acrolein

Summary

Top Publications

  1. ncbi Mechanisms of acrolein-induced myocardial dysfunction: implications for environmental and endogenous aldehyde exposure
    Jianzhu Luo
    Institute of Molecular Cardiology, Department of Medicine, University of Louisville, 550 South Jackson Street, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 293:H3673-84. 2007
  2. ncbi TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents
    Diana M Bautista
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 124:1269-82. 2006
  3. ncbi Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
    Michael Bandell
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Neuron 41:849-57. 2004
  4. ncbi The uremic toxin acrolein promotes suicidal erythrocyte death
    Mohamed Siyabeldin E Ahmed
    Department of Physiology, University of Tuebingen, Gmelinstraße 5, 72076 Tuebingen, Germany
    Kidney Blood Press Res 37:158-67. 2013
  5. pmc Mechanisms of bactericidal action of cinnamaldehyde against Listeria monocytogenes and of eugenol against L. monocytogenes and Lactobacillus sakei
    Alexander O Gill
    Department of Food Science, Faculty of Agriculture and Food Sciences, 250 Ellis Building, 13 Freedman Crescent, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
    Appl Environ Microbiol 70:5750-5. 2004
  6. ncbi Acrolein - a pulmonary hazard
    Kiflai Bein
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Mol Nutr Food Res 55:1342-60. 2011
  7. pmc Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune encephalomyelitis mouse
    G Leung
    Department of Basic Medical Sciences, Center for Paralysis Research, Purdue University, West Lafayette, IN 47907, USA
    Neuroscience 173:150-5. 2011
  8. ncbi Attenuation of mouse somatic and emotional inflammatory pain by hydralazine through scavenging acrolein and inhibiting neuronal activation
    Lu Bai
    Department of Anatomy and K K Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, China
    Pain Physician 15:311-26. 2012
  9. ncbi The molecular effects of acrolein
    J P Kehrer
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    Toxicol Sci 57:6-15. 2000
  10. pmc Cystic fibrosis transmembrane conductance regulator modulation by the tobacco smoke toxin acrolein
    Nathan S Alexander
    Department of Surgery Division of Otolaryngology, Birmingham, Alabama, USA
    Laryngoscope 122:1193-7. 2012

Detail Information

Publications321 found, 100 shown here

  1. ncbi Mechanisms of acrolein-induced myocardial dysfunction: implications for environmental and endogenous aldehyde exposure
    Jianzhu Luo
    Institute of Molecular Cardiology, Department of Medicine, University of Louisville, 550 South Jackson Street, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 293:H3673-84. 2007
    ..Accordingly, we examined the myocardial effects of the model unsaturated aldehyde acrolein. In closed-chest mice, intravenous acrolein (0...
  2. ncbi TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents
    Diana M Bautista
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 124:1269-82. 2006
    ..TRPA1 is also targeted by environmental irritants, such as acrolein, that account for toxic and inflammatory actions of tear gas, vehicle exhaust, and metabolic byproducts of ..
  3. ncbi Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
    Michael Bandell
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Neuron 41:849-57. 2004
    ..Collectively, these data demonstrate that TRPA1 activation elicits a painful sensation and provide a potential molecular model for why noxious cold can paradoxically be perceived as burning pain...
  4. ncbi The uremic toxin acrolein promotes suicidal erythrocyte death
    Mohamed Siyabeldin E Ahmed
    Department of Physiology, University of Tuebingen, Gmelinstraße 5, 72076 Tuebingen, Germany
    Kidney Blood Press Res 37:158-67. 2013
    ..Erythrocytes could be sensitized to cytosolic Ca(2+) by ceramide. In end stage renal disease, eryptosis may possibly be stimulated by uremic toxins. The present study explored, whether the uremic toxin acrolein could trigger eryptosis.
  5. pmc Mechanisms of bactericidal action of cinnamaldehyde against Listeria monocytogenes and of eugenol against L. monocytogenes and Lactobacillus sakei
    Alexander O Gill
    Department of Food Science, Faculty of Agriculture and Food Sciences, 250 Ellis Building, 13 Freedman Crescent, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
    Appl Environ Microbiol 70:5750-5. 2004
    ..The possible mechanisms of inhibition of energy generation are inhibition of glucose uptake or utilization of glucose and effects on membrane permeability...
  6. ncbi Acrolein - a pulmonary hazard
    Kiflai Bein
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Mol Nutr Food Res 55:1342-60. 2011
    b>Acrolein is a respiratory irritant that can be generated during cooking and is in environmental tobacco smoke...
  7. pmc Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune encephalomyelitis mouse
    G Leung
    Department of Basic Medical Sciences, Center for Paralysis Research, Purdue University, West Lafayette, IN 47907, USA
    Neuroscience 173:150-5. 2011
    Oxidative stress is considered a major contributor in the pathology of multiple sclerosis (MS). Acrolein, a highly reactive aldehyde byproduct of lipid peroxidation, is thought to perpetuate oxidative stress...
  8. ncbi Attenuation of mouse somatic and emotional inflammatory pain by hydralazine through scavenging acrolein and inhibiting neuronal activation
    Lu Bai
    Department of Anatomy and K K Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, China
    Pain Physician 15:311-26. 2012
    b>Acrolein signaling is important during spinal cord injury; whether it is involved in somatic and emotional pain is not clear. Hydralazine is a potent antihypertensive drug and can scavenge acrolein efficiently.
  9. ncbi The molecular effects of acrolein
    J P Kehrer
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    Toxicol Sci 57:6-15. 2000
    b>Acrolein is a highly electrophilic alpha,beta-unsaturated aldehyde to which humans are exposed in a variety of environmental situations, particularly as a component of smoke...
  10. pmc Cystic fibrosis transmembrane conductance regulator modulation by the tobacco smoke toxin acrolein
    Nathan S Alexander
    Department of Surgery Division of Otolaryngology, Birmingham, Alabama, USA
    Laryngoscope 122:1193-7. 2012
    ..The objective of the current study was to evaluate the effects of acrolein exposure (a prominent tobacco smoke toxin) on vectorial Cl(-) transport through the major apical anion channel ..
  11. ncbi Subinhibitory concentrations of cinnamaldehyde interfere with quorum sensing
    C Niu
    Department of Biology, Georgia State University, Atlanta, GA 30303 USA
    Lett Appl Microbiol 43:489-94. 2006
    ..harveyi BB170 by nearly 60 per cent. CA did not inhibit the growth of the bioreporter strains at these concentrations. CA had a minimal effect on LasR promoter activity, induced by 3-oxo-C12-HSL...
  12. ncbi Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation
    Richard M LoPachin
    Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10467, USA
    Chem Res Toxicol 22:1499-508. 2009
    b>Acrolein and 4-hydroxy-2-nonenal (HNE) are byproducts of lipid peroxidation and are thought to play central roles in various traumatic injuries and disease states that involve cellular oxidative stress, for example, spinal cord trauma, ..
  13. pmc Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid
    Lihong Jia
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Invest Ophthalmol Vis Sci 48:339-48. 2007
    ..cigarette smoke, oxidant injury, and age-associated macular degeneration, the authors examined the effects of acrolein, a major toxicant in cigarette smoke, on oxidative mitochondrial damage in retinal pigment epithelial (RPE) cells ..
  14. pmc Acrolein-mediated injury in nervous system trauma and diseases
    Riyi Shi
    Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907 1244, USA
    Mol Nutr Food Res 55:1320-31. 2011
    b>Acrolein, an α,β-unsaturated aldehyde, is a ubiquitous pollutant that is also produced endogenously through lipid peroxidation...
  15. ncbi Acrolein induces myelin damage in mammalian spinal cord
    Yunzhou Shi
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA
    J Neurochem 117:554-64. 2011
    ..Here, we show that acrolein, a lipid peroxidation product, can cause significant myelin damage in isolated guinea pig spinal cord segments...
  16. ncbi Error prone translesion synthesis past gamma-hydroxypropano deoxyguanosine, the primary acrolein-derived adduct in mammalian cells
    Manorama Kanuri
    Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 277:18257-65. 2002
    ..deoxyguanosine, gamma-HOPdG) is a major DNA adduct that forms as a result of exposure to acrolein, an environmental pollutant and a product of endogenous lipid peroxidation...
  17. ncbi Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures
    M A Lovell
    Sanders-Brown Center on Aging and Alzheimer's Disease Research Center, 101 Sanders-Brown Building, University of Kentucky, 800 South Limestone Street, Lexington, KY 40536-0230, USA
    Neurobiol Aging 22:187-94. 2001
    ..b>Acrolein, an alpha,beta-unsaturated aldehydic product of lipid peroxidation, is approximately 100 times more reactive than ..
  18. ncbi Acrolein-induced cytotoxicity in cultured human bronchial epithelial cells. Modulation by alpha-tocopherol and ascorbic acid
    Mirella Nardini
    Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Via Ardeatina 546, 00178, Rome, Italy
    Toxicology 170:173-85. 2002
    b>Acrolein is a highly reactive unsaturated hazardous air pollutant of human health concern, particularly as a component of cigarette smoke...
  19. pmc Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp
    Gilles Brackman
    Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium
    PLoS ONE 6:e16084. 2011
    ..However, little is known about the structure-activity relationship of cinnamaldehyde analogs...
  20. pmc Proteomic profiling of acrolein adducts in human lung epithelial cells
    Page C Spiess
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    J Proteomics 74:2380-94. 2011
    b>Acrolein (2,3-propenal) is a major indoor and outdoor air pollutant originating largely from tobacco smoke or organic combustion...
  21. ncbi Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells
    Alberto Gómez-Ramos
    Centro de Biologia Molecular, CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Madrid, Spain
    J Neurosci Res 71:863-70. 2003
    ..The effect of the lipid peroxidation product acrolein on these modes of phosphorylation has been assayed...
  22. ncbi Acrolein induces inflammatory response underlying endothelial dysfunction: a risk factor for atherosclerosis
    Yong Seek Park
    Department of Microbiology and MRC for Bioreaction to ROS, Kyung Hee University School of Medicine, Seoul, Korea
    Ann N Y Acad Sci 1126:185-9. 2008
    ..Our study demonstrates that acrolein, a known toxin in tobacco smoke, elevates oxidative stress via inactivation of thioredoxin reductase and ..
  23. ncbi Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats
    T Wang
    Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China
    Eur Respir J 33:1122-32. 2009
    ..sildenafil, a potent inhibitor of PDE5 that selectively degrades cyclic guanosine 3',5'-monophosphate (cGMP), on acrolein-induced inflammation and mucus production in rat airways was examined...
  24. ncbi Potential role of acrolein in neurodegeneration and in Alzheimer's disease
    Thanh Nam Dang
    INRS Institut Armand Frappier, 531, boul des Prairies, H7V 1B7 Laval, Quebec, Canada
    Curr Mol Pharmacol 3:66-78. 2010
    Lipid peroxidation leads to the formation of a number of aldehydes by-products, including acrolein. The most abundant aldehydes are 4-hydroxy-nonenal (4-HNE) and malondialdehyde (MDA) while acrolein is the most reactive...
  25. pmc Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts
    Giorgia Volpi
    Department of Pharmacology, Chiesi Farmaceutici s p a, Parma, Italy
    Br J Pharmacol 163:649-61. 2011
    ..The aim of this study was to investigate whether acute exposure to cigarette smoke extract altered VEGF production in lung parenchymal cells...
  26. pmc CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure
    Michael T Borchers
    Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA
    Exp Mol Pathol 83:301-10. 2007
    ..In this study, we utilize a mouse model of COPD to examine the contributions of CD8(+) T cells in the persistent macrophage accumulation and airspace enlargement resulting from chronic irritant exposure...
  27. ncbi Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G2/M phase
    Ha Won Jeong
    Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosunggu, Taejeon 305 600, South Korea
    Biochem Pharmacol 65:1343-50. 2003
    ..These results support the hypothesis that the cinnamaldehyde derivative CB403 exerts cytostatic properties by inducing mitotic arrest in cancer cells...
  28. ncbi Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells
    Julie Roy
    Departement des Sciences Biologiques, TOXEN, Universite du Quebec a Montreal, Succursale Centre Ville, Canada
    Chem Biol Interact 181:154-67. 2009
    b>Acrolein is a highly reactive, alpha,beta-unsaturated aldehyde that is an omnipresent environmental pollutant. Humans are exposed to acrolein in food, vapors of overheated cooking oil, cigarette smoke and by combustion of organic products...
  29. pmc Role of endoplasmic reticulum stress in acrolein-induced endothelial activation
    Petra Haberzettl
    Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Toxicol Appl Pharmacol 234:14-24. 2009
    b>Acrolein is a ubiquitous environmental pollutant and an endogenous product of lipid peroxidation. It is also generated during the metabolism of several drugs and amino acids...
  30. pmc Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production
    Hitesh S Deshmukh
    Center for Environmental Genetics, University of Cincinnati, Cincinnati, USA
    Am J Respir Cell Mol Biol 38:446-54. 2008
    ..b>Acrolein, a constituent of cigarette smoke and an endogenous mediator of oxidative stress, increases airway mucin 5, ..
  31. ncbi Cinnamaldehyde induces endothelium-dependent and -independent vasorelaxant action on isolated rat aorta
    Ayano Yanaga
    Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama, Japan
    Biol Pharm Bull 29:2415-8. 2006
    ..Endothelium-dependent relaxation is affected by nitric oxide, and one of the mechanisms of endothelium-independent relaxation is thought to be influenced by the blocking of Ca2+ channels...
  32. ncbi Cinnamaldehyde inhibits the tumor necrosis factor-alpha-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-kappaB activation: effects upon IkappaB and Nrf2
    Being Chyuan Liao
    Department of Microbiology and Immunology, National Chiayi University, Chiayi, Taiwan
    Toxicol Appl Pharmacol 229:161-71. 2008
    ..Hence, our present findings indicate that cinnamaldehyde suppresses TNF-induced singling pathways via two distinct mechanisms that are activated by different pretreatment periods...
  33. pmc Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair
    Zhaohui Feng
    Department of Environmental Medicine, Pathology, and Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Proc Natl Acad Sci U S A 103:15404-9. 2006
    ..However, compared with other carcinogenic compounds, such as aldehydes, the amount of PAHs in CS is minute. Acrolein (Acr) is abundant in CS, and it can directly adduct DNA...
  34. pmc TRPA1 agonists evoke coughing in guinea pig and human volunteers
    Mark A Birrell
    Respiratory Pharmacology Group, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Am J Respir Crit Care Med 180:1042-7. 2009
    ..Environmental irritants such as air pollution and cigarette smoke are thought to evoke cough by stimulating airway sensory nerves; however, how this occurs is not fully understood...
  35. pmc Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke
    S Patrick Nana-Sinkam
    The Ohio State University, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, 201 Davis Heart and Lung Research Institute, 473 West 12th Avenue, Columbus, OH 43210, USA
    Am J Respir Crit Care Med 175:676-85. 2007
    ..Prostacyclin (PGI(2)) is a major product of the cyclooxygenase pathway with potent vasodilatory and antimitogenic properties and may be relevant to endothelial dysfunction in COPD...
  36. ncbi α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells
    Zhihui Feng
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Nutr Biochem 21:1222-31. 2010
    ..We investigated α-tocopherol's inducing effect on Phase II enzymes and its protective effect on acrolein-induced toxicity in a human retinal pigment epithelial (RPE) cell line, ARPE-19...
  37. ncbi Cinnamaldehyde--a potential antidiabetic agent
    P Subash Babu
    Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, Tamil Nadu, India
    Phytomedicine 14:15-22. 2007
    ..05) reduction in blood glucose concentration in STZ-induced diabetic rats. The results of this experimental study indicate that cinnamaldehyde possesses hypoglycemic and hypolipidemic effects in STZ-induced diabetic rats...
  38. ncbi Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease
    Taufika Islam Williams
    Department of Chemistry, University of Kentucky, 135 Sanders Brown Center on Aging, Lexington, KY 40506, USA
    Neurobiol Aging 27:1094-9. 2006
    ..of lipid peroxidation and neurotoxic by-products of lipid peroxidation including 4-hydroxynonenal (HNE) and acrolein in vulnerable regions of the Alzheimer's disease (AD) brain...
  39. ncbi Regulation of constitutive neutrophil apoptosis by the alpha,beta-unsaturated aldehydes acrolein and 4-hydroxynonenal
    Erik I Finkelstein
    Dept of Pathology, College of Medicine, University of Vermont, 89 Beaumont Ave Burlington, VT 05405, USA
    Am J Physiol Lung Cell Mol Physiol 289:L1019-28. 2005
    ..induce apoptotic cell death in various cell types, we recently observed that the alpha,beta-unsaturated aldehyde acrolein (ACR) can inhibit constitutive apoptosis of polymorphonuclear neutrophils and thus potentially contribute to ..
  40. pmc Protein modification by acrolein: formation and stability of cysteine adducts
    Jian Cai
    Department of Pharmacology and Toxicology, Division of Cardiology, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Chem Res Toxicol 22:708-16. 2009
    The toxicity of the ubiquitous pollutant and endogenous metabolite, acrolein, is due in part to covalent protein modifications. Acrolein reacts readily with protein nucleophiles via Michael addition and Schiff base formation...
  41. pmc Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential
    Soumya J Koppikar
    Interactive Research School for Health Affairs IRSHA, Bharati Vidyapeeth University Medical College Campus, Pune, Maharashtra, India
    BMC Cancer 10:210. 2010
    ..In the present study, we have reported the anti-neoplastic activity of cinnamon in cervical cancer cell line, SiHa...
  42. pmc Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease
    Jan F Stevens
    Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR, USA
    Mol Nutr Food Res 52:7-25. 2008
    b>Acrolein (2-propenal) is ubiquitously present in (cooked) foods and in the environment...
  43. ncbi Acrolein is a product of lipid peroxidation reaction. Formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins
    K Uchida
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    J Biol Chem 273:16058-66. 1998
    ..In the present study, we provide evidence that the formation of the toxic pollutant acrolein (CH2=CH-CHO) and its conjugate with lysine residues is involved in the oxidative modification of human low ..
  44. ncbi The FEMA GRAS assessment of cinnamyl derivatives used as flavor ingredients
    Timothy B Adams
    Flavor and Extract Manufacturers Association, 1620 I Street, N W, Suite 925, Washington, DC 20006, USA
    Food Chem Toxicol 42:157-85. 2004
    ..Scientific data relevant to the safety evaluation of the use of cinnamyl derivatives as flavoring ingredients is evaluated...
  45. pmc Acrolein induces endoplasmic reticulum stress and causes airspace enlargement
    Yoshiaki Kitaguchi
    Pulmonary and Critical Care Medicine Division, The Victoria Johnson Laboratory for Obstructive Lung Disease Research, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 7:e38038. 2012
    Given the relative abundance and toxic potential of acrolein in inhaled cigarette smoke, it is surprising how little is known about the pulmonary and systemic effects of acrolein...
  46. pmc Effect of CpG methylation at different sequence context on acrolein- and BPDE-DNA binding and mutagenesis
    Hsiang Tsui Wang
    Department of Environmental Medicine, Pathology and Medicine, New York University School of Medicine, Tuxedo Park, New York 10987, USA
    Carcinogenesis 34:220-7. 2013
    b>Acrolein (Acr), an α,β-unsaturated aldehyde, is abundant in tobacco smoke and cooking and exhaust fumes. Acr induces mutagenic α- and γ- hydroxy-1,N(2)-cyclic propano-deoxyguanosine adducts in normal human bronchial epithelial cells...
  47. ncbi Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells
    Hongqiao Zhang
    School of Natural Sciences, University of California, Merced, P O Box 2039, Merced, CA 95340, USA
    Am J Respir Cell Mol Biol 38:483-90. 2008
    ..b>Acrolein is an alpha,beta-unsaturated aldehyde present in cigarette smoke and also a product of lipid peroxidation...
  48. pmc Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility
    Hsiang Tsui Wang
    Department of Environmental Medicine, New York University School of Medicine, New York, New York 10987, USA
    J Biol Chem 287:12379-86. 2012
    b>Acrolein (Acr), a ubiquitous environmental contaminant, is a human carcinogen. Acr can react with DNA to form mutagenic α- and γ-hydroxy-1, N(2)-cyclic propano-2'-deoxyguanosine adducts (α-OH-Acr-dG and γ-OH-Acr-dG)...
  49. ncbi Induction of thioredoxin reductase as an adaptive response to acrolein in human umbilical vein endothelial cells
    Yong Seek Park
    Department of Biochemistry, Graduate School of Medicine, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 327:1058-65. 2005
    b>Acrolein is a highly electrophilic alpha,beta-unsaturated aldehyde to which humans are exposed in a variety of environment situations and is also a product of lipid peroxidation...
  50. ncbi High-performance liquid chromatography and capillary electrophoresis: methodological challenges for the determination of biologically relevant low-aliphatic aldehydes in human saliva
    Laura Annovazzi
    Dipartimento di Biochimica A Castellani, Universita di Pavia, Pavia, Italy
    Electrophoresis 25:1255-63. 2004
    ..Low-aliphatic aldehydes, such as formaldehyde, acetaldehyde and acrolein, are among the main components of mainstream cigarette smoke and their local noxious and carcinogenic effects in ..
  51. ncbi Acrolein is a mitochondrial toxin: effects on respiratory function and enzyme activities in isolated rat liver mitochondria
    Lijuan Sun
    State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, People s Republic China
    Mitochondrion 6:136-42. 2006
    b>Acrolein is an air pollutant from cigarette smoking and other pollutions and also a by-product of lipid peroxidation...
  52. ncbi Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells
    Nadia Moretto
    Dept of Pharmacology, Chiesi Farmaceutici, Parma, Italy
    Am J Physiol Lung Cell Mol Physiol 303:L929-38. 2012
    ..CSE-evoked elevation of IL-8 mRNA was mimicked by its component acrolein. Both CSE and acrolein induced p38 mitogen-activated protein kinase (MAPK) phosphorylation, accompanied by the ..
  53. ncbi Effect of acrolein and glutathione depleting agents on thioredoxin
    Xianmei Yang
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, PHAR Pharmacology, 1 University Station A1915, Austin, TX 78712 0125, USA
    Toxicology 204:209-18. 2004
    b>Acrolein is a widespread environmental pollutant that reacts rapidly with nucleophiles, especially cellular thiols...
  54. ncbi Acrolein induced DNA damage, mutagenicity and effect on DNA repair
    Moon shong Tang
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo Park, NY 10967, USA
    Mol Nutr Food Res 55:1291-300. 2011
    b>Acrolein (Acr) is a ubiquitous environmental contaminant; it also can be generated endogenously by lipid peroxidation...
  55. ncbi Acrolein induces axolemmal disruption, oxidative stress, and mitochondrial impairment in spinal cord tissue
    Jian Luo
    Department of Basic Medical Sciences, Center for Paralysis Research, Institute for Applied Neurology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA
    Neurochem Int 44:475-86. 2004
    b>Acrolein, a byproduct of oxidative stress and lipid peroxidation, has been implicated in neurodegenerative disorders such as Alzheimer's disease, but not in spinal cord trauma, as a possible key factor in neuronal degeneration...
  56. ncbi Potentiation of antifungal activity of amphotericin B by essential oil from Cinnamomum cassia
    R Giordani
    Laboratoire de Botanique, Cryptogamie et Biologie Cellulaire, Faculte de Pharmacie, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Phytother Res 20:58-61. 2006
    ..1 microL/mL of essential oil. This potentiation of amphotericin B obtained in vitro may show promise for the development of less toxic and more effective therapies especially for the treatment of HIV infection...
  57. ncbi Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway
    Chae E Kim
    Department of Pharmacology, Pusan National University, Yangsan, Gyeongnam 626 870, Korea
    Toxicol Appl Pharmacol 245:76-82. 2010
    Episodic exposure to acrolein-rich pollutants has been linked to acute myocardial infarction, and 5-lipoxygenase (5-LO) is involved in the production of matrix metalloproteinase-9 (MMP-9), which destabilizes atherosclerotic plaques...
  58. ncbi Involvement of the glutamatergic system in the nociception induced intrathecally for a TRPA1 agonist in rats
    J Z Klafke
    Programa de Pós Graduação em Ciências Biológicas Bioquímica Toxicológica, Universidade Federal de Santa Maria, 97105 900 Santa Maria, RS, Brazil
    Neuroscience 222:136-46. 2012
    ..Then the modulation of spinal TRPA1 might be a valuable target in painful conditions associated with central pain hypersensitivity...
  59. ncbi Inhibitory effects of phosphodiesterase 5 inhibitor, tadalafil, on mechanosensitive bladder afferent nerve activities of the rat, and on acrolein-induced hyperactivity of these nerves
    Tomonori Minagawa
    Department of Urology, Antwerp University Hospital and Antwerp University, Faculty of Medicine, Antwerp, Belgium
    BJU Int 110:E259-66. 2012
    ..One of the mechanisms of tadalafil on LUTS is added in the study...
  60. ncbi Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells
    R Tirumalai
    Department of Environmental Health Sciences, Division of Toxicological Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205 2179, USA
    Toxicol Lett 132:27-36. 2002
    b>Acrolein, an alpha,beta-unsaturated aldehyde, is by far the strongest electrophile present in cigarette smoke which is involved in several lung pathophysiological conditions. Acrolein depletes glutathione and creates thiol imbalance...
  61. ncbi Role of by-products of lipid oxidation in Alzheimer's disease brain: a focus on acrolein
    Manjeet Singh
    INRS Institut Armand Frappier, Laval, PQ, Canada
    J Alzheimers Dis 21:741-56. 2010
    ..formation of a number of aldehydes by-products, including malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), and acrolein. The most abundant aldehydes are HNE and MDA while acrolein is the most reactive...
  62. ncbi Acrolein health effects
    O Faroon
    ATSDR, Division of Toxicology and Environmental Medicine, Atlanta, Georgia, USA
    Toxicol Ind Health 24:447-90. 2008
    b>Acrolein is a chemical used as an intermediate reactive aldehyde in chemical industry. It is used for synthesis of many organic substances, methionine production, and methyl chloride refrigerant...
  63. ncbi Oxidative stress promotes the development of transformation: involvement of a potent mutagenic lipid peroxidation product, acrolein
    W Takabe
    Research Center for Advanced Science and Technology, The University of Tokyo, Komaba, Meguro, Tokyo 153-8904, Japan
    Carcinogenesis 22:935-41. 2001
    ..An early event during exposure to AAPH and SIN-1 was the generation of acrolein, a highly mutagenic lipid peroxidation product, which was suppressed by the addition of alpha-tocopherol...
  64. ncbi Influence of environmental parameters on production of the acrolein precursor 3-hydroxypropionaldehyde by Lactobacillus reuteri DSMZ 20016 and its accumulation by wine lactobacilli
    Rolene Bauer
    Institute for Plant Biotechnology, Genetics Department, Stellenbosch University, Matieland 7602, Stellenbosch, South Africa
    Int J Food Microbiol 137:28-31. 2010
    ..Wine quality can be gravely compromised by the accumulation of 3-HPA, due to its spontaneous conversion to acrolein under wine making conditions...
  65. ncbi A model of hemorrhagic cystitis induced with acrolein in mice
    C K L P Batista
    Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil
    Braz J Med Biol Res 39:1475-81. 2006
    b>Acrolein is a urinary metabolite of cyclophosphamide and ifosfamide, which has been reported to be the causative agent of hemorrhagic cystitis induced by these compounds...
  66. ncbi Acute acrolein-induced cystitis in mice
    Dale E Bjorling
    Department of Surgical Sciences, School of Veterinary, University of Wisconsin, Madison, WI 53706, USA
    BJU Int 99:1523-9. 2007
    To develop a method of direct intravesical administration of acrolein and evaluate the severity of cystitis in response to increasing doses of acrolein in female C57BL/6N (C57) mice, with further studies to compare the severity of acute ..
  67. ncbi Determination of acrolein and other carbonyls in cigarette smoke using coupled silica cartridges impregnated with hydroquinone and 2,4-dinitrophenylhydrazine
    Shigehisa Uchiyama
    Department of Environmental Health, National Institute of Public Health, Wako City, Saitama 351 0197, Japan
    J Chromatogr A 1217:4383-8. 2010
    A new method for the determination of acrolein and other carbonyls in cigarette smoke using a dual cartridge system has been developed. Each cartridge consists of reagent-impregnated silica particles...
  68. ncbi Suppression effect of Cinnamomum cassia bark-derived component on nitric oxide synthase
    Hoi Seon Lee
    Research Center for Industrial Development of Biofood Materials and Institute of Agricultural Science and Technology, College of Agriculture, Chonbuk National University, Chonju 561 756, South Korea
    J Agric Food Chem 50:7700-3. 2002
    ..As a naturally occurring therapeutic agent, trans-cinnamaldehyde could be useful for developing new types of NO inhibitors...
  69. pmc The effects of acrolein on the thioredoxin system: implications for redox-sensitive signaling
    Charles R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Nutr Food Res 55:1361-74. 2011
    The reactive aldehyde acrolein is a ubiquitous environmental pollutant and is also generated endogenously. It is a strong electrophile and reacts rapidly with nucleophiles including thiolates...
  70. pmc The tobacco smoke component, acrolein, suppresses innate macrophage responses by direct alkylation of c-Jun N-terminal kinase
    Milena Hristova
    Department of Pathology, College of Medicine, University of Vermont, Burlington, 05405, USA
    Am J Respir Cell Mol Biol 46:23-33. 2012
    ..innate immune system is often compromised by tobacco smoke exposure, and previous studies have indicated that acrolein, a reactive electrophile in tobacco smoke, may contribute to the immunosuppressive effects of smoking...
  71. ncbi Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention
    Eng Hui Chew
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore 117543
    Free Radic Biol Med 48:98-111. 2010
    ..These Michael acceptor molecules can potentially be exploited for use in different concentrations in chemotherapeutic and chemopreventive strategies...
  72. ncbi Simvastatin attenuates acrolein-induced mucin production in rats: involvement of the Ras/extracellular signal-regulated kinase pathway
    Ya Juan Chen
    Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
    Int Immunopharmacol 10:685-93. 2010
    ..cellular functions in the lung, we sought to investigate whether the Ras inhibitor simvastatin could attenuate acrolein-induced mucin production in rat airways...
  73. pmc Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathy
    Mohamed Ameen Ismahil
    Department of Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 301:H2050-60. 2011
    Environmental triggers of dilated cardiomyopathy are poorly understood. Acute exposure to acrolein, a ubiquitous aldehyde pollutant, impairs cardiac function and cardioprotective responses in mice...
  74. ncbi Natural polyphenols as direct trapping agents of lipid peroxidation-derived acrolein and 4-hydroxy-trans-2-nonenal
    Qin Zhu
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, PR China
    Chem Res Toxicol 22:1721-7. 2009
    b>Acrolein (ACR) and 4-hydroxy-trans-2-nonenal (HNE) are two cytotoxic lipid-derived alpha,beta-unsaturated aldehydes which have been implicated as causative agents in the development of carbonyl stress-associated pathologies...
  75. ncbi 2-hydroxycinnamaldehyde inhibits SW620 colon cancer cell growth through AP-1 inactivation
    Chung Woo Lee
    College of Pharmacy, Chungbuk National University, Korea
    J Pharmacol Sci 104:19-28. 2007
    ..These results suggested that HCA has the most potent inhibitory effect against human colon cancer cell growth, and AP-1 may be an important target of HCA...
  76. ncbi Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein
    Jeffry D Schroeter
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
    Inhal Toxicol 20:227-43. 2008
    b>Acrolein is a highly soluble and reactive aldehyde and is a potent upper-respiratory-tract irritant...
  77. ncbi Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal
    M L Iersel
    Department of Toxicology, Wageningen Agricultural University, Netherlands
    Chem Biol Interact 102:117-32. 1996
    ..The reactive acrolein did not inhibit the DNPSG-excretion at 2.5 microM, the highest non-toxic concentration...
  78. ncbi Melatonin suppresses acrolein-induced IL-8 production in human pulmonary fibroblasts
    Gun Dong Kim
    Department of Microbiology BK21, School of Medicine, Kyung Hee University, Hoegi dong, Seoul, Korea
    J Pineal Res 52:356-64. 2012
    ..Furthermore, recent studies show that, α, β-unsaturated aldehyde acrolein in CS induces the production of interleukin (IL)-8, which is known to be related to bronchitis, rhinitis, ..
  79. ncbi Genome-wide transcriptional responses to acrolein
    Colin A Thompson
    Pharmacology and Anaesthesiology Unit, School of Medicine and Pharmacology, The University of Western Australia, Perth WA 6009, Australia
    Chem Res Toxicol 21:2245-56. 2008
    The lipid peroxidation product and environmental pollutant acrolein participates in many diseases...
  80. ncbi A possible role of acrolein in diabetic retinopathy: involvement of a VEGF/TGFβ signaling pathway of the retinal pigment epithelium in hyperglycemia
    Jeffery Grigsby
    University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA
    Curr Eye Res 37:1045-53. 2012
    b>Acrolein has been implicated in retinal pigment epithelium (RPE) cell death, and has been associated with diabetic retinopathy...
  81. ncbi Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein
    Mi Kyoung Kwak
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 305:662-70. 2003
    ..by spermidine treatment, but could be inhibited by the amine oxidase inhibitor, aminoguanidine, suggesting that acrolein or hydrogen peroxide generated from polyamines by serum amine oxidase may be mediators for phase 2 enzyme ..
  82. pmc Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR
    Gilles Brackman
    Laboratory of Pharmaceutical Microbiology, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    BMC Microbiol 8:149. 2008
    ..The compounds were also evaluated in an in vivo assay measuring the reduction of Vibrio harveyi virulence towards Artemia shrimp...
  83. ncbi Effects of nitric oxide on the primary bladder afferent activities of the rat with and without intravesical acrolein treatment
    Naoki Aizawa
    Department of Urology, Faculty of Medicine, University of Antwerp, Antwerp, Belgium
    Eur Urol 59:264-71. 2011
    It has been suggested that nitric oxide (NO) affects the afferent pathways innervating the bladder. In addition, acrolein, a metabolite of cyclophosphamide, causes bladder hypersensitivity in rats.
  84. ncbi Increase in putrescine, amine oxidase, and acrolein in plasma of renal failure patients
    Kaori Sakata
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
    Biochem Biophys Res Commun 305:143-9. 2003
    ..been suggested to be one of the uremic "toxins," the levels of each polyamine, its oxidized product, acrolein, and amine oxidase in plasma of patients with renal failure were investigated...
  85. ncbi Acrolein sequestering ability of the endogenous tripeptide glycyl-histidyl-lysine (GHK): characterization of conjugation products by ESI-MSn and theoretical calculations
    Giangiacomo Beretta
    Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, University of Milan, Faculty of Pharmacy, Via Mangiagalli 25, 20133 Milan, Italy
    J Pharm Biomed Anal 47:596-602. 2008
    b>Acrolein (ACR) is a well-known carbonyl toxin produced by lipid peroxidation of polyunsaturated fatty acids, which is involved in several life-threatening pathologies such as Alzheimer disease, arteriosclerosis, diabetes, and nephropathy...
  86. pmc Acrolein inhalation prevents vascular endothelial growth factor-induced mobilization of Flk-1+/Sca-1+ cells in mice
    Laura A Wheat
    Diabetes and Obesity Center, Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40292, USA
    Arterioscler Thromb Vasc Biol 31:1598-606. 2011
    b>Acrolein is a toxic chemical present in tobacco, wood, and coal smoke, as well as automobile exhaust...
  87. ncbi Reduced 293T cell susceptibility to acrolein due to aldose reductase-like-1 protein expression
    Xuyu Zu
    Department of Medical Microbiology, Immunology, and Cell Biology, SimmonsCooper Cancer Institute, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
    Toxicol Sci 97:562-8. 2007
    b>Acrolein is a highly reactive alpha,beta-unsaturated aldehyde produced endogenously during lipid peroxidation and naturally distributed pervasively in living environments, posing serious threats to human health if not properly metabolized...
  88. ncbi Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein
    Larry G Higgins
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, UK
    Toxicol Appl Pharmacol 226:328-37. 2008
    ..Priming of nrf2(+/+) MEFs, but not nrf2(-/-) MEFs, with C+K conferred 2-fold resistance towards acrolein.
  89. ncbi Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCepsilon signaling and cardioprotection
    Guang Wu Wang
    Department of Physiology and the Cardiovascular Research Laboratories, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Mol Cell Cardiol 44:1016-22. 2008
    ..Mice were gavage-fed the alpha, beta-unsaturated aldehyde acrolein (5mg/kg) or water (vehicle) 24h prior to a 30-min coronary artery occlusion and 24-hour reperfusion...
  90. ncbi Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal
    Subbiah Pugazhenthi
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Free Radic Biol Med 40:21-34. 2006
    ..AD), oxidative stress-induced lipid peroxidation leads to accumulation of unsaturated aldehydes including acrolein and 4-hydroxynonenal (4HNE) in brain...
  91. ncbi Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction
    Nikolay Vasilyev
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Circulation 112:2812-20. 2005
    ..However, a role for MPO in formation of aldehydes in vivo and the functional consequences of MPO-generated oxidants in ischemia/reperfusion models of MI have not been established...
  92. ncbi The cigarette smoke component acrolein inhibits expression of the innate immune components IL-8 and human beta-defensin 2 by sinonasal epithelial cells
    Won Kyung Lee
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
    Am J Rhinol 21:658-63. 2007
    ..b>Acrolein (AC) is a major component of cigarette smoke that has been shown to suppress innate immune gene expression by ..
  93. pmc Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice
    Sanjay Srivastava
    Diabetes and Obesity Center, University of Louisville, Louisville, KY 40202, USA
    Atherosclerosis 215:301-8. 2011
    b>Acrolein is a dietary aldehyde that is present in high concentrations in alcoholic beverages and foods including cheese, donuts and coffee...
  94. ncbi Doxycycline attenuates acrolein-induced mucin production, in part by inhibiting MMP-9
    Shuang Ren
    Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, China
    Eur J Pharmacol 650:418-23. 2011
    ..have been found to increase the expression of epidermal growth factor (EGF) receptor, a possible regulator of acrolein-induced mucin expression in the airway epithelium...
  95. pmc Critical role of acrolein in secondary injury following ex vivo spinal cord trauma
    Kristin Hamann
    Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Neurochem 107:712-21. 2008
    ..The lipid peroxidation byproduct acrolein has been implicated as one potential mediator of secondary injury...
  96. ncbi Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells
    Hyeon Ka
    College of Pharmacy, Kyung Hee University, Hoegi dong, Dongdaemun ku, Seoul 130 701, South Korea
    Cancer Lett 196:143-52. 2003
    ..This is the first report on the mechanism of the anticancer effect of cinnamaldehyde...
  97. pmc Quantitation of acrolein-derived (3-hydroxypropyl)mercapturic acid in human urine by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: effects of cigarette smoking
    Steven G Carmella
    The Cancer Center and Transdisciplinary Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:986-90. 2007
    Recently published data suggest that acrolein (1), a toxic but weakly carcinogenic constituent of cigarette smoke, may be involved as a causative factor for the mutations frequently observed in the p53 tumor suppressor gene in lung cancer ..
  98. ncbi Effects of cinnamaldehyde on PGE2 release and TRPV4 expression in mouse cerebral microvascular endothelial cells induced by interleukin-1beta
    Yue ying Ma
    Tang Center for Herbal Medicine Research, Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China
    Biol Pharm Bull 31:426-30. 2008
    ..End3 cells. In conclusion, cinnamaldehyde decreased the production of PGE2 and the expression of TRPV4 in b.End3 cells induced by IL-1beta...
  99. ncbi Functionalized mesoporous silica nanoparticle-based drug delivery system to rescue acrolein-mediated cell death
    Youngnam Cho
    Purdue University, Center for Paralysis Research, School of Veterinary Medicine, West Lafayette, IN 47907, USA
    Nanomedicine (Lond) 3:507-19. 2008
    ..These agents restore damaged cell membranes and ameliorate abnormal mitochondria behavior induced by the endogenous toxin acrolein. Such a formulation shows potential as a novel therapeutic agent.
  100. ncbi Acrolein, IL-6 and CRP as markers of silent brain infarction
    Madoka Yoshida
    Chiba University, Inohana, Chuo Ku, Japan
    Atherosclerosis 203:557-62. 2009
    ..increased levels of polyamine oxidase (PAO) [acetylpolyamine oxidase (AcPAO) plus spermine oxidase (SMO)], and acrolein (CH(2)CHCHO) are good markers of stroke...
  101. ncbi Yap1 activation by H2O2 or thiol-reactive chemicals elicits distinct adaptive gene responses
    Xiaoguang Ouyang
    Department of Biological Sciences and W Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, TN 38152 3560, USA
    Free Radic Biol Med 50:1-13. 2011
    ..N-ethylmaleimide (NEM) showed no cross-protection against each other, whereas another thiol-reactive chemical, acrolein, elicited Yap1-dependent cross-protection against NEM, but not H(2)O(2)...

Research Grants64

  1. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..scientific aims are: (1) to assess the independent role of polycyclic aromatic hydrocarbons (PAH), 1,3-butadiene, acrolein, benzene, and ethylene oxide in the development of lung cancer among smokers;(2) to assess independent role of ..
  2. Ubiquitous pollutant acrolein inhibits IFN?? antiviral signaling: relevance to HC
    Swati Joshi-Barve; Fiscal Year: 2013
    ..b>Acrolein is a ubiquitous, highly reactive environmental and industrial pollutant, and is designated by the U.S...
  3. Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth Nanoparticles
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2010
    ..ROS-induced damage will be visualized with antibodies against products of ROS activity including acrolein, nitrotyrosine and 8-hydroxy-2-deoxy-guanosine...
  4. Molecular Mechanism of Acrolein-Induced Vascular Toxicity: Role of PPAR gamma and
    Zivar Yousefipour; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acrolein a major environmental pollutant classified by the Environmental Protection Agency (EPA) as a high-priority air/water toxic and an endogenous peroxidation product has been linked to impaired ..
  5. Lipid peroxidation product induced DNA damage in the p53 gene and liver cancer
    ERIC MOON SHONG M TANG; Fiscal Year: 2010
    ..LPO generates a variety of aldehydes, such as acrolein (Acr), crotonaldehyde, malondialdehyde (MDA), and trans-4-hydroxy- 2-nonenal (4-HNE), that are able to interact ..
  6. Cigarette Smoke-derived Electrophilic Aldehydes and Airway Inflammation
    Albert van Der Vliet; Fiscal Year: 2013
    ..on observations of protective effects of thiol-based antioxidants, the main thiol-reactive agents within CS are acrolein (2,3- propenal) and other related unsaturated aldehydes...
  7. Targeting Injury Pathways to Counteract Pulmonary Agent and Vesicant Toxicity
    Sven Eric Jordt; Fiscal Year: 2013
    ..sensory neurons, as the major neuronal target of chlorine, riot control agents and Industrial chemicals such as acrolein and isocyanates...
  8. Role of TRP Channels in Environmental Irritant-Induced Headache
    Gerry S Oxford; Fiscal Year: 2013
    ..associated with indoor and outdoor air pollution but how environmental irritants, such as formaldehyde and acrolein, cause headache is not known...
  9. Cardioprotective Mechanisms of Glutathione S-transferase P
    DANIEL JOSEPH CONKLIN; Fiscal Year: 2012
    ..of GSTP to cardiac protection during I/R in situ (Aim 1), metabolism of lipid peroxidation- derived aldehydes (acrolein and 4-hydroxy-trans-2-nonenal;HNE), which are the preferred endogenous substrates of this enzyme (Aim 2), and ..
  10. Tobacco Products and Atherosclerotic Disease
    Sanjay Srivastava; Fiscal Year: 2013
    ..atherogenesis, we will examine atherogenesis in mice exposed to individual constituents of exposure - nicotine, acrolein and crotonaldehyde, and determine how removal of these constituents affects atherosclerosis due to tobacco smoke ..
  11. NYU Lung Cancer Biomarker Center
    William N Rom; Fiscal Year: 2013
    ..We will determine risk for lung cancer among high-risk smokers by measuring blood acrolein DNA adducts and PBMC DNA repair capacity...
  12. A sensitive, ETD capable, ion trap for proteomics and PTM research
    DENNIS PETERSEN; Fiscal Year: 2012
    ..adducts due to chronic oxidative stress and the resulting lipid peroxidation products 4-hydroxynonenal and acrolein. Multiple NIH-funded researchers at the University of Colorado Denver are proposed to share the use of this ..
  13. Oxidative activation of Src in smoke-induced epithelial mesenchymal transition
    Henry Jay Forman; Fiscal Year: 2013
    ..Aim 1 is to test the hypothesis that CSE and two CSE components, hydrogen peroxide (H2O2) and acrolein, initiate Src activation through oxidation or alkylation of regulatory cysteine residues...
  14. Shared Mechanisms of Pulmonary Lymphocyte Activation by Bacteria and Toxicants
    Michael Borchers; Fiscal Year: 2010
    ..interactions in response to the common bacteria Pseudomonas aeruginosa (PA) and the ubiquitous air pollutant, acrolein. PA is a well-characterized gram-negative bacterium that constitutes a major cause of nosocomial infections...
  15. TRPA1 Channels in Sensory Neurons as Targets for Environmental Irritants
    Sven Eric Jordt; Fiscal Year: 2012
    ..Aldehydes such as acrolein (2-propenal) are severely irritating volatile compounds present in cigarette smoke, smoke from fires, automobile ..
  16. Lipid electrophile adduction of Pin1 and effects on substrate binding &activity
    Christopher D Aluise; Fiscal Year: 2013
    ..of lipid electrophiles that have been extensively studied are 4-hydroxynonenal (4-HNE), 4- oxononenal (4-ONE), acrolein, and malondialdehyde...
  17. PGP, A Possible Biomarker for COPD Exacerbations and or Progression
    J Edwin Blalock; Fiscal Year: 2013
    ..We believe this persistence is driven by endogenously produced reactive aldehydes, such as acrolein and acetaldehyde, which can acetylate PGP as well as inactivate the aminopeptidase but not hydrolase activity of ..
  18. Functional Genomics of Chemical-Induced Acute Lung Injury
    GEORGE DOUGLAS LEIKAUF; Fiscal Year: 2013
    ..In past funding period we developed and validated mouse models of acute lung injury to 5 common chemicals (acrolein, ammonia, chlorine, phosgene, and sulfuric acid)...
  19. Mechanisms of airway neurogenic inflammation by asthma-inducing allergens
    Armen N Akopian; Fiscal Year: 2013
    ..of the airways by activating the sensory neurons innervating these airways and by sensitizing the effects of acrolein and carvacrol (potent tobacco smoke and environmental irritants) on sensory neurons...
  20. The Nerve Terminal as the Site of Action for Type-2 Alkenes
    RICHARD MICHAEL LOPACHIN; Fiscal Year: 2013
    ..g., acrolein, 4-hydroxy-2-nonenal (HNE) and methyl acrylate (MA)...
  21. Role of Acrolein in Spinal Cord Injury
    Riyi Shi; Fiscal Year: 2013
    ..Evidence indicates that an aldehyde byproduct of lipid peroxidation-acrolein-is elevated following SCI, and that this species is directly toxic to neural tissues, with a much longer half-lfe ..
  22. PLASMA PROTEINS: MARKERS OF CHEMICAL EXPOSURE
    GHULAM ANSARI; Fiscal Year: 1991
    ..Industrial chemicals containing functional groups such as aldehyde (acrolein, formaldehyde, and glutaraldehyde), epoxide (ethylene oxide, propylene oxide, and styrene oxide), and hydrocarbon ..
  23. Genetic control of replication through DNA lesions in humans, and carcinogenesis
    Satya Prakash; Fiscal Year: 2013
    ..and from exposure to chemical carcinogens, 1,N2-propano-2'-deoxyguanosine (PdG), a ring-closed form of acrolein generated from lipid peroxidation and which also is a ubiquitous environmental pollutant, and N2-dG adduct of the ..
  24. Accelerating Inflammation Resolution to CounterACT Chemical Injury
    Sven Eric Jordt; Fiscal Year: 2013
    ..exposures to phosgene and acidic (HCl) or alkaline gases (ammonia) and reactive industrial chemicals such as acrolein, and to riot control agents (CS, CN or CR), and following cutaneous exposures to vesicants...
  25. Lipid-Peroxidation Induced Cyclic Adducts in Hepatocarcinogenesis
    Fung Lung Chung; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cyclic 1,N2-propanodeoxyguanosine adducts of acrolein (Acr-dG) and trans-4-hydroxy-2-nonenal (HNE-dG) derived from lipid peroxidation have been detected as endogenous DNA lesions in rodent and human ..
  26. CHEMISTRY AND BIOLOGY OF CARCINOGEN-DNA ADDUCTS
    Michael P Stone; Fiscal Year: 2010
    ..by which exposures to environmentally- and endogenously-produced bis-electrophiles, such as vinyl chloride, acrolein, crotonaldehyde, and 4- hydroxynonenal (4-HNE), induce genotoxic response, ultimately impacting human health...
  27. Laser-based spectrometer for real-time monitoring of VOCs at Superfund sites
    JOHN BRIAN LEEN; Fiscal Year: 2012
    ..g. acrolein, ozone, etc.)...
  28. ENALS IN TUMORIGENESIS
    Fung Lung Chung; Fiscal Year: 2010
    ..We will focus on the cyclic deoxyguanosine adducts, the major sites of modification in DNA by enals: acrolein (Acr-dG), t-4-hydroxy-2-nonenal (HNE-dG), and malondialdehyde (MdG)...
  29. Novel Treatments of Acrolein-induced Cardiotoxicity
    DANIEL JOSEPH CONKLIN; Fiscal Year: 2013
    Novel Treatments of Acrolein-induced Cardiotoxicity The overall goal of this project is to develop new and improved countermeasures and therapeutics for preventing human mortality and morbidity associated with chemical threats...
  30. MECHANISM OF CYCLOPHOSPHAMIDE TOXICITY
    JAMES KEHRER; Fiscal Year: 1999
    ..There is a dose- limiting toxicity to the bladder and lung that may be caused by acrolein formed via a elimination reaction following an initial 4-hydroxylation of CP...
  31. TOXIC RESPONSES OF NASAL MUCOSA TO INHALED IRRITANTS
    John Morris; Fiscal Year: 2000
    ..proposed research will characterize the immediate nasal responses in the mouse and rat to four toxic irritants: acrolein, ethyl acrylate, acetaldehyde and nitrogen dioxide...
  32. TOXIC ALDEHYDES AS MODULATORS OF LUNG INFLAMMATION
    Albert van Der Vliet; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Reactive aldehydes such as acrolein (2,3-propenal) are major components of air pollution and are proposed to contribute to the adverse effects of smoking in lung diseases such as chronic ..
  33. Immunotoxicology of Cigarette Smoke
    Brian Freed; Fiscal Year: 2007
    ..b>Acrolein and crotonaldehyde are volatile alpha, beta-unsaturated carbonyl compounds in the gas phase of cigarette smoke; ..
  34. NEW ISOPHOSPHORAMIDE MUSTARD PRODRUGS
    David Farquhar; Fiscal Year: 2005
    ..These toxicities, which are associated with the 'unwanted metabolites' of ifosfamide, principally acrolein and chloroacetaldehyde, seriously limit optimal drug administration...
  35. MESNA METABOLISM AND DISPOSITION
    MARSHALL GOREN; Fiscal Year: 2001
    ..and renal toxicity of high-dose cyclophosphamide are caused by 4- hydroxyclosphosphamide, its metabolites acrolein and phosphormide mustard, or there gluthatione conjugates, However, recent clinical an laboratory data have ..
  36. ANALYSIS OF THE AIRWAY ANTIPROTEINASE DEFENSE SYSTEM
    Sule Cataltepe; Fiscal Year: 2006
    ..be examined to determine the extent of protection against proteinase-mediated lung injury following exposure to acrolein. These studies should enhance our understanding of the mechanisms of proteinase mediated injury and whether the ..
  37. GSTs: Oxidative Stress in Early Atherosclerosis
    Paul Boor; Fiscal Year: 2006
    ..VSMCs) of rat aorta in response to electrophilic injury caused by alpha, beta-unsaturated aldehydes such as acrolein, 4-hydroxynonenal (4-HNE) and 4-hydroxyhexenal (4-HHE), which are toxic end products of lipid peroxidation ..
  38. PREVENTION OF IFOSFAMIDE INDUCED NEPHROTOXICITY
    Itzhak Nissim; Fiscal Year: 2004
    ..OH-IFO) and/or isophosphoramide mustard (IPM), secondary to depletion of [GSH] by chloroacetaldehyde (CAA) and/or acrolein (ACR)...
  39. DNA CROSSLINKING AGENTS
    Thomas Harris; Fiscal Year: 1999
    ..e., IPP), (2) three-atom tethers: malondialdehyde, acrolein, and crotonaldehyde and (3) two-atom tethers 1-chlorooxirane, chloroacetaldehyde, and glyoxal...
  40. IMMUNOASSAYS FOR MUTAGENIC AND CARCINOGENIC ADDUCTS
    CYNTHIA SEVILLA; Fiscal Year: 1990
    ..The simplest examples of such compounds are malondialdehyde, acrolein and methyl glyoxal...
  41. Activation of TRPA1 Irritant Receptors by Acrolein and Fungal Toxicants
    JASMINE ESCALERA; Fiscal Year: 2009
    ..the molecular mechanisms involved in the activation of sensory neurons by unsaturated aldehydes, particularly acrolein. -Specific Aim 1...
  42. CHARACTERIZATION OF THE LUNG PGDH
    Richard Okita; Fiscal Year: 1991
    ..The effects of acrolein, a reactive aldehyde in cigarette smoke, will be studied on PGDH activity...
  43. MECHANISM OF CYCLOPHOSPHAMIDE-INDUCED IMMUNOENHANCEMENT
    Thomas Kawabata; Fiscal Year: 1990
    ..Metabolism of Cy gives rise to the reactive phosphoramide mustard (PAM) and acrolein, which primarily bind to DNA and sulfhydryl groups, respectively...
  44. MECHANISMS OF ACROLEIN ON PROLIFERATION AND APOPTOSIS
    JAMES KEHRER; Fiscal Year: 2002
    b>Acrolein is a highly electrophilic alpha, beta-unsaturated aldehyde to which humans are exposed in a variety of environmental situations...
  45. ACROLEIN AND URINARY BLADDER CARCINOGENESIS
    Samuel Cohen; Fiscal Year: 1990
    ..b>Acrolein is present in relatively large quantities in cigarette smoke (10-140 Mug/cigarette) and is also an economically ..
  46. Clinical Development of 4-Hydroperoxyifosfamide
    LEE MORGAN; Fiscal Year: 2007
    ..An assay to monitor plasma HOO-IFOS PK and acrolein/chloroacetaldehyde levels in dogs receiving HOO- IFOS will be finalized...
  47. Clinical Development of 4-Hydroperoxyifosfamide
    LEE MORGAN; Fiscal Year: 2002
    ..levels of chloroacetaldehyde, a metabolite of IFOS implicated as the causative agent in its neurotoxicity, and acrolein, the metabolite of IFOS and CPA that causes dose-limiting hemorrhagic cystitis, generated by HOO-IFOS vs...
  48. TRANSLATIONAL STUDIES OF ALKYLATOR INDUCED LEUKEMIA
    Brian Weiss; Fiscal Year: 2005
    ..CP is metabolized to acrolein and to phosphoramide mustard (PM)...
  49. Cardiovascular Toxicity of Environmental Aldehydes
    Aruni Bhatnagar; Fiscal Year: 2007
    ..The Inhalation Facility Core (C) will provide uniform acrolein exposures to mice via inhalation...
  50. ALDEHYDE-ACTIVATED MICROPOROUS MEMBRANES
    STEPHEN WOLPERT; Fiscal Year: 1993
    ..This material, to be developed in Phase I, will be a copolymer of acrolein or methacrolein and other monomers...
  51. PARTICLE-BOUND ACROLEIN AND PULMONARY DEFENSES
    GEORGE JAKAB; Fiscal Year: 1992
    Aldehydes such as acrolein emitted by combustion sources are often associated with respirable sized particles. The majority of this hydrophilic vapor is absorbed in the upper respiratory tract...
  52. METABOLISM OF INDUSTRIAL TOXICANTS
    KENNETH LEIBMAN; Fiscal Year: 1980
    ..This includes studies of the relationship of biochemical toxicology of acrolein to its biotransformation, the mechanism of cyanide release from acrylonitrile, and the metabolism of acrylamide.
  53. MOLECULAR MECHANISMS OF HEXACARBON-INDUCED AXON ATROPHY
    RICHARD LOPACHIN; Fiscal Year: 2009
    ..Understanding the role and mechanism of axon atrophy in solvent neurotoxicity has broad-based implications for human occupational health and risk assessment. ..
  54. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
  55. NERVE REPAIR BY SYNTHETIC AND BIOLOGICAL POLYMERS
    Riyi Shi; Fiscal Year: 2003
    ..Frequent consultation with a neurosurgeon, who is a member of the research team, will provide necessary input to direct the study and experiments towards clinically relevant solutions for transection nerve injuries. ..
  56. Novel therapeutics for chronic pain
    Paul Wood; Fiscal Year: 2005
    ....
  57. GENETIC DETERMINATION OF ACUTE LUNG INJURY
    GEORGE LEIKAUF; Fiscal Year: 2004
    ..Significance: This investigation seeks to uncover novel genes not previously associated with survival during acute lung injury. Such findings could provide new biological information and insights into this severe clinical condition. ..
  58. MURINE MODELS OF OCCUPATIONAL COPD
    GEORGE LEIKAUF; Fiscal Year: 2001
    ..This study seeks to use a potent aldehyde, acrolein, to induce mucus hypersecretion in a laboratory species...
  59. Genetic Determinants of Nickel-induced Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2005
    ..Determination of the relative roles of the genetic loci linked to nickel sulfate exposure is likely to improve our understanding of the mechanisms involved in acute lung injury. ..
  60. Modifier Role of Nrf2 in Lung Injury and Emphysema
    Shyam Biswal; Fiscal Year: 2009
    ..4) To test if overexpression of Nrf2 can inhibit emphysema. These studies promise to shed new light on novel pathways that modulate susceptibility to emphysema. ..