acrolein

Summary

Top Publications

  1. ncbi Formation of acrolein-derived 2'-deoxyadenosine adduct in an iron-induced carcinogenesis model
    Yoshichika Kawai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 278:50346-54. 2003
  2. ncbi Mechanisms of acrolein-induced myocardial dysfunction: implications for environmental and endogenous aldehyde exposure
    Jianzhu Luo
    Institute of Molecular Cardiology, Department of Medicine, University of Louisville, 550 South Jackson Street, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 293:H3673-84. 2007
  3. ncbi TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents
    Diana M Bautista
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 124:1269-82. 2006
  4. doi Role of by-products of lipid oxidation in Alzheimer's disease brain: a focus on acrolein
    Manjeet Singh
    INRS Institut Armand Frappier, Laval, PQ, Canada
    J Alzheimers Dis 21:741-56. 2010
  5. doi Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation
    Richard M LoPachin
    Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10467, USA
    Chem Res Toxicol 22:1499-508. 2009
  6. pmc Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid
    Lihong Jia
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Invest Ophthalmol Vis Sci 48:339-48. 2007
  7. ncbi Potential role of acrolein in neurodegeneration and in Alzheimer's disease
    Thanh Nam Dang
    INRS Institut Armand Frappier, 531, boul des Prairies, H7V 1B7 Laval, Quebec, Canada
    Curr Mol Pharmacol 3:66-78. 2010
  8. doi Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells
    Julie Roy
    Departement des Sciences Biologiques, TOXEN, Universite du Quebec a Montreal, Succursale Centre Ville, Canada
    Chem Biol Interact 181:154-67. 2009
  9. pmc CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure
    Michael T Borchers
    Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA
    Exp Mol Pathol 83:301-10. 2007
  10. pmc Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production
    Hitesh S Deshmukh
    Center for Environmental Genetics, University of Cincinnati, Cincinnati, USA
    Am J Respir Cell Mol Biol 38:446-54. 2008

Research Grants

Detail Information

Publications285 found, 100 shown here

  1. ncbi Formation of acrolein-derived 2'-deoxyadenosine adduct in an iron-induced carcinogenesis model
    Yoshichika Kawai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 278:50346-54. 2003
    b>Acrolein is a representative carcinogenic aldehyde found ubiquitously in the environment and formed endogenously through oxidation reactions, such as lipid peroxidation and myeloperoxidase-catalyzed amino acid oxidation...
  2. ncbi Mechanisms of acrolein-induced myocardial dysfunction: implications for environmental and endogenous aldehyde exposure
    Jianzhu Luo
    Institute of Molecular Cardiology, Department of Medicine, University of Louisville, 550 South Jackson Street, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 293:H3673-84. 2007
    ..Accordingly, we examined the myocardial effects of the model unsaturated aldehyde acrolein. In closed-chest mice, intravenous acrolein (0...
  3. ncbi TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents
    Diana M Bautista
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 124:1269-82. 2006
    ..TRPA1 is also targeted by environmental irritants, such as acrolein, that account for toxic and inflammatory actions of tear gas, vehicle exhaust, and metabolic byproducts of ..
  4. doi Role of by-products of lipid oxidation in Alzheimer's disease brain: a focus on acrolein
    Manjeet Singh
    INRS Institut Armand Frappier, Laval, PQ, Canada
    J Alzheimers Dis 21:741-56. 2010
    ..formation of a number of aldehydes by-products, including malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), and acrolein. The most abundant aldehydes are HNE and MDA while acrolein is the most reactive...
  5. doi Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation
    Richard M LoPachin
    Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10467, USA
    Chem Res Toxicol 22:1499-508. 2009
    b>Acrolein and 4-hydroxy-2-nonenal (HNE) are byproducts of lipid peroxidation and are thought to play central roles in various traumatic injuries and disease states that involve cellular oxidative stress, for example, spinal cord trauma, ..
  6. pmc Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid
    Lihong Jia
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Invest Ophthalmol Vis Sci 48:339-48. 2007
    ..cigarette smoke, oxidant injury, and age-associated macular degeneration, the authors examined the effects of acrolein, a major toxicant in cigarette smoke, on oxidative mitochondrial damage in retinal pigment epithelial (RPE) cells ..
  7. ncbi Potential role of acrolein in neurodegeneration and in Alzheimer's disease
    Thanh Nam Dang
    INRS Institut Armand Frappier, 531, boul des Prairies, H7V 1B7 Laval, Quebec, Canada
    Curr Mol Pharmacol 3:66-78. 2010
    Lipid peroxidation leads to the formation of a number of aldehydes by-products, including acrolein. The most abundant aldehydes are 4-hydroxy-nonenal (4-HNE) and malondialdehyde (MDA) while acrolein is the most reactive...
  8. doi Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells
    Julie Roy
    Departement des Sciences Biologiques, TOXEN, Universite du Quebec a Montreal, Succursale Centre Ville, Canada
    Chem Biol Interact 181:154-67. 2009
    b>Acrolein is a highly reactive, alpha,beta-unsaturated aldehyde that is an omnipresent environmental pollutant. Humans are exposed to acrolein in food, vapors of overheated cooking oil, cigarette smoke and by combustion of organic products...
  9. pmc CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure
    Michael T Borchers
    Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA
    Exp Mol Pathol 83:301-10. 2007
    ..In this study, we utilize a mouse model of COPD to examine the contributions of CD8(+) T cells in the persistent macrophage accumulation and airspace enlargement resulting from chronic irritant exposure...
  10. pmc Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production
    Hitesh S Deshmukh
    Center for Environmental Genetics, University of Cincinnati, Cincinnati, USA
    Am J Respir Cell Mol Biol 38:446-54. 2008
    ..b>Acrolein, a constituent of cigarette smoke and an endogenous mediator of oxidative stress, increases airway mucin 5, ..
  11. pmc Role of endoplasmic reticulum stress in acrolein-induced endothelial activation
    Petra Haberzettl
    Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Toxicol Appl Pharmacol 234:14-24. 2009
    b>Acrolein is a ubiquitous environmental pollutant and an endogenous product of lipid peroxidation. It is also generated during the metabolism of several drugs and amino acids...
  12. pmc Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts
    Giorgia Volpi
    Department of Pharmacology, Chiesi Farmaceutici s p a, Parma, Italy
    Br J Pharmacol 163:649-61. 2011
    ..The aim of this study was to investigate whether acute exposure to cigarette smoke extract altered VEGF production in lung parenchymal cells...
  13. ncbi Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G2/M phase
    Ha Won Jeong
    Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosunggu, Taejeon 305 600, South Korea
    Biochem Pharmacol 65:1343-50. 2003
    ..These results support the hypothesis that the cinnamaldehyde derivative CB403 exerts cytostatic properties by inducing mitotic arrest in cancer cells...
  14. ncbi Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
    Michael Bandell
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Neuron 41:849-57. 2004
    ..Collectively, these data demonstrate that TRPA1 activation elicits a painful sensation and provide a potential molecular model for why noxious cold can paradoxically be perceived as burning pain...
  15. doi Cinnamaldehyde inhibits the tumor necrosis factor-alpha-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-kappaB activation: effects upon IkappaB and Nrf2
    Being Chyuan Liao
    Department of Microbiology and Immunology, National Chiayi University, Chiayi, Taiwan
    Toxicol Appl Pharmacol 229:161-71. 2008
    ..Hence, our present findings indicate that cinnamaldehyde suppresses TNF-induced singling pathways via two distinct mechanisms that are activated by different pretreatment periods...
  16. ncbi Cinnamaldehyde induces endothelium-dependent and -independent vasorelaxant action on isolated rat aorta
    Ayano Yanaga
    Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama, Japan
    Biol Pharm Bull 29:2415-8. 2006
    ..Endothelium-dependent relaxation is affected by nitric oxide, and one of the mechanisms of endothelium-independent relaxation is thought to be influenced by the blocking of Ca2+ channels...
  17. pmc TRPA1 agonists evoke coughing in guinea pig and human volunteers
    Mark A Birrell
    Respiratory Pharmacology Group, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Am J Respir Crit Care Med 180:1042-7. 2009
    ..Environmental irritants such as air pollution and cigarette smoke are thought to evoke cough by stimulating airway sensory nerves; however, how this occurs is not fully understood...
  18. ncbi Cinnamaldehyde--a potential antidiabetic agent
    P Subash Babu
    Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, Tamil Nadu, India
    Phytomedicine 14:15-22. 2007
    ..05) reduction in blood glucose concentration in STZ-induced diabetic rats. The results of this experimental study indicate that cinnamaldehyde possesses hypoglycemic and hypolipidemic effects in STZ-induced diabetic rats...
  19. pmc Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke
    S Patrick Nana-Sinkam
    The Ohio State University, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, 201 Davis Heart and Lung Research Institute, 473 West 12th Avenue, Columbus, OH 43210, USA
    Am J Respir Crit Care Med 175:676-85. 2007
    ..Prostacyclin (PGI(2)) is a major product of the cyclooxygenase pathway with potent vasodilatory and antimitogenic properties and may be relevant to endothelial dysfunction in COPD...
  20. ncbi Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease
    Taufika Islam Williams
    Department of Chemistry, University of Kentucky, 135 Sanders Brown Center on Aging, Lexington, KY 40506, USA
    Neurobiol Aging 27:1094-9. 2006
    ..of lipid peroxidation and neurotoxic by-products of lipid peroxidation including 4-hydroxynonenal (HNE) and acrolein in vulnerable regions of the Alzheimer's disease (AD) brain...
  21. ncbi Regulation of constitutive neutrophil apoptosis by the alpha,beta-unsaturated aldehydes acrolein and 4-hydroxynonenal
    Erik I Finkelstein
    Dept of Pathology, College of Medicine, University of Vermont, 89 Beaumont Ave Burlington, VT 05405, USA
    Am J Physiol Lung Cell Mol Physiol 289:L1019-28. 2005
    ..induce apoptotic cell death in various cell types, we recently observed that the alpha,beta-unsaturated aldehyde acrolein (ACR) can inhibit constitutive apoptosis of polymorphonuclear neutrophils and thus potentially contribute to ..
  22. pmc Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease
    Jan F Stevens
    Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR, USA
    Mol Nutr Food Res 52:7-25. 2008
    b>Acrolein (2-propenal) is ubiquitously present in (cooked) foods and in the environment...
  23. ncbi Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein
    Jeffry D Schroeter
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
    Inhal Toxicol 20:227-43. 2008
    b>Acrolein is a highly soluble and reactive aldehyde and is a potent upper-respiratory-tract irritant...
  24. ncbi Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein
    Mi Kyoung Kwak
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 305:662-70. 2003
    ..by spermidine treatment, but could be inhibited by the amine oxidase inhibitor, aminoguanidine, suggesting that acrolein or hydrogen peroxide generated from polyamines by serum amine oxidase may be mediators for phase 2 enzyme ..
  25. doi Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention
    Eng Hui Chew
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore 117543
    Free Radic Biol Med 48:98-111. 2010
    ..These Michael acceptor molecules can potentially be exploited for use in different concentrations in chemotherapeutic and chemopreventive strategies...
  26. doi A possible role of acrolein in diabetic retinopathy: involvement of a VEGF/TGFβ signaling pathway of the retinal pigment epithelium in hyperglycemia
    Jeffery Grigsby
    University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA
    Curr Eye Res 37:1045-53. 2012
    b>Acrolein has been implicated in retinal pigment epithelium (RPE) cell death, and has been associated with diabetic retinopathy...
  27. pmc Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR
    Gilles Brackman
    Laboratory of Pharmaceutical Microbiology, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    BMC Microbiol 8:149. 2008
    ..The compounds were also evaluated in an in vivo assay measuring the reduction of Vibrio harveyi virulence towards Artemia shrimp...
  28. doi Genome-wide transcriptional responses to acrolein
    Colin A Thompson
    Pharmacology and Anaesthesiology Unit, School of Medicine and Pharmacology, The University of Western Australia, Perth WA 6009, Australia
    Chem Res Toxicol 21:2245-56. 2008
    The lipid peroxidation product and environmental pollutant acrolein participates in many diseases...
  29. pmc Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathy
    Mohamed Ameen Ismahil
    Department of Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 301:H2050-60. 2011
    Environmental triggers of dilated cardiomyopathy are poorly understood. Acute exposure to acrolein, a ubiquitous aldehyde pollutant, impairs cardiac function and cardioprotective responses in mice...
  30. doi Melatonin suppresses acrolein-induced IL-8 production in human pulmonary fibroblasts
    Gun Dong Kim
    Department of Microbiology BK21, School of Medicine, Kyung Hee University, Hoegi dong, Seoul, Korea
    J Pineal Res 52:356-64. 2012
    ..Furthermore, recent studies show that, α, β-unsaturated aldehyde acrolein in CS induces the production of interleukin (IL)-8, which is known to be related to bronchitis, rhinitis, ..
  31. doi Effects of nitric oxide on the primary bladder afferent activities of the rat with and without intravesical acrolein treatment
    Naoki Aizawa
    Department of Urology, Faculty of Medicine, University of Antwerp, Antwerp, Belgium
    Eur Urol 59:264-71. 2011
    It has been suggested that nitric oxide (NO) affects the afferent pathways innervating the bladder. In addition, acrolein, a metabolite of cyclophosphamide, causes bladder hypersensitivity in rats.
  32. ncbi Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal
    M L Iersel
    Department of Toxicology, Wageningen Agricultural University, Netherlands
    Chem Biol Interact 102:117-32. 1996
    ..The reactive acrolein did not inhibit the DNPSG-excretion at 2.5 microM, the highest non-toxic concentration...
  33. doi Natural polyphenols as direct trapping agents of lipid peroxidation-derived acrolein and 4-hydroxy-trans-2-nonenal
    Qin Zhu
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, PR China
    Chem Res Toxicol 22:1721-7. 2009
    b>Acrolein (ACR) and 4-hydroxy-trans-2-nonenal (HNE) are two cytotoxic lipid-derived alpha,beta-unsaturated aldehydes which have been implicated as causative agents in the development of carbonyl stress-associated pathologies...
  34. ncbi 2-hydroxycinnamaldehyde inhibits SW620 colon cancer cell growth through AP-1 inactivation
    Chung Woo Lee
    College of Pharmacy, Chungbuk National University, Korea
    J Pharmacol Sci 104:19-28. 2007
    ..These results suggested that HCA has the most potent inhibitory effect against human colon cancer cell growth, and AP-1 may be an important target of HCA...
  35. doi Simvastatin attenuates acrolein-induced mucin production in rats: involvement of the Ras/extracellular signal-regulated kinase pathway
    Ya Juan Chen
    Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
    Int Immunopharmacol 10:685-93. 2010
    ..cellular functions in the lung, we sought to investigate whether the Ras inhibitor simvastatin could attenuate acrolein-induced mucin production in rat airways...
  36. pmc Acrolein inhalation prevents vascular endothelial growth factor-induced mobilization of Flk-1+/Sca-1+ cells in mice
    Laura A Wheat
    Diabetes and Obesity Center, Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40292, USA
    Arterioscler Thromb Vasc Biol 31:1598-606. 2011
    b>Acrolein is a toxic chemical present in tobacco, wood, and coal smoke, as well as automobile exhaust...
  37. ncbi Increase in putrescine, amine oxidase, and acrolein in plasma of renal failure patients
    Kaori Sakata
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
    Biochem Biophys Res Commun 305:143-9. 2003
    ..been suggested to be one of the uremic "toxins," the levels of each polyamine, its oxidized product, acrolein, and amine oxidase in plasma of patients with renal failure were investigated...
  38. doi Acrolein sequestering ability of the endogenous tripeptide glycyl-histidyl-lysine (GHK): characterization of conjugation products by ESI-MSn and theoretical calculations
    Giangiacomo Beretta
    Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, University of Milan, Faculty of Pharmacy, Via Mangiagalli 25, 20133 Milan, Italy
    J Pharm Biomed Anal 47:596-602. 2008
    b>Acrolein (ACR) is a well-known carbonyl toxin produced by lipid peroxidation of polyunsaturated fatty acids, which is involved in several life-threatening pathologies such as Alzheimer disease, arteriosclerosis, diabetes, and nephropathy...
  39. ncbi Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein
    Larry G Higgins
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, UK
    Toxicol Appl Pharmacol 226:328-37. 2008
    ..Priming of nrf2(+/+) MEFs, but not nrf2(-/-) MEFs, with C+K conferred 2-fold resistance towards acrolein.
  40. ncbi Reduced 293T cell susceptibility to acrolein due to aldose reductase-like-1 protein expression
    Xuyu Zu
    Department of Medical Microbiology, Immunology, and Cell Biology, SimmonsCooper Cancer Institute, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
    Toxicol Sci 97:562-8. 2007
    b>Acrolein is a highly reactive alpha,beta-unsaturated aldehyde produced endogenously during lipid peroxidation and naturally distributed pervasively in living environments, posing serious threats to human health if not properly metabolized...
  41. doi Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCepsilon signaling and cardioprotection
    Guang Wu Wang
    Department of Physiology and the Cardiovascular Research Laboratories, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Mol Cell Cardiol 44:1016-22. 2008
    ..Mice were gavage-fed the alpha, beta-unsaturated aldehyde acrolein (5mg/kg) or water (vehicle) 24h prior to a 30-min coronary artery occlusion and 24-hour reperfusion...
  42. ncbi The molecular effects of acrolein
    J P Kehrer
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    Toxicol Sci 57:6-15. 2000
    b>Acrolein is a highly electrophilic alpha,beta-unsaturated aldehyde to which humans are exposed in a variety of environmental situations, particularly as a component of smoke...
  43. doi α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells
    Zhihui Feng
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Nutr Biochem 21:1222-31. 2010
    ..We investigated α-tocopherol's inducing effect on Phase II enzymes and its protective effect on acrolein-induced toxicity in a human retinal pigment epithelial (RPE) cell line, ARPE-19...
  44. pmc Critical role of acrolein in secondary injury following ex vivo spinal cord trauma
    Kristin Hamann
    Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Neurochem 107:712-21. 2008
    ..The lipid peroxidation byproduct acrolein has been implicated as one potential mediator of secondary injury...
  45. ncbi Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction
    Nikolay Vasilyev
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Circulation 112:2812-20. 2005
    ..However, a role for MPO in formation of aldehydes in vivo and the functional consequences of MPO-generated oxidants in ischemia/reperfusion models of MI have not been established...
  46. ncbi Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells
    Hyeon Ka
    College of Pharmacy, Kyung Hee University, Hoegi dong, Dongdaemun ku, Seoul 130 701, South Korea
    Cancer Lett 196:143-52. 2003
    ..This is the first report on the mechanism of the anticancer effect of cinnamaldehyde...
  47. ncbi Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal
    Subbiah Pugazhenthi
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Free Radic Biol Med 40:21-34. 2006
    ..AD), oxidative stress-induced lipid peroxidation leads to accumulation of unsaturated aldehydes including acrolein and 4-hydroxynonenal (4HNE) in brain...
  48. ncbi The cigarette smoke component acrolein inhibits expression of the innate immune components IL-8 and human beta-defensin 2 by sinonasal epithelial cells
    Won Kyung Lee
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
    Am J Rhinol 21:658-63. 2007
    ..b>Acrolein (AC) is a major component of cigarette smoke that has been shown to suppress innate immune gene expression by ..
  49. pmc Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice
    Sanjay Srivastava
    Diabetes and Obesity Center, University of Louisville, Louisville, KY 40202, USA
    Atherosclerosis 215:301-8. 2011
    b>Acrolein is a dietary aldehyde that is present in high concentrations in alcoholic beverages and foods including cheese, donuts and coffee...
  50. doi Doxycycline attenuates acrolein-induced mucin production, in part by inhibiting MMP-9
    Shuang Ren
    Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, China
    Eur J Pharmacol 650:418-23. 2011
    ..have been found to increase the expression of epidermal growth factor (EGF) receptor, a possible regulator of acrolein-induced mucin expression in the airway epithelium...
  51. ncbi Effects of cinnamaldehyde on PGE2 release and TRPV4 expression in mouse cerebral microvascular endothelial cells induced by interleukin-1beta
    Yue ying Ma
    Tang Center for Herbal Medicine Research, Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China
    Biol Pharm Bull 31:426-30. 2008
    ..End3 cells. In conclusion, cinnamaldehyde decreased the production of PGE2 and the expression of TRPV4 in b.End3 cells induced by IL-1beta...
  52. pmc Quantitation of acrolein-derived (3-hydroxypropyl)mercapturic acid in human urine by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: effects of cigarette smoking
    Steven G Carmella
    The Cancer Center and Transdisciplinary Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:986-90. 2007
    Recently published data suggest that acrolein (1), a toxic but weakly carcinogenic constituent of cigarette smoke, may be involved as a causative factor for the mutations frequently observed in the p53 tumor suppressor gene in lung cancer ..
  53. ncbi Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures
    M A Lovell
    Sanders-Brown Center on Aging and Alzheimer's Disease Research Center, 101 Sanders-Brown Building, University of Kentucky, 800 South Limestone Street, Lexington, KY 40536-0230, USA
    Neurobiol Aging 22:187-94. 2001
    ..b>Acrolein, an alpha,beta-unsaturated aldehydic product of lipid peroxidation, is approximately 100 times more reactive than ..
  54. ncbi Acrolein induces Hsp72 via both PKCdelta/JNK and calcium signaling pathways in human umbilical vein endothelial cells
    Yoshiko Misonou
    Department of Biochemistry, Osaka University Graduate School of Medicine, B1, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Free Radic Res 39:507-12. 2005
    b>Acrolein is a highly electrophilic alpha,beta-unsaturated aldehydes to which humans are exposed in a variety of environment situations and is also a product of lipid peroxidation...
  55. pmc Acrolein induces selective protein carbonylation in synaptosomes
    C F Mello
    Department of Chemistry, Center of Membrane Sciences and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA
    Neuroscience 147:674-9. 2007
    b>Acrolein, the most reactive of the alpha,beta-unsaturated aldehydes, is endogenously produced by lipid peroxidation, and has been found increased in the brain of patients with Alzheimer's disease...
  56. doi Intense correlation between protein-conjugated acrolein and primary Sjögren's syndrome
    Kyohei Higashi
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Clin Chim Acta 411:359-63. 2010
    We recently found that an increased plasma concentration of protein-conjugated acrolein is a good biomarker for stroke...
  57. ncbi Acute acrolein-induced cystitis in mice
    Dale E Bjorling
    Department of Surgical Sciences, School of Veterinary, University of Wisconsin, Madison, WI 53706, USA
    BJU Int 99:1523-9. 2007
    To develop a method of direct intravesical administration of acrolein and evaluate the severity of cystitis in response to increasing doses of acrolein in female C57BL/6N (C57) mice, with further studies to compare the severity of acute ..
  58. doi Modulation of hydrogen peroxide and acrolein-induced oxidative stress, mitochondrial dysfunctions and redox regulated pathways by the Bacopa monniera extract: potential implication in Alzheimer's disease
    Manjeet Singh
    INRS Institut Armand Frappier, Laval, PQ, Canada
    J Alzheimers Dis 21:229-47. 2010
    b>Acrolein is one of the by-products of lipid peroxidation. Due to its high reactivity, it is not only a marker of lipid peroxidation but could also be an initiator of oxidative stress by adducting cellular nucleophilic groups...
  59. ncbi Detoxication of the environmental pollutant acrolein by a rat liver aldo-keto reductase
    Rachel Gardner
    Departments of Bioscience and Pharmaceutical Sciences, Royal College, University of Strathclyde, 204, George Street, Glasgow G1 1XW, Scotland, UK
    Toxicol Lett 148:65-72. 2004
    b>Acrolein is a highly reactive hazardous air pollutant of human health concern, particularly as it is a component of cigarette smoke. It can be metabolized by enzymes including the aldo-keto reductase (AKR) family of enzymes...
  60. pmc Acrolein consumption induces systemic dyslipidemia and lipoprotein modification
    DANIEL J CONKLIN
    Diabetes and Obesity Center, University of Louisville, Louisville, KY 40202, USA
    Toxicol Appl Pharmacol 243:1-12. 2010
    Aldehydes such as acrolein are ubiquitous pollutants present in automobile exhaust, cigarette, wood, and coal smoke...
  61. ncbi Relationships between cell density, glutathione and proliferation of A549 human lung adenocarcinoma cells treated with acrolein
    N D Horton
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin 78712 1074, USA
    Toxicology 122:111-22. 1997
    b>Acrolein is a highly electrophilic alpha,beta-unsaturated aldehyde to which humans are exposed in various situations. Acrolein reacts rapidly with and depletes cellular glutathione (GSH), and is toxic to various types of cells...
  62. doi Acrolein health effects
    O Faroon
    ATSDR, Division of Toxicology and Environmental Medicine, Atlanta, Georgia, USA
    Toxicol Ind Health 24:447-90. 2008
    b>Acrolein is a chemical used as an intermediate reactive aldehyde in chemical industry. It is used for synthesis of many organic substances, methionine production, and methyl chloride refrigerant...
  63. doi Inhibitory effects of phosphodiesterase 5 inhibitor, tadalafil, on mechanosensitive bladder afferent nerve activities of the rat, and on acrolein-induced hyperactivity of these nerves
    Tomonori Minagawa
    Department of Urology, Antwerp University Hospital and Antwerp University, Faculty of Medicine, Antwerp, Belgium
    BJU Int 110:E259-66. 2012
    ..One of the mechanisms of tadalafil on LUTS is added in the study...
  64. ncbi Attenuation of mouse somatic and emotional inflammatory pain by hydralazine through scavenging acrolein and inhibiting neuronal activation
    Lu Bai
    Department of Anatomy and K K Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, China
    Pain Physician 15:311-26. 2012
    b>Acrolein signaling is important during spinal cord injury; whether it is involved in somatic and emotional pain is not clear. Hydralazine is a potent antihypertensive drug and can scavenge acrolein efficiently.
  65. doi Yap1 activation by H2O2 or thiol-reactive chemicals elicits distinct adaptive gene responses
    Xiaoguang Ouyang
    Department of Biological Sciences and W Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, TN 38152 3560, USA
    Free Radic Biol Med 50:1-13. 2011
    ..N-ethylmaleimide (NEM) showed no cross-protection against each other, whereas another thiol-reactive chemical, acrolein, elicited Yap1-dependent cross-protection against NEM, but not H(2)O(2)...
  66. doi Acrolein, IL-6 and CRP as markers of silent brain infarction
    Madoka Yoshida
    Chiba University, Inohana, Chuo Ku, Japan
    Atherosclerosis 203:557-62. 2009
    ..increased levels of polyamine oxidase (PAO) [acetylpolyamine oxidase (AcPAO) plus spermine oxidase (SMO)], and acrolein (CH(2)CHCHO) are good markers of stroke...
  67. ncbi Acrolein-induced cytotoxicity in cultured human bronchial epithelial cells. Modulation by alpha-tocopherol and ascorbic acid
    Mirella Nardini
    Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Via Ardeatina 546, 00178, Rome, Italy
    Toxicology 170:173-85. 2002
    b>Acrolein is a highly reactive unsaturated hazardous air pollutant of human health concern, particularly as a component of cigarette smoke...
  68. doi Functionalized mesoporous silica nanoparticle-based drug delivery system to rescue acrolein-mediated cell death
    Youngnam Cho
    Purdue University, Center for Paralysis Research, School of Veterinary Medicine, West Lafayette, IN 47907, USA
    Nanomedicine (Lond) 3:507-19. 2008
    ..These agents restore damaged cell membranes and ameliorate abnormal mitochondria behavior induced by the endogenous toxin acrolein. Such a formulation shows potential as a novel therapeutic agent.
  69. pmc Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction
    Zhongbo Liu
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Neurochem 103:2690-700. 2007
    ..In the present study, we investigated the protective effects of HTS on acrolein-induced toxicity in human retinal pigment epithelial cell line, ARPE-19, a cellular model of smoking- and age-..
  70. ncbi Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease
    Chava B Pocernich
    Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA
    Neurotox Res 5:515-20. 2003
    ..and linoleic acids, precursors of lipid peroxidation products, 4-hydroxynonenal (HNE) and 2-propen-1-al (acrolein), that are extremely reactive. Both alkenals are increased in AD brain...
  71. doi Upregulation of cellular glutathione by 3H-1,2-dithiole-3-thione as a possible treatment strategy for protecting against acrolein-induced neurocytotoxicity
    Zhenquan Jia
    Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, 2265 Kraft Drive, Blacksburg, VA 24060, USA
    Neurotoxicology 30:1-9. 2009
    b>Acrolein, an unsaturated aldehydic product of lipid peroxidation, has been implicated in the pathogenesis of various neurodegenerative disorders including Parkinson's disease...
  72. doi Acrolein - a pulmonary hazard
    Kiflai Bein
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Mol Nutr Food Res 55:1342-60. 2011
    b>Acrolein is a respiratory irritant that can be generated during cooking and is in environmental tobacco smoke...
  73. ncbi Origin, occurrence, and source emission rate of acrolein in residential indoor air
    Vincent Y Seaman
    Department of Environmental Toxicology, University of California, Davis, California, USA
    Environ Sci Technol 41:6940-6. 2007
    b>Acrolein, a volatile, unsaturated aldehyde, is a known respiratory toxicant and one of the 188 most hazardous air pollutants identified by the U.S. EPA...
  74. ncbi Characterization of acrolein-induced protein cross-links
    Takeshi Ishii
    Department of Food and Nutritional Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Free Radic Res 41:1253-60. 2007
    ..b>Acrolein (ACR), a highly toxic lipid peroxidation aldehyde, is a strong cross-linking agent of cellular components such as ..
  75. ncbi The concept of "aldehyde load" in neurodegenerative mechanisms: cytotoxicity of the polyamine degradation products hydrogen peroxide, acrolein, 3-aminopropanal, 3-acetamidopropanal and 4-aminobutanal in a retinal ganglion cell line
    Paul L Wood
    The Falk Center for Molecular Therapeutics, Dept of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, 1801 Maple Ave, Suite 4306, Evanston, IL 60201, USA
    Brain Res 1145:150-6. 2007
    ..The major aldehydes produced by polyamine oxidase and amine oxidases include the 2-alkenal acrolein, the acetoamidoaldehyde 3-acetamidopropanal (3-AAP) and the aminoaldehydes 3-aminopropanal (3-AP) and 4-..
  76. pmc Analysis of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human leukocyte DNA from smokers and nonsmokers
    Siyi Zhang
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 24:119-24. 2011
    Cigarette smoking is a major source of human exposure to acrolein, a widespread environmental pollutant and toxicant that is also formed endogenously through metabolism of amino acids and polyamines and lipid peroxidation...
  77. ncbi Acrolein produces nitric oxide through the elevation of intracellular calcium levels to induce apoptosis in human umbilical vein endothelial cells: implications for smoke angiopathy
    Yoshiko Misonou
    Department of Biochemistry, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nitric Oxide 14:180-7. 2006
    b>Acrolein is a highly electrophilic alpha, beta-unsaturated aldehyde, the levels of which are increased in the blood of smokers...
  78. doi Characterization of adducts formed in reactions of acrolein with thymidine and calf thymus DNA
    Agnieszka J Pawłowicz
    Laboratory of Organic Chemistry, Abo Akademi University, Biskopsgatan 8, FIN 20500 Turku Abo
    Chem Biodivers 5:177-88. 2008
    b>Acrolein, an important industrial chemical and environmental contaminant, has been shown to interact with nucleic acids in vitro and in vivo...
  79. ncbi Immunohistochemical detection of lipid peroxidation products, protein-bound acrolein and 4-hydroxynonenal protein adducts, in actinic elastosis of photodamaged skin
    N Tanaka
    Department of Dermatology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Arch Dermatol Res 293:363-7. 2001
    b>Acrolein and 4-hydroxy-2-nonenal (HNE) are both byproducts of a lipid peroxidation reaction...
  80. doi Toxicity of smoke extracts towards A549 lung cells: role of acrolein and suppression by carbonyl scavengers
    Philip C Burcham
    Pharmacology and Anaesthesiology Unit, School of Medicine and Pharmacology, The University of Western Australia, Nedlands, WA 6009, Australia
    Chem Biol Interact 183:416-24. 2010
    The noxious 3-carbon electrophile acrolein forms on combustion of diverse organic matter including synthetic polymers such as polyethylene...
  81. doi Towards the sustainable production of acrolein by glycerol dehydration
    Benjamin Katryniok
    Universite des Sciences et Technologies de Lille, UMR, CNRS, Villeneuve d Ascq, France
    ChemSusChem 2:719-30. 2009
    ..Glycerol dehydration to acrolein over acid catalysts is one of the most promising ways of valorization, because this compound is an important ..
  82. doi Acrolein: unwanted side product or contribution to antiangiogenic properties of metronomic cyclophosphamide therapy?
    M Gunther
    Pharmaceutical Biology Biotechnology, Department of Pharmacy, Ludwig Maximilians Universitat, Butenandtstr, Munich, Germany
    J Cell Mol Med 12:2704-16. 2008
    ..We have studied potential antiangiogenic properties of acrolein which is released from CPA after hydroxylation...
  83. ncbi Acrolein produced from polyamines as one of the uraemic toxins
    K Sakata
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
    Biochem Soc Trans 31:371-4. 2003
    ..Among the products, we found that acrolein is a major toxic compound produced from spermine and spermidine by amine oxidase...
  84. pmc Solution structure of DNA containing alpha-OH-PdG: the mutagenic adduct produced by acrolein
    Tanya Zaliznyak
    Department of Pharmacological Sciences, Stony Brook University, School of Medicine Stony Brook, NY 11794 8651, USA
    Nucleic Acids Res 37:2153-63. 2009
    b>Acrolein is a cell metabolic product and a main component of cigarette smoke. Its reaction with DNA produces two guanine lesions gamma-OH-PdG, a major adduct that is nonmutagenic in mammalian cells, and the positional isomer alpha-OH-PdG...
  85. pmc Characterization of acrolein-glycerophosphoethanolamine lipid adducts using electrospray mass spectrometry
    Karin A Zemski Berry
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Chem Res Toxicol 20:1342-51. 2007
    b>Acrolein is a toxic, highly reactive alpha,beta-unsaturated aldehyde...
  86. ncbi Respiratory tract responses in male rats following subchronic acrolein inhalation
    David C Dorman
    CIIT at The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA david
    Inhal Toxicol 20:205-16. 2008
    The goal of this study was to characterize the respiratory tract toxicity of acrolein, including nasal and pulmonary effects, in adult male F344 rats. Animals underwent whole-body exposure to 0, 0.02, 0.06, 0.2, 0.6, or 1...
  87. pmc Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family
    Irina G Minko
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Chem Res Toxicol 21:1983-90. 2008
    ..DNA under a variety of conditions, particularly following exposure to an alpha,beta-unsaturated aldehyde, acrolein. DNA-protein cross-links are subject to repair or damage-tolerance processes...
  88. ncbi Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes/macrophages through suppression of intracellular signaling
    Louis Kuoping Chao
    Department of Cosmeceutics, China Medical University, Taichung 404, Taiwan
    Food Chem Toxicol 46:220-31. 2008
    ..Our current results have demonstrated the anti-oxidation and anti-inflammatory properties of Cinnamaldehyde that could provide the possibility for Cinnamaldehyde's future pharmaceutical application in the realm of immuno-modulation...
  89. pmc Formation of deoxyguanosine cross-links from calf thymus DNA treated with acrolein and 4-hydroxy-2-nonenal
    Ivan D Kozekov
    Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235 1822, USA
    Chem Res Toxicol 23:1701-13. 2010
    b>Acrolein (AC) and 4-hydroxy-2-nonenal (HNE) are endogenous bis-electrophiles that arise from the oxidation of polyunsaturated fatty acids. AC is also found in high concentrations in cigarette smoke and automobile exhaust...
  90. ncbi In parkinsonian substantia nigra, alpha-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity
    M Shamoto-Nagai
    National Center for Geriatrics and Gerontology, Department of Geriatric Medicine, Obu, Aichi, Japan
    J Neural Transm 114:1559-67. 2007
    ..the dopamine neurons of the substantia nigra containing neuromelanin from PD patients, alphaSYN was modified with acrolein (ACR), an aldehyde product of lipid peroxidation...
  91. ncbi N(epsilon)-(3-methylpyridinium)lysine, a major antigenic adduct generated in acrolein-modified protein
    Atsunori Furuhata
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 278:48658-65. 2003
    b>Acrolein, a representative carcinogenic aldehyde, that could be ubiquitously generated in biological systems under oxidative stress shows facile reactivity with a nucleophile such as a protein...
  92. pmc Minor groove orientation of the KWKK peptide tethered via the N-terminal amine to the acrolein-derived 1,N2-gamma-hydroxypropanodeoxyguanosine lesion with a trimethylene linkage
    Hai Huang
    Department of Chemistry, Center in Molecular Toxicology, Center for Structural Biology, and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, USA
    Biochemistry 49:6155-64. 2010
    ..The structure of this DNA-KWKK conjugate is discussed in the context of its biological processing...
  93. doi Acrolein toxicity involves oxidative stress caused by glutathione depletion in the yeast Saccharomyces cerevisiae
    M Kwolek-Mirek
    Department of Biochemistry and Cell Biology, University of Rzeszow, ul Cegielniana 12, 35 959 Rzeszow, Poland
    Cell Biol Toxicol 25:363-78. 2009
    Exposure of yeast cells to allyl alcohol results in intracellular production of acrolein. The toxicity of so formed acrolein involves oxidative stress, as (1) strains deficient in antioxidant defense are hypersensitive to allyl alcohol, (..
  94. pmc Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease
    M A Bradley
    Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA
    Free Radic Biol Med 48:1570-6. 2010
    Previous studies demonstrate increased levels of 4-hydroxynonenal (HNE) and acrolein in vulnerable brain regions of subjects with mild cognitive impairment and late-stage Alzheimer disease (LAD)...
  95. pmc Acrolein-derived DNA adduct formation in human colon cancer cells: its role in apoptosis induction by docosahexaenoic acid
    Jishen Pan
    Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC 20057, USA
    Chem Res Toxicol 22:798-806. 2009
    ..Our previous studies showed that DHA, because it has a high degree of unsaturation, can give rise to the acrolein-derived 1,N(2)-propanodeoxyguanosine (Acr-dG) as a major class of DNA adducts via lipid oxidation...
  96. doi Rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates acrolein-induced airway mucus hypersecretion in rats
    Dai Shun Liu
    Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, PR China
    Toxicology 260:112-9. 2009
    ....
  97. ncbi Glucose-stimulated acrolein production from unsaturated fatty acids
    R Medina-Navarro
    Specialties Hospital, Medical Research Unit in Biochemistry, Instituto Mexicano del Seguro Social, Mexico
    Hum Exp Toxicol 23:101-5. 2004
    ..We wanted to demonstrate that acrolein can be formed directly and actively from free fatty acids in a hyperglycemic environment...
  98. ncbi Cinnamaldehyde reduction of platelet aggregation and thrombosis in rodents
    Jingqun Huang
    Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, 17 Changlexi Street, Xi an 710032, China
    Thromb Res 119:337-42. 2007
    ..Cinnamaldehyde (CA) has been reported to inhibit in vitro aggregation in human and rabbit platelets; however, little is known about the antithrombotic activities of CA in vivo...
  99. ncbi Potentiation of pulmonary reflex response to capsaicin 24h following whole-body acrolein exposure is mediated by TRPV1
    Mehdi S Hazari
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC 27599 7270, United States
    Respir Physiol Neurobiol 160:160-71. 2008
    ..While acrolein has been shown to stimulate C-fibers, the persistence of acrolein effects and the role of C-fibers in these ..
  100. ncbi Glucose autoxidation produces acrolein from lipid peroxidation in vitro
    Rafael Medina-Navarro
    Clin Chim Acta 337:183-5. 2003
  101. pmc Endothelial dysfunction and claudin 5 regulation during acrolein-induced lung injury
    An Soo Jang
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 44:483-90. 2011
    ..A major irritant in smoke, acrolein can induce ALI possibly by altering CLDN5 expression...

Research Grants87

  1. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2010
    ..scientific aims are: (1) to assess the independent role of polycyclic aromatic hydrocarbons (PAH), 1,3-butadiene, acrolein, benzene, and ethylene oxide in the development of lung cancer among smokers;(2) to assess independent role of ..
  2. ENALS IN TUMORIGENESIS
    Fung Lung Chung; Fiscal Year: 2005
    ..In addition to the cyclic propanodeoxyguanosine adducts derived from acrolein and crotonaldehyde (Acr-dG and Cro-dG, respectively)...
  3. Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth Nanoparticles
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2010
    ..ROS-induced damage will be visualized with antibodies against products of ROS activity including acrolein, nitrotyrosine and 8-hydroxy-2-deoxy-guanosine...
  4. Role of TRP Channels in Environmental Irritant-Induced Headache
    GERRY S contact OXFORD; Fiscal Year: 2010
    ..associated with indoor and outdoor air pollution but how environmental irritants, such as formaldehyde and acrolein, cause headache is not known...
  5. TRPA1 Channels in Sensory Neurons as Targets for Environmental Irritants
    Sven Eric Jordt; Fiscal Year: 2010
    ..Aldehydes such as acrolein (2-propenal) are severely irritating volatile compounds present in cigarette smoke, smoke from fires, automobile ..
  6. TRPA1 Channels in Sensory Neurons as Targets for Environmental Irritants
    Sven Eric Jordt; Fiscal Year: 2007
    ..Aldehydes such as acrolein (2-propenal) are severely irritating volatile compounds present in cigarette smoke, smoke from fires, automobile ..
  7. Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth Nanoparticles
    James McGinnis; Fiscal Year: 2009
    ..ROS-induced damage will be visualized with antibodies against products of ROS activity including acrolein, nitrotyrosine and 8-hydroxy-2-deoxy-guanosine...
  8. ENALS IN TUMORIGENESIS
    Fung Lung Chung; Fiscal Year: 2010
    ..We will focus on the cyclic deoxyguanosine adducts, the major sites of modification in DNA by enals: acrolein (Acr-dG), t-4-hydroxy-2-nonenal (HNE-dG), and malondialdehyde (MdG)...
  9. ENALS IN TUMORIGENESIS
    Fung Lung Chung; Fiscal Year: 2007
    ..We will focus on the cyclic deoxyguanosine adducts, the major sites of modification in DNA by enals: acrolein (Acr-dG), t-4-hydroxy-2-nonenal (HNE-dG), and malondialdehyde (MdG)...
  10. ENALS IN TUMORIGENESIS
    Fung Lung Chung; Fiscal Year: 2009
    ..We will focus on the cyclic deoxyguanosine adducts, the major sites of modification in DNA by enals: acrolein (Acr-dG), t-4-hydroxy-2-nonenal (HNE-dG), and malondialdehyde (MdG)...
  11. Role of Metalloproteinases in Mucin Overproduction in COPD
    GEORGE DOUGLAS LEIKAUF; Fiscal Year: 2010
    ..Importantly, irritants in cigarette smoke, particularly acrolein, can trigger these events...
  12. Sensory Neural Mechanisms of Pulmonary Agent and Vesicant Toxicity
    Sven Eric Jordt; Fiscal Year: 2007
    ..These include a,p-unsaturated aldehydes such as acrolein, a pulmonary agent used in the First World War...
  13. Lipid peroxidation product induced DNA damage in the p53 gene and liver cancer
    ERIC MOON SHONG M TANG; Fiscal Year: 2010
    ..LPO generates a variety of aldehydes, such as acrolein (Acr), crotonaldehyde, malondialdehyde (MDA), and trans-4-hydroxy- 2-nonenal (4-HNE), that are able to interact ..
  14. Lipid peroxidation product induced DNA damage in the p53 gene and liver cancer
    ERIC MOON SHONG TANG; Fiscal Year: 2006
    ..LPO generates a variety of aldehydes, such as acrolein (Acr), crotonaldehyde, malondialdehyde (MDA), and trans-4-hydroxy- 2-nonenal (4-HNE), that are able to interact ..
  15. Lipid peroxidation product induced DNA damage in the p53 gene and liver cancer
    ERIC MOON SHONG TANG; Fiscal Year: 2009
    ..LPO generates a variety of aldehydes, such as acrolein (Acr), crotonaldehyde, malondialdehyde (MDA), and trans-4-hydroxy- 2-nonenal (4-HNE), that are able to interact ..
  16. Lipid peroxidation product induced DNA damage in the p53 gene and liver cancer
    ERIC MOON SHONG TANG; Fiscal Year: 2007
    ..LPO generates a variety of aldehydes, such as acrolein (Acr), crotonaldehyde, malondialdehyde (MDA), and trans-4-hydroxy- 2-nonenal (4-HNE), that are able to interact ..
  17. TOXIC ALDEHYDES AS MODULATORS OF LUNG INFLAMMATION
    Albert van Der Vliet; Fiscal Year: 2007
    Reactive aldehydes such as acrolein (2,3-propenal) are major components of air pollution and are proposed to contribute to the adverse effects of smoking in lung diseases such as chronic obstructive pulmonary disease (COPD)...
  18. MURINE MODELS OF OCCUPATIONAL COPD
    GEORGE LEIKAUF; Fiscal Year: 2001
    ..This study seeks to use a potent aldehyde, acrolein, to induce mucus hypersecretion in a laboratory species...
  19. Shared Mechanisms of Pulmonary Lymphocyte Activation by Bacteria and Toxicants
    Michael Borchers; Fiscal Year: 2010
    ..interactions in response to the common bacteria Pseudomonas aeruginosa (PA) and the ubiquitous air pollutant, acrolein. PA is a well-characterized gram-negative bacterium that constitutes a major cause of nosocomial infections...
  20. Role of DNA In Protecting Against Secondary Leukemias
    M Dolan; Fiscal Year: 2007
    ..Initially, we will determine if acrolein creates toxic/mutagenic lesions on DNA that are repaired by MGMT...
  21. Shared Mechanisms of Pulmonary Lymphocyte Activation by Bacteria and Toxicants
    Michael Borchers; Fiscal Year: 2007
    ..interactions in response to the common bacteria Pseudomonas aeruginosa (PA) and the ubiquitous air pollutant, acrolein. PA is a well-characterized gram-negative bacterium that constitutes a major cause of nosocomial infections...
  22. Immunotoxicology of Cigarette Smoke
    Brian Freed; Fiscal Year: 2007
    ..b>Acrolein and crotonaldehyde are volatile alpha, beta-unsaturated carbonyl compounds in the gas phase of cigarette smoke; ..
  23. NEW ISOPHOSPHORAMIDE MUSTARD PRODRUGS
    David Farquhar; Fiscal Year: 2005
    ..These toxicities, which are associated with the 'unwanted metabolites' of ifosfamide, principally acrolein and chloroacetaldehyde, seriously limit optimal drug administration...