photosystem i protein complex

Summary

Summary: A large multisubunit protein complex that is found in the THYLAKOID MEMBRANE. It uses light energy derived from LIGHT-HARVESTING PROTEIN COMPLEXES to drive electron transfer reactions that result in either the reduction of NADP to NADPH or the transport of PROTONS across the membrane.

Top Publications

  1. ncbi Characterisation of senescence-induced changes in light harvesting complex II and photosystem I complex of thylakoids of Cucumis sativus cotyledons: age induced association of LHCII with photosystem I
    Jogadhenu Syama Sundara Prakash
    School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110 067, India
    J Plant Physiol 160:175-84. 2003
  2. ncbi Determining the limitations and regulation of photosynthetic energy transduction in leaves
    Neil R Baker
    Department of Biological Sciences, University of Essex, Colchester, CO4 3SQ, Essex, UK
    Plant Cell Environ 30:1107-25. 2007
  3. ncbi The long-term responses of the photosynthetic proton circuit to drought
    Kaori Kohzuma
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Plant Cell Environ 32:209-19. 2009
  4. ncbi Crystal structure of plant photosystem I
    Adam Ben-Shem
    Department of Biochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Nature 426:630-5. 2003
  5. ncbi Proteomic approach to characterize the supramolecular organization of photosystems in higher plants
    Jesco Heinemeyer
    , , , D-30419 Hannover, Germany
    Phytochemistry 65:1683-92. 2004
  6. ncbi Irreversible damage to photosystem I by chilling in the light: cause of the degradation of chlorophyll after returning to normal growth temperature
    Hideki Kudoh
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Bldg. FSB Box 101, Kashiwanoha 5-1-5, Kashiwa-shi, Chiba 277-8562, Japan
    Planta 215:541-8. 2002
  7. ncbi Dynamic flexibility in the light reactions of photosynthesis governed by both electron and proton transfer reactions
    David M Kramer
    Institute of Biological Chemistry, Washington State University, Pullman, WA 99164, USA
    Trends Plant Sci 9:349-57. 2004
  8. ncbi The long-term response to fluctuating light quality is an important and distinct light acclimation mechanism that supports survival of Arabidopsis thaliana under low light conditions
    Raik Wagner
    Junior Research Group, Institute for General Botany and Plant Physiology, Friedrich Schiller University Jena, Dornburger Str 159, 07743 Jena, Germany
    Planta 228:573-87. 2008
  9. ncbi Quantification of cyclic and linear flows in plants
    Pierre Joliot
    Institut de Biologie PhysicoChimique, Centre National de la Recherche Scientifique, Unité Propre de Recherche 1261, 13 rue Pierre et Marie Curie, 75005 Paris, France
    Proc Natl Acad Sci U S A 102:4913-8. 2005
  10. ncbi Photosystem II complex in vivo is a monomer
    Takeshi Takahashi
    Graduate School of Life Science, University of Hyogo, 3 2 1 Kohto, Kamigohri, Ako gun, Hyogo 678 1297, Japan
    J Biol Chem 284:15598-606. 2009

Research Grants

  1. FLAVIN-PROTEIN INTERACTIONS IN FLAVOENZYME CATALYSIS
    Gordon Tollin; Fiscal Year: 1993
  2. STRUCTURE/FUNCTION OF PHOTOSYNTHETIC CYTOCHROME COMPLEX
    WILLIAM CRAMER; Fiscal Year: 1993
  3. Femtosecond nano-crystallography of membrane proteins
    Petra Fromme; Fiscal Year: 2010
  4. DISTANCE MEASUREMENTS IN METALLOPROTEINS
    GARY BRUDVIG; Fiscal Year: 2002
  5. 250/500 GHZ GYROTRON BASED DNP/EPR SPECTROMETER
    RICHARD TEMKIN; Fiscal Year: 2003
  6. SPECTROSCOPIC STUDIES OF LIGHT-DRIVEN ELECTRON TRANSFER
    BRIDGETTE BARRY; Fiscal Year: 2007
  7. PHYTOCHROME REGULATION OF SPECIFIC GENE EXPRESSION
    ELAINE TOBIN; Fiscal Year: 1991
  8. Disassembly and degradation of Photosystem I
    Kevin Redding; Fiscal Year: 2005
  9. Supercritical Fluid Extraction for Membrane Proteomics
    Lloyd Smith; Fiscal Year: 2006
  10. MOLECULAR AND CELLULAR BACTERIAL PATHOGENESIS
    David Briles; Fiscal Year: 2007

Detail Information

Publications262 found, 100 shown here

  1. ncbi Characterisation of senescence-induced changes in light harvesting complex II and photosystem I complex of thylakoids of Cucumis sativus cotyledons: age induced association of LHCII with photosystem I
    Jogadhenu Syama Sundara Prakash
    School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110 067, India
    J Plant Physiol 160:175-84. 2003
    ..The nature of aging induced migration and association of LHCII with PSI and its existence in other senescing systems need to be estimated in the future...
  2. ncbi Determining the limitations and regulation of photosynthetic energy transduction in leaves
    Neil R Baker
    Department of Biological Sciences, University of Essex, Colchester, CO4 3SQ, Essex, UK
    Plant Cell Environ 30:1107-25. 2007
    ..Non-invasive probing of electron fluxes through PSI and PSII, and proton fluxes across the thylakoid membranes can provide insights into the operation of such regulatory processes in vivo...
  3. ncbi The long-term responses of the photosynthetic proton circuit to drought
    Kaori Kohzuma
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Plant Cell Environ 32:209-19. 2009
    ....
  4. ncbi Crystal structure of plant photosystem I
    Adam Ben-Shem
    Department of Biochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Nature 426:630-5. 2003
    ....
  5. ncbi Proteomic approach to characterize the supramolecular organization of photosystems in higher plants
    Jesco Heinemeyer
    , , , D-30419 Hannover, Germany
    Phytochemistry 65:1683-92. 2004
    ..Further application of this experimental approach will allow new insights into the supermolecular organization of photosystems in plants...
  6. ncbi Irreversible damage to photosystem I by chilling in the light: cause of the degradation of chlorophyll after returning to normal growth temperature
    Hideki Kudoh
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Bldg. FSB Box 101, Kashiwanoha 5-1-5, Kashiwa-shi, Chiba 277-8562, Japan
    Planta 215:541-8. 2002
    ..e. irreversibility of the injury and development of visible symptoms at room temperature, can be explained as a consequence of the chilling-induced photoinhibition of PSI...
  7. ncbi Dynamic flexibility in the light reactions of photosynthesis governed by both electron and proton transfer reactions
    David M Kramer
    Institute of Biological Chemistry, Washington State University, Pullman, WA 99164, USA
    Trends Plant Sci 9:349-57. 2004
    ....
  8. ncbi The long-term response to fluctuating light quality is an important and distinct light acclimation mechanism that supports survival of Arabidopsis thaliana under low light conditions
    Raik Wagner
    Junior Research Group, Institute for General Botany and Plant Physiology, Friedrich Schiller University Jena, Dornburger Str 159, 07743 Jena, Germany
    Planta 228:573-87. 2008
    ..Thus, the LTR represents a distinct acclimation response in addition to other already known responses that clearly improves plant physiology under low light conditions resulting in a pronounced positive effect on plant fitness...
  9. ncbi Quantification of cyclic and linear flows in plants
    Pierre Joliot
    Institut de Biologie PhysicoChimique, Centre National de la Recherche Scientifique, Unité Propre de Recherche 1261, 13 rue Pierre et Marie Curie, 75005 Paris, France
    Proc Natl Acad Sci U S A 102:4913-8. 2005
    ..A. (2001) Trends Plant Sci. 6, 349-354]...
  10. ncbi Photosystem II complex in vivo is a monomer
    Takeshi Takahashi
    Graduate School of Life Science, University of Hyogo, 3 2 1 Kohto, Kamigohri, Ako gun, Hyogo 678 1297, Japan
    J Biol Chem 284:15598-606. 2009
    ..Our proposal will lead to a re-evaluation of many crystallographic models of membrane protein complexes in terms of their oligomerization status...
  11. ncbi Plant photosystem I--the most efficient nano-photochemical machine
    Nathan Nelson
    Biochemistry Department, The George S Wise Faculty of Life Sciences, The Daniella Rich Institute for Structural Biology, Tel Aviv University, Tel Aviv 69978, Israel
    J Nanosci Nanotechnol 9:1709-13. 2009
    ..The structure should provide a template for designing artificial systems amenable for utilizable energy production...
  12. ncbi Structure and function of intact photosystem 1 monomers from the cyanobacterium Thermosynechococcus elongatus
    Eithar El-Mohsnawy
    Plant Biochemistry, Ruhr University Bochum, 44780 Bochum, Germany
    Biochemistry 49:4740-51. 2010
    ....
  13. ncbi Light-harvesting complex II protein CP29 binds to photosystem I of Chlamydomonas reinhardtii under State 2 conditions
    Joanna Kargul
    Wolfson Laboratories, Division of Molecular Biosciences, Imperial College London, UK
    FEBS J 272:4797-806. 2005
    ....
  14. ncbi Recombinant Lhca2 and Lhca3 subunits of the photosystem I antenna system
    Simona Castelletti
    Dipartimento Scientifico e Tecnologico, , Strada Le Grazie, 15- 37234 Verona, Italy
    Biochemistry 42:4226-34. 2003
    ..thaliana...
  15. ncbi Three-dimensional structure of cyanobacterial photosystem I at 2.5 A resolution
    P Jordan
    Institut für Chemie Kristallographie, Freie Universitat Berlin, D 14195 Berlin, Takustrasse 6, Germany
    Nature 411:909-17. 2001
    ..The structural information on the proteins and cofactors and their interactions provides a basis for understanding how the high efficiency of photosystem I in light capturing and electron transfer is achieved...
  16. ncbi Structure and functional role of supercomplexes of IsiA and Photosystem I in cyanobacterial photosynthesis
    Roman Kouril
    Department of Biophysical Chemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    FEBS Lett 579:3253-7. 2005
    ..Work on mutants indicates that the PsaF/J and PsaL subunits facilitate the formation of closed rings around Photosystem I monomers but are not obligatory components in the formation of Photosystem I-IsiA supercomplexes...
  17. ncbi Biochemical and structural studies of the large Ycf4-photosystem I assembly complex of the green alga Chlamydomonas reinhardtii
    Shin Ichiro Ozawa
    Graduate School of Natural Science and Technology, Okayama University, Okayama 700 8530, Japan
    Plant Cell 21:2424-42. 2009
    ..A decrease in COP2 to 10% of wild-type levels by RNA interference increased the salt sensitivity of the Ycf4 complex stability but did not affect the accumulation of PSI, suggesting that COP2 is not essential for PSI assembly...
  18. ncbi A genome's-eye view of the light-harvesting polypeptides of Chlamydomonas reinhardtii
    D Elrad
    The Department of Plant Biology, The Carnegie Institution of Washington, 260 Panama Street, Stanford, CA 94305, USA
    Curr Genet 45:61-75. 2004
    ..reinhardtii genome. This is an important first step in designing specific genetic, biochemical, and physiological studies aimed at characterizing the composition, function, and regulation of the light-harvesting complexes...
  19. ncbi Characterization of the cyanobacterial ycf37: mutation decreases the photosystem I content
    A Wilde
    , , Chausseestrasse 117, 10115 Berlin, Germany
    Biochem J 357:211-6. 2001
    ..The observed alterations in the ycf37 mutants and the structural organization of the gene product suggest a functional role in PSI stability or assembly...
  20. ncbi Stoichiometry of LHCI antenna polypeptides and characterization of gap and linker pigments in higher plants Photosystem I
    Matteo Ballottari
    Dipartimento Scientifico e Tecnologico, , Verona, Italy
    Eur J Biochem 271:4659-65. 2004
    ....
  21. ncbi Supramolecular organization of thylakoid membrane proteins in green plants
    Jan P Dekker
    Faculty of Sciences, Division of Physics and Astronomy, Vrije Universiteit, De Boelelaan 1081, 1081 HV Amsterdam, Netherlands
    Biochim Biophys Acta 1706:12-39. 2005
    ....
  22. ncbi Active oxygen produced during selective excitation of photosystem I is damaging not only to photosystem I, but also to photosystem II
    S E Tjus
    Plant Biochemistry Laboratory, Department of Plant Biology, The Royal Veterinary and Agricultural University, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Copenhagen, Denmark
    Plant Physiol 125:2007-15. 2001
    ..Addition of active oxygen scavengers during the far-red photosystem I illumination demonstrated superoxide to be a major cause of damage to photosystem I, whereas photosystem II was damaged mainly by superoxide and hydrogen peroxide...
  23. ncbi Functional organization of a plant Photosystem I: evolution of a highly efficient photochemical machine
    Alexey Amunts
    Biochemistry Department, The George S Wise Faculty of Life Sciences, The Daniella Rich Institute for Structural Biology, Tel Aviv University, Sherman Building, Room 531, Tel Aviv 69978, Israel
    Plant Physiol Biochem 46:228-37. 2008
    ..The present comprehensive structural analysis summarizes our current state of knowledge, providing the first glimpse at the architecture of this highly efficient photochemical machine at the atomic level...
  24. ncbi Protective effect of active oxygen scavengers on protein degradation and photochemical function in photosystem I submembrane fractions during light stress
    Subramanyam Rajagopal
    , , , Canada
    FEBS J 272:892-902. 2005
    ..The specific action of histidine and n-propyl gallate indicates that 1O2 was the main form of reactive oxygen species responsible for strong light-induced damage in PSI submembrane fractions...
  25. ncbi Photoinhibition of Chlamydomonas reinhardtii in State 1 and State 2: damages to the photosynthetic apparatus under linear and cyclic electron flow
    G Finazzi
    Centro di Studio del CNR sulla Biologia Cellulare e Molecolare delle Piante, Via Celoria 26, 20133 Milano, Italy
    J Biol Chem 276:22251-7. 2001
    ..This capacity might represent an important physiological tool in protecting the photosynthetic apparatus from excess of light as well as from other a-biotic stress conditions...
  26. ncbi Short- and long-term operation of the lutein-epoxide cycle in light-harvesting antenna complexes
    Shizue Matsubara
    Phytosphäre Institut Institut für Chemie und Dynamik der Geosphäre 3, Forschungszentrum Julich, 52425 Juelich, Germany
    Plant Physiol 144:926-41. 2007
    ..These results are discussed in the context of photoacclimation and shade adaptation...
  27. ncbi Retrograde plastid redox signals in the expression of nuclear genes for chloroplast proteins of Arabidopsis thaliana
    Vidal Fey
    Department for Plant Physiology, Friedrich-Schiller-University Jena, Dornburger Strasse 159, 07743 Jena, Germany
    J Biol Chem 280:5318-28. 2005
    ..These redox signals appear to act independently and/or above of cytosolic photoreceptor or known chloroplast-to-nucleus communication avenues...
  28. ncbi Lhca5--an LHC-type protein associated with photosystem I
    Ulrika Ganeteg
    Umea Plant Science Centre, Department of Plant Physiology, Umea University, S 901 87 Umea, Sweden
    Plant Mol Biol 54:641-51. 2004
    ..We propose that Lhca5 binds chlorophylls in a similar fashion to the other Lhca proteins and is associated with PSI only in sub-stoichiometric amounts...
  29. ncbi Proteomics of Chlamydomonas reinhardtii light-harvesting proteins
    Einar J Stauber
    , , 07743 Jena, Germany
    Eukaryot Cell 2:978-94. 2003
    ..This proteomic study demonstrates the complexity of the light-harvesting proteins at the protein level in C. reinhardtii and will be an important basis of future functional studies addressing this diversity...
  30. ncbi Plant photosystem I design in the light of evolution
    Alexey Amunts
    Biochemistry Department, George S Wise Faculty of Life Sciences, The Daniella Rich Institute for Structural Biology, Tel Aviv University, Tel Aviv, Israel
    Structure 17:637-50. 2009
    ..In addition, some aspects of PSI structure determination are discussed...
  31. ncbi Control of energy dissipation and photochemical activity in photosystem I by NADP-dependent reversible conformational changes
    Subramanyam Rajagopal
    , , , , Canada G9A 5H7
    Biochemistry 42:11839-45. 2003
    ..This new control mechanism of energy dissipation and photochemical activity by NADP(+)/NADPH is proposed to increase the turnover rate of PSI under conditions when both linear and cyclic electron transport activities must be supported...
  32. ncbi Photoinhibition of photosystem I is accelerated by dimethyldithiocarbamate, an inhibitor of superoxide dismutase, during light-chilling of spinach leaves
    Hong Jin Hwang
    Department of Molecular Biology, Pusan National University, Busan 609 735, South Korea
    J Photochem Photobiol B 73:79-85. 2004
    ..The possible dissociation of LHC I as an early structural change in the PS I complex after DDC-induced photoinhibition of PS I is discussed...
  33. ncbi The Arabidopsis chloroplastic NifU-like protein CnfU, which can act as an iron-sulfur cluster scaffold protein, is required for biogenesis of ferredoxin and photosystem I
    Toshiki Yabe
    Institute for Protein Research, Osaka University, Suita, 565 0871, Japan
    Plant Cell 16:993-1007. 2004
    ..We propose that AtCnfU has an important function as a molecular scaffold for iron-sulfur cluster biosynthesis in chloroplasts and thereby is required for biogenesis of ferredoxin and photosystem I...
  34. ncbi The nature of a chlorophyll ligand in Lhca proteins determines the far red fluorescence emission typical of photosystem I
    Tomas Morosinotto
    Dipartimento Scientifico e Tecnologico, , Strada Le Grazie, 15-37134 Verona, Italy
    J Biol Chem 278:49223-9. 2003
    ..Because the mutation does not affect Chl A5 orientation, we suggest that coordination by Asn of Chl A5 holds it at the correct distance with Chl B5...
  35. ncbi Evolution of photosystem I - from symmetry through pseudo-symmetry to asymmetry
    Adam Ben-Shem
    Department of Biochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    FEBS Lett 564:274-80. 2004
    ....
  36. ncbi A photosystem 1 psaFJ-null mutant of the cyanobacterium Synechocystis PCC 6803 expresses the isiAB operon under iron replete conditions
    Robert Jeanjean
    LCB-CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    FEBS Lett 549:52-6. 2003
    ..Products are the IsiA chlorophyll-binding protein (CP43') and the isiB gene product flavodoxin. Supporting evidence was obtained by similar isiAB induction in wild type cells artificially exposed to oxidative stress...
  37. ncbi Cyclic electron flow around photosystem I is essential for photosynthesis
    Yuri Munekage
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630-0101, Japan
    Nature 429:579-82. 2004
    ..Here we have constructed mutants in Arabidopsis thaliana in which both PSI cyclic pathways are impaired, and present evidence that cyclic flow is essential for efficient photosynthesis...
  38. ncbi PGR5 is involved in cyclic electron flow around photosystem I and is essential for photoprotection in Arabidopsis
    Yuri Munekage
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Japan
    Cell 110:361-71. 2002
    ..Under these conditions, the PGR5 pathway also functions to limit the overreduction of the acceptor side of photosystem I, thus preventing photosystem I photoinhibition...
  39. ncbi The high light-inducible polypeptides stabilize trimeric photosystem I complex under high light conditions in Synechocystis PCC 6803
    Qiang Wang
    Department of Applied Science, University of Arkansas, Little Rock, Arkansas 72204, USA
    Plant Physiol 147:1239-50. 2008
    ..These results suggest that the HLIPs stabilize PSI trimers, interact with Slr1128, and protect cells under HL conditions...
  40. ncbi Structure determination and improved model of plant photosystem I
    Alexey Amunts
    Biochemistry Department, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 285:3478-86. 2010
    ..Using the new crystal structure, we examine the network of contacts among the protein subunits from the structural perspective, which provide the basis for elucidating the functional organization of the complex...
  41. ncbi Three-dimensional reconstruction of a light-harvesting complex I-photosystem I (LHCI-PSI) supercomplex from the green alga Chlamydomonas reinhardtii. Insights into light harvesting for PSI
    Joanna Kargul
    Wolfson Laboratories, Department of Biological Sciences, South Kensington Campus, Imperial College London, London SW7 2AZ, United Kingdom
    J Biol Chem 278:16135-41. 2003
    ..There was no evidence for oligomerization of Chlamydomonas PSI in contrast to the trimerization of PSI in cyanobacteria...
  42. ncbi Self-assembling peptide detergents stabilize isolated photosystem I on a dry surface for an extended time
    Patrick Kiley
    Center for Biomedical Engineering NE47-379, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Biol 3:e230. 2005
    ..These observations suggest that the peptide detergents may effectively stabilize membrane proteins in the solid-state. These designed peptide detergents may facilitate the study of diverse types of membrane proteins...
  43. ncbi Measurement of photochemical quenching of absorbed quanta in photosystem I of intact leaves using simultaneous measurements of absorbance changes at 830 nm and thermal dissipation
    Nikolai G Bukhov
    , , , , Canada
    Planta 216:630-8. 2003
    ..The above illustrates the strong photochemical energy quenching occurring when the reaction centers are in open state (reduced P700)...
  44. ncbi Differential use of two cyclic electron flows around photosystem I for driving CO2-concentration mechanism in C4 photosynthesis
    Atsushi Takabayashi
    Graduate School of Biostudies, Kyoto University, Sakyo, Kyoto 606 8502, Japan
    Proc Natl Acad Sci U S A 102:16898-903. 2005
    ..Our results indicate that CEF via NDH plays a central role in driving the CO(2)-concentrating mechanism in C(4) photosynthesis...
  45. ncbi Characterization of a novel Photosystem I-LHCI supercomplex isolated from Chlamydomonas reinhardtii under anaerobic (State II) conditions
    Rajagopal Subramanyam
    School of Life Sciences and Center for the Study of Early Events in Photosynthesis, P.O. Box, 874501, Arizona State University, Tempe, AZ 85287-4501, USA
    FEBS Lett 580:233-8. 2006
    ..These results indicate that there are large and dynamic changes of the PSI-LHCI supercomplex during the acclimation from aerobic (State I) to anaerobic (State II) conditions in Chlamydomonas...
  46. ncbi Molecular identification of a novel protein that regulates biogenesis of photosystem I, a membrane protein complex
    V V Bartsevich
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    J Biol Chem 272:6382-7. 1997
    ....
  47. ncbi Contrasting behavior of higher plant photosystem I and II antenna systems during acclimation
    Matteo Ballottari
    Dipartimento Scientifico e Tecnologico, Universita di Verona, Strada Le Grazie, 15 37134 Verona, Italy
    J Biol Chem 282:8947-58. 2007
    ....
  48. ncbi Role of thylakoid protein kinases in photosynthetic acclimation
    Jean David Rochaix
    Department of Molecular Biology, University of Geneva, 30, Quai Ernest Ansermet, 1211 Geneva, Switzerland
    FEBS Lett 581:2768-75. 2007
    ..These kinases appear to be involved both in short and long term adaptations to changes in the light environment...
  49. ncbi On the advantages of using green light to study fluorescence yield changes in leaves
    Fabrice Rappaport
    Institut de Biologie Physico Chimique, UMR 7141 CNRS Paris 6, Paris, France
    Biochim Biophys Acta 1767:56-65. 2007
    ..We ascribe this plateau to the time delay needed to reduce the photosystem I electron acceptors...
  50. ncbi Molecular heterogeneity of photosystem I. psaD, psaE, psaF, psaH, and psaL are all present in isoforms in Nicotiana spp
    J Obokata
    Department of Botany, Faculty of Science, Hokkaido University, Sapporo, Japan
    Plant Physiol 102:1259-67. 1993
    ..thaliana, and corn, and two isoforms of psaE products were detected in tomato, A. thaliana, and red bean. These results suggest that the nuclear-encoded subunits of PSI, except for the psaG and psaK products, generally have two isoforms...
  51. ncbi Redox modulation of cyclic electron flow around photosystem I in C3 plants
    Cécile Breyton
    UMR 7099, CNRS Université Paris 7, Institut de Biologie Physico Chimique, Paris, France
    Biochemistry 45:13465-75. 2006
    ..This would be ultimately regulated by the balance between the redox state of PSI acceptors and donors during photosynthesis, in a diffusing system...
  52. ncbi The E subunit of photosystem I is not essential for linear electron flow and photoautotrophic growth in Arabidopsis thaliana
    Anna Ihnatowicz
    Abteilung für Pflanzenzüchtung und Genetik, Max Planck Institut fur Zuchtungsforschung, Carl von Linne Weg 10, 50829 Köln, Germany
    Planta 226:889-95. 2007
    ..The psae1-3 psae2-1 double mutant totally lacked PSI-E but was still able to grow photoautotrophically, implying that PSI-E is not essential for PSI accumulation and thylakoid electron flow...
  53. ncbi The structure of a plant photosystem I supercomplex at 3.4 A resolution
    Alexey Amunts
    Department of Biochemistry, The George S Wise Faculty of Life Sciences, The Daniella Rich Institute for Structural Biology, Tel Aviv University, Tel Aviv, 69978, Israel
    Nature 447:58-63. 2007
    ..This structural information extends the understanding of the most efficient nano-photochemical machine in nature...
  54. ncbi HCF164 receives reducing equivalents from stromal thioredoxin across the thylakoid membrane and mediates reduction of target proteins in the thylakoid lumen
    Ken Motohashi
    The ATP System Project, ERATO, JST, Nagatsuta 5800 3, Midori ku, Yokohama, Japan
    J Biol Chem 281:35039-47. 2006
    ..The data presented here suggest that HCF164 serves as an important transducer of reducing equivalents to proteins in the thylakoid lumen...
  55. ncbi Singlet and triplet state transitions of carotenoids in the antenna complexes of higher-plant photosystem I
    Roberta Croce
    Department of Biophysical Chemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    Biochemistry 46:3846-55. 2007
    ..This suggests that in the Lhca2-Lhca3 heterodimeric complex energy equilibration is not complete at least on a fast time scale...
  56. ncbi Photosystem I is indispensable for photoautotrophic growth, CO2 fixation, and H2 photoproduction in Chlamydomonas reinhardtii
    K Redding
    Departments of Molecular Biology and Plant Biology, University of Geneva, 30 Quai Ernest Ansermet, CH1211 Geneva 4, Switzerland
    J Biol Chem 274:10466-73. 1999
    ..We conclude that the reported instances of CO2 fixation, H2 photoevolution, and photoautotrophic growth of photosystem I-deficient mutants result from the presence of unrecognized photosystem I...
  57. ncbi The evolutionarily conserved tetratrico peptide repeat protein pale yellow green7 is required for photosystem I accumulation in Arabidopsis and copurifies with the complex
    Jana Stöckel
    Institut für Allgemeine Botanik und Pflanzenphysiologie, Friedrich Schiller University, 07747 Jena, Germany
    Plant Physiol 141:870-8. 2006
    ..Whereas the cyanobacterial protein mediates more efficient PSI accumulation, the higher plant protein is absolutely required for complex assembly or maintenance...
  58. ncbi Comparison of the light-harvesting networks of plant and cyanobacterial photosystem I
    Melih K Sener
    Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
    Biophys J 89:1630-42. 2005
    ..The finding suggests that after close packing of chlorophylls was achieved, constraints other than efficiency of the overall excitation transfer process precluded further evolution of pigment ordering...
  59. ncbi The PSI-K subunit of photosystem I is involved in the interaction between light-harvesting complex I and the photosystem I reaction center core
    P E Jensen
    Plant Biochemistry Laboratory, Department of Plant Biology, The Royal Veterinary and Agricultural University, Thorvaldsensvej 40, DK 1871 Frederiksberg C, Denmark
    J Biol Chem 275:24701-8. 2000
    ..The observed effects demonstrate that PSI-K has a role in organizing the peripheral light-harvesting complexes on the core antenna of photosystem I...
  60. ncbi Isolation and characterization of photoautotrophic mutants of Chlamydomonas reinhardtii deficient in state transition
    M M Fleischmann
    Department of Molecular Biology, University of Geneva, 1211 Geneva 4, Switzerland
    J Biol Chem 274:30987-94. 1999
    ..Mutant stt3-4b is partially deficient in state transition but is still able to phosphorylate LHCII. Potential factors affected in these mutant strains and the function of state transition in C. reinhardtii are discussed...
  61. ncbi The structure of photosystem I and evolution of photosynthesis
    Nathan Nelson
    Department of Biochemistry, The George S Wise Faculty of Life Sciences, The Daniella Rich Institute for Structural Biology, Tel Aviv University, Israel
    Bioessays 27:914-22. 2005
    ..The available structural information complements the knowledge gained from genomic and proteomic data to illustrate a more precise scenario for the evolution of life systems on earth...
  62. ncbi A previously found thylakoid membrane protein of 14kDa (TMP14) is a novel subunit of plant photosystem I and is designated PSI-P
    Anastassia Khrouchtchova
    Plant Biochemistry Laboratory, Department of Plant Biology, The Royal Veterinary and Agricultural University, 40 Thorvaldsensvej, DK 1871 Frederiksberg C, Copenhagen, Denmark
    FEBS Lett 579:4808-12. 2005
    ..The PSI-P protein was not differentially phosphorylated in state 1 and state 2...
  63. ncbi Quenching of chlorophyll triplet states by carotenoids in reconstituted Lhca4 subunit of peripheral light-harvesting complex of photosystem I
    Donatella Carbonera
    Dipartimento di Scienze Chimiche, Universita di Padova, Via Marzolo 1, 35131 Padova, Italy
    Biochemistry 44:8337-46. 2005
    ..Lack of the red forms yields into a reduced efficiency of the triplet quenching in LHC-I thus suggesting that the "red Chls" play a role in enhancing triplet quenching in LHC-I and, possibly, in the whole photosystem I...
  64. ncbi Increased sensitivity of photosynthesis to antimycin A induced by inactivation of the chloroplast ndhB gene. Evidence for a participation of the NADH-dehydrogenase complex to cyclic electron flow around photosystem I
    T Joet
    Commissariat a l Energie Atomique, Cadarache, laboratoire d écophysiologie de la photosynthèse, Département d Ecophysiologie Végétale et Microbiologie, Bât 161, F 13108 Saint Paul lez Durance, France
    Plant Physiol 125:1919-29. 2001
    ..The absence of visible phenotype in ndhB- plants under normal conditions is explained by the complement of these two pathways in the supply of extra-ATP for photosynthesis...
  65. ncbi Quenching of excited states of chlorophyll molecules in submembrane fractions of Photosystem I by exogenous quinones
    Subramanyam Rajagopal
    , , 3351 Boulevard des Forges, Three Rivers, Quebec, Canada GA9 5H7
    Biochim Biophys Acta 1606:147-52. 2003
    ....
  66. ncbi Different kinetics of photoinactivation of photosystem I-mediated electron transport and P700 in isolated thylakoid membranes
    Maya Velitchkova
    Estacion Experimental de Aula Dei, CSIC, Apdo 202, 50080 Zaragoza, Spain
    J Photochem Photobiol B 69:41-8. 2003
    ..In the presence of linear electron transport at 22 degrees C correlation between formation of toxic hydroxyl radicals and inhibition of oxygen uptake was observed...
  67. ncbi Influence of clinorotation on some parameters of photosynthetic apparatus
    O G Volovik
    Institute of Plant Physiology and Genetics Natl. Acad. Sci. of Ukraine, Kyiv, Ukraine
    J Gravit Physiol 8:P45-6. 2001
    ....
  68. ncbi PAA1, a P-type ATPase of Arabidopsis, functions in copper transport in chloroplasts
    Toshiharu Shikanai
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0101, Japan
    Plant Cell 15:1333-46. 2003
    ..Thus, PAA1 is a critical component of a Cu transport system in chloroplasts responsible for cofactor delivery to plastocyanin and Cu/ZnSOD...
  69. ncbi Knock-out of the chloroplast-encoded PSI-J subunit of photosystem I in Nicotiana tabacum
    Andreas Hansson
    Plant Biochemistry Laboratory, Department of Plant Biology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    FEBS J 274:1734-46. 2007
    ..Thus, PSI-J is an important subunit that, together with PSI-F and PSI-N, is required for formation of the plastocyanin-binding domain of PSI. PSI-J is furthermore important for stability or assembly of the PSI complex...
  70. ncbi Inactivation of a plastid evolutionary conserved gene affects PSII electron transport, life span and fitness of tobacco plants
    José Miguel Zapata
    Dpto de Biologia Vegetal, Universidad de Alcala, Edificio de Ciencias, Campus Universitario, 28871 Alcala de Henares, Madrid, Spain
    New Phytol 174:357-66. 2007
    ....
  71. ncbi Interaction of exogenous quinones with membranes of higher plant chloroplasts: modulation of quinone capacities as photochemical and non-photochemical quenchers of energy in Photosystem II during light-dark transitions
    Nikolai G Bukhov
    Departement de Chimie Biologie, Groupe de Recherche en Energie et Information Biomoléculaires, Universite du Quebec a Trois Rivieres, Canada
    Biochim Biophys Acta 1604:115-23. 2003
    ....
  72. ncbi Effects of extracellular pH on the metabolic pathways in sulfur-deprived, H2-producing Chlamydomonas reinhardtii cultures
    Sergey Kosourov
    National Renewable Energy Laboratory, 1617 Cole Blvd, Golden, CO 80401, U.S.A
    Plant Cell Physiol 44:146-55. 2003
    ..Carbon balances demonstrate that alternative metabolic pathways predominate at different pHs, and these depend on whether residual photosynthetic activity is present or not...
  73. ncbi Control of electron transport in photosystem I by the iron-sulfur cluster FX in response to intra- and intersubunit interactions
    Xiao-Min Gong
    Department of Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 278:19141-50. 2003
    ..Based on these and other results, we propose that FX might have a major role in controlling electron transfer through PS I...
  74. ncbi Senescing leaves possess potential for stress adaptation: the developing leaves acclimated to high light exhibit increased tolerance to osmotic stress during senescence
    Sandip K Behera
    School of Life Sciences, Sambalpur University, Jyoti Vihar-768019, Orissa, India
    J Plant Physiol 160:125-31. 2003
    ....
  75. ncbi [Structural-functional organization of chloroplasts in leaves of xantha-702 mutant of Gossypium hirsutum L]
    V G Ladygin
    Tsitologiia 48:537-53. 2006
    ....
  76. ncbi The state transition mechanism - simply depending on light-on and -off in Spirulina platensis
    Heng Li
    Beijing National Laboratory for Molecular Sciences (BNLMS, Photochemistry Laboratory, P. O. Box 101, Institute of Chemistry, Chinese Academy of Sciences, No. 2, 1st North Street, Zhongguancun, Beijing, 100080, P. R. China
    Biochim Biophys Acta 1757:1512-9. 2006
    ..Thus, it can be concluded that the "mobile PBS" is a common rule for light-induced state transition while the "energy spillover" is only a special case when dark condition is involved...
  77. ncbi Localization of the N-terminal domain in light-harvesting chlorophyll a/b protein by EPR measurements
    Gunnar Jeschke
    , Postfach 3148, 55021 Mainz, Germany
    J Biol Chem 280:18623-30. 2005
    ..A similar phosphorylation-induced conformational change of the N-terminal domain has been observed by others in bovine annexin IV which, due to the conformational switch, also loses its membrane-aggregating property...
  78. ncbi CO2 response of cyclic electron flow around PSI (CEF-PSI) in tobacco leaves--relative electron fluxes through PSI and PSII determine the magnitude of non-photochemical quenching (NPQ) of Chl fluorescence
    Chikahiro Miyake
    Research Institute of Innovative Technology for the Earth, 9 2 Kizugawadai, Kizu cho, Soraku gun, Kyoto, 619 0292 Japan
    Plant Cell Physiol 46:629-37. 2005
    ..The main physiological function of CEF-PSI in photosynthesis of higher plants is discussed...
  79. ncbi Brassica rapa plants adapted to microgravity with reduced photosystem I and its photochemical activity
    Shunxing Jiao
    KS St U, Manhattan
    Physiol Plant 122:281-90. 2004
    ....
  80. ncbi The long-wavelength limit of plant photosynthesis
    Hugo Pettai
    Institute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu 51010, Estonia
    FEBS Lett 579:4017-9. 2005
    ..We conclude that extreme long-wavelength chlorophylls may be present in the intact photosystem II antenna system, similarly to photosystem I...
  81. ncbi The stoichiometry of the two photosystems in higher plants revisited
    Da Yong Fan
    Photobioenergetics Group, Research School of Biological Sciences, The Australian National University, Canberra, ACT 0200, Australia
    Biochim Biophys Acta 1767:1064-72. 2007
    ....
  82. ncbi Microgravity effects on thylakoid, single leaf, and whole canopy photosynthesis of dwarf wheat
    G W Stutte
    Space Life Sciences Laboratory, Dynamac Corporation, Mail Code DYN 3 Kennedy Space Center, FL 32899, USA
    Planta 223:46-56. 2005
    ..The reduction in whole chain electron transport (13%), PSII (13%), and PSI (16%) activities observed under saturating light conditions suggests that microgravity-induced responses at the canopy level may occur at higher PPF intensity...
  83. ncbi Competition between linear and cyclic electron flow in plants deficient in Photosystem I
    Simon Hald
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Biochim Biophys Acta 1777:1173-83. 2008
    ..We conclude that, when the concentration of PSI is limiting, cyclic electron flow is still able to compete effectively with linear flow to maintain a high DeltapH to regulate photosynthesis...
  84. ncbi PsbP protein, but not PsbQ protein, is essential for the regulation and stabilization of photosystem II in higher plants
    Kentaro Ifuku
    Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan
    Plant Physiol 139:1175-84. 2005
    ..The present results demonstrated that PsbP, but not PsbQ, is indispensable for the normal PSII function in higher plants in vivo...
  85. ncbi Sensitivity of the photosynthetic apparatus to UV-A radiation: role of light-harvesting complex II-photosystem II supercomplex organization
    Pavlina I Ivanova
    Institute of Biophysics, Bulgarian Academy of Sciences, Acad G Bonchev Str, Bl 21, Sofia 1113, Bulgaria
    Radiat Environ Biophys 47:169-77. 2008
    ..Comparison of membranes with different organization of their LHCII-PSII supercomplex shows that the oligomeric forms of LHCII play a key role for sensitivity to UV-A radiation of the photosynthetic apparatus...
  86. ncbi Adaptation of photosynthesis under iron deficiency in maize
    Samir Sharma
    Department of Biochemistry, Lucknow University, Lucknow 226 007, India
    J Plant Physiol 164:1261-7. 2007
    ..However, electron transport through this part of the chain did not suffer much as a result of photoinhibition, suggesting a defect in the oxidising side of PS II...
  87. ncbi Design and engineering of photosynthetic light-harvesting and electron transfer using length, time, and energy scales
    Dror Noy
    Johnson Research Foundation, Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biochim Biophys Acta 1757:90-105. 2006
    ..Nevertheless, constructions accommodating dense arrays of different cofactors, some well within 1 nm from each other, still presents a significant challenge for protein design...
  88. ncbi Protein composition and native state of pigments of thylakoid membrane of wheat genotypes differently tolerant to water stress
    I M Guseynova
    Institute of Botany, National Academy of Sciences, AZ1073 Baku, Azerbaijan
    Biochemistry (Mosc) 71:173-7. 2006
    ..A shift of the main band from 740-742 to 738 nm is observed in the fluorescence spectra (77 K) of chloroplasts from both genotypes under water deficiency, and there is a stimulation of the ratio of fluorescence band intensity F687/F740...
  89. ncbi Nitrite regulates distribution of excitation energy between the two photosystems by causing state transition
    Archna Sahay
    School of Life Sciences, Devi Ahilya University, Vigyan Bhavan, Khandwa Road, Indore 452001, M.P, India
    Plant Physiol Biochem 44:7-12. 2006
    ..Based on these observations we have suggested a role of nitrite in causing state transition...
  90. ncbi Organization and activity of photosystems in the mesophyll and bundle sheath chloroplasts of maize
    Elzbieta Romanowska
    Department of Plant Physiology, Warsaw University, Miecznikowa 1, 02 096 Warszawa, Poland
    J Plant Physiol 163:607-18. 2006
    ..This in turn suggests the role of PSII for poising the redox state of PSI...
  91. ncbi Biochemical and molecular characterization of photosystem I deficiency in the NCS6 mitochondrial mutant of maize
    Shunxing Jiao
    Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Plant Mol Biol 57:303-13. 2005
    ..The reductions of both nucleus and plastid encoded components indicate that complex interorganellar signaling pathways may be involved...
  92. ncbi Temperature acclimation of photosynthesis and related changes in photosystem II electron transport in winter wheat
    Takenobu Yamasaki
    Department of Biology, Faculty of Science, Toho University, Miyama 2 2 1, Funabashi, Chiba 274 8510, Japan
    Plant Physiol 128:1087-97. 2002
    ..These results indicate that the major factor that contributes to thermal acclimation of photosynthesis in winter wheat is the plastic response of PS II electron transport to environmental temperature...
  93. ncbi Involvement of nitric oxide in light-mediated greening of barley seedlings
    Lingang Zhang
    Key Laboratory of Arid and Grassland Ecology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China
    J Plant Physiol 163:818-26. 2006
    ..These results indicated that NO, as an endogenous signaling molecule, participates in light-mediated greening of barley seedlings, and exogenous NO accelerates this process...
  94. ncbi Alternative photosynthetic electron flow to oxygen in marine Synechococcus
    Shaun Bailey
    The Carnegie Institution, Department of Plant Biology, 260 Panama Street, Stanford, CA 94305, USA
    Biochim Biophys Acta 1777:269-76. 2008
    ..These findings are also discussed in the context of satisfying the energetic requirements of the cell when photosystem I abundance is low...
  95. ncbi A stable LHCII-PSI aggregate and suppression of photosynthetic state transitions in the psae1-1 mutant of Arabidopsis thaliana
    Paolo Pesaresi
    Zentrum zur Identifikation von Genfunktionen durch Insertionsmutagenese bei Arabidopsis thaliana (ZIGIA, , , , Germany
    Planta 215:940-8. 2002
    ....
  96. ncbi Proteomic analysis of a highly active photosystem II preparation from the cyanobacterium Synechocystis sp. PCC 6803 reveals the presence of novel polypeptides
    Yasuhiro Kashino
    Department of Biology, Washington University, One Brookings Drive, St Louis, MO 63130, USA
    Biochemistry 41:8004-12. 2002
    ..This work describes newly identified proteins in a highly purified cyanobacterial PSII preparation that is being widely used to investigate the structure, function, and biogenesis of this photosystem...
  97. ncbi Modulation of photosystem II chlorophyll fluorescence by electrogenic events generated by photosystem I
    A A Bulychev
    Biophysics Department, Faculty of Biology, Moscow State University, Moscow 119899, Russia
    Bioelectrochemistry 54:157-68. 2001
    ..A model is presented that describes modulating effect of the membrane potential on chlorophyll fluorescence and roughly simulates the fluorescence induction curves measured at low and high membrane potentials...
  98. ncbi Differential thermal effects on the energy distribution between photosystem II and photosystem I in thylakoid membranes of a psychrophilic and a mesophilic alga
    Rachael Morgan-Kiss
    Department of Microbiology, University of Illinois, Urbana, IL 61801, USA
    Biochim Biophys Acta 1561:251-65. 2002
    ..The relationship between lipid unsaturation and the functioning of the photosynthetic apparatus under elevated temperatures is discussed...
  99. ncbi Electron flow to photosystem I from stromal reductants in vivo: the size of the pool of stromal reductants controls the rate of electron donation to both rapidly and slowly reducing photosystem I units
    Nikolai Bukhov
    K.A. Timiriazev Institute of Plant Physiology, Russian Academy of Science, Botanicheskaya 35, 127276 Moscow, Russia
    Planta 215:812-20. 2002
    ....
  100. ncbi Interaction of phycobilisomes with photosystem II dimers and photosystem I monomers and trimers in the cyanobacterium Spirulina platensis
    M G Rakhimberdieva
    A. N. Bakh Institute of Biochemistry, Russian Academy of Sciences, Moscow 117071, Russia
    Biochemistry 40:15780-8. 2001
    ..A relevant model of organization of phycobilisomes and chlorophyll pigment-protein complexes in Spirulina is proposed. It is suggested that phycobilisomes are connected with PSII dimers, PSI trimers, and coupled PSI monomers...
  101. ncbi Electrogenic reduction of the primary electron donor P700 by plastocyanin in photosystem I complexes
    M D Mamedov
    Department of Photobiochemistry, A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russia
    FEBS Lett 500:172-6. 2001
    ..A small but detectable fast electrogenic phase was observed at high Pc concentration. The rate constant of this phase was independent of Pc concentration, indicating that it is related to a first-order process...

Research Grants91

  1. FLAVIN-PROTEIN INTERACTIONS IN FLAVOENZYME CATALYSIS
    Gordon Tollin; Fiscal Year: 1993
    ..It is anticipated that these studies will provide new insights into the roles of protein structure in controlling molecular recognition, specificity and rates in biological electron transfer processes...
  2. STRUCTURE/FUNCTION OF PHOTOSYNTHETIC CYTOCHROME COMPLEX
    WILLIAM CRAMER; Fiscal Year: 1993
    ....
  3. Femtosecond nano-crystallography of membrane proteins
    Petra Fromme; Fiscal Year: 2010
    ..The pulses are so brief that they terminate before radiation damage processes can begin. ..
  4. DISTANCE MEASUREMENTS IN METALLOPROTEINS
    GARY BRUDVIG; Fiscal Year: 2002
    ....
  5. 250/500 GHZ GYROTRON BASED DNP/EPR SPECTROMETER
    RICHARD TEMKIN; Fiscal Year: 2003
    ..5-1.0% bandwidth) and advanced pulse formats for EPR studies. We will also extend gyrotron oscillators to 600-800 GHz. Such gyrotrons could be used with future 0.9- 1.2 GHz NMR spectrometers. ..
  6. SPECTROSCOPIC STUDIES OF LIGHT-DRIVEN ELECTRON TRANSFER
    BRIDGETTE BARRY; Fiscal Year: 2007
    ..abstract_text> ..
  7. PHYTOCHROME REGULATION OF SPECIFIC GENE EXPRESSION
    ELAINE TOBIN; Fiscal Year: 1991
    ..To isolate Arabidopsis mutants in the phytochrome response pathway(s) that govern nuclear transcriptional changes and light-dependent germination; and 8. To analyze the recovered mutants both genetically and biochemically...
  8. Disassembly and degradation of Photosystem I
    Kevin Redding; Fiscal Year: 2005
    ....
  9. Supercritical Fluid Extraction for Membrane Proteomics
    Lloyd Smith; Fiscal Year: 2006
    ..The successful development of this new technology for membrane proteomics will address a critical gap in current proteomics efforts. ..
  10. MOLECULAR AND CELLULAR BACTERIAL PATHOGENESIS
    David Briles; Fiscal Year: 2007
    ..The MCBP advisory committee will advise the trainees in their research and training programs and in their search for a job or postdoctoral position at the completion of their MCBP training. ..
  11. Mechanism of Action of Antibody to PspA
    David Briles; Fiscal Year: 2007
    ..Our analyses of the protection-eliciting and non-protection-eliciting epitopes on PspA should make it possible to design even better PspA vaccines in the future. ..
  12. Mechanism of Action of Antibody to PspA
    David Briles; Fiscal Year: 2003
    ..Our analyses of the protection-eliciting and non-protection-eliciting epitopes on PspA should make it possible to design even better PspA vaccines in the future. ..
  13. PROTECTIVE IMMUNITY TO PNEUMOCOCCAL SURFACE PROTEIN A
    David Briles; Fiscal Year: 1993
    ....
  14. PspA: A Potential Pneumococcal Vaccine Component
    David Briles; Fiscal Year: 2009
    ..pneumoniae is important because of the high complexity and cost of the polysaccharide-protein conjugate vaccine and the rapid evolution of pneumococci to evade the capsule-type-specific protection elicited by the conjugate vaccine. ..
  15. REGULATION OF BILIPROTEIN BIOSYNTHESIS IN CYANOBACTERIA
    DONALD BRYANT; Fiscal Year: 1993
    ..PCC 7409 in an attempt to generate at in vitro system for the analysis of transcriptional regulation in cyanobacteria. The studies proposed should greatly extend out knowledge of mechanisms regulating gene expression in photoautotrophs...
  16. New Methodology for Indole Alkaloid Syntheses
    Ken S Feldman; Fiscal Year: 2010
    ..The use of a new variant of the Pummerer reaction to control both oxidation level and reaction site within the indole nucleus forms the basis of this chemistry. ..
  17. Chemical and Biological Studies on Biaryl Phenolics
    Ken Feldman; Fiscal Year: 2005
    ..The search for selective 20S proteosome inhibitors among the Ntn-type proteases will be advanced by these investigations. ..
  18. ALKYNYLIODONIUM SALTS IN ORGANIC SYNTHESIS
    Ken Feldman; Fiscal Year: 2004
    ..Taken together, these studies will introduce new and concise techniques for preparing small polycyclic organic molecules of the type typically sought as pharmaceutical leads. ..
  19. New Methodology for Indole Alkaloid Syntheses
    Ken Feldman; Fiscal Year: 2007
    ..The use of a new variant of the Pummerer reaction to control both oxidation level and reaction site within the indole nucleus forms the basis of this chemistry. ..
  20. RADICAL MEDIATED CYCLIZATION REACTIONS
    Ken Feldman; Fiscal Year: 1993
    ..Successful completion of these syntheses will afford the targets (or analogs) in the most efficient manner to date...
  21. REGULATION OF BILIPROTEIN IN CYANOBACTERIA
    DONALD BRYANT; Fiscal Year: 2002
    ..These last studies could explain bloom disappearance in natural populations and could suggest new approaches for the control of problematic or toxic cyanobacteria in water supplies. ..