elastin

Summary

Top Publications

  1. ncbi Transgenic expression of matrix metalloproteinase-9 causes adult-onset emphysema in mice associated with the loss of alveolar elastin
    Robert Foronjy
    Columbia University, New York, New York, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1149-57. 2008
  2. pmc Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease
    Ashwini Pai
    Department of Bioengineering, University of Washington, Seattle, Washington, USA
    Am J Pathol 178:764-73. 2011
  3. ncbi Assessment of atherosclerotic plaque burden with an elastin-specific magnetic resonance contrast agent
    Marcus R Makowski
    King s College London, Division of Imaging Sciences and Biomedical Engineering, British Heart Foundation BHF Centre of Excellence, London, UK
    Nat Med 17:383-8. 2011
  4. ncbi New evidence for a critical role of elastin in calcification of native heart valves: immunohistochemical and ultrastructural study with literature review
    Ida Perrotta
    Department of Ecology, University of Calabria, Rende, Cosenza, Italy
    Histopathology 59:504-13. 2011
  5. ncbi Evaluation of cell penetrating peptides fused to elastin-like polypeptide for drug delivery
    Iqbal Massodi
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    J Control Release 108:396-408. 2005
  6. ncbi Systemic elastin degradation in chronic obstructive pulmonary disease
    John D Maclay
    ELEGI Colt Laboratory, Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Thorax 67:606-12. 2012
  7. ncbi Elastin biosynthesis: The missing link in tissue-engineered blood vessels
    Alpesh Patel
    Department of Chemical and Biochemical Engineering, University of Western Ontario, London, ON, Canada
    Cardiovasc Res 71:40-9. 2006
  8. ncbi Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
    P Carmeliet
    Centre for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Nat Genet 17:439-44. 1997
  9. ncbi A critical role for elastin signaling in vascular morphogenesis and disease
    Satyajit K Karnik
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT, USA
    Development 130:411-23. 2003
  10. ncbi Proline and glycine control protein self-organization into elastomeric or amyloid fibrils
    Sarah Rauscher
    Molecular Structure and Function Programme, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Structure 14:1667-76. 2006

Detail Information

Publications329 found, 100 shown here

  1. ncbi Transgenic expression of matrix metalloproteinase-9 causes adult-onset emphysema in mice associated with the loss of alveolar elastin
    Robert Foronjy
    Columbia University, New York, New York, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1149-57. 2008
    ..significantly different between wild-type and transgenic mice, but MMP-9 did significantly decrease alveolar wall elastin at 1 yr of age (4.9+/-0.3% area of alveolar wall in the littermate mice vs. 3.3+/-0...
  2. pmc Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease
    Ashwini Pai
    Department of Bioengineering, University of Washington, Seattle, Washington, USA
    Am J Pathol 178:764-73. 2011
    ..b>Elastin turnover and vascular smooth muscle cell (VSMC) phenotype change were early events, detected by week 4 and before ..
  3. ncbi Assessment of atherosclerotic plaque burden with an elastin-specific magnetic resonance contrast agent
    Marcus R Makowski
    King s College London, Division of Imaging Sciences and Biomedical Engineering, British Heart Foundation BHF Centre of Excellence, London, UK
    Nat Med 17:383-8. 2011
    ..Here we introduce an elastin-specific magnetic resonance contrast agent (ESMA) for noninvasive quantification of plaque burden in a mouse ..
  4. ncbi New evidence for a critical role of elastin in calcification of native heart valves: immunohistochemical and ultrastructural study with literature review
    Ida Perrotta
    Department of Ecology, University of Calabria, Rende, Cosenza, Italy
    Histopathology 59:504-13. 2011
    ..The aim of this study was to determine whether the onset of native calcific aortic stenosis is associated primarily with matrix remodelling events, and particularly with elastin degradation.
  5. ncbi Evaluation of cell penetrating peptides fused to elastin-like polypeptide for drug delivery
    Iqbal Massodi
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    J Control Release 108:396-408. 2005
    ..In this study, the efficiency and mechanism of cellular uptake of the CPPs penetratin, Tat, and MTS fused to elastin-like polypeptides (CPP-ELP) were evaluated...
  6. ncbi Systemic elastin degradation in chronic obstructive pulmonary disease
    John D Maclay
    ELEGI Colt Laboratory, Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Thorax 67:606-12. 2012
    Development of emphysema and vascular stiffness in chronic obstructive pulmonary disease (COPD) may be due to a common mechanism of susceptibility to pulmonary and systemic elastin degradation.
  7. ncbi Elastin biosynthesis: The missing link in tissue-engineered blood vessels
    Alpesh Patel
    Department of Chemical and Biochemical Engineering, University of Western Ontario, London, ON, Canada
    Cardiovasc Res 71:40-9. 2006
    ..In elastic and muscular arteries, elastin is a critical structural and regulatory matrix protein and plays an important and dominant role by conferring ..
  8. ncbi Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
    P Carmeliet
    Centre for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Nat Genet 17:439-44. 1997
    ....
  9. ncbi A critical role for elastin signaling in vascular morphogenesis and disease
    Satyajit K Karnik
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT, USA
    Development 130:411-23. 2003
    ..Previously, we demonstrated that the disruption of the elastin matrix leads to defective arterial morphogenesis...
  10. ncbi Proline and glycine control protein self-organization into elastomeric or amyloid fibrils
    Sarah Rauscher
    Molecular Structure and Function Programme, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Structure 14:1667-76. 2006
    b>Elastin provides extensible tissues, including arteries and skin, with the propensity for elastic recoil, whereas amyloid fibrils are associated with tissue-degenerative diseases, such as Alzheimer's...
  11. pmc Cell penetrating elastin-like polypeptides for therapeutic peptide delivery
    Gene L Bidwell
    University of Mississippi Medical Center, Department of Biochemistry, Jackson, 39216, USA
    Adv Drug Deliv Rev 62:1486-96. 2010
    ..This review article summarizes the development of elastin-like polypeptide (ELP) as a potential carrier for thermally targeted delivery of therapeutic peptides (TP), and ..
  12. ncbi Genetically encoded synthesis of protein-based polymers with precisely specified molecular weight and sequence by recursive directional ligation: examples from the elastin-like polypeptide system
    Dan E Meyer
    Department of Biomedical Engineering, Box 90281, Duke University, Durham, North Carolina 27708 0281, USA
    Biomacromolecules 3:357-67. 2002
    ..We used this method to synthesize three different libraries of elastin-like polypeptides (ELPs); each library encodes a unique ELP sequence with systematically varied molecular weights...
  13. ncbi Platelet inhibition and endothelial cell adhesion on elastin-like polypeptide surface modified materials
    Patrick H Blit
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada
    Biomaterials 32:5790-800. 2011
    ..Materials surface modified with fluorinated surface modifiers, containing peptides inspired from elastin cross-linking domains, have been used for the cross-linking of elastin-like polypeptide 4 (ELP4) macromolecules ..
  14. pmc Expression and purification of recombinant proteins from Escherichia coli: Comparison of an elastin-like polypeptide fusion with an oligohistidine fusion
    Kimberly Trabbic-Carlson
    Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
    Protein Sci 13:3274-84. 2004
    Thermally responsive elastin like polypeptides (ELPs) can be used to purify proteins from Escherichia coli culture when proteins are expressed as a fusion with an ELP...
  15. ncbi Effects of Arg-Gly-Asp-modified elastin-like polypeptide on pseudoislet formation via up-regulation of cell adhesion molecules and extracellular matrix proteins
    Kyeong Min Lee
    Laboratory of Biochemistry and Cellular Engineering, Division of NanoBio Technology, Daegu Gyeongbuk Institute of Science and Technology, Daegu 711 873, South Korea
    Acta Biomater 9:5600-8. 2013
    ..An RGD-modified elastin-like polypeptide (RGD-ELP), TGPG[VGRGD(VGVPG)(6)](20)WPC, has been reported previously as a bioactive matrix...
  16. pmc In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide
    Andrew J Simnick
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    J Control Release 155:144-51. 2011
    ..To this end we utilized amphiphilic block copolymers, composed of a genetically engineered elastin-like polypeptide (ELP) that self-assemble into monodisperse spherical micelles...
  17. pmc Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying
    Yiquan Wu
    Center for Biologicallyh Inspired Materials and Material Systems, Department of Mechanical Engineering and Materials Science, Pratt School of Engineering, Duke University, Durham, NC 27708, USA
    Biomacromolecules 10:19-24. 2009
    ..These particles are composed from genetically engineered elastin-like polypeptides (ELPs), a biodegradable, biocompatible, and bioresponsive polymer...
  18. ncbi Elastin as a biomaterial for tissue engineering
    W F Daamen
    Department of Biochemistry 280, NCMLS, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Biomaterials 28:4378-98. 2007
    Biomaterials based upon elastin and elastin-derived molecules are increasingly investigated for their application in tissue engineering...
  19. ncbi In patients with pseudoxanthoma elasticum a thicker and more elastic carotid artery is associated with elastin fragmentation and proteoglycans accumulation
    Lilian Kornet
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Ultrasound Med Biol 30:1041-8. 2004
    ..Indeed, elastin fragmentation and increased calcium and proteoglycans content were present in the arteries of the two PXE ..
  20. ncbi Elastin changes during chronological and photo-ageing: the important role of lysozyme
    S Seite
    L Oreal Recherche, Clichy, France
    J Eur Acad Dermatol Venereol 20:980-7. 2006
    ..We aimed to investigate qualitative and quantitative changes of dermal elastin fibres during cutaneous chronological and photo-ageing and the involvement of lysozyme in these processes...
  21. ncbi Genetic synthesis and characterization of pH- and temperature-sensitive silk-elastinlike protein block copolymers
    Ashish Nagarsekar
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, USA
    J Biomed Mater Res 62:195-203. 2002
    ..and temperature-sensitive block copolymer containing repeating sequences from silk (Gly-Ala-Gly-Ala-Gly-Ser) and elastin (Gly-Val-Gly-Val-Pro) protein...
  22. ncbi Layer-by-layer assembly of chitosan and recombinant biopolymers into biomimetic coatings with multiple stimuli-responsive properties
    Rui R Costa
    3B s Research Group Biomaterials, Biodegradables and Biomimetics, University of Minho, Avepark, Zona Industrial da Gandra, São Cláudio do Barco, 4806 909 Caldas das Taipas, Guimaraes, Portugal
    Small 7:2640-9. 2011
    In this work, biomimetic smart thin coatings using chitosan and a recombinant elastin-like recombinamer (ELR) containing the cell attachment sequence arginine-glycine-(aspartic acid) (RGD) are fabricated through a layer-by-layer approach...
  23. pmc The elastin fiber system between and adjacent to collector channels in the human juxtacanalicular tissue
    Cheryl R Hann
    Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA
    Invest Ophthalmol Vis Sci 52:45-50. 2011
    To determine the composition and investigate the elastin fiber system in the juxtacanalicular tissue adjacent to and between collector channel orifices in normal human eyes.
  24. pmc Elastin in large artery stiffness and hypertension
    Jessica E Wagenseil
    Department of Biomedical Engineering, Saint Louis University, 3507 Lindell Blvd, St Louis, MO 63103, USA
    J Cardiovasc Transl Res 5:264-73. 2012
    ..The extracellular matrix components, specifically the mix of elastin and collagen in the vessel wall, determine the passive mechanical properties of the large arteries...
  25. ncbi Intracellular degradation of elastin by cathepsin K in skin fibroblasts--a possible role in photoaging
    Katerine A Codriansky
    Department of Dermatology, Boston University School of Medicine, Boston, MA, USA
    Photochem Photobiol 85:1356-63. 2009
    Solar elastosis is observed in the dermis of photoaged skin and is characterized by an accumulation of abnormal elastin in the extracellular space...
  26. ncbi Ageing of the conduit arteries
    S E Greenwald
    Pathology Group, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London
    J Pathol 211:157-72. 2007
    ..with age due to alterations in their morphology and the composition of the their major structural proteins, elastin and collagen...
  27. pmc Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain
    Guoyong Sun
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, United States
    J Control Release 155:218-26. 2011
    ..These particles are predominantly composed from diblock copolymers of elastin-like polypeptide (ELP)...
  28. ncbi The role of elastin peptides in modulating the immune response in aging and age-related diseases
    T Fulop
    Research Center on Aging, University of Sherbrooke, 1036, rue Belvedere Sud, Sherbrooke, QC, J1H 4C4, Canada
    Pathol Biol (Paris) 60:28-33. 2012
    ..as cytomegalovirus, from tumor antigens or from other sources such as the extracellular matrix, especially from elastin fibres and collagens...
  29. ncbi Mechanical failure, stress redistribution, elastase activity and binding site availability on elastin during the progression of emphysema
    Bela Suki
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Pulm Pharmacol Ther 25:268-75. 2012
    ..Next, we specifically discuss recent findings that stretching of elastin induces an increase in the binding off rate of elastase to elastin as well as unfolds hidden binding sites along ..
  30. ncbi A study on polymorphisms of elastin gene in Chinese Han patients with isolated systolic hypertension
    Liehua Deng
    Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China
    Am J Hypertens 22:656-62. 2009
    b>Elastin (ELN) is mainly located in the internal elastic lamina of large arteries. Degradation of ELN is expected to induce large vessel stiffness, which could lead to elderly systolic hypertension...
  31. pmc New insights into the pathogenesis of autosomal-dominant cutis laxa with report of five ELN mutations
    Bert Callewaert
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Hum Mutat 32:445-55. 2011
    ..Electron microscopy revealed elastic fiber fragmentation and diminished dermal elastin deposition. RT-PCR studies showed stable mutant mRNA in all patients...
  32. ncbi Structural determinants of cross-linking and hydrophobic domains for self-assembly of elastin-like polypeptides
    Ming Miao
    Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Biochemistry 44:14367-75. 2005
    b>Elastin is a major structural protein found in large blood vessels, lung, ligaments, and skin, imparting the physical properties of extensibility and elastic recoil to these tissues...
  33. pmc Tunable self-assembly of genetically engineered silk--elastin-like protein polymers
    Xiao Xia Xia
    Department of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155, United States
    Biomacromolecules 12:3844-50. 2011
    Silk--elastin-like protein polymers (SELPs), consisting of the repeating units of silk and elastin blocks, combine a set of outstanding physical and biological properties of silk and elastin...
  34. ncbi Differential expression of lysyl oxidases LOXL1 and LOX during growth and aging suggests specific roles in elastin and collagen fiber remodeling in rat aorta
    Jacques Behmoaras
    INSERM, U698, Hopital Bichat, Paris, Universite Paris 7, France
    Rejuvenation Res 11:883-9. 2008
    ..Lysyl oxidases catalyze a key step in the posttranslational cross-linking of elastin and collagens in the ECM...
  35. ncbi Association of elastin gene polymorphism to age-related macular degeneration and polypoidal choroidal vasculopathy
    Kenji Yamashiro
    Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 52:8780-4. 2011
    To see if there is an association in Japanese between elastin gene (ELN) polymorphisms and neovascular age-related macular degeneration (AMD) or its subtypes, typical AMD (tAMD) and polypoidal choroidal vasculopathy (PCV).
  36. ncbi Electrospinning collagen and elastin: preliminary vascular tissue engineering
    Eugene D Boland
    Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23298 0694, USA
    Front Biosci 9:1422-32. 2004
    ..have pioneered the electrospinning of micro- and nano-fibrous scaffoldings from the natural polymers collagen and elastin and applied these to development of biomimicking vascular tissue engineered constructs...
  37. ncbi Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages
    S D Shapiro
    Department of Medicine, Jewish Hospital, Washington University Medical Center, St Louis, Missouri 63110
    J Biol Chem 268:23824-9. 1993
    Human alveolar macrophages have the capacity to degrade elastin. As an approach to define proteinases responsible for this activity, we recently cloned a murine macrophage elastase cDNA and demonstrated that it is a member of the matrix ..
  38. ncbi The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis
    M E Curran
    Department of Human Genetics, University of Utah, Salt Lake City 84112
    Cell 73:159-68. 1993
    ..Pulsed-field gel and Southern analyses showed that a translocation near the elastin gene cosegregated with SVAS in one family...
  39. ncbi The role of elastin and collagen in cutaneous aging: intrinsic aging versus photoexposure
    Jouni Uitto
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Philadelphia, PA, USA
    J Drugs Dermatol 7:s12-6. 2008
    ..Using recombinant DNA technology, it has become possible to demonstrate that UV radiation can activate the human elastin promoter...
  40. pmc Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinases
    Dina M Basalyga
    Department of Bioengineering, Clemson University, Clemson, SC 29634, USA
    Circulation 110:3480-7. 2004
    b>Elastin calcification is a widespread feature of vascular pathology, and circumstantial evidence exists for a correlation between elastin degradation and calcification...
  41. ncbi Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody
    Doreen M Floss
    Leibniz Institute of Plant Genetics and Crop Plant Research IPK, Gatersleben, Germany
    Plant Biotechnol J 7:899-913. 2009
    ..Although antibodies are predominantly manufactured using mammalian cells, elastin-like peptide (ELP) fusion technology improves the stability of recombinant, plant-produced proteins and ..
  42. pmc Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves
    Steven R Lammers
    Mechanical Engineering, University of Colorado, Boulder, Colorado, USA
    Am J Physiol Heart Circ Physiol 295:H1451-9. 2008
    ..and metallomatrix proteins in affecting vascular stiffness, much less work has been performed on changes in elastin structure-function relationships in PAH...
  43. ncbi The elastin-binding protein of Staphylococcus aureus (EbpS) is expressed at the cell surface as an integral membrane protein and not as a cell wall-associated protein
    Robert Downer
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    J Biol Chem 277:243-50. 2002
    The elastin-binding proteins EbpS of Staphylococcus aureus strains Cowan and 8325-4 were predicted from sequence analysis to comprise 486 residues...
  44. ncbi Elastin
    Suzanne M Mithieux
    School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia
    Adv Protein Chem 70:437-61. 2005
    b>Elastin is a key extracellular matrix protein that is critical to the elasticity and resilience of many vertebrate tissues including large arteries, lung, ligament, tendon, skin, and elastic cartilage...
  45. ncbi Sequence and structure determinants for the self-aggregation of recombinant polypeptides modeled after human elastin
    Ming Miao
    Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 278:48553-62. 2003
    b>Elastin is a polymeric structural protein that imparts the physical properties of extensibility and elastic recoil to tissues...
  46. pmc Alterations in aortic cellular constituents during thoracic aortic aneurysm development: myofibroblast-mediated vascular remodeling
    Jeffrey A Jones
    Division of Cardiothoracic Surgery Research, Department of Surgery, Medical University of South Carolina, Strom Thurmond Research Building, 114 Doughty Street, Suite 625, Charleston, SC 29425, USA
    Am J Pathol 175:1746-56. 2009
    ..that changes in the resident endogenous cellular population accompany alterations in aortic collagen and elastin content during thoracic aortic aneurysm (TAA) development in a murine model...
  47. ncbi Basic components of connective tissues and extracellular matrix: elastin, fibrillin, fibulins, fibrinogen, fibronectin, laminin, tenascins and thrombospondins
    Jaroslava Halper
    Department of Pathology, College of Veterinary Medicine and Medical Partnership, The University of Georgia, Athens, GA, 30602 7388, USA
    Adv Exp Med Biol 802:31-47. 2014
    Collagens are the most abundant components of the extracellular matrix and many types of soft tissues. Elastin is another major component of certain soft tissues, such as arterial walls and ligaments...
  48. pmc Elastin sequences trigger transient proinflammatory responses by human dermal fibroblasts
    Jessica F Almine
    School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
    FASEB J 27:3455-65. 2013
    ..b>Elastin is enriched in the deep dermis of skin...
  49. ncbi Solid-state NMR evidence for elastin-like beta-turn structure in spider dragline silk
    Janelle E Jenkins
    Department of Chemistry and Biochemistry, Magnetic Resonance Research Center, Arizona State University, Tempe, AZ 85287, USA
    Chem Commun (Camb) 46:6714-6. 2010
    ..MAS NMR experiments on (13)C/(15)N-proline labeled Argiope aurantia dragline silk provide evidence for an elastin-like beta-turn structure for the repetitive Gly-Pro-Gly-X-X motif prevalent in major ampullate spidroin 2 (MaSp2).
  50. pmc Hydroxyapatite and calcified elastin induce osteoblast-like differentiation in rat aortic smooth muscle cells
    Yang Lei
    Department of Bioengineering, Clemson University, USA
    Exp Cell Res 323:198-208. 2014
    ..Intimal calcification related to atherosclerosis and elastin-specific medial arterial calcification (MAC)...
  51. pmc Interaction between the elastin peptide VGVAPG and human elastin binding protein
    Charlotte Blanchevoye
    Laboratoire de Signalisation et Récepteurs Matriciels, FRE CNRS 3184, Universite de Reims Champagne Ardenne, UFR Sciences Exactes et Naturelles, Moulin de la Housse, BP 1039, 51687 Reims Cedex 2, France
    J Biol Chem 288:1317-28. 2013
    The elastin binding protein (EBP), a spliced variant of lysosomal β-galactosidase, is the primary receptor of elastin peptides that have been linked to emphysema, aneurysm and cancer progression...
  52. ncbi Cellular response to nanoscale elastin-like polypeptide polyelectrolyte multilayers
    M Swierczewska
    Bioengineering and Life Sciences Program, Lehigh University, Bethlehem, PA 18015, USA
    Acta Biomater 4:827-37. 2008
    Ionic elastin-like polypeptide (ELP) conjugates are a new class of biocompatible, self-assembling biomaterials...
  53. pmc Applications of elastin-like polypeptides in tissue engineering
    Dana L Nettles
    Department of Biomedical Engineering, Durham, NC 27708, USA
    Adv Drug Deliv Rev 62:1479-85. 2010
    b>Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be ..
  54. ncbi Injury and repair in the very immature lung following brief mechanical ventilation
    Nadine Brew
    Department of Anatomy and Developmental Biology, Monash University, Victoria, Australia
    Am J Physiol Lung Cell Mol Physiol 301:L917-26. 2011
    ..At 1 day after MV, lungs displayed signs of injury, including hemorrhage, disorganized elastin and collagen deposition in the distal airspaces, altered morphology, significantly reduced secondary septal crest ..
  55. ncbi A three-layered electrospun matrix to mimic native arterial architecture using polycaprolactone, elastin, and collagen: a preliminary study
    Michael J McClure
    Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284 3067, USA
    Acta Biomater 6:2422-33. 2010
    Throughout native artery, collagen, and elastin play an important role, providing a mechanical backbone, preventing vessel rupture, and promoting recovery under pulsatile deformations...
  56. ncbi Doxycycline inhibits elastin degradation and reduces metalloproteinase activity in a model of aneurysmal disease
    J R Boyle
    Department of Surgery, Leicester University, United Kingdom
    J Vasc Surg 27:354-61. 1998
    Abdominal aortic aneurysms are characterized by degradation of the extracellular matrix, with a reduction in the elastin concentration of the arterial media...
  57. ncbi Structure of large arteries: orientation of elastin in rabbit aortic internal elastic lamina and in the elastic lamellae of aortic media
    Paul Farand
    Cardiology, Centre Hospitalier Universitaire de Sherbrooke CHUS Sherbrooke, QC, Canada
    Microvasc Res 73:95-9. 2007
    ..used to study the histomorphologic properties of the elastic fibers of rabbit aorta after purification of the elastin by means of hot alkaline treatments...
  58. pmc Right coronary artery becomes stiffer with increase in elastin and collagen in right ventricular hypertrophy
    Marisa Garcia
    Department of Biomedical Engineering, Surgery, Cellular and Integrative Physiology, Indiana University Purdue University, Indianapolis, IN 46202, USA
    J Appl Physiol (1985) 106:1338-46. 2009
    ..We hypothesized that an increase in RCA flow will lead to increased stiffness in conjunction with remodeling of elastin and collagen in the vessel wall. The control and experimental groups consisted of five RCA vessels each...
  59. ncbi Antielastin autoimmunity in tobacco smoking-induced emphysema
    Seung Hyo Lee
    Department of Medicine, Section of Pulmonary and Critical Care, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Med 13:567-9. 2007
    ..These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.
  60. pmc Morphological and extracellular matrix changes following vocal fold injury in mice
    Masaru Yamashita
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Cells Tissues Organs 192:262-71. 2010
    ..IHC was specific for procollagen type I, collagen type I, collagen type III, collagen type IV, elastin, decorin, fibronectin and hyaluronic acid binding protein 2...
  61. ncbi Immediate inflammatory response and scar formation in wounded vocal folds
    Xinhong Lim
    Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison, USA
    Ann Otol Rhinol Laryngol 115:921-9. 2006
    ..Thus, we examined the inflammation profile and extracellular matrix production in wounded vocal folds in the acute phase of wound healing...
  62. ncbi Elastin: mutational spectrum in supravalvular aortic stenosis
    K Metcalfe
    University Department of Medical Genetics and Regional Genetics Service, St Mary s Hospital, Manchester, UK
    Eur J Hum Genet 8:955-63. 2000
    ..SVAS is caused by translocations, gross deletions and point mutations that disrupt the elastin gene (ELN) on 7q11.23...
  63. pmc Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report
    Pei Zhang
    Department of Pharmacology, Yale University School of Medicine, Amistad Research Bldg, 10 Amistad St, New Haven, CT 06520, USA
    Arterioscler Thromb Vasc Biol 32:756-9. 2012
    The goal of this study was to determine whether antagonizing microRNA (miR)-29 enhances elastin (ELN) levels in cells and tissues lacking ELN.
  64. ncbi Degradation of elastin by a cysteine proteinase from Staphylococcus aureus
    J Potempa
    Institute of Molecular Biology, Jagiellonian University, Cracow, Poland
    J Biol Chem 263:2664-7. 1988
    ..enzymes, a cysteine proteinase, after purification to homogeneity was found to degrade insoluble bovine lung elastin at a rate comparable to human neutrophil elastase...
  65. ncbi Coenzyme Q(10) enhances dermal elastin expression, inhibits IL-1α production and melanin synthesis in vitro
    M Zhang
    The Space Biology Research and Technology Center, China Aerospace Science and Technology Corporation, Beijing, China
    Int J Cosmet Sci 34:273-9. 2012
    ..In addition, CoQ(10) treatment increased elastin gene expression in cultured fibroblasts and significantly decreased UVR-induced IL-1α production in HaCat cells...
  66. ncbi Modification of elastin by pentosidine is associated with the calcification of aortic media in patients with end-stage renal disease
    Noriyuki Sakata
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Nephrol Dial Transplant 18:1601-9. 2003
    ..The aim of this study was to clarify the role of glycoxidative modification of elastin in the calcification of aortic media in this group of patients.
  67. pmc Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency
    Gilles Faury
    Laboratoire de Développement et Vieillissement de l Endothélium, Commisarriat à l Energie Atomique Institut National de la Santé et de la Recherche Médicale Equipq Mixte 0219, Universite Joseph Fourier, Grenoble, France
    J Clin Invest 112:1419-28. 2003
    Supravalvular aortic stenosis is an autosomal-dominant disease of elastin (Eln) insufficiency caused by loss-of-function mutations or gene deletion...
  68. pmc Intravenous and intramyocardial injection of apoptotic white blood cell suspensions prevents ventricular remodelling by increasing elastin expression in cardiac scar tissue after myocardial infarction
    Michael Lichtenauer
    Department of Thoracic Surgery, Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University Vienna, Wahringer Gurtel 18 20, Vienna, Austria
    Basic Res Cardiol 106:645-55. 2011
    ..The higher expression of elastic fibres provides passive energy to the cardiac scar tissue and results in prevention of ventricular remodelling...
  69. ncbi Structural disorder and dynamics of elastin
    Lisa D Muiznieks
    Research Institute, Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada
    Biochem Cell Biol 88:239-50. 2010
    b>Elastin is a self-assembling, extracellular-matrix protein that is the major provider of tissue elasticity...
  70. ncbi The expression of cross-linked elastin by rabbit blood vessel smooth muscle cells cultured in polyhydroxyalkanoate scaffolds
    Shao Ting Cheng
    Multidisciplinary Research Center, Shantou University, Shantou 515063, Guangdong, China
    Biomaterials 29:4187-94. 2008
    ..P3HB4HB)s containing 0-40 mol% 4-hydroxybutyrate (4HB) were studied for growth and formation of elastin of rabbit blood vessel smooth muscle cells (RaSMCs) incubated on the solvent-casting polyester films...
  71. ncbi Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of eplerenone
    Patrick Lacolley
    INSERM EMI U0107, Paris, France
    Circulation 106:2848-53. 2002
    ..Our aim was to determine the effects of Aldo and the Aldo receptor antagonist eplerenone (Epl) on in vivo mechanical properties of the carotid artery using echo-tracking system...
  72. ncbi Elastin rs2301995 polymorphism is not associated with polypoidal choroidal vasculopathy in caucasians
    Luiz H Lima
    Vitreous, Retina, Macula Consultants of New York and the LuEsther T Mertz Retina Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, USA
    Ophthalmic Genet 32:80-2. 2011
    To investigate the association of the rs2301995 haplotype-tagging single nucleotide polymorphism (htSNP) in the elastin gene (ELN) with polypoidal choroidal vasculopathy (PCV) in European-American patients.
  73. ncbi Sequences and domain structures of mammalian, avian, amphibian and teleost tropoelastins: Clues to the evolutionary history of elastins
    Martin I S Chung
    Cardiovascular Research Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada M5G1X8
    Matrix Biol 25:492-504. 2006
    Tropoelastin is the monomeric form of elastin, a polymeric extracellular matrix protein responsible for properties of extensibility and elastic recoil in connective tissues of most vertebrates...
  74. ncbi Elastin is an essential determinant of arterial morphogenesis
    D Y Li
    Cardiology Division, University of Utah Health Sciences Center, Salt Lake City 84112, USA
    Nature 393:276-80. 1998
    b>Elastin, the main component of the extracellular matrix of arteries, was thought to have a purely structural role...
  75. ncbi An elastin gene mutation producing abnormal tropoelastin and abnormal elastic fibres in a patient with autosomal dominant cutis laxa
    M Tassabehji
    University Department of Medical Genetics and Regional Genetics Service, St Mary s Hospital, Manchester M13 0JH, UK
    Hum Mol Genet 7:1021-8. 1998
    b>Elastin is the protein responsible for the characteristic elastic properties of many tissues including the skin, lungs and large blood vessels...
  76. ncbi Matrix metalloproteinase-12 leads to elastin degradation in BALB/c mice with eosinophilic meningitis caused by Angiostrongylus cantonensis
    P C Wei
    Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Int J Parasitol 41:1175-83. 2011
    ..The purpose of this study was to determine whether matrix metalloproteinase (MMP)-12 and its substrate elastin participate in this inflammatory response...
  77. pmc Blood flow interplays with elastin: collagen and MMP: TIMP ratios to maintain healthy vascular structure and function
    Poulami Basu
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Vasc Health Risk Manag 6:215-28. 2010
    ..There was a higher degree of basement membrane collagen in the femoral artery and therefore a low elastin: collagen ratio, while in the carotid artery a higher level of elastin and, therefore, a high elastin: collagen ..
  78. pmc Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2
    Aleksander Hinek
    Department of Laboratory Medicine and Pathobiology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Am J Pathol 173:1042-56. 2008
    We recently established that the elastin-binding protein, which is identical to the spliced variant of beta-galactosidase, forms a cell surface-targeted complex with two proteins considered "classic lysosomal enzymes": protective protein/..
  79. ncbi Mechanism of formation of elastin crosslinks
    M Akagawa
    Department of Applied Bioorganic Chemistry, Division of Life Science, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 8555, Japan
    Connect Tissue Res 41:131-41. 2000
    We examined the formation of quaternary pyridinium crosslinks of elastin formed by condensation of lysine and allysine residues using the model compounds propanal (allysine) and n-butylamine (lysine) under quasi-physiological conditions...
  80. ncbi Recombinant human elastin polypeptides self-assemble into biomaterials with elastin-like properties
    Catherine M Bellingham
    Cardiovascular Research Program, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5E 1X8
    Biopolymers 70:445-55. 2003
    ..One biological example of a protein polymer with potential for self-organization is elastin. Elastin is the extracellular matrix protein that imparts the properties of extensibility and elastic recoil to ..
  81. ncbi A model two-component system for studying the architecture of elastin assembly in vitro
    Suzanne M Mithieux
    School of Molecular Biosciences, University of Sydney, NSW 2006, Australia
    J Struct Biol 149:282-9. 2005
    ..The oxidized human tropoelastin forms an elastin-like polymer (EL) that is elastic, shows hydrogel behavior and contains typical elastin cross-links including ..
  82. ncbi Silk-elastinlike protein polymers for matrix-mediated cancer gene therapy
    Joshua A Gustafson
    Department of Bioengineering, University of Utah, Salt Lake City, USA
    Adv Drug Deliv Rev 62:1509-23. 2010
    Silk-elastinlike protein polymers (SELPs) are recombinant polymers designed from silk fibroin and mammalian elastin amino acid repeats...
  83. ncbi Microstructural and tensile properties of elastin-based polypeptides crosslinked with genipin and pyrroloquinoline quinone
    S Vieth
    School of Chemical Engineering, Ryerson University, Toronto, Ontario, Canada
    Biopolymers 85:199-206. 2007
    b>Elastin is an elastomeric, self-assembling extracellular matrix protein with potential for use in biomaterials applications...
  84. ncbi Aging, carotid artery distensibility, and the Ser422Gly elastin gene polymorphism in humans
    O Hanon
    Department of Internal Medicine and INSERM U337, Hopital Broussais, Hopital Europeen Georges Pompidou, Paris, France
    Hypertension 38:1185-9. 2001
    b>Elastin is a protein of the extracellular matrix that forms the major component of elastic fibers from the arterial wall thickness and plays an important role in elastic properties of large blood vessels...
  85. pmc Connection between elastin haploinsufficiency and increased cell proliferation in patients with supravalvular aortic stenosis and Williams-Beuren syndrome
    Zsolt Urban
    Pacific Biomedical Research Center, University of Hawaii, Honolulu, USA
    Am J Hum Genet 71:30-44. 2002
    To elucidate the pathomechanism leading to obstructive vascular disease in patients with elastin deficiency, we compared both elastogenesis and proliferation rate of cultured aortic smooth-muscle cells (SMCs) and skin fibroblasts from ..
  86. ncbi Recombinant silk-elastinlike protein polymer displays elasticity comparable to elastin
    Weibing Teng
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona 85721, USA
    Biomacromolecules 10:3028-36. 2009
    ..stress-strain analysis, methanol-treated non-cross-linked SELP-47K films exceeded the properties of native aortic elastin, attaining an ultimate tensile strength of 2.5 +/- 0.4 MPa, an elastic modulus of 1.7 +/- 0...
  87. ncbi Possible involvement of increased glycoxidation and lipid peroxidation of elastin in atherogenesis in haemodialysis patients
    Yuji Yamamoto
    Second Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Nephrol Dial Transplant 17:630-6. 2002
    ..purpose of this study was to test the hypothesis that increased glycoxidation and lipid peroxidation of aortic elastin is implicated in the cardiovascular complications, particularly atherosclerosis, of chronic haemodialysis patients...
  88. ncbi Kinetics and morphology of self-assembly of an elastin-like polypeptide based on the alternating domain arrangement of human tropoelastin
    Judith T Cirulis
    Molecular Structure and Function Program, Research Institute, The Hospital for Sick Children, and Department of Biochemistry, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada M5G1X8
    Biochemistry 49:5726-33. 2010
    b>Elastin is the polymeric extracellular matrix protein responsible for the properties of extensibility and elastic recoil in tissues such as arterial blood vessels, lung parenchyma, and skin...
  89. ncbi Molecular engineering of silk-elastinlike polymers for matrix-mediated gene delivery: biosynthesis and characterization
    Mohamed Haider
    Department of Pharmaceutical Sciences, Greenebaum Cancer Center, University of Maryland, 20 North Penn Street, Baltimore, MD 21201, USA
    Mol Pharm 2:139-50. 2005
    ..and characterization of a series of new silk-elastinlike protein polymers (SELPs), namely, SELP415K, with larger elastin blocks per monomer unit than SELP47K previously studied for matrix-mediated gene delivery...
  90. ncbi Comparative genomics of elastin: Sequence analysis of a highly repetitive protein
    David He
    Program in Molecular Structure and Function, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario Canada M5G 1X8
    Matrix Biol 26:524-40. 2007
    ..their sequences, uncovering the evolutionary and functional relationships in highly repetitive proteins such as elastin, spider silks, resilin and abductin represents a significant challenge...
  91. pmc The effect of secondhand smoke exposure on markers of elastin degradation
    Natalie Slowik
    Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10019, USA
    Chest 140:946-53. 2011
    ..Secondhand smoke (SHS) exposure is a known risk factor in asthma, bronchitis, and coronary artery disease. Elastin is a recognized target for injury in COPD, and the amino acids desmosine and isodesmosine (D/I), which are ..
  92. ncbi Elastin-derived peptides induce a T-helper type 1 polarization of human blood lymphocytes
    Romain Debret
    Laboratoire d Immunologie, Virologie et Bactériologie, Reims, France
    Arterioscler Thromb Vasc Biol 25:1353-8. 2005
    Increased level of elastin-derived peptides (EDPs) is observed in the serum of patients with manifestations of arterial diseases...
  93. pmc Tissue elasticity and the ageing elastic fibre
    Michael J Sherratt
    Tissue Injury and Repair Group, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK
    Age (Dordr) 31:305-25. 2009
    ..Elastic fibres are composite structures composed of a cross-linked elastin core and an outer layer of fibrillin microfibrils...
  94. pmc Elastin fragments drive disease progression in a murine model of emphysema
    A McGarry Houghton
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 116:753-9. 2006
    ..Fractionation of the bronchoalveolar lavage fluid demonstrated the presence of elastin fragments only in the fractions containing chemotactic activity...
  95. ncbi Transplantation of elastin-secreting myoblast sheets improves cardiac function in infarcted rat heart
    Ayako Uchinaka
    Department of Molecular Pathology, Osaka University Graduate School of Medicine, Division of Health Sciences, 1 7 Yamada oka, Suita, Osaka 565 0871, Japan
    Mol Cell Biochem 368:203-14. 2012
    ..b>Elastin fiber enhances the extensibility of the infarcted wall and can prevent left ventricular dilation...
  96. pmc Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice
    Galina K Sukhova
    the Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 111:897-906. 2003
    ..CatS(-/-)LDLR(-/-) monocytes showed impaired subendothelial basement membrane transmigration, and aortas from CatS(-/-)LDLR(-/-) mice had preserved elastic laminae. These findings establish a pivotal role for Cat S in atherogenesis...
  97. ncbi Wet-spinning of recombinant silk-elastin-like protein polymer fibers with high tensile strength and high deformability
    Weiguo Qiu
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona 85721, USA
    Biomacromolecules 10:602-8. 2009
    A recombinant silk-elastin-like protein copolymer SELP-47K containing tandemly repeated amino acid sequence blocks from silk, GAGAGS, and elastin, GVGVP, was fabricated into microdiameter fibers using a wet-spinning technique...
  98. pmc Elastin-mediated choroidal endothelial cell migration: possible role in age-related macular degeneration
    Jessica M Skeie
    Center for Macular Degeneration, Department of Ophthalmology and Visual Science, University of Iowa, Iowa City, Iowa 52242, USA
    Invest Ophthalmol Vis Sci 49:5574-80. 2008
    ..Altered elastin metabolism has been described in AMD, and the present study sought to determine the effects of elastin-derived ..
  99. ncbi The effect of TGF-beta2 on elastin, type VI collagen, and components of the proteolytic degradation system in human optic nerve astrocytes
    Carolin Neumann
    Department of Anatomy II, Friedrich Alexander University, Erlangen, Germany
    Invest Ophthalmol Vis Sci 49:1464-72. 2008
    To investigate the effect of transforming growth factor (TGF)-beta2 on the expression of (1) elastin and type VI collagen (ColVI), (2) extracellular matrix (ECM)-degrading matrix-metalloproteinases (MMPs) and regulators of their activity/..
  100. ncbi Elastin-like polypeptides revolutionize recombinant protein expression and their biomedical application
    Doreen M Floss
    Institute of Biochemistry, Christian Albrechts University, Olshausenstrasse 40, D 24098 Kiel, Germany
    Trends Biotechnol 28:37-45. 2010
    b>Elastin-like polypeptides (ELPs) are highly biocompatible and exhibit a potentially highly useful property: that of a thermally responsive reversible phase transition...
  101. ncbi Long-term evaluation of collagen and elastin following infrared (1100 to 1800 nm) irradiation
    Yohei Tanaka
    Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, Matsumoto, Japan
    J Drugs Dermatol 8:708-12. 2009
    Infrared irradiation stimulates collagen production, but histological differences in its long-term effects on type I versus type III collagen and elastin in human tissue are unclear.

Research Grants72

  1. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2013
    ..g., collagen, elastin and histone H1, essential for organization and stabilization of the extracellular matrix (ECM) and the cell ..
  2. Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
    Farrah Kheradmand; Fiscal Year: 2012
    ..COPD is characterized by destruction of lung matrix, especially elastin, resulting in loss of elastic recoil, air trapping and lung hyperinflation...
  3. Stem Cell Homing for Treatment of Female Pelvic Floor Disorders
    Margot S Damaser; Fiscal Year: 2013
    ..Lysyl oxidase-like 1 (LOXL1) is a protein essential for elastin remodeling and homeostasis...
  4. Targeting AP-1 proteins in COPD
    SEKHAR M POTHIREDDY; Fiscal Year: 2010
    ..Fra-1 has also been shown to regulate transrepression of the elastin gene transcription that is promoted by growth factors secreted from by extracellular matrix in response to ..
  5. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..Biochemical and experimental studies have also implicated reactive oxygen species in modifications of elastin and collagen that would promote arterial stiffening...
  6. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..The immediate cause of emphysema is destruction of lung matrix, especially elastin, resulting in loss of elastic recoil, dynamic airway collapse during exhalation, air trapping and lung ..
  7. Fate of Lung Stem Cells During Pulmonary Disease
    Susan M Majka; Fiscal Year: 2012
    ..Myofibroblasts were characterized by collagen/elastin synthesis...
  8. Aldosterone, Autophagy, and Arterial Stiffness
    Jane A Leopold; Fiscal Year: 2013
    ..by vascular smooth muscle cell disarray, increased deposition of aberrant collagen and fragmentation of elastin, all of which contribute to decrease a functional decrease in vascular compliance...
  9. Therapeutic use of small-molecule HGF-mimetic for emphysema
    BERT J W M OEHLEN; Fiscal Year: 2010
    ..Such activities include promotion of elastin synthesis, suppression of apoptosis, suppression of inflammation, induction of angiogenesis and stimulation of ..
  10. Role of Inflammation in the Pathobiology of Abdominal Aortic Aneurysm
    KATHLEEN RAMAN; Fiscal Year: 2013
    ..Aortic wall inflammation results in two fundamental structural changes which underlie AAA;elastin degradation and loss of smooth muscle cells (SMC) within the aortic media...
  11. Molecular Mechanism of Arterial Stiffening
    Zhongjie Sun; Fiscal Year: 2013
    ..MMP-9, TGF-21, and runt-related transcription factor-2 (RUNX-2) in SMCs and their relationship in KL-KO- induced elastin degradation, osteoblastic transition, calcification (elastocalcinosis), and arterial stiffening and systolic ..
  12. Angiotensin II uncoupling of eNOS in hypertension
    HUA LINDA CAI; Fiscal Year: 2013
    ..further uncoupling of eNOS, and consequent vascular remodeling highlighted by inflammation and MMP-mediated elastin and collagen degradation;3) Recoupling of eNOS is highly effective in preventing AAA formation in Ang II-infused ..
  13. The Biomechanics of the Human Posterior Sclera: Effects of Age, Sex, and Glaucoma
    Thao D Nguyen; Fiscal Year: 2013
    ..The goals of the proposal are to (1) measure the regionally varying thickness, anisotropy of the collagen and elastin structure, the inflation response to IOP fluctuations, and viscoelastic properties of the posterior human sclera, ..
  14. 2013 Elastin, Elastic Fibers &Microfibrils Gordon Research Conference &Gordon R
    Zsolt Urban; Fiscal Year: 2013
    ..We propose to organize and support the 2013 Gordon Research Seminar (GRS) and Gordon Research Conference (GRC) on Elastin, Elastic Fibers &Microfibrils to be held in conjunction from July 20th - 21st (GRS) and July 21st - 26th (GRC)..
  15. Mechanisms Underlying the Progression of Arterial Stiffness in Hypertension
    Jay D Humphrey; Fiscal Year: 2013
    ..that likely progresses over time from proximal to distal arteries because of initial spatial distributions of elastin and associated wall strains...
  16. Atomic Force Microscopic Studies of Dissecting Aneurysm
    Paul J Boor; Fiscal Year: 2013
    ..addressed by two Specific Aims: First, physical defects in the aorta's major structural proteins (collagen;elastin) will be defined after in vivo or in vitro AEE exposure...
  17. KLF15 in vascular disease
    MUKESH KUMAR JAIN; Fiscal Year: 2013
    ..Mice deficient in KLF15 develop AA characterized by elastin fragmentation, vascular inflammation/dissection, and SMC apoptosis following Ang II infusion...
  18. MECHANICAL STIMULATION OF IVD CELLS
    Lori A Setton; Fiscal Year: 2013
    ..We have experience with injectable and in situ forming elastin-like polypeptide (ELP) depots that provide for sustained local drug release...
  19. Role of the Giant Protein Titin in Skeletal Muscle Structure and Function
    Henk L Granzier; Fiscal Year: 2013
    ..induced hypertrophy and disuse-induced atrophy, relative to the changes in the extracellular matrix (collagen and elastin)...
  20. Transglutaminase 2 S-Nitrosylation: Role in Age-Related Vascular Stiffness
    Dan E Berkowitz; Fiscal Year: 2013
    ..fracturing of elastin) have been described in aging, molecular mechanisms underlying age-related vascular stiffness remain poorly ..
  21. Loss of Matrix Regulation and Aortic Aneurysm Development in vivo
    Hiromi Yanagisawa; Fiscal Year: 2013
    ..Fbln4SMKO aortae develop abnormal elastin and collagen fibers and a focal thickening of the aortic wall with proliferation of SMCs, downregulation of ..
  22. Extracellular Matrix Metabolism in Thoracic Aortic Aneurysm and Dissection
    Scott A LeMaire; Fiscal Year: 2011
    ..We will examine qualitatively and quantitatively the collagen and elastin, enzymes involved in collagen and elastin synthesis and secretion, and degradation in aortic samples of TAAD ..
  23. Cues for cell-mediated regeneration of elastin matrix in aortic aneurysms
    Anand Ramamurthi; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Abdominal aortic aneurysms (AAAs), characterized by degrading aortic elastin matrix and resultant vessel weakening and rupture, causes 15,000 deaths in the United States anually, primarily amongst ..
  24. Enabling Strategies for Growing Collagenous Tissues
    LAURA E contact NIKLASON; Fiscal Year: 2010
    ..In some connective tissues, such as skin and blood vessel, extracellular elastin also contributes recoil in response to tensile strain...
  25. CCN3 and aortic aneurysm
    Zhiyong Lin; Fiscal Year: 2013
    ..Mice systemically deficient in CCN3 develop AA characterized by elastin fragmentation, vascular inflammation/dissection, and SMC apoptosis following Ang II infusion...
  26. Tissue Engineering of a Neotrachea
    James E Dennis; Fiscal Year: 2013
    ..methods including staining for glycosaminoglycans, and immunohistochemistry for collagens type I, II, and X, and elastin, examined, histologically, for structure, tissue integration, epithelialization, and are evaluated for ..
  27. Induction of uterine vascular remodeling by myometrial stretch
    George J Osol; Fiscal Year: 2013
    ..in terms of both cellular (endothelial, vascular smooth muscle - VSM) and matrix (MMP/TIMPs;collagen and elastin content) changes, will then test the hypothesis that the process of arterial and venous expansive growth is ..
  28. Mechanisms of Mitochondrial Dysfunction in Brain Vasculature
    Neetu Tyagi; Fiscal Year: 2013
    ..Aim #2: To determine whether the homocysteinylation of cytochrome-c activates mt-MMP-9, disruption of collagen/elastin ratio, mtCxn43 and mt-tight junction proteins in ischemia reperfusion and if THC, CSE and SAHH shRNA gene therapy ..
  29. Th1 and Th17 Mediators in Experimental Emphysema
    Farrah Kheradmand; Fiscal Year: 2013
    ..that a subtype of smokers who develop emphysema harbor autoimmune inflammation, characterized by the presence of elastin- specific T helper type 1 (Th1) and Th17 cells...
  30. Protease Operated Depot for Delivery of GLP-1
    Ashutosh Chilkoti; Fiscal Year: 2013
    ..Our design of PODs is implemented by the fusion between a thermally sensitive elastin-like polypeptide (ELP) that is soluble at room temperature but forms a viscous coacervate depot upon injection at ..
  31. Neuromechanical basis of baroreceptor function
    John H Schild; Fiscal Year: 2010
    ..relationships associated with BR afferents relative to the basement membrane about the terminal ending, the elastin and collagen fibers within the surrounding tissue matrix as well as the neuro-integrative processes of ..
  32. Exosites in Matrix Metalloproteinase Localization and Activity
    Steven R Van Doren; Fiscal Year: 2013
    ..MMP-12 was located on the surface of activated macrophages from inflamed lungs and embedded in the elastin fibrils being digested in aneurysms forming in the aorta...
  33. Endothelial Myocyte Matrix in Cardiac Remodeling
    Suresh C Tyagi; Fiscal Year: 2013
    ..2: To determine whether chronic LV volume overload causes cardiac fibrosis by increasing collagen/elastin ratio, MMP-2, -9, -13, TIMP-1, -3, decreasing TIMP-4, and inducing PAR-1, and H2S mitigates cardiac fibrosis...
  34. ROS Mechanisms in BAV Aortopathy
    THOMAS GILLETTE GLEASON; Fiscal Year: 2013
    ..be achieved using multi-photon microscopy with second harmonic generation to define alignment of collagen and elastin fibers, histological detection of collagen and elastin, and quantification of MMP activity...
  35. The Role of LOX/LOXL Family Members in Abdominal Aortic Aneurysms (AAA)
    EBONY WASHINGTON; Fiscal Year: 2010
    ..Normally, these layers secrete structural proteins, such as collagen and elastin, into the extracellular matrix (ECM) for crosslinking and vessel integrity...
  36. The Effects of KLF4 in experimental aortic aneurysm formation
    Gorav Ailawadi; Fiscal Year: 2013
    ..MMP) production by macrophages and smooth muscle cells (SMCs) leading to destruction of collagen and elastin in the aortic wall and vessel dilation...
  37. Human tissue-engineered blood vessels using induced pluripotent stem cells
    Yibing Qyang; Fiscal Year: 2013
    ..TEBVs typically lack elastin (ELN), which is essential to mechanical properties of blood vessels, providing recoil and resistance to aneurysm ..
  38. Extracelluar Matrix Organization and Biomechanics of the Lamina Cribrosa and Peri
    JONATHAN PIETER VANDE GEEST; Fiscal Year: 2013
    ..The MOMD excites the second harmonic generation of collagen and the two-photon emitted fluorescence of elastin while simultaneously exposing posterior ocular tissues to either planar biaxial or pressure-inflation loads...
  39. Maternal Smoking and the Developing Lung
    Kathleen J Haley; Fiscal Year: 2010
    ..maternal smoking demonstrates significant alveolarization abnormalities, including fewer alveoli and decreased elastin expression...
  40. Scalable Units for Building Vascularized Cardiac Graft
    Lisa E Freed; Fiscal Year: 2013
    ..In Aim 1, we will create elastomeric scaffolds from poly (glycerol-sebacate) and elastin, and test the hypothesis that scaffold structural features (i.e...
  41. Gender Differences in Experimental Aortic Aneurysms
    GILBERT RIVERS UPCHURCH; Fiscal Year: 2012
    ..by early chemokine driven leukocyte infiltration into the aortic wall with subsequent destruction of elastin and collagen in the media and adventitia by excessive local production of matrix degrading enzymes, and smooth ..
  42. Host Defense Mechanisms in Chronic Lung Disease
    Jo Rae Wright; Fiscal Year: 2010
    ..host response, and subsequent airway remodeling via fibroblast proliferation, collagen expression and decreased elastin expression...
  43. Carbon Black Induced Activation of Lung APCs
    DAVID BRIAN CORRY; Fiscal Year: 2013
    ..lung destruction in emphysema by inducing the secretion of matrix metalloproteinase (MMP) 12 that degrades elastin and inhibits alpha 1 anti-trypsin, an inhibitor of neutrophil elastase...
  44. Elastogenic Factor Functionalized Electrospun Scaffolds for in vivo Generation of
    CHRISTOPHER A BASHUR; Fiscal Year: 2013
    ..fail to incorporate the biological and architectural components of vascular matrix due to inherently poor elastin synthesis by post-neonatal cells...
  45. PATHOGENESIS OF DISEASE IN MUCOPOLYSACCHARIDOSIS I AND VII
    Katherine P Ponder; Fiscal Year: 2010
    ..Aortas undergo elastin fragmentation and progressive dilatation, which can result in cardiovascular insufficiency and require surgery...
  46. Elafin Therapy for Lung Diseases
    Marlene Rabinovitch; Fiscal Year: 2013
    ..In all three projects, biomarkers of elastin degradation are investigated as a tool to judge elafin responsiveness...
  47. Genetic Epidemiology of Pelvic Organ Prolapse
    Jennifer Marie Wu; Fiscal Year: 2010
    ..Hypotheses regarding the pathophysiology of prolapse include abnormalities in collagen and elastin, as well as alterations in smooth and skeletal muscles...
  48. Molecular Determinants of Arterial Remodeling in Atherogenesis
    Peter Libby; Fiscal Year: 2013
    ..We will also image and characterize the structure of elastin in arterial tissue from these manipulated mutant mice...
  49. Mutations in Smooth Muscle Contractile Proteins: Pathways to Vascular Diseases
    Dianna M Milewicz; Fiscal Year: 2013
    Vascular SMCs are arranged circumferentially in arteries in multiple layers, either embedded between layers of elastin lamellae in large elastic arteries or in a matrix of connective tissue in smaller muscular arteries...
  50. TGF-beta, matrix, and myofibroblasts in hepatic fibrosis
    Rebecca G Wells; Fiscal Year: 2013
    ..will be achieved through three specific aims: Specific Aim #1: Determine the role of LOX-mediated collagen and elastin cross-linking in early fibrosis, in particular the functional mechanical consequences of the LOXs and the ..
  51. Engineering vascular replacements for strength and elasticity
    Thomas N Wight; Fiscal Year: 2013
    ..promise, but is problematic in two key areas, which will be addressed in this application: 1) the absence of elastin and 2) excessive maturation times in vitro...
  52. The Role of LOX and LOXL1 in the Pathophysiology of Endometriosis
    PERLA MARIA BAEZ; Fiscal Year: 2010
    ..oxidases are a family of extracellular amine oxidases, which mediate the formation of insoluble collagen and elastin in the extracellular matrix...
  53. Design and Assessment of a Compliant Nanofibrous Vascular Graft
    Kelvin G M Brockbank; Fiscal Year: 2011
    ..non-linear 'J-shaped'stress-strain biomechanical behavior which is a function of extracellular matrix elastin and collagen nanofibers...
  54. Pulmonary Hypertension in Genetically Modified Mice
    Marlene Rabinovitch; Fiscal Year: 2013
    ..ground breaking findings that impaired BMPRII signaling can lead to abnormal synthesis and assembly of elastin fibers in the walls of pulmonary arteries (PA)...
  55. Biomechanical Factors in Congenital Vascular Disease
    JESSICA WAGENSEIL; Fiscal Year: 2013
    ..Three mouse models with reduced arterial elasticity caused by knockouts of different proteins, elastin (Eln), fibulin-4 (Fbln4) and lysyl oxidase (Lox) will be used...
  56. 2011 Elastin and Elastic Fibers GRS GRC
    Richard A Pierce; Fiscal Year: 2011
    ..applicant): We propose to organize and support the 2011 Gordon Research Conference and Gordon Research Seminar on Elastin and Elastic Fibers to be held July 23-29, 2011 at the University of New England in Biddeford, Maine...
  57. NMR studies of the effects of mode of birth on vaginal elastin
    Gregory Boutis; Fiscal Year: 2013
    ..b>Elastin, the principle protein component of the elastic fiber, imparts vertebrate tissues such as the heart, lungs and ..
  58. ARFI ultrasound for noninvasive, Diagnostic atherosclerosis imaging
    Caterina M Gallippi; Fiscal Year: 2013
    ..show that in vivo ARFI imaging detected occlusive and nonocclusive plaques and described plaque collagen and elastin composition, which are material features relevant to predicting plaque risk (Behler et al 2006), (Behler et al ..
  59. Myocardial Stiffness in Diastolic Heart Failure
    Kenneth S Campbell; Fiscal Year: 2012
    ..continue to cycle during diastole) and a 'passive'stiffness component (attributed to titin, collagen, elastin and intermediate filaments)...
  60. FGF and PDGF regulate myofibroblast differentiation in alveolar regeneration
    ANNE KARINA THERESIA PERL; Fiscal Year: 2013
    ..In Aim 3 we will define the role of FGF and PDGF signaling on elastin synthesis in the differentiating myofibroblast...
  61. Disorganization of Elastin Matrix Mediates Erectile Dysfunction
    KANCHAN CHITALEY SCHINDLAUER; Fiscal Year: 2013
    ..mice have may impairment in tissue distensability resulting from altered deposition of fibrillar collagen and elastin. Elastic fibers are assembled extracellularly and are comprised of elastin and specific microfibrillar proteins...
  62. ARTERIAL PROPERTIES FROM STIMULATED ACOUSTICAL EMISSION
    JAMES FOWLER GREENLEAF; Fiscal Year: 2012
    ..In addition, the dependence of the material properties on various constituents of the artery such as elastin and collagen will be determined...
  63. Novel Corneal Implant Materials
    Shiao Chang; Fiscal Year: 2006
    ..The onlay material contains cell attachment domains derived from elastin and fibronectin, which provide mechanical stability and promote epithelial attachment...
  64. Endovascular device and treatment for stabilizing aortic aneurysms
    MATTHEW FRANK OGLE; Fiscal Year: 2010
    ..and progression of AAAs are associated with enzymatic degradation of extracellular matrix components such as elastin. Phenolic tannins, such as penta-galloylglucose (PGG), bind to vascular elastin, and in doing so, render elastin ..
  65. BIOLOGICAL ROLE OF LYSYL OXIDASE-2 IN MATRIX DEVELOPMENT
    Ian Hornstra; Fiscal Year: 1999
    ..Cambrian explosion (550 million years ago), having, subserved the unique function of cross-linking collagen and elastin in the presence of molecular oxygen, producing the strong and flexible ligaments and tendons of large animal ..
  66. 1999 GORDON CONFERENCE ON ELASTIN AND ELASTIN TISSUES
    Francesco Ramirez; Fiscal Year: 1999
    ..They are composed of two morphologically distinct components, elastin and microfibrils...
  67. REGULATION OF PULMONARY ELASTIN PRODUCTION BY RETINOIDS
    Stephen McGowan; Fiscal Year: 2000
    ..bronchiectasis can irreversibly alter the elastic properties of the lung by degradation of the structural protein elastin. Since virtually all of the elastin in the normal lung is produced during early like, studying the factors which ..
  68. CHEMISTRY AND BIOLOGY OF THE ELASTIN GENE
    JEFFREY DAVIDSON; Fiscal Year: 1999
    b>Elastin is the resilient protein of connective tissue, formed from a soluble, hydrophobic precursor and extensively crosslinked to provide remarkable durability...
  69. Growth Factor Treatment for Aged Vocal Folds
    Bernard Rousseau; Fiscal Year: 2010
    ..becomes less efficient, resulting in both qualitative and quantitative changes in the deposition of collagen and elastin within the aged vocal fold...
  70. Microsystem-based Formation of Recombinant Protein Fibers
    Xiaoyi Wu; Fiscal Year: 2010
    ..Specifically, recombinant silk-elastin-like proteins (SELPs) comprised of polypeptide sequences derived from silk and elastin will be used as a model ..
  71. Dental Nanocomposite Materials Using Functional Polymer and HAP Nanocrystals
    Seung Wuk Lee; Fiscal Year: 2009
    ..b>Elastin polymers conjugated with hydroxyapatite (HAP) specific peptides will be synthesized using bacterial biosynthetic ..
  72. GLUCOCORTICOID REGULATION OF LUNG TROPOELASTIN
    Richard Pierce; Fiscal Year: 1999
    b>Elastin is a critical component of the lung extracellular matrix and provides elastic recoil to the alveolar wall...