glycols

Summary

Summary: A generic grouping for dihydric alcohols with the hydroxy groups (-OH) located on different carbon atoms. They are viscous liquids with high boiling points for their molecular weights.

Top Publications

  1. ncbi Simplified assay of diethylene glycol and ethylene glycol in various raw materials by capillary gas chromatography
    K Molever
    Research and Development Department, The Dial Corporation, a Henkel Company, Scottsdale, AZ 85255, USA
    J Cosmet Sci 61:225-34. 2010
  2. ncbi Hydrotropic oligomer-conjugated glycol chitosan as a carrier of paclitaxel: synthesis, characterization, and in vivo biodistribution
    G Saravanakumar
    Department of Advanced Polymer and Fiber Materials, Kyung Hee University, Gyeonggi Do 446 701, Republic of Korea
    J Control Release 140:210-7. 2009
  3. ncbi An overview on 2-methyl-2,4-pentanediol in crystallization and in crystals of biological macromolecules
    Kanchan Anand
    Department of Structural Biology and Crystrallography, Institute of Molecular Biotechnology, Beutenbergstr 11, D-07745 Jena, Germany
    Acta Crystallogr D Biol Crystallogr 58:1722-8. 2002
  4. ncbi Male-produced aggregation pheromone of the cerambycid beetle Neoclytus acuminatus acuminatus
    Emerson S Lacey
    Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    J Chem Ecol 30:1493-507. 2004
  5. ncbi Crystallization, structure solution and refinement of hen egg-white lysozyme at pH 8.0 in the presence of MPD
    M S Weiss
    Institute of Molecular Biotechnology, Department of Structural Biology and Crystallography, PO Box 100813, D 07708 Jena, Germany
    Acta Crystallogr D Biol Crystallogr 56:952-8. 2000
  6. ncbi Refolding SDS-denatured proteins by the addition of amphipathic cosolvents
    Catherine Michaux
    Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, 101 College Street, Toronto, Ontario, Canada
    J Mol Biol 375:1477-88. 2008
  7. ncbi Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia
    Magnus Bäck
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:17501-6. 2005
  8. ncbi Homologous desensitisation of the mouse leukotriene B4 receptor involves protein kinase C-mediated phosphorylation of serine 127
    Jens Mollerup
    Department of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
    Cell Physiol Biochem 20:143-56. 2007
  9. ncbi Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival
    Jana Stankova
    Immunology Division, Department of Pediatrics, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Immunol 168:3570-6. 2002
  10. ncbi Blockade of leukotriene B4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer
    Aya Ihara
    Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Pharmacol Sci 103:24-32. 2007

Research Grants

  1. TRANSCRIPTION COUPLED REPAIR IN EUKARYOTIC CELLS
    STEVEN LEADON; Fiscal Year: 1999
  2. MOLECULAR BARRIERS TO THROMBOSIS ON TISSUE SURFACES
    William Wagner; Fiscal Year: 2002
  3. Overexpression and crystallization of amino acid transp*
    Da Neng Wang; Fiscal Year: 2002
  4. PEGylated Prolactin Receptor Antagonists as Cancer Drugs
    MERRY SHERMAN; Fiscal Year: 2002
  5. Processing of Radiation Damage by Translesion DNA Synthesis
    Susan Wallace; Fiscal Year: 2007
  6. Processing of Radiation Damage by Translesion DNA Synthesis
    SYLVIE DOUBLIE; Fiscal Year: 2010
  7. ROS-induced Nucleic Acid Damage
    Yinsheng Wang; Fiscal Year: 2006
  8. Oxidative Crosslink Lesions and CpG Mutagenesis
    Yinsheng Wang; Fiscal Year: 2007
  9. Chemistry and Biology of DNA Carboxyalkylation
    Yinsheng Wang; Fiscal Year: 2010
  10. Chemistry and Biology of DNA Carboxyalkylation
    Yinsheng Wang; Fiscal Year: 2010

Detail Information

Publications184 found, 100 shown here

  1. ncbi Simplified assay of diethylene glycol and ethylene glycol in various raw materials by capillary gas chromatography
    K Molever
    Research and Development Department, The Dial Corporation, a Henkel Company, Scottsdale, AZ 85255, USA
    J Cosmet Sci 61:225-34. 2010
    ..In addition, NF monographs for polyethylene glycols (PEG) and polyethylene glycol monomethyl ethers (MPEG) used in pharmaceutical products also require DEG and EG ..
  2. ncbi Hydrotropic oligomer-conjugated glycol chitosan as a carrier of paclitaxel: synthesis, characterization, and in vivo biodistribution
    G Saravanakumar
    Department of Advanced Polymer and Fiber Materials, Kyung Hee University, Gyeonggi Do 446 701, Republic of Korea
    J Control Release 140:210-7. 2009
    ..5)-labeled HO-GC-PTX showed an excellent tumor specificity in SCC7 tumor-bearing mice, due to the enhanced permeation and retention effect. Overall, HO-GC-PTX nanoparticles might be a promising carrier for PTX delivery in cancer therapy...
  3. ncbi An overview on 2-methyl-2,4-pentanediol in crystallization and in crystals of biological macromolecules
    Kanchan Anand
    Department of Structural Biology and Crystrallography, Institute of Molecular Biotechnology, Beutenbergstr 11, D-07745 Jena, Germany
    Acta Crystallogr D Biol Crystallogr 58:1722-8. 2002
    ..Our analysis suggests that MPD is not as strong a denaturant as often suggested. It promotes stabilization of the protein by preferential hydration, which is facilitated by attachment of MPD molecules to the hydrophobic surface...
  4. ncbi Male-produced aggregation pheromone of the cerambycid beetle Neoclytus acuminatus acuminatus
    Emerson S Lacey
    Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    J Chem Ecol 30:1493-507. 2004
    ..It is likely that males of other species in this large subfamily produce pheromones that are variations on this structural motif...
  5. ncbi Crystallization, structure solution and refinement of hen egg-white lysozyme at pH 8.0 in the presence of MPD
    M S Weiss
    Institute of Molecular Biotechnology, Department of Structural Biology and Crystallography, PO Box 100813, D 07708 Jena, Germany
    Acta Crystallogr D Biol Crystallogr 56:952-8. 2000
    ..The major reason for this is a molecule of MPD that binds tightly in between two lysozyme molecules and favors the growth of the crystals along the crystallographic c direction over growth perpendicular to it...
  6. ncbi Refolding SDS-denatured proteins by the addition of amphipathic cosolvents
    Catherine Michaux
    Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, 101 College Street, Toronto, Ontario, Canada
    J Mol Biol 375:1477-88. 2008
    ..MPD and related cosolvents can modulate the denaturing properties of SDS, and we describe a simple and effective method to recover refolded, active protein from the SDS-denatured state...
  7. ncbi Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia
    Magnus Bäck
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:17501-6. 2005
    ..Inhibition of LTB(4)/BLT(1) signaling during the response to vascular injury reduced intimal hyperplasia, suggesting this pathway as a possible target for therapy...
  8. ncbi Homologous desensitisation of the mouse leukotriene B4 receptor involves protein kinase C-mediated phosphorylation of serine 127
    Jens Mollerup
    Department of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
    Cell Physiol Biochem 20:143-56. 2007
    ..These data indicate that PKC-mediated phosphorylation at Ser-127 leads to mBLT1 desensitisation...
  9. ncbi Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival
    Jana Stankova
    Immunology Division, Department of Pediatrics, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Immunol 168:3570-6. 2002
    ....
  10. ncbi Blockade of leukotriene B4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer
    Aya Ihara
    Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Pharmacol Sci 103:24-32. 2007
    ..These results indicate that the blockade of the LTB(4)-signaling pathway induces apoptosis via the inhibition of ERK activation in colon cancer cells. The LTB(4)-signaling pathway might be a new therapeutic target for colon cancer...
  11. ncbi Endothelium-dependent vascular responses induced by leukotriene B4
    Magnus Bäck
    Department of Cardiology and Center for Molecular Medicine, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Prostaglandins Other Lipid Mediat 83:209-12. 2007
    ..Taken together, these results suggest that LTB(4) activates BLT(1) receptors on the endothelium of the guinea pig aorta, associated with the release of both contractile factors and NO...
  12. ncbi Interaction between pentaethylene glycol n-octyl ether and low-molecular-weight poly(acrylic acid)
    Gerardino D'Errico
    Chemistry Department of Naples University Federico II, Via Cintia, Complesso di Montesantangelo, I 80126 Naples, Italy
    J Colloid Interface Sci 270:490-5. 2004
    ..The peculiarities of the interaction between surfactants and low-molecular-weight polymers have been discussed...
  13. ncbi Physicochemical properties and in vitro biocompatibility of PEO/PTMO multiblock copolymer/segmented polyurethane blends
    Jae Hyung Park
    Center for Biomaterials and Biotechnology, Department of Materials Science and Engineering, Kwangju Institute of Science and Technology, South Korea
    J Biomater Sci Polym Ed 13:527-42. 2002
    ....
  14. ncbi Interactions of poly(amidoamine) dendrimers with the surfactants SDS, DTAB, and C12EO6: an equilibrium and structural study using a SDS selective electrode, isothermal titration calorimetry, and small angle neutron scattering
    J Sidhu
    School of Chemical Sciences, Science Research Institute, University of Salford, Salford M5 4WT, UK
    Langmuir 20:9320-8. 2004
    ..From the electromotive force (EMF) measurements, ITC data, and SANS data, the stoichiometry of the supramolecular complexes was determined...
  15. ncbi Fungal epoxide hydrolases: new landmarks in sequence-activity space
    Martha S Smit
    Department of Microbial, Biochemical and Food Biotechnology, University of the Free State, P O Box 339, Bloemfontein, 9300, South Africa
    Trends Biotechnol 22:123-9. 2004
    ..and A. niger stand out because we have sequence information as well as activity information for both the wild-type and recombinant forms of these enzymes...
  16. ncbi N7-guanine adducts of the epoxy metabolites of 1,3-butadiene in mice lung
    P Koivisto
    Finnish Institute of Occupational Health, The Chemistry Laboratory, Topeliuksenkatu 41 aA, FIN-00250 Helsinki, Finland
    Chem Biol Interact 135:363-72. 2001
    ..These are the crucial factors if interspecies differences in tumor sensitiveness is concerned...
  17. ncbi Translesion DNA synthesis by yeast DNA polymerase eta on templates containing N2-guanine adducts of 1,3-butadiene metabolites
    I G Minko
    Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston 77555-1071, USA
    J Biol Chem 276:2517-22. 2001
    ..Collectively, these data suggest that polymerase eta can tolerate the geometric distortions in DNA conferred by the N(2)-guanine butadiene monoadducts but not the intrastrand cross-links...
  18. ncbi Exploring the pharmacology of the leukotriene B4 receptor BLT1, without the confounding effects of BLT2
    Alan Sabirsh
    Medical Biochemistry and Biophysics, Karolinska Institute, MBB, Kemi II, 171 77 Stockholm, Sweden
    Eur J Pharmacol 499:53-65. 2004
    ..Inhibition of MAP kinases, Rho-associated kinases, or phosphoinositol-3-kinases (PI3K) had no effect on BLT1 receptor induced calcium signalling, and the receptor was insensitive to the redox state of the extracellular compartment...
  19. ncbi Involvement of the BLT2 receptor in the itch-associated scratching induced by 12-(S)-lipoxygenase products in ICR mice
    H J Kim
    Laboratory of Skin Research AmorePacific Corporation R and D Center, Gyeonggi Do, Korea
    Br J Pharmacol 154:1073-8. 2008
    ....
  20. ncbi Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation
    Makoto Arita
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Immunol 178:3912-7. 2007
    ..g., ChemR23-mediated counterregulatory actions) to mediate the resolution of inflammation...
  21. ncbi Development and biopharmaceutical evaluation of quinupramine-EVA matrix containing penetration enhancer for the enhanced transdermal absorption in rats
    Sang Chul Shin
    College of Pharmacy, Chonnam National University, Gwangju, Korea
    Pharm Dev Technol 12:429-36. 2007
    ..These results show that the quinupramine-EVA matrix containing a permeation enhancer could be a good transdermal delivery system for providing sustained plasma concentrations...
  22. ncbi Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    Br J Pharmacol 139:1351-9. 2003
    ....
  23. ncbi Movement of proteins in an environment crowded by surfactant micelles: anomalous versus normal diffusion
    Jedrzej Szymanski
    Institute of Physical Chemistry, Polish Academy of Sciences, Department III, Kasprzaka 44 52, 01 224 Warsaw, Poland
    J Phys Chem B 110:7367-73. 2006
    ..88 (at 37% surfactant). The fits for two-component normal diffusion and anomalous diffusion were of equally good quality, but the physical interpretation was only straightforward for the former...
  24. ncbi Mixed micellar systems of cleavable surfactants
    Dan Lundberg
    Applied Surface Chemistry, Department of Chemical and Biological Engineering, Chalmers University of Technology, , Sweden
    Langmuir 21:8658-63. 2005
    ..However, complementary experiments showed that it is possible to accelerate or retard the hydrolysis of TEO by coaggregation with stable cationic or anionic surfactants, respectively...
  25. ncbi Glycol porphyrin derivatives as potent photodynamic inducers of apoptosis in tumor cells
    Jarmila Kralova
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Med Chem 51:5964-73. 2008
    ..The strong interaction with a tumor marker (sialic acid) indicates the preferential association of these compounds with tumor cells...
  26. ncbi Ceriporic acid C, a hexadecenylitaconate produced by a lignin-degrading fungus, Ceriporiopsis subvermispora
    Rudianto Amirta
    Laboratory of Biomass Conversion, Wood Research Institute, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan
    Chem Phys Lipids 126:121-31. 2003
    ..Thus, it was found that ceriporic acids share close structural similarity with alk(en)yl citraconate derivatives, chaetomellic acids and other lichen lactones, protolichesterinic, lichesterinic, and murolic acids...
  27. ncbi Stereochemical determination of thuggacins A-C, highly active antibiotics from the myxobacterium Sorangium cellulosum
    Martin Bock
    , , Schneiderberg 1B, 30167 Hannover, Germany
    Angew Chem Int Ed Engl 47:2308-11. 2008
  28. ncbi Synthesis and absolute configuration assignment of 5-amino-1,3,5-triphenyl-pentane-1,3-diol stereoisomers
    Cornelia Uncuta
    Center of Organic Chemistry C.D. Nenitzescu, Bucharest, Romania
    Chirality 17:63-72. 2005
    ..2-Isoxazoline ketone 2 enantiomers and isoxazoline alcohol 3 enantiomers were obtained by chiral HPLC on Chiralpak AD column. 2-Isoxazoline ketone 2 enantiomers can be racemized via a retro Michael addition...
  29. ncbi Asymmetric desymmetrization based on an intramolecular haloetherification: a highly effective and recyclable chiral nonracemic auxiliary, 2-exo-methyl-3-endo-phenyl-5-norbornene-2-carboxaldehyde, for meso-1,3- and meso-1,4-diols
    Hiromichi Fujioka
    Graduate School of Pharmaceutical Sciences, Osaka University, 1 6, Yamada oka, Suita, Osaka, 565 0871, Japan
    Chemistry 10:5386-97. 2004
    ....
  30. ncbi A simple glycol nucleic acid
    Lilu Zhang
    Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, USA
    J Am Chem Soc 127:4174-5. 2005
    ..A glycol nucleic acid (GNA) with an acyclic propylene glycol phosphodiester backbone forms stable antiparallel duplexes following the Watson-Crick base pairing rules...
  31. ncbi Structure of a site specific major groove (2S,3S)-N6-(2,3,4-trihydroxybutyl)-2'-deoxyadenosyl DNA adduct of butadiene diol epoxide
    Tandace A Scholdberg
    Department of Chemistry, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, USA
    Chem Res Toxicol 17:717-30. 2004
    ..Overall, the structure of this adduct is consistent with an emerging pattern in which major groove adenine N(6) alkylation products of styrene and butadiene oxides that do not strongly perturb DNA structure are not strongly mutagenic...
  32. ncbi Detection of carboxylic acids and inhibition of hippuric acid formation in rats treated with 3-butene-1,2-diol, a major metabolite of 1,3-butadiene
    Christopher L Sprague
    School of Veterinary Medicine, 2015 Linden Drive, Madison, WI 53706, USA
    Drug Metab Dispos 31:986-92. 2003
    ..The detection of 1-hydroxy-2-butanone and the carboxylic acids also provides insight regarding pathways of BDD metabolism in vivo...
  33. ncbi Mutations induced by 1,3-butadiene metabolites, butadiene diolepoxide, and 1,2,3,4-diepoxybutane at the Hprt locus in CHO-K1 cells
    Dong-Hyun Lee
    Department of Biochemistry and Institute of Natural Sciences, College of Natural Sciences, Yeungnam University, Kyongsan 712-749, Korea
    Mol Cells 14:411-9. 2002
    ..These data indicate that BDE and DEB are mutagenic carcinogens by forming DNA adducts at the site of adenine and guanine, and inducing large exon deletions and single base substitutions...
  34. ncbi Development of a physiologically based toxicokinetic model for butadiene and four major metabolites in humans: global sensitivity analysis for experimental design issues
    Celine Brochot
    INERIS, Institut National de l Environnement Industriel et des Risques, Unité de Toxicologie Expérimentale, Parc Alata BP2, 60550 Verneuil en Halatte, France
    Chem Biol Interact 167:168-83. 2007
    ....
  35. ncbi Measurement of plasma or urinary metabolites and Hprt mutant frequencies following inhalation exposure of mice and rats to 3-butene-1,2-diol
    Dale M Walker
    Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Chem Biol Interact 166:191-206. 2007
    ....
  36. ncbi Mispairing of a site specific major groove (2S,3S)-N6-(2,3,4-trihydroxybutyl)-2'-deoxyadenosyl DNA Adduct of butadiene diol epoxide with deoxyguanosine: formation of a dA(anti).dG(anti) pairing interaction
    Tandace A Scholdberg
    Department of Chemistry, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, USA
    Chem Res Toxicol 18:145-53. 2005
    ..R., Nechev, L. N., Harris, C. M., Harris, T. M., and Lloyd, R. S. (2000) Env. Mol. Mutagen. 35, 48-56]...
  37. ncbi Metabolism of 1,3-butadiene to toxicologically relevant metabolites in single-exposed mice and rats
    Johannes Georg Filser
    Institute of Toxicology, GSF National Research Center for Environment and Health, D 85764 Neuherberg, Germany
    Chem Biol Interact 166:93-103. 2007
    ..At higher BD concentrations EBD blood concentrations decreased again. This picture probably results from a competitive inhibition of the EBD producing CYP450 by BD, which occurs in both species...
  38. ncbi New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo
    Amnon C Sintov
    The Institutes for Applied Research, Ben Gurion University of the Negev, P O Box 653, Beer Sheva 84105, Israel
    J Control Release 95:173-83. 2004
    ..water) or patches compared to those measured after application of EMLA cream. It has been suggested, therefore, that these microemulsions loaded with lidocaine would provide adequate analgesia in relatively shorter periods of time...
  39. ncbi Preparation and evaluation of bioadhesive benzocaine gels for enhanced local anesthetic effects
    Sang Chul Shin
    College of Pharmacy, Chonnam National University, 300 Yongbongdong Bukku, Kwangju 500 757, South Korea
    Int J Pharm 260:77-81. 2003
    ..The permeation rate of drug through the skin was studied using various enhancers, such as glycols, non-ionic surfactants or fatty acids...
  40. ncbi Protecting role of cosolvents in protein denaturation by SDS: a structural study
    Catherine Michaux
    Chemistry Department, CBS lab, CPTS group, 61 rue de Bruxelles, B 5000 Namur, Belgium
    BMC Struct Biol 8:29. 2008
    ..Although the persistence of the protein activity in the SDS/MPD mixture was clearly established, preservation of their structure was only speculative until now...
  41. ncbi Gene transfer with three amphiphilic glycol chitosans--the degree of polymerisation is the main controller of transfection efficiency
    Ijeoma F Uchegbu
    Department of Pharmaceutical Sciences, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, Glasgow, UK
    J Drug Target 12:527-39. 2004
    ....
  42. ncbi Addition of polyglycol to old culture of Phanerochaete chrysosporium
    Irena Grgic
    Faculty of Chemistry and Chemical Technology, University of Ljubljana, Askerceva 5, SJ 1000, Ljubljana, Slovenia
    Appl Biochem Biotechnol 112:91-100. 2004
    ..In old fungus, the incompatibility of polyglycols and glycans decreases the adsorption and the effect of high mol wt polyglycols...
  43. ncbi Sugar bislactones by one-step oxidative dimerisation with pyridinium chlorochromate versus regioselective oxidation of vicinal diols
    Amélia P Rauter
    Departamento de Quimica e Bioquimica, Faculdade de Ciencias da Universidade de Lisboa, Ed C8, 5 degrees piso, Campo Grande, 1749 016 Lisboa, Portugal
    Carbohydr Res 339:1889-97. 2004
    ..The bislactone presenting pivaloyl protecting groups also promoted some growth inhibition of Staphylococcus aureus...
  44. ncbi New method for synthesizing the intermediates to 5-HETE from yeast-mediated reduction products by employing Baeyer-Villiger oxidation with complete retention of enantiomeric excess
    Satoshi Yamauchi
    Faculty of Agriculture, Ehime University, Matsuyama, Japan
    Biosci Biotechnol Biochem 67:1959-69. 2003
    ....
  45. ncbi Highly efficient synthesis of enantiopure diacetylated C(2)-symmetric diols by ruthenium- and enzyme-catalyzed dynamic kinetic asymmetric transformation (DYKAT)
    Belén Martín-Matute
    Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691 Stockholm, Sweden
    Chemistry 12:6053-61. 2006
    ..The in situ coupling of these two processes produces the diacetates in high yield in >99 % enantiomeric excess...
  46. ncbi Expression, purification, and aggregation studies of His-tagged thermoalkalophilic lipase from Bacillus thermocatenulatus
    Nils Helge Schlieben
    , , , , Germany
    Protein Expr Purif 34:103-10. 2004
    ..For the concentrated lipase, the availability of 5% 2-propanol was sufficient to hold the lipase in monomeric form and no additional detergent was needed...
  47. ncbi Long-range stereo-relay: relative and absolute configuration of 1,n-glycols from circular dichroism of liposomal porphyrin esters
    John B Macmillan
    Department of Chemistry, One Shields Avenue, University of California, Davis, California 95616, USA
    J Am Chem Soc 126:9944-5. 2004
    The relative and absolute configurations of long-chain syn- and anti-1,5-, 1,7- and 1,9-glycols were determined from exciton-coupled circular dichroism (ECCD) of the corresponding bis-5-(4'-carboxyl)-5,10,15,20-tetraphenylporphyrin ..
  48. ncbi An efficient, palladium-catalyzed, enantioselective synthesis of (2R)-3-butene-1,2-diol and its use in highly selective Heck reactions
    Natasha Cheeseman
    Dowpharma, Chirotech Technology Ltd, Dow Chemical Company, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, United Kingdom
    Proc Natl Acad Sci U S A 101:5396-9. 2004
    ..Subsequent Heck reactions with a diverse range of coupling partners are described and the influence of their electronic nature on maintaining the enantiopurity of the diol is discussed...
  49. ncbi Determination of absolute configuration of acyclic 1,2-diols with Mo2(OAc)4. 1. Snatzke's method revisited
    L Di Bari
    Centro di Studio del CNR per le Macromolecole Stereordinate e Otticamente Attive, Dipartimento di Chimica e Chimica Industriale, , Via Risorgimento 35, I-56126 Pisa, Italy
    J Org Chem 66:4819-25. 2001
    ..The roles of the water content of the sample and of the diol-to-dimolybdenum ratio are investigated...
  50. ncbi A convenient and chemoselective one-pot oxidation/Wittig reaction for the C2-homologation of carbohydrate-derived glycols
    Fernando R Pinacho Crisóstomo
    Instituto Universitario de Bioorgánica Antonio González, Universidad de La Laguna, Astrofisico Francisco Sanchez 2, 38206 La Laguna, Tenerife, Islas Canarias, Spain
    J Org Chem 70:10099-101. 2005
    ..see text] A simple and convenient one-pot protocol for the chemoselective C2-homologation of carbohydrate-derived glycols is described...
  51. ncbi Diastereoselective synthesis of optically active (2 R,5 R)-hexanediol
    J Haberland
    , Institute of Biotechnology, , Germany
    Appl Microbiol Biotechnol 58:595-9. 2002
    ..The applicability of the system in fed-batch experiments was demonstrated. The feed specific biomass concentration required to reach maximal yield and selectivity in fed-batch mode was determined...
  52. ncbi ESI-MS/MS for the differentiation of diastereomeric pyrimidine glycols in mononucleosides
    Yinsheng Wang
    Department of Chemistry, University of California at Riverside, 92521 0403, USA
    Anal Chem 74:4505-12. 2002
    Pyrimidine glycols, or 5,6-dihydroxy-5,6-dihydropyrimidines, are primary lesions in DNA induced by reactive oxygen species...
  53. ncbi Hydrogels based on poly(ethylene oxide) and poly(tetramethylene oxide) or poly(dimethyl siloxane). III. In vivo biocompatibility and biostability
    Jae Hyung Park
    Center for Biomaterials and Biotechnology, Department of Materials Science and Engineering, Kwangju Institute of Science and Technology, 1 Oryong-dong, Puk-gu, Kwangju 500-712, South Korea
    J Biomed Mater Res A 64:309-19. 2003
    ..It was evident that the minor degradation could be achieved by grafting PEO and adopting PDMS as a hydrophobic block in the hydrogel...
  54. ncbi Wear comparison of thermoplastic materials used for orthodontic retainers
    Gary D Gardner
    Research and Biomaterials, Lackland Air Force Base, San Antonio, TX 78236, USA
    Am J Orthod Dentofacial Orthop 124:294-7. 2003
    ..There was no evidence to suggest a difference in mean wear between the 2 polypropylene-based materials (P >.05)...
  55. ncbi Exclusion of alcohols from spermidine-DNA assemblies: probing the physical basis of preferential hydration
    Anne Hultgren
    Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 43:8272-80. 2004
    ..The exclusion measured for these condensed arrays can quantitatively account for the effect of these alcohols on the precipitation of DNA from dilute solution by spermidine(3+)...
  56. ncbi In vivo monitoring of intravenously injected gold nanorods using near-infrared light
    Takuro Niidome
    Department of Applied Chemistry, Kyushu University, 744 Moto oka, Nishi ku, Fukuoka 819 0395, Japan
    Small 4:1001-7. 2008
    ..3-min half-life. In vivo spectral changes of gold nanorods depend on the surface characteristics, and can be observed in real time using simple spectroscopic measurements...
  57. ncbi Analytical investigations on a releasing agent application in aluminium diecasting
    Hubertus Wichmann
    Institute of Ecological Chemistry and Waste Analysis, Technical University of Braunschweig, Hagenring 30, 38106 Braunschweig, Germany
    Environ Sci Pollut Res Int 12:227-32. 2005
    ....
  58. ncbi Literature review--efficacy of various disinfectants against Legionella in water systems
    B R Kim
    Ford Research Laboratory, Dearborn, MI 48121, USA
    Water Res 36:4433-44. 2002
    ..thiocarbamates, aldehydes, amines, thiocyanates, organo-tin compounds, halogenated amides, and halogenated glycols), and UV light. In general, oxidizing disinfectants were found to be more effective than non-oxidizing ones...
  59. ncbi Shigella-induced necrosis and apoptosis of U937 cells and J774 macrophages
    Takashi Nonaka
    Division of Cell Biology and Biochemistry, Department of Basic Medical Sciences, The Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Microbiology 149:2513-27. 2003
    ..Osmoprotectants such as polyethylene glycols could suppress cell death, suggesting that insertion of a pore by Shigella into the host cell membrane induces ..
  60. ncbi [Biochemical and molecular characterization of Salmonella serovar enteritidis phage type 4 isolated from food poisoning outbreaks in Tokyo]
    J Kusunoki
    Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health
    Kansenshogaku Zasshi 71:730-7. 1997
    ..and vehicle foods, eggs and environment in Tokyo were examined for plasmid DNA profiles, acid productivity from glycols (propylene and ethylene) and antimicrobial resistance patterns...
  61. ncbi In vitro and in vivo evaluation of polyoxyethylene esters as dermal prodrugs of ketoprofen, naproxen and diclofenac
    F P Bonina
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Eur J Pharm Sci 14:123-34. 2001
    ..These esters were obtained by coupling these drugs with polyoxyethylene glycols by a succinic acid spacer...
  62. ncbi Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases
    Bensu Karahalil
    Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 278:33701-7. 2003
    ..We show that mNTH1 is responsible for the repair of thymine glycols in mitochondrial DNA, whereas other glycosylase/AP lyases also participate in removing other oxidized pyrimidines,..
  63. ncbi Development and characterization of Ni-NTA-bearing microspheres
    Sabine A Lauer
    Bioscience Division and National Flow Cytometry Resource, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
    Cytometry 48:136-45. 2002
    ....
  64. ncbi Development of the ambroxol gels for enhanced transdermal delivery
    Cheong Weon Cho
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Drug Dev Ind Pharm 34:330-5. 2008
    ..The rate of drug permeation into the skin was enhanced by incorporating various enhancers such as the ethylene glycols, the propylene glycols, the glycerides, the non-ionic surfactants, and the fatty acids into the gels...
  65. ncbi Oxidation reactions of cytosine DNA components by hydroxyl radical and one-electron oxidants in aerated aqueous solutions
    J Richard Wagner
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    Acc Chem Res 43:564-71. 2010
    ..5-Hydroxypyrimidines, the dehydration products of cytosine and uracil glycols, have a low oxidation potential, and their one-electron oxidation results in a cascade of decomposition reactions ..
  66. ncbi Ultrafiltration separation of aquatic natural organic matter: chemical probes for quality assurance
    Alex D Revchuk
    Environmental Science and Engineering Program, University of California Los Angeles, CA 90095 1772, USA
    Water Res 43:3685-92. 2009
    ..The probes used to represent the size, shape and charge of NOM were polymers (polyethylene glycols (PEGs), dextrans, polystyrene sulfonates (PSSs)), dyes (bromocresol green, congo red, methyl red, methyl orange) ..
  67. ncbi Effect of polyethylene glycols on the function and structure of thiol proteases
    Sadaf Fatima
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202 002, India
    J Biochem 142:65-72. 2007
    ..The results imply that caution must be exercised in the use of PEGs with thiol proteases or hydrophobic proteins in general, for different industrial applications, even at room temperature...
  68. ncbi Biodegradability relationships among propylene glycol substances in the Organization for Economic Cooperation and Development ready- and seawater biodegradability tests
    Robert J West
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, Michigan 48674, USA
    Environ Toxicol Chem 26:862-71. 2007
    ..decreased with increased number of oxy-propylene repeating units (n = 1, 2, 3, 4) of the oligomeric propylene glycols (PGs)...
  69. ncbi [Therapeutic effects of chitosan/polyethylene glycols-succinate/mitomycin C film drug delivery system on epidural scarring tissues after laminectomy of SD rats]
    Yu Zhang
    Department of Orthopaedics, Zhujiang Hospital, Southern Medical University, Guangzhou Guangdong 510282, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 22:1222-6. 2008
    To investigate the therapeutic effect of the chitosan/polyethylene glycols-succinate/ mitomycin C (CH/PEG-SA/MMC) film on epidural scarring tissues.
  70. ncbi Formation of lysophospholipids from unsaturated phosphatidylcholines under the influence of hypochlorous acid
    J Arnhold
    Institute of Medical Physics and Biophysics, Medical Department, University of Leipzig, Liebigstr 27, D 04103 Leipzig, Germany
    Biochim Biophys Acta 1572:91-100. 2002
    ..considerably in comparison to the total amount of higher molecular weight products like chlorohydrins and glycols. High amounts of lysophosphatidylcholines were formed from phospholipids containing arachidonic or ..
  71. ncbi Reactions of oxalyl chloride with 1,2-cycloalkanediols in the presence of triethylamine
    Taisuke Itaya
    Faculty of Pharmaceutical Sciences, Kanazawa University, Japan
    Chem Pharm Bull (Tokyo) 50:83-6. 2002
    ..of triethylamine at 0 degrees C has been shown analogous to that obtained for 1,2-disubstituted acyclic ethylene glycols 1: cis-1,2-cyclooctanediol (9f) produced the cyclic oxalate 14f as the major product, while trans-1,2-..
  72. ncbi Thymine glycols and pyrimidine dimers in brain DNA during post-ischemic reperfusion
    G S Krause
    Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI 48201
    Resuscitation 21:41-55. 1991
    ..We therefore examined the hypothesis that thymine glycols and thymine dimers, which are known to block transcription and are formed by free radical mechanisms, are formed ..
  73. ncbi Solubility enhancement of Cox-2 inhibitors using various solvent systems
    N Seedher
    Department of Chemistry, Panjab University, Chandigarh 160014, India
    AAPS PharmSciTech 4:E33. 2003
    ..Water, alcohols, glycols, glycerol, and polyethylene glycol 400 (PEG 400) were used as solvents and water-ethanol, glycerol-ethanol, and ..
  74. ncbi [Biochemical and molecular characterization of Salmonella ser. enteritidis phage type 1 isolated from food poisoning outbreaks in Tokyo]
    J Kusunoki
    Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health
    Kansenshogaku Zasshi 73:437-44. 1999
    ..from 44 outbreaks between 1990 and 1996 were examined for antimicrobial resistance, acid producibility from glycols (propylene and ethylene glycol) and plasmid DNA profiles...
  75. ncbi Effect of molecular weight and end-group nature on the solubility of ethylene oxide oligomers in 2H, 3H-decafluoropentane and its fully fluorinated analogue, perfluoropentane
    Marie Cote
    School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK
    J Pharm Pharmacol 60:593-9. 2008
    ..Over a wide range of temperatures and concentrations, dihydroxyl end-capped poly(ethylene glycols) (PEGs) exhibited a lower critical solution temperature (LCST) that was strongly molecular weight dependent...
  76. ncbi Radiolabeling and targeting of lipidic nanocapsules for applications in radioimmunotherapy
    E Jestin
    INSERM, U 601, University of Nantes, Nantes, France
    Q J Nucl Med Mol Imaging 51:51-60. 2007
    ....
  77. ncbi Antimutagenic role of base-excision repair enzymes upon free radical-induced DNA damage
    J Laval
    Groupe Reparation des lesions Radio et Chimio Induites, URA 147 CNRS, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    Mutat Res 402:93-102. 1998
    ..as C8-oxoguanine and purines whose imidazole ring is opened), oxidised pyrimidines (such as thymine and cytosine glycols, ring saturated and fragmented pyrimidines), ethenobases and hypoxanthine...
  78. ncbi DNA repair in specific sequences in mammalian cells
    C A Smith
    Department of Biological Sciences, Stanford University, CA 94305 5020
    J Cell Sci Suppl 6:225-41. 1987
    ..The removal of thymine glycols from alpha DNA in gamma-irradiated cells is proficient, as is repair synthesis elicited by exposure to methyl ..
  79. ncbi Solidification studies of polyethylene glycols, gelucire 44/14 or their dispersions with triamterene or temazepam
    S K Dordunoo
    Drug Delivery and Pharmaceutical Technology Group, School of Pharmacy and Chemistry, Liverpool John Moores University, UK
    J Pharm Pharmacol 48:782-9. 1996
    The solidification of polyethylene glycols (PEG 1500, PEG 2000, PEG 4000, PEG 6000), gelucire 44/14 or their dispersions containing triamterene or temazepam were studied to assess the feasibility of using these dispersions to liquid-fill ..
  80. ncbi Nonionic polymers reverse inactivation of surfactant by meconium and other substances
    H William Taeusch
    Departments of Pediatrics and Physiology, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA
    Am J Respir Crit Care Med 159:1391-5. 1999
    ..inactivation of surfactant could be prevented or reduced by nonionic polymers, we added dextrans, polyethylene glycols (PEGs), or polyvinylpyrrolidones (PVPs) of various molecular weights to pulmonary surfactants...
  81. ncbi Chemical imaging of catalyst deactivation during the conversion of renewables at the single particle level: etherification of biomass-based polyols with alkenes over H-Beta zeolites
    Andrei N Parvulescu
    Inorganic Chemistry and Catalysis Group, Debye Institute for NanoMaterials Science, Utrecht University, Sorbonnelaan 16, 3508 TB Utrecht, The Netherlands
    J Am Chem Soc 132:10429-39. 2010
    ..This allowed us to explain the influence of the substrate type (glycerol, glycols, and alkenes) and zeolite properties (Si/Al ratio and particle size) on the etherification activity...
  82. ncbi Preparation and evaluation of bioadhesive dibucaine gels for enhanced local anesthetic action
    Chung Kang
    College of Pharmacy, Chonnam National University, Gwangju, 500 757, Korea
    Arch Pharm Res 33:1277-83. 2010
    ..We investigated the enhancing effects on drug permeation into skins, using some kind of enhancers such as the glycols, the non-ionic surfactants, the fatty acids, and the propylene glycol derivatives...
  83. ncbi Enhanced transdermal delivery of loratadine from the EVA matrix
    Cheong Weon Cho
    Chungnam National University, Daejeon, South Korea
    Drug Deliv 16:230-5. 2009
    Various enhancers, such as fatty acids (saturated, unsaturated), glycerides, propylene glycols, and non-ionic surfactants, have been incorporated in the loratadine-EVA matrix to increase the rate of skin permeation of loratadine from an ..
  84. ncbi Pore size of swelling-activated channels for organic osmolytes in Jurkat lymphocytes, probed by differential polymer exclusion
    Vladimir L Sukhorukov
    Lehrstuhl fur Biotechnologie, Biozentrum der Universität Würzburg, Am Hubland, D 97074 Wurzburg, Germany
    Biochim Biophys Acta 1788:1841-50. 2009
    The present study explores the impact of the molecular size on the permeation of low-molecular-weight polyethylene glycols (PEG200-1500) through the plasma membrane of Jurkat cells under iso- and hypotonic conditions...
  85. ncbi Settlement and adhesion of algal cells to hexa(ethylene glycol)-containing self-assembled monolayers with systematically changed wetting properties
    Soeren Schilp
    Angewandte Physikalische Chemie, Universitat Heidelberg, INF, Heidelberg, Germany
    Biointerphases 2:143-50. 2007
    Protein resistance of self-assembled monolayers (SAMs) of hexa(ethylene glycols) (EG(6)) has previously been shown to be dependent on the alkoxyl end-group termination of the SAM, which determines wettability [S. Herrwerth, W. Eck, S...
  86. ncbi Polyethylene glycols interact with membrane glycerophospholipids: is this part of their mechanism for hypothermic graft protection?
    Delphine Dutheil
    Inserm U927, Poitiers, France
    J Chem Biol 2:39-49. 2009
    ..This study sheds a new light on PEG protective effects during organ preservation different from all classical hypotheses...
  87. ncbi [An update on the use of tissue adhesives in ophthalmology]
    L Vera
    Service d Ophtalmologie, Hopital Charles Nicolle, boulevard Gambetta, Rouen, France
    J Fr Ophtalmol 32:290-305. 2009
    ..Novel biomaterials such as biodendrimers, polyethylene glycols, modified chondroitin sulfates, and acrylic copolymers show promising results in the experimental field, and one ..
  88. ncbi A positive chemical ionization GC/MS method for the determination of airborne ethylene glycol and propylene glycols in non-occupational environments
    Jiping Zhu
    Chemistry Research Division, Health Canada, AL 0800C, EHC Building, Tunney s Pasture, Ottawa, Canada K1A 0L2
    J Environ Monit 6:881-7. 2004
    An analytical method for ethylene glycol and propylene glycols has been developed for measuring airborne levels of these chemicals in non-occupational environments such as residences and office buildings...
  89. ncbi High mass clearance of autoantibodies from a murine model of lupus nephritis by immunoadsorption using star-configured polyethylene glycols
    E A Ross
    Division of Nephrology, Hypertension and Transplantation, College of Medicine, University of Florida, Gainesville 32610 0224, USA
    J Biomed Mater Res 55:114-20. 2001
    ..To overcome these shortcomings, we designed a method utilizing star-configured polyethylene glycols (star-PEGs) having up to 63 free arms with immunoreactive (tresylate ester) end-groups for each arm immobilized ..
  90. ncbi Aerobic biodegradation of polyethylene glycols of different molecular weights in wastewater and seawater
    Marco Bernhard
    University of Applied Sciences Fresenius, Limburger Strasse 2, D 65510 Idstein, Germany
    Water Res 42:4791-801. 2008
    In order to distinguish between aerobic biodegradation of synthetic polymers in fresh and seawater, polyethylene glycols (PEGs) were systematically and comparatively investigated in inocula from municipal wastewater and seawater aquarium ..
  91. ncbi Modeling and measurements of solid-liquid and vapor-liquid equilibria of polyols and carbohydrates in aqueous solution
    Svava Osk Jónsdóttir
    Department of Chemistry, Technical University of Denmark, Building 207, DK 2800, Lyngby, Denmark
    Carbohydr Res 337:1563-71. 2002
    ..mechanics methods has shown to give good predictions of the phase behavior of a variety of mixtures, including glycols and small saccharides in aqueous solution...
  92. ncbi Spectral characterization and colloidal properties of 1-hexadecylpyridinium chloride in aqueous binary mixtures of different glycols
    S K Mehta
    Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, India
    J Colloid Interface Sci 333:646-54. 2009
    ..Temperature studies were performed in aqueous mixtures of ethylene, diethylene, triethylene and tetraethylene glycols (abbreviated as EG, DEG, TEG and TeEG, respectively)...
  93. ncbi Determination of the pore size distribution and porosity of aerobic granules using size-exclusion chromatography
    Yu Ming Zheng
    School of Chemistry, University of Science and Technology of China, Hefei 230026, China
    Water Res 41:39-46. 2007
    ..granules with different diameters were evaluated using size-exclusion chromatography, in which polyethylene glycols and distilled water were, respectively, used as solute and mobile phase...
  94. ncbi Virtual colonoscopy: a new promising technique
    P Vavra
    Department of Surgery, University Hospital Ostrava, Ostrava Poruba, Czech Republic
    Bratisl Lek Listy 108:442-4. 2007
    ..Virtual colonoscopy is less invasive than conventional colonoscopy and does not require a conscious sedation...
  95. ncbi Synthesis of pH-sensitive amphotericin B-poly(ethylene glycol) conjugates and study of their controlled release in vitro
    Miloš Sedlák
    Department of Organic Chemistry, University of Pardubice, Cs legií 565, 532 10 Pardubice, Czech Republic
    Bioorg Med Chem 15:4069-76. 2007
    New intravenous conjugates of amphotericin B (AMB) with poly(ethylene glycols) (PEG) (M=5000, 10,000, 20,000) have been synthesized and characterised...
  96. ncbi [Immunoresonance scattering spectral assay for the determination of antithrombin-III]
    Bo Jiang
    School of Environment and Resource, Guangxi Normal University, Guilin 541004, China
    Guang Pu Xue Yu Guang Pu Fen Xi 28:1145-8. 2008
    ..50 x 10(2) ng x mL(-1) AT-III, when the relative error was within +/- 10%. Four polyethelene glycols, i. e...
  97. ncbi Dual regulation of a polyethylene glycol degradative operon by AraC-type and GalR-type regulators in Sphingopyxis macrogoltabida strain 103
    Jittima Charoenpanich
    Research Institute for Bioresources, Okayama University, 2 20 1 Chuo, Kurashiki, Okayama 710 0046, Japan
    Microbiology 152:3025-34. 2006
    ..A promoter activity assay showed that the pegB promoter was induced by PEG and oligomeric ethylene glycols, whereas the pegA and pegR promoters were induced by PEG...
  98. ncbi Through pore diameter in the cell wall of Chara corallina
    G N Berestovsky
    Institute of Cell Biophysics RAS, Pushchino, Moscow Region 142290, Russia
    J Exp Bot 52:1173-7. 2001
    ..The determination of gamma(p), for polydisperse polyethylene glycols with different average molecular mass (M) was calculated from the degree of pressure restoration after water was ..
  99. ncbi [Macroprolactin as etiology of hyperprolactinemia. Method for detection and clinical characterization of the entity in 39 patients]
    L García Menéndez
    Servicio de Analisis Clinicos, Hospital del Bierzo, Leon
    Rev Clin Esp 203:459-64. 2003
    ..The precipitation with polyethylene glycols permits its detection rapidly, trustworthily, and inexpensively...
  100. ncbi Physical stability of solid dispersions containing triamterene or temazepam in polyethylene glycols
    S K Dordunoo
    Drug Delivery and Pharmaceutical Technology Group, School of Pharmacy and Chemistry, Liverpool John Moores University, UK
    J Pharm Pharmacol 49:390-6. 1997
    The effect of storage on the physical stability of solid dispersions of triamterene or temazepam in polyethylene glycols was studied using differential scanning calorimetry (DSC), particle-size analysis and dissolution methods...
  101. ncbi Effects of powder particle size and binder viscosity on intergranular and intragranular particle size heterogeneity during high shear granulation
    Torben Schaefer
    Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    Eur J Pharm Sci 21:525-31. 2004
    ..5-63.1 microm. Each of three polyethylene glycols (PEGs) having viscosities in the range of approximately 40-14,000 mPas were applied as meltable binders...

Research Grants82

  1. TRANSCRIPTION COUPLED REPAIR IN EUKARYOTIC CELLS
    STEVEN LEADON; Fiscal Year: 1999
    ..Using an immunological approach, the repair of thymine glycols (a strong block to RNA polymerase), 8-oxo-guanine (an intermediate block), and 8-oxo-adenine (a weak block) will ..
  2. MOLECULAR BARRIERS TO THROMBOSIS ON TISSUE SURFACES
    William Wagner; Fiscal Year: 2002
    ..Preliminary data indicates that polyethylene glycols (PEGs) with end groups reactive toward proteins can be applied to damaged arterial segments under conditions and ..
  3. Overexpression and crystallization of amino acid transp*
    Da Neng Wang; Fiscal Year: 2002
    ..Crystal nucleation will be screened with various polyethylene glycols and pHs...
  4. PEGylated Prolactin Receptor Antagonists as Cancer Drugs
    MERRY SHERMAN; Fiscal Year: 2002
    ..Polymer conjugates of PRLA will be synthesized containing 1-3 strands of linear or branched poly(ethylene glycols) (PEGs) of various molecular weights (10-60 kDa), linked by various chemistries...
  5. Processing of Radiation Damage by Translesion DNA Synthesis
    Susan Wallace; Fiscal Year: 2007
    ..Sites of base loss and thymine glycols are frequently produced and replication blocking DNA damages while 5-hydroxycytosine, 8-oxoguanine and 2-..
  6. Processing of Radiation Damage by Translesion DNA Synthesis
    SYLVIE DOUBLIE; Fiscal Year: 2010
    ..Sites of base loss and thymine glycols are frequently produced and replication blocking DNA damages while 5-hydroxycytosine, 8-oxoguanine and 2-..
  7. ROS-induced Nucleic Acid Damage
    Yinsheng Wang; Fiscal Year: 2006
    ..The outcome of the research proposed here will provide better understanding of the biological consequences of oxidative damage on nucleic acids by ROS and their implications in human health. ..
  8. Oxidative Crosslink Lesions and CpG Mutagenesis
    Yinsheng Wang; Fiscal Year: 2007
    ..The outcome of the proposed research will provide important insights into the roles of these crosslink lesions in CpG mutagenesis. ..
  9. Chemistry and Biology of DNA Carboxyalkylation
    Yinsheng Wang; Fiscal Year: 2010
    ..and exposure to N-nitroso compounds in the etiology of diabetic complications and gastrointestinal tumors, and lead to the discovery of novel molecular biomarkers and risk factors for developing these pathological conditions ..
  10. Chemistry and Biology of DNA Carboxyalkylation
    Yinsheng Wang; Fiscal Year: 2010
    ..and exposure to N-nitroso compounds in the etiology of diabetic complications and gastrointestinal tumors, and lead to the discovery of novel molecular biomarkers and risk factors for developing these pathological conditions ..
  11. Post-translational Modifications of High-mobility Group Proteins
    Yinsheng Wang; Fiscal Year: 2009
    ..In addition, the outcome of proposed studies may provide important molecular biomarkers for cancer diagnosis and prognosis. ..
  12. Post-translational Modifications of High-mobility Group Proteins
    Yinsheng Wang; Fiscal Year: 2009
    ..In addition, the outcome of proposed studies may provide important molecular biomarkers for cancer diagnosis and prognosis. ..
  13. LONG-ACTING G-CSF PROTEINS FOR TREATING NEUTROPENIA
    George Cox; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATION: Not Available ..
  14. Polymer-Surfactant Therapy in Rat Models of ARDS
    HWILLIAM TAEUSCH; Fiscal Year: 2010
    ..Overall this project will not only develop a promising new therapy of ALI/ARDS, but will also foster basic understanding of mechanisms of surfactant inhibition and ways to overcome it. ..
  15. Cytoskeleton polymerization dynamics in the cell cycle
    Timothy J Mitchison; Fiscal Year: 2010
    ..Understanding midbody assembles will reveal principles for generating asymmetric assemblies in the cytoplasm, and will tell us how the cleavage furrow is positioned. ..
  16. ELECTRON MICROSCOPE
    Timothy Mitchison; Fiscal Year: 2004
    ..The automated controls and digital image acquisition will also be optimal for introducing new users to electron microscopy and for minimizing maintenance requirements that might arise from operator inexperience. ..
  17. Long Acting VEGF Binding Proteins for Treating Rheumatoid Arthritis
    George Cox; Fiscal Year: 2007
    ..VEGF inhibitors have been tested in humans and have been shown to delay the progression of the disease. Our overall goal is to create a long acting VEGF inhibitor that can be dosed once a week or once every two weeks. ..
  18. ACTIN DYNAMICS AND CELL LOCOMOTION
    Timothy Mitchison; Fiscal Year: 2004
    ..For perturbation experiments we will use protein tools, and also cell permeable chemicals coming out of a screening effort at the Harvard Institute of Chemistry and Cell Biology (ICCB). ..
  19. Polymer-Surfactant Therapy in Rat Models of ARDS
    Karen Lu; Fiscal Year: 2007
    ..Overall this project will not only develop a promising new therapy of ALI/ARDS, but will also foster basic understanding of mechanisms of surfactant inhibition and ways to overcome it. ..
  20. Cytoskeleton polymerization dynamics in the cell cycle
    Timothy Mitchison; Fiscal Year: 2009
    ..These will provide biomarkers for understanding how anti-mitotic drugs work or fail in cancer therapy, as well as opening new avenues in cell cycle research. ..
  21. Cytoskeleton polymerization dynamics in the cell cycle
    Timothy Mitchison; Fiscal Year: 2007
    ..Understanding midbody assembles will reveal principles for generating asymmetric assemblies in the cytoplasm, and will tell us how the cleavage furrow is positioned. ..
  22. Human Sensory Irritation From Volitile Organic Compounds
    William Cain; Fiscal Year: 2006
    ..F) The effect of inflammation upon chemesthetic sensitivity. G) Through measurement of the NMP, confirmation of the peripheral basis for a) temporal phenomena, b) differences in potency, and c) effects of inflammation. ..
  23. MICROTUBULE DYNAMICS AND MITOTIC MECHANISM
    Timothy Mitchison; Fiscal Year: 2007
    ..These discoveries will have immediate relevance to the development of novel cancer drugs. ..
  24. Biochemistry and Cytology of Cytokinesis
    Timothy Mitchison; Fiscal Year: 2006
    ..We will probe how the microtubules associated with cytokinesis are organized in the cell and what mechanisms they use to target anillin and myosin II to the center of the cell to build a furrow there. ..
  25. GENETIC AND BIOCHEMICAL ANALYSIS OF CYTOKINESIS
    Timothy Mitchison; Fiscal Year: 2000
    ....