Summary: The dialdehyde of malonic acid.

Top Publications

  1. ncbi Complement factor H binds malondialdehyde epitopes and protects from oxidative stress
    David Weismann
    Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
    Nature 478:76-81. 2011
  2. pmc Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans
    Meng Yun Chou
    Department of Medicine, UCSD, La Jolla, California 92093, USA
    J Clin Invest 119:1335-49. 2009
  3. ncbi Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors
    F Nielsen
    Institute of Community Health, Odense University, Denmark
    Clin Chem 43:1209-14. 1997
  4. ncbi A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress
    Daniele Del Rio
    Human Nutrition Unit, Department of Public Health, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Nutr Metab Cardiovasc Dis 15:316-28. 2005
  5. pmc IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis
    Christoph J Binder
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
    J Clin Invest 114:427-37. 2004
  6. ncbi Potential markers of oxidative stress in stroke
    Antonio Cherubini
    Institute of Gerontology and Geriatrics, University of Perugia Medical School, Policlinico Monteluce Pad E, Via Brunamonti 51, 06122 Perugia, Italy
    Free Radic Biol Med 39:841-52. 2005
  7. ncbi The activities of liver adenosine deaminase, xanthine oxidase, catalase, superoxide dismutase enzymes and the levels of malondialdehyde and nitric oxide after cisplatin toxicity in rats: protective effect of caffeic acid phenethyl ester
    H Ramazan Yilmaz
    Department of Medical Biology and Genetics, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
    Toxicol Ind Health 21:67-73. 2005
  8. ncbi Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Circulation 98:1487-94. 1998
  9. ncbi Rapid fluorimetric method to detect total plasma malondialdehyde with mild derivatization conditions
    Daniele Del Rio
    Human Nutrition Unit, Department of Public Health, University of Parma, Via Volturno 39, Italy
    Clin Chem 49:690-2. 2003
  10. ncbi Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin
    F Fulia
    Division of Neonatal Care, School of Medicine, University of Messina, Italy
    J Pineal Res 31:343-9. 2001

Detail Information

Publications370 found, 100 shown here

  1. ncbi Complement factor H binds malondialdehyde epitopes and protects from oxidative stress
    David Weismann
    Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
    Nature 478:76-81. 2011
    ..AMD is the leading cause of blindness in Western societies, but its aetiology remains largely unknown. Malondialdehyde (MDA) is a common lipid peroxidation product that accumulates in many pathophysiological processes, including ..
  2. pmc Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans
    Meng Yun Chou
    Department of Medicine, UCSD, La Jolla, California 92093, USA
    J Clin Invest 119:1335-49. 2009
    ..These findings provide novel insights into the functions of NAbs in mediating host homeostasis and into their roles in health and diseases, such as chronic inflammatory diseases and atherosclerosis...
  3. ncbi Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors
    F Nielsen
    Institute of Community Health, Odense University, Denmark
    Clin Chem 43:1209-14. 1997
    b>Malondialdehyde (MDA) is one of the most frequently used indicators of lipid peroxidation. To generate reliable reference intervals for plasma malondialdehyde (P-MDA), a reference sample group was established in Funen, Denmark...
  4. ncbi A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress
    Daniele Del Rio
    Human Nutrition Unit, Department of Public Health, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Nutr Metab Cardiovasc Dis 15:316-28. 2005
    ..Lipid oxidation gives rise to a number of secondary products. Malondialdehyde (MDA) is the principal and most studied product of polyunsaturated fatty acid peroxidation...
  5. pmc IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis
    Christoph J Binder
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
    J Clin Invest 114:427-37. 2004
    During atherogenesis, LDL is oxidized, generating various oxidation-specific neoepitopes, such as malondialdehyde-modified (MDA-modified) LDL (MDA-LDL) or the phosphorylcholine (PC) headgroup of oxidized phospholipids (OxPLs)...
  6. ncbi Potential markers of oxidative stress in stroke
    Antonio Cherubini
    Institute of Gerontology and Geriatrics, University of Perugia Medical School, Policlinico Monteluce Pad E, Via Brunamonti 51, 06122 Perugia, Italy
    Free Radic Biol Med 39:841-52. 2005
    ..Among lipid peroxidation products, malondialdehyde, despite its relevant methodological limitations, is correlated with the size of ischemic stroke and clinical ..
  7. ncbi The activities of liver adenosine deaminase, xanthine oxidase, catalase, superoxide dismutase enzymes and the levels of malondialdehyde and nitric oxide after cisplatin toxicity in rats: protective effect of caffeic acid phenethyl ester
    H Ramazan Yilmaz
    Department of Medical Biology and Genetics, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
    Toxicol Ind Health 21:67-73. 2005
    ..adenosine deaminase (AD), xanthine oxidase (XO), catalase (CAT), superoxide dismutase (SOD) activities and malondialdehyde (MDA) and nitric oxide (NO) levels in liver tissue of rats...
  8. ncbi Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Circulation 98:1487-94. 1998
    ..Therefore, the association between plasma levels of oxidized LDL and malondialdehyde (MDA)-modified LDL and acute coronary syndromes and stable CAD was investigated.
  9. ncbi Rapid fluorimetric method to detect total plasma malondialdehyde with mild derivatization conditions
    Daniele Del Rio
    Human Nutrition Unit, Department of Public Health, University of Parma, Via Volturno 39, Italy
    Clin Chem 49:690-2. 2003
  10. ncbi Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin
    F Fulia
    Division of Neonatal Care, School of Medicine, University of Messina, Italy
    J Pineal Res 31:343-9. 2001
    ..This study measured a product of lipid peroxidation, malondialdehyde, and the nitrite/nitrate levels in the serum of 20 asphyxiated newborns before and after treatment with the ..
  11. ncbi Lipid peroxidation-DNA damage by malondialdehyde
    L J Marnett
    A B Hancock Jr Memorial Laboratory for Cancer Research Center in Molecular Toxicology, Vanderbilt Cancer Center, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville TN 37232, USA
    Mutat Res 424:83-95. 1999
    b>Malondialdehyde is a naturally occurring product of lipid peroxidation and prostaglandin biosynthesis that is mutagenic and carcinogenic. It reacts with DNA to form adducts to deoxyguanosine and deoxyadenosine...
  12. ncbi The activities of antioxidant enzymes and the level of malondialdehyde in cerebellum of rats subjected to methotrexate: protective effect of caffeic acid phenethyl ester
    Ertugrul Uzar
    School of Medicine Department of Neurology, Suleyman Demirel University, Isparta, Turkey
    Mol Cell Biochem 291:63-8. 2006
    ..CAPE was administered i.p. with a dose of 10 micromol kg(-1) day(-1) for 7 days. Malondialdehyde (MDA) levels and activities of superoxide dismutase (SOD) and catalase (CAT) were determined in cerebellar ..
  13. ncbi Specific recognition of malondialdehyde and malondialdehyde acetaldehyde adducts on oxidized LDL and apoptotic cells by complement anaphylatoxin C3a
    Marja Veneskoski
    Institute of Diagnostics, Department of Medical Microbiology and Immunology, University of Oulu, 90014 Oulu, Finland
    Free Radic Biol Med 51:834-43. 2011
    ..Recombinant human C3a bound specifically to low-density lipoprotein and bovine serum albumin modified with malondialdehyde (MDA) and malondialdehyde acetaldehyde (MAA) in chemiluminescence immunoassays...
  14. ncbi Lipid peroxidation, some extracellular antioxidants, and antioxidant enzymes in serum of patients with rheumatoid arthritis
    S Taysi
    Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey
    Rheumatol Int 21:200-4. 2002
    ..Serum malondialdehyde and ceruloplasmin levels and the activity of CuZn superoxide dismutase were higher, while transferrin levels ..
  15. ncbi Oxidative status and malondialdehyde in beta-thalassaemia patients
    Giuliana Cighetti
    Department of Medical Chemistry and Biochemistry, Ospedale Maggiore IRCCS, Faculty of Medicine, University of Milan, Via Saldini 50, 20133 Milan, Italy
    Eur J Clin Invest 32:55-60. 2002
    ..The aim of this study was to detect and correlate iron overload parameters with the oxidative stress and the antioxidant capability in beta-thalassaemia patients...
  16. ncbi Plasma carotenoid and malondialdehyde levels in ischemic stroke patients: relationship to early outcome
    M Cristina Polidori
    Institute of Physiological Chemistry I, Heinrich Heine University, Dusseldorf, Germany
    Free Radic Res 36:265-8. 2002
    ..levels of six carotenoids, which are lipophilic micronutrients with antioxidant properties, as well as of malondialdehyde (MDA), a marker of lipid peroxidation, was followed in ischemic stroke patients...
  17. ncbi Microsporidia parasites disrupt the responses to cadmium exposure in a gammarid
    Eric Gismondi
    Laboratoire des Interactions Ecotoxicologie Biodiversité Ecosystèmes LIEBE, Universite Paul Verlaine Metz, CNRS UMR 7146, Campus Bridoux, Avenue du général Delestraint, 57070 Metz, France
    Environ Pollut 160:17-23. 2012
    ..Moreover, higher malondialdehyde levels detected in infected females revealed that they suffered more cellular damages...
  18. ncbi Malondialdehyde as biomarker of oxidative damage to lipids caused by smoking
    Jens Lykkesfeldt
    Section of Biomedicine, Department of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, 9 Ridebanevej, DK 1870 Frederiksberg C, Denmark
    Clin Chim Acta 380:50-8. 2007
    Thiobarbituric acid reactive substances (TBARS) and malondialdehyde (MDA) have been used as biomarkers of lipid oxidation for more than thirty years...
  19. ncbi Protective effects of DIDS against ethanol-induced gastric mucosal injury in rats
    Wei Zhao
    Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Institutes of Medical Sciences, Department of Pathology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Acta Biochim Biophys Sin (Shanghai) 41:301-8. 2009
    ..Our results suggested that DIDS is beneficial in rat model of gastric injury through mechanisms that involve inhibiting inflammatory cell infiltration and lipid peroxidation and up-regulating the COX-2/PGE2 pathway...
  20. ncbi Minocycline protects against myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats
    Xiaorong Hu
    Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuhan, China
    Eur J Pharmacol 638:84-9. 2010
    ..The present study suggested that minocycline could protect against myocardial ischemia and reperfusion injury by inhibiting HMGB1 expression...
  21. ncbi A diet rich in dietary fiber from cocoa improves lipid profile and reduces malondialdehyde in hypercholesterolemic rats
    Elena Lecumberri
    Department of Metabolism and Nutrition, Instituto del Frio CSIC, Madrid, Spain
    Nutrition 23:332-41. 2007
    ..The potential hypolipidemic effect of a new cocoa product rich in dietary fiber (DF) naturally containing antioxidant polyphenols (cocoa fiber [CF]) was studied in a rat model of dietary-induced hypercholesterolemia...
  22. ncbi The change of oxidative stress products in diabetes mellitus and diabetic retinopathy
    Hong Zhi Pan
    First Affiliated Hospital of the Harbin Medical University, No 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China
    Br J Ophthalmol 92:548-51. 2008
    ..The aim of this study is to detect oxidative stress parameters in type 2 diabetes mellitus with or without retinopathy and to investigate the relationship between oxidative stress and patients with type 2 diabetic retinopathy...
  23. ncbi Gramine-induced growth inhibition, oxidative damage and antioxidant responses in freshwater cyanobacterium Microcystis aeruginosa
    Yu Hong
    Institute of Environmental Biology, Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, PR China
    Aquat Toxicol 91:262-9. 2009
    ..The lipid-peroxidation product malondialdehyde (MDA) increased significantly in gramine-treated cells...
  24. ncbi The analog of Ginkgo biloba extract 761 is a protective factor of cognitive impairment induced by chronic fluorosis
    Caiyi Zhang
    Department of Neurology, Xuzhou Medical College Affiliated Hospital, Huaihai Road No 99, Xuzhou, Jiangsu Province 221000, China
    Biol Trace Elem Res 153:229-36. 2013
    ..Superoxide dismutase (SOD) activity and the levels of glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) were measured...
  25. ncbi Enhanced chilling tolerance at the booting stage in rice by transgenic overexpression of the ascorbate peroxidase gene, OsAPXa
    Yutaka Sato
    National Agricultural Research Center for Hokkaido Region, Hitsujigaoka 1, Toyohira, Sapporo 062 8555, Japan
    Plant Cell Rep 30:399-406. 2011
    ..activity on the levels of H(2)O(2) and lipid peroxidation were determined by measuring H(2)O(2) levels and malondialdehyde (MDA) contents in spikelets during cold treatments at the booting stage...
  26. ncbi Volatile anesthetic preconditioning attenuated sepsis induced lung inflammation
    Nurdan Bedirli
    Department of Anaesthesiology, Gazi University, Ankara, Turkey
    J Surg Res 178:e17-23. 2012
    ..This study aimed to evaluate the differential protective effects of isoflurane or sevoflurane on lung inflammation in a rat model of cecal ligation and puncture (CLP) induced sepsis...
  27. ncbi Antioxidant enzyme and malondialdehyde levels in patients with panic disorder
    Murat Kuloglu
    Department of Psychiatry, Medical Faculty, Firat University, Elazig, Turkey
    Neuropsychobiology 46:186-9. 2002
    ..some antioxidant enzymes [glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT)] and malondialdehyde (MDA), a product of lipid peroxidation, were associated with panic disorder (PD)...
  28. ncbi Glutathione promotes prostaglandin H synthase (cyclooxygenase)-dependent formation of malondialdehyde and 15(S)-8-iso-prostaglandin F2α
    Dimitrios Tsikas
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    FEBS Lett 586:3723-30. 2012
    ..Here, we report that GSH promotes concomitant formation of the current oxidative stress biomarkers malondialdehyde (MDA) and 15(S)-8-iso-prostaglandin F(2α) from AA via PGHS...
  29. ncbi Mechanism of protective effects of Danshen against iron overload-induced injury in mice
    Yonggang Gao
    Department of Pharmacology, School of Basic Medicine, Hebei Medical University, 326, Xinshi South Road, Shijiazhuang, 050091 Hebei, China
    J Ethnopharmacol 145:254-60. 2013
    ..Danshen (Salvia miltiorrhiza) has been widely prescribed in traditional folk medicine for treatment of hepatic and cardiovascular diseases in China and other Asian countries for several hundred years...
  30. ncbi Diaminonaphtalene, a new highly specific reagent for HPLC-UV measurement of total and free malondialdehyde in human plasma or serum
    J P Steghens
    Biochemistry Laboratory C, Edouard Herriot Hospital, Lyon, France
    Free Radic Biol Med 31:242-9. 2001
    We describe a new method to measure free and total malondialdehyde (MDA) in human plasma or serum, which is based on the derivatization of MDA with diaminonaphtalene (DAN) in an acidic medium at 37 degrees C...
  31. ncbi Increased plasma malondialdehyde and protein carbonyl levels and lymphocyte DNA damage in patients with angiographically defined coronary artery disease
    Umit Mutlu-Turkoglu
    Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, 34093 Capa Istanbul, Turkey
    Clin Biochem 38:1059-65. 2005
    ..b>Malondialdehyde (MDA) and protein carbonyl (PC) levels, as well as ferric reducing antioxidant power (FRAP), were measured in ..
  32. ncbi Potential hepatoprotective effects of fullerenol C60(OH)24 in doxorubicin-induced hepatotoxicity in rats with mammary carcinomas
    Rade Injac
    Faculty of Pharmacy, The Chair of Pharmaceutical Biology, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    Biomaterials 29:3451-60. 2008
    ..lactate dehydrogenase (LDH) and alpha-hydroxybutyrate dehydrogenase (alpha-HBDH), as well as in the levels of malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GSH-Px), total antioxidant status (TAS), glutathione ..
  33. ncbi Anti-oxidative effect of apocynin on insulin resistance in high-fat diet mice
    Ran Meng
    Department of Endocrinology, Nanjing Drum Tower Hospital, Nanjing University School of Medicine, 321 Zhongshan Road, Nanjing, 210008, China
    Ann Clin Lab Sci 41:236-43. 2011
    ..Compared to the HFD control mice, serum malondialdehyde (MDA) was significantly lower and serum superoxide dismutase (SOD) was significantly higher in apocynin ..
  34. ncbi Number of endothelial progenitor cells in peripheral artery disease as a marker of severity and association with pentraxin-3, malondialdehyde-modified low-density lipoprotein and membrane type-1 matrix metalloproteinase
    Tetsuji Morishita
    Department of Cardiovascular Medicine, University of Fukui Hospital, Matsuoka, Fukui, Japan
    J Atheroscler Thromb 19:149-58. 2012
    ..Despite the occurrence of endothelial dysfunction in peripheral artery disease (PAD), few data are available on EPC mobilization in this setting...
  35. pmc Modification in oxidative stress, inflammation, and lipoprotein assembly in response to hepatocyte nuclear factor 4alpha knockdown in intestinal epithelial cells
    Valérie Marcil
    Research Institute, McGill University, Campus MGH, C10 148 6, Montreal H3G 1A4, Quebec
    J Biol Chem 285:40448-60. 2010
    ..Caco-2 cells resulted in the following: (a) an increase in oxidative stress as demonstrated by the levels of malondialdehyde and conjugated dienes; (b) a reduction in secondary endogenous antioxidants (catalase, glutathione peroxidase,..
  36. ncbi Beneficial effects of THSG on acetic acid-induced experimental colitis: involvement of upregulation of PPAR-γ and inhibition of the Nf-Κb inflammatory pathway
    Cheng Zeng
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Molecules 16:8552-68. 2011
    ..THSG apparently decreased the increase of malondialdehyde (MDA) which is a marker of lipid peroxidation...
  37. pmc Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway
    Baohai Shao
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 285:18473-84. 2010
    ..We therefore determined whether carbonyls resulting from lipid peroxidation (malondialdehyde (MDA) and hydroxynonenal) or carbohydrate oxidation (glycolaldehyde, glyoxal, and methylglyoxal) covalently ..
  38. ncbi Effects of extremely low-frequency magnetic field on caspase activities and oxidative stress values in rat brain
    Mehmet Zulkuf Akdag
    Department of Biophysics, Medical School of Dicle University, 21280 Diyarbakir, Turkey
    Biol Trace Elem Res 138:238-49. 2010
    ..In addition, the levels of catalase (CAT), malondialdehyde (MDA), myeloperoxidase (MPO), total antioxidative capacity (TAC), total oxidant status (TOS), and oxidative ..
  39. ncbi Total antioxidant capacity, hydrogen peroxide, malondialdehyde and total nitric oxide concentrations in patients with severe persistent allergic asthma: its relation to omalizumab treatment
    Arzu Didem Yalcin
    Allergology and Clinical Immunology Unit, Antalya Education and Research Hospital, Antalya, Turkey
    Clin Lab 58:89-96. 2012
    ..However, there is no data available to evaluate the alterations in total antioxidant capacity, hydrogen peroxide, malondialdehyde, and total nitric oxide concentrations.
  40. ncbi Reactions of N-methyl-2-phenylindole with malondialdehyde and 4-hydroxyalkenals. Mechanistic aspects of the colorimetric assay of lipid peroxidation
    I Erdelmeier
    Centre de Recherche Oxis International S A, 94385 Bonneuil sur Marne, France
    Chem Res Toxicol 11:1184-94. 1998
    Under specific acidic conditions, both malondialdehyde (1, MDA) and 4-hydroxynonenal (2, 4-HNE) react with N-methyl-2-phenylindole (3) to give the same chromophoric cyanine 4 with maximal absorbance at 586 nm...
  41. ncbi Prevention of ischemia-reperfusion injury in rat ovarian tissue with the on-off method
    M Ingec
    Ataturk University, Medical Faculty, Department of Obstetrics and Gynecology, Erzurum, Turkiye
    J Physiol Pharmacol 62:575-82. 2011
    ..Similarly the damage indicators (malondialdehyde, DNA damage level and histopathological damage grade) were the lowest in ischemia/controlled reperfusion ..
  42. pmc Distinctive photosystem II photoinactivation and protein dynamics in marine diatoms
    Hongyan Wu
    Biology Department, Mount Allison University, Sackville, New Brunswick E4L1G7, Canada
    Plant Physiol 156:2184-95. 2011
  43. ncbi Effects of astaxanthin on oxidative stress in overweight and obese adults
    Hye Duck Choi
    College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, San 56 1, Sillim dong, Gwanak Gu, Seoul, 151 742, South Korea
    Phytother Res 25:1813-8. 2011
    ..b>Malondialdehyde (MDA), isoprostane (ISP), superoxide dismutase (SOD) and total antioxidant capacity (TAC), as oxidative ..
  44. ncbi Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice
    Kazufumi Nagata
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Nakahara ku, Kawasaki, Japan
    Neuropsychopharmacology 34:501-8. 2009
    ..Chronic physical restraint stress to mice enhanced levels of oxidative stress markers, malondialdehyde and 4-hydroxy-2-nonenal, in the brain, and impaired learning and memory, as judged by three different methods:..
  45. ncbi Green tea extract decreases oxidative stress and improves insulin sensitivity in an animal model of insulin resistance, the fructose-fed rat
    Isabelle Hininger-Favier
    INSERM, U884, Grenoble, F 38000, France
    J Am Coll Nutr 28:355-61. 2009
    ..Tea polyphenols, as both insulin potentiating factors and antioxidants, are postulated to act in preventing the metabolic syndrome, which is characterized by insulin resistance, dyslipidemia, and increased oxidative stress...
  46. ncbi Establishment of the mimetic aging effect in mice caused by D-galactose
    Shih Ching Ho
    Traditional Chinese Medicine Division, Development Center for Biotechnology, 81 Chang Hsing Street, Taipei, Taiwan, ROC
    Biogerontology 4:15-8. 2003
    ..After 45 days, mice treated with D-galactose showed a significant increase in the malondialdehyde (MDA), total antioxidant status (TAS) and a decrease in superoxide dismutase (SOD) in the blood compared with ..
  47. ncbi Effect of oral administration of Arabic gum on cisplatin-induced nephrotoxicity in rats
    Abdulhakeem A Al-Majed
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia
    J Biochem Mol Toxicol 17:146-53. 2003
    ..These findings suggest that lipid peroxidation is not the main cause of CP-induced nephrotoxicity but it is rather more dependent on other factors such as platinum disposition in renal interstitial tubules...
  48. ncbi Protective role of selenium against renal toxicity induced by cadmium in rats
    A S el-Sharaky
    Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt
    Toxicology 235:185-93. 2007
    ..a day [corrected] The results showed that cadmium treatment increased renal lipid peroxidation (measured as malondialdehyde, MDA) which was associated with a significant decrease in the antioxidant systems such as reduced glutathione ..
  49. ncbi Modulation of endometrial redox balance during the menstrual cycle: relation with sex hormones
    G Serviddio
    Department of Internal and Public Medicine, University of Bari, Piazza G Cesare 11, 70124 Bari, Italy
    J Clin Endocrinol Metab 87:2843-8. 2002
    ..On the endometrial specimens, total glutathione (GSH), oxidized GSH (GSSG), malondialdehyde, and GSH peroxidase activity (GSH-Px) were determined...
  50. ncbi Palmatine from Coptidis rhizoma reduces ischemia-reperfusion-mediated acute myocardial injury in the rat
    Young Min Kim
    Department of Pharmacology, School of Medicine, and Institute of Health Sciences, Gyeongsang National University, 92 Chilamdong, Jinju, Republic of Korea
    Food Chem Toxicol 47:2097-102. 2009
    ..We concluded that palmatine protects hearts from I/R injury in rats possibly by reducing oxidative stress and modulating inflammatory mediators...
  51. ncbi Protective effect of N-acetylcysteine on renal ischemia/reperfusion injury in the rat
    A Ozer Sehirli
    Marmara University, School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    J Nephrol 16:75-80. 2003
    ..Oxygen free radicals are important components involved in the pathophysiological tissue alterations observed during ischemia/reperfusion (I/R)...
  52. ncbi Validation of a novel ELISA for measurement of MDA-LDL in human plasma
    Ruth J Bevan
    Department of Clinical Biochemistry, University of Leicester, Leicester, UK
    Free Radic Biol Med 35:517-27. 2003
    ..We have produced two antibodies, recognizing the lipid oxidation product malondialdehyde (MDA) on whole LDL or ApoB-100...
  53. ncbi Hypoxic postconditioning reduces cardiomyocyte loss by inhibiting ROS generation and intracellular Ca2+ overload
    He Ying Sun
    Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St NE, Atlanta, GA 30308 2225, USA
    Am J Physiol Heart Circ Physiol 288:H1900-8. 2005
    ..of hydrogen peroxide) was significantly augmented after immediate reoxygenation as was the production of malondialdehyde, a product of lipid peroxidation...
  54. ncbi Caffeic acid phenethyl ester exerts a neuroprotective effect on CNS against pentylenetetrazol-induced seizures in mice
    Atilla Ilhan
    Inonu University Medical Faculty, Department of Neurology, Turgut Ozal Medical Center, Malatya, Turkey
    Neurochem Res 29:2287-92. 2004
    ..Our results demonstrate that CAPE treatment which prevents free radical production and ameliorates seizure severity may be useful at least as an adjunctive treatment of seizure disorders...
  55. ncbi Propofol pretreatment reduces ceramide production and attenuates intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion in rats
    Ke Xuan Liu
    Department of Anesthesiology, The First Affiliated Hospital, Sun Yat Sen University, No 58, Zhongshan 2th Rd, Guangzhou, China, 510080
    Anesth Analg 107:1884-91. 2008
    ..We investigated if pretreatment with propofol, an anesthetic with antioxidant properties, could reduce ceramide production, and consequently, mucosal epithelial apoptosis induced by II/R in rats...
  56. ncbi Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events
    Sotirios Tsimikas
    Division of Cardiovascular Diseases, University of California, San Diego, CA, USA
    J Lipid Res 48:425-33. 2007
    ..IgM and IgG OxLDL autoantibodies to malondialdehyde (MDA)-modified LDL, copper oxidized low density lipoprotein (CuOxLDL), and oxidized cholesterol linoleate (..
  57. ncbi Oxidative stress in Rett syndrome
    C Sierra
    Laboratory Department, , University of Barcelona, Barcelona, Spain
    Brain Dev 23:S236-9. 2001
    ..activities (superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase) and plasma malondialdehyde, as lipid peroxidation marker in a group of patients with Rett syndrome...
  58. ncbi Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease
    Massimo Corradi
    National Institute of Occupational Safety and Prevention Research Center, Laboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Italy
    Am J Respir Crit Care Med 167:1380-6. 2003
    ..Aldehydes (malondialdehyde, hexanal, heptanal, and nonanal) were measured by liquid chromatography-tandem mass spectrometry in all ..
  59. ncbi Allelopathic mechanism of pyrogallol to Microcystis aeruginosa PCC7806 (Cyanobacteria): from views of gene expression and antioxidant system
    Jihai Shao
    Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, PR China
    Chemosphere 75:924-8. 2009
    ..It was concluded that oxidant damage is an important mechanism for the allelopathic effect of pyrogallol on M. aeruginosa...
  60. ncbi Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats
    Fei Yan
    Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, China
    Phytomedicine 16:805-13. 2009
    ..In the liver, significantly elevated levels (p<0.001) of malondialdehyde (MDA), lowered levels of reduced glutathione (GSH) (p<0.05) and catalase (CAT) (p<0...
  61. ncbi Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins
    Sihem Boudina
    Division of Endocrinology, Metabolism, and Diabetes, Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Diabetes 56:2457-66. 2007
    ..Mitochondrial uncoupling has been proposed to contribute to these metabolic abnormalities but has not been directly demonstrated...
  62. pmc Strawberry polyphenols attenuate ethanol-induced gastric lesions in rats by activation of antioxidant enzymes and attenuation of MDA increase
    Jose M Alvarez-Suarez
    Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche Sez Biochimica, Facolta di Medicina, Universita Politecnica delle Marche, Ancona, Italy
    PLoS ONE 6:e25878. 2011
  63. ncbi The role of prednisolone and epinephrine on gastric tissue and erythrocyte antioxidant status in adrenalectomized rats
    A Yildirim
    Department of Biochemistry, Ataturk University, Medical Faculty, Erzurum, Turkey
    J Physiol Pharmacol 58:105-16. 2007
    ..This study evaluated whether there was an effect of adrenalectomy on lipid peroxidation [malondialdehyde (MDA)] and antioxidant [superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione (GSH) levels]..
  64. ncbi Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer
    Jia Wang
    School of Life Sciences, Northeast Normal University, Changchun, PR China
    J Ethnopharmacol 130:421-3. 2010
  65. ncbi Protective role of carnitine ester against radiation-induced oxidative stress in rats
    Heba H Mansour
    Health Radiation Research Department, National Center for Radiation Research and Technology, P O Box 29, Nasr City, Cairo, Egypt
    Pharmacol Res 54:165-71. 2006
    ..Also, ALC resulted in a significant decrease in total nitrate/nitrite (NO(x)) and malondialdehyde (MDA) levels in both lung and liver tissues and a significant decrease in triglycerides, low-density ..
  66. ncbi Breath markers and soluble lipid peroxidation markers in critically ill patients
    Joachim Scholpp
    Department of Anaesthesia, University Hospital of Freiburg, Germany
    Clin Chem Lab Med 40:587-94. 2002
    ..Additionally, patients were assessed according to their inflammatory status. Concentrations of malondialdehyde and thiobarbituric acid-reactive substances in plasma as well as pentane concentrations in breath increased ..
  67. ncbi Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats
    H Parlakpinar
    Department of Pharmacology, Faculty of Medicine, Inonu University, 44280 Malatya, Turkey
    Toxicology 207:169-77. 2005
    ..We investigated the effects of CAPE on GEN-induced changes in renal malondialdehyde (MDA), a lipid peroxidation product, nitric oxide (NO) generation, superoxide dismutase (SOD), catalase (CAT) ..
  68. ncbi Increased glomerular and extracellular malondialdehyde levels in patients and rats with focal segmental glomerulosclerosis
    H T Kuo
    Kaohsiung Medical University, Kaohsiung, Taiwan
    Eur J Clin Invest 35:245-50. 2005
    ..Evidence suggests an increase in oxidative stress in patients with chronic kidney disease, as glomerulosclerosis is the prerequisite for chronic kidney disease; whether the oxidative stress already exists early on is not known...
  69. ncbi Protective effect of beta-glucan against oxidative organ injury in a rat model of sepsis
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Haydarpasa, Istanbul 34668, Turkey
    Int Immunopharmacol 5:1387-96. 2005
    ..the biochemical changes were determined in the brain, diaphragm, kidney, heart, liver and lung tissues using malondialdehyde (MDA) content - an index of lipid peroxidation - glutathione (GSH) levels - a key antioxidant - and ..
  70. ncbi Effects of Panax ginseng extract on exercise-induced oxidative stress
    S H Kim
    Department of Exercise Science, Chungbuk National University, Cheongju, Korea
    J Sports Med Phys Fitness 45:178-82. 2005
    ..This study was designed to study the effects of Panax ginseng extract (PGE) on lipid peroxidation and scavenger enzymes induced by an acute exhaustive exercise in sedentary humans...
  71. ncbi Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet)
    Manal Mohamed Elhassan Taha
    UPM MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400 UPM Serdang, Selangor, Malaysia
    Chem Biol Interact 186:295-305. 2010
    ..05) in ZER-treated than untreated rats with liver cancer. The liver malondialdehyde (MDA) concentrations significantly (P<0...
  72. pmc Effects of antioxidant therapy on leukocyte myeloperoxidase and Cu/Zn-superoxide dismutase and plasma malondialdehyde levels in experimental colitis
    Ergul Belge Kurutas
    Department of Biochemistry, Medical Faculty, Sutcu Imam University, Turkey
    Mediators Inflamm 2005:390-4. 2005
    ..on polymorphonuclear leukocytes myeloperoxidase (MPO) and Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and plasma malondialdehyde (MDA) in acetic acid (AA)-induced ulcerative colitis model...
  73. ncbi Oxidative stress markers and antioxidant levels in normal pregnancy and pre-eclampsia
    J B Sharma
    Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India
    Int J Gynaecol Obstet 94:23-7. 2006
    To compare the levels of 3 oxidative stress markers (glutathione peroxidase [GPX], superoxide dismutase [SOD], and malondialdehyde [MDA]) and 2 antioxidants (vitamin C and lycopene) in healthy and pre-eclamptic pregnant women.
  74. ncbi Melatonin reduces dimethylnitrosamine-induced liver fibrosis in rats
    Veysel Tahan
    Dpeartment of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    J Pineal Res 37:78-84. 2004
    ..b>Malondialdehyde (MDA), an end product of lipid peroxidation, and glutathione (GSH) and superoxide dismutase (SOD) levels were ..
  75. ncbi Role of glutathione peroxidase in protecting mammalian spermatozoa from loss of motility caused by spontaneous lipid peroxidation
    J G Alvarez
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, 19104 6080
    Gamete Res 23:77-90. 1989
    ..These results lead us to postulate a mechanism for spontaneous lipid peroxidation in mammalian sperm which involves reaction of lipid hydroperoxide and O2 as the rate-determining step...
  76. ncbi The effects of gingko biloba extract (EGb 761) on experimental acute pancreatitis
    Nazif Zeybek
    Department of Surgery, Gulhane Military Medical Academy, Ankara, Turkey
    J Surg Res 115:286-93. 2003
    ..In the present study, we aimed to investigate whether Egb761, the standardized extract of gingko biloba, restrains the generation of OFRs and ameliorates the histopathologic findings of acute pancreatitis...
  77. pmc Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia
    Xiaoying Wang
    Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, 149 13th Street, Room 2411A, Charlestown, MA 02129, USA
    Stroke 39:1869-74. 2008
    ..Emerging data suggest that neuroglobin (Ngb) may protect against hypoxic/ischemic neuronal insults. However, the underlying mechanisms in vivo and implications for long-term outcomes are still not well understood...
  78. ncbi Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde
    L T McGrath
    Department of Geriatric Medicine, Queens University of Belfast, Belfast, UK
    QJM 94:485-90. 2001
    ..6, IQR 6.0-25.2 vs. 7.8, 3.3-14.5 micomol/l, respectively; p=0.001) but not malondialdehyde (MDA), and lower levels of ascorbate in AD plasma when compared to age-matched controls (9.9, 6.0-33.7 vs. 24...
  79. ncbi Effect of melatonin against oxidative stress in ultraviolet-B exposed rat lens
    Y Bardak
    Department of Ophthalmology, Suleyman Demirel University Medical School, Isparta, Turkey
    Curr Eye Res 20:225-30. 2000
    ..To investigate the defensive effect of melatonin against oxidative stresses in ultraviolet-B (UVB) radiation induced cataract development...
  80. pmc Effects of blueberry on hepatic fibrosis and transcription factor Nrf2 in rats
    Yu Ping Wang
    Department of Infectious Diseases, Guiyang Medical College, Guiyang 550004, Guizhou Province, China
    World J Gastroenterol 16:2657-63. 2010
    ..To investigate the effects of blueberry on hepatic fibrosis and NF-E2-related factor 2 (Nrf2) transcription factor in rats...
  81. ncbi Urinary trypsin inhibitor suppresses excessive superoxide anion radical generation in blood, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats
    Yasutaka Koga
    Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Japan
    Neurol Res 32:925-32. 2010
  82. ncbi Comparative study of natural antioxidants - curcumin, resveratrol and melatonin - in cadmium-induced oxidative damage in mice
    Vladislav Eybl
    Department of Pharmacology and Toxicology, Charles University in Prague, Faculty of Medicine in Pilsen, Karlovaská 48, 301 66 Pilsen, Czech Republic
    Toxicology 225:150-6. 2006
    ..At 24th h after Cd administration the lipid peroxidation (LP - expressed as malondialdehyde production), reduced glutathione (GSH), catalase (CAT) and glutathione peroxidase (GPx) were estimated in ..
  83. ncbi Neuroprotective effects of (-)-epigallocatechin-3-gallate on aging mice induced by D-galactose
    Miao He
    Department of Pharmacology, Pharmaceutical College of China Medical University, Liaoning Province, PR China
    Biol Pharm Bull 32:55-60. 2009
    ..The activities of total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px) and the contents of malondialdehyde (MDA) in the hippocampus were measured using different biochemical kits to estimate the changes in the ..
  84. ncbi Biomarkers of diabetes-associated oxidative stress and antioxidant status in young diabetic patients with or without subclinical complications
    Pilar Martín-Gallán
    Biochemistry and Molecular Biology Center, Hospital Universitario Vall d Hebron, Barcelona, Spain
    Free Radic Biol Med 34:1563-74. 2003
    ..008). Lipid peroxidation indices measured in plasma included malondialdehyde, lipid hydroperoxides, and lipoperoxides, which were significantly elevated in our diabetic patients ..
  85. ncbi Inhibition of atherosclerosis in apoE-null mice by immunization with apoB-100 peptide sequences
    Gunilla Nordin Fredrikson
    Department of Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 23:879-84. 2003
    ..Immunization of animals with oxidized LDL results in reduction of atherosclerosis, suggesting an atheroprotective effect of this immune response...
  86. ncbi Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans
    S O Olusi
    Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait
    Int J Obes Relat Metab Disord 26:1159-64. 2002
    ..In this study, it is hypothesized that obesity is an independent risk factor for lipid peroxidation and decreased activities of cytoprotective enzymes in humans...
  87. ncbi Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver
    Abir Kasdallah-Grissa
    Laboratoire d Endocrinologie, Departement de Biologie, Faculte des Sciences de Tunis, Tunisia
    Life Sci 80:1033-9. 2007
    ..Conclusively, we can suggest that resveratrol could have a beneficial effect in inhibiting the oxidative damage induced by chronic ethanol administration, which was proved by the experiments that we conducted on rats...
  88. ncbi Percutaneous coronary intervention results in acute increases in oxidized phospholipids and lipoprotein(a): short-term and long-term immunologic responses to oxidized low-density lipoprotein
    Sotirios Tsimikas
    Vascular Medicine Program, Department of Medicine, University of California San Diego, 9500 Gilman Drive, BSB 1080, La Jolla, CA 92093 0682, USA
    Circulation 109:3164-70. 2004
    ..This study was performed to assess whether oxidized low-density lipoprotein (OxLDL) levels are elevated after percutaneous coronary intervention (PCI)...
  89. ncbi Measurement of lipid peroxidation
    K Moore
    Department of Medicine, Royal Free Hospital School of Medicine, London, UK
    Free Radic Res 28:659-71. 1998
  90. ncbi Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors
    Suchet D Khanzode
    Department of Pharmacology, Government Medical College, Nagpur, India
    Redox Rep 8:365-70. 2003
    ..Treatment with fluoxetine and citalopram reversed these biochemical parameters. This study can be used as a predictor of drug response by fluoxetine and citalopram in major depression...
  91. ncbi Prophylactic effect of N-acetylcysteine against sodium fluoride-induced blood oxidative stress in mice
    Levent Altintas
    Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ankara, Ankara, Turkey
    Food Chem Toxicol 48:2838-41. 2010
    ..Plasma malondialdehyde (MDA) levels and erythrocyte superoksid dismutase (SOD) and catalase (CAT) activities were determined at the ..
  92. ncbi Serum superoxide dismutase and malondialdehyde levels in a group of Chinese patients with age-related macular degeneration
    Lihong Jia
    School of Public Health, China Medical University, Shenyang 110001, China
    Aging Clin Exp Res 23:264-7. 2011
    The aim of this study was to investigate superoxide dismutase (SOD) activity together with malondialdehyde (MDA) levels in a group of Chinese patients with age-related macular degeneration (AMD).
  93. ncbi Effect of selected antioxidants in beta-cyfluthrin-induced oxidative stress in human erythrocytes in vitro
    Izabela Sadowska-Woda
    Department of Biochemistry and Cell Biology, University of Rzeszow, ul Pigonia 6, 35 959 Rzeszow, Poland
    Toxicol In Vitro 24:879-84. 2010
    ..b>Malondialdehyde (MDA) concentrations, CAT and SOD activities, as well as haemolysis percentage (H) were measured in all ..
  94. pmc The combined transduction of copper, zinc-superoxide dismutase and catalase mediated by cell-penetrating peptide, PEP-1, to protect myocardium from ischemia-reperfusion injury
    Guang Qing Huang
    Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China
    J Transl Med 9:73. 2011
    ..The aim of this study is to explore whether combined use of PEP-1-SOD1 and PEP-1-CAT enhances their protective effects...
  95. ncbi Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat
    A Armagan
    Department of Urology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
    Hum Exp Toxicol 27:547-52. 2008
    ..In the tissue, the level of lipid peroxidation as malondialdehyde and activities of superoxide dismutase were higher in the methotrexate group than in the control group...
  96. ncbi Aflatoxin B1 and fumonisin B1 affect the oxidative status of bovine peripheral blood mononuclear cells
    Umberto Bernabucci
    Department of Animal Science, University of Tuscia, via S C de Lellis, 01100 Viterbo, Italy
    Toxicol In Vitro 25:684-91. 2011
    ..Reactive oxygen metabolites (ROM), intracellular thiols (SH), malondialdehyde (MDA) and gene expression of cytoplasmic superoxide dismutase (SOD) and glutathione peroxidase (GSHPX-1) were ..
  97. ncbi Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation
    Lan He
    Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China
    Eur J Pharmacol 678:32-8. 2012
    ..cardiac function, activities of creatine kinase (CK) and ALDH2, contents of 4-hydroxy-2-nonenal (4-HNE) and malondialdehyde (MDA) were measured...
  98. ncbi Membrane peroxidation by lipopolysaccharide and iron-ascorbate adversely affects Caco-2 cell function: beneficial role of butyric acid
    Frederic Courtois
    Division of Gastroenterology, Hepatology, and Nutrition, Centre de Recherche, Sainte Justine Hospital and the Department of Nutrition, Universite de Montreal, Montreal, Quebec, Canada
    Am J Clin Nutr 77:744-50. 2003
    ..Membrane lipid peroxidation may play a role in immune-mediated bowel diseases...
  99. ncbi Curcumin pretreatment protects against acute acrylonitrile-induced oxidative damage in rats
    Xing Guangwei
    Department of Preventive Medicine, School of Medical Science and Laboratory Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China
    Toxicology 267:140-6. 2010 AN significantly increased the generation of lipid peroxidation products, reflected by high levels of malondialdehyde (MDA) both in the brain and liver...
  100. ncbi Protective effects of capsaicin against cisplatin-induced nephrotoxicity in rats
    Yuka Shimeda
    Department of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences, Osaka, Japan
    Biol Pharm Bull 28:1635-8. 2005
    ..the kidney glutathione (GSH) content and superoxide dismustase (SOD) activity and a significant increase in malondialdehyde (MDA) production in comparison to the values at 0 h (p < 0.05)...
  101. ncbi Hydroxysafflor yellow A protects rat brains against ischemia-reperfusion injury by antioxidant action
    Xinbing Wei
    Department of Pharmacology, School of Medicine, Shandong University, Wenhua West Road 44, Jinan, Shandong 250012, PR China
    Neurosci Lett 386:58-62. 2005
    ..Spectrophotometric assay was used to determine the content of malondialdehyde (MDA), and the activity of total antioxidative capability (T-AOC) and superoxide dismutase (SOD)...

Research Grants63

  1. Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Mark M Huycke; Fiscal Year: 2012
    ..The ability of E. faecalis to induce cyclooxygenase-2, prostanoids, TNF1, malondialdehyde and 4- hydroxynonenal in the colonic mucosa of interleukin (IL)-10 knockout mice will be determined...
  2. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..1) Reduced tissue injury, manifested by the level of tissue necrosis (histology score), lipid peroxidation (malondialdehyde, F21-isoprostane), PMN infiltration (myeloperoxidase), apoptosis (TUNEL staining), 3-nitrotyrosine (a measure ..
  3. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
    ..necropsy will be analyzed for pulmonary vascular structure and growth, alveolarization, lipid peroxidation (malondialdehyde), glutathione (GSH/GSSG ratio), peroxynitrite formation (3-nitrotyrosine), poly(ADP-ribose) formation, ..
  4. A Novel Thioredoxin Mimetic Prodrug for Prevention of Bronchopulmonary Dysplasia
    Prakash Jagtap; Fiscal Year: 2013
    ..necropsy will be analyzed for pulmonary vascular structure and growth, alveolarization, lipid peroxidation (malondialdehyde), reduced and oxidized glutathione (GSH, GSSG), peroxynitrite formation (3-nitrotyrosine), poly(ADP-ribose) ..
  5. Pain and Hypoxia in Premature Neonates
    DANILYN MAG AKAT ANGELES; Fiscal Year: 2012
    ..increase biochemical markers of cell injury Cell injury will be quantified by measuring plasma levels of malondialdehyde (MDA), a marker for lipid peroxidation...
  6. Lipid peroxidation product induced DNA damage in the p53 gene and liver cancer
    ERIC MOON SHONG M TANG; Fiscal Year: 2010
    ..LPO generates a variety of aldehydes, such as acrolein (Acr), crotonaldehyde, malondialdehyde (MDA), and trans-4-hydroxy- 2-nonenal (4-HNE), that are able to interact with DNA;these adducts induce mainly ..
  7. Alcohol &Antiretrovirals in HIV Infection, Oxidative Stress and Liver Disease
    Marianna K Baum; Fiscal Year: 2012
    ..Blood will be drawn for oxidative stress (malondialdehyde to indicate lipid peroxidation, protein carbonyls for protein oxidation, 8-hydroxyguanosine for DNA oxidation)..
  8. Phase 2 Study of High Dose DHA for the Treatment of X-Linked Retinitis Pigmentosa
    Dennis R Hoffman; Fiscal Year: 2013
    ..Based on Phase 1 clinical trial results, a high dose of dietary DHA shows promise in retarding progression of this blinding eye disease. ..
  9. Aldehydes in Alcohol-Induced Organ Injury
    Zhanxiang Zhou; Fiscal Year: 2013
    ..generates acetaldehyde, lipid peroxidation produces lipid aldehydes such as 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA)...
    Vickram Ramkumar; Fiscal Year: 1999
    ..A3AR-mediated protection will be assessed by determining the levels of reduced and oxidized glutathione, malondialdehyde and by electron microscopic studies of cellular organelles. 3...
  11. Lipid electrophile adduction of Pin1 and effects on substrate binding &activity
    Christopher D Aluise; Fiscal Year: 2013
    ..that have been extensively studied are 4-hydroxynonenal (4-HNE), 4- oxononenal (4-ONE), acrolein, and malondialdehyde. Adduction by lipid electrophiles distorts protein tertiary structure and typically has adverse effects on ..
    Fung Lung Chung; Fiscal Year: 2010
    ..the major sites of modification in DNA by enals: acrolein (Acr-dG), t-4-hydroxy-2-nonenal (HNE-dG), and malondialdehyde (MdG)...
  13. Characterization of Aging in Sea Urchin Species with Different Life Spans
    Andrea Bodnar; Fiscal Year: 2012
    ..overall levels of cellular damage such as lipofuscin, 8-hydroxydeoxyguanosine, protein carbonyls and malondialdehyde in tissues from animals of different ages spanning the life span of each species...
  14. Effect of cysteine on glutathione production in critically ill neonates
    STEPHEN SHEW; Fiscal Year: 2010
    ..tracer technique with [13C]-glycine, (2) to measure plasma interleukin-6, tumor necrosis factor-a, and malondialdehyde concentrations as determinants of inflammatory response severity and degree of oxidative tissue injury, and (..
  15. Biomarkers of Oxidative Stress in Parkinson's Disease
    M Flint Beal; Fiscal Year: 2010
    ..We will measure plasma levels of 8-OHdG, malondialdehyde, ascorbic acid, uric acid, oxidized and reduced CoQ10, and oxidized and reduced glutathione...
  16. mtDNA mutation/heteroplasmy: a sensitive functional biomarker of oxidative stress
    Bruce N Ames; Fiscal Year: 2010
    ..Van Houten);metabolomics by LCMS (J. Suh) for changes to redox status;and malondialdehyde (MDA) by GCMS for oxidative stress developed in our lab and widely used...
    Lawrence J Marnett; Fiscal Year: 2013
    ..We are particularly interested in the lipid oxidation product, malondialdehyde (MDA), and the DNA oxidation products, base propenals...
  18. Oxidation-specific nanoparticles for imaging atherosclerosis
    Sotirios Tsimikas; Fiscal Year: 2013
    ..Several of these oxidation-specific epitopes, such as oxidized phospholipids and malondialdehyde-lysine epitopes, have been well characterized in our laboratory and specific murine and fully human ..
  19. Airway Injury Caused by MAA Adducts
    Todd A Wyatt; Fiscal Year: 2012
    ..Large concentrations of malondialdehyde and acetaldehyde are found in the lungs of smoking alcoholics...
    Henry Kaplan; Fiscal Year: 1980
    ..I will explore the production of peroxides through measurement of formate oxidation and generation of malondialdehyde and determine the effects of ADR on glutathione peroxidase, glutathione (GSH) and oxidized glutathione (GSSG) ..
    Manuela Gago Dominguez; Fiscal Year: 2009
    ..alcohol intake) factors for colorectal cancer are associated with plasma lipid peroxidation products [malondialdehyde, (MDA) and lipid peroxides] among controls. 2.1...
  22. Use of Probiotic Conditioned Media to Protect Against Necrotizing Enterocolitis
    ERIKA CLAUD; Fiscal Year: 2009
    ..also evaluate differences in oxidant-mediated injury by measuring oxidant markers such as xanthine oxidase, malondialdehyde, and nitric oxide production...
  23. DNA Adduct-Induced Mutagenesis
    Michael P Stone; Fiscal Year: 2013
    ..g., in the case of malondialdehyde (MDA), 5,6-dihydroxy-dihydro-2'-thymlne or Tg, or Irreversible, in the case of aflatoxin B{1} (AFB{1})...
    Sahebarao Mahadik; Fiscal Year: 2002
    ..Specific measures will include membrane lipid peroxidation products (malondialdehyde, MDA), phospholipase A2 (PLA2), conjugated dienes and fatty acid contents, levels of carbonylated proteins, ..
  25. Preventing NIHL by enhancing glutathione pathways
    Richard Kopke; Fiscal Year: 2002
    ..of noise exposure and that these changes will correlate with the level of lipid peroxidation as measured by malondialdehyde (MDA) levels...
  26. Novel xanthine oxidase inhibitor for arthritis
    Zsuzsanna Zsengeller; Fiscal Year: 2004
    ..that AN-260 will dose-dependently ameliorate gross and histologic injury, preserve joint function, diminish malondialdehyde formation (a marker of lipid peroxidation), and decrease myeloperoxidase activity (a marker of neutrophil ..
    Kathleen Schwarz; Fiscal Year: 1993
    ..Correlation of breath ethane with another measure of lipid peroxidation, (plasma malondialdehyde) will be done...
    Linda La Grange; Fiscal Year: 2000
    ..24-hr exposure to EtOH prevented the decrease in glutathione (GSH), restored cell replication, and moderated malondialdehyde (MDA) production...
    Robert Russell; Fiscal Year: 2005 both plasma and lung tissue; and B) the degree of oxidative stress status by measuring isoprostane and malondialdehyde levels in both plasma and lung tissue of ferret; and 3) To determine if vitamins C and E will inhibit the ..
    Robert Terkeltaub; Fiscal Year: 1993 macrophages, and the ability to complete in solid-phase RIAs for three epitopes present in oxidized LDL: (malondialdehyde(MDA)-lysine, 4-hydroxynonenal(HNE)-lysine, and a unique apo B epitope)...
    Elizabeth McNiel; Fiscal Year: 2005
    ..of the antioxidant glutathione in conjunction with indicators of oxidant exposure, oxidized glutathione and malondialdehyde, a product of lipid peroxidation...
    Curtis Klaassen; Fiscal Year: 2000
    ..interleukin-1 and interleukin-6 vs blood urea nitrogen), (c) histology (localization of 4-hydroxynonenal- and malondialdehyde-adducts vs histopathology), (d) tissue analysis (antioxidant components vs tissue Cd content), and (e) ..
    JAMES JESSUP; Fiscal Year: 2000
    ..Two markers of free radical-induced oxidative stress in vivo, plasma concentrations of malondialdehyde (MDA) and lipid hydroperoxide (LHP)...
    James Loyd; Fiscal Year: 1992
    ..Lipid peroxidation products, including conjugated dienes and malondialdehyde, increase during reperfusion and suggest that free radical oxidant injury is contributory to the lung ..
    Peter Thomas; Fiscal Year: 2005
    ..on serotonergic functions, and its efficacy in reversing the effects of the PCB on lipid peroxidation, malondialdehyde-protein adduct formation, TPH activity, and neuroendocrine function, will be investigated...
  36. Regular Exercise Among Women at Risk for Preeclampsia
    SeonAe Yeo; Fiscal Year: 2005 level, blood pressure, blood sample for serum iron, transferrin, low density lipoprotein, malondialdehyde, superoxide dismutase...
    Andrew Salzman; Fiscal Year: 1999
    ..neutrophil infiltration), cytokine mRNA expression for TNF-alpha, IL-Ibeta, IL-6, iNOS, and IL-8 (by RT-PCR), malondialdehyde (marker of lipoperoxidation), and immunohistochemistry (to identify iNOS expression and nitrotyrosine ..
    John Hauth; Fiscal Year: 1991
    ..fetoplacental unit will be evaluated by measurements of salicylate, thrombin-induced platelet production of malondialdehyde, TXB, 6-keto-PGF, progesterone and estriol in maternal blood each 4 weeks from 24 weeks' gestation until ..
    Hidekazu Tsukamoto; Fiscal Year: 2003
    ..vitro and in vivo evidence are also available to incriminate aldehydic products of lipid peroxidation such as malondialdehyde (MDA) and 4-hydroxynonenal (4HNE), as additional inducers of Ito cell collagen gene expression...
  40. Liver Fibrosis, Inflammation & Oxidative Stress Markers
    Charles Lieber; Fiscal Year: 2006
    ..Accordingly, the correlation of markers of oxidative stress (4-hydroxynonenal, F2-isoprostanes and malondialdehyde) with the degree of CYP2E1 induction in the liver will be evaluated...
    EVA GOTTSCHALL; Fiscal Year: 2005
    ..using markers of oxidative cellular damage, including 8-hydroxydeoxyguanosine (a marker of DNA damage), malondialdehyde (a marker of lipid peroxidation), and 8-iso-prostaglandine F2, (a marker of lipid peroxidation), before and ..
    YEI MEI PENG; Fiscal Year: 1999
    ..vitamins C, E and A, two potential oxidative damage biomarkers, 8-hydroxydeoxyguanosine (primary marker) and malondialdehyde (secondary marker), and cotinine will be measured in blood and/or urine...
    DENNIS PETERSEN; Fiscal Year: 2004
    ..establish the mechanistic role(s) of aldehydic products of lipid peroxidation (4-hydroxynonenal [4-HNE] and malondialdehyde [MDA]) in chemical-induced liver fibrosis...
  44. Alzheimer's Disease in Down Syndrome: Antioxidant Trial
    Ira Lott; Fiscal Year: 2005
    ..the FULD-Object/Memory Test-modified); 2) to determine whether plasma biomarkers of lipid oxidative damage (malondialdehyde, isoprostanes), protein oxidative damage (carbonyl group formation), levels of beta-amyloid, and vitamin E ..
    Arthur Cohen; Fiscal Year: 1980
    ..correlate the activity of GPO in the livers of selenium-deficient and selenium-supplemented rats with hepatic malondialdehyde concentrations at various intervals after the addition of FAA to their diets...
    CYNTHIA SEVILLA; Fiscal Year: 1990
    ..The simplest examples of such compounds are malondialdehyde, acrolein and methyl glyoxal...
    WALTER EISENBERG; Fiscal Year: 1990
    ..The overall goal of the research is to determine if there is a link between atmospherically generated O2- and some of the adverse health effects attributed to air pollution...
    Thomas Harris; Fiscal Year: 1999
    ..e., IPP), (2) three-atom tethers: malondialdehyde, acrolein, and crotonaldehyde and (3) two-atom tethers 1-chlorooxirane, chloroacetaldehyde, and glyoxal...
    KAILASH BHUYAN; Fiscal Year: 1999
    ..sequentially, by detecting membrane lipid-derived oxidant species such as conjugated dienes, LOOH, malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), by UV spectrophotometry and HPLC in normal lenses of human donor eyes as ..
    Dean Tuma; Fiscal Year: 2001
    Recent studies have shown that acetaldehyde and the lipid peroxidation-derived aldehyde, malondialdehyde, can react together with proteins in a synergistic manner to form distinct hybrid adducts which have been designated as MAA adducts...
    Thelma Patrick; Fiscal Year: 1999
    ..relevance of these hypotheses to pregnant black women we measured lipids and a marker of oxidative stress, malondialdehyde. This was stimulated by the known association of dyslipidemia and oxidative stress and previous documentation ..
  52. Exercise and Kidney Dopamine Receptor Function in Aging
    Mohammad Asghar; Fiscal Year: 2009
    ..In preliminary studies, we found that 6-week treadmill exercise in old rats decreased levels of malondialdehyde (a marker of oxidative stress) and increased expression and activity of superoxide dismutase (an anti-oxidant ..
    Andrew Salzman; Fiscal Year: 2000
    ..of mucosal injury, myeloperoxidase activity (a marker of neutrophil infiltration), F2-isoprostane and malondialdehyde concentration (markers of lipoperoxidation), pro-inflammatory cytokine and chemokine expression, and iNOS and ..
  54. Reactive Aldehyde DNA Damage in Mitochondrial Mutagenesis and Disease Pathophysio
    SUSAN CLINE; Fiscal Year: 2009
    ..ROS interact with lipids and nucleic acids to release a host of reactive aldehydes, including malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and nucleic acid base propenals [1,12, 25]...
    LAWRENCE MARNETT; Fiscal Year: 2004
    ..Our laboratory has demonstrated that DNA adducts derived from the lipid oxidation product, malondialdehyde (MDA), are present in genomic DNA of healthy human beings...
    WILLIAM CLERICI; Fiscal Year: 2000
    ..ROS scavengers to protect against cochlear disruption and by correlating these changes with assayed levels of malondialdehyde (MDA), conjugated dienes and carbonyl in the cochlea, 2) determine, in vivo and in vitro, whether TMT ..
    DENNIS PETERSEN; Fiscal Year: 2005
    ..establish the mechanistic role(s) of aldehydic products of lipid peroxidation (4-hydroxynonenal [4-HNE] and malondialdehyde [MDA] in alcoholic liver disease (ALD)...
  58. In Vivo Microdialysis Studies of Oxidative Stress
    Craig Lunte; Fiscal Year: 2006
    ..All of these analytes will be detected using electrochemical methods. Malondialdehyde will be derivatized to a fluorescent analyte and determined by laser induced fluorescence...
    David Simon; Fiscal Year: 2001
    ..DNA, proteins, and lipids by measuring 8-hydroxy-2-deoxyguanosine, protein carbonyls and 3-nitrotyrosine, and malondialdehyde, respectively, and to correlate these findings with clinical features of disease...
  60. Fats, Immune Response and Atherosclerosis
    Ngoc Anh Le; Fiscal Year: 2002
    ..Two modes of stimulation of the immune response will be examined: immunization with malondialdehyde-modified homologous LDL and supplementation of the diet with polyunsaturated fatty acids...
    RAJINDAR SOHAL; Fiscal Year: 2007
    ..Proteins exhibiting oxidative modifications such as carbonylation, 4-hydroxy 2-nonenal adducts, malondialdehyde adducts and 3-nitro modification of tyrosine residues will be detected immunochemically...
    Mark Kearley; Fiscal Year: 2000
    ..and malondialdehyde as the precursors to hepatotoxicity...
    Sidney Nelson; Fiscal Year: 1992
    ..with nitrogen-phosphorus detection) for hydrazine derivatives of two major aldehydes of lipid peroxidation, malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), 2) to synthesize, characterize, and develop assays (HPLC with ..