Summary: Synthetic thermoplastics that are tough, flexible, inert, and resistant to chemicals and electrical current. They are often used as biocompatible materials for prostheses and implants.
Publications198 found, 100 shown here
- The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particlesGerald J Atkins
Discipline of Orthopaedics and Trauma, The University of Adelaide, Adelaide, SA 5005, Australia
Biomaterials 30:3672-81. 2009..Overall, our results suggest that PE particles directly induce a change in the phenotype of mature osteoblasts and osteocytes, consistent with the net loss of bone near orthopaedic implants...
- Contact stress assessment of conventional and highly crosslinked ultra high molecular weight polyethylene acetabular liners with finite element analysis and pressure sensitive filmGordon R Plank
Harris Orthopaedic Biomechanics and Biomaterials Laboratory, Massachusetts General Hospital, 55 Fruit Street, Jackson 1126, Boston, Massachusetts 02114, USA
J Biomed Mater Res B Appl Biomater 80:1-10. 2007..Obviously, other considerations will influence the minimum thickness to be recommended...
- Larger diameter femoral heads used in conjunction with a highly cross-linked ultra-high molecular weight polyethylene: a new conceptO K Muratoglu
Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Arthroplasty 16:24-30. 2001..Even for the 46-mm femoral head, wear was reduced significantly using criteria of gravimetric and geometric measurements and morphologic appearance of the machining marks out to 11 million cycles of simulated gait...
- Charnley wear model for validation of hip simulators--ball diameter versus polytetrafluoroethylene and polyethylene wearI C Clarke
Howard and Irene Peterson Tribology Laboratory, Loma Linda University Medical Center, California, United States of America
Proc Inst Mech Eng H 211:25-36. 1997..These data compared well with the clinical data...
- Crosslinked polyethylene compared to conventional polyethylene in total hip replacement: pre-clinical evaluation, in-vitro testing and prospective clinical follow-up studyCarel H Geerdink
Department of Orthopaedic Surgery, Atrium Medisch Centrum, Heerlen, CX, NL 6401, The Netherlands
Acta Orthop 77:719-25. 2006Polyethylene wear-induced osteolysis is a major cause of implant loosening in total hip arthroplasty. New crosslinked polyethylenes are presumed to give lower wear rates, but no long-term clinical results are available yet.
- Assessment of wear in extensively irradiated UHMWPE cups in simulator studiesHironobu Oonishi
H. Oonishi Memorial Joint Replacement Institute, Tominaga Hospital, 4-48, 1-chome, Minato-Machi, Naniwa-ku, Osaka, 556-0017, Japan
J Biomed Mater Res A 68:52-60. 2004..This indicates that we should take care to ensure that our desire to reduce the wear debris to a zero amount does not result in a modified UHMWPE that lacks the necessary mechanical properties for contemporary metal-backed cup designs...
- The effect of socket design, materials and liner thickness on the wear of the porous coated anatomic total hip replacementA P Elfick
Centre for Biomedical Engineering, School of Engineering, University of Durham, UK
Proc Inst Mech Eng H 215:447-57. 2001..No correlation was found between the thickness of the liner and the clinical wear factor. Within the range of thicknesses tested here, UHMWPE thickness is not an influential parameter for the hip prosthesis and this is confirmed..
- Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal musclesQi Long Lu
Muscle Cell Biology, Medical Research Council Clinical Science Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Proc Natl Acad Sci U S A 102:198-203. 2005..We conclude that a significant therapeutic effect may be achieved by further optimization in dose and regime of administration of antisense oligonucleotide...
- Unified wear model for highly crosslinked ultra-high molecular weight polyethylenes (UHMWPE)O K Muratoglu
Massachusetts General Hospital, Orthopaedic Biomechanics Laboratory, Boston 02114, USA
Biomaterials 20:1463-70. 1999....
- Bulk and dispersed aqueous phase behavior of phytantriol: effect of vitamin E acetate and F127 polymer on liquid crystal nanostructureYao-Da Dong
Department of Pharmaceutics, Victoria College of Pharmacy, Monash University, Parkville, Victoria 3052, Australia
Langmuir 22:9512-8. 2006..Taken together, these results indicate that phytantriol may not only provide an alternative lipid for preparation of liquid crystalline systems in excess water but may also provide access to properties not available when using GMO...
- Surface analysis of early retrieved acetabular polyethylene liners: a comparison of conventional and highly crosslinked polyethylenesOrhun K Muratoglu
Harvard Medical School, Department of Orthopaedic Surgery, Boston, Massachusetts, USA
J Arthroplasty 19:68-77. 2004..These observations support the hypothesis that the early in vivo scratching of highly cross-linked polyethylene acetabular liners is primarily caused by plastic deformation...
- Dissemination of wear particles to the liver, spleen, and abdominal lymph nodes of patients with hip or knee replacementR M Urban
Department of Orthopedic Surgery, The Rush Arthritis and Orthopedic Institute, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
J Bone Joint Surg Am 82:457-76. 2000....
- The influence of alumina and ultra-high molecular weight polyethylene particles on osteoblast-osteoclast cooperationD Granchi
Laboratory of Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, Bologna 40136, Italy
Biomaterials 25:4037-45. 2004..With regard to the inductive effect on the osteoclastogenesis, our results show that the Al(2)O(3) wear debris are less active...
- Comparative fatigue behavior and toughness of remelted and annealed highly crosslinked polyethylenesFrancisco J Medel
Department of Materials Science and Technology, Centro Politécnico Superior I3A, Universidad de Zaragoza, E 50018 Zaragoza, Spain
J Biomed Mater Res B Appl Biomater 83:380-90. 2007Highly cross-linked polyethylenes (HXLPEs) have been incorporated into the hip replacement armamentarium based on their improved wear resistance...
- Does highly cross-linked polyethylene wear less than conventional polyethylene in total hip arthroplasty? A double-blind, randomized, and controlled trial using roentgen stereophotogrammetric analysisSion Glyn-Jones
Nuffield Department of Orthopedic Surgery, University of Oxford, Oxford, UK
J Arthroplasty 23:337-43. 2008..We conclude that HXLPE has a 40% lower wear rate as compared with UHMWPE, suggesting that it will perform better in the long term...
- Radiostereometric analysis comparison of wear of highly cross-linked polyethylene against 36- vs 28-mm femoral headsCharles R Bragdon
Orthopaedic Biomechanics and Biomaterials Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Arthroplasty 22:125-9. 2007..There were no radiographic signs of lysis or radiolucencies at a minimum 3-year follow-up...
- High stress conditions do not increase wear of thin highly crosslinked UHMWPENatalie H Kelly
Department of Biomechanics, Hospital for Special Surgery, 535 E 70th Street, New York, NY 10021, USA
Clin Orthop Relat Res 468:418-23. 2010..Continued monitoring will be necessary to elucidate the clinical efficacy of these devices...
- Ion release in patients with metal-on-metal hip bearings in total joint replacement: a comparison with metal-on-polyethylene bearingsL Savarino
Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
J Biomed Mater Res 63:467-74. 2002..In such a way a risk-to-benefit ratio for the patient could be established...
- A novel method of cross-linking ultra-high-molecular-weight polyethylene to improve wear, reduce oxidation, and retain mechanical properties. Recipient of the 1999 HAP Paul AwardO K Muratoglu
Orthopaedic Biomechanics and Biomaterials Laboratory, Massachusetts General Hospital, GRJ 1206, Boston, MA 02114, USA
J Arthroplasty 16:149-60. 2001..This method leads to the absence of detectable free radicals in the polymer and, as a result, excellent resistance to oxidation of the polymer...
- Mechanism of anterior impingement damage in total knee arthroplastyScott A Banks
The Biomotion Foundation, West Palm Beach, FL 33401, USA
J Bone Joint Surg Am 84:37-42. 2002
- Preparation of UHMWPE particles and establishment of inverted macrophage cell model to investigate wear particles induced bioactivitesHsu Wei Fang
Department of Chemical Engineering and Biotechnology, and Institute of Biotechnology, National Taipei University of Technology, Taipei, Taiwan, ROC
J Biochem Biophys Methods 68:175-87. 2006..This newly developed platform can assist in the further understanding of the mechanism and therapy strategies of osteolysis induced by polyethylene particles...
- New polyethylenes in total hip replacement: a prospective, comparative clinical study of two types of linerE Garcia-Rey
Orthopaedics Department, Hospital Universitario La Paz, Po Castellana 261, 28046 Madrid, Spain
J Bone Joint Surg Br 90:149-53. 2008..Our prospective randomised study has assessed the results using two different polyethylenes associated with the same prosthetic design...
- Development of an extremely wear-resistant ultra high molecular weight polyethylene for total hip replacementsH McKellop
J Vernon Luck Orthopaedic Research Center, and Department of Orthopaedics, University of Southern California, Los Angeles, USA
J Orthop Res 17:157-67. 1999....
- An elasto-plastic finite element model for polyethylene wear in total hip arthroplastyS H Teoh
Laboratory for Biomedical Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
J Biomech 35:323-30. 2002..1 and 0.15 mm where the average linear wear rate was 0.1mm/yr and the volumetric wear was 55 mm(3)/yr. The present work indicates the importance of avoiding too tight or too loose a diametrical clearance...
- Incidence and volume of pelvic osteolysis at early follow-up with highly cross-linked and noncross-linked polyethyleneSerena B Leung
Anderson Orthopaedic Research Institute, Alexandria, Virginia 22307, USA
J Arthroplasty 22:134-9. 2007..Longer follow-up is necessary to determine if Marathon cross-linked polyethylene will continue to demonstrate the encouraging improved wear and osteolysis characteristics...
- Improved mathematical model of the wear of the cup articular surface in hip joint prostheses and comparison with retrieved componentsM T Raimondi
Dipartimento di Bioingegneria, Politecnico di Milano, Italy
Proc Inst Mech Eng H 215:377-91. 2001..The results of the simulations are discussed in relation to the wear distribution measured on the articular surface of 12 UHMWPE components retrieved from failed hip joint prostheses, after a period of in situ functioning...
- Long-term results of rotational total hip arthroplasty: radiological analysisKoji Akasaki
Department of Orthopaedic Surgery, Kumamoto City Hospital, 1-1-60 Koto, Kumamoto 862-0909, Japan
J Orthop Sci 9:126-34. 2004..It is possible that the rotational system reduces the stress against acetabular and femoral components, but the 30 mm diameter head caused high friction torque and required at least 9.5 mm thickness in the acetabular component...
- An axisymmetric contact model of ultra high molecular weight polyethylene cups against metallic femoral heads for artificial hip joint replacementsZ M Jin
Department of Mechanical and Medical Engineering, University of Bradford, UK
Proc Inst Mech Eng H 213:317-27. 1999..The importance of contact mechanics on the clinical performance of artificial hip joint replacements has also been discussed...
- Clinical performance of highly cross-linked polyethylenes in total hip arthroplastyCale A Jacobs
Lexington Clinic, 1221 South Broadway, Lexington, KY 40504, USA
J Bone Joint Surg Am 89:2779-86. 2007..Preclinical laboratory wear testing showed a number of cross-linked polyethylenes to have dramatically less wear than the polyethylene that had been in use for several decades...
- Early failure of a cross-linked polyethylene acetabular liner. A case reportK David Moore
Division of Orthopaedic Surgery, University of Alabama at Birmingham, FOT 920, 510 20th Street South, Birmingham, AL 35294, USA
J Bone Joint Surg Am 90:2499-504. 2008
- Effect of consolidation on adhesive and abrasive wear of ultra high molecular weight polyethyleneRizwan M Gul
Faculty of Metallurgy and Materials Engineering, GIK Institute of Engineering Sciences and Technology, Topi 23460, District Swabi, Pakistan
Biomaterials 24:3193-9. 2003..However, the bi-directional pin-on-disc wear rate did not change with the processing temperature, indicating that adhesive and abrasive wear is independent of the extent of consolidation in the range of parameters studied here...
- Comparison of wear, wear debris and functional biological activity of moderately crosslinked and non-crosslinked polyethylenes in hip prosthesesM Endo
Medical and Biological Engineering, University of Leeds, UK
Proc Inst Mech Eng [H] 216:111-22. 2002..However, this study did not reveal any advantage in terms of predicted FBA for moderately crosslinked UHMWPE compared with non-crosslinked UHMWPE...
- Wear and deformation of ceramic-on-polyethylene total hip replacements with joint laxity and swing phase microseparationS Williams
Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
Proc Inst Mech Eng [H] 217:147-53. 2003..These findings may have significant implications for the choice of fixation systems to be used for different types of bearing couples...
- Nanoindentation properties of compression-moulded ultra-high molecular weight polyethyleneS P Ho
Department of Preventative and Restorative Dental Sciences, University of California San Francisco, San Francisco, USA
Proc Inst Mech Eng [H] 217:357-66. 2003..Additionally, it was concluded that the nanomechanical response of material with higher percentage crystallinity (67 per cent) was predominantly determined by the crystalline regions within the semi-crystalline UHMWPE nanostructure...
- [Tribologic investigation of a metacarpophalangeal prosthesis]C B Rieker
Centerpulse, Winterthur, Schweiz
Orthopade 32:784-8. 2003..Such tests allow the optimisation of the wear behaviour of the tested metacarpophalangeal prosthesis and therefore permit a minimisation of the possible risks to the patients...
- The effect of frictional heating and forced cooling on the serum lubricant and wear of UHMW polyethylene cups against cobalt-chromium and zirconia ballsY S Liao
The J Vernon Luck Orthopaedic Research Center, Orthopaedic Hospital UCLA, Los Angeles, CA, USA
Biomaterials 24:3047-59. 2003....
- In vitro assessment of proximal polyethylene contact surface areas and stresses in mobile bearing kneesP J Chapman-Sheath
Orthopaedic Research Laboratories, Department of Orthopaedics, University of New South Wales, Prince of Wales Hospital, Randwick, NSW 2031, Australia
Med Eng Phys 25:437-43. 2003..Proximal and, to a lesser degree, distal interface contact area footprints decreased significantly with increasing flexion angle based on the conformity of the designs, resulting in a corresponding increase in the mean and peak stresses...
- Tribological behavior of artificial hip joint under the effects of magnetic field in dry and lubricated slidingM Zaki
Department of Production Engineering and Mechanical Design, Faculty of Engineering, Mansoura University, Egypt
Biomed Mater Eng 13:205-21. 2003..The presence of saline lubricant retards the formation of the beneficial polymer transfer thus leading to faster abrasion of the polymeric counterface which explains the relatively rapid and progressive increases in friction and wear...
- In vitro analysis of the wear, wear debris and biological activity of surface-engineered coatings for use in metal-on-metal total hip replacementsS Williams
School of Mechanical Engineering, University of Leeds, UK
Proc Inst Mech Eng [H] 217:155-63. 2003..The reduced wear volumes coupled with the reduced cytotoxicity per unit volume of wear indicate the potential for the clinical application of this technology...
- Comparison of the properties of annealed crosslinked (Crossfire) and conventional polyethylene as hip bearing materialsSteve M Kurtz
Exponent, Inc, Philadelphia, Pennsylvania, USA
Bull Hosp Jt Dis 61:17-26. 2002..Longer follow-up is necessary to confirm the benefits to patients from reduction of debris released from the articulation...
- How do material properties influence wear and fracture mechanisms?Clare Rimnac
Case Western Reserve University, Cleveland, OH, USA
J Am Acad Orthop Surg 16:S94-100. 2008..Mechanical tests as well as computational material and structural models should be developed to evaluate the combined effect of material and geometry (structure) on fracture resistance under clinically relevant loading conditions...
- Knee-simulator testing of conventional and cross-linked polyethylene tibial insertsOrhun K Muratoglu
Orthopaedic Biomechanics and Biomaterials Laboratory, Massachusetts General Hospital, Boston 02114, USA
J Arthroplasty 19:887-97. 2004..In the test model used, oxidation led to delamination, whereas increased cross-link density resulted in reduced adhesive/abrasive wear of tibial inserts...
- A simple fully integrated contact-coupled wear prediction for ultra-high molecular weight polyethylene hip implantsL Kang
Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK
Proc Inst Mech Eng [H] 220:33-46. 2006..Furthermore, if the head diameter increases beyond 42 mm, a rapid increase in the contact pressure was predicted, owing to the decrease in the wall thickness of the cross-linked UHMWPE cup...
- Polyethylene wear particle generation in vivo in an alumina medial pivot total knee prosthesisYukihide Minoda
Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi Abeno-ku Osaka 545-8585, Japan
Biomaterials 26:6034-40. 2005..Alumina MP generated fewer and rounder polyethylene wear particles than metal MP in early clinical stage, and could potentially reduce prevalence of osteolysis and aseptic loosening...
- The integrity of welded interfaces in ultra high molecular weight polyethylene: Part 1-ModelC Paul Buckley
Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, UK
Biomaterials 27:3178-86. 2006..Also, even if Type 1 defects are prevented, Type 2 defects heal extremely slowly. They must be an intrinsic feature of UHMWPE for all reasonable forming conditions, and products and forming processes should be designed accordingly...
- New polymer materials in total hip arthroplasty. Evaluation with radiostereometry, bone densitometry, radiography and clinical parametersGeorgios Digas
Department of Orthopaedics, Institute of Surgical Sciences, Goteborg University, Goteborg, Sweden
Acta Orthop Suppl 76:3-82. 2005..To evaluate the outcome of different types of polyethylene, bone cements and one design of uncemented fixation with porous and ceramic coating using radiostereometry, bone densitometry, conventional radiography and clinical parameters...
- The effect of patient gait on the material properties of UHMWPE in hip replacementsShirley M Davey
Northern Ireland Bioengineering Centre, University of Ulster, Shore Road, Newtownabbey, Co Antrim, Newtownabbey, Northern Ireland BT37 0QB, UK
Biomaterials 26:4993-5001. 2005..Patient kinematics are an important factor affecting the wear and long-term biocompatibility of UHMWPE used as a bearing surface in THR...
- Wear behaviour of cross-linked polyethylene assessed in vitro under severe conditionsSaverio Affatato
Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, Bologna 40136, Italy
Biomaterials 26:3259-67. 2005..The mean equivalent circle diameter was 0.71 and 0.26 microm for UHMWPE and XLPE, respectively...
- The influence of design, materials and kinematics on the in vitro wear of total knee replacementsH M J McEwen
School of Mechanical Engineering, Institute of Medical and Biological Engineering, University of Leeds, Leeds LS2 9JT, UK
J Biomech 38:357-65. 2005..In knee simulator studies, wear of TKR bearings was dependent on kinematics at the articulating surfaces and the prosthesis design, as well as the type of material...
- Computational wear prediction of a total knee replacement from in vivo kinematicsBenjamin J Fregly
Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL 32611, USA
J Biomech 38:305-14. 2005..Total computation time for each damage prediction was less than 30 min. Continuing refinement of this approach will provide a robust tool for accurately predicting clinically relevant wear in total knee replacements...
- Elasto-plastic contact analysis of an ultra-high molecular weight polyethylene tibial component based on geometrical measurement from a retrieved knee prosthesisC H Cho
Department of Mechanical Systems and Environmental Engineering, Faculty of Environmental Engineering, The University of Kitakyushu, 1-1, Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka, 808-0135, Japan
Proc Inst Mech Eng [H] 218:251-9. 2004..The worn surface whose macroscopic geometrical congruity had been improved due to wear after joint replacement showed lower contact stress at macroscopic level...
- Current concepts of metal-on-metal hip resurfacingIan C Clarke
Orthopedic Research Center, 11406 Loma Linda Drive 606, Loma Linda University Medical Center, Loma Linda, CA 92354, USA
Orthop Clin North Am 36:143-62, viii. 2005..This review examines femoral fixation, bone remodeling, and wear studies of MOM implants and provides a brief overview of the latest outcome and retrieval data and how these data integrate with the in vitro wear studies...
- Aseptic loosening, not only a question of wear: a review of different theoriesMikael Sundfeldt
Department of Biomaterials Handicap Research, Sahlgrenska University Hospital, University of Gothenburg, Sweden
Acta Orthop 77:177-97. 2006..In this review, we discuss the most common theories concerning aseptic loosening. It emerges from this review that aseptic loosening has a multifactorial etiology and cannot be explained by a single theory...
- Oxidation in ultrahigh molecular weight polyethylene and cross-linked polyethylene acetabular cups tested against roughened femoral heads in a hip joint simulatorPaola Taddei
Centro di Studio sulla Spettroscopia Raman, Dipartimento di Biochimica G Moruzzi, Sezione di Chimica e Propedeutica Biochimica, Via Belmeloro 8 2, Universita di Bologna, Bologna, Italy
Biomacromolecules 7:1912-20. 2006..Upon simulator testing, UHMWPE showed more significant changes in oxidation indexes and distribution of carbonyl compounds than XLPE, confirming a better wear behavior for XLPE under the adopted testing conditions...
- Wear reduction of orthopaedic bearing surfaces using polyelectrolyte multilayer nanocoatingsPrem V Pavoor
Department of Chemical, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Biomaterials 27:1527-33. 2006..This is the first clinically relevant laboratory demonstration of the wear-reducing ability of these films. Further optimization will be needed before this novel class of materials can be used by the orthopedic community...
- Local head roughening as a factor contributing to variability of total hip wear: a finite element analysisThomas D Brown
Biomechanics Laboratory, Department of Orthopaedic Surgery, 2181 Westlawn, University of Iowa, Iowa City, IA 52242, USA
J Biomech Eng 124:691-8. 2002....
- A comparative joint simulator study of the wear of metal-on-metal and alternative material combinations in hip replacementsA A Goldsmith
DePuy International, a Johnson and Johnson Company, Leeds, UK
Proc Inst Mech Eng H 214:39-47. 2000..The present investigation nevertheless confirms the potential of carefully designed and manufactured metal-on-metal total replacement joints for the treatment of diseased and damaged hips...
- Structural changes of UHMWPE after e-beam irradiation and thermal treatmentMiroslav Slouf
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq 2, 16206 Prague, Czech Republic
J Biomed Mater Res B Appl Biomater 85:240-51. 2008..A simple model, which describes and explains all supermolecular structure changes, is introduced. An effective way of eliminating residual macroradicals in UHMWPE is proposed...
- Thermomechanical analysis of ultra-high molecular weight polyethylene-metal hip prosthesesM Rocchi
Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli, Bologna, Italy
Proc Inst Mech Eng H 221:561-8. 2007..The full coupling between the thermal and the mechanical conditions used in this study appears to be necessary if accurate predictions of the polyethylene deformation are required...
- Metal-on-metal bearings surfaces: materials, manufacture, design, optimization, and alternativesG H Isaac
DePuy International Ltd, Leeds, UK
Proc Inst Mech Eng H 220:119-33. 2006....
- A multi-station hip joint simulator study of the performance of 22 mm diameter zirconia-ultra-high molecular weight polyethylene total replacement hip jointsA A Goldsmith
School of Mechanical Engineering, University of Leeds, UK
Proc Inst Mech Eng H 213:77-90. 1999..022 mm/year...
- A new method to make 2-D wear measurements less sensitive to projection differences of cemented THAsBertram The
Department of Orthopaedic Surgery, University Medical Center Groningen, Hanzeplein 1, Groningen, The Netherlands
Clin Orthop Relat Res 466:684-90. 2008..2 mm was reduced from 35% to 15%. Wear measurements are less sensitive to differences in two-dimensional projection of the THA when using the correction method...
- A two-dimensional model of cyclic strain accumulation in ultra-high molecular weight polyethylene knee replacementsE A Reeves
School of Mechanical Engineering, University of Leeds
Proc Inst Mech Eng H 212:189-98. 1998....
- Prediction of plastic strains in ultra-high molecular weight polyethylene due to microscopic asperity interactions during sliding wearC McNie
School of Mechanical Engineering, University of Leeds
Proc Inst Mech Eng H 212:49-56. 1998..The high plastic strains predicted offer an explanation for the highly elevated wear rates in scratched counterface tests and the aspect ratio of scratch lips is therefore a critical determinant of plastic strain...
- Wear of the high-density polyethylene socket in total hip arthroplasty and its role in endosteal cavitationB M Wroblewski
John Charnley Research Institute, Wrightington Hospital, Wigan, Lancashire
Proc Inst Mech Eng H 211:109-18. 1997..Long-term clinical experience suggests that loosening may be the primary cause while the presence of HDP wear particles is secondary. Healing of endosteal cavities can take place in the presence of HDP wear particles...
- Clinical wear behaviour of ultra-high molecular weight polyethylene cups paired with metal and ceramic ball heads in comparison to metal-on-metal pairings of hip joint replacementsM Semlitsch
Sulzer Orthopaedics Limited, Winterthur, Switzerland
Proc Inst Mech Eng H 211:73-88. 1997..As far as the cup-ball pairing is concerned and under the current pressure of costs, the surgeon should be able to select the optimum hip prosthesis model for every patient from these three categories...
- Factors contributing to the wear of polyethylene in clinical practiceI D Learmonth
Department of Orthopaedic Surgery, University of Bristol
Proc Inst Mech Eng H 211:49-57. 1997..Many of these factors contribute to the wear encountered in clinical practice. These mechanisms are reviewed and examples identified in which they have resulted in increased wear...
- The wear of ultra-high molecular weight polyethylene sliding on metallic and ceramic counterfaces representative of current femoral surfaces in joint replacementJ G Lancaster
Department of Mechanical Engineering, University of Leeds
Proc Inst Mech Eng H 211:17-24. 1997..Although the wear rate decreased less rapidly with decreased counterface roughness for Ra values below 0.05 micron, there were significant advantages to be gained from improved femoral head roughness to below 0.01 micron Ra...
- Wear and morphology of ultra-high molecular weight polyethylene wear particles from total hip replacementsP Campbell
Joint Replacement Institute at Orthopaedic Hospital, Los Angeles, USA
Proc Inst Mech Eng H 210:167-74. 1996..No systematic differences in size and morphology were found between the groups in this study. The similarity in size and morphology of the wear particles suggested that the same basic wear mechanisms were occurring in these components...
- Mechanistic and morphological origins of ultra-high molecular weight polyethylene wear debris in total joint replacement prosthesesA Wang
Howmedica Incorporated, Division of Pfizer Hospital Products Group, Rutherford, New Jersey, USA
Proc Inst Mech Eng H 210:141-55. 1996..Experiments conducted on both gamma irradiated and unirradiated UHMWPE specimens using a linear wear machine and multi-axial joint simulators confirmed the validity of the molecular wear theory...
- Ultra-high molecular weight polyethylene wear debris generated in vivo and in laboratory tests; the influence of counterface roughnessJ L Hailey
Department of Mechanical Engineering, University of Leeds
Proc Inst Mech Eng H 210:3-10. 1996..Of major clinical significance in relation to osteolysis and loosening is roughening of the femoral components, which may lead to greater numbers of the sub-micron-sized particles...
- Development of artificial articular cartilageM Oka
Department of Tissue Regeneration, Institute for Frontier Medical Science, Kyoto University, Japan
Proc Inst Mech Eng H 214:59-68. 2000..The composite osteochondral device became rapidly attached to host bone by ingrowth into the supporting mesh. The clinical implications of the possible use of this material in articular resurfacing and joint replacement are discussed...
- A hip joint simulator study using new and physiologically scratched femoral heads with ultra-high molecular weight polyethylene acetabular cupsP S Barbour
School of Mechanical Engineering, University of Leeds, UK
Proc Inst Mech Eng H 214:569-76. 2000..A greater than twofold increase in wear rate is reported for these heads when compared with smooth heads. This increased wear rate is, however, still within the limits of data from clinical wear studies...
- Morphological characteristics of total joint arthroplasty-derived ultra-high molecular weight polyethylene (UHMWPE) wear debris that provoke inflammation in a murine model of inflammationAllison Sieving
Department of Orthopaedic Surgery, School of Medicine, Detroit, MI 48201, USA
J Biomed Mater Res A 64:457-64. 2003....
- Effect of an accelerated aging protocol on viscoelastic properties of UHMWPEGladius Lewis
Department of Mechanical Engineering, The University of Memphis, TN 38152-3180, USA
Biomed Mater Eng 12:299-308. 2002....
- Tibial interface wear in retrieved total knee components and correlations with modular insert motionAnand R Rao
Anderson Orthopaedic Research Institute, Alexandria, Virginia 22307, USA
J Bone Joint Surg Am 84:1849-55. 2002..New locking mechanism designs directed toward better methods of securing the polyethylene insert to the tibial tray are needed to minimize the generation of particulate wear debris at the modular interface...
- Gamma irradiation alters fatigue-crack behavior and fracture toughness in 1900H and GUR 1050 UHMWPEJantzen C Cole
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Biomed Mater Res 63:559-66. 2002..These results demonstrated that at higher irradiation levels the materials became more brittle in fatigue, with less ductile folding and tearing of the fracture surfaces...
- In vitro comparison of frictional torque and torsional resistance of aged conventional gamma-in-nitrogen sterilized polyethylene versus aged highly crosslinked polyethylene articulating against head sizes larger than 32 mmBrian R Burroughs
Harris Orthopaedic Biomechanics and Biomaterials Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Acta Orthop 77:710-8. 2006....
- Analysis of fluid film lubrication in artificial hip joint replacements with surfaces of high elastic modulusZ M Jin
Department of Mechanical and Manufacturing Engineering, University of Bradford
Proc Inst Mech Eng H 211:247-56. 1997..Therefore, it is important to analyse the contact mechanics in artificial hip joint replacements. Practical considerations of manufacturing these bearing surfaces have also been discussed...
- Effect of contact pressure on wear and friction of ultra-high molecular weight polyethylene in multidirectional slidingV Saikko
Department of Mechanical Engineering, Helsinki University of Technology, P O Box 4300, Helsinki, FIN 02015 HUT, Finland
Proc Inst Mech Eng H 220:723-31. 2006..5 MPa. It appears that the pressure value of 2.0 MPa should not be exceeded in pin-on-disc wear tests that are to reproduce the clinical wear of UHMWPE acetabular cups...
- The wear of cross-linked polyethylene against itselfT J Joyce
Centre for Biomedical Engineering, School of Engineering, University of Durham
Proc Inst Mech Eng H 210:11-6. 1996....
- The wear of metal-on-metal total hip prostheses measured in a hip simulatorS C Scholes
Centre for Biomedical Engineering, School of Engineering, University of Durham, UK
Proc Inst Mech Eng H 215:523-30. 2001..15). The wear rates for all the joints tested were consistent with other simulator studies. The friction factors produced by each joint were found to decrease significantly after wear testing (p < 0.05)...
- A comparison of the wear and physical properties of silane cross-linked polyethylene and ultra-high molecular weight polyethyleneH Sakoda
Department of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, United Kingdom
J Arthroplasty 16:1018-23. 2001Cross-linked polyethylenes are being introduced widely in acetabular cups in hip prostheses as a strategy to reduce the incidence of wear debris-induced osteolysis...
- Surface damage analysis of retrieved highly crosslinked polyethylene tibial components after short-term implantationB M Willie
Bone and Joint Research Lab 151F, SLC VA Health Care System, 500 Foothill Boulevard, Salt Lake City, Utah 84148, USA
J Biomed Mater Res B Appl Biomater 85:114-24. 2008....
- Parameteric optimisation of materials for acetabular cupH S Hedia
Design Department, Faculty of Engineering, Mansoura University, Egypt
Biomed Mater Eng 11:79-88. 2001..6%, respectively...
- Comparative wear and wear debris under three different counterface conditions of crosslinked and non-crosslinked ultra high molecular weight polyethyleneM M Endo
School of Mechanical Engineering, University of Leeds, UK
Biomed Mater Eng 11:23-35. 2001..This has important implications for its osteolytic potential...
- A method for the evaluation of the change in volume of retrieved acetabular cupsM T Raimondi
Laboratory of Biological Structure Mechanics, Dipartimento di Bioingegneria, Politecnico di Milano, Milan, Italy
Proc Inst Mech Eng H 214:577-87. 2000..The uncertainty in the results is estimated for each cup. The repeatability of the technique is studied for a case showing very slight wear. The advantages, disadvantages and limitations of the method are presented and discussed...
- Sterilization and polyethylene wear: clinical studies to support laboratory dataChristi J Sychterz
Anderson Orthopaedic Research Institute, Alexandria, VA 22307, USA
J Bone Joint Surg Am 86:1017-22. 2004....
- Characterization of branched ultrahigh molar mass polymers by asymmetrical flow field-flow fractionation and size exclusion chromatographyT Otte
Postnova Analytics GmbH, Max Planck Straße 14, 86899 Landsberg Lech, Germany
J Chromatogr A 1218:4257-67. 2011..Low density polyethylenes as well as polypropylene and polybutadiene, containing high degrees of branching and high molar masses, have ..
- Characterization of high molecular weight polyethylenes using high temperature asymmetrical flow field-flow fractionation with on-line infrared, light scattering, and viscometry detectionE P C Mes
Analytical Sciences Terneuzen, Dow Benelux B V, 446 Bldg, P O Box 48, 4530 AA, Terneuzen, The Netherlands
J Chromatogr A 1154:319-30. 2007..and viscometry (Visc) detection is introduced as a tool for the characterization of high molecular weight polyethylenes. The high molecular weight fraction strongly affects the rheological behaviour and processability of ..
- The influence of molecular weight, crosslinking and counterface roughness on TNF-alpha production by macrophages in response to ultra high molecular weight polyethylene particlesJoanne Helen Ingram
Department of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
Biomaterials 25:3511-22. 2004The response of murine macrophages to clinically relevant polyethylene wear particles generated from different polyethylenes at various time points and volumetric doses in vitro was evaluated...
- Mesoporous silica supported multiple single-site catalysts and polyethylene reactor blends with tailor-made trimodal and ultra-broad molecular weight distributionsAlexander Kurek
Freiburger Materialforschungszentrum and Institut für Makromolekulare Chemie of the Albert Ludwigs University Freiburg, Stefan Meier Strasse 31, D 79104 Freiburg, Germany
Macromol Rapid Commun 31:1359-63. 2010..As a function of the Fe-2/Cr-1/Cr-2 mixing ratio it is possible to control the weight ratio of these three polyethylenes without affecting the individual average molecular weights and narrow polydispersities of the three ..
- Interaction of oxidation and crosslinking in gamma-irradiated ultrahigh molecular-weight polyethyleneFu Wen Shen
The J Vernon Luck Orthopaedic Research Center, Orthopaedic Hospital, University of California, 2400 S Flower Street, Los Angeles 90007, USA
J Biomed Mater Res 61:430-9. 2002..and had a maximal effect on the surface and subsurface regions for the gamma-air and gamma-low oxygen polyethylenes, respectively...
- How have wear testing and joint simulator studies helped to discriminate among materials and designs?Harry A McKellop
Department of Orthopaedic Surgery, UCLA Orthopaedic Hospital, Los Angeles, CA, USA
J Am Acad Orthop Surg 16:S111-9. 2008..accurate predictions of the in vivo wear of a broad spectrum of bearing materials, including cross-linked polyethylenes, metal-on-metal, ceramic-on-ceramic, and others in development...
- Effect of cross-linking on the microstructure and mechanical properties of ultra-high molecular weight polyethyleneMichael D Ries
Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA 94143, USA
Clin Orthop Relat Res 440:149-56. 2005..Newer "second-generation" highly cross-linked polyethylenes have been developed that are annealed below the melt temperature, but use either a pharmacologic antioxidant, ..
- Wear and osteolysis around total knee arthroplastyDouglas D R Naudie
Division of Orthopaedic Surgery, University of Western Ontario, London Health Sciences Centre, London, ON, Canada
J Am Acad Orthop Surg 15:53-64. 2007..the polyethylene implant influence the extent of wear, and surgeons should be cautious in considering enhanced polyethylenes pending results of further investigations...
- Studies of host response to orthopedic implants and biomaterialsS Santavirta
Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, Finland
J Long Term Eff Med Implants 9:67-76. 1999..However, trials to improve the methylmethacrylate cement or to invent better polyethylenes have often failed...
- Application of a mixture of glycol polyethylenes for the preparation of microcorrosion casts--an observationJerzy A Walocha
Chair of Anatomy, Medical College of Jagiellonian University, Krakow, Poland
Folia Morphol (Warsz) 61:313-6. 2002....
- Reactivity of methacrylates in insertion polymerizationThomas Rünzi
Chemical Materials Science, Department of Chemistry, University of Konstanz, 78464 Konstanz, Germany
J Am Chem Soc 132:16623-30. 2010..Copolymerization of ethylene with a bifunctional acrylate-methacrylate monomer yields linear polyethylenes with intact methacrylate substituents...
- Radiation and chemical crosslinking promote strain hardening behavior and molecular alignment in ultra high molecular weight polyethylene during multi-axial loading conditionsS M Kurtz
Exponent Failure Analysis Associates Inc, Philadelphia, PA 19103, USA
Biomaterials 20:1449-62. 1999..Crosslinking increased the ultimate load at failure and decreased the ultimate displacement of the polyethylenes during the small punch test...
- Reasons for revision of first-generation highly cross-linked polyethylenesSteven M Kurtz
Implant Research Center, School of Biomedical Engineering, Science, and Heath Systems, Drexel University, Philadelphia, Pennsylvania, USA
J Arthroplasty 25:67-74. 2010..The long-term clinical performance of first-generation highly cross-linked liners remains promising based on the midterm outcomes of the components documented in this study [corrected]...
- Constitutive Model for Polyethylenes in Joint ComponentsClare Rimnac; Fiscal Year: 2003..The goal is to improve the long-term performance of UHMWPE joint components, regardless of UHMWPE formulation, through significantly improved numerical modeling of components prior to implantation. ..
- MECHANISMS & PERFORMANCE OF TRACEABLE UHMWPE IMPLANTSSteven Kurtz; Fiscal Year: 2003..clinically retrieved orthopedic components is critically needed to guide the development of improved polyethylenes, such as the highly crosslinked polyethylenes which have recently been introduced into clinical practice for ..
- Constitutive Model for Polyethylenes in Joint ComponentsClare Rimnac; Fiscal Year: 2007..The MDR's and our own implant retrieval experience support that mechanical failure of highly cross linked UHMWPE, albeit in a subset of retrieved cases, is nonetheless a clinically relevant phenomenon. ..
- Hospital and Community Acquired Acute Renal FailureGlenn Chertow; Fiscal Year: 2006..This study will efficiently inform the Nephrology community by providing a foundation of fundamental information (ARF definitions, incidence, consequences and costs) upon which a clinical trials network can be built. ..
- FREEDOM - Frequent Dialysis Outcomes & Markers StudyGlenn Chertow; Fiscal Year: 2006..We are committed to working cooperatively and constructively with the other CCC and Data Analysis Coordinating Center-regardless of the final agreed-upon protocol. ..
- Fatigue Resistant Crosslinked UHMWPE for Total JointsOrhun Muratoglu; Fiscal Year: 2006....
- Infusion of Particles at Implant interfecesStuart Goodman; Fiscal Year: 2006..abstract_text> ..
- Osteolysis and Implant Wear: Biological, Biomedical Engineering, and Surgical PriStuart Goodman; Fiscal Year: 2007....
- Chemokine Directed Cell Trafficking during Continuous Infusion of Wear ParticlesStuart Goodman; Fiscal Year: 2007..This research will elucidate important mechanisms of particle-induced, chemokine-directed cell trafficking and suggest new treatment strategies. ..
- Chemokine Directed Cell Trafficking during Continuous Infusion of Wear ParticlesStuart B Goodman; Fiscal Year: 2010..This research will elucidate important mechanisms of particle-induced, chemokine-directed cell trafficking and suggest new treatment strategies. ..
- Wear, Inflammation and Clinical Performance of Total Disc ReplacementSTEVEN MICHAEL KURTZ; Fiscal Year: 2010..Thus, successful achievement of the proposed research will provide essential information on TDR implant performance and on clinical outcomes, which are needed for informed health care decisions. ..
- Local Biomechanics of Median Nerve Insult in Carpal Tunnel SyndromeThomas Brown; Fiscal Year: 2007....
- Measuring In-Socket Residual Limb Volume FluctuationJoan E Sanders; Fiscal Year: 2010..Thisinstrumentcouldbeextendedtowardstheimplementationand evaluationofnovelvolumecontrolstrategiesandalsoappliedtootherareasof rehabilitationwheremanagementofinterstitialfluidcontrolisclinicallyrelevant. ..
- Evaluation of In Vivo Knee Load Predictions using Instrumented ImplantsBENJAMIN J contact FREGLY; Fiscal Year: 2010..However, before they can be used for this purpose, their predictions need to be validated. This study proposes unique data and methods to perform such a validation with a focus on the knee during walking. ..
- Measuring In-Socket Residual Limb Volume FluctuationJoan Sanders; Fiscal Year: 2009..abstract_text> ..
- Mechanics and Performance of Traceable UHMWPE ImplantsSteven Kurtz; Fiscal Year: 2009....
- Quantifying 3rd Body Challenge in Total Hip ArthroplastyTHOMAS DUDLEY BROWN; Fiscal Year: 2010..of the wear rate improvements otherwise associated with advanced bearing materials such as highly cross-linked polyethylenes. While long recognized as a potential clinical concern, the difficulties of quantifying 3rd body challenge ..
- Examining Racial and Cardiovascular Paradoxes in Chronic Kidney DiseaseKamyar Kalantar Zadeh; Fiscal Year: 2009..to developing new treatment targets beyond traditional (Framingham) CV risk factors to improve poor outcomes in these 2 patient populations and maybe in geriatric populations or those with chronic disease states and similar paradoxes ..
- Wear Analysis of Intervertebral Total Disc ReplacementsThomas Brown; Fiscal Year: 2009....
- Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational StudyMartin A Freilich; Fiscal Year: 2010..This application represents an important step in this ongoing research initiative. ..
- Examining Racial and Cardiovascular Paradoxes in Chronic Kidney DiseaseKamyar Kalantar Zadeh; Fiscal Year: 2010..to developing new treatment targets beyond traditional (Framingham) CV risk factors to improve poor outcomes in these 2 patient populations and maybe in geriatric populations or those with chronic disease states and similar paradoxes ..
- Evaluation of Fiber Biomaterials for Oral ImplantologyMartin Freilich; Fiscal Year: 2005..The primary comparison between these prosthesis designs will be the incidence of Outcomes Requiring Intervention (failure of prosthesis or non-failures requiring intervention) observed over three years of recall examination. ..
- NONLINEAR COMPUTATIONAL BIOMECHANICS OF THE HIPThomas Brown; Fiscal Year: 2004..This partnership proposes to bring together a critical mass of engineers and surgeons, to achieve clinically grounded advances in nonlinear numerical simulations of surgery of the hip. ..
- NEW BIOMATERIALS TO MINIMIZE SCAR TISSUE FORMATIONJoan Sanders; Fiscal Year: 2002..e. soft-tissue complications that require surgical repair through use of a biomaterial. The new materials will prevent scar tissue formation and reduce the occurrence of secondary complications. ..
- Mechanics and Performance of Traceable UHMWPE ImplantsSteven Kurtz; Fiscal Year: 2007....
- Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis PatientsKamyar Kalantar Zadeh; Fiscal Year: 2007....
- The Emu as a Model for Necrotic Femoral Head CollapseThomas Brown; Fiscal Year: 2006..At the project's conclusion, we expect to have filled a longstanding need in the field of osteonecrosis research: an animal model suitable for systematic study of human-implementable interventions to forestall femoral head collapse. ..
- Nutritional/Inflammatory Evaluation of Dialysis PatientsKamyar Kalantar Zadeh; Fiscal Year: 2005....
- Mechanisms of Third Body Acceleration of THA WearThomas Brown; Fiscal Year: 2005..Finally, while highly-crosslinked polyethylenes appear to offer dramatic performance improvement under relatively favorable tribologic conditions, it remains ..