polyethylenes

Summary

Summary: Synthetic thermoplastics that are tough, flexible, inert, and resistant to chemicals and electrical current. They are often used as biocompatible materials for prostheses and implants.

Top Publications

  1. ncbi Larger diameter femoral heads used in conjunction with a highly cross-linked ultra-high molecular weight polyethylene: a new concept
    O K Muratoglu
    Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Arthroplasty 16:24-30. 2001
  2. doi Tradeoffs amongst fatigue, wear, and oxidation resistance of cross-linked ultra-high molecular weight polyethylene
    Sara A Atwood
    Department of Mechanical Engineering, University of California, Berkeley, 2121 Etcheverry Hall, Berkeley, CA 94720, USA
    J Mech Behav Biomed Mater 4:1033-45. 2011
  3. pmc Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles
    Qi Long Lu
    Muscle Cell Biology, Medical Research Council Clinical Science Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Proc Natl Acad Sci U S A 102:198-203. 2005
  4. ncbi Polyethylene liner dissociation in Harris-Galante acetabular components: a report of 7 cases
    Jason Werle
    Division of Orthopaedic Surgery, Stanford University Medical Center, Stanford, California 94305, USA
    J Arthroplasty 17:78-81. 2002
  5. ncbi Comparison of the response of primary murine peritoneal macrophages and the U937 human histiocytic cell line to challenge with in vitro generated clinically relevant UHMWPE particles
    J B Matthews
    Immunology Research Laboratory, Division of Microbiology, The University of Leeds, UK
    Biomed Mater Eng 10:229-40. 2000
  6. pmc Vitamin E diffused, highly crosslinked UHMWPE: a review
    Ebru Oral
    Harris Orthopaedic Laboratory, Massachusetts General Hospital, 55 Fruit St GRJ 1206, Boston, MA 02114, USA
    Int Orthop 35:215-23. 2011
  7. ncbi Ultra high molecular-weight polyethylene (UHMWPE) in total knee replacement: fabrication, sterilisation and wear
    G Blunn
    The Centre for Biomedical Engineering, Institute of Orthopaedics, Stanmore, Middlesex, UK
    J Bone Joint Surg Br 84:946-9. 2002
  8. ncbi Degradation of mechanical properties of UHMWPE acetabular liners following long-term implantation
    Steven M Kurtz
    Implant Research Center, School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA
    J Arthroplasty 18:68-78. 2003
  9. ncbi Reduction of wear volume from ultrahigh molecular weight polyethylene knee components by the addition of vitamin E
    Satoshi Teramura
    Graduate School of Engineering, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto, Kyoto 606 8501, Japan
    J Orthop Res 26:460-4. 2008
  10. pmc The effects of high dose irradiation on the cross-linking of vitamin E-blended ultrahigh molecular weight polyethylene
    Ebru Oral
    Massachusetts General Hospital, Department of Orthopaedic Surgery, USA
    Biomaterials 29:3557-60. 2008

Detail Information

Publications223 found, 100 shown here

  1. ncbi Larger diameter femoral heads used in conjunction with a highly cross-linked ultra-high molecular weight polyethylene: a new concept
    O K Muratoglu
    Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Arthroplasty 16:24-30. 2001
    ..Even for the 46-mm femoral head, wear was reduced significantly using criteria of gravimetric and geometric measurements and morphologic appearance of the machining marks out to 11 million cycles of simulated gait...
  2. doi Tradeoffs amongst fatigue, wear, and oxidation resistance of cross-linked ultra-high molecular weight polyethylene
    Sara A Atwood
    Department of Mechanical Engineering, University of California, Berkeley, 2121 Etcheverry Hall, Berkeley, CA 94720, USA
    J Mech Behav Biomed Mater 4:1033-45. 2011
    ..The tradeoff we have shown in fatigue, wear, and oxidation performance is critical to the material's long-term success in total joint replacements...
  3. pmc Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles
    Qi Long Lu
    Muscle Cell Biology, Medical Research Council Clinical Science Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Proc Natl Acad Sci U S A 102:198-203. 2005
    ..We conclude that a significant therapeutic effect may be achieved by further optimization in dose and regime of administration of antisense oligonucleotide...
  4. ncbi Polyethylene liner dissociation in Harris-Galante acetabular components: a report of 7 cases
    Jason Werle
    Division of Orthopaedic Surgery, Stanford University Medical Center, Stanford, California 94305, USA
    J Arthroplasty 17:78-81. 2002
    ..This procedure may be accompanied by the potential loss of acetabular bone stock, which should be replenished...
  5. ncbi Comparison of the response of primary murine peritoneal macrophages and the U937 human histiocytic cell line to challenge with in vitro generated clinically relevant UHMWPE particles
    J B Matthews
    Immunology Research Laboratory, Division of Microbiology, The University of Leeds, UK
    Biomed Mater Eng 10:229-40. 2000
    ..Moreover, primary murine macrophages have been demonstrated to be a suitable model for studying cell-particle interactions in vitro...
  6. pmc Vitamin E diffused, highly crosslinked UHMWPE: a review
    Ebru Oral
    Harris Orthopaedic Laboratory, Massachusetts General Hospital, 55 Fruit St GRJ 1206, Boston, MA 02114, USA
    Int Orthop 35:215-23. 2011
    ..The clinical outcome of this material will be apparent from the results of prospective, randomised clinical studies...
  7. ncbi Ultra high molecular-weight polyethylene (UHMWPE) in total knee replacement: fabrication, sterilisation and wear
    G Blunn
    The Centre for Biomedical Engineering, Institute of Orthopaedics, Stanmore, Middlesex, UK
    J Bone Joint Surg Br 84:946-9. 2002
  8. ncbi Degradation of mechanical properties of UHMWPE acetabular liners following long-term implantation
    Steven M Kurtz
    Implant Research Center, School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA
    J Arthroplasty 18:68-78. 2003
    ..The results of this study strongly support the hypothesis that the degradation of mechanical properties for the liners occurred during implantation...
  9. ncbi Reduction of wear volume from ultrahigh molecular weight polyethylene knee components by the addition of vitamin E
    Satoshi Teramura
    Graduate School of Engineering, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto, Kyoto 606 8501, Japan
    J Orthop Res 26:460-4. 2008
    ..VE was mixed with GUR 1050 UHMWPE powder at 0.3 wt%, and the tibial components of the knee joint were made by direct compression molding. The VE-added UHMWPE showed consistently lower wear volume throughout the test...
  10. pmc The effects of high dose irradiation on the cross-linking of vitamin E-blended ultrahigh molecular weight polyethylene
    Ebru Oral
    Massachusetts General Hospital, Department of Orthopaedic Surgery, USA
    Biomaterials 29:3557-60. 2008
    ..The long-term oxidative stability of irradiated blends with low vitamin E concentrations has yet to be studied to determine an optimum between cross-link density and long-term oxidative stability...
  11. ncbi Update on UHMWPE research: from the bench to the bedside
    Enrique Gomez-Barrena
    Department of Orthopaedic Surgery, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
    Acta Orthop 79:832-40. 2008
    ..We conclude the review by affirming that today's state-of-the-art material is no longer conventional UHMWPE, but HXLPE.1...
  12. pmc Do tissues from THA revision of highly crosslinked UHMWPE liners contain wear debris and associated inflammation?
    Ryan M Baxter
    School of Biomedical Engineering, Science and Health Systems, Drexel University, 323 Bossone, 3120 Market Street, Philadelphia, PA 19104, USA
    Clin Orthop Relat Res 469:2308-17. 2011
    ..As highly crosslinked UHMWPE revision tissues are only now becoming available, it is possible to examine the presence and association of wear debris with inflammation in early implant loosening...
  13. pmc Vitamin E-stabilized UHMWPE for total joint implants: a review
    Pierangiola Bracco
    Dipartimento di Chimica IFM and NIS Centre of Excellence, Universita di Torino, Via Pietro Guria, 7, 10125, Torino, Italy
    Clin Orthop Relat Res 469:2286-93. 2011
    ..Vitamin E stabilization of UHMWPE was proposed to improve oxidation resistance while maintaining wear resistance and fatigue strength...
  14. pmc Europium stearate additives delay oxidation of UHMWPE for orthopaedic applications: a pilot study
    Luis A Gallardo
    Department of Orthopedic Surgery, Rush University Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
    Clin Orthop Relat Res 469:2294-301. 2011
    ..Because of this, it currently is used in studies for stabilization of polymers such as polyvinyl chloride...
  15. ncbi Interlaboratory studies to determine optimal analytical methods for measuring the oxidation index of UHMWPE
    S M Kurt
    Exponent Inc, Philadelphia, PA 19103, USA
    Biomaterials 22:2875-81. 2001
    ..2%. The results of this interlaboratory research will be a useful basis for the development of a new oxidation index standard for the orthopedics community...
  16. pmc The elimination of free radicals in irradiated UHMWPEs with and without vitamin E stabilization by annealing under pressure
    Ebru Oral
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Biomed Mater Res B Appl Biomater 97:167-74. 2011
    ....
  17. pmc In vivo oxidation contributes to delamination but not pitting in polyethylene components for total knee arthroplasty
    Francisco J Medel
    Implant Research Center, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA
    J Arthroplasty 26:802-10. 2011
    ..Despite the lower oxidation displayed by conventional retrievals, this study provides strong evidence that delamination secondary to in vivo oxidation may occur during the second decade of implantation...
  18. pmc Early failure of a cross-linked polyethylene acetabular liner. A case report
    K David Moore
    Division of Orthopaedic Surgery, University of Alabama at Birmingham, FOT 920, 510 20th Street South, Birmingham, AL 35294, USA
    J Bone Joint Surg Am 90:2499-504. 2008
  19. ncbi Determination of polyethylene wear in total hip replacements with use of digital radiographs
    J M Martell
    Department of Surgery, The University of Chicago, Illinois 60637, USA
    J Bone Joint Surg Am 79:1635-41. 1997
    ..Analysis of nine controls with 2.0 millimeters of wear yielded an average measurement of wear (and a standard deviation) of 1.99 +/- 0.21 millimeters...
  20. ncbi The effect of socket design, materials and liner thickness on the wear of the porous coated anatomic total hip replacement
    A P Elfick
    Centre for Biomedical Engineering, School of Engineering, University of Durham, UK
    Proc Inst Mech Eng H 215:447-57. 2001
    ..No correlation was found between the thickness of the liner and the clinical wear factor. Within the range of thicknesses tested here, UHMWPE thickness is not an influential parameter for the hip prosthesis and this is confirmed..
  21. ncbi Crosslinked polyethylene compared to conventional polyethylene in total hip replacement: pre-clinical evaluation, in-vitro testing and prospective clinical follow-up study
    Carel H Geerdink
    Department of Orthopaedic Surgery, Atrium Medisch Centrum, Heerlen, CX, NL 6401, The Netherlands
    Acta Orthop 77:719-25. 2006
    Polyethylene wear-induced osteolysis is a major cause of implant loosening in total hip arthroplasty. New crosslinked polyethylenes are presumed to give lower wear rates, but no long-term clinical results are available yet.
  22. ncbi Charnley wear model for validation of hip simulators--ball diameter versus polytetrafluoroethylene and polyethylene wear
    I C Clarke
    Howard and Irene Peterson Tribology Laboratory, Loma Linda University Medical Center, California, United States of America
    Proc Inst Mech Eng H 211:25-36. 1997
    ..These data compared well with the clinical data...
  23. ncbi Biological reactions to wear debris in total joint replacement
    E Ingham
    Department of Microbiology, University of Leeds, UK
    Proc Inst Mech Eng H 214:21-37. 2000
    ..It is concluded that the pre-clinical testing of any new materials for joint replacement must include an analysis of the wear particle characteristics and their biological reactivity in addition to the usual assessment of wear...
  24. ncbi Contact stress assessment of conventional and highly crosslinked ultra high molecular weight polyethylene acetabular liners with finite element analysis and pressure sensitive film
    Gordon R Plank
    Harris Orthopaedic Biomechanics and Biomaterials Laboratory, Massachusetts General Hospital, 55 Fruit Street, Jackson 1126, Boston, Massachusetts 02114, USA
    J Biomed Mater Res B Appl Biomater 80:1-10. 2007
    ..Obviously, other considerations will influence the minimum thickness to be recommended...
  25. ncbi Metal-on-metal bearings and hypersensitivity in patients with artificial hip joints. A clinical and histomorphological study
    Hans Georg Willert
    Klinikum der Universität Göttingen, Abteilung Orthopädie, Robert Koch Strasse 40, D 37099 Göttingen, Germany
    J Bone Joint Surg Am 87:28-36. 2005
    ..Therefore, in order to determine the relevance of these symptoms, we performed a study of the clinical data and periprosthetic tissues associated with endoprostheses with a metal-on metal articulation that had been retrieved at revision...
  26. ncbi In vivo degradation of polyethylene liners after gamma sterilization in air
    Steven M Kurtz
    Implant Research Center, School of Biomedical Engineering, Science, and Health Systems and Department of Materials Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA
    J Bone Joint Surg Am 87:815-23. 2005
    ..The purpose of this study was to quantify the extent to which the mechanical properties and oxidation of conventional polyethylene acetabular liners treated with gamma sterilization in air change in vivo...
  27. doi The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particles
    Gerald J Atkins
    Discipline of Orthopaedics and Trauma, The University of Adelaide, Adelaide, SA 5005, Australia
    Biomaterials 30:3672-81. 2009
    ..Overall, our results suggest that PE particles directly induce a change in the phenotype of mature osteoblasts and osteocytes, consistent with the net loss of bone near orthopaedic implants...
  28. ncbi Incidence and volume of pelvic osteolysis at early follow-up with highly cross-linked and noncross-linked polyethylene
    Serena B Leung
    Anderson Orthopaedic Research Institute, Alexandria, Virginia 22307, USA
    J Arthroplasty 22:134-9. 2007
    ..Longer follow-up is necessary to determine if Marathon cross-linked polyethylene will continue to demonstrate the encouraging improved wear and osteolysis characteristics...
  29. ncbi Effect of hydroxyapatite morphology/surface area on the rheology and processability of hydroxyapatite filled polyethylene composites
    R Joseph
    IRC in Biomedical Materials, Queen Mary University of London, Mile End Road, London, E1 4NS, UK
    Biomaterials 23:4295-302. 2002
    ..These changes reduced the temperatures and pressures required for successful processing...
  30. ncbi Assessment of wear in extensively irradiated UHMWPE cups in simulator studies
    Hironobu Oonishi
    H Oonishi Memorial Joint Replacement Institute, Tominaga Hospital, 4 48, 1 chome, Minato Machi, Naniwa ku, Osaka, 556 0017, Japan
    J Biomed Mater Res A 68:52-60. 2004
    ..This indicates that we should take care to ensure that our desire to reduce the wear debris to a zero amount does not result in a modified UHMWPE that lacks the necessary mechanical properties for contemporary metal-backed cup designs...
  31. ncbi Clinical performance of highly cross-linked polyethylenes in total hip arthroplasty
    Cale A Jacobs
    Lexington Clinic, 1221 South Broadway, Lexington, KY 40504, USA
    J Bone Joint Surg Am 89:2779-86. 2007
    ..Preclinical laboratory wear testing showed a number of cross-linked polyethylenes to have dramatically less wear than the polyethylene that had been in use for several decades...
  32. ncbi Mechanism of anterior impingement damage in total knee arthroplasty
    Scott A Banks
    The Biomotion Foundation, West Palm Beach, FL 33401, USA
    J Bone Joint Surg Am 84:37-42. 2002
  33. pmc High stress conditions do not increase wear of thin highly crosslinked UHMWPE
    Natalie H Kelly
    Department of Biomechanics, Hospital for Special Surgery, 535 E 70th Street, New York, NY 10021, USA
    Clin Orthop Relat Res 468:418-23. 2010
    ..Continued monitoring will be necessary to elucidate the clinical efficacy of these devices...
  34. ncbi Surface analysis of early retrieved acetabular polyethylene liners: a comparison of conventional and highly crosslinked polyethylenes
    Orhun K Muratoglu
    Harvard Medical School, Department of Orthopaedic Surgery, Boston, Massachusetts, USA
    J Arthroplasty 19:68-77. 2004
    ..These observations support the hypothesis that the early in vivo scratching of highly cross-linked polyethylene acetabular liners is primarily caused by plastic deformation...
  35. ncbi The influence of alumina and ultra-high molecular weight polyethylene particles on osteoblast-osteoclast cooperation
    D Granchi
    Laboratory of Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, Bologna 40136, Italy
    Biomaterials 25:4037-45. 2004
    ..With regard to the inductive effect on the osteoclastogenesis, our results show that the Al(2)O(3) wear debris are less active...
  36. doi Does highly cross-linked polyethylene wear less than conventional polyethylene in total hip arthroplasty? A double-blind, randomized, and controlled trial using roentgen stereophotogrammetric analysis
    Sion Glyn-Jones
    Nuffield Department of Orthopedic Surgery, University of Oxford, Oxford, UK
    J Arthroplasty 23:337-43. 2008
    ..We conclude that HXLPE has a 40% lower wear rate as compared with UHMWPE, suggesting that it will perform better in the long term...
  37. ncbi Bulk and dispersed aqueous phase behavior of phytantriol: effect of vitamin E acetate and F127 polymer on liquid crystal nanostructure
    Yao Da Dong
    Department of Pharmaceutics, Victoria College of Pharmacy, Monash University, Parkville, Victoria 3052, Australia
    Langmuir 22:9512-8. 2006
    ..Taken together, these results indicate that phytantriol may not only provide an alternative lipid for preparation of liquid crystalline systems in excess water but may also provide access to properties not available when using GMO...
  38. ncbi Radiostereometric analysis comparison of wear of highly cross-linked polyethylene against 36- vs 28-mm femoral heads
    Charles R Bragdon
    Orthopaedic Biomechanics and Biomaterials Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Arthroplasty 22:125-9. 2007
    ..There were no radiographic signs of lysis or radiolucencies at a minimum 3-year follow-up...
  39. ncbi Preparation of UHMWPE particles and establishment of inverted macrophage cell model to investigate wear particles induced bioactivites
    Hsu Wei Fang
    Department of Chemical Engineering and Biotechnology, and Institute of Biotechnology, National Taipei University of Technology, Taipei, Taiwan, ROC
    J Biochem Biophys Methods 68:175-87. 2006
    ..This newly developed platform can assist in the further understanding of the mechanism and therapy strategies of osteolysis induced by polyethylene particles...
  40. ncbi Development of an extremely wear-resistant ultra high molecular weight polyethylene for total hip replacements
    H McKellop
    J Vernon Luck Orthopaedic Research Center, and Department of Orthopaedics, University of Southern California, Los Angeles, USA
    J Orthop Res 17:157-67. 1999
    ....
  41. ncbi Unified wear model for highly crosslinked ultra-high molecular weight polyethylenes (UHMWPE)
    O K Muratoglu
    Massachusetts General Hospital, Orthopaedic Biomechanics Laboratory, Boston 02114, USA
    Biomaterials 20:1463-70. 1999
    ....
  42. ncbi Dissemination of wear particles to the liver, spleen, and abdominal lymph nodes of patients with hip or knee replacement
    R M Urban
    Department of Orthopedic Surgery, The Rush Arthritis and Orthopedic Institute, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Bone Joint Surg Am 82:457-76. 2000
    ....
  43. ncbi Comparative fatigue behavior and toughness of remelted and annealed highly crosslinked polyethylenes
    Francisco J Medel
    Department of Materials Science and Technology, Centro Politécnico Superior I3A, Universidad de Zaragoza, E 50018 Zaragoza, Spain
    J Biomed Mater Res B Appl Biomater 83:380-90. 2007
    Highly cross-linked polyethylenes (HXLPEs) have been incorporated into the hip replacement armamentarium based on their improved wear resistance...
  44. ncbi A novel method of cross-linking ultra-high-molecular-weight polyethylene to improve wear, reduce oxidation, and retain mechanical properties. Recipient of the 1999 HAP Paul Award
    O K Muratoglu
    Orthopaedic Biomechanics and Biomaterials Laboratory, Massachusetts General Hospital, GRJ 1206, Boston, MA 02114, USA
    J Arthroplasty 16:149-60. 2001
    ..This method leads to the absence of detectable free radicals in the polymer and, as a result, excellent resistance to oxidation of the polymer...
  45. doi New polyethylenes in total hip replacement: a prospective, comparative clinical study of two types of liner
    E Garcia-Rey
    Orthopaedics Department, Hospital Universitario La Paz, Po Castellana 261, 28046 Madrid, Spain
    J Bone Joint Surg Br 90:149-53. 2008
    ..Our prospective randomised study has assessed the results using two different polyethylenes associated with the same prosthetic design...
  46. ncbi Processing of hydroxyapatite reinforced ultrahigh molecular weight polyethylene for biomedical applications
    Liming Fang
    Department of Mechanical Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Biomaterials 26:3471-8. 2005
    ..This process resulted in a 90% increase in Young's modulus and a 50% increase in the yield strength of HA/UHMWPE composite, comparing with those of unfilled UHMWPE...
  47. ncbi Alpha-tocopherol-doped irradiated UHMWPE for high fatigue resistance and low wear
    Ebru Oral
    Orthopaedic Biomechanics and Biomaterials Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital, 55 Fruit Street, GRJ 1206, Boston, MA 02114, USA
    Biomaterials 25:5515-22. 2004
    ..The improved fatigue strength is attributed to the increase in plasticity of UHMWPE due to the lipophilic nature of alpha-T...
  48. ncbi Ion release in patients with metal-on-metal hip bearings in total joint replacement: a comparison with metal-on-polyethylene bearings
    L Savarino
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomed Mater Res 63:467-74. 2002
    ..In such a way a risk-to-benefit ratio for the patient could be established...
  49. ncbi The anti-oxidative properties of alpha-tocopherol in gamma-irradiated UHMWPE with respect to fatigue and oxidation resistance
    Nobuyuki Shibata
    Department of Human Engineering, National Institute of Industrial Health, 6 21 1, Nagao, Tama ku, Kawasaki 214 8585, Japan
    Biomaterials 26:5755-62. 2005
    ..Also, the addition of alpha-tocopherol controls macromolecular structures resulting in the improvement of fatigue performance of UHMWPE...
  50. ncbi In vivo oxidation of gamma-barrier-sterilized ultra-high-molecular-weight polyethylene bearings
    Barbara H Currier
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
    J Arthroplasty 22:721-31. 2007
    ..The result of in vivo oxidation is expected to be loss of mechanical properties, and susceptibility of polyethylene bearings to eventual fatigue failure...
  51. pmc The effect of alpha-tocopherol on the oxidation and free radical decay in irradiated UHMWPE
    Ebru Oral
    Harris Orthopaedic Biomechanics and Biomaterials Laboratory, Massachusetts General Hospital, 55 Fruit Street, GRJ 1206, Boston, MA 02114, USA
    Biomaterials 27:5580-7. 2006
    ..In summary, the real-time oxidation behavior of alpha-TPE was consistent with that observed using accelerated aging methods. This new UHMWPE is oxidation resistant and is expected to maintain its properties in the long term...
  52. ncbi Long-term results of rotational total hip arthroplasty: radiological analysis
    Koji Akasaki
    Department of Orthopaedic Surgery, Kumamoto City Hospital, 1 1 60 Koto, Kumamoto 862 0909, Japan
    J Orthop Sci 9:126-34. 2004
    ..It is possible that the rotational system reduces the stress against acetabular and femoral components, but the 30 mm diameter head caused high friction torque and required at least 9.5 mm thickness in the acetabular component...
  53. ncbi An axisymmetric contact model of ultra high molecular weight polyethylene cups against metallic femoral heads for artificial hip joint replacements
    Z M Jin
    Department of Mechanical and Medical Engineering, University of Bradford, UK
    Proc Inst Mech Eng H 213:317-27. 1999
    ..The importance of contact mechanics on the clinical performance of artificial hip joint replacements has also been discussed...
  54. ncbi Improved mathematical model of the wear of the cup articular surface in hip joint prostheses and comparison with retrieved components
    M T Raimondi
    Dipartimento di Bioingegneria, Politecnico di Milano, Italy
    Proc Inst Mech Eng H 215:377-91. 2001
    ..The results of the simulations are discussed in relation to the wear distribution measured on the articular surface of 12 UHMWPE components retrieved from failed hip joint prostheses, after a period of in situ functioning...
  55. ncbi An elasto-plastic finite element model for polyethylene wear in total hip arthroplasty
    S H Teoh
    Laboratory for Biomedical Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    J Biomech 35:323-30. 2002
    ..1 and 0.15 mm where the average linear wear rate was 0.1mm/yr and the volumetric wear was 55 mm(3)/yr. The present work indicates the importance of avoiding too tight or too loose a diametrical clearance...
  56. ncbi Effect of contact pressure on wear and friction of ultra-high molecular weight polyethylene in multidirectional sliding
    V Saikko
    Department of Mechanical Engineering, Helsinki University of Technology, P O Box 4300, Helsinki, FIN 02015 HUT, Finland
    Proc Inst Mech Eng H 220:723-31. 2006
    ..5 MPa. It appears that the pressure value of 2.0 MPa should not be exceeded in pin-on-disc wear tests that are to reproduce the clinical wear of UHMWPE acetabular cups...
  57. ncbi Wear behaviour of cross-linked polyethylene assessed in vitro under severe conditions
    Saverio Affatato
    Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, Bologna 40136, Italy
    Biomaterials 26:3259-67. 2005
    ..The mean equivalent circle diameter was 0.71 and 0.26 microm for UHMWPE and XLPE, respectively...
  58. ncbi In vitro comparison of frictional torque and torsional resistance of aged conventional gamma-in-nitrogen sterilized polyethylene versus aged highly crosslinked polyethylene articulating against head sizes larger than 32 mm
    Brian R Burroughs
    Harris Orthopaedic Biomechanics and Biomaterials Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Acta Orthop 77:710-8. 2006
    ..However, the effect of larger heads on the frictional torque of highly crosslinked polyethylene is unknown...
  59. ncbi Knee-simulator testing of conventional and cross-linked polyethylene tibial inserts
    Orhun K Muratoglu
    Orthopaedic Biomechanics and Biomaterials Laboratory, Massachusetts General Hospital, Boston 02114, USA
    J Arthroplasty 19:887-97. 2004
    ..In the test model used, oxidation led to delamination, whereas increased cross-link density resulted in reduced adhesive/abrasive wear of tibial inserts...
  60. ncbi Elasto-plastic contact analysis of an ultra-high molecular weight polyethylene tibial component based on geometrical measurement from a retrieved knee prosthesis
    C H Cho
    Department of Mechanical Systems and Environmental Engineering, Faculty of Environmental Engineering, The University of Kitakyushu, 1 1, Hibikino, Wakamatsu ku, Kitakyushu, Fukuoka, 808 0135, Japan
    Proc Inst Mech Eng H 218:251-9. 2004
    ..The worn surface whose macroscopic geometrical congruity had been improved due to wear after joint replacement showed lower contact stress at macroscopic level...
  61. ncbi Surface damage analysis of retrieved highly crosslinked polyethylene tibial components after short-term implantation
    B M Willie
    Bone and Joint Research Lab 151F, SLC VA Health Care System, 500 Foothill Boulevard, Salt Lake City, Utah 84148, USA
    J Biomed Mater Res B Appl Biomater 85:114-24. 2008
    ....
  62. ncbi Wear reduction of orthopaedic bearing surfaces using polyelectrolyte multilayer nanocoatings
    Prem V Pavoor
    Department of Chemical, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biomaterials 27:1527-33. 2006
    ..This is the first clinically relevant laboratory demonstration of the wear-reducing ability of these films. Further optimization will be needed before this novel class of materials can be used by the orthopedic community...
  63. ncbi The effect of patient gait on the material properties of UHMWPE in hip replacements
    Shirley M Davey
    Northern Ireland Bioengineering Centre, University of Ulster, Shore Road, Newtownabbey, Co Antrim, Newtownabbey, Northern Ireland BT37 0QB, UK
    Biomaterials 26:4993-5001. 2005
    ..Patient kinematics are an important factor affecting the wear and long-term biocompatibility of UHMWPE used as a bearing surface in THR...
  64. pmc A new method to make 2-D wear measurements less sensitive to projection differences of cemented THAs
    Bertram The
    Department of Orthopaedic Surgery, University Medical Center Groningen, Hanzeplein 1, Groningen, The Netherlands
    Clin Orthop Relat Res 466:684-90. 2008
    ..2 mm was reduced from 35% to 15%. Wear measurements are less sensitive to differences in two-dimensional projection of the THA when using the correction method...
  65. ncbi A simple fully integrated contact-coupled wear prediction for ultra-high molecular weight polyethylene hip implants
    L Kang
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 220:33-46. 2006
    ..Furthermore, if the head diameter increases beyond 42 mm, a rapid increase in the contact pressure was predicted, owing to the decrease in the wall thickness of the cross-linked UHMWPE cup...
  66. ncbi The integrity of welded interfaces in ultra high molecular weight polyethylene: Part 1-Model
    C Paul Buckley
    Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, UK
    Biomaterials 27:3178-86. 2006
    ..Also, even if Type 1 defects are prevented, Type 2 defects heal extremely slowly. They must be an intrinsic feature of UHMWPE for all reasonable forming conditions, and products and forming processes should be designed accordingly...
  67. ncbi Metal-on-metal bearings surfaces: materials, manufacture, design, optimization, and alternatives
    G H Isaac
    DePuy International Ltd, Leeds, UK
    Proc Inst Mech Eng H 220:119-33. 2006
    ....
  68. ncbi Thermomechanical analysis of ultra-high molecular weight polyethylene-metal hip prostheses
    M Rocchi
    Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Proc Inst Mech Eng H 221:561-8. 2007
    ..The full coupling between the thermal and the mechanical conditions used in this study appears to be necessary if accurate predictions of the polyethylene deformation are required...
  69. ncbi How do material properties influence wear and fracture mechanisms?
    Clare Rimnac
    Case Western Reserve University, Cleveland, OH, USA
    J Am Acad Orthop Surg 16:S94-100. 2008
    ..Mechanical tests as well as computational material and structural models should be developed to evaluate the combined effect of material and geometry (structure) on fracture resistance under clinically relevant loading conditions...
  70. ncbi Polyethylene wear particle generation in vivo in an alumina medial pivot total knee prosthesis
    Yukihide Minoda
    Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi Abeno ku Osaka 545 8585, Japan
    Biomaterials 26:6034-40. 2005
    ..Alumina MP generated fewer and rounder polyethylene wear particles than metal MP in early clinical stage, and could potentially reduce prevalence of osteolysis and aseptic loosening...
  71. ncbi Aseptic loosening, not only a question of wear: a review of different theories
    Mikael Sundfeldt
    Department of Biomaterials Handicap Research, Sahlgrenska University Hospital, University of Gothenburg, Sweden
    Acta Orthop 77:177-97. 2006
    ..In this review, we discuss the most common theories concerning aseptic loosening. It emerges from this review that aseptic loosening has a multifactorial etiology and cannot be explained by a single theory...
  72. ncbi Oxidation in ultrahigh molecular weight polyethylene and cross-linked polyethylene acetabular cups tested against roughened femoral heads in a hip joint simulator
    Paola Taddei
    Centro di Studio sulla Spettroscopia Raman, Dipartimento di Biochimica G Moruzzi, Sezione di Chimica e Propedeutica Biochimica, Via Belmeloro 8 2, Universita di Bologna, Bologna, Italy
    Biomacromolecules 7:1912-20. 2006
    ..Upon simulator testing, UHMWPE showed more significant changes in oxidation indexes and distribution of carbonyl compounds than XLPE, confirming a better wear behavior for XLPE under the adopted testing conditions...
  73. ncbi Current concepts of metal-on-metal hip resurfacing
    Ian C Clarke
    Orthopedic Research Center, 11406 Loma Linda Drive 606, Loma Linda University Medical Center, Loma Linda, CA 92354, USA
    Orthop Clin North Am 36:143-62, viii. 2005
    ..This review examines femoral fixation, bone remodeling, and wear studies of MOM implants and provides a brief overview of the latest outcome and retrieval data and how these data integrate with the in vitro wear studies...
  74. ncbi Structural changes of UHMWPE after e-beam irradiation and thermal treatment
    Miroslav Slouf
    Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq 2, 16206 Prague, Czech Republic
    J Biomed Mater Res B Appl Biomater 85:240-51. 2008
    ..A simple model, which describes and explains all supermolecular structure changes, is introduced. An effective way of eliminating residual macroradicals in UHMWPE is proposed...
  75. ncbi New polymer materials in total hip arthroplasty. Evaluation with radiostereometry, bone densitometry, radiography and clinical parameters
    Georgios Digas
    Department of Orthopaedics, Institute of Surgical Sciences, Goteborg University, Goteborg, Sweden
    Acta Orthop Suppl 76:3-82. 2005
    ..To evaluate the outcome of different types of polyethylene, bone cements and one design of uncemented fixation with porous and ceramic coating using radiostereometry, bone densitometry, conventional radiography and clinical parameters...
  76. ncbi The influence of design, materials and kinematics on the in vitro wear of total knee replacements
    H M J McEwen
    School of Mechanical Engineering, Institute of Medical and Biological Engineering, University of Leeds, Leeds LS2 9JT, UK
    J Biomech 38:357-65. 2005
    ..In knee simulator studies, wear of TKR bearings was dependent on kinematics at the articulating surfaces and the prosthesis design, as well as the type of material...
  77. ncbi The wear of cross-linked polyethylene against itself
    T J Joyce
    Centre for Biomedical Engineering, School of Engineering, University of Durham
    Proc Inst Mech Eng H 210:11-6. 1996
    ....
  78. ncbi Development of artificial articular cartilage
    M Oka
    Department of Tissue Regeneration, Institute for Frontier Medical Science, Kyoto University, Japan
    Proc Inst Mech Eng H 214:59-68. 2000
    ..The composite osteochondral device became rapidly attached to host bone by ingrowth into the supporting mesh. The clinical implications of the possible use of this material in articular resurfacing and joint replacement are discussed...
  79. ncbi A hip joint simulator study using new and physiologically scratched femoral heads with ultra-high molecular weight polyethylene acetabular cups
    P S Barbour
    School of Mechanical Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 214:569-76. 2000
    ..A greater than twofold increase in wear rate is reported for these heads when compared with smooth heads. This increased wear rate is, however, still within the limits of data from clinical wear studies...
  80. ncbi A method for the evaluation of the change in volume of retrieved acetabular cups
    M T Raimondi
    Laboratory of Biological Structure Mechanics, Dipartimento di Bioingegneria, Politecnico di Milano, Milan, Italy
    Proc Inst Mech Eng H 214:577-87. 2000
    ..The uncertainty in the results is estimated for each cup. The repeatability of the technique is studied for a case showing very slight wear. The advantages, disadvantages and limitations of the method are presented and discussed...
  81. ncbi Parameteric optimisation of materials for acetabular cup
    H S Hedia
    Design Department, Faculty of Engineering, Mansoura University, Egypt
    Biomed Mater Eng 11:79-88. 2001
    ..6%, respectively...
  82. ncbi Comparative wear and wear debris under three different counterface conditions of crosslinked and non-crosslinked ultra high molecular weight polyethylene
    M M Endo
    School of Mechanical Engineering, University of Leeds, UK
    Biomed Mater Eng 11:23-35. 2001
    ..This has important implications for its osteolytic potential...
  83. ncbi A comparison of the wear and physical properties of silane cross-linked polyethylene and ultra-high molecular weight polyethylene
    H Sakoda
    Department of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, United Kingdom
    J Arthroplasty 16:1018-23. 2001
    Cross-linked polyethylenes are being introduced widely in acetabular cups in hip prostheses as a strategy to reduce the incidence of wear debris-induced osteolysis...
  84. ncbi The wear of metal-on-metal total hip prostheses measured in a hip simulator
    S C Scholes
    Centre for Biomedical Engineering, School of Engineering, University of Durham, UK
    Proc Inst Mech Eng H 215:523-30. 2001
    ..15). The wear rates for all the joints tested were consistent with other simulator studies. The friction factors produced by each joint were found to decrease significantly after wear testing (p < 0.05)...
  85. ncbi Comparison of wear, wear debris and functional biological activity of moderately crosslinked and non-crosslinked polyethylenes in hip prostheses
    M Endo
    Medical and Biological Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 216:111-22. 2002
    ..However, this study did not reveal any advantage in terms of predicted FBA for moderately crosslinked UHMWPE compared with non-crosslinked UHMWPE...
  86. ncbi A comparative joint simulator study of the wear of metal-on-metal and alternative material combinations in hip replacements
    A A Goldsmith
    DePuy International, a Johnson and Johnson Company, Leeds, UK
    Proc Inst Mech Eng H 214:39-47. 2000
    ..The present investigation nevertheless confirms the potential of carefully designed and manufactured metal-on-metal total replacement joints for the treatment of diseased and damaged hips...
  87. ncbi A multi-station hip joint simulator study of the performance of 22 mm diameter zirconia-ultra-high molecular weight polyethylene total replacement hip joints
    A A Goldsmith
    School of Mechanical Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 213:77-90. 1999
    ..022 mm/year...
  88. ncbi A two-dimensional model of cyclic strain accumulation in ultra-high molecular weight polyethylene knee replacements
    E A Reeves
    School of Mechanical Engineering, University of Leeds
    Proc Inst Mech Eng H 212:189-98. 1998
    ....
  89. ncbi Ultra-high molecular weight polyethylene wear debris generated in vivo and in laboratory tests; the influence of counterface roughness
    J L Hailey
    Department of Mechanical Engineering, University of Leeds
    Proc Inst Mech Eng H 210:3-10. 1996
    ..Of major clinical significance in relation to osteolysis and loosening is roughening of the femoral components, which may lead to greater numbers of the sub-micron-sized particles...
  90. ncbi Mechanistic and morphological origins of ultra-high molecular weight polyethylene wear debris in total joint replacement prostheses
    A Wang
    Howmedica Incorporated, Division of Pfizer Hospital Products Group, Rutherford, New Jersey, USA
    Proc Inst Mech Eng H 210:141-55. 1996
    ..Experiments conducted on both gamma irradiated and unirradiated UHMWPE specimens using a linear wear machine and multi-axial joint simulators confirmed the validity of the molecular wear theory...
  91. ncbi Wear and morphology of ultra-high molecular weight polyethylene wear particles from total hip replacements
    P Campbell
    Joint Replacement Institute at Orthopaedic Hospital, Los Angeles, USA
    Proc Inst Mech Eng H 210:167-74. 1996
    ..No systematic differences in size and morphology were found between the groups in this study. The similarity in size and morphology of the wear particles suggested that the same basic wear mechanisms were occurring in these components...
  92. ncbi The wear of ultra-high molecular weight polyethylene sliding on metallic and ceramic counterfaces representative of current femoral surfaces in joint replacement
    J G Lancaster
    Department of Mechanical Engineering, University of Leeds
    Proc Inst Mech Eng H 211:17-24. 1997
    ..Although the wear rate decreased less rapidly with decreased counterface roughness for Ra values below 0.05 micron, there were significant advantages to be gained from improved femoral head roughness to below 0.01 micron Ra...
  93. ncbi Clinical wear behaviour of ultra-high molecular weight polyethylene cups paired with metal and ceramic ball heads in comparison to metal-on-metal pairings of hip joint replacements
    M Semlitsch
    Sulzer Orthopaedics Limited, Winterthur, Switzerland
    Proc Inst Mech Eng H 211:73-88. 1997
    ..As far as the cup-ball pairing is concerned and under the current pressure of costs, the surgeon should be able to select the optimum hip prosthesis model for every patient from these three categories...
  94. ncbi Wear of the high-density polyethylene socket in total hip arthroplasty and its role in endosteal cavitation
    B M Wroblewski
    John Charnley Research Institute, Wrightington Hospital, Wigan, Lancashire
    Proc Inst Mech Eng H 211:109-18. 1997
    ..Long-term clinical experience suggests that loosening may be the primary cause while the presence of HDP wear particles is secondary. Healing of endosteal cavities can take place in the presence of HDP wear particles...
  95. ncbi Analysis of fluid film lubrication in artificial hip joint replacements with surfaces of high elastic modulus
    Z M Jin
    Department of Mechanical and Manufacturing Engineering, University of Bradford
    Proc Inst Mech Eng H 211:247-56. 1997
    ..Therefore, it is important to analyse the contact mechanics in artificial hip joint replacements. Practical considerations of manufacturing these bearing surfaces have also been discussed...
  96. ncbi Prediction of plastic strains in ultra-high molecular weight polyethylene due to microscopic asperity interactions during sliding wear
    C McNie
    School of Mechanical Engineering, University of Leeds
    Proc Inst Mech Eng H 212:49-56. 1998
    ..The high plastic strains predicted offer an explanation for the highly elevated wear rates in scratched counterface tests and the aspect ratio of scratch lips is therefore a critical determinant of plastic strain...
  97. ncbi Computational wear prediction of a total knee replacement from in vivo kinematics
    Benjamin J Fregly
    Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL 32611, USA
    J Biomech 38:305-14. 2005
    ..Total computation time for each damage prediction was less than 30 min. Continuing refinement of this approach will provide a robust tool for accurately predicting clinically relevant wear in total knee replacements...
  98. ncbi Gamma irradiation alters fatigue-crack behavior and fracture toughness in 1900H and GUR 1050 UHMWPE
    Jantzen C Cole
    Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Biomed Mater Res 63:559-66. 2002
    ..These results demonstrated that at higher irradiation levels the materials became more brittle in fatigue, with less ductile folding and tearing of the fracture surfaces...
  99. ncbi In vitro assessment of proximal polyethylene contact surface areas and stresses in mobile bearing knees
    P J Chapman-Sheath
    Orthopaedic Research Laboratories, Department of Orthopaedics, University of New South Wales, Prince of Wales Hospital, Randwick, NSW 2031, Australia
    Med Eng Phys 25:437-43. 2003
    ..Proximal and, to a lesser degree, distal interface contact area footprints decreased significantly with increasing flexion angle based on the conformity of the designs, resulting in a corresponding increase in the mean and peak stresses...
  100. ncbi In vitro analysis of the wear, wear debris and biological activity of surface-engineered coatings for use in metal-on-metal total hip replacements
    S Williams
    School of Mechanical Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 217:155-63. 2003
    ..The reduced wear volumes coupled with the reduced cytotoxicity per unit volume of wear indicate the potential for the clinical application of this technology...
  101. ncbi Comparison of the properties of annealed crosslinked (Crossfire) and conventional polyethylene as hip bearing materials
    Steve M Kurtz
    Exponent, Inc, Philadelphia, Pennsylvania, USA
    Bull Hosp Jt Dis 61:17-26. 2002
    ..Longer follow-up is necessary to confirm the benefits to patients from reduction of debris released from the articulation...

Research Grants69

  1. NEW POLYMERS FOR PERMANENT SOFT DENTURE LINERS
    Lawrence Gettleman; Fiscal Year: 1980
    ..The candidate elastomers are: phosphonitrilic fluoroelastomers, chlorinated polyethylenes, polyurethanes, and triblock domain polymers...
  2. Mechanisms of Third Body Acceleration of THA Wear
    Thomas Brown; Fiscal Year: 2002
    ..Finally, while highly-crosslinked polyethylenes appear to offer dramatic performance improvement under relatively favorable tribologic conditions, it remains ..
  3. Mechanisms of Third Body Acceleration of THA Wear
    Thomas Brown; Fiscal Year: 2003
    ..Finally, while highly-crosslinked polyethylenes appear to offer dramatic performance improvement under relatively favorable tribologic conditions, it remains ..
  4. Wear Particle Disease and NF-kappa B Signaling
    Stuart B Goodman; Fiscal Year: 2012
    ..Polyethylene debris will continue to be generated from TJRs, even with newer polyethylenes that produce smaller, potentially more biologically active particles...
  5. Constitutive Model for Polyethylenes in Joint Components
    Clare Rimnac; Fiscal Year: 2003
    ..The goal is to improve the long-term performance of UHMWPE joint components, regardless of UHMWPE formulation, through significantly improved numerical modeling of components prior to implantation. ..
  6. Constitutive Model for Polyethylenes in Joint Components
    Clare Rimnac; Fiscal Year: 2002
    ..The goal is to improve the long-term performance of UHMWPE joint components, regardless of UHMWPE formulation, through significantly improved numerical modeling of components prior to implantation. ..
  7. Constitutive Model for Polyethylenes in Joint Components
    Clare Rimnac; Fiscal Year: 2001
    ..The goal is to improve the long-term performance of UHMWPE joint components, regardless of UHMWPE formulation, through significantly improved numerical modeling of components prior to implantation. ..
  8. MECHANISMS & PERFORMANCE OF TRACEABLE UHMWPE IMPLANTS
    Steven Kurtz; Fiscal Year: 2003
    ..clinically retrieved orthopedic components is critically needed to guide the development of improved polyethylenes, such as the highly crosslinked polyethylenes which have recently been introduced into clinical practice for ..
  9. MECHANISMS & PERFORMANCE OF TRACEABLE UHMWPE IMPLANTS
    Steven Kurtz; Fiscal Year: 2001
    ..clinically retrieved orthopedic components is critically needed to guide the development of improved polyethylenes, such as the highly crosslinked polyethylenes which have recently been introduced into clinical practice for ..
  10. Constitutive Model for Polyethylenes in Joint Components
    Clare Rimnac; Fiscal Year: 2007
    ..The MDR's and our own implant retrieval experience support that mechanical failure of highly cross linked UHMWPE, albeit in a subset of retrieved cases, is nonetheless a clinically relevant phenomenon. ..
  11. Constitutive Model for Polyethylenes in Joint Components
    Clare Rimnac; Fiscal Year: 2005
    ..The MDR's and our own implant retrieval experience support that mechanical failure of highly cross linked UHMWPE, albeit in a subset of retrieved cases, is nonetheless a clinically relevant phenomenon. ..
  12. Constitutive Model for Polyethylenes in Joint Components
    Clare Rimnac; Fiscal Year: 2006
    ..The MDR's and our own implant retrieval experience support that mechanical failure of highly cross linked UHMWPE, albeit in a subset of retrieved cases, is nonetheless a clinically relevant phenomenon. ..
  13. DRUG BIND SITES:MONOAMINE TRANSP, ANDRENERG & SIMGA RECEPT:PHOTOAFFINITY LABELS
    ARNOLD RUOHO; Fiscal Year: 1999
    ..large part of this work, however the samples run at NMRFAM will be aimed at quantitation of branch carbons in polyethylenes. The quantitation of branch carbons in polyethylene at levels as low as 1/100,000 total carbons is important ..
  14. LOW LEVEL BRANCH ANALYSIS OF POLYETHYLENES
    David Redwine; Fiscal Year: 2000
    ..large part of this work, however the samples run at NMRFAM will be aimed at quantitation of branch carbons in polyethylenes. The quantitation of branch carbons in polyethylene at levels as low as 1/100,000 total carbons is important ..
  15. FREEDOM - Frequent Dialysis Outcomes & Markers Study
    Glenn Chertow; Fiscal Year: 2006
    ..We are committed to working cooperatively and constructively with the other CCC and Data Analysis Coordinating Center-regardless of the final agreed-upon protocol. ..
  16. Hospital and Community Acquired Acute Renal Failure
    Glenn Chertow; Fiscal Year: 2006
    ..This study will efficiently inform the Nephrology community by providing a foundation of fundamental information (ARF definitions, incidence, consequences and costs) upon which a clinical trials network can be built. ..
  17. Fatigue Resistant Crosslinked UHMWPE for Total Joints
    Orhun Muratoglu; Fiscal Year: 2005
    ....
  18. Chemokine Directed Cell Trafficking during Continuous Infusion of Wear Particles
    Stuart Goodman; Fiscal Year: 2008
    ..This research will elucidate important mechanisms of particle-induced, chemokine-directed cell trafficking and suggest new treatment strategies. ..
  19. Chemokine Directed Cell Trafficking during Continuous Infusion of Wear Particles
    Stuart Goodman; Fiscal Year: 2007
    ..This research will elucidate important mechanisms of particle-induced, chemokine-directed cell trafficking and suggest new treatment strategies. ..
  20. Fatigue Resistant Crosslinked UHMWPE for Total Joints
    Orhun Muratoglu; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  21. Infusion of Particles at Implant interfeces
    Stuart Goodman; Fiscal Year: 2006
    ..abstract_text> ..
  22. Osteolysis and Implant Wear: Biological, Biomedical Engineering, and Surgical Pri
    Stuart Goodman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  23. Chemokine Directed Cell Trafficking during Continuous Infusion of Wear Particles
    Stuart Goodman; Fiscal Year: 2009
    ..This research will elucidate important mechanisms of particle-induced, chemokine-directed cell trafficking and suggest new treatment strategies. ..
  24. Fatigue Resistant Crosslinked UHMWPE for Total Joints
    Orhun Muratoglu; Fiscal Year: 2004
    ....
  25. Chemokine Directed Cell Trafficking during Continuous Infusion of Wear Particles
    Stuart B Goodman; Fiscal Year: 2010
    ..This research will elucidate important mechanisms of particle-induced, chemokine-directed cell trafficking and suggest new treatment strategies. ..
  26. Wear Analysis of Intervertebral Total Disc Replacements
    Thomas Brown; Fiscal Year: 2008
    ..abstract_text> ..
  27. Measuring In-Socket Residual Limb Volume Fluctuation
    Joan E Sanders; Fiscal Year: 2010
    ..Thisinstrumentcouldbeextendedtowardstheimplementationand evaluationofnovelvolumecontrolstrategiesandalsoappliedtootherareasof rehabilitationwheremanagementofinterstitialfluidcontrolisclinicallyrelevant. ..
  28. Mechanics and Performance of Traceable UHMWPE Implants
    Steven Kurtz; Fiscal Year: 2008
    ....
  29. Examining Racial and Cardiovascular Paradoxes in Chronic Kidney Disease
    Kamyar Kalantar Zadeh; Fiscal Year: 2008
    ..to developing new treatment targets beyond traditional (Framingham) CV risk factors to improve poor outcomes in these 2 patient populations and maybe in geriatric populations or those with chronic disease states and similar paradoxes ..
  30. Smart Hip Implants with Modified Biological Surface
    Javad Parvizi; Fiscal Year: 2008
    ..As a result, patient pain, suffering and morbidity will be minimized. ..
  31. Musculoskeletal Disorder in Dialysis Patients
    Sharon Moe; Fiscal Year: 2008
    ..These studies, Dr. Moe, and the strong clinical research support at Indiana Unviersity provide an excellent training environment for the development of future investigators in patient oriented research. ..
  32. Local Biomechanics of Median Nerve Insult in Carpal Tunnel Syndrome
    Thomas Brown; Fiscal Year: 2007
    ....
  33. Evaluation of In Vivo Knee Load Predictions using Instrumented Implants
    BENJAMIN J contact FREGLY; Fiscal Year: 2010
    ..However, before they can be used for this purpose, their predictions need to be validated. This study proposes unique data and methods to perform such a validation with a focus on the knee during walking. ..
  34. Local Biomechanics of Median Nerve Insult in Carpal Tunnel Syndrome
    Thomas Brown; Fiscal Year: 2008
    ....
  35. Wear, Inflammation and Clinical Performance of Total Disc Replacement
    STEVEN MICHAEL KURTZ; Fiscal Year: 2010
    ..Thus, successful achievement of the proposed research will provide essential information on TDR implant performance and on clinical outcomes, which are needed for informed health care decisions. ..
  36. Measuring In-Socket Residual Limb Volume Fluctuation
    Joan Sanders; Fiscal Year: 2009
    ..Thisinstrumentcouldbeextendedtowardstheimplementationand evaluationofnovelvolumecontrolstrategiesandalsoappliedtootherareasof rehabilitationwheremanagementofinterstitialfluidcontrolisclinicallyrelevant. ..
  37. Quantifying 3rd Body Challenge in Total Hip Arthroplasty
    THOMAS DUDLEY BROWN; Fiscal Year: 2010
    ..of the wear rate improvements otherwise associated with advanced bearing materials such as highly cross-linked polyethylenes. While long recognized as a potential clinical concern, the difficulties of quantifying 3rd body challenge ..
  38. Mechanics and Performance of Traceable UHMWPE Implants
    Steven Kurtz; Fiscal Year: 2009
    ....
  39. Examining Racial and Cardiovascular Paradoxes in Chronic Kidney Disease
    Kamyar Kalantar Zadeh; Fiscal Year: 2009
    ..to developing new treatment targets beyond traditional (Framingham) CV risk factors to improve poor outcomes in these 2 patient populations and maybe in geriatric populations or those with chronic disease states and similar paradoxes ..
  40. Real-Time Model-Based Gait Retraining for Knee Osteoarthritis Rehabilitation
    Benjamin Fregly; Fiscal Year: 2008
    ..If successful, the approach would allow many patients to delay or possibly even avoid the need for knee replacement surgery in the future. [unreadable] [unreadable]..
  41. Wear Analysis of Intervertebral Total Disc Replacements
    Thomas Brown; Fiscal Year: 2009
    ....
  42. Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study
    Martin A Freilich; Fiscal Year: 2010
    ..This application represents an important step in this ongoing research initiative. ..
  43. Examining Racial and Cardiovascular Paradoxes in Chronic Kidney Disease
    Kamyar Kalantar Zadeh; Fiscal Year: 2010
    ..to developing new treatment targets beyond traditional (Framingham) CV risk factors to improve poor outcomes in these 2 patient populations and maybe in geriatric populations or those with chronic disease states and similar paradoxes ..
  44. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  45. Evaluation of Fiber Biomaterials for Oral Implantology
    Martin Freilich; Fiscal Year: 2005
    ..The primary comparison between these prosthesis designs will be the incidence of Outcomes Requiring Intervention (failure of prosthesis or non-failures requiring intervention) observed over three years of recall examination. ..
  46. NONLINEAR COMPUTATIONAL BIOMECHANICS OF THE HIP
    Thomas Brown; Fiscal Year: 2004
    ..This partnership proposes to bring together a critical mass of engineers and surgeons, to achieve clinically grounded advances in nonlinear numerical simulations of surgery of the hip. ..
  47. The Emu as a Model for Necrotic Femoral Head Collapse
    Thomas Brown; Fiscal Year: 2004
    ..At the project's conclusion, we expect to have filled a longstanding need in the field of osteonecrosis research: an animal model suitable for systematic study of human-implementable interventions to forestall femoral head collapse. ..
  48. Skin Adaptation to Mechanical Stress
    Joan Sanders; Fiscal Year: 2003
    ..By understanding the process of skin adaptation (natural skin strengthening) at both a cellular and molecular level, therapies to encourage skin adaptation before breakdown occurs can be intelligently pursued. ..
  49. NONLINEAR COMPUTATIONAL BIOMECHANICS OF THE HIP
    Thomas Brown; Fiscal Year: 2003
    ..This partnership proposes to bring together a critical mass of engineers and surgeons, to achieve clinically grounded advances in nonlinear numerical simulations of surgery of the hip. ..
  50. Knee Implant Wear Evaluation-An Integrated Approach
    Timothy Wright; Fiscal Year: 2003
    ..abstract_text> ..
  51. MECHANISMS & PERFORMANCE OF TRACEABLE UHMWPE IMPLANTS
    Steven Kurtz; Fiscal Year: 2002
    ..clinically retrieved orthopedic components is critically needed to guide the development of improved polyethylenes, such as the highly crosslinked polyethylenes which have recently been introduced into clinical practice for ..
  52. NEW BIOMATERIALS TO MINIMIZE SCAR TISSUE FORMATION
    Joan Sanders; Fiscal Year: 2002
    ..e. soft-tissue complications that require surgical repair through use of a biomaterial. The new materials will prevent scar tissue formation and reduce the occurrence of secondary complications. ..
  53. ENHANCED THERAPY RESPONSE IN OSTEOSARCOMA
    GENE DIRESTA; Fiscal Year: 2000
    ..The MSKCC Therapeutics faculty believes that the ALS, if successful in this model, has promise as an adjunct for limb salvage procedures and in the treatment of many unresectable or disfiguring tumors. ..
  54. NEW BIOMATERIALS TO MINIMIZE SCAR TISSUE FORMATION
    Joan Sanders; Fiscal Year: 2000
    ..e. soft-tissue complications that require surgical repair through use of a biomaterial. The new materials will prevent scar tissue formation and reduce the occurrence of secondary complications. ..
  55. INTERFACE MECHANICS, MATERIALS AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2004
    ..The development of methods to predict and overcome the detrimental effects of residual limb shape change and ultimately prevent soft-tissue breakdown will help to prevent secondary disability and morbidity in the amputee population. ..
  56. Mechanisms of Third Body Acceleration of THA Wear
    Thomas Brown; Fiscal Year: 2004
    ..Finally, while highly-crosslinked polyethylenes appear to offer dramatic performance improvement under relatively favorable tribologic conditions, it remains ..
  57. Mechanics and Performance of Traceable UHMWPE Implants
    Steven Kurtz; Fiscal Year: 2007
    ....
  58. Examining Racial and Cardiovascular Paradoxes in Chronic Kidney Disease
    Kamyar Kalantar Zadeh; Fiscal Year: 2007
    ..to developing new treatment targets beyond traditional (Framingham) CV risk factors to improve poor outcomes in these 2 patient populations and maybe in geriatric populations or those with chronic disease states and similar paradoxes ..
  59. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  60. Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study
    Martin Freilich; Fiscal Year: 2006
    ..This application represents an important step in this ongoing research initiative. ..
  61. Wear Analysis of Intervertebral Total Disc Replacements
    Thomas Brown; Fiscal Year: 2006
    ..abstract_text> ..
  62. NEW BIOMATERIALS TO MINIMIZE SCAR TISSUE FORMATION
    Joan Sanders; Fiscal Year: 2001
    ..e. soft-tissue complications that require surgical repair through use of a biomaterial. The new materials will prevent scar tissue formation and reduce the occurrence of secondary complications. ..
  63. The Emu as a Model for Necrotic Femoral Head Collapse
    Thomas Brown; Fiscal Year: 2006
    ....
  64. Nutritional/Inflammatory Evaluation of Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2005
    ....
  65. Mechanisms of Third Body Acceleration of THA Wear
    Thomas Brown; Fiscal Year: 2005
    ..Finally, while highly-crosslinked polyethylenes appear to offer dramatic performance improvement under relatively favorable tribologic conditions, it remains ..
  66. ENHANCED THERAPY RESPONSE IN OSTEOSARCOMA
    GENE DIRESTA; Fiscal Year: 1999
    ..The MSKCC Therapeutics faculty believes that the ALS, if successful in this model, has promise as an adjunct for limb salvage procedures and in the treatment of many unresectable or disfiguring tumors. ..
  67. INTERFACE MECHANICS, MATERIALS AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2005
    ..The development of methods to predict and overcome the detrimental effects of residual limb shape change and ultimately prevent soft-tissue breakdown will help to prevent secondary disability and morbidity in the amputee population. ..