collagen type i


Summary: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.

Top Publications

  1. pmc Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis
    L Xu
    Division of Liver Diseases, Department of Medicine, Box 1123, Mount Sinai School of Medicine, 1425 Madison Avenue, Room 11 70C, New York, NY10029, USA
    Gut 54:142-51. 2005
  2. pmc New perspectives on osteogenesis imperfecta
    Antonella Forlino
    Department of Biochemistry, Section of Medicine and Pharmacy, University of Pavia, Italy
    Nat Rev Endocrinol 7:540-57. 2011
  3. pmc Collagen density promotes mammary tumor initiation and progression
    Paolo P Provenzano
    Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA
    BMC Med 6:11. 2008
  4. ncbi MicroRNA-29, a key regulator of collagen expression in systemic sclerosis
    Britta Maurer
    University Hospital Zurich and Zurich Center of Integrative Human Physiology, Zurich, Switzerland
    Arthritis Rheum 62:1733-43. 2010
  5. pmc Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling
    Yasushi Shintani
    Department of Oral Biology, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Am J Respir Cell Mol Biol 38:95-104. 2008
  6. pmc Consortium for osteogenesis imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycans
    Joan C Marini
    Bone and Extracellular Matrix Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892, USA
    Hum Mutat 28:209-21. 2007
  7. pmc Interpreting second-harmonic generation images of collagen I fibrils
    Rebecca M Williams
    Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Biophys J 88:1377-86. 2005
  8. ncbi Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallate
    Audrey Dooley
    Centre for Rheumatology and Connective Tissue Disease, University College London Medical School, Royal Free Campus, London, UK
    Rheumatology (Oxford) 49:2024-36. 2010
  9. ncbi Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1
    Teet Velling
    Institute of Medical Biochemistry and Microbiology, 75123 Uppsala, Sweden
    J Biol Chem 277:37377-81. 2002
  10. ncbi Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix
    Kevin B Hotary
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 114:33-45. 2003

Detail Information

Publications404 found, 100 shown here

  1. pmc Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis
    L Xu
    Division of Liver Diseases, Department of Medicine, Box 1123, Mount Sinai School of Medicine, 1425 Madison Avenue, Room 11 70C, New York, NY10029, USA
    Gut 54:142-51. 2005
    ..We established and characterised two human HSC cell lines termed LX-1 and LX-2, and compared their features with those of primary human stellate cells...
  2. pmc New perspectives on osteogenesis imperfecta
    Antonella Forlino
    Department of Biochemistry, Section of Medicine and Pharmacy, University of Pavia, Italy
    Nat Rev Endocrinol 7:540-57. 2011
    ..Novel treatments using cell therapy or new drug regimens hold promise for the future...
  3. pmc Collagen density promotes mammary tumor initiation and progression
    Paolo P Provenzano
    Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA
    BMC Med 6:11. 2008
    ..Importantly, regions of high breast density are associated with increased stromal collagen. Thus, the influence of the extracellular matrix on breast carcinoma development and the underlying molecular mechanisms are not understood...
  4. ncbi MicroRNA-29, a key regulator of collagen expression in systemic sclerosis
    Britta Maurer
    University Hospital Zurich and Zurich Center of Integrative Human Physiology, Zurich, Switzerland
    Arthritis Rheum 62:1733-43. 2010
    ..To investigate the role of microRNA (miRNA) as posttranscriptional regulators of profibrotic genes in systemic sclerosis (SSc)...
  5. pmc Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling
    Yasushi Shintani
    Department of Oral Biology, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Am J Respir Cell Mol Biol 38:95-104. 2008
    ..Thus, our data are consistent with the hypothesis that collagen I induces EMT in lung cancer cells by activating autocrine TGF-beta3 signaling. Epidermal growth factor also seems to initiate EMT via a TGF-dependent mechanism...
  6. pmc Consortium for osteogenesis imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycans
    Joan C Marini
    Bone and Extracellular Matrix Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892, USA
    Hum Mutat 28:209-21. 2007
    ..Our data on genotype-phenotype relationships indicate that the two collagen chains play very different roles in matrix integrity and that phenotype depends on intracellular and extracellular events...
  7. pmc Interpreting second-harmonic generation images of collagen I fibrils
    Rebecca M Williams
    Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Biophys J 88:1377-86. 2005
    ..Fibrillogenesis can be resolved in immature tissue by directly imaging backward-propagating SHG. Such findings are crucial to the design and development of forthcoming diagnostic and research tools...
  8. ncbi Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallate
    Audrey Dooley
    Centre for Rheumatology and Connective Tissue Disease, University College London Medical School, Royal Free Campus, London, UK
    Rheumatology (Oxford) 49:2024-36. 2010
    ..This study investigates the anti-fibrotic potential of the antioxidant epigallocatechin-3-gallate (EGCG) on activated dermal fibroblasts from SSc patients...
  9. ncbi Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1
    Teet Velling
    Institute of Medical Biochemistry and Microbiology, 75123 Uppsala, Sweden
    J Biol Chem 277:37377-81. 2002
    ..Thus, collagen deposition is regulated by the cells, both indirectly through integrin alpha(5)beta(1)-dependent polymerization of fibronectin and directly through collagen-binding integrins...
  10. ncbi Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix
    Kevin B Hotary
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 114:33-45. 2003
    ..These observations identify MT1-MMP as a tumor-derived growth factor that regulates proliferation by controlling cell geometry within the confines of the 3D ECM...
  11. pmc Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis
    Y Inagaki
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Bohseidai, Isehara 259 1193, Japan
    Gut 56:284-92. 2007
  12. pmc Rac1 promotes TGF-beta-stimulated mesangial cell type I collagen expression through a PI3K/Akt-dependent mechanism
    Susan C Hubchak
    Division of Kidney Diseases, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Physiol Renal Physiol 297:F1316-23. 2009
  13. pmc Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma
    Junfang Ji
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Centre for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    J Hepatol 52:690-7. 2010
    ..Using microarray analysis, we recently identified 20 miRNAs associated with HCC metastasis. Here, we carried out further analyses on one of these microRNAs, let-7g, to determine whether it is functionally linked to HCC metastasis...
  14. ncbi Molecular phylogenetics of mastodon and Tyrannosaurus rex
    Chris L Organ
    Harvard University, Cambridge, MA 02138, USA
    Science 320:499. 2008
    ..rex. Our findings suggest that molecular data from long-extinct organisms may have the potential for resolving relationships at critical areas in the vertebrate evolutionary tree that have, so far, been phylogenetically intractable...
  15. pmc Looking older: fibroblast collapse and therapeutic implications
    Gary J Fisher
    Department of Dermatology, University of Michigan, Medical Science I Bldg, R6447, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0609, USA
    Arch Dermatol 144:666-72. 2008
    ..Treatments that stimulate production of new, nonfragmented collagen should provide substantial improvement to the appearance and health of aged skin...
  16. ncbi Factors involved in the regulation of type I collagen gene expression: implication in fibrosis
    Asish K Ghosh
    Section of Rheumatology, Department of Medicine, 1158 Molecular Biology Research Building, University of Illinois, 900 South Ashland Avenue, Chicago, IL 60607, USA
    Exp Biol Med (Maywood) 227:301-14. 2002
    ..In this review, I discuss the present day understanding about the involvement of different factors in the regulation of basal as well as cytokine-modulated Type I collagen gene expression and its implication in scleroderma research...
  17. ncbi Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment
    Robert E Marx
    Division of Oral and Maxillofacial Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    J Oral Maxillofac Surg 65:2397-410. 2007
    ..To assess the risk and time course of oral bisphosphonate-induced osteonecrosis of the jaws...
  18. ncbi Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats
    Steven Dooley
    Institut fur Klinische Chemie und Pathobiochemie, RWTH Universitätsklinikum, Aachen, Germany
    Gastroenterology 125:178-91. 2003
    ..To perturb the TGF-beta pathway during this process, we overexpressed Smad7, an intracellular antagonist of TGF-beta signaling, in vivo and in primary-cultured hepatic stellate cells (HSCs)...
  19. ncbi Identification of a novel NF-kappaB-binding site with regulation of the murine alpha2(I) collagen promoter
    Gennadiy Novitskiy
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
    J Biol Chem 279:15639-44. 2004
    ..The effects of acetaldehyde in increasing the translocation of NF-kappaB to the nucleus with increased DNA binding activity may be important in mediating the effects of acetaldehyde on other genes...
  20. ncbi Vitronectin and collagen I differentially regulate osteogenesis in mesenchymal stem cells
    Anup K Kundu
    Department of Chemical Engineering and Materials Science, University of California, Irvine, USA
    Biochem Biophys Res Commun 347:347-57. 2006
    ..Understanding these mechanistic differences is essential to predictably control the osteogenic differentiation of MSCs and widen their use in regenerative medicine...
  21. pmc CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes
    Marianne Niedermeier
    Department of Internal Medicine II, University Hospital Regensburg, 93042 Regensburg, Germany
    Proc Natl Acad Sci U S A 106:17892-7. 2009
    ..Our data may have implications for prevention of organ fibrosis in autoimmune diseases and transplantation...
  22. ncbi Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid tumors
    Janet E Brown
    Academic Unit of Clinical Oncology, Cancer Research Centre, Weston Park Hospital, Sheffield, England, United Kingdom
    J Natl Cancer Inst 97:59-69. 2005
    ..We investigated this question in patients with bone metastases secondary to prostate cancer and to non-small-cell lung cancer (NSCLC) and other solid tumors assigned to the placebo arms of two phase III trials of zoledronic acid...
  23. ncbi The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression
    Shimon Reif
    Division of Digestive Diseases, Department of Medicine, University of North Carolina, Chapel Hill 27599, USA
    J Biol Chem 278:8083-90. 2003
    ..PI3K is positioned downstream of FAK. Signals for HSC proliferation are transduced through FAK, PI3K, and Akt. Finally, expression of type I collagen is regulated by the PI3K-Akt signaling pathway...
  24. ncbi Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent Smad pathways: the role of Smad3
    Fuye Yang
    Department of Medicine and Therapeutic, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
    Hypertension 54:877-84. 2009
    ..In conclusion, Ang II induces tubular CTGF expression and renal fibrosis via the TGF-beta-dependent and -independent Smad3 signaling pathways, suggesting that targeting Smad3 may have therapeutic potential for hypertensive nephropathy...
  25. pmc Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1
    Markella Ponticos
    Centre for Rheumatology, Department of Medicine, University College of London, United Kingdom
    Mol Cell Biol 24:6151-61. 2004
    ..b>Collagen type I is one of the most abundant of the ECM proteins...
  26. pmc Bone marrow osteoblastic niche: a new model to study physiological regulation of megakaryopoiesis
    Isabella Pallotta
    Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, USA
    PLoS ONE 4:e8359. 2009
  27. ncbi Effect of different femtosecond laser-firing patterns on collagen disruption during refractive lenticule extraction
    Andri K Riau
    Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore
    J Cataract Refract Surg 38:1467-75. 2012
    ..To evaluate the changes in corneal collagen architecture subjected to different laser-firing patterns during refractive lenticule extraction...
  28. ncbi The phosphatidylinositol 3-kinase/Akt pathway enhances Smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-beta1
    Constance E Runyan
    Department of Pediatrics, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 279:2632-9. 2004
    ..This cross-talk between the Smad and PI3K pathways likely contributes to TGF-beta1 induction of glomerular scarring...
  29. ncbi Differential effects of hyaluronan and its fragments on fibroblasts: relation to wound healing
    Maha David-Raoudi
    Laboratory of Connective Tissue Biochemistry, Faculty of Medicine, Caen, France
    Wound Repair Regen 16:274-87. 2008
    ..Furthermore, the HA up-regulation of type III collagen and TGF-beta3 expression suggests that it may promote a fetal-like cell environment that favors scarless healing...
  30. pmc Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signaling
    Taihao Quan
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Pathol 165:741-51. 2004
    ..UV-induced down-regulation of TbetaRII, with attendant reduction of type I procollagen production, is a critical molecular mechanism in the pathophysiology of photoaging...
  31. ncbi Inhibition of type I procollagen production in photodamage: correlation between presence of high molecular weight collagen fragments and reduced procollagen synthesis
    James Varani
    Department of Pathology, The University of Michigan Medical School, 1301 Catherine Road Box 0602, Ann Arbor, MI 48109, U S A
    J Invest Dermatol 119:122-9. 2002
    ..As these fragments are processed further, there is less inhibition of type I procollagen production...
  32. pmc Combined integrin phosphoproteomic analyses and small interfering RNA--based functional screening identify key regulators for cancer cell adhesion and migration
    Yanling Chen
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cancer Res 69:3713-20. 2009
    ..Altogether, we not only depict an integrin-modulated phosphorylation network during cell-ECM protein interactions but also reveal novel regulators for cell adhesion and migration...
  33. ncbi Relationships between serum adiponectin, leptin concentrations and bone mineral density, and bone biochemical markers in Chinese women
    Nan Wu
    Institute of Endocrinology and Metabolism, Second Xiangya Hospital of Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, PR China corrected
    Clin Chim Acta 411:771-5. 2010
    ..However, their association with bone mineral density (BMD) is unknown. We investigated whether these serum adipocytokines concentrations are associated with BMD and bone turnover markers...
  34. pmc Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis
    Xiao Mei Wang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Exp Med 203:2895-906. 2006
    ..This study indicates a pivotal role for cav-1 in ECM regulation and suggests a novel therapeutic target for patients with pulmonary fibrosis...
  35. ncbi TGF-beta-regulated collagen type I accumulation: role of Src-based signals
    Rangnath Mishra
    Division of Nephrology, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Physiol Cell Physiol 292:C1361-9. 2007
    ..Pharmacological inhibitors and a dominant negative Src mutant prevented the increase in collagen type I secretion in cells exposed to TGF-beta...
  36. pmc Experimental murine myopia induces collagen type Iα1 (COL1A1) DNA methylation and altered COL1A1 messenger RNA expression in sclera
    Xiangtian Zhou
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Mol Vis 18:1312-24. 2012
  37. ncbi Physical properties of type I collagen extracted from fish scales of Pagrus major and Oreochromis niloticas
    Toshiyuki Ikoma
    Biomaterials Center, National Institute for Materials Science, Tsukuba, Ibaraki, Japan
    Int J Biol Macromol 32:199-204. 2003
    ..The enthalpy and entropy estimated from thermal analyses could be correlated to amino acid sequences (Gly-Pro-Hyp) of type I collagens and the number of methionine amino acid residues...
  38. ncbi Phenylbutyrate decreases type I collagen production in human lung fibroblasts
    David C Rishikof
    The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 91:740-8. 2004
    ..These data suggest that PB regulates type I collagen expression in human lung fibroblasts by mechanisms that include cAMP production and histone acetylation. PB may have therapeutic use in fibrotic lung diseases...
  39. ncbi Interstitial fibrosis is associated with increased COL1A2 transcription in AA-injured renal tubular epithelial cells in vivo
    Maria Fragiadaki
    Renal Section, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    Matrix Biol 30:396-403. 2011
    ..Overall our study provides a better understanding into the expression patterns and roles of two major extracellular matrix proteins: type I collagen and CCN2...
  40. ncbi Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment
    Siham Sabri
    Institut National de la Santé etde la Recherche Médicale INSERM, U790, Universite Paris XI, Institut Gustave Roussy, Villejut, France
    Blood 108:134-40. 2006
    ..In addition, they suggest a novel explanation for some of the platelet abnormalities characteristic of patients with WAS...
  41. ncbi Novel composite hyaluronan/type I collagen/fibrin scaffold enhances repair of osteochondral defect in rabbit knee
    Eva Filova
    Department of Tissue Engineering, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Biomed Mater Res B Appl Biomater 87:415-24. 2008
    ..The new composite scaffold containing collagen type I, hyaluronan, and fibrin, seeded with autologous chondrocytes and implanted into rabbit femoral trochlea, was ..
  42. pmc Clusterin attenuates the development of renal fibrosis
    Gwon Soo Jung
    Department of Internal Medicine, Kyungpook National University School of Medicine, 50 Samdeok 2ga, Jung Gu, Daegu 700 721, South Korea
    J Am Soc Nephrol 23:73-85. 2012
    ..In conclusion, clusterin attenuates renal fibrosis in obstructive nephropathy. These results suggest that upregulation of clusterin during renal injury is a protective response against the development of renal fibrosis...
  43. ncbi Indoxyl sulphate inhibits osteoclast differentiation and function
    Anaïs Mozar
    INSERM ERI 12, EA4292, Amiens, France
    Nephrol Dial Transplant 27:2176-81. 2012
    ..Indeed, it was recently reported that IS induces skeletal resistance to parathyroid hormone in cultured osteoblastic cells. However, it is not yet known whether IS also affects osteoclast cells...
  44. pmc Type I collagen receptor (alpha2beta1) signaling promotes prostate cancer invasion through RhoC GTPase
    Christopher L Hall
    Department of Urology, The University of Michigan, Ann Arbor, MI 48109 0940, USA
    Neoplasia 10:797-803. 2008
    ..We conclude that the ligation of alpha(2)beta(1) by collagen I activates RhoC guanosine triphosphatase, which mediates PCa invasion, and suggests a mechanism for the preferential metastasis of PCa cells within the bone...
  45. ncbi Collagen type I induces disruption of E-cadherin-mediated cell-cell contacts and promotes proliferation of pancreatic carcinoma cells
    Alexander Koenig
    Department of Internal Medicine I and Pathology, University of Ulm, Ulm, Germany
    Cancer Res 66:4662-71. 2006
    ..We show that collagen type I is able to initiate a disruption of the E-cadherin adhesion complex in pancreatic carcinoma cells...
  46. ncbi Artificial extracellular matrices composed of collagen I and sulfated hyaluronan with adsorbed transforming growth factor β1 promote collagen synthesis of human mesenchymal stromal cells
    Ute Hempel
    Institute of Physiological Chemistry, Carl Gustav Carus Faculty of Medicine, Technische Universitat Dresden, Fiedlerstrasse 42, D 01307 Dresden, Germany
    Acta Biomater 8:659-66. 2012
    ..Thus, these aECM might be a useful tool for different tissue-engineering applications to enhance bone formation when used for biomaterial coating...
  47. ncbi Growth promoting substrates for human dermal fibroblasts provided by artificial extracellular matrices composed of collagen I and sulfated glycosaminoglycans
    Anja van der Smissen
    Department of Dermatology, Venereology and Allergology, Leipzig University, Leipzig, Germany
    Biomaterials 32:8938-46. 2011
    ..Artificial ECM consisting of coll and high-sulfated GAGs proves to be a suitable biomaterial for dFb adhesion and proliferation that induces a "proliferative phenotype" of dFb found in the early stages of cutaneous wound healing...
  48. pmc Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
    Tatiana Kisseleva
    Department of Medicine, School of Pharmacy, University of California, San Diego, CA 92093, USA
    Proc Natl Acad Sci U S A 109:9448-53. 2012
    ..Inactivation of HSCs was associated with up-regulation of the anti-apoptotic genes Hspa1a/b, which participate in the survival of HSCs in culture and in vivo...
  49. ncbi A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats
    Nerea Hermida
    Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain
    Cardiovasc Res 81:601-9. 2009
    ..We investigated whether P144, a synthetic peptide from transforming growth factor-beta(1) (TGF-beta(1)) type III receptor betaglycan, exhibits cardiac antifibrotic properties...
  50. pmc Dense type I collagen matrices that support cellular remodeling and microfabrication for studies of tumor angiogenesis and vasculogenesis in vitro
    Valerie L Cross
    Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
    Biomaterials 31:8596-607. 2010
  51. pmc Loss of beta1-integrin enhances TGF-beta1-induced collagen expression in epithelial cells via increased alphavbeta3-integrin and Rac1 activity
    Tomoko Hayashida
    Division of Kidney Diseases, Department of Pediatrics, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 285:30741-51. 2010
    ..Together, our results indicate that decreasing β1 chain causes αvβ3-integrin to become functionally dominant and promotes renal cell fibrogenesis via Rac1-mediated ERK activity...
  52. ncbi Caveolin-1 increases basal and TGF-beta1-induced expression of type I procollagen through PI-3 kinase/Akt/mTOR pathway in human dermal fibroblasts
    Sangmin Kim
    Department of Dermatology, Seoul National University College of Medicine, Republic of Korea
    Cell Signal 20:1313-9. 2008
  53. ncbi Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis
    Tatiana Kisseleva
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Hepatol 45:429-38. 2006
    ..Hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis. However, their origin is still unknown. We tested the hypothesis that bone marrow (BM) contributes to the population of HSCs...
  54. pmc Interplay between β1-integrin and Rho signaling regulates differential scattering and motility of pancreatic cancer cells by snail and Slug proteins
    Mario A Shields
    Division of Hematology Oncology, Department of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 287:6218-29. 2012
  55. pmc Functionalisation of PLLA nanofiber scaffolds using a possible cooperative effect between collagen type I and BMP-2: impact on growth and osteogenic differentiation of human mesenchymal stem cells
    Markus D Schofer
    Department of Orthopedics, University Hospital of Marburg, Baldingerstraße, 35043 Marburg, Germany
    J Mater Sci Mater Med 22:1753-62. 2011
    ..Matrices composed of PLLA-collagen type I or BMP-2 incorporated PLLA-collagen type I were seeded with human mesenchymal stem cells (hMSC) and ..
  56. ncbi Regulation of extracellular matrix genes by arecoline in primary gingival fibroblasts requires epithelial factors
    G S Thangjam
    Department of Molecular Reproduction Development and Genetics, Indian Institute of Science, Bangalore, India
    J Periodontal Res 44:736-43. 2009
    ..The basic aim of our study was to elucidate the mechanism underlying the action of arecoline on the expression of genes in oral fibroblasts...
  57. pmc Contribution of bone marrow-derived cells to skin: collagen deposition and wound repair
    Carrie Fathke
    Department of Surgery, Box 356410, University of Washington Medical Center, 1959 NE Pacific Street, Seattle 98195, USA
    Stem Cells 22:812-22. 2004
    ..matrix and transcribe both collagen types I and III, whereas the skin-resident cells transcribed only collagen type I. Whereas endothelial progenitor cells were found early during the wound repair process, bone marrow-derived ..
  58. pmc Prediction of epigenetically regulated genes in breast cancer cell lines
    Leandro A Loss
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    BMC Bioinformatics 11:305. 2010
    ..Finally, the methylation-expression associations are ranked through a logistic regression, and their significance is quantified through permutation analysis...
  59. ncbi Mechanical stimulation increases collagen type I and collagen type III gene expression of stem cell-collagen sponge constructs for patellar tendon repair
    Natalia Juncosa-Melvin
    Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    Tissue Eng 13:1219-26. 2007 culture, half of the stimulated and nonstimulated constructs were prepared to determine the expression of collagen type I, collagen type III, decorin, fibronectin, and glyceraldehyde-3-phosphate dehydrogenase genes using real-time ..
  60. ncbi Mechanical properties of single electrospun collagen type I fibers
    Lanti Yang
    Polymer Chemistry and Biomaterials, Faculty of Science and Technology and Institute for Biomedical Technology BMTI, University of Twente, P O Box 217, 7500 AE, Enschede, The Netherlands
    Biomaterials 29:955-62. 2008
    ..Cross-linking of the electrospun fibers with glutaraldehyde vapor increased the shear modulus of the fiber from approximately 30 to approximately 50 MPa at ambient conditions...
  61. ncbi Suppression of type I collagen production by microRNA-29b in cultured human stellate cells
    Tomohiro Ogawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Biochem Biophys Res Commun 391:316-21. 2010
    ..It is anticipated that miR-29b will be used for the regulation of stellate cell activation and lead to antifibrotic therapy...
  62. pmc Mutations in PPIB (cyclophilin B) delay type I procollagen chain association and result in perinatal lethal to moderate osteogenesis imperfecta phenotypes
    Shawna M Pyott
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Hum Mol Genet 20:1595-609. 2011
  63. ncbi Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGF-beta2 in human retinal pigment epithelial cells
    Yuji Itoh
    Department of Ophthalmology, Oita University, Hasama machi, Yufu shi Oita 879 5593, Japan
    Exp Eye Res 84:464-72. 2007
    ..The RhoA/Rho-kinase pathway may be a therapeutic target for treating PVR...
  64. ncbi Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells
    Zixue Jin
    Institute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, China
    Hepatology 53:219-29. 2011
    ..The inflammatory cytokines IL-4 and IL-13 produced by NKT cells played a pivotal role in HSCs activation in an in vitro coculture experiment...
  65. pmc COL1A1 and COL2A1 genes and myopia susceptibility: evidence of association and suggestive linkage to the COL2A1 locus
    Ravikanth Metlapally
    Center for Human Genetics, North Carolina, USA
    Invest Ophthalmol Vis Sci 50:4080-6. 2009
    ..This study was conducted to investigate whether these collagen genes are associated and/or genetically linked with myopia in large Caucasian family datasets...
  66. pmc Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation
    Feng Hong
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 49:2055-67. 2009
    ..Inhibitor studies suggest that SDF-1alpha/CXCR4-dependent extracellular signal-regulated kinase 1/2 and Akt phosphorylation mediate effects on collagen I expression and stellate cell proliferation...
  67. ncbi Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis
    Guntram A Grassl
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    Gastroenterology 134:768-80. 2008
    ..Here, we present a novel murine model of severe and persistent intestinal fibrosis caused by chronic bacterial-induced colitis...
  68. ncbi Oxidative stress mediates cardiac fibrosis by enhancing transforming growth factor-beta1 in hypertensive rats
    Wenyuan Zhao
    Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, 956 Court Avenue Rm B310, Memphis, TN, 38163, USA
    Mol Cell Biochem 317:43-50. 2008
    ..Thus, cardiac oxidative stress promotes the development of cardiac fibrosis by upregulating TGF-beta1 expression, which subsequently enhances cardiac collagen synthesis and suppresses collagen degradation in hypertensive rats...
  69. ncbi Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell-like property
    R Salingcarnboriboon
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Exp Cell Res 287:289-300. 2003
    ..These observations indicated that the established tendon cell line possesses mesenchymal stem cell-like properties, suggesting the existence of mesenchymal stem cell in tendon tissue...
  70. ncbi Enhanced biological stability of collagen porous scaffolds by using amino acids as novel cross-linking bridges
    Lie Ma
    Department of Polymer Science and Engineering, Zhejiang University, No 38, Zheda Road, Hangzhou, Zhejiang 310027, China
    Biomaterials 25:2997-3004. 2004
    ..Preliminary in vitro culture of fibroblasts in the collagen scaffold cross-linked with EDAC/NHS in the presence of lysine has shown that the original good cytocompatibility of collagen was retained...
  71. ncbi Smad3 mediates the TGF-beta-induced contraction of type I collagen gels by mouse embryo fibroblasts
    Xiangde Liu
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5125, USA
    Cell Motil Cytoskeleton 54:248-53. 2003
    ..Thus, the Smad3 gene could be a target for blocking contraction of fibrotic tissue induced by TGF-beta...
  72. ncbi Membrane type 1 matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-related kinase activation and cell migration
    Takahisa Takino
    Department of Molecular Virology and Oncology and Cell Cycle Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Res 64:1044-9. 2004
    ..Thus, adhesion of HT1080 cells to type I collagen induces MT1-MMP-dependent ERK activation, which in turn causes an increase in MT1-MMP levels and subsequent cell migration...
  73. pmc PKCalpha mediates CCL18-stimulated collagen production in pulmonary fibroblasts
    Irina G Luzina
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Respir Cell Mol Biol 35:298-305. 2006
    ..These observations suggest that in primary pulmonary fibroblasts, PKCalpha but not PKCdelta or PKCepsilon mediate the profibrotic effect of CCL18. PKCalpha may therefore become a viable target for future antifibrotic therapies...
  74. pmc Early response of alpha2(I) collagen to acetaldehyde in human hepatic stellate cells is TGF-beta independent
    Gianluca Svegliati-Baroni
    Clinica di Gastroenterologia, Universita Politecnica delle Marche, Ancona, Italy
    Hepatology 42:343-52. 2005
    ..We suggest that early acetaldehyde-dependent events induce the late expression of TGF-beta1 and create an H(2)O(2)-dependent autocrine loop that may sustain and amplify the fibrogenic response of this alcohol metabolite...
  75. pmc Type I collagen synthesis and degradation in peritendinous tissue after exercise determined by microdialysis in humans
    H Langberg
    Sports Medicine Research Unit, Department of Rheumatology H and Department of Clinical Physiology, Bispebjerg Hospital, Copenhagen, Denmark
    J Physiol 521:299-306. 1999
    ..This suggests an adaptation to acute physical loading also in non-bone-related collagen in humans...
  76. pmc Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma
    Sukhvinder S Sidhu
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 107:14170-5. 2010
    ..Epithelial cell-derived periostin in asthma has roles in TGF-beta activation and collagen gel elasticity in asthma...
  77. ncbi Identification of novel target genes by an epigenetic reactivation screen of renal cancer
    Inmaculada Ibanez de Caceres
    Departments of Surgical Oncology and Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 66:5021-8. 2006
  78. ncbi Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2
    Elvira Olaso
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 277:3606-13. 2002
    ..These data establish a role for DDR2 in critical events during wound repair...
  79. ncbi Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis
    Hiroyuki Higashiyama
    Pharmacology Department, Tsukuba Research Laboratories, GlaxoSmithKline KK, 43 Wadai, Tsukuba, Ibaraki, 300 4247, Japan
    Exp Mol Pathol 83:39-46. 2007
    ..These results suggest that ALK5 inhibition attenuates R-Smads activation thereby attenuates pulmonary fibrosis...
  80. pmc Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2
    Surabhi Dangi-Garimella
    Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cancer Res 71:1019-28. 2011
  81. ncbi Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland
    Wendy V Ingman
    Department of Molecular and Developmental Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Dev Dyn 235:3222-9. 2006
    ..Macrophage deficiency also caused terminal end buds to be rounder and shorter. These studies reveal a role for macrophages in collagen fibrillogenesis and in organization of the structure of terminal end buds...
  82. ncbi The mechanical memory of lung myofibroblasts
    Jenna L Balestrini
    Laboratory of Tissue Repair and Regeneration, Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Fitzgerald Building, Room 234, 150 College Street, Toronto, ON M5S3E2, Canada
    Integr Biol (Camb) 4:410-21. 2012
    ..This priming effect has important implications for the progression and persistence of aggressive fibrotic diseases such as idiopathic pulmonary fibrosis...
  83. ncbi Modeling and quantification of cancer cell invasion through collagen type I matrices
    Olivier De Wever
    Laboratory of Experimental Cancer Research, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, Gent, Belgium
    Int J Dev Biol 54:887-96. 2010
    ..Initiation and monitoring of the single-cell and spheroid invasion model can be achieved in 8 h (over 3 days) and in 14 h (over 8 days) respectively...
  84. ncbi Hereditary dentin defects
    J W Kim
    Seoul National University, School of Dentistry Department of Pediatric Dentistry and Dental Research Institute, 28 2 Yongon Dong, Chongno Gu, Seoul, Korea 110 749
    J Dent Res 86:392-9. 2007
  85. ncbi Alteration of activity and survival of osteoblasts obtained from human periodontitis patients: role of TRAIL
    G Mori
    Department of Human Anatomy and Histology, University of Bari, Italy
    J Biol Regul Homeost Agents 21:105-14. 2007
    ..In particular, the alkaline phosphatase activity and the collagen type I production, as well as the formation of mineralized nodules, typical markers of differentiated OBs, were ..
  86. ncbi Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 175:7708-18. 2005
    ..These results suggest that the up-regulated expression of alpha(v)beta3 contributes to the establishment of autocrine TGF-beta loop in scleroderma fibroblasts, and this integrin is a potent target for the treatment of scleroderma...
  87. ncbi Effect of IGF-I and PDGF administered in vivo on the expression of osteoblast-related genes in old rats
    H Tanaka
    Department of Orthopedic Surgery, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Japan
    J Endocrinol 174:63-70. 2002
  88. pmc Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation
    Jing Lin Xia
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Pathol 168:1500-12. 2006
    ..HGF abolished the phenotypic conversion of biliary epithelial cells induced by TGF-beta1. These results suggest that HGF ameliorates hepatic biliary fibrosis in part by blocking bile duct epithelial to mesenchymal transition...
  89. pmc Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis
    Hong Xia
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 205:1659-72. 2008
    ..These results provide direct evidence for defective negative regulation of the proliferative pathway in IPF fibroblasts and support the theory that the pathogenesis of IPF involves an intrinsic fibroblast defect...
  90. ncbi Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells
    Hideaki Sowa
    Third Department of Medicine, Kobe University School of Medicine, Japan
    J Bone Miner Res 17:1190-9. 2002
    ..We propose that Smad3 plays an important role in osteoblastic bone formation and might help to elucidate the transcriptional mechanism of bone formation and possibly lead to the development of bone-forming drugs...
  91. pmc Null mutations in LEPRE1 and CRTAP cause severe recessive osteogenesis imperfecta
    Joan C Marini
    Bone and Extracellular Matrix Branch, NICHD, NIH, Bethesda, MD 20892, USA
    Cell Tissue Res 339:59-70. 2010
  92. ncbi The linker region of Smad2 mediates TGF-beta-dependent ERK2-induced collagen synthesis
    Fengfeng Li
    Department of Orthopaedics, The Sixth Affiliated People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200233, China
    Biochem Biophys Res Commun 386:289-93. 2009
    ..These results indicate that ERK2, rather than ERK1, plays a predominantly positive role in TGF-beta1-induced collagen synthesis, and that ERK2 enhances collagen synthesis, at least partially, through activation of the Smad2 linker site...
  93. ncbi The effects of enamel matrix derivative (EMD) on osteoblastic cells in culture and bone regeneration in a rat skull defect
    Satoshi Yoneda
    Masticatory Function Control, Tokyo Medical and Dental University, Yushima, Tokyo, Japan
    J Periodontal Res 38:333-42. 2003
    ..Enamel matrix derivative (EMD) has been clinically used to promote periodontal tissue regeneration. The purpose of the present study is to clarify EMD affects on osteoblastic cells and bone regeneration...
  94. ncbi Imbalance in the synthesis of collagen type I and collagen type III in smooth muscle cells derived from human varicose veins
    P Sansilvestri-Morel
    Division of Angiology, Servier Research Institute, Suresnes, France
    J Vasc Res 38:560-8. 2001
    ..An imbalance between the synthesis of collagen type I protein (collagen I) and collagen type III protein (collagen III) could explain the lack of elasticity of ..
  95. ncbi Prostaglandin E(2) inhibits collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2 receptor and cAMP signaling
    Steven Huang
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Am J Physiol Lung Cell Mol Physiol 292:L405-13. 2007
    ..Our data indicate that PGE(2) inhibits fibroblast activation in primary lung fibroblasts via binding of EP2 receptor and production of cAMP; inhibition of collagen I proceeds via activation of PKA...
  96. pmc Defective collagen crosslinking in bone, but not in ligament or cartilage, in Bruck syndrome: indications for a bone-specific telopeptide lysyl hydroxylase on chromosome 17
    R A Bank
    Gaubius Laboratory TNO Prevention and Health, Division of Vascular and Connective Tissue Research, P O Box 2215, 2301 CE Leiden, The Netherlands
    Proc Natl Acad Sci U S A 96:1054-8. 1999
    ..We report that lysine residues within the telopeptides of collagen type I in bone are underhydroxylated, leading to aberrant crosslinking, but that the lysine residues in the triple ..
  97. ncbi Zoledronic acid and survival in breast cancer patients with bone metastases and elevated markers of osteoclast activity
    Allan Lipton
    Milton S Hershey Medical Center, Penn State Cancer Institute, 500 University Drive, Hershey, Pennsylvania 17033, USA
    Oncologist 12:1035-43. 2007
  98. pmc Homozygosity for a missense mutation in SERPINH1, which encodes the collagen chaperone protein HSP47, results in severe recessive osteogenesis imperfecta
    Helena E Christiansen
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 86:389-98. 2010
    ..Identification of this mutation in SERPINH1 gives further insight into critical steps of the collagen biosynthetic pathway and the molecular pathogenesis of OI...
  99. ncbi Differential regulation of actin stress fiber assembly and proplatelet formation by alpha2beta1 integrin and GPVI in human megakaryocytes
    Siham Sabri
    Institut National de la Sante et de la Recherche Medicale, U362, Institut Gustave Roussy, rue Camille Desmoulins, 94800 Villejuif, France
    Blood 104:3117-25. 2004
    ..In the marrow microenvironment, mature MKs are in contact with the extracellular matrix, including fibrillar collagen type I. MKs express alpha2beta1 integrin and the immunoglobulin superfamily member glycoprotein VI (GPVI), the main ..
  100. ncbi Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9
    Azuma Watanabe
    Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA
    Hepatology 46:1509-18. 2007
    ..Stimulation of TLR9 on HSCs blocked signaling by the PDGF signaling molecule inositol 1,4,5-triphosphate and reduced PDGF-mediated increase in cytosolic Ca(2+)...
  101. ncbi Enhanced bronchial expression of extracellular matrix proteins in chronic obstructive pulmonary disease
    Andor R Kranenburg
    Department of Pharmacology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Am J Clin Pathol 126:725-35. 2006
    ..Our data suggest that COPD exhibits increased bronchial deposition of ECM proteins that contribute to deteriorated lung function and airway remodeling...

Research Grants74

  1. Hematopoietic Stem Cell Transplantation in Osteogenesis Imperfecta
    Meenal Mehrotra; Fiscal Year: 2012
    ..Long term, these findings have the potential to identify HSC transplantation, and not the transplantation of MSCs or progenitor cells, as the therapy of choice for this collagen disorder. ..
  2. Conditional Knockout of Calcium Receptors in Bone Cells
    Dolores M Shoback; Fiscal Year: 2013
  3. Pluripotent human stem cells as models for normal and diseased trophoblast
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2013
    ..Also by generating such pluripotent cells from umbilical cords of babies born to mothers that developed pre-eclampsia, we hope to recreate the cell type that caused the disease in the first place. ..
    Miriam Falzon; Fiscal Year: 2009
    ..matrix proteins collagen types I and IV, laminin, and fibronectin;(c) migration onto laminin and collagen type I;(d) invasion of Matrigel, a reconstituted basement membrane;(e) anchorage-independent cell growth;(f) cell ..
    EunDuck P Kay; Fiscal Year: 2010
    ..Such detailed information is crucial for targeting the specific stage and specific pathway before inflammation causes an irreversible EMT. ..
  6. 3D human skin models
    Meenhard Herlyn; Fiscal Year: 2010
    ..and, optionally, also endothelial, smooth muscle, and inflammatory, and immune cells that are all embedded in collagen type I;2) 'epidermis'consisting of multilayered keratinocytes at distinct differentiation stages and ..
  7. Suppression of Collagen Induced Arthritis with Altered Peptide Ligands
    Andrew H Kang; Fiscal Year: 2010
    ..Other peptidesef that a definitive understanding of the mechanism(s) through which A9 suppresses arthritis will facilitate the development of improved treatments for RA. ..
  8. Effect of botulinum toxin plus vibration on bone in children with cerebral palsy
    Christopher M Modlesky; Fiscal Year: 2012
  9. Leads and Target Validation for Vascular Calcification in Chronic Kidney Disease
    Jose Luis Millan; Fiscal Year: 2010
    ..Our studies will validate a therapeutic target for medial calcification and will optimize new lead chemicals to prevent/treat arterial calcification in established animal models, thus filling this unmet clinical need. ..
  10. Cathespin K Radioligands for In Vivo Imaging
    Michael R Kilbourn; Fiscal Year: 2012
  11. Assessing the Impact of Osteogenesis Imperfecta on Non-Skeletal Systems
    Laura Tosi; Fiscal Year: 2012
  12. The role of TNF-Alpha in cutaneous integrity
    Victoria P Werth; Fiscal Year: 2013
    ..This information will facilitate evaluation and development of potential interventions to prevent these extensive and destructive changes in skin. ..
  13. Invasive Behavior of Tumor Cells Producing Collagenase-1
    Constance E Brinckerhoff; Fiscal Year: 2013
    ..Inhibiting MMP-1 gene expression may, therefore, be useful in therapeutically controlling melanoma metastasis. ..
  14. Optimizing Normal Collagen Replacement in Osteogenesis Imperfecta
    Sarah L Dallas; Fiscal Year: 2013
    ..These studies have the potential to lead to novel or improved treatments for patients with OI. ..
  15. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2010
    ..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
  16. Modeling Dentin by G Protein Coupled Receptor Signaling
    Orapin V Horst; Fiscal Year: 2013
    ..Horst's natural progression from current research experiences to the mentored clinical scientist development phase and then to independence. ..
    Esteban Mezey; Fiscal Year: 2011
    ..Furthermore, the role of oxidant stress and nitric oxide as mediators of the activating effect of TGFalpha and acetaldehyde on the human alpha1 (I) collagen promoter will be investigated. ..
  18. Transforming Growth Factor-Beta (TGF-b) Signaling in Aged Skin
    Taihao Quan; Fiscal Year: 2013
    ..This hypothesis is novel because it focuses on the importance of the extracellular matrix, rather than inherent cellular deficits, as a driving force for the aging process in humans. ..
  19. Identification of a novel population in the adult bone marrow
    Ernestina Schipani; Fiscal Year: 2012
    ..The accomplishment of the experiments described in Aims I and II will likely expand our knowledge on the pathogenesis of bone marrow fibrosis, at least in a context of chronic activation of the PTH receptor. ..
  20. Translation Regulation of Collagen-1 in Liver Fibrosis: Target of Drug Discovery
    Zarko Manojlovic; Fiscal Year: 2013
  21. Combinatorial Metal Oxide Substrates to Enhance Osteogenic Stem Cell Functions
    Jaime E Ramírez-Vick; Fiscal Year: 2012
    ..Aim 2: Determine the type, distribution and conformation of select serum and/or ECM adhesive proteins such as collagen type I, fibronectin, laminin, and vitronectin, adsorbed onto the novel material substrates prepared by the research ..
  22. Role of Surface Roughness in Regulating Tumor Cell Behavior
    Sarah C Glover; Fiscal Year: 2012
  23. Targeted Correction of Dominant Mutations of Type I Collagen Causing Severe OI
    David W Rowe; Fiscal Year: 2013
    Steven L Teitelbaum; Fiscal Year: 2013
    ..Additionally Syt VII regulates OB exocytosis. Hence, our specific aims are to determine the mechanisms by which 1) PKC;signaling promotes OC polarization and 2) synaptotagmin VII controls exocytosis by OCs and OBs. ..
  25. Apoptosis and Fibrosis
    ARIEL R JOHNSON; Fiscal Year: 2013
    ..One characteristic of fibrosis is an increase in the synthesis of collagen type I (COL1) and decreases in both synthesis of COL3 and degradation of COL1...
  26. Osteoblast and Odontoblast Specific Regulatory Action of Runx2 for Bone and Tooth
    MITRA D ADHAMI; Fiscal Year: 2013
    ..Eventually, the proposed studies will facilitate the development of novel diagnostic tools and therapeutic treatments regarding dentin matrix malformations, skeletal abnormalities, and craniofacial dysplasias. ..
    Sarah L Dallas; Fiscal Year: 2013
    ..As these studies will significantly advance our mechanistic understanding the process of bone formation, the research has implications for treatment of osteoporosis, osteogenesis imperfecta and metabolic bone diseases. ..
  28. Targeting myofibroblast activation in chronic fibrotic disease
    ARTHUR ROGER STRAUCH; Fiscal Year: 2011
    ..abstract_text> ..
  29. PET Imaging of Pulmonary Fibrosis
    PETER D CARAVAN; Fiscal Year: 2013
    ..End of Abstract) ..
  30. Regulated expression of B. burgdorferi virulence genes
    FELIPE CARDENAS CABELLO; Fiscal Year: 2010
    ..burgdorferi. These tools will be used to identify genes that are potentially responsible for this organism's virulence and which could be targets for new vaccines and antibiotics against Lyme disease. ..
  31. Regulation of Type I Collagen in Hepatic Fibrosis
    Branko Stefanovic; Fiscal Year: 2012
    ..The results will elucidate this unique mechanism of collagen synthesis in HSCs and identify the regulatory roles of the factors involved, as potential targets for development of antifibrotic drugs. ..
  32. Peri-arteriolar Myofibroblast Differentiation in the Pathobiology of IPAH
    ARTHUR ROGER STRAUCH; Fiscal Year: 2012
    ..abstract_text> ..
  33. Optimization of Efficacy and Safety Pharamacology of Fibrosis Imaging Agent CM-65
    ..The ability of this development candidate to noninvasively stage fibrosis by MRI will be fully evaluated in two orthogonal animal models of disease. ..
    David W Russell; Fiscal Year: 2010
    ..The research will also have broader implications, since gene targeting methods for human MSCs could potentially be applied to many diseases of bone, cartilage, muscle, and possibly other tissues. ..
  35. Regulation of Extracellular Matrix Homeostatsis in Skin Aging
    Gary J Fisher; Fiscal Year: 2013
    ..abstract_text> ..
  36. Role of IGF-1 and Estrogen in Skeletal Anabolic Response to Loading
    Chandrasekhar Kesavan; Fiscal Year: 2011
    ..Our understanding of the role of IGF-I and estrogen in mediating bone formation response to loading will lead to development of strategies to increase bone anabolic response to ML by modulating local IGF-I actions in bone. ..
  37. MMP14-dependent regulation of adipose tissue remodeling and function (R01)
    Tae Hwa Chun; Fiscal Year: 2013
    ..The knowledge will help us understand the pathogenesis of insulin resistance and obesity-related metabolic diseases from the perspective of peri-adipocyte collagen turnover. ..
  38. Flow Perfusion Bioreactor Fabrication of Bioactive Polymer/ECM Hybrid Constructs
    Antonios G Mikos; Fiscal Year: 2013
    ..g., collagen type I for bone and collagen type II for cartilage)...
  39. Peptide therapeutics for inhibiting abdominal adhesions
    CYNTHIA ELLEN LANDER; Fiscal Year: 2012
    ..MK2 is implicated in the connective tissue growth factor (CTGF) and collagen type I up regulation that promotes adhesions...
  40. Fibrosis-Protease Cross-Talk Regulating Pancreatic Cancer Invasion
    Hidayatullah G Munshi; Fiscal Year: 2013
    ..abstract_text> ..
  41. Role of Fox03a in Regulating the IPF Fibroblast Phenotype
    RICHARD S NHO; Fiscal Year: 2010
    ..Identifying key regulatory nodes controlling the pathologic behavior of IPF fibroblasts may provide molecular therapeutic targets to limit the progressive fibrosis that characterizes IPF. ..
  42. Molecular Mechanisms by which TNFalpha Modulates Fibrosis
    David A Brenner; Fiscal Year: 2013
    ..This proposal uses the wound healing model of hepatic fibrosis to assess how TNF? modulates wound healing through different signal transduction pathways in the whole organism and in specific hepatic cell populations. ..
  43. A Role of Novel Serpin Maspinin Prostate Tumor/Bone Interaction
    Shijie Sheng; Fiscal Year: 2012
    ..The expected results are likely to shed new lights on how to improve the therapeutic intervention of PC bone metastasis. ..
    SARAH DALLAS; Fiscal Year: 2009
    ..abstract_text> ..
  45. Does increasing bone mass also increase bone strength in mouse models of OI?
    Matthew L Warman; Fiscal Year: 2012
    ..Ultimately this knowledge will determine whether modulators of the LRP5/6 signaling pathway, or other therapies that are anabolic in wild-type bone, can be used to improve bone properties in human patients who have OI. ..
  46. Function of epithelial-mesenchymal transition during pulmonary fibrosis
    KEVIN KEEWOUN KIM; Fiscal Year: 2013
    ..These studies will help define previously unexplored mechanisms that may regulate fibrosis with the potential of designing new and better therapies. ..
  47. Role of Acetaldehyde on PDGF-BB-induced HSC Migration and Proliferation.
    Raj M Lakshman; Fiscal Year: 2011
    ..Our long term goal is to unravel key molecular events triggered by acetaldehyde that could lead to therapeutic intervention and thus, to prevention and/or amelioration of alcohol-induced liver fibrosis and cirrhosis. ..
  48. Bcl-2, A Key Factor for Dentinogenesis and Tooth Damage Repair
    Wenjian Zhang; Fiscal Year: 2010
    ..It is expected to generate new interventions to preserving the vitality and functions of teeth injured by infections or trauma, and contributing to fabricated teeth via bioengineering. ..
  49. Alcohol-induced liver fibrosis:an in vitro model
    Raj M Lakshman; Fiscal Year: 2012
    ..These studies have the potential to yield novel therapeutic modalities to treat or ameliorate this disease. ..
  50. Origins of Elasticity and Viscoelasticity in Ligaments
    Jeffrey A Weiss; Fiscal Year: 2013
    Frederick Grinnell; Fiscal Year: 2012
    ..Indeed, the general usefulness of 3D matrix models to accelerate a wide range of translational research work increasingly has been recognized. ..
  52. The Importance of Prolyl 3-hydroxylation in recessive Osteogenesis Imperfecta
    ERICA PAIGE HOMAN; Fiscal Year: 2013
    ..abstract_text> ..
  53. The mechanism of a Chinese herbal formula on cancer pain
    Ling Xu; Fiscal Year: 2012
    ..This study will evaluate the effects and mechanisms of an herb formula Tongluo Sanjie (TLSJ) on such pain in rat models. The success of the proposed study will greatly advance the management of cancer pain. ..
  54. Uveitogenic Epitope(s) and Idiopathic Anterior Uveitis
    Nalini S Bora; Fiscal Year: 2013
    ..Additionally, these studies will facilitate the development of antigen based therapeutic interventions for human IAU which is associated with significant morbidity. ..
  55. Treating Alcoholic Liver Fibrosis by Reversal of Type I Collagen
    Kun Cheng; Fiscal Year: 2010
    ..Successful accomplishment of this project will provide an effective therapeutics to treat alcoholic liver fibrosis by inducing degradation of the accumulated type I collagen. ..
  56. Bone Sialprotein in Osteogenesis and Bone Regeneration
    Jinxi Wang; Fiscal Year: 2013
    ..Specific Aim 3 will identify BSP-specific osteogenic activities for the repair of cranial defects. ..
    Hidekazu Tsukamoto; Fiscal Year: 2013
    ..New information generated by these studies with support from the core, will lead to identification of new treatment modalities for the diseases. ..
  58. Sclerostin Antibody Therapy for Treatment of Osteogenesis Imperfecta
    Kenneth M Kozloff; Fiscal Year: 2013
  59. Growth Factors;Effect on Aspects of Bone Formation
    Ernesto Canalis; Fiscal Year: 2012
    ..These investigations should clarify the role of Nov in bone cell function, and its interactions with BMP and Wnt signaling pathways. ..
  60. Extracellular matrix remodeling and fibrosis
    JANE M SOTTILE; Fiscal Year: 2013
    ..polymerizing) FN into the ECM regulates the deposition and stability of other ECM molecules, including collagen type I. In addition, agents that we and others have used to inhibit FN polymerization, such as the peptide pUR4, ..
  61. Targeting the Lrp5 Pathway To Increase Bone Strength In Osteogenesis Imperfecta
    ..Finally, using a mouse OI model, I will identify therapeutic strategies that best improve bone properties while minimizing the side effects of therapy. ..
  62. New In Vitro Human Liver Toxicity Bioassay System
    Raj K Singh; Fiscal Year: 2013
    ..VBI will develop a market-ready 3D-liver assay platform adaptable to HTS applications. Sale of 3D HuBiogel culture kits or in-house bioassay services would have significant world-wide market, as a research &diagnostic tool. ..
    Christopher Niyibizi; Fiscal Year: 2000
    ..abstract_text> ..
    MARK ZORN; Fiscal Year: 1991
    ..Collagen type III is less able to resist stretch than is collagen type I. The amount of collagen type III relative to collagen type I decreases as the eye matures...
    Deborah Redford Badwal; Fiscal Year: 1993
    ..The strategy should be applicable to defining mutations of any gene that is expressed in cartilage and provide an avenue for understanding the molecular basis of this extremely heterogeneous group of heritable disorders...
  66. Investigating Ultrastructural Collagen Changes in Osteogenesis Imperfecta
    Joseph Wallace; Fiscal Year: 2009
    ..Therefore, this research is not only applicable to Ol patients, but has broader implications for investigating other diseases related to ultrastructural modifications of bone. ..
  67. Multiscale structural and mechanical analysis of soft tissue under complex loads
    SPENCER PARK LAKE; Fiscal Year: 2012
    ..two scales directly, was recently applied successfully to evaluate biaxial tensile testing of cell-seeded collagen Type I gels (tissue- equivalents, or TEs)...
  68. CYR61-a novel potential mediator of photoaged human skin
    Taihao Quan; Fiscal Year: 2010
    ..Results from the proposed studies will provide a foundation of knowledge regarding the role of CYR61 in human skin. ..
  69. Inhibition of Collagen Synthesis by RNA Interference
    Kyonggeun Yoon; Fiscal Year: 2003
    Christopher Niyibizi; Fiscal Year: 2001
    Igor Prudovsky; Fiscal Year: 2005
    ..abstract_text> ..
  72. Idiopathic Anterior Uveitis and Type I Collagen
    NALINI BORA; Fiscal Year: 2009
    ..These observations should also allow the development of effective therapy based on selective antigen specific modulation of the immune response in the treatment of this disease. ..
  73. Using gold nanorods to modify the extracellular matrix and mechanical properties
    Edie C Goldsmith; Fiscal Year: 2010
    ..Of the ECM proteins present, collagen type I is particularly important because it is responsible for the structural support and mechanical durability of ..
    Bhavna Shroff; Fiscal Year: 1991
    ..These two specific aims will be tested during a one year period to collect preliminary datas essential to the further understanding of the mechanism of tooth eruption and its regulation...