Genomes and Genes
collagen type i
Summary: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
Publications404 found, 100 shown here
- Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosisL Xu
Division of Liver Diseases, Department of Medicine, Box 1123, Mount Sinai School of Medicine, 1425 Madison Avenue, Room 11 70C, New York, NY10029, USA
Gut 54:142-51. 2005..We established and characterised two human HSC cell lines termed LX-1 and LX-2, and compared their features with those of primary human stellate cells...
- New perspectives on osteogenesis imperfectaAntonella Forlino
Department of Biochemistry, Section of Medicine and Pharmacy, University of Pavia, Italy
Nat Rev Endocrinol 7:540-57. 2011..Novel treatments using cell therapy or new drug regimens hold promise for the future...
- Collagen density promotes mammary tumor initiation and progressionPaolo P Provenzano
Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA
BMC Med 6:11. 2008..Importantly, regions of high breast density are associated with increased stromal collagen. Thus, the influence of the extracellular matrix on breast carcinoma development and the underlying molecular mechanisms are not understood...
- MicroRNA-29, a key regulator of collagen expression in systemic sclerosisBritta Maurer
University Hospital Zurich and Zurich Center of Integrative Human Physiology, Zurich, Switzerland
Arthritis Rheum 62:1733-43. 2010..To investigate the role of microRNA (miRNA) as posttranscriptional regulators of profibrotic genes in systemic sclerosis (SSc)...
- Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signalingYasushi Shintani
Department of Oral Biology, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA
Am J Respir Cell Mol Biol 38:95-104. 2008..Thus, our data are consistent with the hypothesis that collagen I induces EMT in lung cancer cells by activating autocrine TGF-beta3 signaling. Epidermal growth factor also seems to initiate EMT via a TGF-dependent mechanism...
- Consortium for osteogenesis imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycansJoan C Marini
Bone and Extracellular Matrix Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892, USA
Hum Mutat 28:209-21. 2007..Our data on genotype-phenotype relationships indicate that the two collagen chains play very different roles in matrix integrity and that phenotype depends on intracellular and extracellular events...
- Interpreting second-harmonic generation images of collagen I fibrilsRebecca M Williams
Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
Biophys J 88:1377-86. 2005..Fibrillogenesis can be resolved in immature tissue by directly imaging backward-propagating SHG. Such findings are crucial to the design and development of forthcoming diagnostic and research tools...
- Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallateAudrey Dooley
Centre for Rheumatology and Connective Tissue Disease, University College London Medical School, Royal Free Campus, London, UK
Rheumatology (Oxford) 49:2024-36. 2010..This study investigates the anti-fibrotic potential of the antioxidant epigallocatechin-3-gallate (EGCG) on activated dermal fibroblasts from SSc patients...
- Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1Teet Velling
Institute of Medical Biochemistry and Microbiology, 75123 Uppsala, Sweden
J Biol Chem 277:37377-81. 2002..Thus, collagen deposition is regulated by the cells, both indirectly through integrin alpha(5)beta(1)-dependent polymerization of fibronectin and directly through collagen-binding integrins...
- Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrixKevin B Hotary
Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
Cell 114:33-45. 2003..These observations identify MT1-MMP as a tumor-derived growth factor that regulates proliferation by controlling cell geometry within the confines of the 3D ECM...
- Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesisY Inagaki
Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Bohseidai, Isehara 259 1193, Japan
Gut 56:284-92. 2007
- Rac1 promotes TGF-beta-stimulated mesangial cell type I collagen expression through a PI3K/Akt-dependent mechanismSusan C Hubchak
Division of Kidney Diseases, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Am J Physiol Renal Physiol 297:F1316-23. 2009....
- Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinomaJunfang Ji
Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Centre for Cancer Research, National Cancer Institute, Bethesda, MD, USA
J Hepatol 52:690-7. 2010..Using microarray analysis, we recently identified 20 miRNAs associated with HCC metastasis. Here, we carried out further analyses on one of these microRNAs, let-7g, to determine whether it is functionally linked to HCC metastasis...
- Molecular phylogenetics of mastodon and Tyrannosaurus rexChris L Organ
Harvard University, Cambridge, MA 02138, USA
Science 320:499. 2008..rex. Our findings suggest that molecular data from long-extinct organisms may have the potential for resolving relationships at critical areas in the vertebrate evolutionary tree that have, so far, been phylogenetically intractable...
- Looking older: fibroblast collapse and therapeutic implicationsGary J Fisher
Department of Dermatology, University of Michigan, Medical Science I Bldg, R6447, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0609, USA
Arch Dermatol 144:666-72. 2008..Treatments that stimulate production of new, nonfragmented collagen should provide substantial improvement to the appearance and health of aged skin...
- Factors involved in the regulation of type I collagen gene expression: implication in fibrosisAsish K Ghosh
Section of Rheumatology, Department of Medicine, 1158 Molecular Biology Research Building, University of Illinois, 900 South Ashland Avenue, Chicago, IL 60607, USA
Exp Biol Med (Maywood) 227:301-14. 2002..In this review, I discuss the present day understanding about the involvement of different factors in the regulation of basal as well as cytokine-modulated Type I collagen gene expression and its implication in scleroderma research...
- Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatmentRobert E Marx
Division of Oral and Maxillofacial Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
J Oral Maxillofac Surg 65:2397-410. 2007..To assess the risk and time course of oral bisphosphonate-induced osteonecrosis of the jaws...
- Smad7 prevents activation of hepatic stellate cells and liver fibrosis in ratsSteven Dooley
Institut fur Klinische Chemie und Pathobiochemie, RWTH Universitätsklinikum, Aachen, Germany
Gastroenterology 125:178-91. 2003..To perturb the TGF-beta pathway during this process, we overexpressed Smad7, an intracellular antagonist of TGF-beta signaling, in vivo and in primary-cultured hepatic stellate cells (HSCs)...
- Identification of a novel NF-kappaB-binding site with regulation of the murine alpha2(I) collagen promoterGennadiy Novitskiy
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
J Biol Chem 279:15639-44. 2004..The effects of acetaldehyde in increasing the translocation of NF-kappaB to the nucleus with increased DNA binding activity may be important in mediating the effects of acetaldehyde on other genes...
- Vitronectin and collagen I differentially regulate osteogenesis in mesenchymal stem cellsAnup K Kundu
Department of Chemical Engineering and Materials Science, University of California, Irvine, USA
Biochem Biophys Res Commun 347:347-57. 2006..Understanding these mechanistic differences is essential to predictably control the osteogenic differentiation of MSCs and widen their use in regenerative medicine...
- CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytesMarianne Niedermeier
Department of Internal Medicine II, University Hospital Regensburg, 93042 Regensburg, Germany
Proc Natl Acad Sci U S A 106:17892-7. 2009..Our data may have implications for prevention of organ fibrosis in autoimmune diseases and transplantation...
- Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid tumorsJanet E Brown
Academic Unit of Clinical Oncology, Cancer Research Centre, Weston Park Hospital, Sheffield, England, United Kingdom
J Natl Cancer Inst 97:59-69. 2005..We investigated this question in patients with bone metastases secondary to prostate cancer and to non-small-cell lung cancer (NSCLC) and other solid tumors assigned to the placebo arms of two phase III trials of zoledronic acid...
- The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expressionShimon Reif
Division of Digestive Diseases, Department of Medicine, University of North Carolina, Chapel Hill 27599, USA
J Biol Chem 278:8083-90. 2003..PI3K is positioned downstream of FAK. Signals for HSC proliferation are transduced through FAK, PI3K, and Akt. Finally, expression of type I collagen is regulated by the PI3K-Akt signaling pathway...
- Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent Smad pathways: the role of Smad3Fuye Yang
Department of Medicine and Therapeutic, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
Hypertension 54:877-84. 2009..In conclusion, Ang II induces tubular CTGF expression and renal fibrosis via the TGF-beta-dependent and -independent Smad3 signaling pathways, suggesting that targeting Smad3 may have therapeutic potential for hypertensive nephropathy...
- Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1Markella Ponticos
Centre for Rheumatology, Department of Medicine, University College of London, United Kingdom
Mol Cell Biol 24:6151-61. 2004..b>Collagen type I is one of the most abundant of the ECM proteins...
- Bone marrow osteoblastic niche: a new model to study physiological regulation of megakaryopoiesisIsabella Pallotta
Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, USA
PLoS ONE 4:e8359. 2009....
- Effect of different femtosecond laser-firing patterns on collagen disruption during refractive lenticule extractionAndri K Riau
Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore
J Cataract Refract Surg 38:1467-75. 2012..To evaluate the changes in corneal collagen architecture subjected to different laser-firing patterns during refractive lenticule extraction...
- The phosphatidylinositol 3-kinase/Akt pathway enhances Smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-beta1Constance E Runyan
Department of Pediatrics, Northwestern University, Chicago, Illinois 60611, USA
J Biol Chem 279:2632-9. 2004..This cross-talk between the Smad and PI3K pathways likely contributes to TGF-beta1 induction of glomerular scarring...
- Differential effects of hyaluronan and its fragments on fibroblasts: relation to wound healingMaha David-Raoudi
Laboratory of Connective Tissue Biochemistry, Faculty of Medicine, Caen, France
Wound Repair Regen 16:274-87. 2008..Furthermore, the HA up-regulation of type III collagen and TGF-beta3 expression suggests that it may promote a fetal-like cell environment that favors scarless healing...
- Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signalingTaihao Quan
Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Am J Pathol 165:741-51. 2004..UV-induced down-regulation of TbetaRII, with attendant reduction of type I procollagen production, is a critical molecular mechanism in the pathophysiology of photoaging...
- Inhibition of type I procollagen production in photodamage: correlation between presence of high molecular weight collagen fragments and reduced procollagen synthesisJames Varani
Department of Pathology, The University of Michigan Medical School, 1301 Catherine Road Box 0602, Ann Arbor, MI 48109, U S A
J Invest Dermatol 119:122-9. 2002..As these fragments are processed further, there is less inhibition of type I procollagen production...
- Combined integrin phosphoproteomic analyses and small interfering RNA--based functional screening identify key regulators for cancer cell adhesion and migrationYanling Chen
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Cancer Res 69:3713-20. 2009..Altogether, we not only depict an integrin-modulated phosphorylation network during cell-ECM protein interactions but also reveal novel regulators for cell adhesion and migration...
- Relationships between serum adiponectin, leptin concentrations and bone mineral density, and bone biochemical markers in Chinese womenNan Wu
Institute of Endocrinology and Metabolism, Second Xiangya Hospital of Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, PR China corrected
Clin Chim Acta 411:771-5. 2010..However, their association with bone mineral density (BMD) is unknown. We investigated whether these serum adipocytokines concentrations are associated with BMD and bone turnover markers...
- Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosisXiao Mei Wang
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Exp Med 203:2895-906. 2006..This study indicates a pivotal role for cav-1 in ECM regulation and suggests a novel therapeutic target for patients with pulmonary fibrosis...
- TGF-beta-regulated collagen type I accumulation: role of Src-based signalsRangnath Mishra
Division of Nephrology, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
Am J Physiol Cell Physiol 292:C1361-9. 2007..Pharmacological inhibitors and a dominant negative Src mutant prevented the increase in collagen type I secretion in cells exposed to TGF-beta...
- Experimental murine myopia induces collagen type Iα1 (COL1A1) DNA methylation and altered COL1A1 messenger RNA expression in scleraXiangtian Zhou
School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
Mol Vis 18:1312-24. 2012....
- Physical properties of type I collagen extracted from fish scales of Pagrus major and Oreochromis niloticasToshiyuki Ikoma
Biomaterials Center, National Institute for Materials Science, Tsukuba, Ibaraki, Japan
Int J Biol Macromol 32:199-204. 2003..The enthalpy and entropy estimated from thermal analyses could be correlated to amino acid sequences (Gly-Pro-Hyp) of type I collagens and the number of methionine amino acid residues...
- Phenylbutyrate decreases type I collagen production in human lung fibroblastsDavid C Rishikof
The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Cell Biochem 91:740-8. 2004..These data suggest that PB regulates type I collagen expression in human lung fibroblasts by mechanisms that include cAMP production and histone acetylation. PB may have therapeutic use in fibrotic lung diseases...
- Interstitial fibrosis is associated with increased COL1A2 transcription in AA-injured renal tubular epithelial cells in vivoMaria Fragiadaki
Renal Section, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
Matrix Biol 30:396-403. 2011..Overall our study provides a better understanding into the expression patterns and roles of two major extracellular matrix proteins: type I collagen and CCN2...
- Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartmentSiham Sabri
Institut National de la Santé etde la Recherche Médicale INSERM, U790, Universite Paris XI, Institut Gustave Roussy, Villejut, France
Blood 108:134-40. 2006..In addition, they suggest a novel explanation for some of the platelet abnormalities characteristic of patients with WAS...
- Novel composite hyaluronan/type I collagen/fibrin scaffold enhances repair of osteochondral defect in rabbit kneeEva Filova
Department of Tissue Engineering, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
J Biomed Mater Res B Appl Biomater 87:415-24. 2008..The new composite scaffold containing collagen type I, hyaluronan, and fibrin, seeded with autologous chondrocytes and implanted into rabbit femoral trochlea, was ..
- Clusterin attenuates the development of renal fibrosisGwon Soo Jung
Department of Internal Medicine, Kyungpook National University School of Medicine, 50 Samdeok 2ga, Jung Gu, Daegu 700 721, South Korea
J Am Soc Nephrol 23:73-85. 2012..In conclusion, clusterin attenuates renal fibrosis in obstructive nephropathy. These results suggest that upregulation of clusterin during renal injury is a protective response against the development of renal fibrosis...
- Indoxyl sulphate inhibits osteoclast differentiation and functionAnaïs Mozar
INSERM ERI 12, EA4292, Amiens, France
Nephrol Dial Transplant 27:2176-81. 2012..Indeed, it was recently reported that IS induces skeletal resistance to parathyroid hormone in cultured osteoblastic cells. However, it is not yet known whether IS also affects osteoclast cells...
- Type I collagen receptor (alpha2beta1) signaling promotes prostate cancer invasion through RhoC GTPaseChristopher L Hall
Department of Urology, The University of Michigan, Ann Arbor, MI 48109 0940, USA
Neoplasia 10:797-803. 2008..We conclude that the ligation of alpha(2)beta(1) by collagen I activates RhoC guanosine triphosphatase, which mediates PCa invasion, and suggests a mechanism for the preferential metastasis of PCa cells within the bone...
- Collagen type I induces disruption of E-cadherin-mediated cell-cell contacts and promotes proliferation of pancreatic carcinoma cellsAlexander Koenig
Department of Internal Medicine I and Pathology, University of Ulm, Ulm, Germany
Cancer Res 66:4662-71. 2006..We show that collagen type I is able to initiate a disruption of the E-cadherin adhesion complex in pancreatic carcinoma cells...
- Artificial extracellular matrices composed of collagen I and sulfated hyaluronan with adsorbed transforming growth factor β1 promote collagen synthesis of human mesenchymal stromal cellsUte Hempel
Institute of Physiological Chemistry, Carl Gustav Carus Faculty of Medicine, Technische Universitat Dresden, Fiedlerstrasse 42, D 01307 Dresden, Germany
Acta Biomater 8:659-66. 2012..Thus, these aECM might be a useful tool for different tissue-engineering applications to enhance bone formation when used for biomaterial coating...
- Growth promoting substrates for human dermal fibroblasts provided by artificial extracellular matrices composed of collagen I and sulfated glycosaminoglycansAnja van der Smissen
Department of Dermatology, Venereology and Allergology, Leipzig University, Leipzig, Germany
Biomaterials 32:8938-46. 2011..Artificial ECM consisting of coll and high-sulfated GAGs proves to be a suitable biomaterial for dFb adhesion and proliferation that induces a "proliferative phenotype" of dFb found in the early stages of cutaneous wound healing...
- Myofibroblasts revert to an inactive phenotype during regression of liver fibrosisTatiana Kisseleva
Department of Medicine, School of Pharmacy, University of California, San Diego, CA 92093, USA
Proc Natl Acad Sci U S A 109:9448-53. 2012..Inactivation of HSCs was associated with up-regulation of the anti-apoptotic genes Hspa1a/b, which participate in the survival of HSCs in culture and in vivo...
- A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive ratsNerea Hermida
Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain
Cardiovasc Res 81:601-9. 2009..We investigated whether P144, a synthetic peptide from transforming growth factor-beta(1) (TGF-beta(1)) type III receptor betaglycan, exhibits cardiac antifibrotic properties...
- Dense type I collagen matrices that support cellular remodeling and microfabrication for studies of tumor angiogenesis and vasculogenesis in vitroValerie L Cross
Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
Biomaterials 31:8596-607. 2010....
- Loss of beta1-integrin enhances TGF-beta1-induced collagen expression in epithelial cells via increased alphavbeta3-integrin and Rac1 activityTomoko Hayashida
Division of Kidney Diseases, Department of Pediatrics, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Biol Chem 285:30741-51. 2010..Together, our results indicate that decreasing β1 chain causes αvβ3-integrin to become functionally dominant and promotes renal cell fibrogenesis via Rac1-mediated ERK activity...
- Caveolin-1 increases basal and TGF-beta1-induced expression of type I procollagen through PI-3 kinase/Akt/mTOR pathway in human dermal fibroblastsSangmin Kim
Department of Dermatology, Seoul National University College of Medicine, Republic of Korea
Cell Signal 20:1313-9. 2008....
- Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosisTatiana Kisseleva
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Hepatol 45:429-38. 2006..Hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis. However, their origin is still unknown. We tested the hypothesis that bone marrow (BM) contributes to the population of HSCs...
- Interplay between β1-integrin and Rho signaling regulates differential scattering and motility of pancreatic cancer cells by snail and Slug proteinsMario A Shields
Division of Hematology Oncology, Department of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Biol Chem 287:6218-29. 2012....
- Functionalisation of PLLA nanofiber scaffolds using a possible cooperative effect between collagen type I and BMP-2: impact on growth and osteogenic differentiation of human mesenchymal stem cellsMarkus D Schofer
Department of Orthopedics, University Hospital of Marburg, Baldingerstraße, 35043 Marburg, Germany
J Mater Sci Mater Med 22:1753-62. 2011..Matrices composed of PLLA-collagen type I or BMP-2 incorporated PLLA-collagen type I were seeded with human mesenchymal stem cells (hMSC) and ..
- Regulation of extracellular matrix genes by arecoline in primary gingival fibroblasts requires epithelial factorsG S Thangjam
Department of Molecular Reproduction Development and Genetics, Indian Institute of Science, Bangalore, India
J Periodontal Res 44:736-43. 2009..The basic aim of our study was to elucidate the mechanism underlying the action of arecoline on the expression of genes in oral fibroblasts...
- Contribution of bone marrow-derived cells to skin: collagen deposition and wound repairCarrie Fathke
Department of Surgery, Box 356410, University of Washington Medical Center, 1959 NE Pacific Street, Seattle 98195, USA
Stem Cells 22:812-22. 2004..matrix and transcribe both collagen types I and III, whereas the skin-resident cells transcribed only collagen type I. Whereas endothelial progenitor cells were found early during the wound repair process, bone marrow-derived ..
- Prediction of epigenetically regulated genes in breast cancer cell linesLeandro A Loss
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
BMC Bioinformatics 11:305. 2010..Finally, the methylation-expression associations are ranked through a logistic regression, and their significance is quantified through permutation analysis...
- Mechanical stimulation increases collagen type I and collagen type III gene expression of stem cell-collagen sponge constructs for patellar tendon repairNatalia Juncosa-Melvin
Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
Tissue Eng 13:1219-26. 2007..in culture, half of the stimulated and nonstimulated constructs were prepared to determine the expression of collagen type I, collagen type III, decorin, fibronectin, and glyceraldehyde-3-phosphate dehydrogenase genes using real-time ..
- Mechanical properties of single electrospun collagen type I fibersLanti Yang
Polymer Chemistry and Biomaterials, Faculty of Science and Technology and Institute for Biomedical Technology BMTI, University of Twente, P O Box 217, 7500 AE, Enschede, The Netherlands
Biomaterials 29:955-62. 2008..Cross-linking of the electrospun fibers with glutaraldehyde vapor increased the shear modulus of the fiber from approximately 30 to approximately 50 MPa at ambient conditions...
- Suppression of type I collagen production by microRNA-29b in cultured human stellate cellsTomohiro Ogawa
Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Biochem Biophys Res Commun 391:316-21. 2010..It is anticipated that miR-29b will be used for the regulation of stellate cell activation and lead to antifibrotic therapy...
- Mutations in PPIB (cyclophilin B) delay type I procollagen chain association and result in perinatal lethal to moderate osteogenesis imperfecta phenotypesShawna M Pyott
Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
Hum Mol Genet 20:1595-609. 2011....
- Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGF-beta2 in human retinal pigment epithelial cellsYuji Itoh
Department of Ophthalmology, Oita University, Hasama machi, Yufu shi Oita 879 5593, Japan
Exp Eye Res 84:464-72. 2007..The RhoA/Rho-kinase pathway may be a therapeutic target for treating PVR...
- Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cellsZixue Jin
Institute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, China
Hepatology 53:219-29. 2011..The inflammatory cytokines IL-4 and IL-13 produced by NKT cells played a pivotal role in HSCs activation in an in vitro coculture experiment...
- COL1A1 and COL2A1 genes and myopia susceptibility: evidence of association and suggestive linkage to the COL2A1 locusRavikanth Metlapally
Center for Human Genetics, North Carolina, USA
Invest Ophthalmol Vis Sci 50:4080-6. 2009..This study was conducted to investigate whether these collagen genes are associated and/or genetically linked with myopia in large Caucasian family datasets...
- Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activationFeng Hong
Mount Sinai School of Medicine, New York, NY 10029, USA
Hepatology 49:2055-67. 2009..Inhibitor studies suggest that SDF-1alpha/CXCR4-dependent extracellular signal-regulated kinase 1/2 and Akt phosphorylation mediate effects on collagen I expression and stellate cell proliferation...
- Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosisGuntram A Grassl
Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
Gastroenterology 134:768-80. 2008..Here, we present a novel murine model of severe and persistent intestinal fibrosis caused by chronic bacterial-induced colitis...
- Oxidative stress mediates cardiac fibrosis by enhancing transforming growth factor-beta1 in hypertensive ratsWenyuan Zhao
Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, 956 Court Avenue Rm B310, Memphis, TN, 38163, USA
Mol Cell Biochem 317:43-50. 2008..Thus, cardiac oxidative stress promotes the development of cardiac fibrosis by upregulating TGF-beta1 expression, which subsequently enhances cardiac collagen synthesis and suppresses collagen degradation in hypertensive rats...
- Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell-like propertyR Salingcarnboriboon
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Exp Cell Res 287:289-300. 2003..These observations indicated that the established tendon cell line possesses mesenchymal stem cell-like properties, suggesting the existence of mesenchymal stem cell in tendon tissue...
- Enhanced biological stability of collagen porous scaffolds by using amino acids as novel cross-linking bridgesLie Ma
Department of Polymer Science and Engineering, Zhejiang University, No 38, Zheda Road, Hangzhou, Zhejiang 310027, China
Biomaterials 25:2997-3004. 2004..Preliminary in vitro culture of fibroblasts in the collagen scaffold cross-linked with EDAC/NHS in the presence of lysine has shown that the original good cytocompatibility of collagen was retained...
- Smad3 mediates the TGF-beta-induced contraction of type I collagen gels by mouse embryo fibroblastsXiangde Liu
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5125, USA
Cell Motil Cytoskeleton 54:248-53. 2003..Thus, the Smad3 gene could be a target for blocking contraction of fibrotic tissue induced by TGF-beta...
- Membrane type 1 matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-related kinase activation and cell migrationTakahisa Takino
Department of Molecular Virology and Oncology and Cell Cycle Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
Cancer Res 64:1044-9. 2004..Thus, adhesion of HT1080 cells to type I collagen induces MT1-MMP-dependent ERK activation, which in turn causes an increase in MT1-MMP levels and subsequent cell migration...
- PKCalpha mediates CCL18-stimulated collagen production in pulmonary fibroblastsIrina G Luzina
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Am J Respir Cell Mol Biol 35:298-305. 2006..These observations suggest that in primary pulmonary fibroblasts, PKCalpha but not PKCdelta or PKCepsilon mediate the profibrotic effect of CCL18. PKCalpha may therefore become a viable target for future antifibrotic therapies...
- Early response of alpha2(I) collagen to acetaldehyde in human hepatic stellate cells is TGF-beta independentGianluca Svegliati-Baroni
Clinica di Gastroenterologia, Universita Politecnica delle Marche, Ancona, Italy
Hepatology 42:343-52. 2005..We suggest that early acetaldehyde-dependent events induce the late expression of TGF-beta1 and create an H(2)O(2)-dependent autocrine loop that may sustain and amplify the fibrogenic response of this alcohol metabolite...
- Type I collagen synthesis and degradation in peritendinous tissue after exercise determined by microdialysis in humansH Langberg
Sports Medicine Research Unit, Department of Rheumatology H and Department of Clinical Physiology, Bispebjerg Hospital, Copenhagen, Denmark
J Physiol 521:299-306. 1999..This suggests an adaptation to acute physical loading also in non-bone-related collagen in humans...
- Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthmaSukhvinder S Sidhu
Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 107:14170-5. 2010..Epithelial cell-derived periostin in asthma has roles in TGF-beta activation and collagen gel elasticity in asthma...
- Identification of novel target genes by an epigenetic reactivation screen of renal cancerInmaculada Ibanez de Caceres
Departments of Surgical Oncology and Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Cancer Res 66:5021-8. 2006....
- Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2Elvira Olaso
Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 277:3606-13. 2002..These data establish a role for DDR2 in critical events during wound repair...
- Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosisHiroyuki Higashiyama
Pharmacology Department, Tsukuba Research Laboratories, GlaxoSmithKline KK, 43 Wadai, Tsukuba, Ibaraki, 300 4247, Japan
Exp Mol Pathol 83:39-46. 2007..These results suggest that ALK5 inhibition attenuates R-Smads activation thereby attenuates pulmonary fibrosis...
- Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2Surabhi Dangi-Garimella
Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Cancer Res 71:1019-28. 2011....
- Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary glandWendy V Ingman
Department of Molecular and Developmental Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Dev Dyn 235:3222-9. 2006..Macrophage deficiency also caused terminal end buds to be rounder and shorter. These studies reveal a role for macrophages in collagen fibrillogenesis and in organization of the structure of terminal end buds...
- The mechanical memory of lung myofibroblastsJenna L Balestrini
Laboratory of Tissue Repair and Regeneration, Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Fitzgerald Building, Room 234, 150 College Street, Toronto, ON M5S3E2, Canada
Integr Biol (Camb) 4:410-21. 2012..This priming effect has important implications for the progression and persistence of aggressive fibrotic diseases such as idiopathic pulmonary fibrosis...
- Modeling and quantification of cancer cell invasion through collagen type I matricesOlivier De Wever
Laboratory of Experimental Cancer Research, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, Gent, Belgium
Int J Dev Biol 54:887-96. 2010..Initiation and monitoring of the single-cell and spheroid invasion model can be achieved in 8 h (over 3 days) and in 14 h (over 8 days) respectively...
- Hereditary dentin defectsJ W Kim
Seoul National University, School of Dentistry Department of Pediatric Dentistry and Dental Research Institute, 28 2 Yongon Dong, Chongno Gu, Seoul, Korea 110 749
J Dent Res 86:392-9. 2007....
- Alteration of activity and survival of osteoblasts obtained from human periodontitis patients: role of TRAILG Mori
Department of Human Anatomy and Histology, University of Bari, Italy
J Biol Regul Homeost Agents 21:105-14. 2007..In particular, the alkaline phosphatase activity and the collagen type I production, as well as the formation of mineralized nodules, typical markers of differentiated OBs, were ..
- Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblastsYoshihide Asano
Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
J Immunol 175:7708-18. 2005..These results suggest that the up-regulated expression of alpha(v)beta3 contributes to the establishment of autocrine TGF-beta loop in scleroderma fibroblasts, and this integrin is a potent target for the treatment of scleroderma...
- Effect of IGF-I and PDGF administered in vivo on the expression of osteoblast-related genes in old ratsH Tanaka
Department of Orthopedic Surgery, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Japan
J Endocrinol 174:63-70. 2002....
- Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligationJing Lin Xia
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Am J Pathol 168:1500-12. 2006..HGF abolished the phenotypic conversion of biliary epithelial cells induced by TGF-beta1. These results suggest that HGF ameliorates hepatic biliary fibrosis in part by blocking bile duct epithelial to mesenchymal transition...
- Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosisHong Xia
Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
J Exp Med 205:1659-72. 2008..These results provide direct evidence for defective negative regulation of the proliferative pathway in IPF fibroblasts and support the theory that the pathogenesis of IPF involves an intrinsic fibroblast defect...
- Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cellsHideaki Sowa
Third Department of Medicine, Kobe University School of Medicine, Japan
J Bone Miner Res 17:1190-9. 2002..We propose that Smad3 plays an important role in osteoblastic bone formation and might help to elucidate the transcriptional mechanism of bone formation and possibly lead to the development of bone-forming drugs...
- Null mutations in LEPRE1 and CRTAP cause severe recessive osteogenesis imperfectaJoan C Marini
Bone and Extracellular Matrix Branch, NICHD, NIH, Bethesda, MD 20892, USA
Cell Tissue Res 339:59-70. 2010....
- The linker region of Smad2 mediates TGF-beta-dependent ERK2-induced collagen synthesisFengfeng Li
Department of Orthopaedics, The Sixth Affiliated People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200233, China
Biochem Biophys Res Commun 386:289-93. 2009..These results indicate that ERK2, rather than ERK1, plays a predominantly positive role in TGF-beta1-induced collagen synthesis, and that ERK2 enhances collagen synthesis, at least partially, through activation of the Smad2 linker site...
- The effects of enamel matrix derivative (EMD) on osteoblastic cells in culture and bone regeneration in a rat skull defectSatoshi Yoneda
Masticatory Function Control, Tokyo Medical and Dental University, Yushima, Tokyo, Japan
J Periodontal Res 38:333-42. 2003..Enamel matrix derivative (EMD) has been clinically used to promote periodontal tissue regeneration. The purpose of the present study is to clarify EMD affects on osteoblastic cells and bone regeneration...
- Imbalance in the synthesis of collagen type I and collagen type III in smooth muscle cells derived from human varicose veinsP Sansilvestri-Morel
Division of Angiology, Servier Research Institute, Suresnes, France
J Vasc Res 38:560-8. 2001..An imbalance between the synthesis of collagen type I protein (collagen I) and collagen type III protein (collagen III) could explain the lack of elasticity of ..
- Prostaglandin E(2) inhibits collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2 receptor and cAMP signalingSteven Huang
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Am J Physiol Lung Cell Mol Physiol 292:L405-13. 2007..Our data indicate that PGE(2) inhibits fibroblast activation in primary lung fibroblasts via binding of EP2 receptor and production of cAMP; inhibition of collagen I proceeds via activation of PKA...
- Defective collagen crosslinking in bone, but not in ligament or cartilage, in Bruck syndrome: indications for a bone-specific telopeptide lysyl hydroxylase on chromosome 17R A Bank
Gaubius Laboratory TNO Prevention and Health, Division of Vascular and Connective Tissue Research, P O Box 2215, 2301 CE Leiden, The Netherlands
Proc Natl Acad Sci U S A 96:1054-8. 1999..We report that lysine residues within the telopeptides of collagen type I in bone are underhydroxylated, leading to aberrant crosslinking, but that the lysine residues in the triple ..
- Zoledronic acid and survival in breast cancer patients with bone metastases and elevated markers of osteoclast activityAllan Lipton
Milton S Hershey Medical Center, Penn State Cancer Institute, 500 University Drive, Hershey, Pennsylvania 17033, USA
Oncologist 12:1035-43. 2007....
- Homozygosity for a missense mutation in SERPINH1, which encodes the collagen chaperone protein HSP47, results in severe recessive osteogenesis imperfectaHelena E Christiansen
Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA
Am J Hum Genet 86:389-98. 2010..Identification of this mutation in SERPINH1 gives further insight into critical steps of the collagen biosynthetic pathway and the molecular pathogenesis of OI...
- Differential regulation of actin stress fiber assembly and proplatelet formation by alpha2beta1 integrin and GPVI in human megakaryocytesSiham Sabri
Institut National de la Sante et de la Recherche Medicale, U362, Institut Gustave Roussy, rue Camille Desmoulins, 94800 Villejuif, France
Blood 104:3117-25. 2004..In the marrow microenvironment, mature MKs are in contact with the extracellular matrix, including fibrillar collagen type I. MKs express alpha2beta1 integrin and the immunoglobulin superfamily member glycoprotein VI (GPVI), the main ..
- Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9Azuma Watanabe
Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA
Hepatology 46:1509-18. 2007..Stimulation of TLR9 on HSCs blocked signaling by the PDGF signaling molecule inositol 1,4,5-triphosphate and reduced PDGF-mediated increase in cytosolic Ca(2+)...
- Enhanced bronchial expression of extracellular matrix proteins in chronic obstructive pulmonary diseaseAndor R Kranenburg
Department of Pharmacology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
Am J Clin Pathol 126:725-35. 2006..Our data suggest that COPD exhibits increased bronchial deposition of ECM proteins that contribute to deteriorated lung function and airway remodeling...
- Hematopoietic Stem Cell Transplantation in Osteogenesis ImperfectaMeenal Mehrotra; Fiscal Year: 2012..Long term, these findings have the potential to identify HSC transplantation, and not the transplantation of MSCs or progenitor cells, as the therapy of choice for this collagen disorder. ..
- Conditional Knockout of Calcium Receptors in Bone CellsDolores M Shoback; Fiscal Year: 2013....
- Pluripotent human stem cells as models for normal and diseased trophoblastROBERT MICHAEL ROBERTS; Fiscal Year: 2013..Also by generating such pluripotent cells from umbilical cords of babies born to mothers that developed pre-eclampsia, we hope to recreate the cell type that caused the disease in the first place. ..
- PTH-RELATED PEPTIDE AND VIT D IN PROSTATE CANCER GROWTHMiriam Falzon; Fiscal Year: 2009..matrix proteins collagen types I and IV, laminin, and fibronectin;(c) migration onto laminin and collagen type I;(d) invasion of Matrigel, a reconstituted basement membrane;(e) anchorage-independent cell growth;(f) cell ..
- MECHANISM OF RETROCORNEAL FIBROUS MEMBRANEEunDuck P Kay; Fiscal Year: 2010..Such detailed information is crucial for targeting the specific stage and specific pathway before inflammation causes an irreversible EMT. ..
- 3D human skin modelsMeenhard Herlyn; Fiscal Year: 2010..and, optionally, also endothelial, smooth muscle, and inflammatory, and immune cells that are all embedded in collagen type I;2) 'epidermis'consisting of multilayered keratinocytes at distinct differentiation stages and ..
- Suppression of Collagen Induced Arthritis with Altered Peptide LigandsAndrew H Kang; Fiscal Year: 2010..Other peptidesef that a definitive understanding of the mechanism(s) through which A9 suppresses arthritis will facilitate the development of improved treatments for RA. ..
- Effect of botulinum toxin plus vibration on bone in children with cerebral palsyChristopher M Modlesky; Fiscal Year: 2012....
- Leads and Target Validation for Vascular Calcification in Chronic Kidney DiseaseJose Luis Millan; Fiscal Year: 2010..Our studies will validate a therapeutic target for medial calcification and will optimize new lead chemicals to prevent/treat arterial calcification in established animal models, thus filling this unmet clinical need. ..
- Cathespin K Radioligands for In Vivo ImagingMichael R Kilbourn; Fiscal Year: 2012....
- Assessing the Impact of Osteogenesis Imperfecta on Non-Skeletal SystemsLaura Tosi; Fiscal Year: 2012....
- The role of TNF-Alpha in cutaneous integrityVictoria P Werth; Fiscal Year: 2013..This information will facilitate evaluation and development of potential interventions to prevent these extensive and destructive changes in skin. ..
- Invasive Behavior of Tumor Cells Producing Collagenase-1Constance E Brinckerhoff; Fiscal Year: 2013..Inhibiting MMP-1 gene expression may, therefore, be useful in therapeutically controlling melanoma metastasis. ..
- Optimizing Normal Collagen Replacement in Osteogenesis ImperfectaSarah L Dallas; Fiscal Year: 2013..These studies have the potential to lead to novel or improved treatments for patients with OI. ..
- The FIAT-ATF4 interaction and the control of bone massRene St Arnaud; Fiscal Year: 2010..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
- Modeling Dentin by G Protein Coupled Receptor SignalingOrapin V Horst; Fiscal Year: 2013..Horst's natural progression from current research experiences to the mentored clinical scientist development phase and then to independence. ..
- HORMONAL REGULATION OF ETHANOL METABOLISMEsteban Mezey; Fiscal Year: 2011..Furthermore, the role of oxidant stress and nitric oxide as mediators of the activating effect of TGFalpha and acetaldehyde on the human alpha1 (I) collagen promoter will be investigated. ..
- Transforming Growth Factor-Beta (TGF-b) Signaling in Aged SkinTaihao Quan; Fiscal Year: 2013..This hypothesis is novel because it focuses on the importance of the extracellular matrix, rather than inherent cellular deficits, as a driving force for the aging process in humans. ..
- Identification of a novel population in the adult bone marrowErnestina Schipani; Fiscal Year: 2012..The accomplishment of the experiments described in Aims I and II will likely expand our knowledge on the pathogenesis of bone marrow fibrosis, at least in a context of chronic activation of the PTH receptor. ..
- Translation Regulation of Collagen-1 in Liver Fibrosis: Target of Drug DiscoveryZarko Manojlovic; Fiscal Year: 2013....
- Combinatorial Metal Oxide Substrates to Enhance Osteogenic Stem Cell FunctionsJaime E Ramírez-Vick; Fiscal Year: 2012..Aim 2: Determine the type, distribution and conformation of select serum and/or ECM adhesive proteins such as collagen type I, fibronectin, laminin, and vitronectin, adsorbed onto the novel material substrates prepared by the research ..
- Role of Surface Roughness in Regulating Tumor Cell BehaviorSarah C Glover; Fiscal Year: 2012....
- Targeted Correction of Dominant Mutations of Type I Collagen Causing Severe OIDavid W Rowe; Fiscal Year: 2013....
- MECHANISMS OF POLARIZED SECRETION BY BONE CELLSSteven L Teitelbaum; Fiscal Year: 2013..Additionally Syt VII regulates OB exocytosis. Hence, our specific aims are to determine the mechanisms by which 1) PKC;signaling promotes OC polarization and 2) synaptotagmin VII controls exocytosis by OCs and OBs. ..
- Apoptosis and FibrosisARIEL R JOHNSON; Fiscal Year: 2013..One characteristic of fibrosis is an increase in the synthesis of collagen type I (COL1) and decreases in both synthesis of COL3 and degradation of COL1...
- Osteoblast and Odontoblast Specific Regulatory Action of Runx2 for Bone and ToothMITRA D ADHAMI; Fiscal Year: 2013..Eventually, the proposed studies will facilitate the development of novel diagnostic tools and therapeutic treatments regarding dentin matrix malformations, skeletal abnormalities, and craniofacial dysplasias. ..
- DYNAMICS OF ASSEMBLY OF BONE MATRIX PROTEINSSarah L Dallas; Fiscal Year: 2013..As these studies will significantly advance our mechanistic understanding the process of bone formation, the research has implications for treatment of osteoporosis, osteogenesis imperfecta and metabolic bone diseases. ..
- Targeting myofibroblast activation in chronic fibrotic diseaseARTHUR ROGER STRAUCH; Fiscal Year: 2011..abstract_text> ..
- PET Imaging of Pulmonary FibrosisPETER D CARAVAN; Fiscal Year: 2013..End of Abstract) ..
- Regulated expression of B. burgdorferi virulence genesFELIPE CARDENAS CABELLO; Fiscal Year: 2010..burgdorferi. These tools will be used to identify genes that are potentially responsible for this organism's virulence and which could be targets for new vaccines and antibiotics against Lyme disease. ..
- Regulation of Type I Collagen in Hepatic FibrosisBranko Stefanovic; Fiscal Year: 2012..The results will elucidate this unique mechanism of collagen synthesis in HSCs and identify the regulatory roles of the factors involved, as potential targets for development of antifibrotic drugs. ..
- Peri-arteriolar Myofibroblast Differentiation in the Pathobiology of IPAHARTHUR ROGER STRAUCH; Fiscal Year: 2012..abstract_text> ..
- Optimization of Efficacy and Safety Pharamacology of Fibrosis Imaging Agent CM-65ANDREW FRANCIS KOLODZIEJ; Fiscal Year: 2013..The ability of this development candidate to noninvasively stage fibrosis by MRI will be fully evaluated in two orthogonal animal models of disease. ..
- GENE TARGETING STRATEGIES FOR THE TREATMENT OF OSTEOGENESIS IMPERFECTADavid W Russell; Fiscal Year: 2010..The research will also have broader implications, since gene targeting methods for human MSCs could potentially be applied to many diseases of bone, cartilage, muscle, and possibly other tissues. ..
- Regulation of Extracellular Matrix Homeostatsis in Skin AgingGary J Fisher; Fiscal Year: 2013..abstract_text> ..
- Role of IGF-1 and Estrogen in Skeletal Anabolic Response to LoadingChandrasekhar Kesavan; Fiscal Year: 2011..Our understanding of the role of IGF-I and estrogen in mediating bone formation response to loading will lead to development of strategies to increase bone anabolic response to ML by modulating local IGF-I actions in bone. ..
- MMP14-dependent regulation of adipose tissue remodeling and function (R01)Tae Hwa Chun; Fiscal Year: 2013..The knowledge will help us understand the pathogenesis of insulin resistance and obesity-related metabolic diseases from the perspective of peri-adipocyte collagen turnover. ..
- Flow Perfusion Bioreactor Fabrication of Bioactive Polymer/ECM Hybrid ConstructsAntonios G Mikos; Fiscal Year: 2013..g., collagen type I for bone and collagen type II for cartilage)...
- Peptide therapeutics for inhibiting abdominal adhesionsCYNTHIA ELLEN LANDER; Fiscal Year: 2012..MK2 is implicated in the connective tissue growth factor (CTGF) and collagen type I up regulation that promotes adhesions...
- Fibrosis-Protease Cross-Talk Regulating Pancreatic Cancer InvasionHidayatullah G Munshi; Fiscal Year: 2013..abstract_text> ..
- Role of Fox03a in Regulating the IPF Fibroblast PhenotypeRICHARD S NHO; Fiscal Year: 2010..Identifying key regulatory nodes controlling the pathologic behavior of IPF fibroblasts may provide molecular therapeutic targets to limit the progressive fibrosis that characterizes IPF. ..
- Molecular Mechanisms by which TNFalpha Modulates FibrosisDavid A Brenner; Fiscal Year: 2013..This proposal uses the wound healing model of hepatic fibrosis to assess how TNF? modulates wound healing through different signal transduction pathways in the whole organism and in specific hepatic cell populations. ..
- A Role of Novel Serpin Maspinin Prostate Tumor/Bone InteractionShijie Sheng; Fiscal Year: 2012..The expected results are likely to shed new lights on how to improve the therapeutic intervention of PC bone metastasis. ..
- DYNAMICS OF ASSEMBLY OF BONE MATRIX PROTEINSSARAH DALLAS; Fiscal Year: 2009..abstract_text> ..
- Does increasing bone mass also increase bone strength in mouse models of OI?Matthew L Warman; Fiscal Year: 2012..Ultimately this knowledge will determine whether modulators of the LRP5/6 signaling pathway, or other therapies that are anabolic in wild-type bone, can be used to improve bone properties in human patients who have OI. ..
- Function of epithelial-mesenchymal transition during pulmonary fibrosisKEVIN KEEWOUN KIM; Fiscal Year: 2013..These studies will help define previously unexplored mechanisms that may regulate fibrosis with the potential of designing new and better therapies. ..
- Role of Acetaldehyde on PDGF-BB-induced HSC Migration and Proliferation.Raj M Lakshman; Fiscal Year: 2011..Our long term goal is to unravel key molecular events triggered by acetaldehyde that could lead to therapeutic intervention and thus, to prevention and/or amelioration of alcohol-induced liver fibrosis and cirrhosis. ..
- Bcl-2, A Key Factor for Dentinogenesis and Tooth Damage RepairWenjian Zhang; Fiscal Year: 2010..It is expected to generate new interventions to preserving the vitality and functions of teeth injured by infections or trauma, and contributing to fabricated teeth via bioengineering. ..
- Alcohol-induced liver fibrosis:an in vitro modelRaj M Lakshman; Fiscal Year: 2012..These studies have the potential to yield novel therapeutic modalities to treat or ameliorate this disease. ..
- Origins of Elasticity and Viscoelasticity in LigamentsJeffrey A Weiss; Fiscal Year: 2013....
- DEVELOPMENT OF AN IN VITRO WOUND HEALING MODELFrederick Grinnell; Fiscal Year: 2012..Indeed, the general usefulness of 3D matrix models to accelerate a wide range of translational research work increasingly has been recognized. ..
- The Importance of Prolyl 3-hydroxylation in recessive Osteogenesis ImperfectaERICA PAIGE HOMAN; Fiscal Year: 2013..abstract_text> ..
- The mechanism of a Chinese herbal formula on cancer painLing Xu; Fiscal Year: 2012..This study will evaluate the effects and mechanisms of an herb formula Tongluo Sanjie (TLSJ) on such pain in rat models. The success of the proposed study will greatly advance the management of cancer pain. ..
- Uveitogenic Epitope(s) and Idiopathic Anterior UveitisNalini S Bora; Fiscal Year: 2013..Additionally, these studies will facilitate the development of antigen based therapeutic interventions for human IAU which is associated with significant morbidity. ..
- Treating Alcoholic Liver Fibrosis by Reversal of Type I CollagenKun Cheng; Fiscal Year: 2010..Successful accomplishment of this project will provide an effective therapeutics to treat alcoholic liver fibrosis by inducing degradation of the accumulated type I collagen. ..
- Bone Sialprotein in Osteogenesis and Bone RegenerationJinxi Wang; Fiscal Year: 2013..Specific Aim 3 will identify BSP-specific osteogenic activities for the repair of cranial defects. ..
- NON-PARENCHYMAL LIVER CELL COREHidekazu Tsukamoto; Fiscal Year: 2013..New information generated by these studies with support from the core, will lead to identification of new treatment modalities for the diseases. ..
- Sclerostin Antibody Therapy for Treatment of Osteogenesis ImperfectaKenneth M Kozloff; Fiscal Year: 2013....
- Growth Factors;Effect on Aspects of Bone FormationErnesto Canalis; Fiscal Year: 2012..These investigations should clarify the role of Nov in bone cell function, and its interactions with BMP and Wnt signaling pathways. ..
- Extracellular matrix remodeling and fibrosisJANE M SOTTILE; Fiscal Year: 2013..polymerizing) FN into the ECM regulates the deposition and stability of other ECM molecules, including collagen type I. In addition, agents that we and others have used to inhibit FN polymerization, such as the peptide pUR4, ..
- Targeting the Lrp5 Pathway To Increase Bone Strength In Osteogenesis ImperfectaCHRISTINA MARIE JACOBSEN; Fiscal Year: 2013..Finally, using a mouse OI model, I will identify therapeutic strategies that best improve bone properties while minimizing the side effects of therapy. ..
- New In Vitro Human Liver Toxicity Bioassay SystemRaj K Singh; Fiscal Year: 2013..VBI will develop a market-ready 3D-liver assay platform adaptable to HTS applications. Sale of 3D HuBiogel culture kits or in-house bioassay services would have significant world-wide market, as a research &diagnostic tool. ..
- CELL AND GENE THERAPY IN A MOUSE MODEL OF HUMAN OSTEOGENChristopher Niyibizi; Fiscal Year: 2000..abstract_text> ..
- COLLAGEN GENE EXPRESSION DURING SCLERAL MATURATIONMARK ZORN; Fiscal Year: 1991..Collagen type III is less able to resist stretch than is collagen type I. The amount of collagen type III relative to collagen type I decreases as the eye matures...
- MUTATION IDENTIFICATION IN HERITABLE CHONDRODYSTROPHIESDeborah Redford Badwal; Fiscal Year: 1993..The strategy should be applicable to defining mutations of any gene that is expressed in cartilage and provide an avenue for understanding the molecular basis of this extremely heterogeneous group of heritable disorders...
- Investigating Ultrastructural Collagen Changes in Osteogenesis ImperfectaJoseph Wallace; Fiscal Year: 2009..Therefore, this research is not only applicable to Ol patients, but has broader implications for investigating other diseases related to ultrastructural modifications of bone. ..
- Multiscale structural and mechanical analysis of soft tissue under complex loadsSPENCER PARK LAKE; Fiscal Year: 2012..two scales directly, was recently applied successfully to evaluate biaxial tensile testing of cell-seeded collagen Type I gels (tissue- equivalents, or TEs)...
- CYR61-a novel potential mediator of photoaged human skinTaihao Quan; Fiscal Year: 2010..Results from the proposed studies will provide a foundation of knowledge regarding the role of CYR61 in human skin. ..
- Inhibition of Collagen Synthesis by RNA InterferenceKyonggeun Yoon; Fiscal Year: 2003....
- EVALUATION OF CELLULAR GENE THERAPY FOR OIChristopher Niyibizi; Fiscal Year: 2001....
- GROWTH FACTOR SIGNALING AND TRAFFIC IN ANGIOGENESISIgor Prudovsky; Fiscal Year: 2005..abstract_text> ..
- Idiopathic Anterior Uveitis and Type I CollagenNALINI BORA; Fiscal Year: 2009..These observations should also allow the development of effective therapy based on selective antigen specific modulation of the immune response in the treatment of this disease. ..
- Using gold nanorods to modify the extracellular matrix and mechanical propertiesEdie C Goldsmith; Fiscal Year: 2010..Of the ECM proteins present, collagen type I is particularly important because it is responsible for the structural support and mechanical durability of ..
- FOLLICULAR EXPRESSION OF COLLAGEN I DURING ERUPTIONBhavna Shroff; Fiscal Year: 1991..These two specific aims will be tested during a one year period to collect preliminary datas essential to the further understanding of the mechanism of tooth eruption and its regulation...