cellulose

Summary

Summary: A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.

Top Publications

  1. pmc Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components
    R Jason Quinlan
    Novozymes, Inc, Davis, CA 95618, USA
    Proc Natl Acad Sci U S A 108:15079-84. 2011
  2. ncbi Metagenomic and functional analysis of hindgut microbiota of a wood-feeding higher termite
    Falk Warnecke
    DOE Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, California 94598, USA
    Nature 450:560-5. 2007
  3. ncbi Cellulose synthesis in higher plants
    Chris Somerville
    Department of Plant Biology, Carnegie Institution, and Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Annu Rev Cell Dev Biol 22:53-78. 2006
  4. pmc Identification of genes required for cellulose synthesis by regression analysis of public microarray data sets
    Staffan Persson
    Department of Plant Biology, Carnegie Institution, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:8633-8. 2005
  5. pmc Evidence of cellulose metabolism by the giant panda gut microbiome
    Lifeng Zhu
    Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China and China Wildlife Conservation Association, Beijing 100714, China
    Proc Natl Acad Sci U S A 108:17714-9. 2011
  6. doi Cellulosic biofuels
    Andrew Carroll
    Department of Biology, Stanford University, Stanford, California 94305, USA
    Annu Rev Plant Biol 60:165-82. 2009
  7. ncbi Features of promising technologies for pretreatment of lignocellulosic biomass
    Nathan Mosier
    Laboratory of Renewable Resources Engineering, Department of Agricultural and Biological Engineering, Purdue University, Potter Engineering Center, 500 Central Drive, West Lafayette, IN 47907 2022, USA
    Bioresour Technol 96:673-86. 2005
  8. ncbi Visualization of cellulose synthase demonstrates functional association with microtubules
    Alexander R Paredez
    Department of Biological Sciences, Stanford University, 260 Panama Street, Stanford, CA 94305, USA
    Science 312:1491-5. 2006
  9. ncbi Biomass recalcitrance: engineering plants and enzymes for biofuels production
    Michael E Himmel
    Chemical and Biosciences Center, National Renewable Energy Laboratory, Golden, CO 80401, USA
    Science 315:804-7. 2007
  10. ncbi Toward an aggregated understanding of enzymatic hydrolysis of cellulose: noncomplexed cellulase systems
    Yi Heng Percival Zhang
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Biotechnol Bioeng 88:797-824. 2004

Detail Information

Publications423 found, 100 shown here

  1. pmc Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components
    R Jason Quinlan
    Novozymes, Inc, Davis, CA 95618, USA
    Proc Natl Acad Sci U S A 108:15079-84. 2011
    ....
  2. ncbi Metagenomic and functional analysis of hindgut microbiota of a wood-feeding higher termite
    Falk Warnecke
    DOE Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, California 94598, USA
    Nature 450:560-5. 2007
    ..Only recently have data supported any direct role for the symbiotic bacteria in the gut of the termite in cellulose and xylan hydrolysis...
  3. ncbi Cellulose synthesis in higher plants
    Chris Somerville
    Department of Plant Biology, Carnegie Institution, and Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Annu Rev Cell Dev Biol 22:53-78. 2006
    b>Cellulose microfibrils play essential roles in the organization of plant cell walls, thereby allowing a growth habit based on turgor...
  4. pmc Identification of genes required for cellulose synthesis by regression analysis of public microarray data sets
    Staffan Persson
    Department of Plant Biology, Carnegie Institution, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:8633-8. 2005
    ..To identify factors involved in cellulose biosynthesis, we used a regression method to analyze 408 publicly available Affymetrix Arabidopsis microarrays...
  5. pmc Evidence of cellulose metabolism by the giant panda gut microbiome
    Lifeng Zhu
    Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China and China Wildlife Conservation Association, Beijing 100714, China
    Proc Natl Acad Sci U S A 108:17714-9. 2011
    ..necessary enzymes associated with a carnivorous digestive system but lacks genes for enzymes needed to digest cellulose, the principal component of their bamboo diet...
  6. doi Cellulosic biofuels
    Andrew Carroll
    Department of Biology, Stanford University, Stanford, California 94305, USA
    Annu Rev Plant Biol 60:165-82. 2009
    ..This review describes the major topics of enquiry concerning cellulosic biofuels with an emphasis on those areas of research and development that include research problems of interest to plant biologists...
  7. ncbi Features of promising technologies for pretreatment of lignocellulosic biomass
    Nathan Mosier
    Laboratory of Renewable Resources Engineering, Department of Agricultural and Biological Engineering, Purdue University, Potter Engineering Center, 500 Central Drive, West Lafayette, IN 47907 2022, USA
    Bioresour Technol 96:673-86. 2005
    ..Many physio-chemical structural and compositional factors hinder the enzymatic digestibility of cellulose present in lignocellulosic biomass...
  8. ncbi Visualization of cellulose synthase demonstrates functional association with microtubules
    Alexander R Paredez
    Department of Biological Sciences, Stanford University, 260 Panama Street, Stanford, CA 94305, USA
    Science 312:1491-5. 2006
    Expression of a functional yellow fluorescent protein fusion to cellulose synthase (CESA) in transgenic Arabidopsis plants allowed the process of cellulose deposition to be visualized in living cells...
  9. ncbi Biomass recalcitrance: engineering plants and enzymes for biofuels production
    Michael E Himmel
    Chemical and Biosciences Center, National Renewable Energy Laboratory, Golden, CO 80401, USA
    Science 315:804-7. 2007
    ..To achieve sustainable energy production, it will be necessary to overcome the chemical and structural properties that have evolved in biomass to prevent its disassembly...
  10. ncbi Toward an aggregated understanding of enzymatic hydrolysis of cellulose: noncomplexed cellulase systems
    Yi Heng Percival Zhang
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Biotechnol Bioeng 88:797-824. 2004
    Information pertaining to enzymatic hydrolysis of cellulose by noncomplexed cellulase enzyme systems is reviewed with a particular emphasis on development of aggregated understanding incorporating substrate features in addition to ..
  11. pmc The putative endoglucanase PcGH61D from Phanerochaete chrysosporium is a metal-dependent oxidative enzyme that cleaves cellulose
    Bjørge Westereng
    Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, As, Norway
    PLoS ONE 6:e27807. 2011
    ..gene product of an open reading frame in the genome of Phanerochaete chrysosporium, is an enzyme that cleaves cellulose using a metal-dependent oxidative mechanism that leads to generation of aldonic acids...
  12. ncbi The multicellular morphotypes of Salmonella typhimurium and Escherichia coli produce cellulose as the second component of the extracellular matrix
    X Zogaj
    Division of Cell Biology and Immunology, GBF, D 38124 Braunschweig, Germany
    Mol Microbiol 39:1452-63. 2001
    Production of cellulose has been thought to be restricted to a few bacterial species such as the model organism Acetobacter xylinus...
  13. pmc Systems analysis of plant cell wall degradation by the model filamentous fungus Neurospora crassa
    Chaoguang Tian
    Department of Plant and Microbial Biology, California Institute for Quantitative Biosciences QB3 Chemistry Mass Spectrometry Facility, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:22157-62. 2009
    ..deletion strain set and whole genome microarrays, we undertook a system-wide analysis of plant cell wall and cellulose degradation. We identified approximately 770 genes that showed expression differences when N...
  14. doi Overexpression of two cambium-abundant Chinese fir (Cunninghamia lanceolata) α-expansin genes ClEXPA1 and ClEXPA2 affect growth and development in transgenic tobacco and increase the amount of cellulose in stem cell walls
    Guifeng Wang
    Key Laboratory of Forest Genetics and Biotechnology, Ministry of Education of China, at Nanjing Forestry University, Nanjing, Jiangsu Province, China
    Plant Biotechnol J 9:486-502. 2011
    ..Isolated cell walls of ClEXPA1 and ClEXPA2 overexpressors contained 30%-50% higher cellulose contents than the wild type, accompanied by a thickening of the cell walls in the xylem region...
  15. pmc Structure of cellulose microfibrils in primary cell walls from collenchyma
    Lynne H Thomas
    Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    Plant Physiol 161:465-76. 2013
    In the primary walls of growing plant cells, the glucose polymer cellulose is assembled into long microfibrils a few nanometers in diameter...
  16. pmc High ethanol titers from cellulose by using metabolically engineered thermophilic, anaerobic microbes
    D Aaron Argyros
    Mascoma Corporation, 67 Etna Road, Suite 300, Lebanon, NH 03766, USA
    Appl Environ Microbiol 77:8288-94. 2011
    ..2-fold increase in ethanol yield over the wild-type strain. Ethanol production from cellulose was investigated with an engineered coculture of organic acid-deficient engineered strains of both C...
  17. pmc Organization of cellulose synthase complexes involved in primary cell wall synthesis in Arabidopsis thaliana
    Thierry Desprez
    Laboratoire de Biologie Cellulaire, Unité de Recherche 501, Institut Jean Pierre Bourgin Institut national de la recherche agronomique, Route de St Cyr, 78026 Versailles Cedex, France
    Proc Natl Acad Sci U S A 104:15572-7. 2007
    In all land plants, cellulose is synthesized from hexameric plasma membrane complexes...
  18. pmc The complete genome sequence of Fibrobacter succinogenes S85 reveals a cellulolytic and metabolic specialist
    Garret Suen
    DOE Great Lakes Bioenergy Research Center, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 6:e18814. 2011
    ..which is also one of only two cultivated species in its phylum, is an efficient and prolific degrader of cellulose. Specifically, it has a particularly high activity against crystalline cellulose that requires close physical ..
  19. ncbi Molecular analysis of cellulose biosynthesis in Arabidopsis
    T Arioli
    Cooperative Research Centre for Plant Science, Australian National University, Post Office Box 475, Canberra, ACT 2601, Australia
    Science 279:717-20. 1998
    b>Cellulose, an abundant, crystalline polysaccharide, is central to plant morphogenesis and to many industries...
  20. pmc Crystallographic snapshot of cellulose synthesis and membrane translocation
    Jacob L W Morgan
    Center for Membrane Biology, Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 493:181-6. 2013
    b>Cellulose, the most abundant biological macromolecule, is an extracellular, linear polymer of glucose molecules. It represents an essential component of plant cell walls but is also found in algae and bacteria...
  21. pmc Genomics of aerobic cellulose utilization systems in actinobacteria
    Iain Anderson
    U S Department of Energy Joint Genome Institute, Walnut Creek, California, USA
    PLoS ONE 7:e39331. 2012
    b>Cellulose degrading enzymes have important functions in the biotechnology industry, including the production of biofuels from lignocellulosic biomass...
  22. pmc Oxidoreductive cellulose depolymerization by the enzymes cellobiose dehydrogenase and glycoside hydrolase 61
    James A Langston
    Novozymes, Inc, 1445 Drew Avenue, Davis, California 95618, USA
    Appl Environ Microbiol 77:7007-15. 2011
    ..Cellobiose dehydrogenase (CDH) is a secreted flavocytochrome produced by many cellulose-degrading fungi with no well-understood biological function...
  23. pmc Genetic evidence for three unique components in primary cell-wall cellulose synthase complexes in Arabidopsis
    Staffan Persson
    Department of Plant Biology, Carnegie Institution, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:15566-71. 2007
    In higher plants, cellulose is synthesized at the plasma membrane by the cellulose synthase (CESA) complex. The catalytic core of the complex is believed to be composed of three types of CESA subunits...
  24. doi Oxidative cleavage of cellulose by fungal copper-dependent polysaccharide monooxygenases
    William T Beeson
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Am Chem Soc 134:890-2. 2012
    ..were found to generate oxidized cellodextrins modified at the reducing or nonreducing ends upon incubation with cellulose and cellobiose dehydrogenase. Here we show that the nonreducing end product formed by an N...
  25. ncbi Consolidated bioprocessing of cellulosic biomass: an update
    Lee R Lynd
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Curr Opin Biotechnol 16:577-83. 2005
    ..the focus of most research efforts to date, consolidated bioprocessing (CBP)--featuring cellulase production, cellulose hydrolysis and fermentation in one step--is an alternative approach with outstanding potential...
  26. ncbi Fuel ethanol production from lignocellulose: a challenge for metabolic engineering and process integration
    J Zaldivar
    Center for Process Biotechnology, Department of Biotechnology, Technical University of Denmark, Lyngby
    Appl Microbiol Biotechnol 56:17-34. 2001
    ....
  27. ncbi Effects of cellulose crystallinity, hemicellulose, and lignin on the enzymatic hydrolysis of Miscanthus sinensis to monosaccharides
    Makoto Yoshida
    Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183 8509, Japan
    Biosci Biotechnol Biochem 72:805-10. 2008
    The effects of cellulose crystallinity, hemicellulose, and lignin on the enzymatic hydrolysis of Miscanthus sinensis to monosaccharides were investigated...
  28. pmc Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission
    Richard A Cone
    Mucosal Protection Laboratory, Dept of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Infect Dis 6:90. 2006
    ....
  29. pmc Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety
    Pedro M M Mesquita
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 200:599-608. 2009
    ..The lack of biomarkers that are predictive of safety is a critical gap in the development of microbicides. The present experiments were designed to evaluate the predictive value of in vitro models of microbicide safety...
  30. pmc SND1, a NAC domain transcription factor, is a key regulator of secondary wall synthesis in fibers of Arabidopsis
    Ruiqin Zhong
    Department of Plant Biology, University of Georgia, Athens, Georgia 30602, USA
    Plant Cell 18:3158-70. 2006
    ..Together, our results reveal that SND1 is a key transcriptional activator involved in secondary wall biosynthesis in fibers...
  31. pmc Interactions among three distinct CesA proteins essential for cellulose synthesis
    Neil G Taylor
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 100:1450-5. 2003
    In a screen to identify novel cellulose deficient mutants, three lines were shown to be allelic and define a novel complementation group, irregular xylem5 (irx5)...
  32. pmc Brassinosteroids can regulate cellulose biosynthesis by controlling the expression of CESA genes in Arabidopsis
    Liqiong Xie
    School of Life Science and Technology, Xian Jiaotong University, Xi an 710049, Shanxi Province, People s Republic of China
    J Exp Bot 62:4495-506. 2011
    ..b>Cellulose is a biopolymer which has a major contribution to cell wall formation during cell expansion and elongation...
  33. pmc Sucrose synthase activity in the sus1/sus2/sus3/sus4 Arabidopsis mutant is sufficient to support normal cellulose and starch production
    Edurne Baroja-Fernandez
    Instituto de Agrobiotecnologia, Universidad Pública de Navarra Consejo Superior de Investigaciones Científicas Gobierno de Navarra, 31192 Mutiloabeti, Nafarroa, Spain
    Proc Natl Acad Sci U S A 109:321-6. 2012
    ..The involvement of SUS in the synthesis of UDP-glucose and ADP-glucose linked to Arabidopsis cellulose and starch biosynthesis, respectively, has been questioned by Barratt et al...
  34. doi How biotech can transform biofuels
    Lee R Lynd
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    Nat Biotechnol 26:169-72. 2008
    ..For cellulosic ethanol to become a reality, biotechnological solutions should focus on optimizing the conversion of biomass to sugars...
  35. pmc Characterization of the two Neurospora crassa cellobiose dehydrogenases and their connection to oxidative cellulose degradation
    Christoph Sygmund
    Food Biotechnology Laboratory, Department of Food Sciences and Technology, BOKU, University of Natural Resources and Life Sciences, Vienna, Austria
    Appl Environ Microbiol 78:6161-71. 2012
    ..So far, only CDH IIA, which is induced during growth on cellulose and features a C-terminal carbohydrate binding module (CBM), was detected in the secretome of N...
  36. pmc Coordinated cyclic-di-GMP repression of Salmonella motility through YcgR and cellulose
    Violeta Zorraquino
    Laboratory of Microbial Biofilms, Instituto de Agrobiotecnologia, Idab, Universidad Pública de Navarra CSIC Gobierno de Navarra, Pamplona, Navarra, Spain
    J Bacteriol 195:417-28. 2013
    ..BcsA, upon c-di-GMP binding, synthesizes cellulose, the main exopolysaccharide of the biofilm matrix...
  37. pmc Cellulose microfibril crystallinity is reduced by mutating C-terminal transmembrane region residues CESA1A903V and CESA3T942I of cellulose synthase
    Darby M Harris
    Department of Horticulture, University of Kentucky, Lexington, KY 40546, USA
    Proc Natl Acad Sci U S A 109:4098-103. 2012
    The mechanisms underlying the biosynthesis of cellulose in plants are complex and still poorly understood...
  38. doi Quantitative proteomic approach for cellulose degradation by Neurospora crassa
    Christopher M Phillips
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, United States
    J Proteome Res 10:4177-85. 2011
    ..proteomics approach to characterizing the secretome of Neurospora crassa during growth on microcrystalline cellulose. Thirteen proteins were quantified in the N...
  39. doi Restructuring the crystalline cellulose hydrogen bond network enhances its depolymerization rate
    Shishir P S Chundawat
    Biomass Conversion Research Laboratory, Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824, USA
    J Am Chem Soc 133:11163-74. 2011
    Conversion of lignocellulose to biofuels is partly inefficient due to the deleterious impact of cellulose crystallinity on enzymatic saccharification...
  40. ncbi Swollenin, a Trichoderma reesei protein with sequence similarity to the plant expansins, exhibits disruption activity on cellulosic materials
    Markku Saloheimo
    VTT Biotechnology, PO Box 1500, 02044 VTT, Finland
    Eur J Biochem 269:4202-11. 2002
    ..The protein named swollenin has an N-terminal fungal type cellulose binding domain connected by a linker region to the expansin-like domain...
  41. ncbi Biofilm formation and cellulose expression among diverse environmental Pseudomonas isolates
    Susanne Ude
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
    Environ Microbiol 8:1997-2011. 2006
    ..Calcofluor epifluorescent microscopy identified cellulose as the matrix component in biofilms produced by Pseudomonas asplenii, Pseudomonas corrugata, Pseudomonas ..
  42. doi Microbial diversity of cellulose hydrolysis
    David B Wilson
    Department of Molecular Biology and Genetics, 458 Biotechnology Building, Cornell University, Ithaca, NY 14853, United States
    Curr Opin Microbiol 14:259-63. 2011
    Enzymatic hydrolysis of cellulose by microorganisms is a key step in the global carbon cycle...
  43. doi Cortical microtubules optimize cell-wall crystallinity to drive unidirectional growth in Arabidopsis
    Miki Fujita
    Department of Botany, University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia, V6T 1Z4, Canada
    Plant J 66:915-28. 2011
    The shape of plants depends on cellulose, a biopolymer that self-assembles into crystalline, inextensible microfibrils (CMFs) upon synthesis at the plasma membrane by multi-enzyme cellulose synthase complexes (CSCs)...
  44. pmc Metabolic engineering of Clostridium cellulolyticum for production of isobutanol from cellulose
    Wendy Higashide
    Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, 5531 Boelter Hall, 420 Westwood Plaza, Los Angeles, CA 90095, USA
    Appl Environ Microbiol 77:2727-33. 2011
    Producing biofuels directly from cellulose, known as consolidated bioprocessing, is believed to reduce costs substantially compared to a process in which cellulose degradation and fermentation to fuel are accomplished in separate steps...
  45. pmc Identification of a cellulose synthase-associated protein required for cellulose biosynthesis
    Ying Gu
    Energy Biosciences Institute, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 107:12866-71. 2010
    b>Cellulose synthase-interactive protein 1 (CSI1) was identified in a two-hybrid screen for proteins that interact with cellulose synthase (CESA) isoforms involved in primary plant cell wall synthesis...
  46. doi Cellulose synthases and synthesis in Arabidopsis
    Anne Endler
    Max Planck Institute for Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam, Germany
    Mol Plant 4:199-211. 2011
    ..Among the wall polysaccharides, cellulose, a hydrogen-bonded β-1,4-linked glucan microfibril, is the main load-bearing wall component and a key precursor ..
  47. pmc Sucrose synthase affects carbon partitioning to increase cellulose production and altered cell wall ultrastructure
    Heather D Coleman
    Department of Wood Science, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Proc Natl Acad Sci U S A 106:13118-23. 2009
    ..This activity manifested in altered secondary cell wall cellulose content per dry weight in all lines, with increases of 2% to 6% over control levels, without influencing plant ..
  48. doi Visualization of biomass solubilization and cellulose regeneration during ionic liquid pretreatment of switchgrass
    Seema Singh
    Joint BioEnergy Institute, Deconstruction Division, Emeryville, California, USA
    Biotechnol Bioeng 104:68-75. 2009
    Auto-fluorescent mapping of plant cell walls was used to visualize cellulose and lignin in pristine switchgrass (Panicum virgatum) stems to determine the mechanisms of biomass dissolution during ionic liquid pretreatment...
  49. doi Degradation of cellulose by basidiomycetous fungi
    Petr Baldrian
    Laboratory of Biochemistry of Wood rotting Fungi, Institute of Microbiology of the ASCR v v i, Videnska 1083, Prague 4, Czech Republic
    FEMS Microbiol Rev 32:501-21. 2008
    b>Cellulose is the main polymeric component of the plant cell wall, the most abundant polysaccharide on Earth, and an important renewable resource...
  50. pmc TRICHOME BIREFRINGENCE and its homolog AT5G01360 encode plant-specific DUF231 proteins required for cellulose biosynthesis in Arabidopsis
    Volker Bischoff
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam, Germany
    Plant Physiol 153:590-602. 2010
    The Arabidopsis (Arabidopsis thaliana) trichome birefringence (tbr) mutant has severely reduced crystalline cellulose in trichomes, but the molecular nature of TBR was unknown...
  51. pmc High speed atomic force microscopy visualizes processive movement of Trichoderma reesei cellobiohydrolase I on crystalline cellulose
    Kiyohiko Igarashi
    Department of Biomaterials Sciences, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113 8657, Japan
    J Biol Chem 284:36186-90. 2009
    Fungal cellobiohydrolases act at liquid-solid interfaces. They have the ability to hydrolyze cellulose chains of a crystalline substrate because of their two-domain structure, i.e...
  52. ncbi BSA treatment to enhance enzymatic hydrolysis of cellulose in lignin containing substrates
    Bin Yang
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    Biotechnol Bioeng 94:611-7. 2006
    Cellulase and bovine serum albumin (BSA) were added to Avicel cellulose and solids containing 56% cellulose and 28% lignin from dilute sulfuric acid pretreatment of corn stover...
  53. ncbi Sitosterol-beta-glucoside as primer for cellulose synthesis in plants
    Liangcai Peng
    Section of Plant Biology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Science 295:147-50. 2002
    b>Cellulose synthesis in plants requires beta-1,4-glucan chain initiation, elongation, and termination. The process of chain elongation is likely to be distinct from the process of chain initiation...
  54. pmc Two SusD-like proteins encoded within a polysaccharide utilization locus of an uncultured ruminant Bacteroidetes phylotype bind strongly to cellulose
    A K Mackenzie
    Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, As, Norway
    Appl Environ Microbiol 78:5935-7. 2012
    ..This shows associations between uncultured Bacteroidetes-affiliated lineages and cellulose in the rumen and thus presents new PUL-derived targets to pursue regarding plant biomass degradation.
  55. pmc Polysaccharides cellulose, poly-beta-1,6-n-acetyl-D-glucosamine, and colanic acid are required for optimal binding of Escherichia coli O157:H7 strains to alfalfa sprouts and K-12 strains to plastic but not for binding to epithelial cells
    Ann G Matthysse
    Department of Biology, Coker Hall, University of North Carolina, Chapel Hill, NC 27599 3280, USA
    Appl Environ Microbiol 74:2384-90. 2008
    ..An LPS mutant had no effect on the binding of the pathogenic strain. Cellulose synthase mutants showed a significant reduction in binding; colanic acid mutants were more severely reduced, and ..
  56. doi Renewable and superior thermal-resistant cellulose-based composite nonwoven as lithium-ion battery separator
    Jianjun Zhang
    Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, P R China
    ACS Appl Mater Interfaces 5:128-34. 2013
    A renewable and superior thermal-resistant cellulose-based composite nonwoven was explored as lithium-ion battery separator via an electrospinning technique followed by a dip-coating process...
  57. pmc Differential involvement of β-glucosidases from Hypocrea jecorina in rapid induction of cellulase genes by cellulose and cellobiose
    Qingxin Zhou
    State Key Laboratory of Microbial Technology, School of Life Science, Shandong University, Jinan, Shandong, People s Republic of China
    Eukaryot Cell 11:1371-81. 2012
    Appropriate perception of cellulose outside the cell by transforming it into an intracellular signal ensures the rapid production of cellulases by cellulolytic Hypocrea jecorina...
  58. pmc Collapsed xylem phenotype of Arabidopsis identifies mutants deficient in cellulose deposition in the secondary cell wall
    S R Turner
    University of Manchester, School of Biological Science, United Kingdom
    Plant Cell 9:689-701. 1997
    ..The xylem cell defect was associated with an up to eightfold reduction in the total amount of cellulose in mature inflorescence stems...
  59. ncbi Biodegradation and biological treatments of cellulose, hemicellulose and lignin: an overview
    J Perez
    Departamento de Microbiologia, Facultad de Ciencias, Universidad de Granada, Spain
    Int Microbiol 5:53-63. 2002
    In nature, cellulose, lignocellulose and lignin are major sources of plant biomass; therefore, their recycling is indispensable for the carbon cycle...
  60. doi Transition of cellulose crystalline structure and surface morphology of biomass as a function of ionic liquid pretreatment and its relation to enzymatic hydrolysis
    Gang Cheng
    Joint BioEnergy Institute, Emeryville, California, USA
    Biomacromolecules 12:933-41. 2011
    b>Cellulose is inherently resistant to breakdown, and the native crystalline structure (cellulose I) of cellulose is considered to be one of the major factors limiting its potential in terms of cost-competitive lignocellulosic biofuel ..
  61. ncbi A receptor-like kinase mediates the response of Arabidopsis cells to the inhibition of cellulose synthesis
    Kian Hematy
    Laboratoire de Biologie Cellulaire, UR501, Institut Jean Pierre Bourgin, Institut National de la Recherche Agronomique Centre de Versailles, Route de St Cyr, 78026 Versailles, France
    Curr Biol 17:922-31. 2007
    ..Plant cells, like yeast, react to cell-wall perturbations as shown by changes in gene expression, accumulation of ectopic lignin, and growth arrest caused by the inhibition of cellulose synthesis.
  62. doi Disruption of cellulose synthesis by 2,6-dichlorobenzonitrile affects the structure of the cytoskeleton and cell wall construction in Arabidopsis
    L Peng
    School of Life Science, Ningxia University, Yinchuan, China
    Plant Biol (Stuttg) 15:405-14. 2013
    b>Cellulose is the major component of plant cell walls and is an important source of industrial raw material...
  63. pmc Differential regulation of cellulose orientation at the inner and outer face of epidermal cells in the Arabidopsis hypocotyl
    Elizabeth Faris Crowell
    Institut Jean Pierre Bourgin, Unité Mixte de Recherche 1318, INRA AgroParisTech, Institut National de la Recherche Agronomique Centre de Versailles Grignon, 78000 Versailles, France
    Plant Cell 23:2592-605. 2011
    It is generally believed that cell elongation is regulated by cortical microtubules, which guide the movement of cellulose synthase complexes as they secrete cellulose microfibrils into the periplasmic space...
  64. pmc Identification of the CRE-1 cellulolytic regulon in Neurospora crassa
    Jianping Sun
    Department of Plant and Microbial Biology, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e25654. 2011
    ..In Neurospora crassa, deletion of cre-1 results in increased secretion of amylase and β-galactosidase...
  65. doi Association genetics of traits controlling lignin and cellulose biosynthesis in black cottonwood (Populus trichocarpa, Salicaceae) secondary xylem
    Jill L Wegrzyn
    Department of Plant Sciences, University of California at Davis, Davis, CA 95616, USA
    New Phytol 188:515-32. 2010
    ....
  66. doi Cellodextrin transport in yeast for improved biofuel production
    Jonathan M Galazka
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA
    Science 330:84-6. 2010
    ..fungus Neurospora crassa relies on a high-affinity cellodextrin transport system for rapid growth on cellulose. Reconstitution of the N...
  67. pmc Diversity of glycosyl hydrolases from cellulose-depleting communities enriched from casts of two earthworm species
    Ana Beloqui
    CSIC, Institute of Catalysis, 28049 Madrid, Spain
    Appl Environ Microbiol 76:5934-46. 2010
    ..we retrieved carbohydrate-modifying enzymes through the activity screening of metagenomic fosmid libraries from cellulose-depleting microbial communities established with the fresh casts of two earthworm species, Aporrectodea ..
  68. pmc Identification of a Cis-acting regulatory polymorphism in a Eucalypt COBRA-like gene affecting cellulose content
    Bala R Thumma
    CSIRO Sustainable Ecosystems, Hobart, Tasmania 7001, Australia
    Genetics 183:1153-64. 2009
    ..in a Eucalyptus nitens COBRA-like gene (EniCOBL4A), whose Arabidopsis homolog has been implicated in cellulose deposition...
  69. pmc Carbohydrate-binding modules promote the enzymatic deconstruction of intact plant cell walls by targeting and proximity effects
    Cecile Herve
    Faculty of Biological Sciences, Centre for Plant Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    Proc Natl Acad Sci U S A 107:15293-8. 2010
    ..The capacity of a pectate lyase to degrade pectic homogalacturonan in primary cell walls was potentiated by cellulose-directed CBMs but not by xylan-directed CBMs...
  70. doi Xylooligomers are strong inhibitors of cellulose hydrolysis by enzymes
    Qing Qing
    Center for Environmental Research and Technology and, Chemical and Environmental Engineering Department, Bourns College of Engineering, University of California, Riverside, 1084 Columbia Avenue, Riverside, CA 92507, United States
    Bioresour Technol 101:9624-30. 2010
    ..A comparison among glucose sugars and xylose sugars also showed that xylooligomers were more powerful inhibitors than well-established glucose and cellobiose...
  71. ncbi Cellulase digestibility of pretreated biomass is limited by cellulose accessibility
    Tina Jeoh
    Chemical and Biosciences Center, National Renewable Energy Laboratory, 1617 Cole Blvd, Golden, Colorado 80401, USA
    Biotechnol Bioeng 98:112-22. 2007
    ..In this study, we present a direct method for measuring the key factors governing cellulose digestibility in a biomass sample by directly probing cellulase binding and activity using a purified ..
  72. pmc Chitinase-like1/pom-pom1 and its homolog CTL2 are glucan-interacting proteins important for cellulose biosynthesis in Arabidopsis
    Clara Sánchez-Rodríguez
    Max Planck Institut fur Molekulare Pflanzenphysiologie, 14476 Potsdam Golm, Germany
    Plant Cell 24:589-607. 2012
    Plant cells are encased by a cellulose-containing wall that is essential for plant morphogenesis...
  73. doi Cobtorin target analysis reveals that pectin functions in the deposition of cellulose microfibrils in parallel with cortical microtubules
    Arata Yoneda
    Biomass Engineering Program, RIKEN, 1 7 22, Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Plant J 64:657-67. 2010
    b>Cellulose and pectin are major components of primary cell walls in plants, and it is believed that their mechanical properties are important for cell morphogenesis...
  74. pmc Enhancement of HIV infection by cellulose sulfate
    Wang Tao
    Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    AIDS Res Hum Retroviruses 24:925-9. 2008
    b>Cellulose sulfate, a polyanionic compound derived from cotton, has been proposed as a topical microbicide to reduce the sexual transmission of HIV...
  75. pmc Cellodextrin and laminaribiose ABC transporters in Clostridium thermocellum
    Yakir Nataf
    Department of Biotechnology and Food Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel
    J Bacteriol 191:203-9. 2009
    ..also produce ethanol, it is considered an attractive candidate for a consolidated fermentation process in which cellulose hydrolysis and ethanol fermentation occur in a single process...
  76. doi Cellobiose dehydrogenase and a copper-dependent polysaccharide monooxygenase potentiate cellulose degradation by Neurospora crassa
    Christopher M Phillips
    Department of Molecular and Cell Biology, Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA
    ACS Chem Biol 6:1399-406. 2011
    ..and biochemical techniques, we report that filamentous fungi use oxidative enzymes to cleave glycosidic bonds in cellulose. Deletion of cdh-1, the gene encoding the major cellobiose dehydrogenase of Neurospora crassa, reduced cellulase ..
  77. doi Sucrose synthase is an integral component of the cellulose synthesis machinery
    Satoshi Fujii
    Department of Biological Sciences, Graduate School of Science, Osaka University, Osaka, 560 0043 Japan f
    Plant Cell Physiol 51:294-301. 2010
    b>Cellulose synthesis in plants is believed to be carried out by the plasma membrane-associated rosette structure which can be observed by electron microscopy...
  78. pmc Three distinct rice cellulose synthase catalytic subunit genes required for cellulose synthesis in the secondary wall
    Katsuyuki Tanaka
    Institute of the Society for Techno Innovation of Agriculture, Forestry and Fisheries, Tsukuba, Ibaraki 305 0854, Japan
    Plant Physiol 133:73-83. 2003
    ..brittle mutations of rice, induced by the insertion of the endogenous retrotransposon Tos17, correspond to CesA (cellulose synthase catalytic subunit) genes, OsCesA4, OsCesA7 and OsCesA9...
  79. pmc Microbial cellulose utilization: fundamentals and biotechnology
    Lee R Lynd
    Chemical and Biochemical Engineering, Thayer School of Engineering and Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Microbiol Mol Biol Rev 66:506-77, table of contents. 2002
    Fundamental features of microbial cellulose utilization are examined at successively higher levels of aggregation encompassing the structure and composition of cellulosic biomass, taxonomic diversity, cellulase enzyme systems, molecular ..
  80. doi Metagenomic discovery of biomass-degrading genes and genomes from cow rumen
    Matthias Hess
    Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USA
    Science 331:463-7. 2011
    ..These data sets provide a substantially expanded catalog of genes and genomes participating in the deconstruction of cellulosic biomass...
  81. ncbi Dissolution of cellulose [correction of cellose] with ionic liquids
    Richard P Swatloski
    Center for Green Manufacturing and Department of Chemistry, The University of Alabama, Tuscaloosa, Alabama 35487, USA
    J Am Chem Soc 124:4974-5. 2002
    We report here initial results that demonstrate that cellulose can be dissolved without activation or pretreatment in, and regenerated from, 1-butyl-3-methylimidazolium chloride and other hydrophilic ionic liquids...
  82. pmc Transcriptional analysis of the cip-cel gene cluster from Clostridium cellulolyticum
    Hédia Maamar
    Laboratoire de Bioenergetique et Ingenierie des Proteines, UPR 9036 CNRS, 13402 Marseille Cedex 20, France
    J Bacteriol 188:2614-24. 2006
    ..Two large transcripts were detected in cellulose-grown cells by Northern hybridization: a 14-kb messenger which carries the cipC-cel48F-cel8C-cel9G-cel9E coding ..
  83. pmc A kinesin-like protein is essential for oriented deposition of cellulose microfibrils and cell wall strength
    Ruiqin Zhong
    Department of Plant Biology, University of Georgia, Athens, Georgia 30602, USA
    Plant Cell 14:3101-17. 2002
    Cortical microtubules have long been hypothesized to regulate the oriented deposition of cellulose microfibrils...
  84. ncbi Carbon partitioning to cellulose synthesis
    C H Haigler
    Department of Biological Sciences, Texas Tech University, Lubbock 79409 3131, USA
    Plant Mol Biol 47:29-51. 2001
    This article discusses the importance and implications of regulating carbon partitioning to cellulose synthesis, the characteristics of cells that serve as major sinks for cellulose deposition, and enzymes that participate in the ..
  85. pmc Real-time imaging of cellulose reorientation during cell wall expansion in Arabidopsis roots
    Charles T Anderson
    Energy Biosciences Institute, University of California, Berkeley, California 94720, USA
    Plant Physiol 152:787-96. 2010
    b>Cellulose forms the major load-bearing network of the plant cell wall, which simultaneously protects the cell and directs its growth...
  86. ncbi Characterization of the rdar morphotype, a multicellular behaviour in Enterobacteriaceae
    U Romling
    Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, 17177 Stockholm, Sweden
    Cell Mol Life Sci 62:1234-46. 2005
    ..enterica and Escherichia coli is characterized by the expression of the adhesive extracellular matrix components cellulose and curli fimbriae...
  87. ncbi Genetic analysis of Salmonella enteritidis biofilm formation: critical role of cellulose
    Cristina Solano
    Instituto de Agrobiotecnología y Recursos Naturales and Departamento de Producción Agraria, Universidad Pública de Navarra Consejo Superior de Investigaciones Científicas, 31006 Pamplona, Spain
    Mol Microbiol 43:793-808. 2002
    ..of bcsC and bcsE genes and complementation experiments demonstrated that both operons are responsible for cellulose biosynthesis in both S. enteritidis and S. typhimurium...
  88. doi KORRIGAN1 and its aspen homolog PttCel9A1 decrease cellulose crystallinity in Arabidopsis stems
    Junko Takahashi
    Umea Plant Science Centre, Department of Forest Genetics and Plant Physiology, SLU, Umea, Sweden
    Plant Cell Physiol 50:1099-115. 2009
    KORRIGAN1 (KOR1) is a membrane-bound cellulase implicated in cellulose biosynthesis. PttCel9A1 from hybrid aspen (Populus tremula L. x tremuloides Michx...
  89. pmc Global view of the Clostridium thermocellum cellulosome revealed by quantitative proteomic analysis
    Nicholas D Gold
    Department of Biology, Concordia University, Montreal, Quebec, Canada H4B 1R6
    J Bacteriol 189:6787-95. 2007
    ..patterns of subunits within cellulosomes of the cellulolytic bacterium Clostridium thermocellum, grown on either cellulose or cellobiose...
  90. doi Regenerating cellulose from ionic liquids for an accelerated enzymatic hydrolysis
    Hua Zhao
    Chemistry Program, Savannah State University, 3219 College Street, Savannah, GA 31404, USA
    J Biotechnol 139:47-54. 2009
    ..The pretreatment of lignocelluloses is known to be key to the fast enzymatic hydrolysis of cellulose. Recently, certain ionic liquids (ILs) were found capable of dissolving more than 10wt% cellulose...
  91. ncbi Cellulose biosynthesis in plants: from genes to rosettes
    Monika S Doblin
    University of California, Davis, CA 95616, USA
    Plant Cell Physiol 43:1407-20. 2002
    ..gene cloning have identified the CesA genes as encoding the probable catalytic subunits of the plant CelS, the cellulose synthase enzyme complex visualized in the plasma membrane as rosettes...
  92. doi Bacterial populations and environmental factors controlling cellulose degradation in an acidic Sphagnum peat
    Timofey A Pankratov
    S N Winogradsky Institute of Microbiology, Russian Academy of Sciences, Moscow 117312, Russia
    Environ Microbiol 13:1800-14. 2011
    ..The degradation of cellulose, the major component of Sphagnum-derived litter, was monitored in long-term incubation experiments with acidic (..
  93. doi What do we really know about cellulose biosynthesis in higher plants?
    Gea Guerriero
    Division of Glycoscience, School of Biotechnology, Royal Institute of Technology, AlbaNova University Center, Stockholm, Sweden
    J Integr Plant Biol 52:161-75. 2010
    b>Cellulose biosynthesis is one of the most important biochemical processes in plant biology...
  94. ncbi The role of cellulose and O-antigen capsule in the colonization of plants by Salmonella enterica
    Jeri D Barak
    Produce Safety and Microbiology Research Unit, United States Department of Agriculture Agricultural Research Service, Albany, CA 94710, USA
    Mol Plant Microbe Interact 20:1083-91. 2007
    ..Here, we demonstrate that the other surface polymers composing the extracellular matrix, cellulose, and O-antigen capsule also play a role in colonization of plants...
  95. doi Cellulose nanopaper structures of high toughness
    Marielle Henriksson
    Fibre and Polymer Technology, Royal Institute of Technology, KTH, SE 100 44 Stockholm, Sweden
    Biomacromolecules 9:1579-85. 2008
    b>Cellulose nanofibrils offer interesting potential as a native fibrous constituent of mechanical performance exceeding the plant fibers in current use for commercial products...
  96. doi Cellulose biosynthesis and deposition in higher plants
    Neil G Taylor
    Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK
    New Phytol 178:239-52. 2008
    The plant cell wall is central to plant development. Cellulose is a major component of plant cell walls, and is the world's most abundant biopolymer...
  97. doi Nanoporous cellulose as metal nanoparticles support
    Jie Cai
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Biomacromolecules 10:87-94. 2009
    ..Here, transparent nanoporous cellulose gel obtained from aqueous alkali hydroxide-urea solution was examined as supporting medium for noble metal ..
  98. pmc Gene expression regulation by the Curli activator CsgD protein: modulation of cellulose biosynthesis and control of negative determinants for microbial adhesion
    Eva Brombacher
    Swiss Federal Institute of Environmental Technology, Dubendorf, Switzerland
    J Bacteriol 188:2027-37. 2006
    ..Curli production is dependent on the CsgD transcription activator, which also promotes cellulose biosynthesis...
  99. doi NMR study of cellulose and wheat straw degradation by Ruminococcus albus 20
    Maria Matulova
    Institute of Chemistry, Slovak Academy of Sciences, Centre for Glycomics, Bratislava, Slovak Republic
    FEBS J 275:3503-11. 2008
    b>Cellulose and wheat straw degradation by Ruminococcus albus was monitored using NMR spectroscopy...
  100. doi Traffic jams reduce hydrolytic efficiency of cellulase on cellulose surface
    Kiyohiko Igarashi
    Department of Biomaterial Sciences, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Science 333:1279-82. 2011
    ..We report here the real-time visualization of crystalline cellulose degradation by individual cellulase enzymes through use of an advanced version of high-speed atomic force ..
  101. ncbi Role of cellulose fibrils and exopolysaccharides of Rhizobium leguminosarum in attachment to and infection of Vicia sativa root hairs
    M C Laus
    Institute of Biology Leiden, Leiden University, Wassenaarseweg 64, 2333AL Leiden, The Netherlands
    Mol Plant Microbe Interact 18:533-8. 2005
    ..Bacterial cellulose fibrils have been shown to be involved in this attachment process but appeared not to be essential for ..

Research Grants63

  1. Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
    A Robert Neurath; Fiscal Year: 2004
    b>Cellulose acetate phthalate (CAP) has been used as an enteric film coating material or as a matrix binder for tablets and capsules...
  2. Scalable Purification of Silk-Like Proteins from Transgenic Tobacco
    WILLIAM MARCOTTE; Fiscal Year: 2007
    ..To address this problem, we will express spider silk proteins fused to cellulose-binding domains in transgenic tobacco...
  3. Mechanism of cellulose synthesis and transport across biological membranes
    Jochen Zimmer; Fiscal Year: 2013
    ..typically found in bacterial biofilms include [unreadable]-1,6 linked N-acetyl-glucosamine, alginate, and cellulose. By using the bacterial cellulose synthase machinery as a model system, we propose to determine how ..
  4. Polysaccharide Ecocomposite Materials: Recyclable Synthesis and Applications
    Chieu D Tran; Fiscal Year: 2012
    ..synthesis and applications of composite materials based on the two most abundant biorenewable polysaccharides, cellulose (CEL) and chitotan (CS)...
  5. Integrin Targeted Therapy for the Treatment of Ovarian Cancer
    FRANK CALZONE; Fiscal Year: 2013
    ..and anti-angiogenic disintegrin vicrostatin (VCN), a recombinant protein, impregnated in a carboxymethyl cellulose (CMC) and polyethylene oxide (PEO) gel approved for human use in Europe and Australia for prevention of post-..
  6. Safety of Non-Medicated Intravaginal Rings for Microbicide Delivery
    Marla J Keller; Fiscal Year: 2010
    ..Microbicide trial failures with Nonoxynol-9 (N-9) and cellulose sulfate gels revealed that clinical safety outcomes in early Phase trials were not predictive of safety in Phase ..
  7. Development of Age-Appropriate Fast Disintegrating Pediatric Granules and Tablets
    MOJI ADEYEYE; Fiscal Year: 2009
    ..g., saccharin, sucralose, sucrose) and diluents/binder (e.g., microcrystalline cellulose, dicalcium phosphate) will be examined...
  8. Zosteric Acid Integrated Thermo-reversible Gels for Preventing Surgical Adhesions
    Bi min Newby; Fiscal Year: 2012
    ..form, into a thermo-reversible gel made of Pluronic(R) F-127 and Hydroxyl propyl methyl cellulose, which can then be easily applied in both open and laparoscopic surgeries to prevent adhesion development...
  9. Enabling high dose regional chemotherapy while minimizing systemic toxicity
    Shaker A Mousa; Fiscal Year: 2010
    ..This will be accomplished by a) preparing carbon beads with three different coatings (cellulose with heparin, PMMA and PMMA with heparin) to enhance the biocompatibility of the carbon filters during blood ..
  10. Cellulose-Based Strips for Human Taste Evaluation
    Lloyd Hastings; Fiscal Year: 2010
    ..This test is based on the novel utilization of cellulose/pullulan-based "edible film strips" (EFS) as a vehicle for administering taste stimuli to the oral cavity...
  11. Hemorrhage Control During Brain Surgery
    Weiliam Chen; Fiscal Year: 2010
    ..standard for bleeding control during brain surgery has practically not changed for many decades, with oxidized cellulose, gelatin and collagen as the commonly used materials;thrombin is often deployed in conjunction with these ..
  12. Innovative Biofabrication of 3D Nano-Biocomposites for Repair of Osteochondral De
    LAURIE O'ROURKE; Fiscal Year: 2012
    ..The innovation in this proposal is novel biofabrication process for creating 3D Nano- cellulose hydroxyapatite biocomposite (Nano-biocomposite) which functions as a load bearing articular cartilage and its ..
  13. Multifunctional bone putty for craniomaxillofacial bone repair
    AMBALANGODAGE CHAMPA JAYASURIYA; Fiscal Year: 2013
    ..will be synthesized using growth factors encapsulated chitosan microparticles, calcium chloride, and methyl cellulose. Each material selected for bone putty provides bone-specific properties to enhance bone growth...
  14. Development of a new Imaging Platform for Pharmaceutical and Biomedical applicati
    Lynne S Taylor; Fiscal Year: 2012
    ..model polymers will cover a range of polymer types including those used for oral delivery (polyethylene oxide, cellulose based polymers), biodegradable polymers (polylactic acid, polylactic glycolic acid), and non-erodable device ..
  15. Bioresponsive Combination Microbicide Delivery System for HIV and HSV
    PATRICK FRANKLIN contact KISER; Fiscal Year: 2010
    ..the antiviral nucleoside inhibitors Tenofovir (TNFV) and Acyclovir (ACV), and a viral neutralizing agent CAP (cellulose acetate phthalate)...
  16. Bioactive Compounds from the Biodiversity of Vietnam and Laos
    Djaja D Soejarto; Fiscal Year: 2010
    ..marine biodiversity of South China Sea, and UIC-ICBG Phase II legacy plant extracts;(ii) discovery of new cellulose-degrading and biofuel-producing microbial strains;(iii) advancing new knowledge and strengthening conservation ..
  17. Novel Mucosal Models Predictive of Microbicide Safety
    Marla J Keller; Fiscal Year: 2012
    ..The clinical trial failures with nonoxynol-9 and cellulose sulfate highlight the challenges in microbicide research and the need to establish better markers predictive of ..
  18. Mechanisms of polysacchairde synthesis by S. pneumoniae
    JANET L YOTHER; Fiscal Year: 2010
    ..Among the related enzymes in the glycosyltransferase 2 family are the chitin, cellulose, and hyaluronan synthases...
  19. Near-Infrared VCD of Chiral Pharmaceuticals
    Laurence Nafie; Fiscal Year: 2004
    ..The excipients to be studied include dextrose (glucose), sucrose, lactose, cyclodextrins and cellulose. After these studies, we will measure FT-near-IR-VCD of excipient-supported final pharmaceutical products...
  20. HIV Integrase as a Target for Topical MIcrobicide Development
    Mary Klotman; Fiscal Year: 2009
    ..microbicides to block sexual transmission, have been disappointing as both nonoxynol-9 (N-9) and more recently cellulose sulfate (CS) either did not block transmission or actually enhanced transmission...
  21. Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
    Shibo Jiang; Fiscal Year: 2006
    b>Cellulose acetate phthalate (CAP), used in the pharmaceutical industry for enteric film coating of tablets and capsules, is an HIV-1 entry inhibitor blocking the CXCR4/CCR5 coreceptor binding sites on the virus and eliciting "dead-end" ..
  22. S-nitrosothiol analyzer for the clinical diagnosis of cardiovascular disease mark
    Michael R Pisano; Fiscal Year: 2011
    ..A novel catalytic membrane will be prepared by covalently modifying cellulose dialysis membranes with selenocystamine to enhance the sensitivity of the RSNO sensor...
  23. A practical microbicide based on HIV-1 entry inhibitors
    John P Moore; Fiscal Year: 2012
    ..microbicide candidates have been highlighted by recent failed or halted Phase III trials (COL-1492, SAVVY and Cellulose Sulfate);these trials have suggested that development and formulation of effective microbicides may not be as ..
  24. THROMBOPOIETIN: IMMUNOASSAY AND CHARACTERIZATION
    TED MC DONALD; Fiscal Year: 1993
    ..will be extracted from HEK cells and separated from other nucleic acids by affinity chromatography on oligo-dT cellulose columns; 7) mRNA will be injected into frog oocytes and TSF production measured; 8) mice will be exposed to ..
  25. On-Chip Protein Synthesis Based on Directional Droplet-Ejector Array
    Eun Sok Kim; Fiscal Year: 2010
    ..microfluidic components for producing 100 protein probes of amino acids of arbitrarily specified sequence on a cellulose membrane functionalized with appropriate linker/spacer chemistry...
  26. Cervical/Vaginal Mucus and Microbicides
    Thomas Hope; Fiscal Year: 2013
    ..in semen alone and mixed with mucus and/or microbicide vehicles such as carbopol gel and hydroxy ethyl cellulose (HEC)...
  27. Cervical/Vaginal Mucus and Microbicides
    Thomas Hope; Fiscal Year: 2012
    ..in semen alone and mixed with mucus and/or microbicide vehicles such as carbopol gel and hydroxy ethyl cellulose (HEC)...
  28. HIV Microbicides and the Vaginal Microbiome
    Steven Zeichner; Fiscal Year: 2009
    ..microbial flora before and after microbicide application in a CONRAD repeat phase 1 study of nonoxynol-9 (N-9), cellulose sulfate (CS), and placebo using Affymetrix PhyloChip microarrays 2) Examine the portfolio of expressed genes in ..
  29. ANTI-AIDS NUCLEOSIDE CONJUGATES OF ETHER PHOSPHOLIPIDS
    CHUNG HONG; Fiscal Year: 1992
    ..The conjugate will be purified by a DE-52 (AcO-) cellulose ion exchange column chromatography using a linear gradient of 0-0...
  30. CONTROL OF CORPUS LUTEUM FUNCTION
    John Gadsby; Fiscal Year: 1990
    ..APFPI will then be subjected to ion-exchange (DEAE and CM-cellulose) and Sephadex G-100 chromatography and HPLC...
  31. NON-GASTRIN ACID SECRETAGOGUE IN ISLET CELL TUMORS
    William Chey; Fiscal Year: 1990
    ..Initially, a peptide of NGAS activity will be purified from a Sephadex G-25 fraction of "cholecystokinin CM-cellulose side fraction (CCK-CMC-I)" of intestinal extract by reverse-phase high performance liquid chromatography (HPLC) ..
  32. Assessment of vaccine/microbicide combination efficacy in the macaque model
    CECILIA C CHENG MAYER; Fiscal Year: 2010
    ..SA2) Determine whether topical application of a candidate microbicide, e.g. cellulose acetate 1,2-benzenedicarboxylate (CAP), prior to each challenge in the vaccinated macaques confers added ..
  33. STACHYBOTRYS INDUCED HEMORRHAGE IN THE DEVELOPING LUNG
    Dorr Dearborn; Fiscal Year: 2003
    ..with water damaged homes and the toxigenic fungus called Stachybotrys atra which requires water-saturated cellulose to grow...
  34. ASPERGILLUS ELASTASE, A POTENTIAL VIRULENCE FACTOR
    JUDITH RHODES; Fiscal Year: 1990
    ..The active peak, following ion-exchange on carboxymethyl cellulose, gel filtration chromatography, and adsorption (hydroxyapatite) chromatography, is homogeneous on SDS-PAGE (MW ..
  35. Novel accelerated in vitro breeding for phytoremediation
    MIHALY CZAKO; Fiscal Year: 2007
    ..physiological constraints on dehalogenation); (3) add valuable new traits (morphological variations, higher cellulose to lignin ratio) to elite lines from Phase I and (4) to a salt tolerant line; (5) improve mass propagation, ..
  36. HIV Microbicides and the Vaginal Microbiome
    Steven L Zeichner; Fiscal Year: 2012
    ..microbial flora before and after microbicide application in a CONRAD repeat phase 1 study of nonoxynol-9 (N-9), cellulose sulfate (CS), and placebo using Affymetrix PhyloChip microarrays 2) Examine the portfolio of expressed genes in ..
  37. HEMOGLOBIN SYNTHESIS IN SICKLE CELL TRAIT INDIVIDUALS
    JOSEPH SHAEFFER; Fiscal Year: 1980
    ..the relative amounts of 3H-radioactivity as HbS and HbA were determined by electrophoresis on cellulose acetate strips...
  38. STRUCTURAL ANALYSIS OF LIPOPOLYSACCHARIDES AND LIPID A
    Kuni Takayama; Fiscal Year: 1993
    ..coli D31m3 will be purified by a combination of DEAE cellulose column chromatography and/or silica gel thin-layer chromatography...
  39. A Novel Approach to Prevent Periduaral Fibrosis
    James Pachence; Fiscal Year: 2001
    ..Simple bioresorbable barriers made from hyaluronic acid, regenerated cellulose, or collagen films or gels have been shown to have some efficacy in preventing inter-tissue adhesions, but there ..
  40. PROTEOLYSIS IN HUMAN ERYTHROID CELLS
    JOSEPH SHAEFFER; Fiscal Year: 1991
    ..The pool of excess newly synthesized Alpha chains will be isolated by gel filtration chromatography or cellulose acetate electrophoresis, and their catabolism will be measured by the decrease in acid-precipitable 3H-..
  41. Analysis of the role of patellin in cytokinesis
    T Peterman; Fiscal Year: 2005
    ..Because plant cells are surrounded by a rigid cellulose cell wall that renders them incapable of movement, the spatial and temporal patterns of cell division play a ..
  42. CHARACTERIZATION OF RNA POL II TRANSCRIPTION PROTEINS
    Gyanendra Kumar; Fiscal Year: 1991
    ..will be developed by attaching synthetic DNA duplexes (representing individual protein binding domains) to cellulose, either by direct chemical linkage or via a cellulose-biotin-avidin-biotinylated DNA complex...
  43. MORTALITY & MORBIDITY IN HEMODIALYSIS PATIENTS
    John Daugirdas; Fiscal Year: 2001
    ..serum albumin level) in patients randomly assigned to one of four groups: (A) moderate-dose dialysis, low-flux cellulose membrane, (B)high-dose dialysis, low-flux cellulose membrane, (C) moderate-dose dialysis, high- flux synthetic ..
  44. ISOLATION AND ACTION OF ADULT HEPATOCYTE MITOGENS
    Hyam Leffert; Fiscal Year: 1991
    ..to block the Factor Xo Xa conversion)), characterized structurally (subunit M/r (SDS-PAGE); peptide maps (cellulose TLC); primary sequence (deduced from rat liver cDNA sequences cloned and detected with anti-X-MCA in the ..
  45. Control of Initiation of Development in M. xanthus
    Mitchell Singer; Fiscal Year: 2006
    ..It has been estimated that approximately 95 percent of cellulose-decomposing myxobacteria and 55 percent of the proteolytic strains, including some M...
  46. PREVENTION OF POSTSURGICAL ADHESIONS
    James Pachence; Fiscal Year: 2000
    ..Simple bioresorbable barriers made from hyaluronic acid, regenerated cellulose, or collagen have been shown to have some efficacy in preventing inter-tissue adhesions, but there are still a ..
  47. TEAR ASSAY VS CLINICAL DIAGNOSIS IN HEALTH AND DRY EYE
    RODERICK FULLARD; Fiscal Year: 1990
    ..non-stimulated and stimulated tear proteins profiles in normals using established assays, the efficacy of cellulose sponges for non-stimulated tear collection will be compared with micropipettes...
  48. CHARACTERIZATION OF AH RECEPTOR-RADIOLIGAND INTERACTIONS
    Stephen Safe; Fiscal Year: 1991
    ..D1)-receptor complexes; e) the interactions of the receptor protein-radioligand complexes with DNA utilizing DNA-cellulose columns will also be determined; and the effects of radioligand structure on the nuclear uptake and persistence ..
  49. CELLULAR BIOCHEMISTRY--STRUCTURAL VARIANT
    YAGYA SINHA; Fiscal Year: 1990
    ..Isolations will be carried out by electroelution from gels and by HPLC, Sephadex, and DEAE-cellulose chromatography. Radioimmunoassay and immunoblotting assays will be developed by standard procedures...
  50. MORTALITY AND MORBILITY IN HEMODIALYSIS PATIENTS
    Thomas Depner; Fiscal Year: 2001
    ..The -50% increment in dosage will be combined, using a 2 x 2 factorial design, with a comparison of cellulose-derived dialysis membranes and more porous, biocompatible dialysis membranes...
  51. PATHOBIOLOGICAL DETERMINANTS OF ATHEROSCLEROSIS IN YOUTH
    Edward Miller; Fiscal Year: 1992
    ..The resulting peptide fragments will then be chromatographed on CM-cellulose and portions of the column effluent known to contain marker peptides derived from the chains of type I, III, IV ..
  52. DIET,APOPTOSIS AND COLON CARCINOGENESIS
    Joanne Lupton; Fiscal Year: 2004
    ..A secondary goal is to determine how supplementing fish oil-containing diets with pectin compared to cellulose synergistically enhances the protective effect of fish oil...
  53. NEUROSPORA DNA REPAIR
    Alice Schroeder; Fiscal Year: 1980
    ..salt, Mg ions and pH optima and show identical chromatographic behavior on Sepharose-Blue Dextran, DEAE, and DNA-cellulose. Further characterization of these activities will be undertaken...
  54. Cellulose-Based Strips for Human Taste Evaluation
    Lloyd Hastings; Fiscal Year: 2004
    The main goal of this application is to investigate the feasibility of using cellulose-based polymers, i.e., "edible film strips", as a substrate for delivery of taste stimuli to the oral cavity...
  55. SSB PROTEINS AS ORGANIZERS OF DNA PRECURSOR BIOSYNTHESIS
    Christopher Mathews; Fiscal Year: 2001
    ..Affinity chromatography with immobilized proteins and DNA-cellulose, non-denaturing gel electrophoresis, and immunoprecipitation will be used to distinguish those proteins in the ..
  56. BONE GROWTH AND RHBMP2
    Henry Vasconez; Fiscal Year: 2000
    ..and lyophilization implantable matrices are produced by suspending protein-loaded particles in 2% carboxymethyl cellulose (CMC), lyophilizing, and cutting the dried material to size...
  57. PRODUCING LACTOLYZED MILK AND WHEY BY MONOLITHIC SUPPORT
    ABDUL MAZID; Fiscal Year: 1999
    DESCRIPTION: (adapted from applicant's abstract) The goal of this research is to produce a flexible monolithic cellulose support with advantageous characteristics; a version with high activity of immobilized beta-galactosidase will be ..
  58. HIGH PERFORMANCE CENTRIFUGAL ULTRAFILTRATION DEVICES
    William Bowers; Fiscal Year: 2001
    ..A 7 mL prototype device having regenerated cellulose (RC) non-fouling membrane area 4x greater than current 2mL RC devices has been shown to have l00x greater rate ..
  59. CHEMORECEPTION FOR INSOLUBLE SUBSTANCES--STARCH & OIL
    Israel Ramirez; Fiscal Year: 1993
    ..starch and the same fluid without starch, consistently preferred fluids containing starch but did not respond to cellulose. Experiments are proposed to examine the mechanisms by which chemosensory systems may detect insoluble ..
  60. FIBROBLASTIC HETEROGENEITY IN OROFACIAL SCARRING
    Charles Bertolami; Fiscal Year: 1993
    ..Mass cultures will be initiated for each of the tissue types. Using quantitative cellulose acetate electrophoresis and a panel of unique monoclonal antibodies that recognize novel epitopes in GAG chains, ..
  61. MECHANISMS OF GROWTH-PROMOTING ACTION OF TOXIC QUINONES
    Timothy Chan; Fiscal Year: 1993
    ..be used include: Sephacryl S-300 chromatography, immunoprecipitation using antiphosphotyrosine antibody agarose, cellulose acetate electrophoresis, and protein and lipid phosphorylation...
  62. Novel Mucosal Models Predictive of Microbicide Safety
    Betsy Herold; Fiscal Year: 2009
    ..The clinical trial failures with nonoxynol-9 and cellulose sulfate highlight the challenges in microbicide research and the need to establish better markers predictive of ..
  63. Microbicide Effects on Efficacy, Safety, Innate Immunity
    Marla J Keller; Fiscal Year: 2010
    ..Carefully planned pilot clinical evaluation of compounds already in clinical trials (cellulose sulfate, acidform and tenofovir) as well as the proposed formulated SAMMA will focus on the effects of these ..