polyglycolic acid

Summary

Summary: A biocompatible polymer used as a surgical suture material.

Top Publications

  1. ncbi PLGA-based nanoparticles: an overview of biomedical applications
    Fabienne Danhier
    Universite Catholique de Louvain, Louvain Drug Research Institute, Pharmaceutics and Drug Delivery, Avenue Mounier, B1 73 12, 1200 Brussels, Belgium
    J Control Release 161:505-22. 2012
  2. ncbi Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    Jayanth Panyam
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Adv Drug Deliv Rev 55:329-47. 2003
  3. ncbi Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration
    Yin Meng Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
    Int J Pharm 416:331-8. 2011
  4. pmc Programming the magnitude and persistence of antibody responses with innate immunity
    Sudhir Pai Kasturi
    Emory Vaccine Center, Emory University, Atlanta, Georgia 30329, USA
    Nature 470:543-7. 2011
  5. ncbi The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices
    R A Jain
    NanoSystems, a Division of Elan Pharmaceutical Technologies, King of Prussia, PA 19406, USA
    Biomaterials 21:2475-90. 2000
  6. pmc Current advances in research and clinical applications of PLGA-based nanotechnology
    Jian ming Lu
    Michael E DeBakey Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Expert Rev Mol Diagn 9:325-41. 2009
  7. ncbi Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype
    Stacey L Demento
    Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA
    Biomaterials 33:4957-64. 2012
  8. ncbi The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems--a review
    Susanne Fredenberg
    Department of Chemical Engineering, Lund University, PO Box 124, SE 221 00 Lund, Sweden
    Int J Pharm 415:34-52. 2011
  9. ncbi Characterization of nanoparticle uptake by endothelial cells
    Jasmine Davda
    Department of Pharmaceutical Sciences, College of Pharmacy, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
    Int J Pharm 233:51-9. 2002
  10. ncbi Chondrogenic differentiation of human adipose-derived stem cells in polyglycolic acid mesh scaffolds under dynamic culture conditions
    Nastaran Mahmoudifar
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
    Biomaterials 31:3858-67. 2010

Detail Information

Publications394 found, 100 shown here

  1. ncbi PLGA-based nanoparticles: an overview of biomedical applications
    Fabienne Danhier
    Universite Catholique de Louvain, Louvain Drug Research Institute, Pharmaceutics and Drug Delivery, Avenue Mounier, B1 73 12, 1200 Brussels, Belgium
    J Control Release 161:505-22. 2012
    ..This review focuses on the understanding of specific characteristics exploited by PLGA-based nanoparticles to target a specific organ or tissue or specific cells...
  2. ncbi Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    Jayanth Panyam
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Adv Drug Deliv Rev 55:329-47. 2003
    ..Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed...
  3. ncbi Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration
    Yin Meng Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
    Int J Pharm 416:331-8. 2011
    ..These findings provide further understanding for the possible therapeutic effects of curcumin and C-NPs in further pre-clinical and clinical research...
  4. pmc Programming the magnitude and persistence of antibody responses with innate immunity
    Sudhir Pai Kasturi
    Emory Vaccine Center, Emory University, Atlanta, Georgia 30329, USA
    Nature 470:543-7. 2011
    ..Immunization protected completely against lethal avian and swine influenza virus strains in mice, and induced robust immunity against pandemic H1N1 influenza in rhesus macaques...
  5. ncbi The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices
    R A Jain
    NanoSystems, a Division of Elan Pharmaceutical Technologies, King of Prussia, PA 19406, USA
    Biomaterials 21:2475-90. 2000
    ..Also, certain issues about other related biodegradable polyesters are discussed...
  6. pmc Current advances in research and clinical applications of PLGA-based nanotechnology
    Jian ming Lu
    Michael E DeBakey Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Expert Rev Mol Diagn 9:325-41. 2009
    ....
  7. ncbi Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype
    Stacey L Demento
    Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA
    Biomaterials 33:4957-64. 2012
    ..Thus, this study highlights the importance of sustained antigen release mediated by particulate platforms and its role in the long-term appearance of effector memory cellular response...
  8. ncbi The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems--a review
    Susanne Fredenberg
    Department of Chemical Engineering, Lund University, PO Box 124, SE 221 00 Lund, Sweden
    Int J Pharm 415:34-52. 2011
    ..Basic, generally applicable and mechanistic research provides pieces of the puzzle, which is useful in the development of controlled-release pharmaceuticals...
  9. ncbi Characterization of nanoparticle uptake by endothelial cells
    Jasmine Davda
    Department of Pharmaceutical Sciences, College of Pharmacy, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
    Int J Pharm 233:51-9. 2002
    ..Nanoparticles localized in the endothelium could provide prolonged drug effects because of their sustained release characterics, and also could protect the encapsulated agent from enzymatic degradation...
  10. ncbi Chondrogenic differentiation of human adipose-derived stem cells in polyglycolic acid mesh scaffolds under dynamic culture conditions
    Nastaran Mahmoudifar
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
    Biomaterials 31:3858-67. 2010
    ..Cells cultured under dynamic conditions in polyglycolic acid (PGA) scaffolds produced substantially higher glycosaminoglycan (GAG) and total collagen levels than cells ..
  11. ncbi CD8- dendritic cells and macrophages cross-present poly(D,L-lactate-co-glycolate) acid microsphere-encapsulated antigen in vivo
    Christopher Schliehe
    Division of Immunology, Department of Biology, Constance University, 78457 Konstanz, Germany
    J Immunol 187:2112-21. 2011
    ..Moreover, immune responses in BATF3 knockout mice lacking CD8(+) DCs were normal. The results presented in this work strongly suggest that in vivo cross-priming of PLGA MS-encapsulated Ag is performed by CD8(-) DCs and MΦs...
  12. ncbi Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake
    Sanjeeb K Sahoo
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center 986025, Omaha, NE 68198 6025, USA
    J Control Release 82:105-14. 2002
    ..In conclusion, the residual PVA associated with nanoparticles is an important formulation parameter that can be used to modulate the pharmaceutical properties of PLGA nanoparticles...
  13. ncbi Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with paclitaxel
    Fabienne Danhier
    Universite Catholique de Louvain, Unite de Pharmacie Galenique, Avenue Mounier 73 20, 1200 Brussels, Belgium
    J Control Release 140:166-73. 2009
    ..Hence, the targeting of anti-cancer drug to tumor endothelium by RGD-labeled NP is a promising approach...
  14. pmc Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo
    Preetha Anand
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX 77030, USA
    Biochem Pharmacol 79:330-8. 2010
    ..Overall we demonstrate that curcumin-loaded PLGA nanoparticles formulation has enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo over curcumin...
  15. ncbi PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect
    Sarbari Acharya
    Institute of Life Sciences, Nalco Square, Bhubaneswar, India
    Adv Drug Deliv Rev 63:170-83. 2011
    ..Ongoing research about drug-loaded nanoparticles and their delivery by the EPR effect to the tumour tissues has been elucidated in this review with clarity...
  16. ncbi Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation
    Fabienne Danhier
    Universite Catholique de Louvain, Unite de Pharmacie Galenique, Avenue Mounier, 73 20, 1200 Brussels, Belgium
    J Control Release 133:11-7. 2009
    ..Therefore, PTX-loaded nanoparticles may be considered as an effective anticancer drug delivery system for cancer chemotherapy...
  17. pmc Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform
    Che Ming J Hu
    Department of Nanoengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:10980-5. 2011
    ..The translocation of natural cellular membranes, their associated proteins, and the corresponding functionalities to the surface of synthetic particles represents a unique approach in nanoparticle functionalization...
  18. pmc Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome
    Fiona A Sharp
    Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 106:870-5. 2009
    ..Our data demonstrate that uptake of microparticulate adjuvants by DCs activates the NALP3 inflammasome, and this contributes to their enhancing effects on innate and antigen-specific cellular immunity...
  19. ncbi Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells
    Murali Mohan Yallapu
    Cancer Biology Research Center, Sanford Research USD, Sioux Falls, SD 57105, USA
    J Colloid Interface Sci 351:19-29. 2010
    ....
  20. ncbi Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery
    Jayanth Panyam
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    FASEB J 16:1217-26. 2002
    ..S. Food and Drug Administration. Hence PLGA is well suited for sustained intracellular delivery of macromolecules...
  21. ncbi Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody
    Petra Kocbek
    University of Ljubljana, Faculty of Pharmacy, Askerceva 7, Ljubljana, Slovenia
    J Control Release 120:18-26. 2007
    ..Furthermore, the results show the effectiveness of the new carrier system for targeted delivery of small or large active substances into cells or tissues of interest...
  22. ncbi Polymer degradation and in vitro release of a model protein from poly(D,L-lactide-co-glycolide) nano- and microparticles
    Jayanth Panyam
    Department of Pharmaceutical Sciences, 986025 University of Nebraska Medical Center, Omaha, NE 68198 6025, USA
    J Control Release 92:173-87. 2003
    ..1 microm) as compared to the larger-size microparticles could explain some of the observed degradation results with different size particles...
  23. ncbi Adipose-derived adult stromal cells heal critical-size mouse calvarial defects
    Catherine M Cowan
    The Department of Surgery, Stanford University School of Medicine, Stanford University, 257 Campus Drive, Stanford, California 94305, USA
    Nat Biotechnol 22:560-7. 2004
    ..The contribution of implanted cells to new bone formation was 84-99% by chromosomal detection. These data show that ADAS cells heal critical-size skeletal defects without genetic manipulation or the addition of exogenous growth factors...
  24. pmc Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents
    R Dinarvand
    Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Int J Nanomedicine 6:877-95. 2011
    ....
  25. ncbi Stabilization and encapsulation of recombinant human erythropoietin into PLGA microspheres using human serum albumin as a stabilizer
    Jintian He
    Hebei Normal University, Hebei Province, People s Republic of China he
    Int J Pharm 416:69-76. 2011
    ..The results suggested that the integrity of rhEPO was successfully protected during the encapsulation process and the release period from polymeric matrices...
  26. pmc PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses
    Wenxue Ma
    Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA
    Int J Nanomedicine 7:1475-87. 2012
    ..These results demonstrate that the delivery of peptides encapsulated in PLGA-NPs is a promising approach to induce effective antitumor CTL responses in vivo...
  27. ncbi Characterization of polylactic acid-polyglycolic acid composites for cartilage tissue engineering
    John M Moran
    Center for Tissue Engineering, University of Massachusetts Medical School, Worcester, Massachusetts 01655 0300, USA
    Tissue Eng 9:63-70. 2003
    ..on the physical properties, adhesion, and growth of bovine articular chondrocytes on polylactic acid (PLA)/polyglycolic acid (PGA) composites...
  28. ncbi Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs
    Khin Yin Win
    Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    Biomaterials 26:2713-22. 2005
    ..It is highly feasible for nanoparticles of biodegradable polymers to be applied to promote oral chemotherapy...
  29. ncbi Effect of acidic pH on PLGA microsphere degradation and release
    Banu S Zolnik
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, United States
    J Control Release 122:338-44. 2007
    ..4. This is the first time that morphological changes during PLGA microsphere degradation have been compared for low and neutral pH and the data shows a change in the mechanism of degradation at the low pH...
  30. ncbi Development of biodegradable nanoparticles for oral delivery of ellagic acid and evaluation of their antioxidant efficacy against cyclosporine A-induced nephrotoxicity in rats
    K Sonaje
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research NIPER, SAS Nagar, Mohali, Punjab, 160062, India
    Pharm Res 24:899-908. 2007
    ..Ellagic acid (EA), a dietary antioxidant associated with poor biopharmaceutical properties, was encapsulated into poly(lactide-co-glycolide) (PLGA) and polycaprolactone (PCL) nanoparticles to improve oral bioavailability...
  31. ncbi Preparation and characterization of a polymeric (PLGA) nanoparticulate drug delivery system with simultaneous incorporation of chemotherapeutic and thermo-optical agents
    Romila Manchanda
    Department of Biomedical Engineering, Florida International University, 10555 West Flagler Street, Miami, FL 33174, USA
    Colloids Surf B Biointerfaces 75:260-7. 2010
    ..022+/-0.001%, w/w, for DOX (n=3). The release pattern was biphasic. ICG and DOX loaded-nanoparticle preparation was standardized based on the following parameters: PLGA concentration, PVA concentration and initial drug content...
  32. ncbi Preparation and characterization of cationic PLGA nanospheres as DNA carriers
    M N V Ravi Kumar
    Department of Biopharmaceutics and Pharmaceutical Technology, Saarland University, D 66123, Saarbrucken, Germany
    Biomaterials 25:1771-7. 2004
    ..These cationic PLGA nanospheres could serve as potential alternatives of the existing negatively charged nanoparticles...
  33. ncbi PLA/PLGA nanoparticles for sustained release of docetaxel
    T Musumeci
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Catania, Viale A Doria 6, I 95125 Catania, Italy
    Int J Pharm 325:172-9. 2006
    ..Kinetic experiments demonstrated that the release process of DTX form nanospheres is affected by the molecular weight of the employed polymers...
  34. pmc Retention of in vitro and in vivo BMP-2 bioactivities in sustained delivery vehicles for bone tissue engineering
    Diederik H R Kempen
    Tissue Engineering and Biomaterials Laboratory, Department of Orthopedic Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Biomaterials 29:3245-52. 2008
    ..Overall, the results from this study show that BMP-2 could be incorporated into various bone tissue engineering composites for sustained release over a prolonged period of time with retention of bioactivity...
  35. ncbi Characterization of poly(D,L-lactic-co-glycolic acid) based nanoparticulate system for enhanced delivery of antigens to dendritic cells
    Praveen Elamanchili
    Faculty of Pharmacy and Pharmaceutical Sciences, 3118 Dentistry Pharmacy Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Vaccine 22:2406-12. 2004
    ..These results strongly suggest that PLGA nanoparticles provide an efficient vaccine delivery system for targeting DCs and the development of DC based cellular vaccines...
  36. pmc Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers
    Frank Gu
    Department of Chemical Engineering, Harvard MIT Center of Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:2586-91. 2008
    ..This approach may contribute to further development of targeted NPs as highly selective and effective therapeutic modalities...
  37. ncbi Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives
    Raghavendra C Mundargi
    Industrial Biotechnology Group, Reliance Life Sciences Pvt Ltd, Dhirubhai Ambani Life Sciences Centre, Thane Belapur Road, Rabale, Navi Mumbai 400 701, India
    J Control Release 125:193-209. 2008
    ..The present review attempts to address some important data on nano/microparticle-based delivery systems of PLGA and PLGA-derived polymers with reference to macromolecular drugs...
  38. ncbi Design of estradiol loaded PLGA nanoparticulate formulations: a potential oral delivery system for hormone therapy
    S Hariharan
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar, 160062, Punjab, India
    Pharm Res 23:184-95. 2006
    ..Histopathological examination and blood counts indicated the absence of inflammatory response. These data suggest that DMAB stabilized PLGA nanoparticles have great potential as carriers for oral delivery of estradiol...
  39. ncbi Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides
    Noha Nafee
    Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbrucken, Germany
    Nanomedicine 3:173-83. 2007
    ..The study proved the efficacy of chitosan-coated PLGA nanoparticles as a flexible and efficient delivery system for antisense oligonucleotides to lung cancer cells...
  40. ncbi Enhanced mucosal and systemic immune response with intranasal immunization of mice with HIV peptides entrapped in PLG microparticles in combination with Ulex Europaeus-I lectin as M cell target
    Monika Manocha
    Department of Biochemistry, All India Institute of Medical Sciences AIIMS, Ansari Nagar, New Delhi 110029, India
    Vaccine 23:5599-617. 2005
    ..Thus, overall the study highlighted the combination of UEA-1 lectin with HIV peptides in micro-particles through intranasal immunization generated systemic as well as mucosal immune response...
  41. ncbi In vitro degradation of three-dimensional porous poly(D,L-lactide-co-glycolide) scaffolds for tissue engineering
    Linbo Wu
    Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, No 220, Handan Road, Shanghai 200433, China
    Biomaterials 25:5821-30. 2004
    ....
  42. ncbi PLGA nanoparticles in drug delivery: the state of the art
    Indu Bala
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research NIPER, Punjab, India
    Crit Rev Ther Drug Carrier Syst 21:387-422. 2004
    ..Careful design of these delivery systems with respect to target and route of administration may solve some of the problems faced by new classes of active molecules...
  43. ncbi Targeted epidermal growth factor receptor nanoparticle bioconjugates for breast cancer therapy
    Sarbari Acharya
    Institute of Life Sciences, Nalco Square, Chandrasekharpur, Bhubaneswar, Orissa, India
    Biomaterials 30:5737-50. 2009
    ..Thus it was concluded that EGFR-Rapa-NPs provide an efficient and targeted delivery of anticancer drugs, presenting a promising active targeting carrier for tumor selective therapeutic treatment in near future...
  44. pmc The uptake and intracellular fate of PLGA nanoparticles in epithelial cells
    Malgorzata S Cartiera
    Department of Biomedical Engineering, Yale University, 55 Prospect Street, MEC 414, New Haven, CT 06520 8260, USA
    Biomaterials 30:2790-8. 2009
    ..We present a model for the intracellular fate of particles that is consistent with our experimental data...
  45. ncbi The effect of poloxamer 188 on nanoparticle morphology, size, cancer cell uptake, and cytotoxicity
    Fei Yan
    The Shenzhen Key Laboratory of Gene and Antibody Therapy, Center for Biotech and Bio Medicine and Division of Life Sciences, Graduate School at Shenzhen, Tsinghua University, Shenzhen, People s Republic of China
    Nanomedicine 6:170-8. 2010
    ....
  46. pmc Physiologically based pharmacokinetic modeling of PLGA nanoparticles with varied mPEG content
    Mingguang Li
    Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48202, USA
    Int J Nanomedicine 7:1345-56. 2012
    ..Further, the predicted biodistribution profiles of PLGA-mPEG495 were close to experimental data, reflecting properly developed property-biodistribution relationships...
  47. pmc Potent engineered PLGA nanoparticles by virtue of exceptionally high chemotherapeutic loadings
    Elizabeth M Enlow
    Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Nano Lett 11:808-13. 2011
    ..Particles with 40% loading display better in vitro efficacy than particles with lower loadings and the clinical formulation of docetaxel, Taxotere...
  48. ncbi Preparation and characterization of PLGA microspheres by the electrospraying method for delivering simvastatin for bone regeneration
    Subrata Deb Nath
    Department of Biomedical Engineering and Materials, Soonchunhyang University, Asan, South Korea
    Int J Pharm 443:87-94. 2013
    ..Thus, electrosprayed PLGA microspheres have potential as a drug delivery system and application in bone tissue engineering...
  49. pmc Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy
    Stacey L Demento
    Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA
    Vaccine 27:3013-21. 2009
    ..The design of such an antigen delivery mechanism with the ability to stimulate two potent innate immune pathways represents a potent new approach to simultaneous antigen and adjuvant delivery...
  50. ncbi The uptake of PLGA micro or nanoparticles by macrophages provokes distinct in vitro inflammatory response
    Roberto Nicolete
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, 14040 903, Ribeirao Preto, Sao Paulo, Brazil
    Int Immunopharmacol 11:1557-63. 2011
    ....
  51. ncbi The development and mechanism studies of cationic chitosan-modified biodegradable PLGA nanoparticles for efficient siRNA drug delivery
    Xudong Yuan
    Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy, Long Island University, 75 DeKalb Avenue, Brooklyn, New York 11201 5497, USA
    Pharm Res 27:1285-95. 2010
    ....
  52. ncbi Encapsulation of protein drugs in biodegradable microparticles by co-axial electrospray
    Jingwei Xie
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117576 Singapore
    J Colloid Interface Sci 317:469-76. 2008
    ..Therefore, co-axial electrospray could be a very promising approach to encapsulate biomacromolecules such as proteins, enzymes, DNA plasmids or living cells inside microparticles for controlled release drug delivery applications...
  53. pmc Polyglycolic acid-induced inflammation: role of hydrolysis and resulting complement activation
    Kathleen Ceonzo
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Tissue Eng 12:301-8. 2006
    ..Various scaffolds are currently used, whereas polyglycolic acid (PGA), which is currently used in absorbable sutures and orthopedic pins, provides an excellent support for ..
  54. ncbi Biocompatibility and integrin-mediated adhesion of human osteoblasts to poly(DL-lactide-co-glycolide) copolymers
    Rosanna Di Toro
    Department of Pharmacology, University of Bologna, Irnerio 48, 40126, Bologna, Italy
    Eur J Pharm Sci 21:161-9. 2004
    The biocompatibility of polylactic acid (PLA) and polyglycolic acid (PGA) copolymers, employed in manufacturing bone-graft substitutes, is affected by their chemical composition, molecular weight and cell environment, and by the methods ..
  55. ncbi Antibody targeting of camptothecin-loaded PLGA nanoparticles to tumor cells
    Paul A McCarron
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, U K
    Bioconjug Chem 19:1561-9. 2008
    ....
  56. ncbi AS1411 aptamer tagged PLGA-lecithin-PEG nanoparticles for tumor cell targeting and drug delivery
    Athulya Aravind
    Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University Kawagoe, Saitama, Japan
    Biotechnol Bioeng 109:2920-31. 2012
    ..The results confirmed that AS1411 aptamer-PLGA-lecithin-PEG NPs are potential carrier candidates for differential targeted drug delivery...
  57. pmc Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery
    Qiaobing Xu
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachussets Avenue, Cambridge, MA 02139, USA
    Small 5:1575-81. 2009
    ..These results demonstrate the utility of microfluidic FF for the generation of homogenous systems of particles for the delivery of drugs...
  58. ncbi PLGA/TPGS nanoparticles for controlled release of paclitaxel: effects of the emulsifier and drug loading ratio
    Li Mu
    Division of Bioengineering, The National University of Singapore, 9 Engineering Drive 1, Singapore 117576
    Pharm Res 20:1864-72. 2003
    ..Among various controlling parameters in the process, the present work is to elucidate the effects of the surfactant stabilizer and the drug loading ratio...
  59. ncbi Biodegradable block copolymers for delivery of proteins and water-insoluble drugs
    G M Zentner
    MacroMed Inc, 9520 South State Street, Sandy, UT 84070, USA
    J Control Release 72:203-15. 2001
    ..Efficacies equivalent to maximum tolerated systemic dosing were observed at OncoGel doses that were 10-fold lower. Data on protein release (pGH, G-CSF, insulin, rHbsAg) and polymer biocompatibility are discussed...
  60. ncbi Novel polymer-DNA hybrid polymeric micelles composed of hydrophobic poly(D,L-lactic-co-glycolic acid) and hydrophilic oligonucleotides
    J H Jeong
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejon 305-701, South Korea
    Bioconjug Chem 12:917-23. 2001
    ..Compared to unconjugated ODN, the ODN/PLGA micelles could be more efficiently transported within cells, presumably by endocytosis. This study proposes a potential delivery method of ODN into cells by forming hybrid ODN/PLGA micelles...
  61. ncbi Enhanced electrostatic interaction between chitosan-modified PLGA nanoparticle and tumor
    Rui Yang
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151 742, Republic of Korea
    Int J Pharm 371:142-7. 2009
    ....
  62. ncbi The support of neural stem cells transplanted into stroke-induced brain cavities by PLGA particles
    Ellen Bible
    Kings College London, Institute of Psychiatry, Department of Neuroscience, London SE5 9NU, UK
    Biomaterials 30:2985-94. 2009
    ..These neuro-scaffolds could therefore be a more advanced method to enhance brain repair. This study provides a substantial step in the technology development required for the translation of this approach...
  63. ncbi Accelerating thrombolysis with chitosan-coated plasminogen activators encapsulated in poly-(lactide-co-glycolide) (PLGA) nanoparticles
    Tze Wen Chung
    Department of Chemical Engineering, National Yunlin University of Science and Technology, Tou Liu, Yunlin, Taiwan, ROC
    Biomaterials 29:228-37. 2008
    ..In conclusion, the NPs designed based on new concepts significantly accelerate thrombolysis in vitro in this model, and may be useful in clinical study...
  64. ncbi Nanoformulation of D-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide) diblock copolymer for breast cancer therapy
    LaiQiang Huang
    School of Life Sciences, Tsinghua University, Beijing 100084, PR China
    Integr Biol (Camb) 3:993-1002. 2011
    ..In conclusion, the TPGS-b-(PCL-ran-PGA) copolymer could be acted as a novel and potential biologically active polymeric material for nanoformulation in breast cancer chemotherapy...
  65. ncbi Poly(lactide)-vitamin E derivative/montmorillonite nanoparticle formulations for the oral delivery of Docetaxel
    Si Shen Feng
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biomaterials 30:3297-306. 2009
    ..59% for Taxotere((R)) to 78% for the PLA-TPGS/MMT NP formulation and 91% for the PLA-TPGS NP formulation respectively. Oral chemotherapy by nanoparticles of biodegradable polymers is feasible...
  66. ncbi Dynamics of endocytosis and exocytosis of poly(D,L-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells
    Jayanth Panyam
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198 6025, USA
    Pharm Res 20:212-20. 2003
    ..The purpose of this work was to characterize the process of endocytosis, exocytosis, and intracellular retention of poly (D,L-lactide-co-glycolide) nanoparticles in vitro using human arterial vascular smooth muscle cells (VSMCs)...
  67. ncbi Factors affecting the loading efficiency of water-soluble drugs in PLGA microspheres
    Fuminori Ito
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan
    Colloids Surf B Biointerfaces 61:25-9. 2008
    ..That is, when the diameter of the primary emulsion is much smaller than that of the secondary emulsion, PLGA microspheres with high-loading efficiency of blue dextran were obtained...
  68. ncbi Experimental study on the regeneration of peripheral nerve gaps through a polyglycolic acid-collagen (PGA-collagen) tube
    Tasuo Nakamura
    Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Brain Res 1027:18-29. 2004
    We have developed a bioabsorbable polyglycolic acid (PGA) tube filled with collagen sponge (PGA-collagen tube) as a nerve connective guide, and compared its effectiveness with that of autograft in terms of nerve regeneration across a gap...
  69. ncbi A multiplexed electrospray process for single-step synthesis of stabilized polymer particles for drug delivery
    Begoña Almería
    Department of Mechanical Engineering and Materials Science, Yale University, New Haven, CT 06520 8286, USA
    J Control Release 154:203-10. 2011
    ..Our study highlights the importance of tight control over particle size and morphology and the avoidance of particle aggregation for control over the release kinetics and formulation repeatability...
  70. ncbi Paclitaxel loaded folic acid targeted nanoparticles of mixed lipid-shell and polymer-core: in vitro and in vivo evaluation
    Peiqi Zhao
    The Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
    Eur J Pharm Biopharm 81:248-56. 2012
    ..Our data indicate that PTX loaded FLPNPs are a promising nano-sized drug formulation for cancer therapy...
  71. ncbi Establishing chitosan coated PLGA nanosphere platform loaded with wide variety of nucleic acid by complexation with cationic compound for gene delivery
    Kohei Tahara
    Laboratory of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University, 1 100, Kusumoto, Chikusa, Nagoya, Aichi 464 8650, Japan
    Int J Pharm 354:210-6. 2008
    ..Chitosan coated PLGA nanosphere platform was established to encapsulate satisfactorily wide variety of nucleic acid for an acceptable gene delivery system...
  72. ncbi The influence of structural design of PLGA/collagen hybrid scaffolds in cartilage tissue engineering
    Wenda Dai
    Biomaterials Center, National Institute for Materials Science, 1 1 Namiki, Tsukuba, Ibaraki 305 0044, Japan
    Biomaterials 31:2141-52. 2010
    ..These scaffolds could be used for the tissue engineering of articular cartilage with adjustable thickness. The design of the hybrid structures provides a strategy for the preparation of 3D porous scaffolds...
  73. pmc Antigen-displaying lipid-enveloped PLGA nanoparticles as delivery agents for a Plasmodium vivax malaria vaccine
    James J Moon
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 7:e31472. 2012
    ..vivax sporozoites. These results demonstrate that these VMP001-NPs are promising vaccines candidates that may elicit protective immunity against P. vivax sporozoites...
  74. ncbi Preparation and immunological effectiveness of a Swine influenza DNA vaccine encapsulated in PLGA microspheres
    Kai Zhao
    Laboratory of Microbiology, College of Life Science, Heilongjiang University, Harbin, PR China
    J Microencapsul 27:178-86. 2010
    ..These results have laid a foundation for further development before ultimate industrial application...
  75. ncbi Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery
    Carrie S W Chong
    Faculty of Pharmacy and Pharmaceutical Sciences, Dentistry Pharmacy Building, University of Alberta, 3118 Edmonton, Alberta, Canada T6G 2N8
    J Control Release 102:85-99. 2005
    ..These findings suggest that appropriate design of the vaccine formulation and careful planning of the immunization schedule are important in the successful development of effective HBV therapeutic vaccines...
  76. ncbi Biodegradable nanoparticle delivery of a Th2-biased peptide for induction of Th1 immune responses
    M E Christine Lutsiak
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    J Pharm Pharmacol 58:739-47. 2006
    ..The ability of PLGA nanoparticles to alter the type of immune response elicited by a peptide, even in the context of an ongoing immune response, makes PLGA nanoparticles a strong candidate for the formulation of therapeutic vaccines...
  77. ncbi Micro and nano-scale in vitro 3D culture system for cardiac stem cells
    Hossein Hosseinkhani
    International Research Institute for Integrated Medical Sciences IREIIMS, Tokyo Women s Medical University, Tokyo 162 8666, Japan
    J Biomed Mater Res A 94:1-8. 2010
    ..The use of micro- and nano-scale materials in the fabrication of composites together with a 3D culture system is a very promising way to promote the culture of stem cells. (c) 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010...
  78. pmc Decreased lung carcinoma cell density on select polymer nanometer surface features for lung replacement therapies
    Lijuan Zhang
    Department of Chemistry, Brown University, Providence, RI 02912, USA
    Int J Nanomedicine 5:269-75. 2010
    ..In this manner, PLGA with specific nanometer surface features may inhibit lung cancer cell density which may provide an important biomaterial for the treatment of lung cancer (from drug delivery to regenerative medicine)...
  79. ncbi Interaction of biodegradable nanoparticles with intestinal cells: the effect of surface hydrophilicity
    Marie Gaumet
    Department of Pharmaceutics and Biopharmaceutics, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 30, quai E Ansermet, CH 1211 Geneva 4, Switzerland
    Int J Pharm 390:45-52. 2010
    ..The location of particles <300 nm appeared to be intracellular and some particles colocalized with the nucleus...
  80. ncbi Preparation and evaluation of lectin-conjugated PLGA nanoparticles for oral delivery of thymopentin
    Yashu Yin
    Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, China
    J Control Release 116:337-45. 2006
    ..These results confirmed that the conjugation of WGA onto PLGA nanoparticles effectively improved the intestinal absorption of TP5 due to specific bioadhesion on GI cell membrane...
  81. pmc Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines
    Anil Mahapatro
    Bioengineering Program and Department of Industrial and Manufacturing Engineering, Wichita State University, 1845 Fairmount Street, Wichita, KS 67260, USA
    J Nanobiotechnology 9:55. 2011
    ....
  82. ncbi Lectin-conjugated PLGA nanoparticles loaded with thymopentin: ex vivo bioadhesion and in vivo biodistribution
    Yashu Yin
    Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, China
    J Control Release 123:27-38. 2007
    ..These results further revealed the promising potential of lectin-conjugated nanoparticles on the improvement of intestinal bioadhesion and absorption for oral drug delivery...
  83. ncbi Development of novel self-assembled DS-PLGA hybrid nanoparticles for improving oral bioavailability of vincristine sulfate by P-gp inhibition
    Guixia Ling
    School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China
    J Control Release 148:241-8. 2010
    ..The new DPNs might provide an effective strategy for oral delivery of VCR with improved encapsulation efficiency and oral bioavailability...
  84. pmc Polymeric nanoparticles for siRNA delivery and gene silencing
    Yogesh Patil
    Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
    Int J Pharm 367:195-203. 2009
    ..Serum stability and lack of cytotoxicity further add to the potential of PLGA-PEI nanoparticles in gene silencing-based therapeutic applications...
  85. ncbi Design of biodegradable nanoparticles for oral delivery of doxorubicin: in vivo pharmacokinetics and toxicity studies in rats
    D R Kalaria
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar, 160 062, Punjab, India
    Pharm Res 26:492-501. 2009
    ..Doxorubicin, a potent anticancer drug associated with cardiotoxicity and low oral bioavailability, was loaded into nanoparticles with a view to improve its performance...
  86. pmc Design of curcumin loaded cellulose nanoparticles for prostate cancer
    Murali Mohan Yallapu
    Cancer Biology Research Center, Sanford Research University of South Dakota, Sioux Falls, SD 57104 0589, USA
    Curr Drug Metab 13:120-8. 2012
    ..Our study shows, for the first time, the feasibility of cellulose-CUR formulation and its potential use in prostate cancer therapy...
  87. ncbi Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells
    Kohei Tahara
    Laboratory of Pharmaceutical Engineering, School of Pharmaceutical Science, Aichi Gakuin University, 1 100, Kusumoto, Chikusa, Nagoya, Aichi 464 8650, Japan
    Int J Pharm 382:198-204. 2009
    ..CS-PLGA NSs were taken up by A549 cells in an energy-dependent manner, suggesting a clathrin-mediated endocytic process. CS-PLGA NS demonstrated low cytotoxicity, similar to non-PLGA NS...
  88. ncbi Quantitative assessment of scaffold and growth factor-mediated repair of critically sized bone defects
    Megan E Oest
    Orthopaedic Research Laboratory, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, IBB Room 2311, 315 Ferst Drive NW, Atlanta, Georgia 30332, USA
    J Orthop Res 25:941-50. 2007
    ..However, functional integration of the constructs appeared limited by continued presence of slow-degrading scaffolds and suboptimal dose or delivery of osteoinductive signals...
  89. ncbi Intracellular trafficking of nuclear localization signal conjugated nanoparticles for cancer therapy
    Ranjita Misra
    Institute of Life Sciences, Nalco Square, Chandrasekharpur, Bhubaneswar, Orissa, India
    Eur J Pharm Sci 39:152-63. 2010
    ..In conclusion, these results suggested that NLS conjugated doxorubicin loaded NPs could be potentially useful as novel drug delivery system for breast cancer therapy...
  90. ncbi Preparation and properties of poly(lactide-co-glycolide) (PLGA)/ nano-hydroxyapatite (NHA) scaffolds by thermally induced phase separation and rabbit MSCs culture on scaffolds
    Y X Huang
    Institute of Nano and Bio Polymeric Materials, Tongji University, Shanghai 200092, PR China
    J Biomater Appl 22:409-32. 2008
    ..NHA. The results suggest that the newly developed PLGA/NHA composite scaffolds may serve as an excellent 3D substrate for cell attachment and migration in bone tissue engineering...
  91. ncbi Targeting the central nervous system: in vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123
    G Tosi
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    J Control Release 122:1-9. 2007
    ..The ability to enter the CNS appears to be linked to the sequence of the peptidic moiety present on their surface...
  92. ncbi Co-delivery of cancer-associated antigen and Toll-like receptor 4 ligand in PLGA nanoparticles induces potent CD8+ T cell-mediated anti-tumor immunity
    Samar Hamdy
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2N8, Canada
    Vaccine 26:5046-57. 2008
    ..These results support the potential use of PLGA nanoparticles as competent carriers for future cancer vaccine formulations...
  93. ncbi Solid-state solubility influences encapsulation and release of hydrophobic drugs from PLGA/PLA nanoparticles
    Jayanth Panyam
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 986025, Omaha, Nebraska 68198, USA
    J Pharm Sci 93:1804-14. 2004
    ..In conclusion, the solid-state drug-polymer solubility affects the nanoparticle characteristics, and thus could be used as an important preformulation parameter...
  94. ncbi Evaluation of tissue-engineered vascular autografts
    Goki Matsumura
    Cardiovascular Surgery, Heart Institute of Japan, Tokyo Women s Medical University, Tokyo, Japan
    Tissue Eng 12:3075-83. 2006
    ..These results indicate that TEVAs are a biocompatible material with functional endothelial cells and biomechanical properties and do not have unwanted side effects...
  95. ncbi Formation of nanoparticles of a hydrophilic drug using supercritical carbon dioxide and microencapsulation for sustained release
    Amol J Thote
    Department of Chemical Engineering, Auburn University, Auburn, Alabama 36849 5127, USA
    Nanomedicine 1:85-90. 2005
    ....
  96. ncbi Preparation of nanoparticles composed of poly(gamma-glutamic acid)-poly(lactide) block copolymers and evaluation of their uptake by HepG2 cells
    Hsiang Fa Liang
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC
    J Control Release 105:213-25. 2005
    ..The aforementioned results indicated that the galactosylated nanoparticles prepared in the study had a specific interaction with HepG2 cells via ligand-receptor recognition...
  97. ncbi Porous poly(alpha-hydroxyacid)/Bioglass composite scaffolds for bone tissue engineering. I: Preparation and in vitro characterisation
    V Maquet
    Centre for Education and Research on Macromolecules, University of Liege, Belgium
    Biomaterials 25:4185-94. 2004
    ..Formation of hydroxyapatite on the surface of composites, as an indication of their bioactivity, was recorded by EDXA, X-ray diffractometry and confirmed by Raman spectroscopy...
  98. ncbi PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination
    Marie Garinot
    Universite Catholique de Louvain, Unite de Pharmacie Galenique, Brussels, Belgium
    J Control Release 120:195-204. 2007
    ..Finally, ovalbumin-loaded nanoparticles were orally administrated to mice and induced an IgG response, attesting antigen ability to elicit an immune response after oral delivery...
  99. ncbi Chemical degradation of peptides and proteins in PLGA: a review of reactions and mechanisms
    M L Houchin
    Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas, USA
    J Pharm Sci 97:2395-404. 2008
    ..This review summarizes the peptide/protein chemical degradation reactions that have been reported in PLGA systems and their mechanisms. Reported methods for stabilizing peptides and proteins in PLGA devices are also discussed...
  100. ncbi Folate-receptor-targeted delivery of docetaxel nanoparticles prepared by PLGA-PEG-folate conjugate
    Farnaz Esmaeili
    Novel Drug Delivery Systems Laboratory, Faculty of Pharmacy, Medical Sciences, University of Tehran, Tehran, Iran
    J Drug Target 16:415-23. 2008
    ..These results suggested that FOL-targeted DTX NPs could be a potentially useful delivery system for FOL-receptor-positive cancer cells...
  101. ncbi Controlled release of sirolimus from a multilayered PLGA stent matrix
    Xintong Wang
    School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore
    Biomaterials 27:5588-95. 2006
    ..The release of sirolimus can, on the other hand, be retarded by using a coating of a biodegradable polyester with a lauryl ester end group. Therefore, multilayered systems offer many options for controlling sirolimus release over months...

Research Grants59

  1. Engineered Cartilage Storage and Transport Solution
    Kelvin Brockbank; Fiscal Year: 2005
    ..TECCS will be manufactured using polyglycolic acid felt and human chondrocytes...
  2. A COMPARISON OF IN VIVO AND VITRO TISSUE ENGINEERING
    Bradley Kropp; Fiscal Year: 2004
    ..cell cultures from the host's native bladder and has shown promise for use with membranes fabricated from polyglycolic acid polymers (PAP)...
  3. VITRIFICATION FOR TISSUE ENGINEERED BLOOD VESSELS
    Ying Song; Fiscal Year: 2005
    ..ice-free cryopreservation, known as vitrification, can have a salutary effects on the cryopreservation of polyglycolic acid - derived engineered vessels containing smooth muscle cells which otherwise sustain significant injury from ..
  4. CELL-POLYMER IMPLANT USING A RODENT BETA-CELL LINE
    Shelley Weinstock; Fiscal Year: 1993
    ..HIT-or RIN-cells will be seeded on available biodegradable, biocompatible polyglycolic acid or co-polymer of polylactic and polyglycolic acids...
  5. TISSUE ENGINEERING OF PULMONARY VALVES AND PULMONARY ART
    John Mayer; Fiscal Year: 2002
    ..The TE structures created using polyglycolic acid polymer have poor surgical handling characteristics...
  6. Functionally Graded Scaffolds for Tissue Engineering
    Suman Das; Fiscal Year: 2004
    ..will be fabricated using a selective laser sintering machine with powder materials including polylactic acid-polyglycolic acid copolymers (PLGA), and PLGA-Hydroxyapatite (HA) composites with different volume fractions of HA in the PLGA ..
  7. BIODEGRADABLE RELEASE NANOPARTICLES FOR RESTENOSIS
    Vinod Labhasetwar; Fiscal Year: 2000
    ..Polylactic/polyglycolic acid copolymers and polycaprolactones will be used to form 100nm diameter of nanoparticles...
  8. SITE-SPECIFIC GENE THERAPY FOR MYOCARDIAL ANGIOGENESIS
    Weiliam Chen; Fiscal Year: 2001
    ..the applicant proposes to: encapsulate DNA in small nanometer diameter particles with a poly-lactic-polyglycolic acid co-polymer, assess the in vitro delivery mechanism of nanoparticles using beta -galactosidase as a model ..
  9. Helical Rosette Nanotubes for Treating Osteoporotic Bone
    Thomas Webster; Fiscal Year: 2008
    ..abstract_text> ..
  10. Chemoprevention of Oral Dysplasia by Black Raspberries
    Susan Mallery; Fiscal Year: 2005
    ..This experimental design (comparison of pretreatment and post-treatments tissues) permits each patient to serve as their own internal control. ..
  11. Role of Oxidants & Angiogenesis in Kaposi's Sarcoma
    Susan Mallery; Fiscal Year: 2007
    ..Elucidation of these interactions will not only clarify KS pathogenic mechanisms, but will also identify sites for KS therapeutic intervention. ..
  12. Formulation & Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention
    Susan Mallery; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  13. Nano Fibers for ADME/Toxicology
    Peter Ma; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  14. Orchestrating Bone Regeneration on Multiple Scales
    Peter X Ma; Fiscal Year: 2010
    ..SA 3. Confirm that the multi-scaled and factor-releasing scaffolds (selected from Aims 1&2) afford a superior environment for vascularized bone regeneration in a rat critical defect model. ..
  15. Biomimetic Nano Scaffolds
    Peter Ma; Fiscal Year: 2004
    ..This knowledge will enable us to develop a predictable biomimetic scaffold for in vivo application and will be the basis for our planned R01 investigation. ..
  16. Gene Therapy for Musculoskeletal Repair
    Cato Laurencin; Fiscal Year: 2004
    ..abstract_text> ..
  17. VASCULARIZATION IN TISSUE ENGINEERED CONSTRUCTS
    Charles Patrick; Fiscal Year: 2001
    ..does TEC-recipient inosculation play in TEC vascularization? (b) What are the biological functions of CD144, principally with regards to its role in inosculation and its regulation by the unique TEC microenvironment? ..
  18. Adrenal Cortical Cell Therapy
    James Dunn; Fiscal Year: 2008
    ..These studies will lead to a better understanding of the development of the adrenal cortex, as well as a new therapy that replaces the physiological function of the adrenal cortex. ..
  19. CONSTRUCTING NEUROTROPHIN FIELDS IN THE BRAIN
    W Saltzman; Fiscal Year: 2002
    ..abstract_text> ..
  20. Composition/Functional Elasticity of Engineered Tissues
    SEAN KOHLES; Fiscal Year: 2003
    ..The results will be used to predict the time-dependent performance of cell-polymer constructs, and to gain insight into the mechanisms of scaffold degradation and ECM synthesis...
  21. Towards the development of a "living" cochlear implant
    Xuejun Wen; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. MOLECULAR AND CELLULAR TRANSPORT IN MUCUS
    W Saltzman; Fiscal Year: 2001
    ..Finally, these polymeric systems will be used to test the efficacy of delivery for sustained protection against unwanted pregnancy (immunocontraception). ..
  23. MOLECULAR AND CELLULAR TRANSPORT IN MUCUS
    W Saltzman; Fiscal Year: 2008
    ..abstract_text> ..
  24. Cellular Cardiomyoplasty in Vitro: Host-Donor Cell Interactions
    Nenad Bursac; Fiscal Year: 2007
    ..The final aim is to aid in the development of efficient and safe cell-based approaches for the treatment of regional heart injury due to ischemia, infarction, or congenital defects. [unreadable] [unreadable] [unreadable]..
  25. Hip Joint Resurfacing with Functional Human Cartilage
    Lisa Freed; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  26. Subharmonic Microbubble Signals for Pressure Estimation
    Flemming Forsberg; Fiscal Year: 2008
    ..This will allow potentially life-threatening diseases, such as increased pressure in the liver, to be diagnosed early. [unreadable] [unreadable] [unreadable]..
  27. Biomimetic Scaffolds for Abdominal Wall Repair
    Anshu Mathur; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  28. Multiaxial Single-Cell Biomechanics for Mechanotransduction
    SEAN KOHLES; Fiscal Year: 2007
    ..contribute to the understanding of pathologic cell states and therapeutic approaches for load-bearing tissues, and guide the design of engineered biomaterials which control cellular function [unreadable] [unreadable] [unreadable]..
  29. Blood Outgrowth Endothelial Cell Seeding of Heart Valve Leaflets
    Robert J Levy; Fiscal Year: 2010
    ..This proposal will investigate a novel approach for a heart valve replacement by studying a trileaflet polyurethane valve that is seeded with autologous blood outgrowth endothelial cells. ..
  30. Semiconductor Nanosensors for Label-Free Detection of Antigens and Cellular Immun
    Mark Reed; Fiscal Year: 2010
    ..These nanosensors can replace current technology with a powerful solid-state device useful for rapid diagnosis in clinical settings. ..
  31. Rational Design of a Cardiac Tissue Engineering Scaffold
    Lisa E Freed; Fiscal Year: 2010
    ..abstract_text> ..
  32. Combined Chemoprevention Using a Nanotechnology-based Therapeutic System
    Sunil Prabhu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. Interdisciplinary Pre-doctoral Training Program in Neuroengineering(RMI)
    W Saltzman; Fiscal Year: 2008
    ..abstract_text> ..
  34. Interdisciplinary Pre-doctoral Training Program in Neuroengineering(RMI)
    W Saltzman; Fiscal Year: 2008
    ..abstract_text> ..
  35. Development and Characterization of a Novel Contrast Agent
    Margaret Wheatley; Fiscal Year: 2009
    ..A diagnostic tool that could safely and non-invasively detect tumors at an early stage, before metastasis, would be a great advance in health care. ..
  36. Novel Biodegradable Materials for Tissue Engineering
    Cato Laurencin; Fiscal Year: 2008
    ..Specific Aim 3: To perform biological evaluation of novel blends of polyphosphazenes with PLAGA using in vivo animal models. ..
  37. CHILDHOOD VACCINES AND DENTAL CARIES IMMUNITY
    Daniel Smith; Fiscal Year: 2007
    ..unreadable]..
  38. Microfluidic/controlled systems on brain microprobes
    W Saltzman; Fiscal Year: 2007
    ..abstract_text> ..
  39. ENHANCED DURABILITY OF BIOPROSTHETIC HEART VALVES
    Michael Sacks; Fiscal Year: 2004
    ..Determine how chemical treatment alters cuspal layer micromechanics. 2. Quantify PBHV cuspal deformation during the cardiac cycle. 3. Determine how long-term cyclic fatigue alters PBHV later structure and mechanical properties. ..
  40. Differential gene expression in the CNS stem cells
    Natalia Abramova; Fiscal Year: 2004
    ..abstract_text> ..
  41. Polyurethane Calcification:Mechanism and Inhibition
    Robert Levy; Fiscal Year: 2004
    ..abstract_text> ..
  42. Rational Design of Peptide-Based Tumor Vaccine
    WILSON MENG; Fiscal Year: 2004
    ..The research proposed will also benefit the development of peptide-based vaccines for viral and microbial infections. ..
  43. Controlled Delivery System for Naltrexone
    EMMANUEL AKALA; Fiscal Year: 2004
    ....
  44. Contrast Enhanced Ultrasound with Therapeutic Modality
    Margaret Wheatley; Fiscal Year: 2004
    ..These studies are a prelude to show feasibility prior to in vivo studies. ..
  45. 3D Adipose Tissue Generation and Functional Verification
    Charles Patrick; Fiscal Year: 2004
    ..abstract_text> ..
  46. CARDIOVASCULAR CALCIFICATION PATHOPHYSIOLOGY & TREATMENT
    Robert Levy; Fiscal Year: 2003
    ....
  47. 8th Conference - Chemistry & Biology Mineralized Tissue
    WILLIAM LANDIS; Fiscal Year: 2004
    ....
  48. Novel Osteoinductive Protein Synthesizing Implant System
    Kyumin Whang; Fiscal Year: 2003
    ....
  49. Contrast-Enhanced Ultrasound Detection of Angiogenesis
    Flemming Forsberg; Fiscal Year: 2004
    ..If successful, this project will permit non-invasive ultrasound evaluations of anti-angiogenic tumor therapies in animals as well as humans. ..
  50. RHESUS MACAQUE MODEL OF TUBERCULOSIS
    DAVID LEWINSOHN; Fiscal Year: 2001
    ..g., CT scans, quantitative culture of mycobacteria from BAL fluids and liver biopsies) which correlate with survival. ..
  51. Development of a Multi-phased Scaffold for Soft Tissue to Bone Integration
    Helen Lu; Fiscal Year: 2006
    ..abstract_text> ..
  52. Micro-and Nano-engineering of Biomineralized Materials
    W Saltzman; Fiscal Year: 2006
    ..Since precisely designed synthetic materials will be produced and characterized to meet the study objectives, this project will also lead to new approaches for engineering of dental and orthopedic tissue. ..
  53. MINERAL-MATRIX RELATIONS IN CALCIFYING TISSUES
    WILLIAM LANDIS; Fiscal Year: 2006
    ....
  54. Efficacy and Safety of Baclofen for Alcohol Dependence
    James Garbutt; Fiscal Year: 2006
    ..Several studies also have found that baclofen reduces self-reported anxiety and craving; thus, the proposed study will assess baclofen's ability to reduce these symptoms as well. ..
  55. Control and Quantitation of Pulmonary Contusion
    Joel Stitzel; Fiscal Year: 2005
    ..It is made possible by combining modern instrumentation and state of the art biomechanical computer codes with basic injury research at the institution performed by clinicians. ..
  56. PROLONGED DURATION LOCAL ANESTHESIA
    DANIEL KOHANE; Fiscal Year: 2004
    ..Finally, we will study the effectiveness of prolonged duration local anesthesia in preventing or mitigating the development of pain-related behaviors and the rise in GAP-43 expression following nerve crush injury. ..
  57. Insulin Producing Cells from Amniotic Stem Cells for Diabetes Therapy
    Anthony Atala; Fiscal Year: 2009
    ..Successful development of an abundant source of transplantable insulin producing cells potentially would have a profound impact on the treatment of a major public health problem. ..
  58. MYOCARDIAL CONTROLLED RELEASE IMPLANTS FOR ARRHYTHMIAS
    Robert Levy; Fiscal Year: 2001
    ..Plasmid DNA delivery will be achieved using sustained release nanoparticles formulated from polylactic-polyglycolic acid (PLGA), with co-incorporated poly-L- lysine(PLL) to enhance DNA delivery...