ethylene glycols

Summary

Summary: An ethylene compound with two hydroxy groups (-OH) located on adjacent carbons. They are viscous and colorless liquids. Some are used as anesthetics or hypnotics. However, the class is best known for their use as a coolant or antifreeze.

Top Publications

  1. ncbi Occurrence of nonylphenol, nonylphenol ethoxylate surfactants and nonylphenol carboxylic acids in wastewater in Japan
    K Komori
    Water Environment Research Group, Public Works Research Institute, Tsukuba, Ibaraki, Japan
    Water Sci Technol 53:27-33. 2006
  2. doi Use of florbetapir-PET for imaging beta-amyloid pathology
    Christopher M Clark
    Avid Radiopharmaceuticals, Philadelphia, Pennsylvania, USA
    JAMA 305:275-83. 2011
  3. ncbi Folate-functionalized polymeric micelles for tumor targeted delivery of a potent multidrug-resistance modulator FG020326
    Xiaoqiang Yang
    BME Center, State Key Laboratory of Optoelectronic Materials and Technologies, School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou 510275, China
    J Biomed Mater Res A 86:48-60. 2008
  4. doi Whole-body biodistribution and brain PET imaging with [18F]AV-45, a novel amyloid imaging agent--a pilot study
    Kun Ju Lin
    Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan
    Nucl Med Biol 37:497-508. 2010
  5. pmc Crystal structure of a carbonyl reductase from Candida parapsilosis with anti-Prelog stereospecificity
    Rongzhen Zhang
    Key Laboratory of Industrial Biotechnology of Ministry of Education and School of Biotechnology, Jiangnan University, Wuxi 214122, People s Republic of China
    Protein Sci 17:1412-23. 2008
  6. pmc Optimization of automated radiosynthesis of [18F]AV-45: a new PET imaging agent for Alzheimer's disease
    Yajing Liu
    Key Laboratory of Radiopharmaceuticals, Beijing Normal University, Ministry of Education, Beijing, 100875, PR China
    Nucl Med Biol 37:917-25. 2010
  7. pmc In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18)
    Dean F Wong
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0807, USA
    J Nucl Med 51:913-20. 2010
  8. pmc Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain
    Seok Rye Choi
    Avid Radiopharmaceutical Inc, Philadelphia, Pennsylvania, USA
    J Nucl Med 50:1887-94. 2009
  9. doi The effect of a combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept) on wound healing in pigs in vivo and its in vitro percutaneous permeation through intact and barrier disrupted porcine skin
    Jessica Stahl
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany
    Int Wound J 7:62-9. 2010
  10. pmc Toxicity of ethylene glycol monomethyl ether: impact on testicular gene expression
    Gargi Bagchi
    Division of Cell and Molecular Biology, Department of Biology, Boston University, Boston, MA 02215, USA
    Int J Androl 31:269-74. 2008

Detail Information

Publications173 found, 100 shown here

  1. ncbi Occurrence of nonylphenol, nonylphenol ethoxylate surfactants and nonylphenol carboxylic acids in wastewater in Japan
    K Komori
    Water Environment Research Group, Public Works Research Institute, Tsukuba, Ibaraki, Japan
    Water Sci Technol 53:27-33. 2006
    ..removal efficiency for the short EO chain NPnEO was less significant than the long EO chain NPnEO, suggesting that the degradation rate of the short EO chain NPnEO was lower than that of the long EO chain NPnEO in the wastewater treatment..
  2. doi Use of florbetapir-PET for imaging beta-amyloid pathology
    Christopher M Clark
    Avid Radiopharmaceuticals, Philadelphia, Pennsylvania, USA
    JAMA 305:275-83. 2011
    ..The ability to identify and quantify brain β-amyloid could increase the accuracy of a clinical diagnosis of Alzheimer disease...
  3. ncbi Folate-functionalized polymeric micelles for tumor targeted delivery of a potent multidrug-resistance modulator FG020326
    Xiaoqiang Yang
    BME Center, State Key Laboratory of Optoelectronic Materials and Technologies, School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou 510275, China
    J Biomed Mater Res A 86:48-60. 2008
    ..The in vitro Rhodamine 123 efflux experiment using MDR KB(v200) cells revealed that when cells were pretreated with folate-attached and FG020326-loaded micelles, the P-glycoprotein (P-gp) drug efflux function was significantly inhibited...
  4. doi Whole-body biodistribution and brain PET imaging with [18F]AV-45, a novel amyloid imaging agent--a pilot study
    Kun Ju Lin
    Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan
    Nucl Med Biol 37:497-508. 2010
    ..This pilot study reports the safety, biodistribution, and radiation dosimetry of [(18)F]AV-45 in human subjects...
  5. pmc Crystal structure of a carbonyl reductase from Candida parapsilosis with anti-Prelog stereospecificity
    Rongzhen Zhang
    Key Laboratory of Industrial Biotechnology of Ministry of Education and School of Biotechnology, Jiangnan University, Wuxi 214122, People s Republic of China
    Protein Sci 17:1412-23. 2008
    ..This latter result provides a new example of a protein engineering approach to modify the coenzyme specificity in SCR and short-chain dehydrogenases/reductases in general...
  6. pmc Optimization of automated radiosynthesis of [18F]AV-45: a new PET imaging agent for Alzheimer's disease
    Yajing Liu
    Key Laboratory of Radiopharmaceuticals, Beijing Normal University, Ministry of Education, Beijing, 100875, PR China
    Nucl Med Biol 37:917-25. 2010
    ..We report herein an optimal [(18)F]fluorination, de-protection condition and fully automated radiosynthesis of [(18)F]AV-45 ([(18)F]5) on a radiosynthesis module (BNU F-A2)...
  7. pmc In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18)
    Dean F Wong
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0807, USA
    J Nucl Med 51:913-20. 2010
    ..Here we present the results of a clinical trial with (E)-4-(2-(6-(2-(2-(2-(18)F-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)-N-methyl benzenamine ((18)F-AV-45 or florbetapir [corrected] F 18)...
  8. pmc Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain
    Seok Rye Choi
    Avid Radiopharmaceutical Inc, Philadelphia, Pennsylvania, USA
    J Nucl Med 50:1887-94. 2009
    ..E)-4-(2-(6-(2-(2-(2-(18)F-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)-N-methyl benzenamine ((18)F-AV-45) is such as an agent currently in phase III clinical studies for PET of Abeta plaques in the brain...
  9. doi The effect of a combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept) on wound healing in pigs in vivo and its in vitro percutaneous permeation through intact and barrier disrupted porcine skin
    Jessica Stahl
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany
    Int Wound J 7:62-9. 2010
    ..Phenoxyethanol permeates through intact porcine skin in amounts of 11.3% and through barrier disrupted skin in amounts of 43.9%..
  10. pmc Toxicity of ethylene glycol monomethyl ether: impact on testicular gene expression
    Gargi Bagchi
    Division of Cell and Molecular Biology, Department of Biology, Boston University, Boston, MA 02215, USA
    Int J Androl 31:269-74. 2008
    ..Finally, given the effects of EGME on multiple genes and signalling pathways in the testis, mixture studies combining EGME, or MAA, with other testicular toxicants may help identify toxicities that are aggravated by EGME exposure...
  11. ncbi Use of 2% 2-phenoxyethanol and 0.1% octenidine as antiseptic in premature newborn infants of 23-26 weeks gestation
    C Buhrer
    Departmenmt of Neonatology, Charite Medical Center, Virchow Hospital, Berlin, Germany
    J Hosp Infect 51:305-7. 2002
    ..2-Phenoxyethanol is readily absorbed by the newborn's skin but apparently undergoes extensive oxidative metabolization to 2-phenoxyacetic acid...
  12. ncbi Exposure to ethylene glycol monomethyl ether: clinical and cytogenetic findings
    Randa A El-Zein
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Arch Environ Health 57:371-6. 2002
    ..The study characterizes EGME as a human teratogen, as indicated by the prevalence of characteristic dysmorphic features and persistent cytogenetic damage in individuals exposed in utero to this chemical...
  13. ncbi Hepatic effects of 2-butoxyethanol in rodents
    Angela M Siesky
    Division of Toxicology, Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, MS 1021, Indianapolis, Indiana 46202, USA
    Toxicol Sci 70:252-60. 2002
    ....
  14. ncbi Mechanisms of 2-butoxyethanol-induced hemangiosarcomas
    Stacy M Corthals
    Department of Pharmacology and Toxicology, Division of Toxicology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Toxicol Sci 92:378-86. 2006
    ..These events coupled together provide the events necessary for the induction of hemangiosarcomas by 2-butoxyethanol...
  15. ncbi Effects of male reproductive toxicants on gene expression in rat testes
    Tamio Fukushima
    Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Japan Inc, Aichi
    J Toxicol Sci 30:195-206. 2005
    ..These data suggest that cDNA microarray is a useful technique for evaluation of primary testicular toxicity. Furthermore, we propose the above 3 spermatogenesis-related genes as potential biomarkers of testicular toxicity...
  16. ncbi Association of liver hemangiosarcoma and secondary iron overload in B6C3F1 mice--the National Toxicology Program experience
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 9998, USA
    Toxicol Pathol 32:222-8. 2004
    ..The reason for the sex-increased susceptibility for development of hemangiosarcoma is unknown but may be due to a hormone-related, reduced antioxidative defensive capacity through modulation of the activities of antioxidative enzymes...
  17. ncbi Effects of 2-butoxyethanol on hepatic oxidative damage
    Joungjoa Park
    Division of Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, MS 1021, Indianapolis, IN 46202, USA
    Toxicol Lett 126:19-29. 2002
    ....
  18. ncbi Mode of action of butoxyethanol-induced mouse liver hemangiosarcomas and hepatocellular carcinomas
    J E Klaunig
    Indiana School of Medicine, 635 Barnhill Drive, MS 547, Indianapolis, IN 46202, USA
    Toxicol Lett 156:107-15. 2005
    ....
  19. ncbi Review of the genotoxicity of 2-butoxyethanol
    B M Elliott
    Central Toxicology Laboratory, Zeneca Ltd, Cheshire, UK
    Mutat Res 387:89-96. 1997
    ....
  20. ncbi Rat pachytene spermatocytes down-regulate a polo-like kinase and up-regulate a thiol-specific antioxidant protein, whereas sertoli cells down-regulate a phosphodiesterase and up-regulate an oxidative stress protein after exposure to methoxyethanol and met
    V Syed
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Endocrinology 139:3503-11. 1998
    ....
  21. ncbi Collaborative work on evaluation of ovarian toxicity. 11) Two- or four-week repeated-dose studies and fertility study of ethylene glycol monomethyl ether in female rats
    Tetsushi Dodo
    Drug Safety Research Laboratories Kakamigahara, Eisai Co, Ltd, Kakamigahara shi, Gifu, Japan
    J Toxicol Sci 34:SP121-8. 2009
    ..It is concluded that a repeated-dose toxicity study with a treatment period for 2 weeks or longer is sufficient for evaluation of ovarian toxicity induced by EGME...
  22. ncbi A characterization of selected endocrine disruptor compounds in a Portuguese wastewater treatment plant
    R Mauricio
    Dep de Ciências e Engenharia do Ambiente, Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Quinta da Torre 2825, Monte da Caparica, Portugal
    Environ Monit Assess 118:75-87. 2006
    ..The results are also useful since the wastewater treatment plant is located in a Mediterranean region, which results in an effluent with its own characteristics...
  23. ncbi Environmental fate of alkylphenols and alkylphenol ethoxylates--a review
    Guang Guo Ying
    CSIRO Land and Water, Adelaide Laboratory, SA, Australia
    Environ Int 28:215-26. 2002
    ..8 microg/kg NP in muscle tissue. APEs degraded faster in the water column than in sediment. Aerobic conditions facilitate easier further biotransformation of APE metabolites than anaerobic conditions...
  24. ncbi Occurrence of alkylphenolic substances in a Great Lakes coastal marsh, Cootes Paradise, ON, Canada
    T Mayer
    National Water Research Institute, Environment Canada, Burlington, ON, Canada
    Environ Pollut 147:683-90. 2007
    ..9 to 6.3 microg g(-1). To our knowledge, this is the first study to evaluate AP concentrations in tissue of benthic invertebrates under real environmental conditions...
  25. doi Simplified determination of lipophilic metabolites of nonylphenol ethoxylates: method development and application in aqueous samples from Buenos Aires, Argentina
    Paola A Babay
    Gerencia de Quimica, Centro Atomico Constituyentes, Comision Nacional de Energia Atomica, Av General Paz 1499, San Martin, Provincia de Buenos Aires B1650KNA, Argentina
    J Environ Monit 10:443-52. 2008
    ..The elevated concentrations found for the estrogenic metabolites of NPnEO are in accordance with an unrestricted use of this class of non-ionic surfactants in the country...
  26. ncbi Radiolytic decomposition of multi-class surfactants and their biotransformation products in sewage treatment plant effluents
    M Petrovic
    ICREA Catalan Institution for Research and Advance Studies, Passeig Lluis Companys 23, 08010 Barcelona, Spain
    Chemosphere 66:114-22. 2007
    ..Radiolytic treatment applied was also very effective in removing PEGs formed as by-products from APEO degradation, as well as in decomposing other surfactants, such as linear LAS, AS and AES...
  27. ncbi Steroid estrogens, nonylphenol ethoxylate metabolites, and other wastewater contaminants in groundwater affected by a residential septic system on Cape Cod, MA
    Christopher H Swartz
    Silent Spring Institute, Newton, Massachusetts 02148, USA
    Environ Sci Technol 40:4894-902. 2006
    ..The results suggest that there is the potential for migration of these OWC, which are unregulated and not routinely monitored, in groundwater...
  28. ncbi Modeling aggregate exposures to glycol ethers from use of commercial floor products
    Michael Koontz
    GEOMET Technologies, LLC, Flag Pond, Tennessee, USA
    Int J Toxicol 25:95-107. 2006
    ....
  29. ncbi Nonylphenol ethoxylates and other additives in aircraft deicers, antiicers, and waters receiving airport runoff
    Steven R Corsi
    U S Geological Survey Environmental Studies Section, Middleton, Wisconsin 53562, USA
    Environ Sci Technol 37:4031-7. 2003
    ..04 microg/L at the upstream reference, 0.98 and 7.67 microg/L at outfalls, and 3.89 microg/L in the receiving stream). The field data suggest that NP is generated through degradation of NPnEO from airport runoff...
  30. ncbi Determination of 4-nonylphenol and 4-nonylphenol ethoxylates in river sediments by microwave assisted solvent extraction
    Valeria Croce
    CNR IRSA, via Mornera 25, 1 20047 Brugherio MI, Italy
    Ann Chim 93:297-304. 2003
    ....
  31. ncbi Treatability of nonylphenol ethoxylate surfactants in on-site wastewater disposal systems
    Brent E Huntsman
    Terran Corporation, Dayton, OH 45430 1061, USA
    Water Environ Res 78:2397-404. 2006
    ..Rapid and systematic degradation of NPE in on-site wastewater disposal systems was documented...
  32. ncbi Selection and characterization of aerobic bacteria capable of degrading commercial mixtures of low-ethoxylated nonylphenols
    D Di Gioia
    DICASM, Faculty of Engineering, University of Bologna, Viale Risorgimento 2, Bologna, Italy
    J Appl Microbiol 104:231-42. 2008
    ..Isolation and characterization of new bacterial strains capable of degrading nonylphenol ethoxylates (NPnEO) with a low ethoxylation degree, which are particularly recalcitrant to biodegradation...
  33. ncbi Development and evaluation of a microemulsion formulation for transdermal delivery of terbinafine
    S Baboota
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard Hamdard University, New Delhi 1100 62, India
    PDA J Pharm Sci Technol 61:276-85. 2007
    ..05). Microbiological studies of TB in microemulsion showed better anti-fungal activity against Candida albicans and Aspergillus flavus as compared to marketed product (P < 0.05)...
  34. ncbi Electrochemical treatment of the pollutants generated in an ink-manufacturing process
    P Canizares
    Department of Chemical Engineering, Facultad de Ciencias Quimicas, Universidad de Castilla La Mancha, Campus Universitario s n, 13071 Ciudad Real, Spain
    J Hazard Mater 146:552-7. 2007
    ..These results suggest an important role of the mediated electrochemical processes on the overall performance of the reaction system...
  35. ncbi Liquid spray formulations of xibornol by using self-microemulsifying drug delivery systems
    M Cirri
    Dip Scienze Farmaceutiche, Polo Scientifico di Sesto Fiorentino, via U Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy
    Int J Pharm 340:84-91. 2007
    ....
  36. ncbi Presence of nonylphenol ethoxylate surfactants in a watershed in central Mexico and removal from domestic sewage in a treatment wetland
    Marco A Belmont
    Environmental and Resource Studies Program, Trent University, Peterborough, Ontario K9J 7B8, Canada
    Environ Toxicol Chem 25:29-35. 2006
    ..These data indicate that construction of low-cost and technologically simple treatment wetlands may be one solution to reducing the impacts of contaminants from domestic sewage in developing countries, such as Mexico...
  37. ncbi Estuarine and coastal zone marine pollution by the nonionic alkylphenol ethoxylates endocrine disrupters: is there a potential ecotoxicological problem?
    Uri Zoller
    Faculty of Science and Science Education, Chemistry, Haifa University, Oranim, Kiryat Tivon, 36006, Israel
    Environ Int 32:269-72. 2006
    ..6%, 84.7% and 76.9%, respectively, between the 8th and 28th days of exposure. Apparently, there is a potential APEOs-related ecotoxicological health risk problem...
  38. ncbi 4-nonylphenol, 4-nonylphenol mono- and diethoxylates, and other 4-alkylphenols in water and shellfish from rivers flowing into lake Biwa
    T Tsuda
    Shiga Prefectural Kusatsu Public Health Center, 13 75, Kusatsu 3, Kusatsu, Shiga 525 0034, Japan
    Bull Environ Contam Toxicol 68:126-31. 2002
  39. ncbi Analysis of organic pollutants in sewage sludges from the Valencian community (Spain)
    M F Gomez-Rico
    Chemical Engineering Department, University of Alicante, 03080, Alicante, Spain
    Arch Environ Contam Toxicol 52:306-16. 2007
    ..At the same time, it was seen that the higher values of organic pollutants belonged to digested sludges...
  40. ncbi Simultaneous sonication-assisted extraction, and determination by gas chromatography-mass spectrometry, of di-(2-ethylhexyl)phthalate, nonylphenol, nonylphenol ethoxylates and polychlorinated biphenyls in sludge from wastewater treatment plants
    I Aparicio
    Department of Analytical Chemistry, University of Seville, c Virgen de Africa 7, E 41011 Seville, Spain
    Anal Chim Acta 584:455-61. 2007
    ..4 to 10.6 microg kg(-1) for PCBs in dried sludge. The applicability of the proposed method was evaluated by the determination of these compounds in sludge from wastewater treatment plants in Seville (South Spain)...
  41. ncbi The influence of water mixtures on the dermal absorption of glycol ethers
    Matthew J Traynor
    Toxicology Unit, Institute for Research on Environment and Sustainability and Medical School, University of Newcastle upon Tyne, Newcastle NE1 7RU, UK
    Toxicol Appl Pharmacol 218:128-34. 2007
    ....
  42. ncbi Is the permeability coefficient Kp a reliable tool in percutaneous absorption studies?
    Gintautas Korinth
    Institute and Out Patient Clinic of Occupational, Social and Environmental Medicine, University Erlangen Nuremberg, Schillerstrasse 25 29, 91054, Erlangen, Germany
    Arch Toxicol 79:155-9. 2005
    ..The results of our experiments showed that the permeability coefficient Kp was not able to adjust the flux of BE to the concentration. This is in agreement with the evaluation of Kp from BE data described in the literature...
  43. ncbi Simultaneous microwave-assisted extraction of polycyclic aromatic hydrocarbons, polychlorinated biphenyls, phthalate esters and nonylphenols in sediments
    L Bartolome
    Kimika Analitikoaren Saila, Euskal Herriko Unibertsitatea, 644 Posta kutxatila, E 48080 Bilbao, Spain
    J Chromatogr A 1068:229-36. 2005
    ..This method is currently used in the study of the distribution of those organic contaminants in the estuaries of the Bay of Biscay (Spain)...
  44. ncbi Poly(ester urethane)s consisting of poly[(R)-3-hydroxybutyrate] and poly(ethylene glycol) as candidate biomaterials: characterization and mechanical property study
    Xu Li
    Institute of Materials Research and Engineering IMRE, National University of Singapore, 3 Research Link, Singapore 117602
    Biomacromolecules 6:2740-7. 2005
    ..Young's modulus and the stress at break increased with increasing PHB segment length or PEG segment length, whereas the strain at break increased with increasing PEG segment length or decreasing PHB segment length...
  45. ncbi Nonylphenol and nonylphenol ethoxylates in river water, drinking water,and fish tissues in the area of Chongqing, China
    Bing Shao
    College of Environmental Science, Peking University, Beijing, China
    Arch Environ Contam Toxicol 48:467-73. 2005
    ..1 to 2.7 microg/L) in drinking water in July. Fish samples taken in December 2000 contained 4-NP of approximately 1.9 microg/g and NPEOs of 0.4-48.3 microg/g, with the highest concentration level found in liver...
  46. ncbi Atmospheric concentrations and air-sea exchanges of nonylphenol, tertiary octylphenol and nonylphenol monoethoxylate in the North Sea
    Zhiyong Xie
    Institute for Coastal Research, GKSS Research Centre, Max Planck Street 1, D 21502 Geesthacht, Germany
    Environ Pollut 142:170-80. 2006
    ..These results suggest that the air-sea vapour exchange is an important process that intervenes in the mass balance of alkylphenols in the North Sea...
  47. ncbi Characterization of aircraft deicer and anti-icer components and toxicity in airport snowbanks and snowmelt runoff
    Steven R Corsi
    U S Geological Survey, Middleton, Wisconsin 53562, USA
    Environ Sci Technol 40:3195-202. 2006
    ..Organic markers suggest ADAF additives as a possible explanation for this increased toxicity. Results indicate that glycol cannot be used as a surrogate for fate and transport of other ADAF components...
  48. ncbi Daily intake of 4-nonylphenol in Taiwanese
    Yu Yu Lu
    Institute of Public Health, College of Medicine, National Yang Ming University, Shi Pai, Taipei, Taiwan
    Environ Int 33:903-10. 2007
    ..8+/-116.2 ng/g). This study suggested that the average daily NP intake in Taiwan is 4-fold and 8.5-fold higher than daily intake in Germany and New Zealand, respectively and rice was the major source of NP intake...
  49. ncbi Seasonal variation of hydrophobic organic contaminant concentrations in the water-column of the Seine Estuary and their transfer to a planktonic species Eurytemora affinis (Calanoïd, copepod). Part 2: Alkylphenol-polyethoxylates
    K Cailleaud
    Universite Bordeaux 1, ISM UMR 5255 CNRS, Laboratoire de Physico Toxico Chimie de l Environnement LPTC, 351 Cours de la Liberation, 33405 Talence, France
    Chemosphere 70:281-7. 2007
    ..High concentrations of NP1EO and NP were detected in all copepod samples, ranging from 3423 to 6406ngg(-1). This study is the first to report high levels of endocrine disruptors in estuarine copepods...
  50. ncbi Seasonal changes in nonylphenol ethoxylates and their metabolites in water and sediment of urban river polluted by nonylphenol
    Mamoru Motegi
    Center for Environmental Science in Saitama, 914 Kamitanadare, Kisaimachi Kitasakitamagun, Saitama 347 0115, Japan
    Environ Sci 14:109-28. 2007
    ..The surveyed results suggested that some point emission sources of nonylphenolic compounds were located in the river basin between the first sampling site and the second sampling site...
  51. ncbi Identification and quantitation of nonylphenol ethoxylates and nonylphenol in fish tissues from Michigan
    T L Keith
    Department of Zoology, National Food Safety and Toxicology Center, and Institute for Environmental Toxicology, Michigan State University, East Lansing 48824-1311, USA
    Environ Sci Technol 35:10-3. 2001
    ..NPE1 was detectable in some samples but at concentrations less than the method detection limit (16.8 ng/g). Concentrations of NPE2 and NPE3 in all samples were less than their respective MDLs of 18.2 and 20.6 ng/g...
  52. ncbi Preparation and drug loading of poly(ethylene glycol)-block-poly(epsilon-caprolactone) micelles through the evaporation of a cosolvent azeotrope
    Karen K Jette
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Pharm Res 21:1184-91. 2004
    ..The aim of this work was to study the assembly, drug loading, and stability of poly(ethylene glycol)-block-poly(epsilon-caprolactone) (PEG-b-PCL) micelles...
  53. ncbi Vertical distribution of nonylphenol and nonylphenol ethoxylates in sedimentary core from the Beipaiming Channel, North China
    Fen Jin
    State Key Lab of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    J Environ Sci (China) 19:353-7. 2007
    ..Finally, the concentrations of NP and NPEOs were related to the total organic carbon (TOC) (p < 0.001), suggesting that TOC was an important factor for vertical distribution of NPEOs and NP from the Beipaiming Channel...
  54. ncbi Globotriose- and oligo(ethylene glycol)-terminated self-assembled monolayers: surface forces, wetting, and surfactant adsorption
    Eva Blomberg
    Department of Chemistry, Surface Chemistry, Royal Institute of Technology, SE 100 44 Stockholm, Sweden
    Langmuir 22:10038-46. 2006
    ....
  55. ncbi Adsorption of aqueous alkylphenol ethoxylate surfactants by mesoporous carbon CMK-3
    Guangming Liu
    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, People s Republic of China
    J Colloid Interface Sci 302:47-53. 2006
    ..N2 adsorption results showed that the adsorption of NPE led to a decrease in the mesopore volume of CMK-3. However, the pore width of NPE-loaded CMK-3 was found to be identical to that of CMK-3...
  56. ncbi Preparation and evaluation of SEDDS and SMEDDS containing carvedilol
    Lanlan Wei
    Department of Pharmaceutics, Shen Yang Pharmaceutical University, Shen Yang, P R China
    Drug Dev Ind Pharm 31:785-94. 2005
    ..The developed SEDDS formulations significantly improved the oral bioavailability of carvedilol significantly, and the relative oral bioavailability of SEDDS compared with commercially available tablets was 413%...
  57. ncbi Effect of vehicles and enhancers on the topical delivery of cyclosporin A
    Hongzhuo Liu
    School of Pharmaceutics, Shenyang Pharmaceutical University, Wen Hua RD NO 103, Shenyang 110016, People s Republic of China
    Int J Pharm 311:182-6. 2006
    ..The present study suggests that the suspension of 40% ethanol containing 0.5% drug can more effectively enhance the topical delivery of CysA after skin pre-treatment with 10% menthol or 0.05% SLS...
  58. ncbi Determination of sex hormones and nonylphenol ethoxylates in the aqueous matrixes of two pilot-scale municipal wastewater treatment plants
    Mar Esperanza
    Department of Civil and Environmental Engineering, University of Cincinnati, Cincinnati, Ohio 45221 0071, USA
    Environ Sci Technol 38:3028-35. 2004
    ..Levels of E3 in the liquid phase were low, and no clear conclusions could be drawn concerning its removal...
  59. ncbi Treatment of diglyme containing wastewater by advanced oxidation--process design and optimisation
    D Grossmann
    , Fachbereich Ingenieurwissenschaften, , Halle/Saale, Germany
    Water Sci Technol 44:287-93. 2001
    ..The ozone/H2O2 process might offer a viable alternative in cases where the oxidation step is followed by biological wastewater treatment, so that biodegradability is aimed at...
  60. ncbi Octyl and nonylphenol ethoxylates and carboxylates in wastewater and sediments by liquid chromatography/tandem mass spectrometry
    Jorge E Loyo-Rosales
    Environmental Engineering Program, Department of Civil and Environmental Engineering, University of Maryland, College Park, MD 20742, USA
    Chemosphere 68:2118-27. 2007
    ....
  61. ncbi Combination of surfactant solubilization with permanganate oxidation for DNAPL remediation
    Zhaohui Li
    Geosciences Department, University of Wisconsin Parkside, Kenosha, WI 53144, USA
    Water Res 42:605-14. 2008
    ..The 3-D tank test showed that the MnO2 precipitation front formed more quickly when 1% SDS was present, which further confirmed the observation from the column study...
  62. ncbi Aerobic biodegradation behavior of nonylphenol polyethoxylates and their metabolites in the presence of organic matter
    Shinya Hayashi
    Graduate School of Engineering, Tohoku University, Aoba 06, Sendai 980 8579, Japan
    Environ Sci Technol 39:5626-33. 2005
    ..Organic materials such as those given above apparently play a significant role in the formation of the carboxylated metabolites of NPnEOs...
  63. ncbi Cutaneous metabolism of glycol ethers
    David J Lockley
    Skin Toxicology Group, Department of Environmental and Occupational Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    Arch Toxicol 79:160-8. 2005
    ..e. ADH1, ALDH1) and longer chain alcohols (i.e. ADH3, ADH4, ALDH1), respectively. Treatment with a general inducing agent such as dexamethasone enhanced ethanol and 2-BE metabolism suggesting induction of multiple ADH isoforms...
  64. ncbi Transdermal delivery of ketorolac tromethamine: effects of vehicles and penetration enhancers
    Young Ah Cho
    College of Pharmacy, Chosun University, Gwangju, Korea
    Drug Dev Ind Pharm 30:557-64. 2004
    ..The highest enhancing effect was attained with 10% caprylic acid in PG; the permeation flux was 113.6 +/- 17.5 microg/cm2/h. The lag time of KT was reduced as the concentration of fatty acids increased except for caprylic acid...
  65. ncbi [Evaluation of percutaneous absorption: preliminary results of a study performed in the framework of the European project EDETOX]
    F Larese
    UCO Medicina del Lavoro, Universita di Trieste, Via della Pieta 19, 34129 Trieste, Italy
    G Ital Med Lav Ergon 24:200-1. 2002
  66. ncbi Factors affecting the extent of dermal absorption of solvent vapours: a human volunteer study
    K Jones
    Health and Safety Laboratory, Broad Lane, Sheffield S3 7HQ, UK
    Ann Occup Hyg 47:145-50. 2003
    ..As for the first study, the extent of dermal absorption was determined by biological monitoring to measure the resultant body burden of the chemical...
  67. ncbi Percutaneous absorption of 5 glycol ethers through human skin in vitro
    M Venier
    Department of Chemical Sciences, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy
    Toxicol In Vitro 18:665-71. 2004
    ..57 h...
  68. ncbi Effects of experimental conditions on absorption of glycol ethers through human skin in vitro
    Simon C Wilkinson
    Skin Toxicology Unit, Department of Environmental and Occupational Medicine, The Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK
    Int Arch Occup Environ Health 75:519-27. 2002
    ..To determine effects of experimental variables on the dermal absorption of 2-ethoxyethanol (EE), 2-butoxyethanol (BE) and 1-methoxy-2-propanol (M2P) through human skin in vitro...
  69. ncbi Physiologically based pharmacokinetic modelling of human exposure to 2-butoxyethanol
    S J Franks
    Health and Safety Laboratory, Harpur Hill, Buxton S17 9JN, UK
    Toxicol Lett 162:164-73. 2006
    ....
  70. ncbi Preparation, evaluation, and NMR characterization of vinpocetine microemulsion for transdermal delivery
    L Hua
    Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, PR China
    Drug Dev Ind Pharm 30:657-66. 2004
    ..The microemulsion was stable after storing more than 12 months at 25 degrees C. The irritation study showed that the optimized microemulsion was a nonirritant transdermal delivery system...
  71. ncbi Protein adsorption on oligo(ethylene glycol)-terminated alkanethiolate self-assembled monolayers: The molecular basis for nonfouling behavior
    Lingyan Li
    Department of Chemical Engineering, University of Washington, Seattle, Washington 98105, USA
    J Phys Chem B 109:2934-41. 2005
    ..e., fibrinogen and lysozyme) adsorb more on the densely packed SAMs prepared from mixed ethanol and water solutions, while EG6OH-SAMs generally resist protein adsorption regardless of the assembly solvent used...
  72. ncbi A simple method for the determination of trace levels of alkylphenolic compounds in fish tissue using pressurized fluid extraction, solid phase cleanup, and high-performance liquid chromatography fluorescence detection
    Seema Datta
    Department of Civil and Environmental Engineering, University of Maryland, College Park, Maryland 20742, USA
    J Agric Food Chem 50:1350-4. 2002
    ..Tissue concentrations of NP and NP ethoxylates determined in fish from various locations of the Great Lakes region ranged from 18 to 2075 ng/g, wet weight...
  73. ncbi Contact angle, WAXS, and SAXS analysis of poly(beta-hydroxybutyrate) and poly(ethylene glycol) block copolymers obtained via Azotobacter vinelandii UWD
    Kerry J Townsend
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    Biotechnol Prog 21:959-64. 2005
    ..The significant decrease of the contact angle and corresponding increase in surface tension, as well as significant decrease in cell adhesion, suggest the presence of hydrophilic PEG and DEG within the hydrophobic surface...
  74. ncbi Separation of nonylphenol ethoxylates and nonylphenol by non-aqueous capillary electrophoresis
    Paola A Babay
    Unidad de Actividad Quimica, Centro Atomico Constituyentes, Comision Nacional de Energia Atomica, Av General Paz 1499, B1650KNA San Martin, Provincia de Buenos Aires, Argentina
    J Chromatogr A 1116:277-85. 2006
    ..This was demonstrated by the different peak distribution patterns observed for NPnEO compounds with n = 7.5 and 10, respectively...
  75. ncbi Alignment and assembly of adsorbed collagen molecules induced by anisotropic chemical nanopatterns
    Frédéric A Denis
    Unite de Chimie des Interfaces, Universite Catholique de Louvain, Croix du Sud 2 18, 1348 Louvain la Neuve, Belgium
    Small 1:984-91. 2005
    ..This chemical guidance effect due to self-confinement of proteins upon adsorption may bring novel and valuable applications, specifically in biomaterials science and cell growth control...
  76. ncbi All-trans-retinoic acid release from core-shell type nanoparticles of poly(epsilon-caprolactone)/poly(ethylene glycol) diblock copolymer
    Young Il Jeong
    Brain Tumor Research Laboratory, Chonnam National University Medical School, Gwangju 501 746, Korea
    Int J Pharm 273:95-107. 2004
    ..Cytotoxicity of atRA against U87MG, U251MG and U343MG cell lines were increased by nanoencapsulation while empty nanoparticles of CE diblock copolymer were not significantly affected...
  77. ncbi Reactions of oxalyl chloride with 1,2-cycloalkanediols in the presence of triethylamine
    Taisuke Itaya
    Faculty of Pharmaceutical Sciences, Kanazawa University, Japan
    Chem Pharm Bull (Tokyo) 50:83-6. 2002
    ..of triethylamine at 0 degrees C has been shown analogous to that obtained for 1,2-disubstituted acyclic ethylene glycols 1: cis-1,2-cyclooctanediol (9f) produced the cyclic oxalate 14f as the major product, while trans-1,2-..
  78. ncbi Radiolabeling and targeting of lipidic nanocapsules for applications in radioimmunotherapy
    E Jestin
    INSERM, U 601, University of Nantes, Nantes, France
    Q J Nucl Med Mol Imaging 51:51-60. 2007
    ....
  79. doi Effect of molecular weight and end-group nature on the solubility of ethylene oxide oligomers in 2H, 3H-decafluoropentane and its fully fluorinated analogue, perfluoropentane
    Marie Cote
    School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK
    J Pharm Pharmacol 60:593-9. 2008
    ..Over a wide range of temperatures and concentrations, dihydroxyl end-capped poly(ethylene glycols) (PEGs) exhibited a lower critical solution temperature (LCST) that was strongly molecular weight dependent...
  80. ncbi Dual regulation of a polyethylene glycol degradative operon by AraC-type and GalR-type regulators in Sphingopyxis macrogoltabida strain 103
    Jittima Charoenpanich
    Research Institute for Bioresources, Okayama University, 2 20 1 Chuo, Kurashiki, Okayama 710 0046, Japan
    Microbiology 152:3025-34. 2006
    ..A promoter activity assay showed that the pegB promoter was induced by PEG and oligomeric ethylene glycols, whereas the pegA and pegR promoters were induced by PEG...
  81. ncbi Synthesis of pH-sensitive amphotericin B-poly(ethylene glycol) conjugates and study of their controlled release in vitro
    Miloš Sedlák
    Department of Organic Chemistry, University of Pardubice, Cs legií 565, 532 10 Pardubice, Czech Republic
    Bioorg Med Chem 15:4069-76. 2007
    New intravenous conjugates of amphotericin B (AMB) with poly(ethylene glycols) (PEG) (M=5000, 10,000, 20,000) have been synthesized and characterised...
  82. doi Polymer molecular weight-dependent unusual fluorescence probe behavior within 1-butyl-3-methylimidazolium hexafluorophosphate+poly(ethylene glycol)
    Abhra Sarkar
    Department of Chemistry, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi 110016, India
    J Phys Chem B 113:7606-14. 2009
    Poly(ethylene glycols) (PEGs) and room-temperature ionic liquids (ILs) are both projected as possible alternatives to volatile organic compounds (VOCs)...
  83. doi A study of the interactions of ternary surfactant systems at the water-air interface
    Katarzyna Szymczyk
    Department of Interfacial Phenomena, Faculty of Chemistry, Maria Curie Sklodowska University, Maria Curie Sklodowska Sq 3, 20 031 Lublin, Poland
    Langmuir 26:2491-6. 2010
    ..ternary mixtures of cetyltrimethylammonium bromide (CTAB) and p-(1,1,3,3-tetramethylbutyl)phenoxypoly(ethylene glycols), Triton X-100 (TX100) and Triton X-165 (TX165)...
  84. ncbi Enhancement of hydrophilic drug loading and release characteristics through micellization with new carboxymethyldextran-PEG block copolymers of tunable charge density
    Ghareb Mohamed Soliman
    Faculty of Pharmacy and Department of Chemistry, Universite de Montreal, CP 6128, Succursale Centre Ville, Montreal, QC H3C 3J7, Canada
    Int J Pharm 356:248-58. 2008
    ..cationic drug, diminazene diaceturate (DIM) and a series of new diblock copolymers, carboxymethyldextran-poly(ethylene glycols) (CMD-PEG), were evaluated as a function of the ionic charge density or degree of substitution (DS) of the ..
  85. ncbi Settlement and adhesion of algal cells to hexa(ethylene glycol)-containing self-assembled monolayers with systematically changed wetting properties
    Soeren Schilp
    Angewandte Physikalische Chemie, Universitat Heidelberg, INF, Heidelberg, Germany
    Biointerphases 2:143-50. 2007
    Protein resistance of self-assembled monolayers (SAMs) of hexa(ethylene glycols) (EG(6)) has previously been shown to be dependent on the alkoxyl end-group termination of the SAM, which determines wettability [S. Herrwerth, W. Eck, S...
  86. ncbi CH2-units on (poly-)ethylene glycol radially dehydrate cytoplasm of resting skinned skeletal muscle
    Masako Kimura
    Department of Molecular Physiology, Jikei University School of Medicine, Minato ku Tokyo 105 8461, Japan
    J Biochem 143:123-9. 2008
    ..cross-section and electron micrographs of mechanically skinned fibres of frog skeletal muscle, we found that ethylene glycols (EGs) of small (mono-, di-, tri- and tetra-EGs; M(r) 62-194) and medium (poly-EGs; M(r) 900 and 3350) ..
  87. doi CH2-units on (poly-)ethylene glycol radially dehydrate cytoplasm of resting skinned skeletal muscle
    Masako Kimura
    Department of Molecular Physiology, Jikei University School of Medicine, Minato ku, Tokyo 105 8461, Japan
    J Biochem 143:841-7. 2008
    ..cross-section and electron micrographs of mechanically skinned fibres of frog skeletal muscle, we found that ethylene glycols (EGs) of small (mono-, di-, tri- and tetra-EGs; M(r) 62-194) and medium (poly-EGs; M(r) 900 and 3350) ..
  88. ncbi Cloud point of nonionic surfactants: modulation with pharmaceutical excipients
    G C Na
    Nycomed Amersham Imaging, Wayne, Pennsylvania 19087 8630, USA
    Pharm Res 16:562-8. 1999
    ..To determine the cloud point of a variety of nonionic surfactants and to search for means to raise the surfactant cloud point in liquid formulations...
  89. doi Size effect on fragmentation in tandem mass spectrometry
    Antony Memboeuf
    Institute of Structural Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri ut 59 67, 1025 Budapest, Hungary
    Anal Chem 82:2294-302. 2010
    ..energy/voltage, CCE or CCV) has been systematically determined for different types of molecules [poly(ethylene glycols) (PEG), poly(tetrahydrofuran) (PTHF), and peptides] over a wide mass (degrees of freedom) range...
  90. doi Coefficients of evaporation and gas phase diffusion of low-volatility organic solvents in nitrogen from interferometric study of evaporating droplets
    D Jakubczyk
    Institute of Physics of the Polish Academy of Sciences, 02 668 Warsaw, Poland
    J Phys Chem A 114:3483-8. 2010
    ..Mono-, di-, tri-, and tetra(ethylene glycols) and 1,3-dimethyl-2-imidazolidinone were studied. The influence of minute impurities (<0...
  91. ncbi Resolving oligomers from fully grown polymers with IMS-MS
    Sarah Trimpin
    Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA
    Anal Chem 79:7965-74. 2007
    ..techniques, combined with electrospray ionization, have been used to examine distributions of poly(ethylene glycols) (PEG) with average molecular masses of 6550 and 17900 Da...
  92. ncbi Protein adsorption to oligo(ethylene glycol) self-assembled monolayers: experiments with fibrinogen, heparinized plasma, and serum
    J Benesch
    Department of Physics and Measurement Technology, Linkopings Universitet, Linkoping, Sweden
    J Biomater Sci Polym Ed 12:581-97. 2001
    Low protein adsorption is believed advantageous for blood-contacting materials and ethylene glycols (EG)-based polymeric compounds are often attached to surfaces for this purpose...
  93. doi Ab initio modeling of defect signatures in infrared reflection-absorption spectra of SAMs exposing methyl- and hydrogen-terminated oligo(ethylene glycols)
    Lyuba Malysheva
    Bogolyubov Institute for Theoretical Physics, 03680 Kyiv, Ukraine
    J Phys Chem A 112:728-36. 2008
    ..For this family of SAMs, the presence of about 10% of all-trans conformers gives a satisfactory quantitative agreement between the calculated RA spectra and experimental observations...
  94. doi Gas-phase proton-transfer chemistry coupled with TOF mass spectrometry and ion mobility-MS for the facile analysis of poly(ethylene glycols) and PEGylated polypeptide conjugates
    Dhanashri Bagal
    Department of Molecular Structure and Analytical Sciences, Amgen, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    Anal Chem 80:2408-18. 2008
    ....
  95. ncbi Noncovalent adducts of poly(ethylene glycols) with proteins
    I N Topchieva
    Lomonosov Moscow State University, Department of Chemistry, Leninskii Gory, 119899, Moscow, Russia
    Bioconjug Chem 11:22-9. 2000
    ..The complexes between PEG chains in PEG-protein adducts and PEG-beta-CyD may be considered as a novel type of dendritic structures...
  96. ncbi Synthesis of poly(ethylene glycol)-metaxalone conjugates and study of its controlled release in vitro
    Juan Zhang
    Department of Applied Chemistry, School of Science, Northwestern Polytechnic University, Xian 710072, China
    Int J Pharm 332:125-31. 2007
    ..Met), a drug for treatment of pain and stiffness due to muscular injuries, was covalently linked to poly(ethylene glycols) (PEG) via a chloroacetyl chloride spacer...
  97. ncbi Characterisation of morphology of self-assembled PEG monolayers: a comparison of mixed and pure coatings optimised for biosensor applications
    Jochen Mehne
    Institute of Physical and Theoretical Chemistry IPTC, Eberhard Karls University of Tubingen, Auf der Morgenstelle 8, 72076, Tubingen, Germany
    Anal Bioanal Chem 391:1783-91. 2008
    ..To tailor biosensor surfaces in such a manner, poly(ethylene glycols) (PEG) in varying lengths were immobilised covalently onto glass-type surfaces in different mixing ratios and ..
  98. ncbi Biosynthesis, properties and potential of natural-synthetic hybrids of polyhydroxyalkanoates and polyethylene glycols
    L John R Foster
    Bio polymers Research Group and Centre for Advanced Macromolecular Design, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Appl Microbiol Biotechnol 75:1241-7. 2007
    Chemical conjugation with poly(ethylene glycols) (PEGs) are established procedures to facilitate solubilisation of hydrophobic compounds. Such techniques for PEGylation have been applied to polyhydroxybutyrate...
  99. ncbi Stationary-phase effects in gradient high-performance liquid chromatography
    Pavel Jandera
    Department of Analytical Chemistry, University of Pardubice, Námestic Cs legií 565, CZ 532 10 Pardubice, Czech Republic
    J Chromatogr A 1030:33-41. 2004
    ..of oligomers can be characterized by "gradient oligomer capacity", as demonstrated in the example of oligo(ethylene glycols)...
  100. ncbi Conformational studies of covalently grafted poly(ethylene glycol) on modified solid matrices using X-ray photoelectron spectroscopy
    Vinod Babu Damodaran
    Biomolecular Interaction Centre, Department of Chemical and Process Engineering, University of Canterbury, Christchurch, New Zealand 8140
    Langmuir 26:7299-306. 2010
    Amine functionalized poly(ethylene glycols) (PEGs) with molecular weights 2000 and 4000 Da were covalently grafted onto carboxy modified hydrophilic Sephadex derivatives and hydrophobic polystyrene derivatives using anhydrous amine ..
  101. doi Water soluble SERS labels comprising a SAM with dual spacers for controlled bioconjugation
    C Jehn
    Department of Physics, University of Osnabruck, Barbarastr 7, D 49069 Osnabruck, Germany
    Phys Chem Chem Phys 11:7499-504. 2009
    ..approach to synthesize hydrophilic SERS labels in which the colloidal particle is stabilized by two different ethylene glycols attached to the SAM...

Research Grants72

  1. PEGylated Prolactin Receptor Antagonists as Cancer Drugs
    MERRY SHERMAN; Fiscal Year: 2002
    ..Polymer conjugates of PRLA will be synthesized containing 1-3 strands of linear or branched poly(ethylene glycols) (PEGs) of various molecular weights (10-60 kDa), linked by various chemistries...
  2. Evolution of memory-related fMRI activation over the course of MCI and AD
    Reisa Sperling; Fiscal Year: 2008
    ..The proposed research will provide essential validation studies for fMRI as a biomarker in AD clinical trials, and enhance our fundamental understanding of the early pathophysiological alterations in AD. ..
  3. DERMAL ABSORPTION OF CHEMICALS FROM LIQUID MIXTURES
    Annette Bunge; Fiscal Year: 2006
    ..With such information in-hand, it will be possible to plan effective exposure controls and/or interventions. [unreadable] [unreadable]..
  4. Evolution of memory-related fMRI activation over the course of MCI and AD
    Reisa Sperling; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  5. Thermochemical Ablation in Image-Guided Interventions: Initial Assessment
    ERIK CRESSMAN; Fiscal Year: 2008
    ..Therefore serum osmolality, arterial blood gas measurements (pO2, pCO2, pH), and electrolytes will be monitored, with serial sampling after injection to detect changes. ..
  6. Molecular and Functional Imaging of Age Related Cognitive Decline
    William Jagust; Fiscal Year: 2009
    ....
  7. Molecular and Functional Imaging of Age Related Cognitive Decline
    William Jagust; Fiscal Year: 2008
    ....
  8. Amyloid Imaging in Frontotemporal Dementia and Alzheimer's Disease
    William Jagust; Fiscal Year: 2007
    ..PIB could become a diagnostic tool that is useful in diagnosing AD and FTLD during life. This will be especially important as new treatments for both disorders are developed. ..
  9. DERMAL ABSORPTION OF CHEMICALS FROM LIQUID MIXTURES
    Annette Bunge; Fiscal Year: 2005
    ..With such information in-hand, it will be possible to plan effective exposure controls and/or interventions. ..
  10. Evolution of memory-related fMRI activation over the course of MCI and AD
    Reisa Sperling; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  11. Evolution of memory-related fMRI activation over the course of MCI and AD
    Reisa Sperling; Fiscal Year: 2009
    ..The proposed research will provide essential validation studies for fMRI as a biomarker in AD clinical trials, and enhance our fundamental understanding of the early pathophysiological alterations in AD. ..
  12. Effects of Chemotherapy on Brain Function
    William J Jagust; Fiscal Year: 2010
    ..They are also relevant to the overall mission of the NIH because of the negative impact that cognitive dysfunction has on quality of life. ..
  13. Amyloid Imaging in Frontotemporal Dementia and Alzheimer's Disease
    William Jagust; Fiscal Year: 2008
    ..PIB could become a diagnostic tool that is useful in diagnosing AD and FTLD during life. This will be especially important as new treatments for both disorders are developed. ..
  14. Effects of Chemotherapy on Brain Function
    William Jagust; Fiscal Year: 2009
    ..They are also relevant to the overall mission of the NIH because of the negative impact that cognitive dysfunction has on quality of life. ..
  15. DERMAL ABSORPTION OF CHEMICALS FROM LIQUID MIXTURES
    Annette Bunge; Fiscal Year: 2004
    ..With such information in-hand, it will be possible to plan effective exposure controls and/or interventions. ..
  16. Molecular and Functional Imaging of Age Related Cognitive Decline
    William Jagust; Fiscal Year: 2007
    ....
  17. Amyloid Imaging in Frontotemporal Dementia and Alzheimer's Disease
    William Jagust; Fiscal Year: 2009
    ..PIB could become a diagnostic tool that is useful in diagnosing AD and FTLD during life. This will be especially important as new treatments for both disorders are developed. ..
  18. Evaluation of a Novel Amyloid Plaque SPECT Tracer for Diagnosing AD
    Andrew B Newberg; Fiscal Year: 2010
    ....
  19. Evolution of memory-related fMRI activation over the course of MCI and AD
    Reisa A Sperling; Fiscal Year: 2010
    ..The proposed research will provide essential validation studies for fMRI as a biomarker in AD clinical trials, and enhance our fundamental understanding of the early pathophysiological alterations in AD. ..
  20. POSTMENOPAUSAL ESTROGEN INFLUENCES ON OLFACTION
    RICHARD DOTY; Fiscal Year: 2000
    ..Third, it would lead to testable hypotheses regarding the role of reproductive hormones, and their underlying mechanisms, in the maintenance of normal olfactory function. ..
  21. Training for Clinician Scientists in Imaging Research
    DEAN WONG; Fiscal Year: 2007
    ..The long term goal is to attract resident physicians into a career employing imaging research as a major component of their future academic careers. ..
  22. Mechanisms of Dopamine and Serotonin in Tourette Syndrome
    DEAN WONG; Fiscal Year: 2007
    ..At the end of this renewal, we will have completed our originally funded AIMS and examined new possibilities of 5HT and DA interrelationships and role of co morbid OCD and TS. ..
  23. 3D IMAGING & COMPUTER MODEL OF THE RESPIRATORY TRACT
    Richard Corley; Fiscal Year: 2007
    ..A fourth core will serve as an administrative interface and will provide statistical support among the participating institutions and projects. ..
  24. Human Imaging Research in Neuropsychiatry and Drug Abuse
    DEAN WONG; Fiscal Year: 2007
    ..It is my strong belief that this progress will be maintained, even accelerated, in my additional five years. ..
  25. Molecular Biomarkers as Predictors of Hodgkin's Disease
    Randa El Zein; Fiscal Year: 2007
    ..The high risk population can be targeted for intensive preventive and early detection strategies. ..
  26. IMAGING DOPAMINE RELEASE/ENDOCRINE CHANGES IN ALCOHOLISM
    DEAN WONG; Fiscal Year: 2000
    ..If the initial D2 receptor deficits are exacerbated by alcohol abuse one can envision a positive feedback loop hard to break. ..
  27. High End Computing for PET/SPECT
    DEAN WONG; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  28. Semiconductor Nanocrystals for Biomedical Imaging
    Fei Wang; Fiscal Year: 2005
    ..Both types of encapsulated nanoparticle probes will be used to transfect cultured mammalian cells in order to assess QD luminescence in a physiological milieu. ..
  29. MECHANISMS OF DOPAMINE & SEROTONIN IN TOURETTE SYNDROME
    DEAN WONG; Fiscal Year: 2001
    ..We propose to carry out experiments using PET to establish a more complete understanding of the neurotransmission in TS. This will also help establish new ationales for improved therapeutics in TS. ..
  30. OLFACTION IN MULTIPLE SCLEROSIS
    RICHARD DOTY; Fiscal Year: 2000
    ....
  31. OLFACTION IN EPILEPSY
    RICHARD DOTY; Fiscal Year: 2000
    ..In addition to providing a better understanding of the influences of TLE and TLR on human olfactory function, this work may lead to the development of a simple and inexpensive non-invasive means for better establishing TLE seizure loci. ..
  32. Mechanisms of Dopamine and Serotonin in Tourette Syndrome
    DEAN FOSTER WONG; Fiscal Year: 2010
    ..At the end of this renewal, we will have completed our originally funded AIMS and examined new possibilities of 5HT and DA interrelationships and role of co morbid OCD and TS. ..
  33. Mechanisms of Dopamine and Serotonin in Tourette Syndrome
    DEAN WONG; Fiscal Year: 2008
    ..At the end of this renewal, we will have completed our originally funded AIMS and examined new possibilities of 5HT and DA interrelationships and role of co morbid OCD and TS. ..
  34. OLFACTION IN MULTIPLE SCLEROSIS
    RICHARD DOTY; Fiscal Year: 1999
    ....
  35. IMAGING DOPAMINE RELEASE/ENDOCRINE CHANGES IN ALCOHOLISM
    DEAN WONG; Fiscal Year: 2001
    ..If the initial D2 receptor deficits are exacerbated by alcohol abuse one can envision a positive feedback loop hard to break. ..
  36. Functionalized Star Polymer Nanoparticles for Controlled Drug Delivery
    Fei Wang; Fiscal Year: 2008
    ..The polymer/drug medication will minimize early degradation of the encapsulated drug and decrease harmful side-effects from premature drug release. [unreadable] [unreadable] [unreadable] [unreadable]..
  37. Cytokinesis-blocked micronucleus assay: a predictive biomarker of lung cancer ris
    Randa El Zein; Fiscal Year: 2008
    ..This approach will in turn allow the development of this assay into a cancer risk assessment tool for identification of high-risk individuals. ..
  38. Human Imaging Research in Neuropsychiatry and Drug Abuse
    DEAN WONG; Fiscal Year: 2008
    ..It is my strong belief that this progress will be maintained, even accelerated, in my additional five years. ..
  39. 3D IMAGING & COMPUTER MODEL OF THE RESPIRATORY TRACT
    Richard Corley; Fiscal Year: 2008
    ..A fourth core will serve as an administrative interface and will provide statistical support among the participating institutions and projects. ..
  40. 3D IMAGING & COMPUTER MODEL OF THE RESPIRATORY TRACT
    Richard A Corley; Fiscal Year: 2010
    ....
  41. Mechanisms of Dopamine and Serotonin in Tourette Syndrome
    DEAN WONG; Fiscal Year: 2006
    ..At the end of this renewal, we will have completed our originally funded AIMS and examined new possibilities of 5HT and DA interrelationships and role of co morbid OCD and TS. ..
  42. OLFACTION IN MULTIPLE SCLEROSIS
    RICHARD DOTY; Fiscal Year: 2001
    ....
  43. Dedicated High Performance Human Brain/Preclinical PET
    DEAN WONG; Fiscal Year: 2004
    ..abstract_text> ..
  44. OLFACTION IN EPILEPSY
    RICHARD DOTY; Fiscal Year: 2002
    ..In addition to providing a better understanding of the influences of TLE and TLR on human olfactory function, this work may lead to the development of a simple and inexpensive non-invasive means for better establishing TLE seizure loci. ..
  45. OLFACTION IN EPILEPSY
    RICHARD DOTY; Fiscal Year: 2004
    ..In addition to providing a better understanding of the influences of TLE and TLR on human olfactory function, this work may lead to the development of a simple and inexpensive non-invasive means for better establishing TLE seizure loci. ..
  46. Molecular Biomarkers as Predictors of Hodgkin's Disease
    Randa El Zein; Fiscal Year: 2003
    ..The high risk population can be targeted for intensive preventive and early detection strategies. ..
  47. IMAGING DOPAMINE RELEASE/ENDOCRINE CHANGES IN ALCOHOLISM
    DEAN WONG; Fiscal Year: 2003
    ..If the initial D2 receptor deficits are exacerbated by alcohol abuse one can envision a positive feedback loop hard to break. ..
  48. MECHANISMS OF DOPAMINE & SEROTONIN IN TOURETTE SYNDROME
    DEAN WONG; Fiscal Year: 2003
    ..We propose to carry out experiments using PET to establish a more complete understanding of the neurotransmission in TS. This will also help establish new ationales for improved therapeutics in TS. ..
  49. GLUCOCORTICOID RECEPTOR-MEDIATED CATARACT
    Eric James; Fiscal Year: 2003
    ....
  50. OLFACTION IN EPILEPSY
    RICHARD DOTY; Fiscal Year: 2003
    ..In addition to providing a better understanding of the influences of TLE and TLR on human olfactory function, this work may lead to the development of a simple and inexpensive non-invasive means for better establishing TLE seizure loci. ..
  51. POSTMENOPAUSAL ESTROGEN INFLUENCES ON OLFACTION
    RICHARD DOTY; Fiscal Year: 2003
    ..Third, it would lead to testable hypotheses regarding the role of reproductive hormones, and their underlying mechanisms, in the maintenance of normal olfactory function. ..
  52. MECHANISMS OF DOPAMINE & SEROTONIN IN TOURETTE SYNDROME
    DEAN WONG; Fiscal Year: 2002
    ..We propose to carry out experiments using PET to establish a more complete understanding of the neurotransmission in TS. This will also help establish new ationales for improved therapeutics in TS. ..
  53. IMAGING DOPAMINE RELEASE/ENDOCRINE CHANGES IN ALCOHOLISM
    DEAN WONG; Fiscal Year: 2002
    ..If the initial D2 receptor deficits are exacerbated by alcohol abuse one can envision a positive feedback loop hard to break. ..
  54. Molecular Biomarkers as Predictors of Hodgkin's Disease
    Randa El Zein; Fiscal Year: 2004
    ..The high risk population can be targeted for intensive preventive and early detection strategies. ..
  55. POSTMENOPAUSAL ESTROGEN INFLUENCES ON OLFACTION
    RICHARD DOTY; Fiscal Year: 2004
    ..Third, it would lead to testable hypotheses regarding the role of reproductive hormones, and their underlying mechanisms, in the maintenance of normal olfactory function. ..
  56. POSTMENOPAUSAL ESTROGEN INFLUENCES ON OLFACTION
    RICHARD DOTY; Fiscal Year: 2005
    ..Third, it would lead to testable hypotheses regarding the role of reproductive hormones, and their underlying mechanisms, in the maintenance of normal olfactory function. ..
  57. 3D IMAGING & COMPUTER MODEL OF THE RESPIRATORY TRACT
    Richard Corley; Fiscal Year: 2006
    ..A fourth core will serve as an administrative interface and will provide statistical support among the participating institutions and projects. ..
  58. Molecular Biomarkers as Predictors of Hodgkin's Disease
    Randa El Zein; Fiscal Year: 2006
    ..The high risk population can be targeted for intensive preventive and early detection strategies. ..
  59. OLFACTION IN EPILEPSY
    RICHARD DOTY; Fiscal Year: 2001
    ..In addition to providing a better understanding of the influences of TLE and TLR on human olfactory function, this work may lead to the development of a simple and inexpensive non-invasive means for better establishing TLE seizure loci. ..
  60. BRANCHED COPOLYMER AS PEPTIDE DRUG DELIVERY SYSTEM
    Fei Wang; Fiscal Year: 2006
    ..New drug delivery systems have had an impact on nearly every branch of medicine. Controlled drug delivery is a $20 billion industry and rising rapidly...
  61. POSTMENOPAUSAL ESTROGEN INFLUENCES ON OLFACTION
    RICHARD DOTY; Fiscal Year: 2001
    ..Third, it would lead to testable hypotheses regarding the role of reproductive hormones, and their underlying mechanisms, in the maintenance of normal olfactory function. ..
  62. IMAGING DOPAMINE/SEROTONIN MECHANISMS IN COCAINE CRAVING
    DEAN WONG; Fiscal Year: 2003
    ..Testing of these hypotheses will provide novel and fundamental answers to craving mechanisms. ..
  63. 3D IMAGING & COMPUTER MODEL OF THE RESPIRATORY TRACT
    Richard Corley; Fiscal Year: 2005
    ..A fourth core will serve as an administrative interface and will provide statistical support among the participating institutions and projects. ..
  64. Molecular Biomarkers as Predictors of Hodgkin's Disease
    Randa El Zein; Fiscal Year: 2005
    ..The high risk population can be targeted for intensive preventive and early detection strategies. ..
  65. STAR POLYMER UNIMOLECULAR MICELLES FOR DRUG DELIVERY
    Fei Wang; Fiscal Year: 2004
    ..abstract_text> ..
  66. IMAGING DOPAMINE RELEASE/ENDOCRINE CHANGES IN ALCOHOLISM
    DEAN WONG; Fiscal Year: 2004
    ..If the initial D2 receptor deficits are exacerbated by alcohol abuse one can envision a positive feedback loop hard to break. ..
  67. 3D IMAGING & COMPUTER MODEL OF THE RESPIRATORY TRACT
    Richard Corley; Fiscal Year: 2004
    ..A fourth core will serve as an administrative interface and will provide statistical support among the participating institutions and projects. ..
  68. POSTMENOPAUSAL ESTROGEN INFLUENCES ON OLFACTION
    RICHARD DOTY; Fiscal Year: 2002
    ..Third, it would lead to testable hypotheses regarding the role of reproductive hormones, and their underlying mechanisms, in the maintenance of normal olfactory function. ..