synephrine

Summary

Summary: Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.

Top Publications

  1. ncbi Determination of octopamine, synephrine and tyramine in Citrus herbs by ionic liquid improved 'green' chromatography
    Fei Tang
    State Key Laboratory of Chemo Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
    J Chromatogr A 1125:182-8. 2006
  2. ncbi High-performance liquid chromatography methods for the analysis of adrenergic amines and flavanones in Citrus aurantium L. var. amara
    Federica Pellati
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Via G Campi 183 411 00 Modena, Italy
    Phytochem Anal 15:220-5. 2004
  3. ncbi Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update
    S Haaz
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Obes Rev 7:79-88. 2006
  4. pmc A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine
    Sidney J Stohs
    Creighton University Medical Center, Omaha, NE 68078, USA
    Int J Med Sci 9:527-38. 2012
  5. pmc Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes
    Sidney J Stohs
    Dean Emeritus, Creighton University Health Sciences Center, Omaha, NE 68178, USA
    Int J Med Sci 8:295-301. 2011
  6. ncbi Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine
    Nicole C Bouchard
    NYC Poison Control Center, New York, NY, USA
    Mayo Clin Proc 80:541-5. 2005
  7. ncbi Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium
    Josep Mercader
    INSERM U1048, Universite de Toulouse, UPS, Institut de Médecine, Moléculaire de Rangueil, Toulouse, France
    J Physiol Biochem 67:443-52. 2011
  8. ncbi Safety and efficacy of citrus aurantium for weight loss
    Stephen Bent
    Osher Center for Integrative Medicine at the University of California, San Francisco, USA
    Am J Cardiol 94:1359-61. 2004
  9. doi Effects of Citrus aurantium (bitter orange) fruit extracts and p-synephrine on metabolic fluxes in the rat liver
    Jéssica Sereno Peixoto
    Department of Biochemistry, University of Maringa, Avenida Colombo 5790, 87020900 Maringa, Brazil
    Molecules 17:5854-69. 2012
  10. pmc STEMI in a 24-year-old man after use of a synephrine-containing dietary supplement: a case report and review of the literature
    John E Thomas
    Department of Medicine Cardiology, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Tex Heart Inst J 36:586-90. 2009

Research Grants

  1. EXPERIMENTAL MODEL OF NEUROGENIC HYPERTENSION
    PETER JANNETTA; Fiscal Year: 1980
  2. Feeding & Transition to Home for Preterms at Social Risk
    Rosemary C White Traut; Fiscal Year: 2010
  3. Feeding & Transition to Home for Preterms at Social Risk
    Rosemary White Traut; Fiscal Year: 2008
  4. Feeding & Transition to Home for Preterms at Social Risk
    Rosemary White Traut; Fiscal Year: 2007
  5. Feeding & Transition to Home for Preterms at Social Risk
    Rosemary White Traut; Fiscal Year: 2009
  6. Obesity and Mortality
    David Allison; Fiscal Year: 2008
  7. UAB Biostatistics Pre-doctoral Training Program
    Hemant Tiwari; Fiscal Year: 2008
  8. UAB Obesity Training Program
    David Allison; Fiscal Year: 2008
  9. Effects of Intentional Weight Loss on Mortality Rate
    David Allison; Fiscal Year: 2007
  10. Effects of Intentional Weight Loss on Mortality Rate
    David Allison; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications141 found, 100 shown here

  1. ncbi Determination of octopamine, synephrine and tyramine in Citrus herbs by ionic liquid improved 'green' chromatography
    Fei Tang
    State Key Laboratory of Chemo Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
    J Chromatogr A 1125:182-8. 2006
    ..solutions of room temperature ionic liquids (RTILs) were used as 'green' mobile phases to determine octopamine, synephrine and tyramine by liquid chromatography...
  2. ncbi High-performance liquid chromatography methods for the analysis of adrenergic amines and flavanones in Citrus aurantium L. var. amara
    Federica Pellati
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Via G Campi 183 411 00 Modena, Italy
    Phytochem Anal 15:220-5. 2004
    ..was used for the simultaneous separation and determination of naturally occurring adrenergic amines (octopamine, synephrine and tyramine) in fruits and dry extracts of Citrus aurantium L. var...
  3. ncbi Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update
    S Haaz
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Obes Rev 7:79-88. 2006
    ..Another substance, Citrus aurantium, which contains several compounds including synephrine alkaloids, has been suggested as a safe alternative...
  4. pmc A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine
    Sidney J Stohs
    Creighton University Medical Center, Omaha, NE 68078, USA
    Int J Med Sci 9:527-38. 2012
    ..as unpublished human studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine, providing information and an assessment of the safety and efficacy of these widely used products...
  5. pmc Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes
    Sidney J Stohs
    Dean Emeritus, Creighton University Health Sciences Center, Omaha, NE 68178, USA
    Int J Med Sci 8:295-301. 2011
    ..Its primary protoalkaloid is p-synephrine. Most studies involving bitter orange extract and p-synephrine have used products with multiple ingredients...
  6. ncbi Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine
    Nicole C Bouchard
    NYC Poison Control Center, New York, NY, USA
    Mayo Clin Proc 80:541-5. 2005
    ..Many of these contain synephrine, a sympathomimetic amine from the plant Citrus aurantium...
  7. ncbi Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium
    Josep Mercader
    INSERM U1048, Universite de Toulouse, UPS, Institut de Médecine, Moléculaire de Rangueil, Toulouse, France
    J Physiol Biochem 67:443-52. 2011
    ..b>Synephrine, octopamine, tyramine, and other alkaloids have been repeatedly identified and quantified in Citrus members of ..
  8. ncbi Safety and efficacy of citrus aurantium for weight loss
    Stephen Bent
    Osher Center for Integrative Medicine at the University of California, San Francisco, USA
    Am J Cardiol 94:1359-61. 2004
    ....
  9. doi Effects of Citrus aurantium (bitter orange) fruit extracts and p-synephrine on metabolic fluxes in the rat liver
    Jéssica Sereno Peixoto
    Department of Biochemistry, University of Maringa, Avenida Colombo 5790, 87020900 Maringa, Brazil
    Molecules 17:5854-69. 2012
    ..An important fruit component is p-synephrine, which is structurally similar to the adrenergic agents...
  10. pmc STEMI in a 24-year-old man after use of a synephrine-containing dietary supplement: a case report and review of the literature
    John E Thomas
    Department of Medicine Cardiology, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Tex Heart Inst J 36:586-90. 2009
    ..This case of STEMI--associated as it is with the use of a synephrine-containing product by a person without risk factors for coronary artery disease--is to our knowledge the 1st ..
  11. ncbi Antidepressant-like effects of p-synephrine in mouse models of immobility tests
    D K Song
    Department of Pharmacology, College of Medicine, Hallym University, Chunchon, Kangwon Do, South Korea
    Neurosci Lett 214:107-10. 1996
    We studied the effects of p-synephrine on the immobility behaviors and on the spontaneous motor activity in mice...
  12. ncbi A rapid liquid chromatography electrospray ionization mass spectrometry(n) method for evaluation of synephrine in Citrus aurantium L. samples
    Luisa Mattoli
    Chemical and Pharmacological Research Area, Aboca S p A, Aboca 20, Sansepolcro AR, Italy
    J Agric Food Chem 53:9860-6. 2005
    ..the safety of the immature bitter orange fruit and its extracts is a debated argument due to the presence of synephrine, a constituent known as a sympathomimetic agent...
  13. ncbi Determination of synephrine in weight-loss products using high performance liquid chromatography with acidic potassium permanganate chemiluminescence detection
    Teo Slezak
    School of Life and Environmental Sciences, Deakin University, Geelong, Victoria 3217, Australia
    Anal Chim Acta 593:98-102. 2007
    ..for these reactions was 680+/-5 nm and, using flow injection analysis methodology, limits of detection for synephrine, octopamine, tyramine and hordenine were found to be between 1x10(-9) and 1x10(-8) M...
  14. ncbi synephrine, a component of Evodiae Fructus, constricts isolated rat aorta via adrenergic and serotonergic receptors
    Tomoko Hibino
    Tsumura Research Laboratories, Tsumura and Co, Japan
    J Pharmacol Sci 111:73-81. 2009
    We investigated the effects of Evodiae Fructus and synephrine, one of the components of Evodiae Fructus, on blood vessels. We found that Evodiae Fructus (1 x 10(-6) - 3 x 10(-4) g/mL) had constrictive effects on rat aorta...
  15. pmc Activities of octopamine and synephrine stereoisomers on alpha-adrenoceptors
    C M Brown
    Department of Pharmacology, Syntex Research Centre, Riccarton, Edinburgh, Scotland
    Br J Pharmacol 93:417-29. 1988
    1. The activities of the (-)- and (+)-forms of m- and p-octopamine and m- and p-synephrine on alpha 1-adrenoceptors from rat aorta and anococcygeus and alpha 2-adrenoceptors from rabbit saphenous vein were compared with those of ..
  16. ncbi Ventricular fibrillation associated with use of synephrine containing dietary supplement
    Travis A Stephensen
    51 MDOS SGOE, Bldg 777, Unit 2060 APO, AP 96278 2060, Osan Air Force Base, Republic of Korea
    Mil Med 174:1313-9. 2009
    ..experienced an episode of ventricular fibrillation associated with the use of a dietary supplement containing synephrine. Recommendations for both physicians and the military regarding monitoring the use of these substances by active ..
  17. doi Concentrations of p-synephrine in fruits and leaves of Citrus species (Rutaceae) and the acute toxicity testing of Citrus aurantium extract and p-synephrine
    M D Arbo
    Programa de Pós Graduação em Ciências Farmacêuticas, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, Av Ipiranga, 2752, CEP 90610 000, Porto Alegre, RS, Brazil
    Food Chem Toxicol 46:2770-5. 2008
    Dietary supplements containing bitter orange unripe fruit extract/p-synephrine are consumed worldwide for lose weight...
  18. ncbi Metabolic and physiological effects of ingesting extracts of bitter orange, green tea and guarana at rest and during treadmill walking in overweight males
    C Sale
    School of Sport, Exercise and Health Sciences, University of Chichester, College Lane, West Sussex, UK
    Int J Obes (Lond) 30:764-73. 2006
    ....
  19. ncbi Hemodynamic effects of synephrine treatment in portal hypertensive rats
    Y T Huang
    Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan
    Jpn J Pharmacol 85:183-8. 2001
    b>Synephrine, a sympathomimetic alpha1-adrenoceptor agonist, has been shown to induce dose-dependent portal hypotensive effects after acute intravenous infusion...
  20. ncbi Seville (sour) orange juice: synephrine content and cardiovascular effects in normotensive adults
    S R Penzak
    Department of Pharmacy Practice, Mercer University, Southern School of Pharmacy, Atlanta, Georgia 30341-4155, USA
    J Clin Pharmacol 41:1059-63. 2001
    The Seville orange extract Citrus aurantium contains m-synephrine (phenylephrine) and octopamine; it causes cardiac disturbances in animals and is used by humans for weight loss...
  21. pmc Human pharmacology of a performance-enhancing dietary supplement under resting and exercise conditions
    Christine A Haller
    Department of Medicine, Division of Clinical Pharmacology, University of California, San Francisco, San Francisco General Hospital, San Francisco, CA, USA
    Br J Clin Pharmacol 65:833-40. 2008
    ..The effect of exercise on the pharmacokinetics and pharmacodynamics of stimulant herbals is unknown...
  22. ncbi Mass spectrometric determination of the predominant adrenergic protoalkaloids in bitter orange (Citrus aurantium)
    Bryant C Nelson
    Analytical Chemistry Division, Stop 8392, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland 20899 8392, USA
    J Agric Food Chem 55:9769-75. 2007
    The predominant adrenergic protoalkaloid found in the peel and fruit of bitter orange, Citrus aurantium, is synephrine. Synephrine is reputed to have thermogenic properties and is used as a dietary supplement to enhance energy and promote ..
  23. doi Synephrine: from trace concentrations to massive consumption in weight-loss
    Luciana Grazziotin Rossato
    REQUIMTE Laboratório de Toxicologia, Departamento de Ciencias Biologicas, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
    Food Chem Toxicol 49:8-16. 2011
    b>Synephrine is cited as 'the active component' of plants and dietary supplements used in weight loss...
  24. pmc Effect of acute administration of an herbal preparation on blood pressure and heart rate in humans
    John G Seifert
    Movement Science Human Performance Laboratory, Montana State University, Bozeman, MT, USA
    Int J Med Sci 8:192-7. 2011
    ..The primary protoalkaloidal ingredient in bitter orange extract is p-synephrine which has some structural similarities to ephedrine and nor-epinephrine, but exhibits markedly different ..
  25. ncbi Coronary spasm and thrombosis in a bodybuilder using a nutritional supplement containing synephrine, octopamine, tyramine and caffeine
    J P Smedema
    S Afr Med J 98:372-3. 2008
  26. ncbi Enantioselective LC analysis of synephrine in natural products on a protein-based chiral stationary phase
    Federica Pellati
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Via G Campi 183, 41100 Modena, Italy
    J Pharm Biomed Anal 37:839-49. 2005
    ..LC method with photodiode array detection (PAD) was developed for the enantioseparation of (+/-)-synephrine from C. aurantium L. var...
  27. ncbi Lipolysis induced by segment wall extract from Satsuma mandarin orange (Citrus unshu Mark)
    Takahiro Tsujita
    Bioscience, Integrated Center for Sciences, Ehime University, Ehime, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:547-51. 2007
    ..High concentration of synephrine, which is an adrenergic amine, was detected in the peel or segment wall extract, whereas it was not detected in ..
  28. doi Subchronic toxicity of Citrus aurantium L. (Rutaceae) extract and p-synephrine in mice
    Marcelo Dutra Arbo
    Laboratório de Análises e Pesquisas Toxicológicas, Departamento de Análises, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, Av Ipiranga, 2752 605, Porto Alegre 90610 000, RS, Brazil
    Regul Toxicol Pharmacol 54:114-7. 2009
    ..Due to the wide use of C. aurantium/p-synephrine-containing products, this research was undertaken to evaluate its subchronic toxicity in mice and their actions ..
  29. doi Effects of synephrine and beta-phenethylamine on human alpha-adrenoceptor subtypes
    Guoyi Ma
    The National Center for Natural Products Research, The University of Mississippi, University, MS 38677, USA
    Planta Med 76:981-6. 2010
    b>Synephrine and beta-phenethylamine, two naturally occurring compounds, are structurally related to ephedrine...
  30. pmc Developmental toxicity of Citrus aurantium in rats
    Deborah K Hansen
    Division of Personalized Nutrition and Medicine, NCTR FDA, Jefferson, Arkansas
    Birth Defects Res B Dev Reprod Toxicol 92:216-23. 2011
    ..The major component in the bitter orange extract is synephrine which is chemically similar to ephedrine...
  31. ncbi Development and validation of a GC/IT-MS method for simultaneous quantitation of para and meta-synephrine in biological samples
    Luciana Grazziotin Rossato
    REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha 164, 4099 030 Porto, Portugal
    J Pharm Biomed Anal 52:721-6. 2010
    ..b>Synephrine, the most abundant active component of C...
  32. ncbi Determination of adrenergic agonists from extracts and herbal products of Citrus aurantium L. var. amara by LC
    Federica Pellati
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Via Campi 183, Modena, Italy
    J Pharm Biomed Anal 29:1113-9. 2002
    The purpose of this study was to set up a HPLC method to separate adrenergic amines (dl-octopamine, dl-synephrine and tyramine) and to determine their content in fruits, extracts and herbal products of Citrus aurantium L. var. amara...
  33. doi Synephrine content of juice from Satsuma mandarins (Citrus unshiu Marcovitch)
    Klaus Dragull
    Western Regional Research Center, Agricultural Research Service, U S Department of Agriculture, 800 Buchanan Street, Albany, California 94710, USA
    J Agric Food Chem 56:8874-8. 2008
    b>Synephrine, the main protoalkaloid in Citrus species, is commonly analyzed as the active component in citrus peel-containing herbal supplements, but the edible parts of mandarins have been largely ignored...
  34. ncbi Citrus aurantium, an ingredient of dietary supplements marketed for weight loss: current status of clinical and basic research
    Adriane Fugh-Berman
    Department of Physiology and Biophysics, Georgetown University, Box 571460, Washington, District of Columbia 20057 1460, USA
    Exp Biol Med (Maywood) 229:698-704. 2004
    ..aurantium may also have the potential to cause adverse health effects. C. aurantium contains synephrine (oxedrine), which is structurally similar to epinephrine...
  35. ncbi An isotopically labeled internal standard liquid chromatography-tandem mass spectrometry method for determination of ephedrine alkaloids and synephrine in dietary supplements
    Martha L Gay
    Center for Food Safety and Applied Nutrition, U S Food and Drug Administration College Park, Maryland 20740, USA
    J Agric Food Chem 54:285-91. 2006
    We report a simplified analytical procedure for determination of ephedrine alkaloids and synephrine in dietary supplements...
  36. ncbi Determination of Bitter Orange alkaloids in dietary supplements standard reference materials by liquid chromatography with ultraviolet absorbance and fluorescence detection
    Karsten Putzbach
    Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    J Chromatogr A 1156:304-11. 2007
    Four adrenergic amines [synephrine, octopamine, tyramine, and n-methyltyramine] were determined in a variety of Bitter Orange containing dietary supplements...
  37. ncbi Development and validation of HPLC methods for the analysis of phenethylamine and indoloquinazoline alkaloids in Evodia species
    Federica Pellati
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    J Sep Sci 29:641-9. 2006
    ..a PEG stationary phase, in comparison with those of C18 columns, for the HPLC analysis of phenethylamine ((+/-)-synephrine) and indoloquinazoline (rutaecarpine and evodiamine) alkaloids in methanolic extracts of fruits of Evodia ..
  38. ncbi A rapid and simple procedure for the determination of synephrine in dietary supplements by gas chromatography-mass spectrometry
    Emilia Marchei
    Drug Control and Evaluation Department, Istituto Superiore di Sanita, V le Regina Elena 299, 00161, Rome, Italy
    J Pharm Biomed Anal 41:1468-72. 2006
    ..and rapid procedure based on gas chromatography-mass spectrometry (GC-MS) is described for determination of synephrine, active principle of Citrus aurantium plant, in solid and liquid dietary supplements...
  39. ncbi Chemiluminescence of synephrine based on the cerium(IV)-rhodamine B system
    Ruifen Wang
    College of Chemistry and Chemical Engineering, Institute of Analytical Sciences, Key Laboratory of Eco environments in Three Gorges Reservoir Region Ministry of Education, Southwest University, Beibei, Chongqing 400715, People s Republic of China
    Luminescence 22:140-6. 2007
    A new chemiluminescence (CL) method is described for the determination of synephrine. It is based on the reaction between synephrine and Ce(IV) in a nitric acid medium and measurement of the CL intensity produced by rhodamine B used as a ..
  40. ncbi A new method for fabrication of an integrated indium tin oxide electrode on electrophoresis microchips with amperometric detection and its application for determination of synephrine and hesperidin in pericarpium citri reticulatae
    Wei Wang
    Key Laboratory of Analysis and Detection Technology for Food Safety, Ministry of Education, Fuzhou University, Fuzhou, Fujian, China
    Electrophoresis 27:4174-81. 2006
    ..On this microchip, a new method was established to separate and determine synephrine and hesperidin, which are the main electroactively bioactive ingredients of pericarpium citri reticulatae, by AD...
  41. ncbi Citrus aurantium--beware of the bitter orange
    Vernon J Louw
    S Afr Med J 98:496. 2008
  42. pmc Determination of synephrine in bitter orange raw materials, extracts, and dietary supplements by liquid chromatography with ultraviolet detection: single-laboratory validation
    Mark C Roman
    ChromaDex, 13161 56th Ct, Suite 201, Clearwater, FL 33760, USA
    J AOAC Int 90:68-81. 2007
    A method has been developed to quantify synephrine in bitter orange raw material, extracts, and dietary supplements...
  43. ncbi Biochemistry of neuromodulation in primary headaches: focus on anomalies of tyrosine metabolism
    G P Nordera
    Headache Center, Neurology Clinic Villa Margherita, Via Costacolonna 6, I 36057 Arcugnano, Italy
    Neurol Sci 28:S94-6. 2007
    Recent studies have suggested that abnormalities of dopamine and trace amines (tyramine, octopamine, and synephrine), products of tyrosine metabolism, may constitute the metabolic events that predispose to the occurrence of cluster ..
  44. ncbi Rational method development strategies on a fluorinated liquid chromatography stationary phase: mobile phase ion concentration and temperature effects on the separation of ephedrine alkaloids
    David S Bell
    Department of Chemistry, The Pennsylvania State University, University Park, 16802, USA
    J Chromatogr A 1095:113-8. 2005
    ..of a fluorinated phase are exploited to rapidly develop separation conditions for ephedrine alkaloids and synephrine using a mobile phase compatible with mass spectrometry...
  45. ncbi Quantitative and qualitative analysis of flavonoid markers in Frucus aurantii of different geographical origin by capillary electrophoresis with electrochemical detection
    Youyuan Peng
    Department of Chemistry, Quanzhou Normal University, Quanzhou 362000, China
    J Chromatogr B Analyt Technol Biomed Life Sci 830:224-30. 2006
    ..detection (CE-ED) method was developed for the simultaneous determination of four major flavonoid markers (synephrine, naringin, hesperidin and naringenin) in Frucus aurantii of different geographical origin...
  46. ncbi Ephedra-free is not danger-free
    Donald M Marcus
    Science 301:1669-71; author reply 1669-71. 2003
  47. ncbi Elevated levels of circulating trace amines in primary headaches
    G D'Andrea
    Headache and Comorbidity Center, Department of Clinical Pathology, Este Monselice Hospital, PD, Italy
    Neurology 62:1701-5. 2004
    Trace amines, including tyramine, octopamine, and synephrine, are closely related to classic biogenic amines...
  48. ncbi Products containing bitter orange or synephrine: suspected cardiovascular adverse reactions
    Scott Jordan
    Health Canada
    CMAJ 171:993-4. 2004
  49. ncbi Molecular mechanisms of toxicity of important food-borne phytotoxins
    Ivonne M C M Rietjens
    Division of Toxicology, Wageningen University, Wageningen, The Netherlands
    Mol Nutr Food Res 49:131-58. 2005
    ..beta-carotene, coumarin, the alkenylbenzenes safrole, methyleugenol and estragole, ephedrine alkaloids and synephrine, kavalactones, anisatin, St...
  50. ncbi Elusive amines and primary headaches: historical background and prospectives
    G D'Andrea
    Headache and Comorbidity Center, Department of Clinical Pathology, Este and Monselice Hospital Via San Fermo 10, I 35042 Este PD, Italy
    Neurol Sci 24:S65-7. 2003
    Although the role of trace amines such as tyramine, octopamine and synephrine in the pathogenesis of migraine has been debated for decades, this issue remains still unresolved...
  51. ncbi The presence of trace amines in postmortem cerebrospinal fluid in humans
    Tiziana Balbi
    Pathological Anatomy, Via Marconi 19, 35045 Monselice, Italy
    J Forensic Sci 50:630-2. 2005
    ..Thus, the occurrence of octopamine, synephrine and tyramine were evaluated by using a HPLC system in 20 postmortem samples of cerebrospinal fluid (obtained ..
  52. ncbi [Determination of three chemical components in Fructus aurantii immaturus]
    Zhen Li Liu
    Institute of Basic Theory of Chinese Medicine, China Academy of Traditional Chinese Medicine, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 31:1425-7. 2006
    ..To determine the contents of 3 kinds of components in Fructus aurantii immaturus...
  53. ncbi [Determination of synephrine and N-methyltyramine in Pericarpium Citri Reticulatae viride by HPLC]
    Xian duan Li
    Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 29:537-9. 2004
    To establish a quantitative method for determination of synephrine and N-methyltyramine in Citri Reticulatae.
  54. ncbi Variant angina associated with bitter orange in a dietary supplement
    Christopher A Gange
    Division of Cardiology, Tufts New England Medical Center, Boston, MA, USA
    Mayo Clin Proc 81:545-8. 2006
    ..To our knowledge, this report describes the first case of variant angina associated with bitter orange in a dietary supplement...
  55. ncbi Determination of hesperidin and synephrine in Pericarpium Citri Reticulatae by capillary electrophoresis with electrochemical detection
    Gang Chen
    Department of Chemistry, Fudan University, Shanghai 200433, P R China
    Anal Bioanal Chem 373:169-73. 2002
    ..with electrochemical detection (CE-ED) has been developed for the determination of hesperidin (HP) and synephrine (SP) in the Chinese traditional herbal drug, Pericarpium Citri Reticulatae, the dried rind of the ripe fruits of ..
  56. ncbi Metal content of ephedra-containing dietary supplements and select botanicals
    Anne A Grippo
    Department of Chemistry and Physics, Arkansas State University, PO Box 599, State University, AR 72467, USA
    Am J Health Syst Pharm 63:635-44. 2006
    ..The metal content of dietary supplements, including 13 ephedra-containing supplements, was studied...
  57. doi Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids
    Berrin Ozcelik
    Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Gazi University, Ankara, Turkey
    Pharm Biol 49:396-402. 2011
    ..colchicine (tropolone-type), allantoin (imidazolidine-type), trigonelline (pyridine-type) as well as octopamine, synephrine, and capsaicin (exocyclic amine-type); the flavonoid derivatives quercetin, apigenin, genistein, naringin, ..
  58. ncbi Detection and validated quantification of nine herbal phenalkylamines and methcathinone in human blood plasma by LC-MS/MS with electrospray ionization
    Jochen Beyer
    Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, D 66421 Homburg Saar, Germany
    J Mass Spectrom 42:150-60. 2007
    ..pseudoephedrine, norephedrine, norpseudoephedrine, methylephedrine, methylpseudoephedrine, cathinone, mescaline, synephrine (oxedrine), and methcathinone in plasma...
  59. ncbi Analysis of ephedra-free labeled dietary supplements sold in the San Francisco Bay area in 2003
    Jennifer W Tam
    University of California, San Francisco UCSF Medicl Center, San Francisco, CA, USA
    J Herb Pharmacother 6:1-19. 2006
    ..To sample dietary supplements (DS) labeled as ephedra-free to evaluate whether products met their labeling claim...
  60. ncbi Consumption of dietary supplements containing Citrus aurantium (bitter orange)--2004 California Behavioral Risk Factor Surveillance Survey (BRFSS)
    Karl C Klontz
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740 3835, USA
    Ann Pharmacother 40:1747-51. 2006
    ..Extracts of C. aurantium contain synephrine, a sympathomimetic alkaloid.
  61. ncbi Strategies for enantioseparations of catecholamines and structurally related compounds by capillary zone electrophoresis using sulfated beta-cyclodextrins as chiral selectors
    Ching Erh Lin
    Department of Chemistry, National Taiwan University, Taipei, Taiwan
    Electrophoresis 27:3443-51. 2006
    ..DL-epinephrine, and DL-isoproterenol) and three structurally related compounds (DL-octopamine, DL-synephrine, and DL-norephedrine) by CZE using sulfated beta-CDs as chiral selectors were investigated...
  62. ncbi Influence of an aziridine precursor on the in vitro binding parameters of rat and ovine corticosteroid-binding globulin (CBG)
    A Louw
    Department of Biochemistry, University of Stellenbosch, Republic of South Africa
    Biochem Pharmacol 59:167-75. 2000
    ..2 nM, 722 microM, and > 1,000,000 microM for cortisol, corticosterone, progesterone, Compound I, and synephrine (Compound II), respectively, were found, while in sheep plasma the values were 0.409 nM, 1.78 nM, 5...
  63. ncbi Biological activities of the shrub Salsola tuberculatiformis Botsch.: contraceptive or stress alleviator?
    Pieter Swart
    Department of Biochemistry, University of Stellenbosch, Stellenbosch, South Africa
    Bioessays 25:612-9. 2003
    ..the active fraction, S2, was extremely labile, partial structure determination suggested the presence of synephrine and a highly reactive aziridine...
  64. ncbi The effects of induced hypertension and acute graded compression on impulse propagation in the spinal nerve roots of the pig
    B Lind
    Department of Orthopaedics, University of California, San Diego
    Spine (Phila Pa 1976) 18:1550-5. 1993
    ..The systemic blood pressure was increased by administration of Neo-Synephrine hydrochloride (phenylephrine HCl) (Winthrop Pharmaceuticals, New York, NY) and elevated 40 +/- 5 mm Hg above the ..
  65. doi Study on the racemization of synephrine by off-column chiral high-performance liquid chromatography
    Federica Pellati
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Via G Campi 183, 41100 Modena, Italy
    J Chromatogr A 1217:3503-10. 2010
    In this study, the racemization kinetic parameters of R-(-)-synephrine, the active phenethylamine alkaloid of Citrus aurantium L., were determined by means of an off-column HPLC method...
  66. ncbi Fast high-performance liquid chromatography analysis of phenethylamine alkaloids in Citrus natural products on a pentafluorophenylpropyl stationary phase
    Federica Pellati
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Via G Campi 183, 41100 Modena, Italy
    J Chromatogr A 1165:58-66. 2007
    ..e. (+/-)-octopamine, (+/-)-synephrine, tyramine, N-methyltyramine and hordenine) in Citrus aurantium plant material (fruits and peel), various Citrus ..
  67. ncbi Determination of ephedrine alkaloids in Ephedra natural products using HPLC on a pentafluorophenylpropyl stationary phase
    Federica Pellati
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Via G Campi 183, 41100 Modena, Italy
    J Pharm Biomed Anal 48:254-63. 2008
    ..Furthermore, the developed technique allowed the simultaneous determination of ephedrine alkaloids and synephrine, the main phenethylamine alkaloid of Citrus aurantium, that has replaced Ephedra in dietary supplements used in ..
  68. ncbi Simultaneous quantification of adrenergic amines and flavonoids in C. aurantium, various Citrus species, and dietary supplements by liquid chromatography
    Bharathi Avula
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677, USA
    J AOAC Int 88:1593-606. 2005
    ..Elution was run at a flow rate of 1.0 mL/min and UV at 254, 280, and 330 nm. Among the amines analyzed, synephrine, the main component, was present in the levels from 0.11 to 2.0 mg/g dry weight in 21 Citrus species and 0...
  69. doi Determination of Citrus aurantium protoalkaloids using HPLC with acidic potassium permanganate chemiluminescence detection
    Dane W Percy
    School of Life and Environmental Sciences, Deakin University, Geelong, Victoria 3217, Australia
    Talanta 80:2191-5. 2010
    ..The products contained a wide concentration range of synephrine and total adrenergic amines, and the difference in consumer intake was even greater when the manufacturers' ..
  70. ncbi Influence of microemulsion chirality on chromatographic figures of merit in EKC: results with novel three-chiral-component microemulsions and comparison with one- and two-chiral-component microemulsions
    Kimberly A Kahle
    Department of Chemistry, Drexel University, Philadelphia, PA 19104, USA
    Electrophoresis 28:3024-40. 2007
    ..pairs of pharmaceutical enantiomers (atenolol, ephedrine, metoprolol, N-methyl ephedrine, pseudoephedrine, and synephrine)...
  71. doi Investigation of polar stationary phases for the separation of sympathomimetic drugs with nano-liquid chromatography in hydrophilic interaction liquid chromatography mode
    Zeineb Aturki
    Istituto di Metodologie Chimiche, Consiglio Nazionale delle Ricerche, Via Salaria km 29 300, Area della Ricerca di Roma 1, Monterotondo Scalo 00015, Rome, Italy
    Anal Chim Acta 685:103-10. 2011
    ..Six sympathomimetic drugs including ephedrine, norephedrine, synephrine, epinephrine, norepinephrine and norphenylephrine were separated by changing experimental parameters such as ..
  72. pmc Trace amine-associated receptor 1-Family archetype or iconoclast?
    David K Grandy
    Department of Physiology and Pharmacology, L334, School of Medicine, Oregon Health and Science University, Portland, OR 97239, United States
    Pharmacol Ther 116:355-90. 2007
    ..on receptors activated by the "trace amines" (TA) beta-phenylethylamine (PEA), tyramine (TYR), octopamine (OCT), synephrine (SYN), and tryptamine (TRYP) is the direct result of 2 publications that appeared in 2001 describing the cloning ..
  73. ncbi Two-chiral component microemulsion EKC - chiral surfactant and chiral oil. Part 2: diethyl tartrate
    Kimberly A Kahle
    Department of Chemistry, Drexel University, Philadelphia, PA 19104, USA
    Electrophoresis 28:2644-57. 2007
    ..of six chiral pharmaceutical compounds: pseudoephedrine, ephedrine, N-methyl ephedrine, metoprolol, synephrine, and atenolol. Average efficiencies increased with the addition of a chiral oil to R-DDCV PSP formulations...
  74. ncbi Characterization of antidepressant-like effects of p-synephrine stereoisomers
    K W Kim
    Department of Pharmacology, Chonbuk National University Medical School, Institute for Medical Sciences, Chonchu, South Korea
    Naunyn Schmiedebergs Arch Pharmacol 364:21-6. 2001
    We previously reported that p-synephrine has antidepressant-like activity in the murine models of forced swimming and tail suspension...
  75. ncbi Electrical storm: case series and review of management
    Uma N Srivatsa
    Department of Cardiology, West Los Angeles VA Medical Center and Department of Cardiology, Olive View Medical Center, Sylmar, UCLA School of Medicine, Los Angeles, California 90073, USA
    J Cardiovasc Pharmacol Ther 8:237-46. 2003
    ..The management of electrical storm is discussed, and evolving literature supporting the routine use of intravenous amiodarone and beta-blockers in place of intravenous lidocaine is critically examined...
  76. ncbi Synthesis of lipids in the fat body of Gryllus bimaculatus: age-dependency and regulation by adipokinetic hormone
    M W Lorenz
    Department of Animal Ecology I, University of Bayreuth, Bayreuth, Germany
    Arch Insect Biochem Physiol 47:198-214. 2001
    ..Octopamine causes a dose-dependent inhibition of acetate incorporation whereas synephrine had no such effect...
  77. ncbi Possible association of acute lateral-wall myocardial infarction and bitter orange supplement
    Diane L Nykamp
    Department of Clinical and Administrative Services, School of Pharmacy, Mercer University, Atlanta, GA 30341 4155, USA
    Ann Pharmacother 38:812-6. 2004
    ..To report a possible incidence of acute lateral-wall myocardial infarction (MI) coinciding with the use of a Citrus aurantium L. (bitter orange)-containing dietary supplement in a patient with undetected coronary vascular disease...
  78. doi Gas-phase spectroscopy of synephrine by laser desorption supersonic jet technique
    Shun ichi Ishiuchi
    Chemical Resources Laboratory, Tokyo Institute of Technology, 4259, Yokahama 226 8503, Japan
    J Phys Chem A 115:10363-9. 2011
    In our previous work, we found that synephrine has six conformers in the gas phase, while adrenaline, which is a catecholamine and has the same side chain as synephrine, has been reported to have only two conformers...
  79. pmc A review of the receptor-binding properties of p-synephrine as related to its pharmacological effects
    Sidney J Stohs
    School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178, USA
    Oxid Med Cell Longev 2011:482973. 2011
    Bitter orange (Citrus aurantium) extract and its primary protoalkaloid p-synephrine are used widely in weight loss/weight management and sports performance products...
  80. ncbi Sensitive determination of norepinephrine, synephrine, and isoproterenol by capillary electrophoresis with indirect electrochemiluminescence detection
    Yan Ming Liu
    College of Chemistry and Chemical Engineering, Xinyang Normal University, Xinyang, PR China
    J Sep Sci 31:2463-9. 2008
    A new and sensitive method for the determination of norepinephrine (NE), synephrine, and isoproterenol was developed by CE separation and indirect electrochemiluminescence detection (ECL) based on their quenching effects on the tris(2,2'-..
  81. doi Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Eur J Pharmacol 600:45-9. 2008
    ..chemopreventive citrus phytochemicals, such as auraptene, nobiletin, citral, citronellal, limonene, limonin, and synephrine were examined...
  82. ncbi Reactions of amino alcohols in superacid: the direct observation of dicationic intermediates and their application in synthesis
    D A Klumpp
    Department of Chemistry, California State Polytechnic University, 3801 West Temple Avenue, Pomona, California 91768, USA
    Org Lett 3:2781-4. 2001
    ..species have been directly observed by low-temperature 13C NMR, including those from epinephrine (adrenaline) and synephrine. Amino alcohols react (70-99% yields) with C6H6 in triflic acid (CF3SO3H) by electrophilic aromatic substitution.
  83. doi Certification of standard reference materials containing bitter orange
    L C Sander
    National Institute of Standards and Technology, Chemical Science and Technology Laboratory, 100 Bureau Drive, MS 8392, Gaithersburg, MD 20899 8392, USA
    Anal Bioanal Chem 391:2023-34. 2008
    ..b>Synephrine, octopamine, tyramine, N-methyltyramine, hordenine, total alkaloids, and caffeine were determined by as many as ..
  84. ncbi Determination of bitter orange alkaloids in dietary supplement Standard Reference Materials by liquid chromatography with atmospheric-pressure ionization mass spectrometry
    Karsten Putzbach
    RCC Ltd, Zelgliweg 1, CH 4452, Itingen, Switzerland
    Anal Bioanal Chem 389:197-205. 2007
    ..spectrometry (LC-API-ES-MS) method has been developed for the determination of five bitter orange alkaloids (synephrine, octopamine, n-methyltyramine, tyramine, and hordenine) in bitter orange-containing dietary supplement standard ..
  85. ncbi Acute tubular necrosis associated with chromium picolinate-containing dietary supplement
    Sachin Wani
    BryanLGH Medical Center, Internal Medicine, University of Nebraska Medical Center, Lincoln, 68502, USA
    Ann Pharmacother 40:563-6. 2006
    ..To report a case of acute tubular necrosis associated with the use of a chromium picolinate-containing dietary supplement...
  86. ncbi [Determination of the active constituents in aurantii fructus from Jiangxi province at different harvest time by HPLC]
    Zheng Hong Li
    Key Laboratory of Modern Preparation of TCM of Ministry of Education, Jiangxi College of TCM, Nanchang 330004, China
    Zhong Yao Cai 36:28-31. 2013
    ..To determine the contents of the main active constituents in Aurantii Fructus from Jiangxi at different harvest time and make sure the best harvest time...
  87. doi A novel molecularly imprinted polymer of the specific ionic liquid monomer for selective separation of synephrine from methanol-water media
    Jie Ping Fan
    Key Laboratory of Poyang Lake Ecology and Bio Resource Utilization of Ministry of Education, Nanchang University, Nanchang 330031, China
    Food Chem 141:3578-85. 2013
    ..as functional monomer was prepared via precipitation polymerization, which can be used to selectively separate synephrine (SYN) from methanol-water media...
  88. ncbi Characterization studies and cytotoxicity assays of Pt(II) and Pd(II) dithiocarbamate complexes by means of FT-IR, NMR spectroscopy and mass spectrometry
    V Alverdi
    Department of Inorganic, Metallorganic and Analytical Chemistry, University of Padua, via Loredan 4, 35131 Padua, Italy
    J Inorg Biochem 98:1117-28. 2004
    ..In particular, synephrine and norphenylephrine appear to be bound to the metal atom through the amino nitrogen atom by means of a dative ..
  89. pmc Citrus aurantium and Rhodiola rosea in combination reduce visceral white adipose tissue and increase hypothalamic norepinephrine in a rat model of diet-induced obesity
    Jessica L Verpeut
    Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA
    Nutr Res 33:503-12. 2013
    ..The hypothesis of these studies was that C aurantium (6% synephrine) and R rosea (3% rosavins, 1% salidroside) in combination would improve diet-induced obesity alterations in ..
  90. pmc Synephrine-containing dietary supplement precipitating apical ballooning syndrome in a young female
    Hyemoon Chung
    Division of Cardiology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
    Korean J Intern Med 28:356-60. 2013
    ..Our case accentuates the potential risk of dietary supplements containing synephrine, which is uncontrolled and available to the general public...
  91. doi Conformational analysis of octopamine and synephrine in the gas phase
    Carlos Cabezas
    Grupo de Espectroscopia Molecular GEM, Unidad Asociada CSIC, Edificio Quifima, Laboratorios de Espectroscopia y Bioespectroscopia, Universidad de Valladolid, 47005 Valladolid, Spain
    J Phys Chem A 117:4907-15. 2013
    Four and six conformers of the neurotransmitters octopamine and synephrine, respectively, have been identified in the gas phase using a laser ablation device in combination with a molecular-beam Fourier transform microwave spectrometer ..
  92. doi Cardiovascular toxicity of Citrus aurantium in exercised rats
    Deborah K Hansen
    Division of Systems Biology, Food and Drug Administration FDA NCTR, 3900 NCTR Rd, Jefferson, AR, 72079, USA
    Cardiovasc Toxicol 13:208-19. 2013
    ..A major component of the BO extract is synephrine, a chemical that is structurally similar to ephedrine...
  93. ncbi Hemodynamic effects of ephedra-free weight-loss supplements in humans
    Christine A Haller
    Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California, San Francisco, 94143, USA
    Am J Med 118:998-1003. 2005
    ..dietary supplements containing bitter orange (Citrus aurantium), a botanical source of the adrenergic amines synephrine and octopamine, have quickly emerged on consumer markets to replace banned ephedra products...
  94. doi Phytochemical profile and antioxidant activity of physiological drop of citrus fruits
    Yujing Sun
    Department of Food Science and Nutrition, School of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, PR China
    J Food Sci 78:C37-42. 2013
    ..The highest level of synephrine was found in Ponkan and Weizhang Satsuma...
  95. ncbi Nitrogen metabolism components as a tool to discriminate between organic and conventional citrus fruits
    Paolo Rapisarda
    Istituto Sperimentale per l Agrumicoltura, Corso Savoia 190, 95024 Acireale CT, Italy
    J Agric Food Chem 53:2664-9. 2005
    ..In addition to the classic quality parameters, total nitrogen (N) and synephrine contents in juice and (15)N/(14)N isotope ratio (expressed as delta(15)N per thousand) in proteins of pulp and ..
  96. doi Structural isomerization of synephrine influences its uptake and ensuing glutathione depletion in rat-isolated cardiomyocytes
    Luciana Grazziotin Rossato
    REQUIMTE, Laboratorio de Toxicologia, Departamento de Ciencias Biologicas, Faculdade de Farmacia, Universidade do Porto, Rua Anibal Cunha, 164, 4099 030 Porto, Portugal
    Arch Toxicol 85:929-39. 2011
    b>Synephrine is a natural compound, frequently added to ephedra-free dietary supplements for weight-loss, due to its effects as a nonspecific adrenergic agonist...
  97. doi Rapid simultaneous determination of amines and organic acids in citrus using high-performance liquid chromatography
    Ram M Uckoo
    Vegetable and Fruit Improvement Center, Department of Horticultural Sciences, 1500 Research Parkway Ste A120, Texas A and M University, College Station, TX 77845, USA
    Talanta 83:948-54. 2011
    ..b>Synephrine was the major amine present in Clementine (114 μg mL(-1)) and Marrs sweet orange (85 μg mL(-1))...
  98. ncbi Effects of biogenic amines and adrenergic drugs on oviposition in the cattle tick Boophilus: evidence for octopaminergic innervation of the oviduct
    T F Booth
    Natural Environment Research Council Institute of Virology, Oxford, Great Britain
    Exp Appl Acarol 7:259-66. 1989
    ..In contrast, the alpha-adrenergic agonists apomorphine, synephrine, phentolamine, metaclopromide and chlorpromazine were ineffective...
  99. doi Fast CE analysis of adrenergic amines in different parts of Citrus aurantium fruit and dietary supplements
    Laura Mercolini
    Department of Pharmaceutical Sciences, Laboratory of Pharmaco Toxicological Analysis, University of Bologna, Alma Mater Studiorum, Bologna, Italy
    J Sep Sci 33:2520-7. 2010
    A CE method has been developed for the simultaneous analysis of the adrenergic amines synephrine, octopamine and tyramine in Citrus aurantium (bitter orange) fruit extracts and in dietary supplements...
  100. ncbi Anti-obese action of raspberry ketone
    Chie Morimoto
    Department of Medical Biochemistry, Ehime University School of Medicine, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    Life Sci 77:194-204. 2005
    ..The structure of RK is similar to the structures of capsaicin and synephrine, compounds known to exert anti-obese actions and alter the lipid metabolism...
  101. ncbi Determination of ephedrine alkaloids in dietary supplement standard reference materials
    Lane C Sander
    Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA
    Anal Chem 77:3101-12. 2005
    ..by the National Institute of Standards and Technology (NIST) with certified values for ephedrine alkaloids, synephrine, caffeine, and selected toxic trace elements...

Research Grants54

  1. EXPERIMENTAL MODEL OF NEUROGENIC HYPERTENSION
    PETER JANNETTA; Fiscal Year: 1980
    ..function is tested by plotting the change of pulse rate with the rapid rise in blood pressure induced by neo-synephrine. The reversibility of the changes when the balloon pulsation is discontinued is studied...
  2. Feeding & Transition to Home for Preterms at Social Risk
    Rosemary C White Traut; Fiscal Year: 2010
    ..For example, reducing hospital stays by just three days for the almost 500,000 infants born prematurely could save over two billion dollars annually. ..
  3. Feeding & Transition to Home for Preterms at Social Risk
    Rosemary White Traut; Fiscal Year: 2008
    ..For example, reducing hospital stays by just three days for the almost 500,000 infants born prematurely could save over two billion dollars annually. ..
  4. Feeding & Transition to Home for Preterms at Social Risk
    Rosemary White Traut; Fiscal Year: 2007
    ..For example, reducing hospital stays by just three days for the almost 500,000 infants born prematurely could save over two billion dollars annually. ..
  5. Feeding & Transition to Home for Preterms at Social Risk
    Rosemary White Traut; Fiscal Year: 2009
    ..For example, reducing hospital stays by just three days for the almost 500,000 infants born prematurely could save over two billion dollars annually. ..
  6. Obesity and Mortality
    David Allison; Fiscal Year: 2008
    ..Measuring obesity as body fatness and fat distribution instead of just using BMI should provide a more solid basis for public health and clinical recommendations by focusing on the more relevant variables of body fatness. ..
  7. UAB Biostatistics Pre-doctoral Training Program
    Hemant Tiwari; Fiscal Year: 2008
    ..Applied experience is provided via co-mentorship by UAB's well established NHLBI-funded investigators. (END OF ABSTRACT) ..
  8. UAB Obesity Training Program
    David Allison; Fiscal Year: 2008
    ..Funding is requested for four post-doctoral trainee slots. ..
  9. Effects of Intentional Weight Loss on Mortality Rate
    David Allison; Fiscal Year: 2007
    ..i ..
  10. Effects of Intentional Weight Loss on Mortality Rate
    David Allison; Fiscal Year: 2008
    ..abstract_text> ..
  11. Obesity and Mortality
    David Allison; Fiscal Year: 2007
    ..Measuring obesity as body fatness and fat distribution instead of just using BMI should provide a more solid basis for public health and clinical recommendations by focusing on the more relevant variables of body fatness. ..
  12. Genome-wide Structured Association Testing & Regional Admixture Mapping
    David Allison; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. Center for Nutrient-Gene Interaction in Cancer Prevention
    Stephen Barnes; Fiscal Year: 2007
    ..In addition to the main projects, the Center will organize a competitive Pilot Project/Developmental program for the evaluation of new ideas and methods pertinent to the overall development of the Center. ..
  14. Body Weight, Adiposity, Energetics and Longevity
    David Allison; Fiscal Year: 2007
    ..This 2-day meeting will bring together expert scientists from diverse disciplines to explore unanswered questions about these interactions and to introduce novel thoughts for future research. [unreadable] [unreadable] [unreadable]..
  15. Genome-wide Structured Association Testing & Regional Admixture Mapping
    David Allison; Fiscal Year: 2008
    ..abstract_text> ..
  16. UAB CLINICAL NUTRITION RESEARCH UNIT
    David Allison; Fiscal Year: 2008
    ..Backed by exceptional institutional support and academic infrastructure, we request renewed funding to continue our successful nutrition/obesity research. ..
  17. Body Composition, Energetics, and Longevity
    David B Allison; Fiscal Year: 2010
    ..The proposed research will help provide information to inform that dialogue. ..
  18. Obesity and Mortality
    David Allison; Fiscal Year: 2009
    ..Measuring obesity as body fatness and fat distribution instead of just using BMI should provide a more solid basis for public health and clinical recommendations by focusing on the more relevant variables of body fatness. ..
  19. Design Issues in Obesity RCTs: Building an Evidence Base
    David B Allison; Fiscal Year: 2010
    ..This research should give valuable answers and critical information for more evidence-based decisions about the design, analysis, and interpretation of obesity RCTs. ..
  20. Center for Nutrient-Gene Interaction in Cancer Preventi*
    Stephen Barnes; Fiscal Year: 2008
    ..In addition to the main projects, the Center will organize a competitive Pilot Project/Developmental program for the evaluation of new ideas and methods pertinent to the overall development of the Center. ..
  21. UAB Obesity Training Program
    David Allison; Fiscal Year: 2008
    ..Funding is requested for four post-doctoral trainee slots. ..
  22. Genome-wide Structured Association Testing & Regional Admixture Mapping
    David Allison; Fiscal Year: 2009
    ..abstract_text> ..
  23. Obesity and Mortality
    David Allison; Fiscal Year: 2009
    ..Measuring obesity as body fatness and fat distribution instead of just using BMI should provide a more solid basis for public health and clinical recommendations by focusing on the more relevant variables of body fatness. ..
  24. Design Issues in Obesity RCTs: Building an Evidence Base
    David Allison; Fiscal Year: 2009
    ..This research should give valuable answers and critical information for more evidence-based decisions about the design, analysis, and interpretation of obesity RCTs. ..
  25. UAB Statistical Genetics Post-doctoral Training Program
    David Allison; Fiscal Year: 2008
    ..Strong collaborative ties among the faculty facilitate this approach. ..
  26. Genome-wide Structured Association Testing & Regional Admixture Mapping
    David B Allison; Fiscal Year: 2010
    ..abstract_text> ..
  27. UAB Biostatistics Pre-doctoral Training Program
    David Allison; Fiscal Year: 2007
    ..Applied experience is provided via co-mentorship by UAB's well established NHLBI-funded investigators. (END OF ABSTRACT) ..
  28. UAB Obesity Training Program
    David Allison; Fiscal Year: 2007
    ..Funding is requested for four post-doctoral trainee slots. ..
  29. Design, Analysis, & Interpretation of RCTs in Obesity
    David Allison; Fiscal Year: 2006
    ..The meeting will take place in December of 2006 and be attended by scientists from academia, government, and industry. [unreadable] [unreadable]..
  30. STATISTICAL GENETICS FOR OBESITY & NUTRITION RESEARCHERS
    David Allison; Fiscal Year: 2002
    ..At each course, lectures will be supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. ..
  31. TRANSGENIC MICE FOR STUDYING DRUGS OF ABUSE
    David Grandy; Fiscal Year: 2002
    ....
  32. 9.4 Tesla Fourier Transform Mass Spectrometer
    Stephen Barnes; Fiscal Year: 2002
    ..Overall, the FT-MS instrument will sustain the high quality of biomedical research that is a hallmark of UAB. ..
  33. DOES WEIGHT LOSS REDUCE MORTALITY RATE AMONG OBESE RATS?
    David Allison; Fiscal Year: 2002
    ..This study will, for the first time, allow a rigorous experimental test of the hypothesis that among obese organisms, WL promotes longevity. ..
  34. STATISTICAL GENETICS FOR OBESITY & NUTRITION RESEARCHERS
    David Allison; Fiscal Year: 2001
    ..At each course, lectures will be supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. ..
  35. STATISTICAL GENETICS FOR OBESITY & NUTRITION RESEARCHERS
    David Allison; Fiscal Year: 2000
    ..At each course, lectures will be supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. ..
  36. STATISTICAL GENETICS FOR OBESITY & NUTRITION RESEARCHERS
    David Allison; Fiscal Year: 2001
    ..At each course, lectures will be supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. ..
  37. TRANSGENIC MICE FOR STUDYING DRUGS OF ABUSE
    David Grandy; Fiscal Year: 2001
    ....
  38. DOES WEIGHT LOSS REDUCE MORTALITY RATE AMONG OBESE RATS?
    David Allison; Fiscal Year: 2001
    ..This study will, for the first time, allow a rigorous experimental test of the hypothesis that among obese organisms, WL promotes longevity. ..
  39. TRANSGENIC MICE FOR STUDYING DRUGS OF ABUSE
    David Grandy; Fiscal Year: 2000
    ....
  40. TRANSGENIC MICE FOR STUDYING DRUGS OF ABUSE
    David Grandy; Fiscal Year: 1999
    ....
  41. D4 Receptor-Mediated Effects of Methylphenidate in Mice
    David Grandy; Fiscal Year: 2003
    ..It is our expectation that upon the successful completion of these aims, a better understanding of the complex relationship between MPD exposure, D4R stimulation, gene expression, and rodent behaviors relevant to ADHD will emerge ..
  42. STATISTICAL GENETICS FOR OBESITY & NUTRITION RESEARCHERS
    David Allison; Fiscal Year: 2003
    ..At each course, lectures will be supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. ..
  43. UAB Statistical Genetics Post-doctoral Training Program
    David Allison; Fiscal Year: 2007
    ..Regular reviews of trainees will be completed to insure adequate progress toward an independent research career. ..
  44. D4 Receptor-Mediated Effects of Methylphenidate in Mice
    David Grandy; Fiscal Year: 2007
    ..that upon the successful completion of these aims, a better understanding of the complex relationship between MPD exposure, D4R stimulation, gene expression, and rodent behaviors relevant to ADHD will emerge [unreadable] [unreadable]..
  45. Effects of Intentional Weight Loss on Mortality Rate
    David Allison; Fiscal Year: 2007
    ..abstract_text> ..
  46. AMINO ACID CONJUGATION OF BILE ACIDS
    Stephen Barnes; Fiscal Year: 2006
    ..abstract_text> ..
  47. STATISTICAL GENETICS FOR OBESITY & NUTRITION RESEARCHERS
    David Allison; Fiscal Year: 2005
    ..Lectures are supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. ..
  48. D4 Receptor-Mediated Effects of Methylphenidate in Mice
    David Grandy; Fiscal Year: 2006
    ..that upon the successful completion of these aims, a better understanding of the complex relationship between MPD exposure, D4R stimulation, gene expression, and rodent behaviors relevant to ADHD will emerge [unreadable] [unreadable]..
  49. Effects of Intentional Weight Loss on Mortality Rate
    David Allison; Fiscal Year: 2006
    ..abstract_text> ..
  50. D4 Receptor-Mediated Effects of Methylphenidate in Mice
    David Grandy; Fiscal Year: 2005
    ..It is our expectation that upon the successful completion of these aims, a better understanding of the complex relationship between MPD exposure, D4R stimulation, gene expression, and rodent behaviors relevant to ADHD will emerge ..
  51. STATISTICAL GENETICS FOR OBESITY & NUTRITION RESEARCHERS
    David Allison; Fiscal Year: 2004
    ..At each course, lectures will be supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. ..
  52. A sensitive triple quadrupole mass spectrometer
    Stephen Barnes; Fiscal Year: 2004
    ..It is anticipated that a commercial nanospray interface for use in nanoLC-MS analysis will be available by the fall of 2003. ..
  53. D4 Receptor-Mediated Effects of Methylphenidate in Mice
    David Grandy; Fiscal Year: 2004
    ..It is our expectation that upon the successful completion of these aims, a better understanding of the complex relationship between MPD exposure, D4R stimulation, gene expression, and rodent behaviors relevant to ADHD will emerge ..