep synthesis of 4-(pyrazol-1-yl)carboxanilides
    David Obermayer
    Christian Doppler Laboratory for Microwave Chemistry CDLMC and Institute of Chemistry, Karl Franzens University Graz, Heinrichstrasse 28, A 8010 Graz, Austria
    J Org Chem 76:6657-69. 2011
    ....
  35. ncbi Quantifiable downregulation of endogenous genes in Agaricus bisporus mediated by expression of RNA hairpins
    Ana S M B Costa
    Warwick HRI, University of Warwick, Wellesbourne, Warwickshire, CV35 9EF, U K
    J Microbiol Biotechnol 19:271-6. 2009
    ..Hairpin constructs for genes encoding orotidine 5'- monophosphate decarboxylase (URA3) and carboxin resistance (CBX) were introduced into A. bisporus using Agrobacteriummediated transfection...
  36. doi Transient transformation of the obligate biotrophic rust fungus Uromyces fabae using biolistics
    Alma Djulic
    Phytopathologie, Fachbereich Biologie, Universitat Konstanz, Universitätsstr 10, 78457 Konstanz, Germany
    Fungal Biol 115:633-42. 2011
    ..In addition to the delivery of color markers, an in planta selection procedure using the fungicide Carboxin was established allowing the propagation of transformants...
  37. doi The dominant Hc.Sdh (R) carboxin-resistance gene of the ectomycorrhizal fungus Hebeloma cylindrosporum as a selectable marker for transformation
    Chrisse Ngari
    Universite de Lyon, France
    Curr Genet 55:223-31. 2009
    ..Sdh (R) that confers carboxin-resistance was isolated from a UV mutant of this fungus...
  38. ncbi Characterization of mutations in the iron-sulphur subunit of succinate dehydrogenase correlating with Boscalid resistance in Alternaria alternata from California pistachio
    H F Avenot
    Department of Plant Pathology, University of California Davis, Kearney Agricultural Center, Parlier 93648, USA
    Phytopathology 98:736-42. 2008
    ..A cross-resistance study revealed that the same isolates were also resistant to carboxin, a known inhibitor of succinate dehydrogenase (Sdh). To determine the genetic basis of boscalid resistance in A...
  39. ncbi The effect of Pythium oligandrum and chitosan used in control of potato against late blight and the occurrence of fungal diseases on tuber peel
    H Kurzawińska
    Department of Plant Protection, Agricultural University, Krakow, Poland
    Commun Agric Appl Biol Sci 72:967-71. 2007
    ..Moreover the percent of diseased tubers infected by pathogens with tested preparations combination was significant lower than in control...
  40. doi Transformation of an oleaginous zygomycete Mortierella alpina 1S-4 with the carboxin resistance gene conferred by mutation of the iron-sulfur subunit of succinate dehydrogenase
    Akinori Ando
    Kyoto University, Sakyo ku, Japan
    Curr Genet 55:349-56. 2009
    ..residue within the third cysteine-rich cluster of SdhB replaced by a leucine residue) and is known to confer carboxin resistance. We succeeded in transforming M...
  41. ncbi Phototransformation of carboxin in water. Toxicity of the pesticide and its sulfoxide to aquatic organisms
    Marina Dellagreca
    Dipartimento di Chimica Organica e Biochimica, Universita Federico II, Complesso Universitario Monte S Angelo, Via Cinthia 4, I 80126 Naples, Italy
    J Agric Food Chem 52:6228-32. 2004
    Sunlight exposure of aqueous suspensions of carboxin (1) causes its phototransformation to sulfoxide 2 and minor components. Similar effects are observed in the presence of humic acid or nitrate or at different pH values...
  42. ncbi Carboxin resistance in Paracoccus denitrificans conferred by a mutation in the membrane-anchor domain of succinate:quinone reductase
    M Matsson
    Department of Microbiology, Lund University, Sölvegatan 12, S 22362 Lund, Sweden
    Arch Microbiol 170:27-37. 1998
    Succinate:quinone reductase is a membrane-bound enzyme of the citric acid cycle and the respiratory chain. Carboxin is a potent inhibitor of the enzyme of certain organisms...
  43. ncbi Liquid chromatographic analysis in mouse, dog and human plasma; stability, absorption, metabolism and pharmacokinetics of the anti-HIV agent 2-chloro-5-(2-methyl-5,6-dihydro-1,4-oxathiin-3-yl carboxamido) isopropylbenzoate (NSC 615985, UC84)
    A A Nomeir
    Arthur D Little, Inc, Cambridge, MA, USA
    J Pharm Biomed Anal 17:27-38. 1998
    ....
  44. ncbi Characterization of a split respiratory pathway in the wheat "take-all" fungus, Gaeumannomyces graminis var. tritici
    T Joseph-Horne
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, Bristol, BS41 9AF, United Kingdom
    J Biol Chem 273:11127-33. 1998
    ..graminis tritici. These results are discussed in relation to current understanding of fungal electron transfer and to the possible contribution of alternative redox centers in ATP synthesis...
  45. ncbi Models which explain the inhibition of reverse transcriptase by HIV-1-specific (thio)carboxanilide derivatives
    R M Esnouf
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Biochem Biophys Res Commun 234:458-64. 1997
    ..They further predict that mutations to Phe227, Trp229, or Leu234 might confer resistance. Since these are not observed, some constraining structural or functional role for these residues in the active enzyme is suggested...
  46. pmc Highly potent oxathiin carboxanilide derivatives with efficacy against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus isolates
    R W Buckheit
    Virology Research Group, Southern Research Institute Frederick Research Center, Maryland 21701, USA
    Antimicrob Agents Chemother 41:831-7. 1997
    ..The favorable anti-HIV properties of the UC compounds suggest they should be considered for further clinical development...
  47. pmc Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase
    G Borkow
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Virol 71:3023-30. 1997
    ..These unique properties of UC781 indicate that this nonnucleoside inhibitor may have considerable promise for use in retrovirucidal formulations to minimize the spread of HIV from infected to noninfected individuals...
  48. ncbi The role of genotypic heterogeneity in wild type virus populations on the selection of nonnucleoside reverse transcriptase inhibitor-resistant viruses
    T L Kinjerski
    Virology Research Group, Southern Research Institute, Frederick Research Center, Maryland 21701, USA
    Antiviral Res 33:109-15. 1997
    ....
  49. pmc Identification of novel thiocarboxanilide derivatives that suppress a variety of drug-resistant mutant human immunodeficiency virus type 1 strains at a potency similar to that for wild-type virus
    J Balzarini
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Antimicrob Agents Chemother 40:1454-66. 1996
    ..UC-781 and UC-82 should be considered potential candidate drugs for the treatment of HIV-1-infected individuals...
  50. pmc Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type-1-specific compounds related to oxathiin carboxanilide
    R W Buckheit
    Virology Research Group, Southern Research Institute Frederick Research Center, Maryland 21701, USA
    Antimicrob Agents Chemother 39:2718-27. 1995
    ..The merits of selecting potential candidate anti-HIV agents to be used in rational combination drugs design as part of an armamentarium of highly active anti-HIV compounds are discussed...
  51. ncbi Biological and biochemical anti-human immunodeficiency virus activity of UC 38, a new non-nucleoside reverse transcriptase inhibitor
    J B McMahon
    Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland, USA
    J Pharmacol Exp Ther 276:298-305. 1996
    ..The favorable physical characteristics, lack of toxicity, potency and bioavailability of UC 38 may make it a candidate for combination chemotherapy of acquired immune deficiency syndrome...
  52. ncbi Activity of various thiocarboxanilide derivatives against wild-type and several mutant human immunodeficiency virus type 1 strains
    J Balzarini
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Antiviral Res 27:219-36. 1995
    ..One of the most potent HIV-1 inhibitors among the thiocarboxanilide derivatives, namely UC38, selected for a mutant virus strain in which Lys at position 101 and Gly at position 190 of the reverse transcriptase was replaced by Glu...
  53. ncbi Synergistic inhibition of HIV-1 reverse transcriptase DNA polymerase activity and virus replication in vitro by combinations of carboxanilide nonnucleoside compounds
    R S Fletcher
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Biochemistry 34:10106-12. 1995
    ..We believe this to be the first example of synergistic inhibition of HIV-1 RT by combinations of structurally related nonnucleoside inhibitors...
  54. pmc Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives)
    J Balzarini
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Proc Natl Acad Sci U S A 92:5470-4. 1995
    ....
  55. ncbi Carboxanilide derivative non-nucleoside inhibitors of HIV-1 reverse transcriptase interact with different mechanistic forms of the enzyme
    R S Fletcher
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Biochemistry 34:4346-53. 1995
    ..In contrast, UC38 completely photoprotected the RT-P/T-dNTP ternary complex, but not free RT or the RT-P/T binary complex. UC84 and UC38 thus appear to bind to different mechanistic forms of RT in the polymerase reaction sequence...
  56. ncbi Genotoxic effects of some systemic pesticides: in vivo chromosomal aberrations in bone marrow cells in rats
    N Adhikari
    Department of Biology, Guru Nanak Dev University, Amritsar, India
    Environ Mol Mutagen 12:235-42. 1988
    ..It was observed that 2,4-D, dimecron, and vitavax were clastogenic, but the results obtained with benomyl and monocrotophos were equivocal...
  57. ncbi Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives
    J Ren
    Laboratory of Molecular Biophysics, Oxford, UK
    Biochemistry 37:14394-403. 1998
    ..This in turn explains the differences in the effect of mutated residues on the binding of these compounds...
  58. ncbi Lack of evidence for antisense suppression in the fungal plant pathogen Ustilago maydis
    J P Keon
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, UK
    Antisense Nucleic Acid Drug Dev 9:101-4. 1999
    ..This was despite detection of high levels of antisense RNA transcripts in cells transformed with the Pyr3 antisense vector...
  59. ncbi Succinate:quinone oxidoreductase in the bacteria Paracoccus denitrificans and Bacillus subtilis
    Lars Hederstedt
    Department of Microbiology, Lund University, Sölvegatan 12, SE 223 62, Lund, Sweden
    Biochim Biophys Acta 1553:74-83. 2002
    ..oxidoreductase that is similar to that of mammalian mitochondria with respect to composition and sensitivity to carboxin. Results obtained with carboxin-resistant P...
  60. ncbi Construction of a homologous selectable marker gene for Lentinula edodes transformation
    Toshikazu Irie
    Iwate Biotechnology Research Center, Kitakami, Iwate, Japan
    Biosci Biotechnol Biochem 67:2006-9. 2003
    ..protein (Ip) subunit from an edible mushroom, Lentinula edodes, and introduced a point mutation that confers carboxin resistance into it. The mutant gene successfully transformed L. edodes with high efficiency (9 transformants/2...
  61. ncbi Stimulation by surangin B of endogenous amino acid release from synaptosomes
    Yanshen Deng
    Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada V5A 1S6
    Toxicon 42:351-7. 2003
    ..CCCP; an uncoupler), were more potent releasers of amino acids from synaptosomes than surangin B, however, carboxin (a complex II-selective inhibitor), was extremely weak to ineffective in this regard...
  62. ncbi Segmental analysis of molecular surface electrostatic potentials: application to enzyme inhibition
    Tore Brinck
    Department of Physical Chemistry, Royal Institute of Technology, 100 44, Stockholm, Sweden
    J Mol Model 9:77-83. 2003
    ..This initial exploratory study shows that segmental analysis can provide insight into the nature of the process being investigated, as well as possibly enhancing the predictive capability...
  63. ncbi Effects of different plant protection programs on soil microbes
    J H Ahtiainen
    Research Laboratory, Finnish Environmental Institute, Hakuninmaantie 4 6, PO Box 140, Helsinki FIN 00430, Finland
    Ecotoxicol Environ Saf 54:56-64. 2003
    ..The herbicides used were chlorsulfuron, MCPA, and bentazone; the fungicides carboxin-imazalin and propiconazole; and the insecticides dimethoate and pirimicarb...
  64. pmc A gene from Aspergillus nidulans with similarity to URE2 of Saccharomyces cerevisiae encodes a glutathione S-transferase which contributes to heavy metal and xenobiotic resistance
    James A Fraser
    Department of Genetics, University of Melbourne, Victoria 3010, Australia
    Appl Environ Microbiol 68:2802-8. 2002
    ..in resistance to a variety of xenobiotics and metals and confers susceptibility to the systemic fungicide carboxin. Northern analysis showed that gstA transcription is strongly activated upon exposure to 1-chloro-2,4-..
  65. ncbi [Inhibitors of complex I and II of the mitochondrial respiratory chain]
    Toshiaki Miki
    Department of Physiological Chemistry, Tokyo Metropolitan Institute of Medical Science
    Nihon Rinsho 60:171-4. 2002
  66. ncbi Photochemical behaviour of the systemic fungicide carboxin
    Maria Rosaria Iesce
    Dipartimento di Chimica Organica e Biochimica, Universita degli Studi di Napoli Federico II, Complesso Universitario Monte Sant Angelo, Via Cinthia, I 80126 Napoli, Italy
    Environ Sci Pollut Res Int 9:107-9. 2002
    Irradiation of carboxin (1) with a 500 W UV lamp (filter Pyrex) in CH3CN leads to the products 3, 5-8, 12-14 depending upon the reaction conditions. All photo-products were isolated and characterized...
  67. ncbi Differences in the microflora of scarified and unscarified seeds of Karwinskia humboldtiana (Rhamnaceae)
    M Henselová
    Department of Plant Physiology, Faculty of Science, Comenius University, 842 15 Bratislava, Slovakia
    Folia Microbiol (Praha) 46:543-8. 2001
    ..Treatment of scarified seeds with Vitavax 200 WP and Pomarsol Forte 80 WP (3 mg/g seeds) augmented germination by 10-19% compared to treated unscarified seeds, and by 16-31% compared to untreated unscarified seeds...
  68. ncbi Integration of the gene for carboxin resistance does not impact the Ustilago maydis-maize interaction
    Christopher N Topp
    Department of Plant Pathology, University of Georgia, Athens, GA 30602 7274, USA
    Curr Microbiol 44:67-70. 2002
    A previous report indicated that insertion of the carboxin resistance (cbxR) gene into the Ustilago maydis genome impaired the pathogenic ability of the fungus towards Zea mays, the corn host...
  69. ncbi The carboxin-binding site on Paracoccus denitrificans succinate:quinone reductase identified by mutations
    M Matsson
    Department of Microbiology, Lund University, Sweden
    J Bioenerg Biomembr 33:99-105. 2001
    Succinate:quinone reductase catalyzes electron transfer from succinate to quinone in aerobic respiration. Carboxin is a specific inhibitor of this enzyme from several different organisms...
  70. ncbi Phytotoxicity of pathogenic fungi and their mycotoxins to cereal seedling viability
    H A Hasan
    Botany Department, Faculty of Science, Assiut University, Assiut, Egypt
    Mycopathologia 148:149-55. 1999
    ..Grain treated with carboxin-captan and thiophanatemethyl-thiram at 1 g kg-1 grain increased the seedlings vigour of wheat in sterilized soil ..
  71. ncbi Designs and syntheses of oxathiin carboxanilide analogues and their antiviral activities
    H G Hahn
    Korea Institute of Science and Technology, Seoul
    Arch Pharm Res 23:315-23. 2000
    ..But the trifluoromethylated dithiin (24f) showed higher inhibitory activity against PV-1 and CoxB-3 virus than commercial antiviral agents, ribavirin (RV)...
  72. ncbi Shuttle vectors for genetic manipulations in Ustilago maydis
    M Kojic
    Department of Microbiology and Immunology, Cornell University Weill Medical College, New York, NY 10021, USA
    Can J Microbiol 46:333-8. 2000
    ..Sets of plasmids selectable in media containing geneticin, carboxin, nourseothricin, or hygromycin, able to replicate autonomously, to transform U...
  73. ncbi Inhibition of mitochondrial oxidative phosphorylation induces hyper-expression of glutamic acid decarboxylase in pancreatic islet cells
    M A Myers
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Autoimmunity 30:43-51. 1999
    ..These results represent the first evidence that GAD expression is enhanced under conditions that are toxic to pancreatic beta cells, and establish a link between mitochondrial dysfunction and expression of IDDM autoantigens...
  74. pmc Oxathiin carboxanilide, a potent inhibitor of human immunodeficiency virus reproduction
    J P Bader
    Division of Cancer Treatment, National Cancer Institute, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 88:6740-4. 1991
    ..OC represents a new class of anti-HIV agents that are promising candidates for drug development...

Research Grants1

  1. ELECTRON CARRIERS IN CYANIDE-RESISTANT RESPIRATION
    JAMES SIEDOW; Fiscal Year: 1980
    ..Two inhibitors, dibromothymoquinone and carboxin are being used to characterize the roles of ubiquinone and center S-3 respectively in cyanide-resistant electron ..