thiobarbituric acid reactive substances

Summary

Summary: Low-molecular-weight end products, probably malondialdehyde, that are formed during the decomposition of lipid peroxidation products. These compounds react with thiobarbituric acid to form a fluorescent red adduct.

Top Publications

  1. ncbi Increased oxidative stress in obesity and its impact on metabolic syndrome
    Shigetada Furukawa
    Department of Medicine and Pathophysiology, Graduate School of Medicine, Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    J Clin Invest 114:1752-61. 2004
  2. ncbi Method for the measurement of antioxidant activity in human fluids
    D Koracevic
    Institute of Biochemistry, Medical Faculty, University Clinical Center, Nis, Yugoslavia
    J Clin Pathol 54:356-61. 2001
  3. ncbi Decreased blood oxidative stress after repeated muscle-damaging exercise
    Michalis G Nikolaidis
    Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece
    Med Sci Sports Exerc 39:1080-9. 2007
  4. ncbi Strenuous endurance training in humans reduces oxidative stress following exhausting exercise
    H Miyazaki
    Institute of Health and Sport Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8574, Japan
    Eur J Appl Physiol 84:1-6. 2001
  5. ncbi Protective effects of Digera muricata (L.) Mart. on testis against oxidative stress of carbon tetrachloride in rat
    Muhammad Rashid Khan
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    Food Chem Toxicol 47:1393-9. 2009
  6. ncbi Oxidative stress and pathogenesis of inflammatory bowel disease: an epiphenomenon or the cause?
    Ali Rezaie
    Department of Community Health Medicine, Faculty of Medicine, University of Calgary, Calgary, Canada
    Dig Dis Sci 52:2015-21. 2007
  7. ncbi Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects
    U J Jung
    Department of Food Science and Nutrition, Kyungpook National University, Daegu, South Korea
    Clin Nutr 22:561-8. 2003
  8. ncbi Serum PON1 arylesterase activity in relation to hyperhomocysteinaemia and oxidative stress in young adult central retinal venous occlusion patients
    N Angayarkanni
    Biochemistry Research Department, Sankara Nethralaya, Vision Research Foundation, Chennai, India
    Eye (Lond) 22:969-74. 2008
  9. ncbi Antioxidant enzymes and paraoxonase show a co-activity in preserving low-density lipoprotein from oxidation
    E Y Sozmen
    Department of Biochemistry, Ege University Faculty of Medicine, Izmir, Turkey
    Clin Exp Med 1:195-9. 2001
  10. ncbi Aqueous extract of Ilex paraguariensis attenuates the progression of atherosclerosis in cholesterol-fed rabbits
    Ana Luiza Pamplona Mosimann
    Department of Clinical Analysis, Health Sciences Center, Federal University of Santa Catarina, , SC, Brazil
    Biofactors 26:59-70. 2006

Research Grants

  1. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank Anania; Fiscal Year: 2009
  2. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank A Anania; Fiscal Year: 2010
  3. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank Anania; Fiscal Year: 2007
  4. Ambient Air Pollution, Preeclampsia, and Preterm Delivery
    Michelle Williams; Fiscal Year: 2007
  5. Ambient Air Pollution, Preeclampsia/Preterm Delivery
    CAROLE RUDRA; Fiscal Year: 2006
  6. Novel Antioxidant Mechanisms of Surfactant Proteins
    Francis McCormack; Fiscal Year: 2006
  7. Point-of-Care Measurement of Glycated Hemoglobin
    MARGO COHEN; Fiscal Year: 2004
  8. Glycemic Control and Progression of Diabetic Retinopathy
    Renu A Kowluru; Fiscal Year: 2010
  9. Role of Ras in Retinal Cell Death in Diabetes
    Renu A Kowluru; Fiscal Year: 2010
  10. Glycemic Control and Progression of Diabetic Retinopathy
    Renu A Kowluru; Fiscal Year: 2010

Detail Information

Publications207 found, 100 shown here

  1. ncbi Increased oxidative stress in obesity and its impact on metabolic syndrome
    Shigetada Furukawa
    Department of Medicine and Pathophysiology, Graduate School of Medicine, Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    J Clin Invest 114:1752-61. 2004
    ....
  2. ncbi Method for the measurement of antioxidant activity in human fluids
    D Koracevic
    Institute of Biochemistry, Medical Faculty, University Clinical Center, Nis, Yugoslavia
    J Clin Pathol 54:356-61. 2001
    ..To develop a new, simple, and cheap method for estimating antioxidant activity in human fluids...
  3. ncbi Decreased blood oxidative stress after repeated muscle-damaging exercise
    Michalis G Nikolaidis
    Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece
    Med Sci Sports Exerc 39:1080-9. 2007
    ..To examine the effect of repeated muscle-damaging exercise on the time-course changes in several indices of muscle damage, and to compare them with changes in blood oxidative stress indices...
  4. ncbi Strenuous endurance training in humans reduces oxidative stress following exhausting exercise
    H Miyazaki
    Institute of Health and Sport Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8574, Japan
    Eur J Appl Physiol 84:1-6. 2001
    ..production in response to exhausting exercise. Furthermore, this up-regulation in antioxidant defences was accompanied by a reduction in exercise-induced lipid peroxidation in erythrocyte membrane...
  5. ncbi Protective effects of Digera muricata (L.) Mart. on testis against oxidative stress of carbon tetrachloride in rat
    Muhammad Rashid Khan
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    Food Chem Toxicol 47:1393-9. 2009
    ..muricata treatment augments the antioxidants defense mechanism against carbon tetrachloride induced toxicity and provides evidence that it may have a therapeutic role in free radical mediated diseases...
  6. ncbi Oxidative stress and pathogenesis of inflammatory bowel disease: an epiphenomenon or the cause?
    Ali Rezaie
    Department of Community Health Medicine, Faculty of Medicine, University of Calgary, Calgary, Canada
    Dig Dis Sci 52:2015-21. 2007
    ..Moreover, the effects of antioxidant therapy on IBD patients in randomized, controlled trials were reviewed and the need for further studies elaborated. We also summarized the evidence in support for causality of oxidative stress in IBD...
  7. ncbi Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects
    U J Jung
    Department of Food Science and Nutrition, Kyungpook National University, Daegu, South Korea
    Clin Nutr 22:561-8. 2003
    ..CONCLUSIONS: Therefore, these data suggest that naringin may play an important role in lowering plasma cholesterol and regulating the antioxidant capacity in hypercholesterolemic subjects...
  8. ncbi Serum PON1 arylesterase activity in relation to hyperhomocysteinaemia and oxidative stress in young adult central retinal venous occlusion patients
    N Angayarkanni
    Biochemistry Research Department, Sankara Nethralaya, Vision Research Foundation, Chennai, India
    Eye (Lond) 22:969-74. 2008
    ....
  9. ncbi Antioxidant enzymes and paraoxonase show a co-activity in preserving low-density lipoprotein from oxidation
    E Y Sozmen
    Department of Biochemistry, Ege University Faculty of Medicine, Izmir, Turkey
    Clin Exp Med 1:195-9. 2001
    ..Since these enzymes all show activity against low-density lipoprotein oxidation, we propose that future investigations on atherosclerotic processes should address PON1 polymorphism as well as PON1 and other antioxidant enzymes...
  10. ncbi Aqueous extract of Ilex paraguariensis attenuates the progression of atherosclerosis in cholesterol-fed rabbits
    Ana Luiza Pamplona Mosimann
    Department of Clinical Analysis, Health Sciences Center, Federal University of Santa Catarina, , SC, Brazil
    Biofactors 26:59-70. 2006
    ..05). The results showed that Ilex paraguariensis extract can inhibit the progression of atherosclerosis in cholesterol-fed rabbits, although it did not decrease the serum cholesterol or aortic TBARS and antioxidant enzymes...
  11. ncbi Utility of the TBARS assay in detecting oxidative stress in white sucker (Catostomus commersoni) populations exposed to pulp mill effluent
    Ken D Oakes
    Department of Zoology, University of Guelph, Guelph, Ont, Canada N1G 2W1
    Aquat Toxicol 63:447-63. 2003
    ..This study indicates oxidative stress could be a mechanism of toxicity in fish exposed to pulp mill effluent and demonstrates the utility of TBARS in delineating zones of exposure to pulp mill effluent...
  12. ncbi Serum levels of thiobarbituric acid reactive substances predict cardiovascular events in patients with stable coronary artery disease: a longitudinal analysis of the PREVENT study
    Mary F Walter
    Elucida Research, Beverly, Massachusetts, USA
    J Am Coll Cardiol 44:1996-2002. 2004
    ..METHODS: Serum MDA levels were measured as thiobarbituric acid reactive substances (TBARS) in 634 patients with documented CAD using reverse-phase high-performance liquid ..
  13. ncbi Detoxification and oxidative stress responses along with microcystins accumulation in Japanese quail exposed to cyanobacterial biomass
    Veronika Paskova
    Centre for Cyanobacteria and Their Toxins Institute of Botany, The Academy of Sciences of the Czech Republic and RECETOX, Masaryk University, Brno, Czech Republic
    Sci Total Environ 398:34-47. 2008
    ..The data also suggest that increased activities of detoxification enzymes could lead to greater biotransformation and elimination of the MCs at the longer exposure time...
  14. ncbi Sampling time is crucial for measurement of aerobic exercise-induced oxidative stress
    Yiannis Michailidis
    Department of Physical Education and Sport Science, Democritus University of Thrace, Komotini, Greece
    Med Sci Sports Exerc 39:1107-13. 2007
    ..To thoroughly investigate the time-course changes of several commonly used markers of oxidative stress by performing serial measurements during a 24-h period after an acute bout of strenuous cardiovascular exercise...
  15. ncbi Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects
    Devjit Tripathy
    Division of Endocrinology, Diabetes and Metabolism, State University of New York and Kaleida Health, Buffalo, New York 14209, USA
    Diabetes 52:2882-7. 2003
    ..1% (P < 0.01) at 2, 4, and 6 h, respectively. We conclude that an increase in FFA concentration induces oxidative stress and has a proinflammatory effect; it also impairs postischemic flow-mediated vasodilation of the brachial artery...
  16. ncbi Inhibition of lipid peroxidation by botanical extracts of Ocimum sanctum: in vivo and in vitro studies
    R Kedlaya Geetha
    DVS College of Arts and Science, Shimoga, Pin 577 201, Karnataka, India
    Life Sci 76:21-8. 2004
    ..Aqueous extract feeding also provided significant liver and aortic tissue protection from hypercholesterolemia-induced peroxidative damage...
  17. ncbi Increased oxidative stress indices in the blood of child swimmers
    Sofia Gougoura
    Department of Biochemistry and Biotechnology, University of Thessaly, 26 Ploutonos Str, 41221 Larissa, Greece
    Eur J Appl Physiol 100:235-9. 2007
    ....
  18. ncbi Lipid peroxidation and antioxidant status in preeclampsia: a systematic review
    Sajal Gupta
    Glickman Urological and Kidney Institute, Cleveland, OH 44195, USA
    Obstet Gynecol Surv 64:750-9. 2009
    ..Preeclampsia is characterized by increased lipid peroxidation and diminished antioxidant capacity; however, there is no consensus as to the extent of these conditions...
  19. ncbi 4-hydroxycinnamate lowers plasma and hepatic lipids without changing antioxidant enzyme activities
    Jeong-Sun Lee
    Department of Food Science and Nutrition, Kyungpook National University, Taegu, Korea
    Ann Nutr Metab 47:144-51. 2003
    ..CONCLUSION: These results indicate that 4-(OH)-C was effective in lowering the plasma cholesterol and hepatic lipids...
  20. ncbi Pancreas beta-cells morphology, liver antioxidant enzymes and liver oxidative parameters in alloxan-resistant and alloxan-susceptible Wistar rats: a viable model system for the study of concepts into reactive oxygen species
    Guilherme Antonio Behr
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Fundam Clin Pharmacol 22:657-66. 2008
    ..These results suggest an increased regenerative or recovery process in the ALR rat pancreatic islets and an increased hepatic antioxidant defenses in these group of alloxan-resistant rats...
  21. ncbi Serum oxidant and antioxidant status during early and late recovery periods following an all-out 21-km run in trained adolescent runners
    Ye Tian
    China Institute of Sport Science, 11 Tiyuguan Road, Chongwen District, Beijing, China
    Eur J Appl Physiol 110:971-6. 2010
    ....
  22. ncbi Acute exhaustive exercise does not alter lipid peroxidation levels and antioxidant enzyme activities in rat hippocampus, prefrontal cortex and striatum
    Osman Acikgoz
    Dokuz Eylul University, School of Medicine, Department of Physiology, Balcova, 35340 Izmir, Turkey
    Neurosci Lett 406:148-51. 2006
    ..The aim of this study was to investigate the effects of exhaustive exercise on thiobarbituric acid reactive substances, as an indicator of lipid peroxidation, in the hippocampus, prefrontal cortex and striatum...
  23. ncbi Influence of dietary vitamin E and C supplementation on vitamin E and C content and thiobarbituric acid reactive substances (TBARS) in different tissues of growing pigs
    Barbara Eichenberger
    Institute of Animal Sciences, Nutrition Biology, Swiss Federal Institute of Technology (ETH) Zurich, Switzerland
    Arch Anim Nutr 58:195-208. 2004
    ..In backfat outer layer vitamin E was positively correlated with rancimat induction time (r = 0.550) and negatively with TBARS (r = -0.202), but provided no evidence that dietary vitamin E supply led to better oxidative stability...
  24. ncbi Effects of footshock stress on superoxide dismutase and glutathione peroxidase enzyme activities and thiobarbituric acid reactive substances levels in the rat prefrontal cortex and striatum
    S Gonenc
    Department of Physiology, Dokuz Eylul University Medical School, Balcova, 35340, Izmir, Turkey
    Neurosci Lett 289:107-10. 2000
    ..Stress did not change superoxide dismutase activity and thiobarbituric acid reactive substances levels...
  25. ncbi Lipid-lowering and antioxidant effects of an ethyl acetate extract of fenugreek seeds in high-cholesterol-fed rats
    Olfa Belguith-Hadriche
    Unite de recherche DGRST 02 08 20, Laboratoire de Biochimie, Faculte de Medecine de Sfax, Tunisie
    J Agric Food Chem 58:2116-22. 2010
    ..The plasma lipid levels, total phenolics, and total flavonoid contents were measured, and the thiobarbituric acid reactive substances (TBARS) and antioxidant activities were examined...
  26. ncbi Ghrelin promotes antioxidant enzyme activity and reduces lipid peroxidation in the rat ovary
    Arash Kheradmand
    Department of Clinical Sciences, School of Veterinary Medicine, University of Lorestan, P O Box 465, Khorram Abad, Iran
    Regul Pept 162:84-9. 2010
    ..for later antioxidant enzyme activity assays as well as measurement of glutathione content and thiobarbituric acid reactive substances (TBARS) level. Superoxide dismutase activity was significantly higher on days 9 (P<0...
  27. ncbi Exercise-induced oxidative stress leads hemolysis in sedentary but not trained humans
    Umit Kemal Sentürk
    Department of Physiology, Faculty of Medicine, Akdeniz University, Kampus, Antalya, Turkey
    J Appl Physiol 99:1434-41. 2005
    ..These findings suggest that the exercise-induced oxidative stress may contribute to exercise-induced hemolysis in sedentary humans...
  28. ncbi Determination of carbonyl group content in plasma proteins as a useful marker to assess impairment in antioxidant defense in patients with Eales' disease
    Mohanraj Rajesh
    Department of Biochemistry Research, Sankara Nethralaya, Chennai, India
    Indian J Ophthalmol 52:139-44. 2004
    ..Plasma protein carbonyl groups,plasma glutathione (GSH) superoxide dismutase (SOD) activity and thiobarbituric acid reactive substances (TBARS) were determined in erythrocytes...
  29. ncbi Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney
    Naveen Tirkey
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    BMC Pharmacol 5:2. 2005
    ..The present study was designed to establish the protective effect of hesperidin (HDN), a citrus bioflavonoid, on CCl4-induced oxidative stress and resultant dysfunction of rat liver and kidney...
  30. ncbi Oxidative stress in severely obese persons is greater in those with insulin resistance
    Francisco J Tinahones
    Servicio de Endocrinologia y Nutricion, Hospital Clinico Virgen de la Victoria, Malaga, Spain
    Obesity (Silver Spring) 17:240-6. 2009
    ..various antioxidant enzymes, the total antioxidant capacity (TAC) and the plasma concentration of thiobarbituric acid reactive substances (TBARS)...
  31. ncbi Iron chelation abrogates excessive formation of hydroxyl radicals and lipid peroxidation products in monocytes of patients with Eales' disease: direct evidence using electron spin resonance spectroscopy
    Mohanraj Rajesh
    Biochemistry Department, Vision Research Foundation, Sankara Nethralaya, Chennai, India
    Curr Eye Res 28:399-407. 2004
    ..Superoxide dismutase (SOD), thiobarbituric acid reactive substances (TBARS), and iron content was determined in MC to assess the oxidant thrust and antioxidant ..
  32. ncbi Involvement of oxidative and nitrosative stress in promoting retinal vasculitis in patients with Eales' disease
    Mohanraj Rajesh
    Biochemistry Research Department, Vision Research Foundation, Sankara Nethralaya, 600006 Chennai, India
    Clin Biochem 36:377-85. 2003
    ..b>Thiobarbituric acid reactive substances (TBARS) were determined by measuring malondialdehyde (MDA) formed...
  33. ncbi Accumulation of 8-hydroxydeoxyguanosine and its relationship with antioxidant parameters in patients with Eales' disease: implications for antioxidant therapy
    Mohanraj Rajesh
    Biochemistry Research Department, Vision Research Foundation, Sankara Nethralaya, Chennai, India
    Curr Eye Res 27:103-10. 2003
    ..Hence we believe antioxidant vitamin E and C supplementation might be beneficial to patients with ED...
  34. ncbi Antioxidant activity and hepatoprotective property of leaf extracts of Boerhaavia diffusa Linn against acetaminophen-induced liver damage in rats
    M Tolulope Olaleye
    Department of Biochemistry, School of Sciences, Federal University of Technology, PMB 704, Akure, Nigeria
    Food Chem Toxicol 48:2200-5. 2010
    ..These results indicated that leaf extracts from B. diffusa possess hepatoprotective property against acetaminophen-induced liver damage which may be mediated through augmentation of antioxidant defenses...
  35. ncbi Radioprotective and antioxidant properties of low-altitude Podophyllum hexandrum (LAPH)
    Rajesh Arora
    Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Delhi, India
    J Environ Pathol Toxicol Oncol 24:299-314. 2005
    ....
  36. ncbi Increase in Fe3+/Fe2+ ratio and iron-induced oxidative stress in Eales disease and presence of ferrous iron in circulating transferrin
    Radhakrishnan Selvi
    Biochemistry Research Department, Sankara Nethralaya, Vision Research Foundation, Chennai, India
    Curr Eye Res 32:677-83. 2007
    ..Total iron, ferrous iron, thiobarbituric acid reactive substances (TBARS), and ceruloplasmin were estimated in the blood samples of patients with inflammation, ..
  37. ncbi Elevated serum thiobarbituric acid reactive substances in clinically symptomatic schizophrenic males
    Clarissa Severino Gama
    Laboratório de Psiquiatria Molecular, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035 003 Porto Alegre, RS, Brazil
    Neurosci Lett 433:270-3. 2008
    ..Altered superoxide dismutase (SOD) and increased lipid peroxidation, measured by the thiobarbituric acid reactive substances (TBARS), are increased in schizophrenia...
  38. ncbi Mechanism for obesity-induced increase in myocardial lipid peroxidation
    H K Vincent
    Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, Florida, USA
    Int J Obes Relat Metab Disord 25:378-88. 2001
    ....
  39. ncbi Antioxidant effect of Boerhavia diffusa L. in tissues of alloxan induced diabetic rats
    M Amarnath Satheesh
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar 608 002, India
    Indian J Exp Biol 42:989-92. 2004
    ..The results suggest that BLEt has remarkable antidiabetic activity and can improve antioxidant status in alloxan induced diabetic rats...
  40. ncbi Lipid peroxidation and antioxidant enzyme status in Type 2 diabetics with coronary heart disease
    M M Kesavulu
    Department of Biochemistry, School of Biological and Earth Sciences, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India
    Diabetes Res Clin Pract 53:33-9. 2001
    ..The relationship between serum lipids, lipoproteins, lipid peroxides [thiobarbituric acid reactive substances (TBARS)] and erythrocyte antioxidant enzymes [catalase (CAT), glutathione peroxidase (GPx) and ..
  41. ncbi Oxidative stress and nitric oxide related parameters in type II diabetes mellitus: effects of glycemic control
    A Aydin
    Gulhane Military Medical Academy, Department of Toxicology, 06018, Etlik, Ankara, Turkey
    Clin Biochem 34:65-70. 2001
    ....
  42. ncbi Cognitive impairment of rats caused by oxidative stress and aging, and its prevention by vitamin E
    Koji Fukui
    Division of Biological Chemistry, Shibaura Institute of Technology, 3-9-14 Shibaura, Minato-ku, Tokyo 108-8548, Japan
    Ann N Y Acad Sci 959:275-84. 2002
    ..These results suggest that oxidative damage to the rat synapse in the cerebral cortex and hippocampus during aging may contribute to the deficit of cognitive functions...
  43. ncbi Fructose-enriched diet modifies antioxidant status and lipid metabolism in spontaneously hypertensive rats
    Aurelie Girard
    UPRES Lipides Nutrition EA 2422, Faculte des Sciences Gabriel, Universite de Bourgogne, Dijon, France
    Nutrition 22:758-66. 2006
    ..Changes in antioxidant defense are unknown in hypertension associated with metabolic disorders induced by high-fructose feeding...
  44. ncbi The effect of exercise training on oxidative damage of lipids, proteins, and DNA in rat skeletal muscle: evidence for beneficial outcomes
    Z Radak
    Laboratory of Exercise Physiology, Hungarian University of Physical Education, Budapest
    Free Radic Biol Med 27:69-74. 1999
    ..The concentration of thiobarbituric acid reactive substances and 4-hydroxynonenal protein adducts did not differ in the gastrocnemius muscle between exercised ..
  45. ncbi Correlates of markers of oxidative status in the general population
    M Trevisan
    Department of Social and Preventive Medicine, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY, USA
    Am J Epidemiol 154:348-56. 2001
    ..Oxidative status and antioxidant potentials appear to be significantly associated with a number of major cardiovascular disease risk factors; most of them are linked to abnormalities in glucose and insulin metabolism...
  46. ncbi Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 30:129-44. 2005
    ....
  47. ncbi Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophrenia
    Mauricio Kunz
    Laboratório de Psiquiatria Molecular, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, Programa de Pós Graduação em Medicina Psiquiatria, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, Porto Alegre, RS, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 32:1677-81. 2008
    ..There is an increasing body of evidence suggesting that oxidative stress may play a role in the pathophysiology of both schizophrenia (SZ) and bipolar disorder (BD)...
  48. ncbi Do the serum oxidative stress biomarkers provide a reasonable index of the general oxidative stress status?
    Sandro Arguelles
    Departamento de Bioquimica, Bromatologia y Toxicologia, Facultad de Farmacia, Universidad de Sevilla, Spain
    Biochim Biophys Acta 1674:251-9. 2004
    ..Our results show that only lipid peroxides in serum could be useful to predict the oxidative stress in tissues. No correlation was found between any of the oxidative stress markers in serum...
  49. ncbi Cardiopulmonary response to inhalation of biogenic secondary organic aerosol
    Jacob D McDonald
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Inhal Toxicol 22:253-65. 2010
    ..Overall, alpha-pinene-derived SOA, including SOA that included organosulfate compounds, revealed limited biological response after short-term inhalation exposures...
  50. ncbi Elevated exhalation of hydrogen peroxide and thiobarbituric acid reactive substances in patients with community acquired pneumonia
    Edyta Majewska
    Department of Experimental and Clinical Physiology, Institute of Physiology and Biochemistry, Medical University of Lodz, Mazowiecka St. 6/8, 92-215 Lodz, Poland
    Respir Med 98:669-76. 2004
    ..Determination of H2O2 in EBC may be helpful for non-invasive monitoring of oxidants production during lower respiratory tract infection...
  51. ncbi Effect of exogenous leptin administration on high fat diet induced oxidative stress
    J B Kalaivani Sailaja
    Department of Biochemistry, Annamalai University, Annamalainagar, Tamilnadu, India
    Pharmazie 59:475-9. 2004
    ..Significantly elevated levels of tissue thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD) and significantly lowered levels of glutathione and its related ..
  52. ncbi Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
    R S Vijayakumar
    Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamilnadu, India
    Redox Rep 9:105-10. 2004
    ..02 g/kg body weight) for a period of 10 weeks. Significantly elevated levels of thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD) and significantly lowered activities of superoxide dismutase (SOD)..
  53. ncbi Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats
    Salim S Al-Rejaie
    Department of Pharmacology, College of Pharmacy, King Saud University, PO Box 2457, Kingdom of Saudi Arabia
    World J Gastroenterol 15:1373-80. 2009
    ..To investigate whether carnitine deficiency is a risk factor during the development of diethylnitrosamine (DENA)-induced hepatic carcinogenesis...
  54. ncbi Effects of leptin on oxidative stress in healthy and Streptozotocin-induced diabetic rats
    Sebnem Gülen
    Department of Physiology, Faculty of Medicine, Gazi University, Ankara, Turkey
    Mol Cell Biochem 302:59-65. 2007
    ..The present study was designed to examine the effects of leptin treatment on plasma lipid peroxidation and reduced glutathion of normal and streptozotocin(STZ)-induced diabetic rats...
  55. ncbi A novel HPLC method for the measurement of thiobarbituric acid reactive substances (TBARS). A comparison with a commercially available kit
    Esben Seljeskog
    Division of Medical Biochemistry, PO Box 8100, N 4068 Stavanger, Norway
    Clin Biochem 39:947-54. 2006
    ..Most methods for the measurement of TBARS require long derivatization time and addition of antioxidants in the samples. Furthermore, comparison of these methods with commercially available HPLC kits is lacking...
  56. ncbi Oxidative stress, inflammation, and pulmonary function assessment in rats exposed to laboratory-generated pollutant mixtures
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    J Toxicol Environ Health A 71:1352-62. 2008
    ..Overall, the toxicological effects from exposure to these pollutant mixtures were subtle, but the results show differences in the effects of atmospheres having different physical/chemical characteristics...
  57. ncbi A systematic review of the effect of the Excebrane dialyser on biomarkers of lipid peroxidation
    Marie Anne Sosa
    Department of Medicine, Tufts University School of Medicine, Boston, MA 02135, USA
    Nephrol Dial Transplant 21:2825-33. 2006
    ..The summary estimate revealed a non-significant decrease in pre-dialysis thiobarbituric acid reactive substances (TBARS) level of 0.4 microM (95% CI, -1.2 to 0.4 microM; three studies)...
  58. ncbi Ocimum sanctum modulates selenite-induced cataractogenic changes and prevents rat lens opacification
    Suresh K Gupta
    Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India
    Curr Eye Res 30:583-91. 2005
    ..To study the effect of Ocimum sanctum (OS) on selenite-induced morphological and biochemical changes in isolated rat lenses as well as on cataract incidence in rat pups...
  59. ncbi Lipid peroxidation and antioxidant status in patients with periodontitis
    Kuppusamy Panjamurthy
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar - 608002, India
    Cell Mol Biol Lett 10:255-64. 2005
    ..assess the degree of oxidative stress in patients with periodontitis by measuring their levels of thiobarbituric acid reactive substances (TBARS), enzymatic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxide ..
  60. ncbi Effect of leptin on peroxidation and antioxidant defense in ethanol-supplemented Mus musculus heart
    V Balasubramaniyan
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    Fundam Clin Pharmacol 21:245-53. 2007
    ..plasma levels of leptin, lactate dehydrogenase (LDH), cardiac lipid hydroperoxides (LOOH) and thiobarbituric acid reactive substances (TBARS) and significantly decreased cardiac superoxide dismutase, catalase, vitamin C, vitamin E, ..
  61. ncbi Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos
    Dan Qiao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Toxicol Appl Pharmacol 206:17-26. 2005
    ..The balance between neuroprotectant and neurotoxicant actions of nicotine may be particularly important in situations where exposure to tobacco smoke is combined with other prooxidant insults...
  62. ncbi Antioxidant effect of Cytisus scoparius against carbon tetrachloride treated liver injury in rats
    S Raja
    School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India
    J Ethnopharmacol 109:41-7. 2007
    ..SGOT), serum glutamate pyruvate transaminases (SGPT), lactate dehydrogenase (LDH) and thiobarbituric acid reactive substances (TBARS) along with reduction of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (..
  63. ncbi Facilitated nitration and oxidation of LDL in cigarette smokers
    Y Yamaguchi
    Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    Eur J Clin Invest 35:186-93. 2005
    ..We investigated whether peroxynitrite, a reaction product of cigarette smoke, is involved in facilitated oxidation of LDL in smokers...
  64. ncbi Lipoperoxidation and hemodialysis
    Rosa Ramos
    Nephrology Department, Ciutat Sanitaria i Universitaria de Bellvitge, c Feixa Llarga s n, L Hospitalet del Llobregat, 08907 Barcelona, Spain
    Metabolism 57:1369-74. 2008
    ..b>Thiobarbituric acid reactive substances (TBARS) and lipoperoxides increased in patients after a year of hemodialysis, but the difference ..
  65. ncbi Oxidative DNA damage in rats exposed to extremely low frequency electro magnetic fields
    Beran Yokus
    Department of Biochemistry, Faculty of Veterinary, Dicle University, 21280 Diyarbakir, Turkey
    Free Radic Res 39:317-23. 2005
    ..97 mT) on 8OHdG levels in DNA and thiobarbituric acid reactive substances (TBARS) in plasma...
  66. ncbi Modulation of selenite cataract by the flavonoid fraction of Emilia sonchifolia in experimental animal models
    Y Lija
    Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala 695 581, India
    Phytother Res 20:1091-5. 2006
    ..The results suggest that flavonoids from ES can modulate lens opacification and oxidative stress in selenite-induced cataract...
  67. ncbi Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in rats
    Aluet Borrego
    Department of Biomedicine, Ozone Research Center, National Center for Scientific Research, P O Box 6414 Havana City, Cuba
    Mediators Inflamm 13:13-9. 2004
    ....
  68. ncbi Exhalation of H2O2 and thiobarbituric acid reactive substances (TBARs) by healthy subjects
    D Nowak
    Department of Physiology, Medical University of Lodz, Lodz, Poland
    Free Radic Biol Med 30:178-86. 2001
    ..Occasional detection of TBARs in EBC of never smoked persons may be a result of sufficient antioxidant activity in the airways that protects tissues from peroxidative damage...
  69. ncbi L-Carnitine protects plasma components against oxidative alterations
    Joanna Kolodziejczyk
    Department of General Biochemistry, University of Lodz, Lodz, Poland
    Nutrition 27:693-9. 2011
    ....
  70. ncbi Possible role of increased oxidant stress in multiple organ failure after systemic inflammatory response syndrome
    Takeshi Motoyama
    Division of Intensive and Critical Care Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto City, 860-8556 Japan
    Crit Care Med 31:1048-52. 2003
    ..1% vs. 15.8%, p <.001). CONCLUSIONS: It can be concluded that processes of oxidative stress in connection with continued SIRS may promote the development of MOF...
  71. ncbi Phenolic antioxidants attenuate hippocampal neuronal cell damage against kainic acid induced excitotoxicity
    M S Parihar
    Biochemistry Division, Faculty of Life Science, School of Studies in Zoology, Vikram University, Ujjain 456 010, India
    J Biosci 28:121-8. 2003
    ....
  72. ncbi Oxidized LDL induces an oxidative stress and activates the tumor suppressor p53 in MRC5 human fibroblasts
    C Maziere
    Laboratoire de Biochimie, Universite de Picardie Jules Verne, CHRU d Amiens, Place Victor Pauchet, Amiens Cedex 1, 80054, France
    Biochem Biophys Res Commun 276:718-23. 2000
    ..This effect might be related to the cytotoxic effect of OxLDL since the activation of p53 is known to lead to cell cycle arrest, necrosis or apoptosis...
  73. ncbi Effect of ethanolic extract of Embelia ribes on dyslipidemia in diabetic rats
    Uma Bhandari
    Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi, India
    Int J Exp Diabetes Res 3:159-62. 2002
    ..The results of test drug were comparable to gliclazide (25 mg/kg, orally), a standard antihyperglycemic agent. This is the first pilot study to provide biochemical evidence of potential of E. ribes in diabetic dyslipidemia...
  74. ncbi Influence of season and pollution on the antioxidant defenses of the cichlid fish acará (Geophagus brasiliensis)
    D Wilhelm Filho
    Departamento de Ecologia e Zoologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, 88040 900 Florianopolis, SC, Brazil
    Braz J Med Biol Res 34:719-26. 2001
    ..The higher antioxidant defenses found at the end of spring are probably related to the enhanced activities during high temperature periods in thermoconforming organisms...
  75. ncbi Oxidative preconditioning affords protection against carbon tetrachloride-induced glycogen depletion and oxidative stress in rats
    E Candelario-Jalil
    Center for Research and Biological Evaluation, University of Havana, Institute of Pharmacy and Food Sciences, Apartado Postal 6079, Havana City 10600, Cuba
    J Appl Toxicol 21:297-301. 2001
    ..Our results showed that ozone treatment, in our experimental conditions, was able to prevent anaerobic glycolysis and oxidative stress induced by CCl(4)...
  76. ncbi Decreased oxidative stress in patients with idiopathic dilated cardiomyopathy one year after immunoglobulin adsorption
    I Schimke
    Medizinische Klinik, Humboldt Universitat zu Berlin, Germany
    J Am Coll Cardiol 38:178-83. 2001
    ....
  77. ncbi Rats fed a high sucrose diet have altered heart antioxidant enzyme activity and gene expression
    Jérôme Busserolles
    Centre de Recherche en Nutrition Humaine d Auvergne, Unité des Maladies Métaboliques et Micronutriments, INRA, Theix, 63122 Saint Genes Champanelle, France
    Life Sci 71:1303-12. 2002
    ..These findings confirm the pro-oxidant effect of high sucrose feeding to rats and highlight the NO/O(2)(*-) balance importance in oxidative homeostasis...
  78. ncbi Effects of black tea extract on carbon tetrachloride-induced lipid peroxidation in liver, kidneys, and testes of rats
    Zaineb A Fadhel
    College of Pharmacy, University of Petra, P O Box 961343, Amman, Jordan
    Phytother Res 16:S28-32. 2002
    ..tea against carbon tetrachloride-induced lipid peroxidation as determined by the formation of thiobarbituric acid reactive substances in liver, kidneys and testes of rats. A 0...
  79. ncbi Antihyperglycaemic activity of Musa sapientum flowers: effect on lipid peroxidation in alloxan diabetic rats
    L Pari
    Department of Biochemistry, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India
    Phytother Res 14:136-8. 2000
    ..The decrease in thiobarbituric acid reactive substances (TBARS) and the increase in reduced glutathione (GSH), glutathione peroxidase (GSH-Px), ..
  80. ncbi Protective effects of lemon flavonoids on oxidative stress in diabetic rats
    Y Miyake
    Central Research Laboratory of Pokka Corporation, Ltd, Aichi, Japan
    Lipids 33:689-95. 1998
    ..Crude flavonoids, eriocitrin, and hesperidin suppressed the oxidative stress in the diabetic rats. These results demonstrated that dietary lemon flavonoids of eriocitrin and hesperidin play a role as antioxidant in vivo...
  81. ncbi Ameliorative effect of melatonin against gamma-irradiation-induced oxidative stress and tissue injury
    M A el-Missiry
    Zoology Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
    Ecotoxicol Environ Saf 66:278-86. 2007
    ..Moreover, melatonin shows a radioprotective impact against ionizing-radiation-induced oxidative stress and organ injury...
  82. ncbi Succinic acid monoethyl ester prevents oxidative stress in streptozotocin-nicotinamide-induced type2 diabetic rats
    Ramalingam Saravanan
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu - 608 002, India
    J Basic Clin Physiol Pharmacol 17:115-32. 2006
    ..Our result suggest that non glucidic nutrient, such as EMS as a potent antidiabetic, may optimalize antiperoxidative and antioxidants status by restoring the biochemical alterations found in STZ-nicotinamide-induced type 2 diabetes...
  83. ncbi Pongamia pinnata modulates the oxidant-antioxidant imbalance in ammonium chloride-induced hyperammonemic rats
    M Mohamed Essa
    Department of Biochemistry, Faculty of Sciences, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India
    Fundam Clin Pharmacol 20:299-303. 2006
    ..The exact mechanism has to be still investigated and isolation of active constituents is required...
  84. ncbi Citrulline and ammonia accumulating in citrullinemia reduces antioxidant capacity of rat brain in vitro
    Cristina C Prestes
    , , Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, CEP 90035-003, Porto Alegre, RS, Brazil
    Metab Brain Dis 21:63-74. 2006
    ..Taken together, these results may indicate that L-citrulline and ammonia decreased the antioxidant capacity of the brain, which may reflect a possible involvement of oxidative stress in the neuropathology of citrullinemia...
  85. ncbi Alpha-ketoglutarate modulates the circadian patterns of lipid peroxidation and antioxidant status during N-nitrosodiethylamine-induced hepatocarcinogenesis in rats
    K B Dakshayani
    Department of Biochemistry, Annamalai University, Annamalainagar, Tamil Nadu, India
    J Med Food 9:90-7. 2006
    ..It can be concluded that alpha-KG exerts its chemopreventive effect by restoring antioxidants and their circadian rhythms...
  86. ncbi The effect of Aegle marmelos fruit extract in streptozotocin diabetes: a histopathological study
    N Kamalakkannan
    Department of Biochemistry, Annamalai Nagar, Tamil Nadu, India
    J Herb Pharmacother 5:87-96. 2005
    ..The effects observed in the fruit extract treated animals were better those in animals treated with glibenclamide (300 microg/kg)...
  87. ncbi Supplementation of fenugreek leaves reduces oxidative stress in streptozotocin-induced diabetic rats
    B Annida
    Department of Biochemistry, Annamalai University, Annamalainagar, Tamil Nadu, India
    J Med Food 8:382-5. 2005
    ..Insulin restores all the parameters to near normal values. Thus, fenugreek leaf powder reduces oxidative stress in experimental diabetes...
  88. ncbi Effect of tetrahydrocurcumin on erythromycin estolate-induced lipid peroxidation in rats
    Pidaran Murugan
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India
    J Basic Clin Physiol Pharmacol 16:1-15. 2005
    ..The results of this study indicate that THC affords significant protection against EME-induced lipid peroxidation...
  89. ncbi Action of Hygrophila auriculata against streptozotocin-induced oxidative stress
    M Vijayakumar
    Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow 226 001, Uttar Pradesh, India
    J Ethnopharmacol 104:356-61. 2006
    ..HAEt, 100 and 250 mg/kg body weight) for 3 weeks showed significant reduction in blood glucose, thiobarbituric acid reactive substances (TBARS) and hydroperoxide in both liver and kidney...
  90. ncbi Influence of indole acetic acid on antioxidant levels and enzyme activities of glucose metabolism in rat liver
    Diogo Luiz Oliveira
    Department of Basic Science, Faculty of Zootechny and Food Engineering FZEA, University of Sao Paulo, Pirassununga, Brazil
    Cell Biochem Funct 25:195-201. 2007
    ..The effects of IAA were independent of the way of administration...
  91. ncbi Nephrotoxicity in rats induced by chlorpryfos-ethyl and ameliorating effects of antioxidants
    M Oncu
    Department of Histology and Embryology, School of Medicine, Suleyman Demirel University, Isparta, Turkey
    Hum Exp Toxicol 21:223-30. 2002
    ....
  92. ncbi Probing the anti-hyperlipidemic efficacy of the allspice (Pimenta officinalis Lindl.) in rats fed with high fat diet
    M P Shyamala
    Pharmacognosy Research Laboratory, School of Biosciences, Mahatma Gandhi University, Kottayam
    Indian J Physiol Pharmacol 49:363-8. 2005
    ..HFD caused oxidative stress in these animals as shown by marked increment in the levels of thiobarbituric acid reactive substances (TBARS) and diene conjugates (CD), and a distinct diminution in reduced glutathione (GSH) content ..
  93. ncbi Antioxidant role of Umbelliferone in STZ-diabetic rats
    B Ramesh
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamilnadu, India
    Life Sci 79:306-10. 2006
    ..Diabetic rats had an elevation in the levels of lipid peroxidation markers (thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (HP) and conjugated dienes (CD)), and a reduction in nonenzymic ..
  94. ncbi Oxidative stress and histopathological changes in the heart following oral lindane (gamma hexachlorohexane) administration in rats
    Roy Ananya
    Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India
    Med Sci Monit 11:BR325-9. 2005
    ..RESULTS: Lipid peroxidation of the heart, as measured by thiobarbituric acid reactive substances, (TBARS) was increased, with a decrease in GSH level...
  95. ncbi Promotion of oxidative stress by L-tryptophan in cerebral cortex of rats
    Luciane Rosa Feksa
    , , Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurochem Int 49:87-93. 2006
    ....
  96. ncbi Antioxidant effect of the marine algae Chlorella vulgaris against naphthalene-induced oxidative stress in the albino rats
    K Vijayavel
    Department of Pharmacology and Environmental Toxicology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, 600 113, Tamil Nadu, India
    Mol Cell Biochem 303:39-44. 2007
    ..The present results suggest that Chlorella vulgaris extract exerts its chemo-preventive effect by modulating the antioxidants status and lipid peroxidation during naphthalene intoxication...
  97. ncbi Immobilization stress in rat tissues: alterations in protein oxidation, lipid peroxidation and antioxidant defense system
    Emel Sahin
    Department of Biochemistry, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey
    Comp Biochem Physiol C Toxicol Pharmacol 144:342-7. 2007
    ..Our results showed that the response of antioxidant defense system to stress differs for each tissue, and protein oxidation and lipid peroxidation is induced by immobilization stress in peripheral tissues...
  98. ncbi A preliminary study of the levels of testis oxidative stress parameters after MK-801-induced experimental psychosis model: protective effects of CAPE
    Birsen Ozyurt
    Gaziosmanpasa University, Faculty of Medicine, Department of Anatomy, Tokat, Turkey
    Toxicology 230:83-9. 2007
    ..The results showed that experimentally induced schizophrenia caused oxidative stress in testes of rats and treatment with CAPE reduced these harmful effects...
  99. ncbi Effect of ellagic acid on cyclosporine A-induced oxidative damage in the liver of rats
    Leelavinothan Pari
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamilnadu, India
    Fundam Clin Pharmacol 22:395-401. 2008
    ..and lactate dehydrogenase with a significant elevation of lipid peroxidation markers such as thiobarbituric acid reactive substances (TBARS) and hydroperoxides in the liver...
  100. ncbi Tyrosine promotes oxidative stress in cerebral cortex of young rats
    Angela M Sgaravatti
    Programa de Pós Graduação em Ciências Biológicas Bioquímica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Int J Dev Neurosci 26:551-9. 2008
    ..This suggests that oxidative stress may represent a pathophysiological mechanism in tyrosinemic patients, in which this amino acid accumulates...
  101. ncbi Protective effects of dietary ginger (Zingiber officinales Rosc.) on lindane-induced oxidative stress in rats
    Rafat S Ahmed
    Environmental Biochemistry Laboratory, Department of Biochemistry, University College of Medical Sciences and G T B Hospital, University of Delhi, Dilshad Garden, Delhi 110095, India
    Phytother Res 22:902-6. 2008
    ..These findings suggest that a diet containing naturally occurring compounds is effective in exerting protective effects by modulating oxidative stress...

Research Grants65

  1. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank Anania; Fiscal Year: 2009
    ..including weight loss, improved hepatic histology and loss of hepatic steatosis, and reduced thiobarbituric acid reactive substances (TEARS), a surrogate marker of oxidative stress...
  2. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank A Anania; Fiscal Year: 2010
    ..including weight loss, improved hepatic histology and loss of hepatic steatosis, and reduced thiobarbituric acid reactive substances (TEARS), a surrogate marker of oxidative stress...
  3. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank Anania; Fiscal Year: 2007
    ..including weight loss, improved hepatic histology and loss of hepatic steatosis, and reduced thiobarbituric acid reactive substances (TEARS), a surrogate marker of oxidative stress...
  4. Ambient Air Pollution, Preeclampsia, and Preterm Delivery
    Michelle Williams; Fiscal Year: 2007
    ..Additionally, we will test biological markers of maternal lipid peroxidation (thiobarbituric acid reactive substances) and inflammation (high sensitivity C-reactive protein) in maternal blood samples drawn during ..
  5. Ambient Air Pollution, Preeclampsia/Preterm Delivery
    CAROLE RUDRA; Fiscal Year: 2006
    ..Additionally, we will test biological markers of maternal lipid peroxidation (thiobarbituric acid reactive substances) and inflammation (high sensitivity C-reactive protein) in maternal blood samples drawn during ..
  6. Novel Antioxidant Mechanisms of Surfactant Proteins
    Francis McCormack; Fiscal Year: 2006
    ..Both proteins block accumulation of thiobarbituric acid reactive substances (TBARS) and conjugated dienes during metal-induced oxidation of surfactant phospholipids or low ..
  7. Point-of-Care Measurement of Glycated Hemoglobin
    MARGO COHEN; Fiscal Year: 2004
    ....
  8. Glycemic Control and Progression of Diabetic Retinopathy
    Renu A Kowluru; Fiscal Year: 2010
    ....
  9. Role of Ras in Retinal Cell Death in Diabetes
    Renu A Kowluru; Fiscal Year: 2010
    ..The results are expected to elucidate new insight into the pathogenesis of diabetic retinopathy, and reveal novel targets for therapies to prevent the development and progression of retinopathy. ..
  10. Glycemic Control and Progression of Diabetic Retinopathy
    Renu A Kowluru; Fiscal Year: 2010
    ....
  11. Role of Ras in Retinal Cell Death in Diabetes
    Renu Kowluru; Fiscal Year: 2009
    ..The results are expected to elucidate new insight into the pathogenesis of diabetic retinopathy, and reveal novel targets for therapies to prevent the development and progression of retinopathy. ..
  12. Glycemic Control and Progression of Diabetic Retinopathy
    Renu Kowluru; Fiscal Year: 2009
    ....
  13. LDL Modification in Diabetic Complications
    MARGO COHEN; Fiscal Year: 2007
    ..This Phase II SBIR project will advance to the clinical stage a novel compound that prevents modifications of lipoproteins that occur in diabetes and that contribute to the development of these complications. ..
  14. Glycemic Control and Progression of Diabetic Retinopathy
    Renu Kowluru; Fiscal Year: 2007
    ....
  15. Reducing Renal TGF-B in Diabetic Glomerulosclerosis
    MARGO COHEN; Fiscal Year: 2005
    ..abstract_text> ..
  16. Role of Ras in Retinal Cell Death in Diabetes
    Renu Kowluru; Fiscal Year: 2006
    ....
  17. Long Term Toxicity of Di- and Tri-Chloroacetate
    Ezdihar Hassoun; Fiscal Year: 2007
    ..These can be used as basis to determine similar indicators for human risks from exposure to the compounds in the drinking water, and also to adjust the allowable amounts of the compounds in the drinking water. ..
  18. Cardioprotective Efficacy ofMg-Supplementation during HAART Therapy
    IVAN TONG MAK; Fiscal Year: 2010
    ....
  19. Protective Efficacy of Mg-Supplementation Against NRTI-induced Cardiac Toxicity
    IVAN MAK; Fiscal Year: 2007
    ..This proposed exploratory effort may reveal a potential usefulness of Mg-supplements as an effective, yet relatively inexpensive adjunct therapy to lessen NRTI-related cardiovascular toxicity. ..
  20. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  21. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 1992
    ....
  22. DRUGS AND DEVELOPMENT OF ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 1980
    ....
  23. ENHANCEMENT OF CORONARY CONSTRICTION BY COMBUSTION-SOURCE AIR TOXICS
    Matthew J Campen; Fiscal Year: 2010
    ..Results from these studies will assist in the assessment and management of personal risk of health effects from air pollution exposure. ..
  24. ENHANCEMENT OF CORONARY CONSTRICTION BY COMBUSTION-SOURCE AIR TOXICS
    Matthew J Campen; Fiscal Year: 2009
    ..Results from these studies will assist in the assessment and management of personal risk of health effects from air pollution exposure. ..
  25. ENHANCEMENT OF CORONARY CONSTRICTION BY COMBUSTION-SOURCE AIR TOXICS
    Matthew Campen; Fiscal Year: 2009
    ..Results from these studies will assist in the assessment and management of personal risk of health effects from air pollution exposure. ..