microfilament proteins

Summary

Summary: Filaments which are composed primarily of actin and found in the cytoplasmic matrix of almost all cells. They are often associated with microtubules and may play a role in cytoskeletal function and/or mediate movement of the cell or the organelles within the cell.

Top Publications

  1. ncbi Drosophila filamin encoded by the cheerio locus is a component of ovarian ring canals
    N S Sokol
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06510, USA
    Curr Biol 9:1221-30. 1999
  2. ncbi Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein
    Zenzo Isogai
    Department of Biochemistry and Molecular Biology, Shriners Hospital for Children, Oregon Health and Science University, Portland 97239, USA
    J Biol Chem 278:2750-7. 2003
  3. doi Expression of the actin-associated protein transgelin (SM22) is decreased in prostate cancer
    Priya D Prasad
    Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
    Cell Tissue Res 339:337-47. 2010
  4. ncbi Cellular motility driven by assembly and disassembly of actin filaments
    Thomas D Pollard
    Department of Cellular, Molecular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Cell 112:453-65. 2003
  5. pmc Coupling of the nucleus and cytoplasm: role of the LINC complex
    Melissa Crisp
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610
    J Cell Biol 172:41-53. 2006
  6. pmc Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
    Jennifer P Habashi
    Howard Hughes Medical Institute and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 312:117-21. 2006
  7. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
  8. pmc Ezrin, Radixin and Moesin: key regulators of membrane-cortex interactions and signaling
    Amanda L Neisch
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA
    Curr Opin Cell Biol 23:377-82. 2011
  9. ncbi Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
    M Maekawa
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8315, Japan
    Science 285:895-8. 1999
  10. doi miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma
    Masayuki Kano
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Int J Cancer 127:2804-14. 2010

Detail Information

Publications276 found, 100 shown here

  1. ncbi Drosophila filamin encoded by the cheerio locus is a component of ovarian ring canals
    N S Sokol
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06510, USA
    Curr Biol 9:1221-30. 1999
    ..Female sterile cheerio mutants fail to recruit actin to ring canals, disrupting the flow of cytoplasm to oocytes...
  2. ncbi Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein
    Zenzo Isogai
    Department of Biochemistry and Molecular Biology, Shriners Hospital for Children, Oregon Health and Science University, Portland 97239, USA
    J Biol Chem 278:2750-7. 2003
    ..In tissues where LTBP-1 is not expressed, LTBP-4 may substitute for LTBP-1, because the C-terminal end of LTBP-4 binds equally well to fibrillin. A model depicting the relationship between LTBP-1 and fibrillin microfibrils is proposed...
  3. doi Expression of the actin-associated protein transgelin (SM22) is decreased in prostate cancer
    Priya D Prasad
    Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
    Cell Tissue Res 339:337-47. 2010
    ..Thus, transgelin is suppressed during prostate cancer progression and seems to be an important factor in the dysregulation of the actin cytoskeleton...
  4. ncbi Cellular motility driven by assembly and disassembly of actin filaments
    Thomas D Pollard
    Department of Cellular, Molecular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Cell 112:453-65. 2003
    ..Profilin catalyzes the exchange of ADP for ATP, refilling the pool of ATP-actin monomers bound to profilin, ready for elongation...
  5. pmc Coupling of the nucleus and cytoplasm: role of the LINC complex
    Melissa Crisp
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610
    J Cell Biol 172:41-53. 2006
    ..2005), support a model in which Sun proteins tether nesprins in the ONM via interactions spanning the PNS. In this way, Sun proteins and nesprins form a complex that links the nucleoskeleton and cytoskeleton (the LINC complex)...
  6. pmc Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
    Jennifer P Habashi
    Howard Hughes Medical Institute and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 312:117-21. 2006
    ....
  7. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
    ..05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach...
  8. pmc Ezrin, Radixin and Moesin: key regulators of membrane-cortex interactions and signaling
    Amanda L Neisch
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA
    Curr Opin Cell Biol 23:377-82. 2011
    ..In this review we discuss recent evidence in a variety of cells indicating that ERMs serve as scaffolds to facilitate efficient signal transduction on the cytoplasmic face of the plasma membrane...
  9. ncbi Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
    M Maekawa
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8315, Japan
    Science 285:895-8. 1999
    ..These results indicate that phosphorylation of LIM-kinase by ROCK and consequently increased phosphorylation of cofilin by LIM-kinase contribute to Rho-induced reorganization of the actin cytoskeleton...
  10. doi miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma
    Masayuki Kano
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Int J Cancer 127:2804-14. 2010
    ..The identification of tumor-suppressive miRNAs, miR-145, miR-133a and miR-133b, directly control oncogenic FSCN1 gene. These signal pathways of ESCC could provide new insights into potential mechanisms of ESCC carcinogenesis...
  11. ncbi A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage
    Y Imai
    Department of Neurochemistry, National Institute of Neuroscience, Tokyo, Japan
    Biochem Biophys Res Commun 224:855-62. 1996
    ..Iba1 protein is therefore suggested to act as an adapter molecule, mediating calcium signals that may function in a monocytic lineage including microglia...
  12. pmc Organizing the cell cortex: the role of ERM proteins
    Richard G Fehon
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Nat Rev Mol Cell Biol 11:276-87. 2010
    ..Recent studies examining the structure and in vivo functions of ERMs have greatly advanced our understanding of the importance of membrane-cytoskeleton interactions...
  13. ncbi Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
    N Yang
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Nature 393:809-12. 1998
    ..Furthermore, insulin and an active form of Rac increase the activity of LIMK-1. Taken together, our results indicate that LIMK-1 participates in Rac-mediated actin cytoskeletal reorganization, probably by phosphorylating cofilin...
  14. pmc Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site
    R Gary
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Mol Biol Cell 6:1061-75. 1995
    ..The conformationally inaccessible C-terminal region included the F-actin binding site, suggesting that this activity is likewise regulated by masking...
  15. doi Unleashing formins to remodel the actin and microtubule cytoskeletons
    Melissa A Chesarone
    Rosenstiel Basic Medical Science Research Center, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Rev Mol Cell Biol 11:62-74. 2010
    ..The emerging complexity in the mechanisms governing formins mirrors the wide range of essential functions that they perform in cell motility, cell division and cell and tissue morphogenesis...
  16. pmc A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis
    Ulrike Philippar
    Massachusetts Institute of Technology, Koch Institute, Cambridge, MA 02139, USA
    Dev Cell 15:813-28. 2008
    ..Upregulation of Mena(INV) could therefore enable tumor cells to invade in response to otherwise benign EGF stimulus levels...
  17. pmc Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling
    Eloi Montanez
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 28:3132-44. 2009
    ..Our findings show that alpha-pv represents an essential adhesion checkpoint that controls RhoA/ROCK-mediated contractility in vSMCs...
  18. pmc A distinctive role for focal adhesion proteins in three-dimensional cell motility
    Stephanie I Fraley
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Nat Cell Biol 12:598-604. 2010
    ..This study shows that membrane protrusions constitute a critical motility/matrix-traction module that drives cell motility in a 3D matrix...
  19. doi The role of actin, fimbrin and endocytosis in growth of hyphae in Aspergillus nidulans
    Srijana Upadhyay
    Program for the Biology of Filamentous Fungi, Department of Plant Pathology and Microbiology, Texas A and M University, 2132 TAMU, College Station, TX 77843, USA
    Mol Microbiol 68:690-705. 2008
    ..Endocytosis was severely impaired in apolar fimA disruption cells. Our data support a novel apical recycling model which indicates a critical role for actin patch-mediated endocytosis to maintain polarized growth at the apex...
  20. doi The roles of fascins in health and disease
    Yosuke Hashimoto
    Department of Surgery, Shizuoka City Shizuoka Hospital, Shizuoka 420 8630, Japan
    J Pathol 224:289-300. 2011
    ..We discuss the mechanisms by which fascins contribute to disease pathologies, especially cancer, where fascin-1 is emerging as a novel therapeutic target in carcinoma metastasis...
  21. ncbi RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion
    Esther M Lafuente
    Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 7:585-95. 2004
    ..RIAM knockdown displaced Rap1-GTP from the plasma membrane and abrogated Rap1-induced adhesion. Thus, RIAM links Rap1 to integrin activation and plays a role in regulating actin dynamics...
  22. ncbi Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin
    S Naisbitt
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neuron 23:569-82. 1999
    ..Shank may function as a scaffold protein in the PSD, potentially cross-linking NMDA receptor/PSD-95 complexes and coupling them to regulators of the actin cytoskeleton...
  23. doi The revised Ghent nosology for the Marfan syndrome
    Bart L Loeys
    Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, Gent, Belgium
    J Med Genet 47:476-85. 2010
    ..We anticipate that these new guidelines may delay a definitive diagnosis of MFS but will decrease the risk of premature or misdiagnosis and facilitate worldwide discussion of risk and follow-up/management guidelines...
  24. ncbi NUANCE, a giant protein connecting the nucleus and actin cytoskeleton
    Yen Yi Zhen
    Institute for Biochemistry, Medical Faculty, University of Cologne, 50931 Cologne, Germany
    J Cell Sci 115:3207-22. 2002
    ..The C-terminal transmembrane domain is responsible for the targeting the nuclear envelope. Thus, NUANCE is the first alpha-actinin-related protein that has the potential to link the microfilament system with the nucleus...
  25. ncbi Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues
    Q Zhang
    Department of Medicine, Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    J Cell Sci 114:4485-98. 2001
    ..These data and structural analogies with other proteins suggest that nesprins may function as 'dystrophins of the nucleus' to maintain nuclear organization and structural integrity...
  26. pmc Effect of mutation type and location on clinical outcome in 1,013 probands with Marfan syndrome or related phenotypes and FBN1 mutations: an international study
    L Faivre
    Centre de Genetique, Centre Hospitalier Universitaire, Dijon, France
    Am J Hum Genet 81:454-66. 2007
    ..Exon 24-32 mutations define a high-risk group for cardiac manifestations associated with severe prognosis at all ages...
  27. ncbi Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
    F B Gertler
    Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Cell 87:227-39. 1996
    ..Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility...
  28. pmc Novel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation
    Derek T Warren
    British Heart Foundation Centre, Division of Cardiovascular Medicine, King s College London, London SE5 9NU, United Kingdom
    J Biol Chem 285:1311-20. 2010
    ..Taken together, this study suggests that nesprin-2 is a novel intranuclear scaffold, essential for nuclear ERK1/2 signaling fidelity and cell cycle progression...
  29. pmc Effects of small interfering RNAs targeting fascin on human esophageal squamous cell carcinoma cell lines
    Cristian M Ortiz
    Department of Pathology, Valencia University, Hospital General Universitario de Valencia, Avenida tres cruces N degrees 2, CP 46014, Valencia, Spain
    Diagn Pathol 5:41. 2010
    ..Using a stable knockdown cell line, we revealed the effect of fascin on cell growth, cell adhesion and tumor formation...
  30. doi Transgelin promotes migration and invasion of cancer stem cells
    Eun Kyung Lee
    School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
    J Proteome Res 9:5108-17. 2010
    ..Taken together, these results indicate that the metastatic potential of CSCs arises from highly expressed Transgelin...
  31. ncbi Ezrin/radixin/moesin: versatile controllers of signaling molecules and of the cortical cytoskeleton
    Verena Niggli
    Department of Pathology, University of Bern, Murtenstr 31, CH 3010 Bern, Switzerland
    Int J Biochem Cell Biol 40:344-9. 2008
    ..They are involved in cell membrane organization, cell migration, phagocytosis and apoptosis, and may also play cell-specific roles in tumor progression. Their precise involvement in these processes has yet to be elucidated...
  32. pmc Deconstructing the cadherin-catenin-actin complex
    Soichiro Yamada
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 123:889-901. 2005
    ..These results suggest that the linkage between the cadherin-catenin complex and actin filaments is more dynamic than previously appreciated...
  33. pmc Disruption of SM22 promotes inflammation after artery injury via nuclear factor kappaB activation
    Jianbin Shen
    Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA
    Circ Res 106:1351-62. 2010
    ..Abolishing SM22 in apolipoprotein E knockout mice accelerates atherogenesis. However, it is unclear whether SM22 disruption independently promotes arterial inflammation...
  34. pmc Filopodia and adhesion in cancer cell motility
    Antti Arjonen
    Medical Biotechnology VTT Technical Research Centre of Finland
    Cell Adh Migr 5:421-30. 2011
    ..These data implicated that several different filopodia inducing genes may contribute in a collective manner to cancer progression and the high metastasis rates associated with basal-type breast carcinomas...
  35. pmc The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion
    Ang Li
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland, UK
    Curr Biol 20:339-45. 2010
    ..We provide a potential molecular mechanism for how fascin increases the invasiveness of cancer cells, and we compare invadopodia with invasive filopod-like structures in 3D...
  36. pmc Fascin is a key regulator of breast cancer invasion that acts via the modification of metastasis-associated molecules
    Monther Al-Alwan
    Stem Cell Therapy Program, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    PLoS ONE 6:e27339. 2011
    ....
  37. ncbi cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets
    E Butt
    Medizinische Universitatsklinik, Klinische Biochemie und Pathobiochemie, Federal Republic of Germany
    J Biol Chem 269:14509-17. 1994
    ....
  38. pmc Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness
    P J Stewart-Hutchinson
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Cell Res 314:1892-905. 2008
    ....
  39. pmc The tip growth apparatus of Aspergillus nidulans
    Naimeh Taheri-Talesh
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 19:1439-49. 2008
    ..Microtubules are important for delivering vesicles to the tip area and for holding the tip growth apparatus in position...
  40. ncbi Role of actin polymerization and actin cables in actin-patch movement in Schizosaccharomyces pombe
    R J Pelham
    Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, New York 10032, USA
    Nat Cell Biol 3:235-44. 2001
    ..Our studies give rise to a model in which actin patches are centres for actin polymerization that drive their own movement on actin cables using Arp2/3-based actin polymerization...
  41. ncbi Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas
    Socorro Maria Rodriguez-Pinilla
    Breast and Gynecological Cancer Group, Molecular Pathology Programme and Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Clin Cancer Res 12:1533-9. 2006
    ..The aim of this study was to determine whether basal-like phenotype and fascin were related in both sporadic and familial tumors and with prognosis in node-negative sporadic breast cancers...
  42. ncbi Visualization of F-actin localization and dynamics with live cell markers in Neurospora crassa
    Diego L Delgado-Alvarez
    Departamento de Microbiologia, Centro de Investigación Científica y de Educación Superior de Ensenada CICESE, Ensenada, B C, Mexico
    Fungal Genet Biol 47:573-86. 2010
    ..Moreover, Lifeact-GFP marked the broadest spectrum of F-actin structures; it may serve as a global live cell marker for F-actin in filamentous fungi...
  43. doi WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond
    Klemens Rottner
    Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research, Inhoffen Strasse 7, Braunschweig, Germany
    Trends Cell Biol 20:650-61. 2010
    ..Uncovering the physiological relevance of these unique activities will require concerted efforts from multiple disciplines, and is sure to impact our understanding of how the cytoskeleton controls so many dynamic subcellular events...
  44. pmc Identification of filamin as a novel ligand for caveolin-1: evidence for the organization of caveolin-1-associated membrane domains by the actin cytoskeleton
    M Stahlhut
    Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Mol Biol Cell 11:325-37. 2000
    ..The actin network, therefore, seems to be directly involved in the spatial organization of caveolin-1-associated membrane domains...
  45. pmc Dissecting BAR domain function in the yeast Amphiphysins Rvs161 and Rvs167 during endocytosis
    Ji Young Youn
    Department of Molecular Genetics, Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S3E1, Canada
    Mol Biol Cell 21:3054-69. 2010
    ..We show that inappropriate regulation of complex sphingolipid and phosphoinositide levels in the membrane can impinge on Rvs function, highlighting the relationship between membrane components and N-BAR-domain proteins in vivo...
  46. doi Galectin-3 increases gastric cancer cell motility by up-regulating fascin-1 expression
    Seok Jun Kim
    Gastric Cancer Branch, Division of Translational and Clinical Research I, National Cancer Center Research Institute and Hospital, Jungbalsan ro, Ilsandong gu, Goyang si, Gyeonggi Do, Republic of Korea
    Gastroenterology 138:1035-45.e1-2. 2010
    ..Galectin-3 induces cytoskeletal remodeling to increase cell motility, but the mechanisms of this process are not understood. We investigated the effects of galectin-3 on fascin-1, an actin-bundling protein...
  47. ncbi Role of ANC-1 in tethering nuclei to the actin cytoskeleton
    Daniel A Starr
    Howard Hughes Medical Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Science 298:406-9. 2002
    ..Thus, ANC-1 may connect nuclei to the cytoskeleton by interacting with UNC-84 at the nuclear envelope and with actin in the cytoplasm...
  48. ncbi Enaptin, a giant actin-binding protein, is an element of the nuclear membrane and the actin cytoskeleton
    V C Padmakumar
    Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, 50931 Cologne, FRG Germany
    Exp Cell Res 295:330-9. 2004
    ..With the discovery of the actin-binding properties of Enaptin and the highly homologous Nuance, we define a family of proteins that integrate the cytoskeleton with the nucleoskeleton...
  49. pmc Get to grips: steering local actin dynamics with IQGAPs
    Dominique T Brandt
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    EMBO Rep 8:1019-23. 2007
    ....
  50. ncbi Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia
    K Ohsawa
    Department of Neurochemistry, National Institute of Neuroscience, Kodaira, Tokyo 187 8502, Japan
    J Cell Sci 113:3073-84. 2000
    ..These observations suggest that Iba1 is involved in Rac and calcium signaling pathways...
  51. pmc Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family
    D Reczek
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    J Cell Biol 139:169-79. 1997
    ..Since PDZ domains are known to mediate associations with integral membrane proteins, one mode of membrane attachment of ezrin is likely to be mediated through EBP50...
  52. ncbi Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity
    Qiuping Zhang
    Department of Medicine, University of Cambridge, Cambridge, UK
    Hum Mol Genet 16:2816-33. 2007
    ..Taken together, these data suggest that EDMD may be caused, in part, by uncoupling of the nucleoskeleton and cytoskeleton because of perturbed nesprin/emerin/lamin interactions...
  53. ncbi Plakins in development and disease
    Arnoud Sonnenberg
    Division of Cell Biology, The Netherlands Cancer Inst, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Exp Cell Res 313:2189-203. 2007
    ..We will also describe the relationship of these two proteins to the invertebrate plakins, shortstop (shot) in Drosophila and VAB-10 in C. elegans. Finally, we will describe an unusual mammalian plakin, called epiplakin...
  54. pmc Mutations in the TGFβ binding-protein-like domain 5 of FBN1 are responsible for acromicric and geleophysic dysplasias
    Carine Le Goff
    Department of Genetics, Universite Paris Descartes, Unité Institut National de la Santé et de la Recherche Médicale, Hopital Necker Enfants Malades, Paris, France
    Am J Hum Genet 89:7-14. 2011
    ..Although enhanced TGFβ signaling caused by FBN1 mutations can trigger either Marfan syndrome or GD and AD, our findings support the fact that TB5 mutations in FBN1 are responsible for short stature phenotypes...
  55. pmc Differential interactions of the formins INF2, mDia1, and mDia2 with microtubules
    Jérémie Gaillard
    CEA, iRTSV, Laboratoire Physiologie Cellulaire and Végétale, CNRS, UMR5168, Universite Joseph Fourier Grenoble I, F 38054 Grenoble, France
    Mol Biol Cell 22:4575-87. 2011
    ..These differences in interactions with microtubules and actin suggest differential function in cellular processes requiring both cytoskeletal elements...
  56. pmc Fibronectin matrix assembly requires distinct contributions from Rho kinases I and -II
    Atsuko Yoneda
    Division of Biomedical Sciences, Imperial College London, London SW7 2AZ, United Kingdom
    Mol Biol Cell 18:66-75. 2007
    ..Together, two rho kinases contribute to fibronectin matrix assembly in a different manner and cortical myosin II-driven contractility, but not stress fibers, may be critical in this activity...
  57. pmc Migrastatin analogues target fascin to block tumour metastasis
    Lin Chen
    Department of Physiology, Cornell University Weill Medical College, New York, New York 10065, USA
    Nature 464:1062-6. 2010
    ..Our data demonstrate that actin cytoskeletal proteins such as fascin can be explored as new molecular targets for cancer treatment, in a similar manner to the microtubule protein tubulin...
  58. pmc Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2)
    Hua Sun
    Nephrology Division, Department of Medicine, Shanghai Children s Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
    Proc Natl Acad Sci U S A 108:2933-8. 2011
    ..The effects of disease-causing INF2 mutations suggest an important role for this protein and its interaction with other formins in modulating glomerular podocyte phenotype and function...
  59. pmc Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4
    Claudia Stendel
    Institute of Cell Biology, ETH Zurich, Schafmattstrasse 18, CH 8093 Zurich, Switzerland
    Am J Hum Genet 81:158-64. 2007
    ..These data, together with the ability of frabin to induce Cdc42-mediated cell-shape changes in transfected Schwann cells, suggest that Rho GTPase signaling is essential for proper myelination of the peripheral nervous system...
  60. pmc The role of fascin in the migration and invasiveness of malignant glioma cells
    Jeong Hyun Hwang
    Department of Neurosurgery, School of Medicine, Kyungpook National University, Daegu, South Korea
    Neoplasia 10:149-59. 2008
    ..Finally, we show a decreased invasiveness of U251-GFP cells by fascin knockdown in an ex vivo rat brain slice model system. This is the first study to demonstrate a role for fascin in glioma cell morphology, motility, and invasiveness...
  61. ncbi Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker?
    Yosuke Hashimoto
    Department of Cell Biology, Lerner Research Institute, NC1 10, Cleveland Clinic Foundation, OH 44195, USA
    Int J Biochem Cell Biol 37:1787-804. 2005
    ..Here, we discuss the evidence that fascin is upregulated in carcinomas, its contributions to carcinoma cell behaviour and its potential as a candidate novel biomarker or therapeutic target...
  62. pmc Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis
    Michael Carnell
    Cancer Research UK Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, Scotland, UK
    J Cell Biol 193:831-9. 2011
    ..Our data imply a new mechanism, actin-mediated sorting, in which WASH and the Arp2/3 complex polymerize actin on vesicles to drive the separation and recycling of proteins such as the V-ATPase...
  63. pmc Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope
    Thorsten Libotte
    Center for Biochemistry, Medical Faculty, University of Cologne, 50931 Cologne, Germany
    Mol Biol Cell 16:3411-24. 2005
    ..Our data imply a scaffolding function of Nesprin-2 at the nuclear membrane and suggest a potential involvement of this multi-isomeric protein in human disease...
  64. ncbi Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis
    J M Kaplan
    Renal and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 24:251-6. 2000
    ..Our results have implications for understanding the role of the cytoskeleton in the pathophysiology of kidney disease and may lead to a better understanding of the genetic basis of susceptibility to kidney damage...
  65. ncbi Cortactin promotes cell motility by enhancing lamellipodial persistence
    Nicole S Bryce
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Curr Biol 15:1276-85. 2005
    ..However, it is unclear how actin assembly is dynamically regulated to support effective cell migration...
  66. ncbi The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope
    V C Padmakumar
    Center for Biochemistry, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, 50931 Cologne, Germany
    J Cell Sci 118:3419-30. 2005
    ..Our findings propose a conserved nuclear anchorage mechanism between Caenorhabditis elegans and mammals and suggest a model in which Sun1 serves as a ;structural bridge' connecting the nuclear interior with the actin cytoskeleton...
  67. ncbi Structural comparisons of calponin homology domains: implications for actin binding
    S Banuelos
    European Molecular Biology Laboratory Postfach 10 2209 D 69012 Heidelberg, Germany
    Structure 6:1419-31. 1998
    ..The three-dimensional structures of three CH domains are known, but they have not yet clarified the molecular details of the interaction between actin filaments and proteins harbouring CH domains...
  68. pmc Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletons
    C L Leung
    Department of Pathology and Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Biol 147:1275-86. 1999
    ..The properties of MACF are consistent with the observation that mutations in kakapo cause disorganization of microtubules in epidermal muscle attachment cells and some sensory neurons...
  69. ncbi Role of the S. typhimurium actin-binding protein SipA in bacterial internalization
    D Zhou
    Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale School of Medicine, New Haven, CT 06536, USA
    Science 283:2092-5. 1999
    ..These activities result in the spatial localization and more pronounced outward extension of the Salmonella-induced membrane ruffles, thereby facilitating bacterial uptake...
  70. ncbi PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit
    Takashi Tanaka
    Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    Nat Immunol 8:584-91. 2007
    ..Our findings delineate a pathway by which PDLIM2 terminates NF-kappaB activation through intranuclear sequestration and subsequent degradation...
  71. pmc Emergence of large-scale cell morphology and movement from local actin filament growth dynamics
    Catherine I Lacayo
    Department of Biochemistry, Stanford University, Stanford, California, United States of America
    PLoS Biol 5:e233. 2007
    ....
  72. pmc Nuclear versus cytoplasmic localization of filamin A in prostate cancer: immunohistochemical correlation with metastases
    Roble G Bedolla
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Clin Cancer Res 15:788-96. 2009
    ..We have examined whether FlnA localization determines a propensity to metastasis in advanced androgen-independent prostate cancer...
  73. ncbi Ezrin, a key component in tumor metastasis
    Kent W Hunter
    Laboratory of Population Genetics, CCR NCI NIH, 41 Library Drive, Bethesda, MD 20892 5060, USA
    Trends Mol Med 10:201-4. 2004
    ....
  74. ncbi HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma
    Belén Lucas
    Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, D 45122 Essen, Germany
    Oncogene 24:6418-31. 2005
    ..These genes (ACY1, WT1, SELENBP1, COBL, EFHD1, AGXT2L1, ALDH5A1, THEM2, ABCB1, FLJ14146, CSPG2, TRIM9 and HEY1) are good candidates for genes whose activity is changed upon the decrease of HNF4alpha in RCC...
  75. doi Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms
    Christiane Pilop
    Departments of Nephrology and Hypertension, University Hospital of Bern, Bern, Switzerland
    Circulation 120:983-91. 2009
    ..The most life-threatening manifestations are aortic aneurysm and dissection. We investigated changes in the proteome of aortic media in patients with and without MFS to gain insight into molecular mechanisms leading to aortic dilatation...
  76. pmc The Nck-interacting kinase phosphorylates ERM proteins for formation of lamellipodium by growth factors
    Martin Baumgartner
    Department of Cell and Tissue Biology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:13391-6. 2006
    ..These data suggest that direct phosphorylation of ERM proteins by NIK constitutes a signaling mechanism controlling growth factor-induced membrane protrusion and cell morphology...
  77. pmc Proteomic identification of differentially expressed and phosphorylated proteins in epidermis involved in larval-pupal metamorphosis of Helicoverpa armigera
    Qiang Fu
    School of Life Sciences, The Key Laboratory of Plant Cell Engineering and Germplasm Innovation, Ministry of Education, Shandong University, Jinan, 250100, PR China
    BMC Genomics 10:600. 2009
    ..Metamorphosis is an important process in the life cycle of holometabolous insects and is regulated by insect hormones. During metamorphosis, the epidermis goes through a significant transformation at the biochemical and molecular levels...
  78. ncbi Dynamin at the actin-membrane interface
    James D Orth
    Department of Biochemistry and Molecular Biology and The Center for Basic Research in Digestive Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Curr Opin Cell Biol 15:31-9. 2003
    ..Recent data support the concept that the dynamin family might act as a 'polymeric contractile scaffold' at the interface between biological membranes and filamentous actin...
  79. pmc miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer
    T Chiyomaru
    Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    Br J Cancer 102:883-91. 2010
    ..We have recently identified down-regulated microRNAs including miR-145 and miR-133a in bladder cancer (BC). The aim of this study is to determine the genes targeted by miR-145, which is the most down-regulated microRNA in BC...
  80. ncbi Characterization of the microtubule binding domain of microtubule actin crosslinking factor (MACF): identification of a novel group of microtubule associated proteins
    D Sun
    Departments of Pathology and Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Sci 114:161-172. 2001
    ..Plectin and desmoplakin have GSR-containing domains at their C-termini and we further demonstrate that the GSR-containing domain of plectin, but not desmoplakin, can bind to MTs in vivo...
  81. doi Metastasis suppressor 1 (MTSS1) demonstrates prognostic value and anti-metastatic properties in breast cancer
    Christian Parr
    Metastasis and Angiogenesis Research Group, Department of Surgery, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Eur J Cancer 45:1673-83. 2009
    ..We conclude that MTSS1 is a prognostic indicator of disease-free survival in breast cancer patients and demonstrates the ability to play a role in governing the metastatic nature of breast cancer cells...
  82. pmc Nudel modulates kinetochore association and function of cytoplasmic dynein in M phase
    Yun Liang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Mol Biol Cell 18:2656-66. 2007
    ....
  83. ncbi Rho-ROCK-dependent ezrin-radixin-moesin phosphorylation regulates Fas-mediated apoptosis in Jurkat cells
    Marylise Hebert
    Institut National de la Santé et de la Recherche Médicale U749, Faculte de Pharmacie, Chatenay Malabry, France
    J Immunol 181:5963-73. 2008
    ..Thus, phosphorylation of E/M by ROCK is involved in the early steps of apoptotic signaling following Fas triggering and regulates apoptosis induction...
  84. ncbi Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration
    Shiro Suetsugu
    Department of Biochemistry, Institute of Medical Science, University of Tokyo, Tokyo, 108 8639, Japan
    Dev Cell 5:595-609. 2003
    ..Thus, WAVE2 is essential for leading edge extension for directed migration in general and WAVE1 is essential in MMP-dependent migration in ECM...
  85. ncbi Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS
    J B Skeath
    Department of Cell and Structural Biology, Howard Hughes Medical Institute, University of Illinois, Urbana, Illinois 61801, USA
    Development 125:1857-65. 1998
    ..Taken together, these results show that interactions between sanpodo, the Notch signaling pathway and numb enable CNS sibling neurons to acquire different fates...
  86. ncbi Activity-dependent redistribution and essential role of cortactin in dendritic spine morphogenesis
    Heike Hering
    The Picower Center for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 23:11759-69. 2003
    ....
  87. pmc The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction
    Jessica K Sawyer
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 186:57-73. 2009
    ..Instead, Cno localizes to AJs by a Rap1- and actin-dependent mechanism. These data suggest that Cno regulates linkage between AJs and the actin cytoskeleton during morphogenesis...
  88. ncbi Association of cortactin with dynamic actin in lamellipodia and on endosomal vesicles
    M Kaksonen
    Laboratory of Molecular Neurobiology, Department of Biosciences and Institute of Biotechnology, PO Box 56, FIN 00014, University of Helsinki, Finland
    J Cell Sci 113:4421-6. 2000
    ..As cortactin is known to interact with membrane-associated signaling proteins it could have a role in linking signaling complexes with dynamic actin on endosomes and in lamellipodia...
  89. pmc Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex
    H Wu
    Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville 22908
    J Cell Biol 120:1417-26. 1993
    ..We suggest the name cortactin, reflecting the cortical subcellular localization and its actin-binding activity...
  90. pmc Notch3 is required for arterial identity and maturation of vascular smooth muscle cells
    Valérie Domenga
    INSERM E365, Faculté de Médecine Lariboisiere, Paris 75010, France
    Genes Dev 18:2730-5. 2004
    ..We further show that Notch3 is required for arterial specification of vSMC but not of endothelial cells. Our data reveal Notch3 to be the first cell-autonomous regulator of arterial differentiation and maturation of vSMC...
  91. doi Filamins in cell signaling, transcription and organ development
    Alex Xianghua Zhou
    Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, SE 405 30 Goteborg, Sweden
    Trends Cell Biol 20:113-23. 2010
    ..This review focuses on the emerging roles of filamins in cell signaling and transcription, with emphasis on cell motility and organ development...
  92. pmc MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling
    Marina Bershteyn
    Stanford University, CA 94305, USA
    Dev Cell 19:270-83. 2010
    ....
  93. pmc Twinfilin 2 regulates actin filament lengths in cochlear stereocilia
    Anthony W Peng
    Department of Otolaryngology Head and Neck Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 29:15083-8. 2009
    ....
  94. pmc Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli
    G Sekerkova
    Department of Cell and Molecular Biology, Feinberg School of Medicine, and Institute for Neuroscience, Northwestern University, Ward Building 11 185, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Cell Mol Life Sci 63:2329-41. 2006
    ..Certain espin isoforms can also bind phosphatidylinositol 4,5-bisphosphate, profilins or SH3 proteins. These biological activities distinguish espins from other actin-bundling proteins and may make them well-suited to sensory cells...
  95. pmc Arabidopsis VILLIN5, an actin filament bundling and severing protein, is necessary for normal pollen tube growth
    Hua Zhang
    Center for Signal Transduction and Metabolomics, Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
    Plant Cell 22:2749-67. 2010
    ..We propose that VLN5 is a major regulator of actin filament stability and turnover that functions in concert with oscillatory calcium gradients in pollen and therefore plays an integral role in pollen germination and tube growth...
  96. ncbi Messenger RNA expression of podocyte-associated molecules in urinary sediment of patients with lupus nephritis
    Gang Wang
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Rheumatol 34:2358-64. 2007
    ..To examine urinary expression of podocyte-associated molecules in patients with lupus nephritis (LN)...
  97. ncbi A 90 kDa fragment of filamin A promotes Casodex-induced growth inhibition in Casodex-resistant androgen receptor positive C4-2 prostate cancer cells
    Y Wang
    Department of Urology, School of Medicine, University of California Davis, Sacramento, CA, USA
    Oncogene 26:6061-70. 2007
    ..Our results demonstrate that expression of nuclear FlnA is necessary for androgen dependence in these cells...
  98. doi Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia
    Juha Saarikangas
    Institute of Biotechnology, PO Box 56, University of Helsinki, 00014 Finland
    J Cell Sci 124:1245-55. 2011
    ..Collectively, these data demonstrate that MIM modulates interplay between the actin cytoskeleton and plasma membrane to promote the maintenance of intercellular contacts in kidney epithelia...
  99. doi C-terminal Tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer
    Abdulkader Albasri
    Division of Pathology, Nottingham University, Nottingham NG7 2UH, UK
    J Pathol 218:57-65. 2009
    ..Furthermore, Cten induction is associated with post-transcriptional repression of E-cadherin...
  100. ncbi CD28 and CTLA-4 coreceptor expression and signal transduction
    Christopher E Rudd
    Department of Pathology, Cell Signalling Section, University of Cambridge, Cambridge, UK
    Immunol Rev 229:12-26. 2009
    ....
  101. pmc The molecular genetics of Marfan syndrome and related disorders
    P N Robinson
    Institute of Medical Genetics, Charite University Hospital, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    J Med Genet 43:769-87. 2006
    ..Mutations in FBN1 and other genes found in MFS and related disorders will be discussed, and novel concepts concerning the complex and multiple mechanisms of the pathogenesis of MFS will be explained...

Research Grants160 found, 100 shown here

  1. ARCHITECTURAL MICROFIBRILS IN BONE PHYSIOLOGY
    Francesco Ramirez; Fiscal Year: 2007
    ....
  2. ROLES OF MICROFILAMENT PROTEINS IN NEOPLASIA/METASTASIS
    John Leavitt; Fiscal Year: 1991
    ....
  3. ROLES OF MICROFILAMENT PROTEINS AND PLASTIN IN NEOPLASIA
    John Leavitt; Fiscal Year: 1990
    ..We are attempting to clone a cDNA for this rodent cell transformation-sensitive actin so that we can identify the actin isoform and examine its role in rodent cell transformation. (L) ..
  4. GENETIC EXPRESSION PROFILE OF TAXOTERE VERSUS AC
    Jenny Chang; Fiscal Year: 2003
    ..higher RNA expression of mitochrondrial proteins, inflammatory-response proteins, and motility-related microfilament proteins. Resistant tumors show elevated levels of beta tubulin, increased proliferation (KI67), and elevated ..
  5. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2002
    ..abstract_text> ..
  6. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2006
    ..abstract_text> ..
  7. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2007
    ....
  8. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2010
    ....
  9. Motor Systems Supporting Pavlovian Conditioning
    Terry Crow; Fiscal Year: 2004
    ..These studies will help to elucidate general principles underlying the organization of polysensory neural systems generating behavior and their modification by learning. ..
  10. CELLULAR/MOLECULAR ANALYSIS OF SHORT & LONG TERM MEMORY
    Terry Crow; Fiscal Year: 2004
    ..abstract_text> ..
  11. ANALYSIS OF MOTOR SYSTEMS
    Terry Crow; Fiscal Year: 2000
    ..These studies will help elucidate general principles underlying the organization of neural systems generating behavior and its modification by experience. ..
  12. CELLULAR/MOLECULAR ANALYSIS OF SHORT & LONG TERM MEMORY
    Terry Crow; Fiscal Year: 2002
    ..abstract_text> ..
  13. ANALYSIS OF MOTOR SYSTEMS
    Terry Crow; Fiscal Year: 2002
    ..These studies will help elucidate general principles underlying the organization of neural systems generating behavior and its modification by experience. ..
  14. Motor Systems Supporting Pavlovian Conditioning
    Terry Crow; Fiscal Year: 2007
    ..These studies will help to elucidate general principles underlying the organization of polysensory neural systems generating behavior and their modification by learning. ..
  15. Cellular/Molecular Analysis of Short & Long-Term Memory
    Terry Crow; Fiscal Year: 2007
    ..Collectively, these studies of learning and memory will help to elucidate basic mechanisms of short- and long-term memory and provide insights into the relationship between memory mechanisms and clinical disorders of memory . ..
  16. Cellular/Molecular Analysis of Short & Long-Term Memory
    Terry Crow; Fiscal Year: 2008
    ..Collectively, these studies of learning and memory will help to elucidate basic mechanisms of short- and long-term memory and provide insights into the relationship between memory mechanisms and clinical disorders of memory . ..
  17. CELLULAR/MOLECULAR ANALYSIS OF SHORT & LONG TERM MEMORY
    Terry Crow; Fiscal Year: 2001
    ..abstract_text> ..
  18. ANALYSIS OF MOTOR SYSTEMS
    Terry Crow; Fiscal Year: 2001
    ..These studies will help elucidate general principles underlying the organization of neural systems generating behavior and its modification by experience. ..
  19. Motor Systems Supporting Pavlovian Conditioning
    Terry Crow; Fiscal Year: 2008
    ..These studies will help to elucidate general principles underlying the organization of polysensory neural systems generating behavior and their modification by learning. ..
  20. CELLULAR/MOLECULAR ANALYSIS OF SHORT & LONG TERM MEMORY
    Terry Crow; Fiscal Year: 2003
    ..abstract_text> ..
  21. Cellular/Molecular Analysis of Short & Long-Term Memory
    Terry Crow; Fiscal Year: 2009
    ..Collectively, these studies of learning and memory will help to elucidate basic mechanisms of short- and long-term memory and provide insights into the relationship between memory mechanisms and clinical disorders of memory . ..
  22. Cellular/Molecular Analysis of Short & Long-Term Memory
    Terry Crow; Fiscal Year: 2006
    ..Collectively, these studies of learning and memory will help to elucidate basic mechanisms of short- and long-term memory and provide insights into the relationship between memory mechanisms and clinical disorders of memory . ..
  23. ANALYSIS OF MOTOR SYSTEMS
    Terry Crow; Fiscal Year: 1999
    ..These studies will help elucidate general principles underlying the organization of neural systems generating behavior and its modification by experience. ..
  24. Cellular/Molecular Analysis of Short & Long-Term Memory
    TERRY J CROW; Fiscal Year: 2010
    ..Collectively, these studies of learning and memory will help to elucidate basic mechanisms of short- and long-term memory and provide insights into the relationship between memory mechanisms and clinical disorders of memory . ..
  25. Motor Systems Supporting Pavlovian Conditioning
    Terry Crow; Fiscal Year: 2005
    ..These studies will help to elucidate general principles underlying the organization of polysensory neural systems generating behavior and their modification by learning. ..
  26. Motor Systems Supporting Pavlovian Conditioning
    Terry Crow; Fiscal Year: 2006
    ..These studies will help to elucidate general principles underlying the organization of polysensory neural systems generating behavior and their modification by learning. ..
  27. CELLULAR/MOLECULAR ANALYSIS OF SHORT & LONG TERM MEMORY
    Terry Crow; Fiscal Year: 2000
    ..abstract_text> ..
  28. Pathophysiology of Basement Membrane Zone Collagens
    Francesco Ramirez; Fiscal Year: 2007
    ....
  29. Skyscan 1172 ex-vivo microComputed Tomography System
    Francesco Ramirez; Fiscal Year: 2007
    ..Acquisition of this equipment will enable our institutions to engage in biomedical research highly relevant to pathophysiological processes and animal models of human diseases. [unreadable] [unreadable] [unreadable]..
  30. PPARgamma Signaling/Lung Fibroblast Transdifferentiation
    Virender Rehan; Fiscal Year: 2005
    ..abstract_text> ..
  31. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2001
    ....
  32. Fibroblast Cell Signaling in Utero Nicotine-Induced Lung Injury
    Virender K Rehan; Fiscal Year: 2010
    ....
  33. PPAR gamma Signaling and Lung Fibroblast Transdifferentiation
    Virender Rehan; Fiscal Year: 2008
    ..abstract_text> ..
  34. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2007
    ..abstract_text> ..
  35. CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2006
    ....
  36. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2006
    ..abstract_text> ..
  37. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2005
    ..abstract_text> ..
  38. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2005
    ..abstract_text> ..
  39. Investigation of Myofibillar Myopathies
    Duygu Selcen; Fiscal Year: 2008
    ..abstract_text> ..
  40. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2003
    ..abstract_text> ..
  41. Fibroblast Cell Signaling in Utero Nicotine-Induced Lung Injury
    Virender K Rehan; Fiscal Year: 2010
    ....
  42. CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2001
    ..abstract_text> ..
  43. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2008
    ....
  44. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2001
    ....
  45. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2002
    ....
  46. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2000
    ....
  47. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2003
    ..abstract_text> ..
  48. Fibroblast Cell Signaling in Utero Nicotine-Induced Lung Injury
    Virender Rehan; Fiscal Year: 2009
    ....
  49. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2004
    ..abstract_text> ..
  50. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2009
    ....
  51. CD44/VARIANT-CYTOSKELETON IN ADHESION AND BREAST CANCERS
    LILLY BOURGUIGNON; Fiscal Year: 1999
    ..The availability of antibodies against CD44v (unique for metastatic breast carcinomas) should prove to be very useful reagents for monitoring the progression and/or predicting the recurrence of metastatic breast carcinomas. ..
  52. CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2004
    ..abstract_text> ..
  53. CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSION
    LILLY YW BOURGUIGNON; Fiscal Year: 2010
    ....
  54. CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2007
    ....
  55. CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2002
    ..abstract_text> ..
  56. Regulation of formins and cell polarity in yeast
    Bruce L Goode; Fiscal Year: 2010
    ....
  57. Mechanisms of Formin-Mediated Actin Filament Assembly in Fission Yeast
    David R Kovar; Fiscal Year: 2010
    ....
  58. MECHNISMS REGULATING ACTIN ASSEMBLY
    BRUCE GOODE; Fiscal Year: 2004
    ....
  59. Regulation of formins and cell polarity in yeast
    BRUCE GOODE; Fiscal Year: 2008
    ....
  60. PPAR gamma Signaling and Lung Fibroblast Transdifferentiation
    Virender Rehan; Fiscal Year: 2009
    ..abstract_text> ..
  61. THIN FILAMENTS AND MUSCLE REGULATION
    William Lehman; Fiscal Year: 2008
    ....
  62. Mechanisms Regulating Actin Cytoskeleton Dynamics
    BRUCE GOODE; Fiscal Year: 2007
    ....
  63. EM & TIRF analysis of Arp2/3 complex and actin assembly
    BRUCE GOODE; Fiscal Year: 2008
    ..The PI will be directly involved in the integration of TIRF microscopy and single particle imaging into his research program. ..
  64. Fascin Protrusions in ECM-Cytoskeletal Networking
    Josephine Adams; Fiscal Year: 2007
    ....
  65. Mechanisms Regulating Actin Cytoskeleton Dynamics
    BRUCE GOODE; Fiscal Year: 2008
    ....
  66. Fibroblast Cell Signaling in Utero Nicotine-Induced Lung Injury
    Virender Rehan; Fiscal Year: 2008
    ....
  67. Regulation of formins and cell polarity in yeast
    BRUCE GOODE; Fiscal Year: 2009
    ....
  68. PPAR gamma Signaling and Lung Fibroblast Transdifferentiation
    Virender Rehan; Fiscal Year: 2007
    ..abstract_text> ..
  69. Investigation of Myofibillar Myopathies
    Duygu Selcen; Fiscal Year: 2007
    ..abstract_text> ..
  70. Fascin Protrusions in ECM-Cytoskeletal Networking
    Josephine Adams; Fiscal Year: 2003
    ....
  71. Fascin Protrusions in ECM-Cytoskeletal Networking
    Josephine Adams; Fiscal Year: 2004
    ....
  72. MECHNISMS REGULATING ACTIN ASSEMBLY
    BRUCE GOODE; Fiscal Year: 2005
    ....
  73. THIN FILAMENTS AND MUSCLE REGULATION
    William Lehman; Fiscal Year: 2001
    ..e. processes that are essential to all normal cells and that can become aberrant in malignancy. ..
  74. Fascin Protrusions in ECM-Cytoskeletal Networking
    Josephine Adams; Fiscal Year: 2005
    ....
  75. FUNCTION OF MERLIN, A DROSOPHILA NF2 GENE HOMOLOGUE
    Richard Fehon; Fiscal Year: 2003
    ..Finally, these studies should contribute to work on the mechanisms by which cellular interactions function to control cell growth and determine cell fate during development. ..
  76. FUNCTION OF MERLIN, A DROSOPHILA NF2 GENE HOMOLOGUE
    Richard Fehon; Fiscal Year: 2004
    ..Finally, these studies should contribute to work on the mechanisms by which cellular interactions function to control cell growth and determine cell fate during development ..
  77. Calcium Sensing Receptor Signaling in the Gastrointestinal Tract
    Osvaldo Rey; Fiscal Year: 2007
    ..We also anticipate that these mechanistic studies will be extended to normal colon epithelial cells and thus provide a robust base for the formulation of an R01 award application. ..
  78. SYNAPTOPODIN: BIOGENESIS & PLASTICITY OF SPINE APPARATUS
    Peter Mundel; Fiscal Year: 2008
    ..This should in the long-term enable us to develop novel therapies that tackle learning deficiencies and memory loss by modulating the expression of synaptopodin thereby promoting the cellular plasticity of the dendritic spine apparatus. ..
  79. Role of B7-1 in Podocytes in Pathogenesis of Proteinuria
    Peter Mundel; Fiscal Year: 2007
    ..This should in the long-term enable us to develop novel, selective podocyte-protective therapies that tackle proteinuria and progression of glomerulosclerosis by blocking the activity of B7-1 in podocytes. ..
  80. Proteolytic Regulation of Podocyte Function by Cathepsin L
    Jochen Reiser; Fiscal Year: 2008
    ....
  81. CELL AND MOLECULAR BIOLOGICAL ANALYSIS OF SYNAPTOPODIN
    Peter Mundel; Fiscal Year: 2004
    ..These studies should reveal whether synaptopodin functions in stabilization of the actin cytoskeleton and in providing podocyte resistance to strain and whether synpo-!- mice may be prone to the development of glomerular injury. ..
  82. Role of B7-1 in Podocytes in Pathogenesis of Proteinuria
    Peter Mundel; Fiscal Year: 2009
    ..This should in the long-term enable us to develop novel, selective podocyte-protective therapies that tackle proteinuria and progression of glomerulosclerosis by blocking the activity of B7-1 in podocytes. ..
  83. FUNCTION OF MERLIN, A DROSOPHILA NF2 GENE HOMOLOGUE
    Richard Fehon; Fiscal Year: 2008
    ..Finally, these studies should contribute to work on the mechanisms by which cellular interactions function to control cell growth and determine cell fate during development ..
  84. Calcium Sensing Receptor Signaling in the Gastrointestinal Tract
    Osvaldo Rey; Fiscal Year: 2008
    ..We also anticipate that these mechanistic studies will be extended to normal colon epithelial cells and thus provide a robust base for the formulation of an R01 award application. ..
  85. SACRAL CREST CELLS AND ENTERIC NEURODEVELOPMENT
    Raj Kapur; Fiscal Year: 2001
    ..The results of this study will further our understanding of normal enteric neurodevelopment and congenital disorders of intestinal motility. ..
  86. Molecular Mechanisms of Mesangial Sclerosis
    Christine Abrass; Fiscal Year: 2009
    ..Understanding transcriptional control of LN isoform expression will add new insights into the role that LN plays in normal glomerulogenesis and that becomes disordered in glomerular disease. ..
  87. Functions of the Epithelial Septate Junction
    Richard Fehon; Fiscal Year: 2008
    ..abstract_text> ..
  88. SYNAPTOPODIN: BIOGENESIS & PLASTICITY OF SPINE APPARATUS
    Peter Mundel; Fiscal Year: 2008
    ..This should in the long-term enable us to develop novel therapies that tackle learning deficiencies and memory loss by modulating the expression of synaptopodin thereby promoting the cellular plasticity of the dendritic spine apparatus. ..