formaldehyde

Summary

Summary: A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)

Top Publications

  1. ncbi Whole-genome gene expression profiling of formalin-fixed, paraffin-embedded tissue samples
    Craig April
    Illumina, Inc, San Diego, California, United States of America
    PLoS ONE 4:e8162. 2009
  2. ncbi FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin
    Paul G Giresi
    Department of Biology and the Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    Genome Res 17:877-85. 2007
  3. ncbi RNA expression analysis from formalin fixed paraffin embedded tissues
    Susan M Farragher
    Almac Diagnostics, Craigavon, 19 Seagoe Industrial Estate, Armagh BT635QD, UK
    Histochem Cell Biol 130:435-45. 2008
  4. ncbi Generation of high-quality protein extracts from formalin-fixed, paraffin-embedded tissues
    Maria Filippa Addis
    Porto Conte Ricerche Srl, Tramariglio, Alghero, Sassari, Italy
    Proteomics 9:3815-23. 2009
  5. ncbi Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    Yujiang Shi
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Cell 119:941-53. 2004
  6. ncbi TRPA1 mediates formalin-induced pain
    Colleen R McNamara
    Hydra Biosciences, Inc, 790 Memorial Drive, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:13525-30. 2007
  7. ncbi Isolation of active regulatory elements from eukaryotic chromatin using FAIRE (Formaldehyde Assisted Isolation of Regulatory Elements)
    Paul G Giresi
    Department of Biology and Carolina Center for the Genome Sciences, University of North Carolina at Chapel Hill, CB 3280, 408 Fordham Hall, Chapel Hill, NC 27599 3280, USA
    Methods 48:233-9. 2009
  8. ncbi Comparison of miRNA expression patterns using total RNA extracted from matched samples of formalin-fixed paraffin-embedded (FFPE) cells and snap frozen cells
    Jinghuan Li
    Department of Histopathology, University of Dublin, Trinity College, Dublin, Ireland
    BMC Biotechnol 7:36. 2007
  9. ncbi Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against disease
    Kien Chai Ong
    Department of Pathology, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Virol 84:661-5. 2010
  10. ncbi Tissue handling and specimen preparation in surgical pathology: issues concerning the recovery of nucleic acids from formalin-fixed, paraffin-embedded tissue
    Stephen M Hewitt
    Tissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4605, USA
    Arch Pathol Lab Med 132:1929-35. 2008

Research Grants

  1. Nanopore Biosensor for Kinetics of Reparative Antibodies on Plasma Membranes
    Sang Hyun Oh; Fiscal Year: 2010
  2. Innate immune evasion and/or antagonism by eastern equine encephalitis virus
    KATHERINE RYMAN; Fiscal Year: 2007
  3. True Direct Single Molecule RNA Sequencing
    PATRICE MARIE MILOS; Fiscal Year: 2010
  4. Developing an inactivated whole cell H. pylori vaccine
    GARY NABORS; Fiscal Year: 2006
  5. Immunoprotective monoclonals to B. anthracis spores
    ALISON O BRIEN; Fiscal Year: 2003
  6. Molecular signatures of melanoma histology and progression: A Population Based A
    Abrar A Qureshi; Fiscal Year: 2010
  7. Molecular signatures of melanoma histology and progression: A Population Based A
    Abrar Qureshi; Fiscal Year: 2009
  8. Early Diagnosis of Oral Carcinoma Using Mutant PP32R1
    GERALD KOCHEVAR; Fiscal Year: 2006
  9. RSV Upper Airway Infection and Otitis Media
    JOAN E contact DURBIN; Fiscal Year: 2010
  10. RSV Upper Airway Infection and Otitis Media
    Joan Durbin; Fiscal Year: 2009

Detail Information

Publications254 found, 100 shown here

  1. ncbi Whole-genome gene expression profiling of formalin-fixed, paraffin-embedded tissue samples
    Craig April
    Illumina, Inc, San Diego, California, United States of America
    PLoS ONE 4:e8162. 2009
    ..We have developed a gene expression assay (Whole-Genome DASL), capable of generating whole-genome gene expression profiles from degraded samples such as formalin-fixed, paraffin-embedded (FFPE) specimens...
  2. ncbi FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin
    Paul G Giresi
    Department of Biology and the Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    Genome Res 17:877-85. 2007
    ..demonstrate a simple procedure for the isolation of nucleosome-depleted DNA from human chromatin, termed FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements)...
  3. ncbi RNA expression analysis from formalin fixed paraffin embedded tissues
    Susan M Farragher
    Almac Diagnostics, Craigavon, 19 Seagoe Industrial Estate, Armagh BT635QD, UK
    Histochem Cell Biol 130:435-45. 2008
    ..This paper reviews the progress in this field and discusses the unique opportunities that exist for the application of these techniques in the development of personalized medicine...
  4. ncbi Generation of high-quality protein extracts from formalin-fixed, paraffin-embedded tissues
    Maria Filippa Addis
    Porto Conte Ricerche Srl, Tramariglio, Alghero, Sassari, Italy
    Proteomics 9:3815-23. 2009
    ..An evaluation of the extent of modifications introduced on proteins by formalin fixation and crosslink reversal, and their impact on quality of MS results, is also reported...
  5. ncbi Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    Yujiang Shi
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Cell 119:941-53. 2004
    ..Lysine demethylation occurs via an oxidation reaction that generates formaldehyde. Importantly, RNAi inhibition of LSD1 causes an increase in H3 lysine 4 methylation and concomitant ..
  6. ncbi TRPA1 mediates formalin-induced pain
    Colleen R McNamara
    Hydra Biosciences, Inc, 790 Memorial Drive, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:13525-30. 2007
    ....
  7. ncbi Isolation of active regulatory elements from eukaryotic chromatin using FAIRE (Formaldehyde Assisted Isolation of Regulatory Elements)
    Paul G Giresi
    Department of Biology and Carolina Center for the Genome Sciences, University of North Carolina at Chapel Hill, CB 3280, 408 Fordham Hall, Chapel Hill, NC 27599 3280, USA
    Methods 48:233-9. 2009
    ..a simple procedure for the genome-wide isolation of nucleosome-depleted DNA from human chromatin, termed FAIRE (Formaldehyde Assisted Isolation of Regulatory Elements)...
  8. ncbi Comparison of miRNA expression patterns using total RNA extracted from matched samples of formalin-fixed paraffin-embedded (FFPE) cells and snap frozen cells
    Jinghuan Li
    Department of Histopathology, University of Dublin, Trinity College, Dublin, Ireland
    BMC Biotechnol 7:36. 2007
    ..This study analyzed 160 miRNAs in paired snap frozen and FFPE cells to investigate if miRNAs may be successfully detected in archival specimens...
  9. ncbi Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against disease
    Kien Chai Ong
    Department of Pathology, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Virol 84:661-5. 2010
    ..b>Formaldehyde-inactivated whole-virus vaccines derived from EV71 clinical isolates and a mouse-adapted virus (MAV) were ..
  10. ncbi Tissue handling and specimen preparation in surgical pathology: issues concerning the recovery of nucleic acids from formalin-fixed, paraffin-embedded tissue
    Stephen M Hewitt
    Tissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4605, USA
    Arch Pathol Lab Med 132:1929-35. 2008
    ..High-quality nucleic acids can be obtained from formalin-fixed, paraffin-embedded tissue, but greater attention to all steps in the process of tissue handling and preparation is required...
  11. ncbi Quantitative protein analysis from formalin-fixed tissues: implications for translational clinical research and nanoscale molecular diagnosis
    K F Becker
    Technische Universitat, Institut fur Pathologie, Munchen, Germany
    J Pathol 211:370-8. 2007
    ..This technique may also be used to identify, characterize, and validate known and new protein markers in a variety of human diseases...
  12. ncbi Genome-wide massively parallel sequencing of formaldehyde fixed-paraffin embedded (FFPE) tumor tissues for copy-number- and mutation-analysis
    Michal R Schweiger
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 4:e5548. 2009
    ..However, FFPE preparation is incompatible with many down-stream molecular biology techniques such as PCR based amplification methods and gene expression studies...
  13. ncbi Formaldehyde-based whole-mount in situ hybridization method for planarians
    Bret J Pearson
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Dev Dyn 238:443-50. 2009
    ..Here, we describe a formaldehyde-based WISH method for the freshwater planarian Schmidtea mediterranea developed by systematically comparing and ..
  14. ncbi Optimization of RNA extraction from FFPE tissues for expression profiling in the DASL assay
    Mark Abramovitz
    VM Institute of Research, Montreal, Quebec, Canada
    Biotechniques 44:417-23. 2008
    ....
  15. ncbi Direct cancer tissue proteomics: a method to identify candidate cancer biomarkers from formalin-fixed paraffin-embedded archival tissues
    S I Hwang
    Department of Cell Biology, Center for Vascular Biology, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    Oncogene 26:65-76. 2007
    ..We propose that this general strategy provides a roadmap for successful identification of critical molecular targets of multiple cancer types...
  16. ncbi Evaluation and validation of total RNA extraction methods for microRNA expression analyses in formalin-fixed, paraffin-embedded tissues
    Martina Doleshal
    Asuragen, Inc, Austin, TX 78744, USA
    J Mol Diagn 10:203-11. 2008
    ....
  17. ncbi The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain
    Gabriele Ugolini
    Lay Line Genomics, Via di Castel Romano 100, 00128 Rome, Italy
    Proc Natl Acad Sci U S A 104:2985-90. 2007
    ..This study represents a direct demonstration that neutralizing antibodies directed against the TrkA receptor may display potent analgesic effects in inflammatory and chronic pain...
  18. ncbi miRNA in situ hybridization in formaldehyde and EDC-fixed tissues
    John T G Pena
    Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 186, New York, New York 10065, USA
    Nat Methods 6:139-41. 2009
    ..We showed that in situ hybridization (ISH) using conventional formaldehyde fixation results in substantial microRNA loss from mouse tissue sections, which can be prevented by fixation ..
  19. ncbi Clinical proteomic applications of formalin-fixed paraffin-embedded tissues
    Josip Blonder
    Laboratory of Proteomics and Analytical Technologies, SAIC Frederick, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, MD 21702, USA
    Clin Lab Med 29:101-13. 2009
    ..The almost inexhaustible supply of these tissues will enable proteomic laboratories access to clinically important specimens that will undoubtedly lead to a number of important discoveries in the near future...
  20. ncbi The generation of formaldehyde in cigarettes--Overview and recent experiments
    Richard R Baker
    Group Research and Development, British American Tobacco, Regent s Park Road, Southampton SO15 8TL, UK
    Food Chem Toxicol 44:1799-822. 2006
    ..One exception to this generalisation is formaldehyde, which is generated from saccharides used as tobacco ingredients...
  21. ncbi Enhanced formaldehyde detoxification by overexpression of glutathione-dependent formaldehyde dehydrogenase from Arabidopsis
    Hakima Achkor
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Plant Physiol 132:2248-55. 2003
    The ADH2 gene codes for the Arabidopsis glutathione-dependent formaldehyde dehydrogenase (FALDH), an enzyme involved in formaldehyde metabolism in eukaryotes...
  22. ncbi Genome-wide comparison of paired fresh frozen and formalin-fixed paraffin-embedded gliomas by custom BAC and oligonucleotide array comparative genomic hybridization: facilitating analysis of archival gliomas
    Gayatry Mohapatra
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Acta Neuropathol 121:529-43. 2011
    ..In combination, these advances should facilitate genome-wide analysis of rare, small and/or histologically heterogeneous gliomas from FFPE tissues...
  23. ncbi Analyses and interpretation of whole-genome gene expression from formalin-fixed paraffin-embedded tissue: an illustration with breast cancer tissues
    Muhammad G Kibriya
    Department of Health Studies, The University of Chicago, 5841 S, Maryland Avenue, MC 2007, Chicago, IL 60637, USA
    BMC Genomics 11:622. 2010
    ..We used a whole genome DASL assay (addressing 18,391 genes) on a total of 72 samples from paired breast tumor and surrounding healthy tissues from both FF and FFPE samples...
  24. ncbi Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound
    Melvin E Andersen
    Program in Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 118:716-31. 2010
    b>Formaldehyde (FA), an endogenous cellular aldehyde, is a rat nasal carcinogen...
  25. ncbi Quantitation of p95HER2 in paraffin sections by using a p95-specific antibody and correlation with outcome in a cohort of trastuzumab-treated breast cancer patients
    Jeff Sperinde
    diaDexus, South San Francisco, CA, USA
    Clin Cancer Res 16:4226-35. 2010
    ..We sought to show that quantitative p95HER2 levels would correlate with outcome in trastuzumab-treated HER2-positive metastatic breast cancer...
  26. ncbi Proteomic analysis of formalin-fixed prostate cancer tissue
    Brian L Hood
    Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    Mol Cell Proteomics 4:1741-53. 2005
    ....
  27. ncbi Whole genome SNP arrays using DNA derived from formalin-fixed, paraffin-embedded ovarian tumor tissue
    Ella R Thompson
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Hum Mutat 26:384-9. 2005
    ..This advance will open up vast archival tissue resources to high-resolution genetic analysis and unlock a wealth of biological information...
  28. ncbi Quality assessment of DNA derived from up to 30 years old formalin fixed paraffin embedded (FFPE) tissue for PCR-based methylation analysis using SMART-MSP and MS-HRM
    Lasse S Kristensen
    Institute of Human Genetics, University of Aarhus, The Bartholin Building, Aarhus C, Denmark
    BMC Cancer 9:453. 2009
    ..Sensitive Melting Analysis after Real Time - Methylation Specific PCR (SMART-MSP) and Methylation Sensitive - High Resolution Melting (MS-HRM) are two methods for single locus DNA methylation detection based on HRM...
  29. ncbi Treatment of maternal blood samples with formaldehyde does not alter the proportion of circulatory fetal nucleic acids (DNA and mRNA) in maternal plasma
    Satheesh Kumar Reddy Chinnapapagari
    Department of Research, University Women's Hospital, Basel, Switzerland
    Clin Chem 51:652-5. 2005
  30. ncbi Lack of dramatic enrichment of fetal DNA in maternal plasma by formaldehyde treatment
    Grace T Y Chung
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Clin Chem 51:655-8. 2005
  31. ncbi Epidemiological studies of formaldehyde exposure and risk of leukemia and nasopharyngeal cancer: a meta-analysis
    Annette M Bachand
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA
    Crit Rev Toxicol 40:85-100. 2010
    The authors conducted meta-analyses of the epidemiological literature on formaldehyde exposure and risk of leukemia and risk of nasopharyngeal cancer...
  32. ncbi Formaldehyde exposure and asthma in children: a systematic review
    Gerald McGwin
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Environ Health Perspect 118:313-7. 2010
    Despite multiple published studies regarding the association between formaldehyde exposure and childhood asthma, a consistent association has not been identified...
  33. ncbi Efficient method for the proteomic analysis of fixed and embedded tissues
    Darryl Erik Palmer-Toy
    Harvard Partners Center for Genetics and Genomics, Cambridge, Massachusetts, USA
    J Proteome Res 4:2404-11. 2005
    ..Moreover, we demonstrate that a high level of sequence coverage can be observed for proteins of interest...
  34. ncbi In vivo stabilization of preinitiation complexes by formaldehyde cross-linking
    LEOS VALASEK
    Institute of Microbiology, AS CR, Prague, Czech Republic
    Methods Enzymol 429:163-83. 2007
    ..Therefore, we developed an alternative method for PIC stabilization using formaldehyde (HCHO) to cross-link factors associated with 40S ribosomal subunits in vivo before the disruption of the yeast ..
  35. ncbi Mass spectrometric analysis of formalin-fixed paraffin-embedded tissue: unlocking the proteome within
    Brian L Hood
    Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    Proteomics 6:4106-14. 2006
    ..Although these developments are quite new, the ability to conduct MS-based proteomic analyses of FFPE tissues opens heretofore intractable clinical samples for discovery-based biomarker research...
  36. ncbi Evaluation of archival time on shotgun proteomics of formalin-fixed and paraffin-embedded tissues
    Brian M Balgley
    Calibrant Biosystems, Gaithersburg, Maryland 20878, USA
    J Proteome Res 8:917-25. 2009
    ....
  37. ncbi Gene expression profiling of formalin-fixed, paraffin-embedded familial breast tumours using the whole genome-DASL assay
    Nic Waddell
    The Queensland Institute of Medical Research, Brisbane, Australia
    J Pathol 221:452-61. 2010
    ....
  38. ncbi Protein extraction of formalin-fixed, paraffin-embedded tissue enables robust proteomic profiles by mass spectrometry
    Marshall S Scicchitano
    Department of Safety Assessment, 709 Swedeland Road, Mail Stop UE0364, King of Prussia, PA 19406, USA
    J Histochem Cytochem 57:849-60. 2009
    ..These findings demonstrate that formalin fixation, paraffin processing, and LCM do not negatively impact protein quality and quantity as determined by MS and that FFPE samples are amenable to global proteomic analysis...
  39. ncbi Mortality among a cohort of garment workers exposed to formaldehyde: an update
    L E Pinkerton
    Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, The National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA
    Occup Environ Med 61:193-200. 2004
    To evaluate the mortality experience of 11 039 workers exposed to formaldehyde for three months or more in three garment plants. The mean time weighted average formaldehyde exposure at the plants in the early 1980s was 0...
  40. ncbi Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms
    Luoping Zhang
    School of Public Health, 50 University Hall, University of California, Berkeley, CA 94720 7356, USA
    Mutat Res 681:150-68. 2009
    b>Formaldehyde is an economically important chemical, to which more than 2 million U.S. workers are occupationally exposed...
  41. ncbi DNA extraction from archival formalin-fixed, paraffin-embedded tissue sections based on the antigen retrieval principle: heating under the influence of pH
    Shan-Rong Shi
    Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    J Histochem Cytochem 50:1005-11. 2002
    ..These findings may lead to a more effective protocol for DNA extraction from archival paraffin-embedded tissues and may also provide enhanced understanding of changes that occur during formalin-induced modification of nucleic acids...
  42. ncbi Social modulation of pain as evidence for empathy in mice
    Dale J Langford
    Department of Psychology and Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1, Canada
    Science 312:1967-70. 2006
    ..Finally, observation of a cagemate in pain altered pain sensitivity of an entirely different modality, suggesting that nociceptive mechanisms in general are sensitized...
  43. ncbi Equivalence of protein inventories obtained from formalin-fixed paraffin-embedded and frozen tissue in multidimensional liquid chromatography-tandem mass spectrometry shotgun proteomic analysis
    Robert W Sprung
    Jim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8575, USA
    Mol Cell Proteomics 8:1988-98. 2009
    ..No covalent peptide modifications attributable to formaldehyde chemistry were detected by analyses of the MS/MS datasets, which suggests that undetected, cross-linked ..
  44. ncbi Proteome analysis of microdissected formalin-fixed and paraffin-embedded tissue specimens
    Tong Guo
    Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland, USA
    J Histochem Cytochem 55:763-72. 2007
    ..This large degree of protein overlapping is attributed to the application of detergent-based protein extraction in both the cell pellet preparation protocol and the AR technique...
  45. ncbi Protein extraction from formalin-fixed, paraffin-embedded tissue sections: quality evaluation by mass spectrometry
    Shan Rong Shi
    Department of Pathology, University of Southern California Keck School of Medicine HMR 204, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    J Histochem Cytochem 54:739-43. 2006
    ....
  46. ncbi Proteome, phosphoproteome, and N-glycoproteome are quantitatively preserved in formalin-fixed paraffin-embedded tissue and analyzable by high-resolution mass spectrometry
    Paweł Ostasiewicz
    Department for Proteomics and Signal Transduction at Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
    J Proteome Res 9:3688-700. 2010
    ..Thus, FFPE biobank material can be analyzed by quantitative proteomics at the level of proteins and post-translational modifications...
  47. ncbi Development of a microarray platform for FFPET profiling: application to the classification of human tumors
    Sven Duenwald
    Translational Sciences, Department of Molecular Profiling, Merck Research Laboratories, Seattle, WA 98109, USA
    J Transl Med 7:65. 2009
    ..Methods are needed to profile these FFPET samples that are linked to clinical outcomes to generate hypotheses that could lead to classifiers for clinical applications...
  48. ncbi 'Tissue surrogates' as a model for archival formalin-fixed paraffin-embedded tissues
    Carol B Fowler
    Department of Biophysics, Armed Forces Institute of Pathology, Rockville, MD 20850, USA
    Lab Invest 87:836-46. 2007
    ..been hampered by inefficient methods to extract proteins from archival tissue and by an incomplete knowledge of formaldehyde-induced modifications in proteins...
  49. ncbi Whole genome amplification for array comparative genomic hybridization using DNA extracted from formalin-fixed, paraffin-embedded histological sections
    Jian Huang
    International Agency for Research on Cancer, Lyon, France
    J Mol Diagn 11:109-16. 2009
    ..0001). These results suggest that genetic analyses are possible using WGA-DNA extracted from paraffin sections, but that they should be performed with a carefully optimized and controlled protocol...
  50. ncbi Successful protein extraction from over-fixed and long-term stored formalin-fixed tissues
    Claudia Wolff
    Institute of Pathology, Technische Universitat Munchen, Munich, Germany
    PLoS ONE 6:e16353. 2011
    ..Because tissue fixation times vary in the routine clinical setting and pathology archives contain billions of FFPE tissues blocks, our data are highly relevant for research, diagnosis, and treatment of disease...
  51. ncbi Mining the archival formalin-fixed paraffin-embedded tissue proteome: opportunities and challenges
    Niroshini J Nirmalan
    Clinical and Biomedical Proteomics Group, Cancer Research UK Clinical Centre, St James s University Hospital, Beckett Street, Leeds, UK
    Mol Biosyst 4:712-20. 2008
    ..Here, we critically review the current status of research in the field, highlighting challenges which need to be addressed for robust quantitative application of protocols to ensure confident high impact inferences can be made...
  52. ncbi An array-based analysis of microRNA expression comparing matched frozen and formalin-fixed paraffin-embedded human tissue samples
    Xiao Zhang
    Department of Pathology and Molecular Medicine, Queen s Laboratory for Molecular Pathology, Kingston, ON, Canada
    J Mol Diagn 10:513-9. 2008
    ..669 to 0.815; Spearman rank correlation coefficient, 0.847 to 0.948), supporting the use of FFPE-derived miRNAs for array-based, gene expression profiling...
  53. ncbi Antigen retrieval for proteomic characterization of formalin-fixed and paraffin-embedded tissues
    Haifeng Xu
    Calibrant Biosystems, 910 Clopper Road, Suite 220N, Gaithersburg, Maryland 20878, USA
    J Proteome Res 7:1098-108. 2008
    ..Because single peptide hits are often regarded with skepticism, it is notable that all proteins tested by IHC stained positive...
  54. ncbi Reliability and reproducibility of PCR-based testing of O6-methylguanine-DNA methyltransferase gene (MGMT) promoter methylation status in formalin-fixed and paraffin-embedded neurosurgical biopsy specimens
    M Preusser
    Department of Internal Medicine I, Medical University, Austria
    Clin Neuropathol 27:388-90. 2008
    ..To analyze the reliability and reproducibility of PCR-based testing of O6-methylguanine-DNA methyltransferase gene (MGMT) promoter methylation status in formalin-fixed and paraffin-embedded (FFPE) neurosurgical biopsy specimens...
  55. ncbi Determination of N2-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following 13CD2-formaldehyde inhalation exposure
    Benjamin C Moeller
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599 7431, United States
    Chem Res Toxicol 24:162-4. 2011
    ..9 and 6.1 ppm of [(13)CD(2)]-formaldehyde for 6 h a day for 2 consecutive days was investigated using a highly sensitive nano-UPLC-MS/MS method with a ..
  56. ncbi Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde
    Fanxue Meng
    US Food and Drug Administration, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, Jefferson, AR 72079, USA
    Regul Toxicol Pharmacol 57:274-83. 2010
    This study examined the potential induction of tumor-associated mutations in formaldehyde-exposed rat nasal mucosa using a sensitive method, allele-specific competitive blocker-PCR (ACB-PCR)...
  57. ncbi Molecular dosimetry of N2-hydroxymethyl-dG DNA adducts in rats exposed to formaldehyde
    Kun Lu
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, United States
    Chem Res Toxicol 24:159-61. 2011
    ..7, 2, 5.8, 9.1, or 15.2 ppm [(13)CD(2)] formaldehyde for 6 h were quantified by a highly sensitive nano-UPLC-MS/MS method...
  58. ncbi Non-cancer effects of formaldehyde and relevance for setting an indoor air guideline
    Peder Wolkoff
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Environ Int 36:788-99. 2010
    There is considerable recent focus and concern about formaldehyde (FA). We have reviewed the literature on FA with focus on chemosensory perception in the airways and lung effects in indoor environments...
  59. ncbi Reversal of pathological pain through specific spinal GABAA receptor subtypes
    Julia Knabl
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, D 91054 Erlangen, Germany
    Nature 451:330-4. 2008
    ..These results provide a rational basis for the development of subtype-selective GABAergic drugs for the treatment of chronic pain, which is often refractory to classical analgesics...
  60. ncbi Housing characteristics and indoor concentrations of nitrogen dioxide and formaldehyde in Quebec City, Canada
    Nicolas L Gilbert
    Air Health Effects Division, Health Canada, 269 Laurier Avenue West, PL 4903B, Ottawa, Ontario, Canada K1A 0K9
    Environ Res 102:1-8. 2006
    Concentrations of nitrogen dioxide and formaldehyde were determined in a study of 96 homes in Quebec City, Canada, between January and April 2005...
  61. ncbi Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia
    Kun Lu
    Department of Environmental Sciences and Engineering, The University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 116:441-51. 2010
    Inhaled formaldehyde is classified as a known human and animal carcinogen, causing nasopharyngeal cancer. Additionally, limited epidemiological evidence for leukemia in humans is available; however, this is inconsistent across studies...
  62. ncbi Formaldehyde and leukemia: epidemiology, potential mechanisms, and implications for risk assessment
    Luoping Zhang
    School of Public Health, University of California, Berkeley, California 94720 7356, USA
    Environ Mol Mutagen 51:181-91. 2010
    b>Formaldehyde is widely used in the United States and other countries. Occupational and environmental exposures to formaldehyde may be associated with an increased risk of leukemia in exposed individuals...
  63. ncbi Exposure of human nasal epithelial cells to formaldehyde does not lead to DNA damage in lymphocytes after co-cultivation
    Simone Neuss
    Institut fur Humangenetik, Universitat Ulm, Ulm, Germany
    Mutagenesis 25:359-64. 2010
    ..with primary human nasal epithelial cells (HNEC) and isolated lymphocytes to investigate whether reactive formaldehyde (FA) can be passed on from nasal epithelial cells (site of first contact) to lymphocytes located in close ..
  64. ncbi Formaldehyde in China: production, consumption, exposure levels, and health effects
    Xiaojiang Tang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Environ Int 35:1210-24. 2009
    b>Formaldehyde, an economically important chemical, is classified as a human carcinogen that causes nasopharyngeal cancer and probably leukemia...
  65. ncbi Postmortem MRI of human brain hemispheres: T2 relaxation times during formaldehyde fixation
    Robert J Dawe
    Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois 60616, USA
    Magn Reson Med 61:810-8. 2009
    ..Five hemispheres immersed in formaldehyde solution were scanned on a weekly basis for 3 months postmortem, and once again at 6 months postmortem...
  66. ncbi Formaldehyde and cancer risk: a quantitative review of cohort studies through 2006
    C Bosetti
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Ann Oncol 19:29-43. 2008
    Occupational exposure to formaldehyde has been associated with excess risk of nasopharyngeal and selected other cancers.
  67. ncbi Occupational exposure to solvents and risk of non-Hodgkin lymphoma in Connecticut women
    Rong Wang
    Division of Environmental Health Sciences, Yale University School of Public Health, New Haven, Connecticut 06520 8034, USA
    Am J Epidemiol 169:176-85. 2009
    ..5, 95% CI: 1.1, 1.9). A borderline increased risk was also found for ever exposure to formaldehyde (OR = 1.3, 95% CI: 1.0, 1.7) in work settings. Risk of NHL increased with increasing average intensity (P = 0...
  68. ncbi Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers
    Simona Neumann
    Department of Anatomy and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 28:7936-44. 2008
    ....
  69. ncbi Reevaluation of mortality risks from leukemia in the formaldehyde cohort study of the National Cancer Institute
    Gary M Marsh
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Regul Toxicol Pharmacol 40:113-24. 2004
    To determine whether the National Cancer Institute's (NCI) recent suggestion of a causal association between formaldehyde exposure and mortality from leukemia and myeloid leukemia (ML) is robust with respect to alternative ..
  70. ncbi Extended follow-up of a cohort of british chemical workers exposed to formaldehyde
    David Coggon
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton, United Kingdom
    J Natl Cancer Inst 95:1608-15. 2003
    b>Formaldehyde is mutagenic and, when inhaled at high concentrations, carcinogenic in rats...
  71. ncbi Effect of duration of fixation on quantitative reverse transcription polymerase chain reaction analyses
    Maricris Macabeo-Ong
    Oral Pathology, Department of Stomatology, University of California San Francisco, California 94143-0424, USA
    Mod Pathol 15:979-87. 2002
    ..However, results for some markers are adversely affected by prolonged formalin fixation times...
  72. ncbi Formalin-induced changes of NMDA receptor subunit expression in the spinal cord of the rat
    C Gaunitz
    Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany
    Amino Acids 23:177-82. 2002
    ..In summary, the present data demonstrate adaptive changes in the NR subunit expression pattern in rat spinal cord due to formalin injection...
  73. ncbi Dosimetry modeling of inhaled formaldehyde: the human respiratory tract
    J H Overton
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 64:122-34. 2001
    b>Formaldehyde (HCHO), which has been shown to be a nasal carcinogen in rats and mice, is used widely and extensively in various manufacturing processes...
  74. ncbi Effects of different concentrations and volumes of formalin on pain response in rats
    I O Lee
    Department of Anesthesia, College of Medicine, Korea University, Seoul
    Acta Anaesthesiol Sin 38:59-64. 2000
    Formalin test is commonly used in animal model to assess injury-produced pain response. If the total amount of formaldehyde is fixed, its concentration and volume can be easily adjusted...
  75. ncbi An improved and cost-effective methodology for the reduction of autofluorescence in direct immunofluorescence studies on formalin-fixed paraffin-embedded tissues
    M S Viegas
    Molecular Pathology Laboratory, Portuguese Institute for Oncology of Coimbra IPOCFG EPE, Coimbra, Portugal
    Eur J Histochem 51:59-66. 2007
    ..In addition, we herein show that this methodology is highly effective in reducing autofluorescent background to levels that allow detection of specific signals by direct immunofluorescence...
  76. ncbi Methods comparison for high-resolution transcriptional analysis of archival material on Affymetrix Plus 2.0 and Exon 1.0 microarrays
    Kim Linton
    Cancer Research UK Department of Medical Oncology, the Christie NHS Foundation Trust, Manchester, UK
    Biotechniques 47:587-96. 2009
    ..While larger series are needed to confirm high correspondence between fresh-frozen and FFPE expression patterns, these data suggest that both Plus 2.0 and Exon arrays are suitable platforms for FFPE microarray expression analyses...
  77. ncbi Formaldehyde as a potential human leukemogen: an assessment of biological plausibility
    Robert Golden
    ToxLogic, Potomac, Maryland 20854, USA
    Crit Rev Toxicol 36:135-53. 2006
    The International Agency for Research on Cancer (IARC, 2004) recently reevaluated the epidemiological data on formaldehyde and concluded that there was "strong but not sufficient evidence for a causal association between leukaemia ..
  78. ncbi Accurate molecular characterization of formalin-fixed, paraffin-embedded tissues by microRNA expression profiling
    Anna E Szafranska
    Asuragen, Inc, 2150 Woodward Street, Suite 100, Austin, TX 78744, USA
    J Mol Diagn 10:415-23. 2008
    ....
  79. ncbi Inhaled formaldehyde: evaluation of sensory irritation in relation to carcinogenicity
    Josje H E Arts
    TNO Quality of Life, Zeist, P O Box 360, 3700 AJ Zeist, The Netherlands
    Regul Toxicol Pharmacol 44:144-60. 2006
    The critical health effects of formaldehyde exposure include sensory irritation and the potential to induce tumours in the upper respiratory tract. In literature, a concentration as low as 0...
  80. ncbi A review and meta-analysis of formaldehyde exposure and leukemia
    James J Collins
    Dow Chemical, 1803 Building, Midland, MI 48674, USA
    Regul Toxicol Pharmacol 40:81-91. 2004
    Most reviews on the carcinogenicity of formaldehyde have focused on cancers of the respiratory tract because these cancer sites were thought to be most biologically plausible...
  81. ncbi Reevaluation of mortality risks from nasopharyngeal cancer in the formaldehyde cohort study of the National Cancer Institute
    Gary M Marsh
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Regul Toxicol Pharmacol 42:275-83. 2005
    To determine whether the National Cancer Institute's (NCI) recent suggestion of a causal association between formaldehyde exposure and mortality from nasopharyngeal cancer (NPC) is robust with respect to alternative methods of data ..
  82. ncbi Cofactor-dependent pathways of formaldehyde oxidation in methylotrophic bacteria
    Julia A Vorholt
    Laboratoire de Biologie Moleculaire des relations Plantes Microorganismes, INRA CNRS, BP27, 31326 Castanet Tolosan, France
    Arch Microbiol 178:239-49. 2002
    ..These compounds are metabolized via the cytotoxin formaldehyde. The formaldehyde consumption pathways, especially the pathways for the oxidation of formaldehyde to CO(2) for ..
  83. ncbi Inhalation of formaldehyde does not induce systemic genotoxic effects in rats
    Günter Speit
    Universitat Ulm, Institut fur Humangenetik, D 89069 Ulm, Germany
    Mutat Res 677:76-85. 2009
    Male Fischer-344 rats were exposed to formaldehyde (FA) by inhalation for 4 weeks (6 h/day, 5 days/week). Groups of six rats each were exposed to the target concentrations of 0, 0.5, 1, 2, 6, 10 and 15 ppm...
  84. ncbi Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries
    Michael Hauptmann
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Natl Cancer Inst 95:1615-23. 2003
    Many U.S. factory workers are exposed to formaldehyde. Although increased risks for leukemia have been found in medical workers and other professionals exposed to formaldehyde, studies in industrial workers, who are thought to have higher ..
  85. ncbi Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells
    Luoping Zhang
    School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    Cancer Epidemiol Biomarkers Prev 19:80-8. 2010
    There are concerns about the health effects of formaldehyde exposure, including carcinogenicity, in light of elevated indoor air levels in new homes and occupational exposures experienced by workers in health care, embalming, ..
  86. ncbi Isolation of high quality protein samples from punches of formalin fixed and paraffin embedded tissue blocks
    J Kroll
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Histol Histopathol 23:391-5. 2008
    ..Interestingly, with this technique it is feasible to extract high quality proteins from 14 year old samples. In summary, the new technique makes a great pool of material now usable for molecular analysis with high throughput tools...
  87. ncbi Real-time quantitative RT-PCR shows variable, assay-dependent sensitivity to formalin fixation: implications for direct comparison of transcript levels in paraffin-embedded tissues
    Ina Koch
    Institutes of Pathology, Technical University of Munich, Munich, Germany
    Diagn Mol Pathol 15:149-56. 2006
    ..Thus, a standardized assessment of qRT-PCR assay efficiencies in FFPE allows for precise intraindividual comparison of mRNA species, such as splice variants with different biologic functions, in archival tissues...
  88. ncbi Effects of fixative type and fixation time on the detection of Maedi Visna virus by PCR and immunohistochemistry in paraffin-embedded ovine lung samples
    Julio Benavides
    , Facultad de Veterinaria, , Campus de Vegazana s/n, , Spain
    J Virol Methods 137:317-24. 2006
    ..Amplification of proviral DNA could not be obtained by PCR in these samples. IHC detected viral antigens in all sheep whereas one sheep with mild lesions was always negative by PCR...
  89. ncbi In situ detection of precursor and mature microRNAs in paraffin embedded, formalin fixed tissues and cell preparations
    Gerard J Nuovo
    Department of Pathology and the Comprehensive Cancer Center, Ohio State University Medical Center, 81 HLRI, 473 W 12th Avenue, Columbus, OH 43210, USA
    Methods 44:39-46. 2008
    ..Further, one can easily determine the specific subcellular compartmentalization of the precursor and mature forms which may provide insight into the modulation of these important regulatory molecules and their targets...
  90. ncbi Investigating fixative-induced changes in RNA quality and utility by microarray analysis
    Melissa L Cox
    Drug Safety, Pfizer Global Research and Development, Ann Arbor, MI, USA
    Exp Mol Pathol 84:156-72. 2008
    ....
  91. ncbi Exposure of nuclear antigens in formalin-fixed, paraffin-embedded necropsy human spinal cord tissue: detection of NeuN
    Sandeep K Gill
    Department of Physiology and Pharmacology, Medical Sciences Building, University of Western Ontario, London, Ont, Canada N6A 5C1
    J Neurosci Methods 148:26-35. 2005
    ..Auto-fluorescence in the tissue sections can be effectively reduced, but a sufficient fluorescence signal associated with specific antibody labeling could not be detected above this background for NeuN in the nucleus...
  92. ncbi Ultrasonic decalcification offers new perspectives for rapid FISH, DNA, and RT-PCR analysis in bone marrow trephines
    Tanja Reineke
    Institute of Surgical Pathology, University Hospital Zurich, Schmelsburgstrasse 12, CH-8091 Zurich, Switzerland
    Am J Surg Pathol 30:892-6. 2006
    ..In our hands, the combined use of ultrasound and ethylenediaminetetraacetate-based reagents permits successful interphase FISH, PCR, and RT-PCR analysis whereas concomitantly preserving morphology and antigeneicity...
  93. ncbi Cross-reactive antigenicity of nucleoproteins of lyssaviruses recognized by a monospecific antirabies virus nucleoprotein antiserum on paraffin sections of formalin-fixed tissues
    Satoshi Inoue
    Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo, Japan
    Pathol Int 53:525-33. 2003
    ....
  94. ncbi Hippocampal theta state in relation to formalin nociception
    Siew Kian Tai
    Department of Physiology (MD9, National University of Singapore, 2 Medical Drive, Singapore 117597, Singapore
    Pain 121:29-42. 2006
    ....
  95. ncbi Unravelling the proteome of formalin-fixed paraffin-embedded tissue
    Brian L Hood
    Laboratory of Proteomics and Analytical Technologies at SAIC-Frederick, Inc, MD 21702, USA
    Brief Funct Genomic Proteomic 5:169-75. 2006
    ..The ability to identify the proteins extracted from FFPE tissues allows comparative analyses that enable the potential discovery of novel biomarkers at the site of the diseased tissue...
  96. ncbi Dissociation of spinal microglia morphological activation and peripheral inflammation in inflammatory pain models
    Ting Lin
    Center for TMD and Orofacial Pain, Peking University School and Hospital of Stomatology, Beijing 100081, PR China
    J Neuroimmunol 192:40-8. 2007
    ..Although spinal microglia might be activated in inflammatory pain models, morphologically, spinal microglia activation was not closely correlated with peripheral inflammation...
  97. ncbi PCR-based diagnosis of Naegleria sp. infection in formalin-fixed and paraffin-embedded brain sections
    Marc Schild
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Bern, Switzerland
    J Clin Microbiol 45:564-7. 2007
    ....
  98. ncbi Gene expression patterns in formalin-fixed, paraffin-embedded core biopsies predict docetaxel chemosensitivity in breast cancer patients
    Jenny C Chang
    Breast Center and the Department of Medicine, Baylor College of Medicine and The Methodist Hospital, 1 Baylor Plaza, MS 600, Houston, TX 77030, USA
    Breast Cancer Res Treat 108:233-40. 2008
    ..008). We have established molecular profiles of sensitivity to docetaxel. RT-PCR technology provides a potential platform for a predictive test of docetaxel chemosensitivity using small amounts of routinely processed material...
  99. ncbi Optimized preservation of CNS morphology for the identification of glycogen in the Pompe mouse model
    Tatyana V Taksir
    Department of Pathology, Genzyme Corporation, One Mountain Road, Framingham, MA 01701 9322, USA
    J Histochem Cytochem 55:991-8. 2007
    ..The modified paraffin method with periodic acid postfixation resulted in improved tissue morphology and glycogen preservation. Both techniques provide accurate anatomic evaluation of the glycogen distribution in Pompe mouse brain...
  100. ncbi Formalin fixing and paraffin embedding may lead to extra band development in PCR
    O Cataloluk
    Gaziantep University, Faculty of Medicine, Department of Medical Biology and Genetics 27310, Kampus, Turkey
    New Microbiol 26:193-8. 2003
    ....
  101. ncbi Detection of bovine viral diarrhea virus in formalin fixed paraffin embedded tissue sections by real time RT-PCR (Taqman)
    Bodreddigari Bhudevi
    Animal Diagnostic Laboratory, Pennsylvania State University, University Park, PA 16802, USA
    J Virol Methods 109:25-30. 2003
    ..Real time RT-PCR improves diagnosis of BVD infection by allowing prospective and retrospective identification of BVD virus in tissues processed routinely and stored for histologic evaluation...

Research Grants79

  1. Nanopore Biosensor for Kinetics of Reparative Antibodies on Plasma Membranes
    Sang Hyun Oh; Fiscal Year: 2010
    ..Fixation of any kind (methanol, formaldehyde, freezing) destroys the complex membrane antigen...
  2. Innate immune evasion and/or antagonism by eastern equine encephalitis virus
    KATHERINE RYMAN; Fiscal Year: 2007
    ....
  3. True Direct Single Molecule RNA Sequencing
    PATRICE MARIE MILOS; Fiscal Year: 2010
    ....
  4. Developing an inactivated whole cell H. pylori vaccine
    GARY NABORS; Fiscal Year: 2006
    ..This trial will position the vaccine for more highly powered Phase 1 or early Phase 2 trials, and thus will move H. pylori vaccination one step closer to being a reality. ..
  5. Immunoprotective monoclonals to B. anthracis spores
    ALISON O BRIEN; Fiscal Year: 2003
    ..actually bind to the surface of spores and decrease the level of spore germination, taken with the fact that formaldehyde-inactivated spores can serve as a protective vaccine against anthrax in guinea pigs, led us to the following ..
  6. Molecular signatures of melanoma histology and progression: A Population Based A
    Abrar A Qureshi; Fiscal Year: 2010
    ..Thus we aim to significantly improve the current paradigm for diagnosis and therapy for melanoma by eventually reducing mortality from this deadly skin cancer. ..
  7. Molecular signatures of melanoma histology and progression: A Population Based A
    Abrar Qureshi; Fiscal Year: 2009
    ..Thus we aim to significantly improve the current paradigm for diagnosis and therapy for melanoma by eventually reducing mortality from this deadly skin cancer. ..
  8. Early Diagnosis of Oral Carcinoma Using Mutant PP32R1
    GERALD KOCHEVAR; Fiscal Year: 2006
    ..Identification of the intracellular protein ligands will provide a specific functional context for mutant PP32R1S. ..
  9. RSV Upper Airway Infection and Otitis Media
    JOAN E contact DURBIN; Fiscal Year: 2010
    ..Our group has found a new vaccine against this virus, and want to test whether immunity to RSV can protect against the process that causes bacterial ear infections. ..
  10. RSV Upper Airway Infection and Otitis Media
    Joan Durbin; Fiscal Year: 2009
    ..Our group has found a new vaccine against this virus, and want to test whether immunity to RSV can protect against the process that causes bacterial ear infections. ..
  11. PAIN, OPIOID ANALGESIA AND BLOOD PRESSURE CONTROL
    Bradley Taylor; Fiscal Year: 2002
    ..The results of these studies will facilitate our understanding of the mechanisms that contribute to chronic pain in the hypertensive patient. ..
  12. TUMOR MARKERS TO PREDICT TREATMENT RESPONSE
    Lynn Dressler; Fiscal Year: 2005
    ..Two subcontracts are included in this proposal, one to support the CALGB Pathology Coordinating Office functions at OSU relevant to this study and the other in support of the molecular studies being performed by USC. ..
  13. REGULATION OF C1 METABOLISM IN METHYLOTROPHS
    Mary Lidstrom; Fiscal Year: 2007
    ..A distinguishing feature of methylotrophic metabolism is the generation and consumption of formaldehyde as a central intermediate, the starting point for all of metabolism...
  14. Develop & Validate An Ultrasound Tissue Preservation De*
    Zhenqing Zhu; Fiscal Year: 2006
    ..Long-term stability of tissue morphology and mRNA integrity in USFFPE tissues is slightly better than that in conventional FFPE tissues. ..
  15. REGULATION OF C1 METABOLISM IN METHYLOTROPHS
    Mary Lidstrom; Fiscal Year: 2003
    ..From a cell biology perspective, their ability to funnel all of their cell carbon through a toxic intermediate (formaldehyde) make them of interest in terms of how they balance formaldehyde production and consumption under a wide regime ..