Genomes and Genes
electron transport complex iv
Summary: A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.
Publications281 found, 100 shown here
- DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebratesO Folmer
Center for Theoretical and Applied Genetics, Rutgers University, New Brunswick, New Jersey 08903 231
Mol Mar Biol Biotechnol 3:294-9. 1994..Preliminary comparisons revealed that these COI primers generate informative sequences for phylogenetic analyses at the species and higher taxonomic levels...
- Biological identifications through DNA barcodesPaul D N Hebert
Department of Zoology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
Proc Biol Sci 270:313-21. 2003..Its assembly will also generate important new insights into the diversification of life and the rules of molecular evolution...
- DNA barcoding and taxonomy in Diptera: a tale of high intraspecific variability and low identification successRudolf Meier
Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, Singapore
Syst Biol 55:715-28. 2006..We conclude with an outlook on the prospects of obtaining complete barcode databases and the future use of DNA sequences in a modern integrative taxonomy...
- Identification of Birds through DNA BarcodesPaul D N Hebert
Department of Zoology, University of Guelph, Guelph, Ontario, Canada
PLoS Biol 2:e312. 2004..The growing evidence for the effectiveness of DNA barcodes as a basis for species identification supports an international exercise that has recently begun to assemble a comprehensive library of COI sequences linked to named specimens...
- DNA barcodes reveal cryptic host-specificity within the presumed polyphagous members of a genus of parasitoid flies (Diptera: Tachinidae)M Alex Smith
Biodiversity Institute of Ontario, University of Guelph, Guelph, ON, Canada N1G 2W1
Proc Natl Acad Sci U S A 103:3657-62. 2006..If general, these results will increase estimates of global species richness and imply that tropical conservation and host-parasite interactions may be more complex than expected...
- HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cellsRyo Fukuda
Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 129:111-22. 2007..Thus, mammalian cells respond to hypoxia by altering COX subunit composition, as previously observed in yeast, but by a completely different molecular mechanism...
- DNA barcoding Australia's fish speciesRobert D Ward
CSIRO Marine and Atmospheric Research, GPO Box 1538, Hobart, Tasmania 7001, Australia
Philos Trans R Soc Lond B Biol Sci 360:1847-57. 2005..We conclude that cox1 sequencing, or 'barcoding', can be used to identify fish species...
- The campaign to DNA barcode all fishes, FISH-BOLR D Ward
CSIRO Wealth from Oceans Flagship, CSIRO Marine and Atmospheric Research, GPO Box 1538, Hobart, Tasmania 7001, Australia
J Fish Biol 74:329-56. 2009..However, current results indicate these issues are of little concern for the great majority of specimens...
- mtDNA mutations increase tumorigenicity in prostate cancerJohn A Petros
Department of Urology, Emory University, 1365A Clifton Road, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 102:719-24. 2005..The mutant tumors also generated significantly more ROS. Therefore, mtDNA mutations do play an important role in the etiology of prostate cancer...
- Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's diseaseJia Yao
Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
Proc Natl Acad Sci U S A 106:14670-5. 2009..Mitochondrial dysfunction provides a plausible mechanistic rationale for the hypometabolism in brain that precedes AD diagnosis and suggests therapeutic targets for prevention of AD...
- The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 AT Tsukihara
Institute for Protein Research, Osaka University, Suita, Japan
Science 272:1136-44. 1996..Possible channels for chemical protons to produce H2O, for removing the produced water, and for O2, respectively, were identified...
- A universal DNA mini-barcode for biodiversity analysisIsabelle Meusnier
Biodiversity Institute of Ontario, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
BMC Genomics 9:214. 2008..It may be difficult in practice, however, to retrieve a 650 bp fragment from archival specimens, (because of DNA degradation) or from environmental samples (where universal primers are needed)...
- Co-translational membrane insertion of mitochondrially encoded proteinsMartin Ott
Cell Biology, University of Kaiserslautern, 67663 Kaiserslautern, Germany
Biochim Biophys Acta 1803:767-75. 2010..The specific hallmarks and the critical components of this machinery are discussed in this review article...
- Rcf1 and Rcf2, members of the hypoxia-induced gene 1 protein family, are critical components of the mitochondrial cytochrome bc1-cytochrome c oxidase supercomplexVera Strogolova
Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin, USA
Mol Cell Biol 32:1363-73. 2012..Based on our findings, we propose a model where the Hig1 proteins regulate the COX enzyme activity through Cox3 and associated Cox12 protein, in a manner that may be influenced by the neighboring AAC proteins...
- Mitochondrial cox1 sequence data reliably uncover patterns of insect diversity but suffer from high lineage-idiosyncratic error ratesLars Hendrich
Department of Entomology, Zoological State Collection, Munich, Germany
PLoS ONE 5:e14448. 2010..Then, we contrasted phylogenetic subsampling with the hitherto more commonly applied geographical subsampling, where sister species are not necessarily captured...
- Inventory control: cytochrome c oxidase assembly regulates mitochondrial translationDavid U Mick
Abteilung für Biochemie II, Universitat Gottingen, D 37073 Gottingen, Germany
Nat Rev Mol Cell Biol 12:14-20. 2011..New findings on the early steps of cytochrome c oxidase assembly reveal how the mitochondrial translation of its core component, cytochrome c oxidase subunit 1 (Cox1), is directly coupled to the assembly of this respiratory complex...
- Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathwayTakayuki Akimoto
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 280:19587-93. 2005..These findings suggest that contractile activity-induced activation of the p38 MAPK pathway promotes Pgc-1alpha gene expression and skeletal muscle adaptation...
- Taenia asiatica and Taenia saginata: genetic divergence estimated from their mitochondrial genomesH K Jeon
Department of Parasitology and Medical Research Institute, Chungbuk National University College of Medicine, Chongju, Chungbuk 361 763, Republic of Korea
Exp Parasitol 113:58-61. 2006..8%. The actual sequence divergence was computed 4.5% from the cox1 gene, and 4.1% from the cob gene. These results support the designation of T. asiatica as a separate species from T. saginata...
- DNA barcodes distinguish species of tropical LepidopteraMehrdad Hajibabaei
Department of Integrative Biology, University of Guelph, Guelph, ON, Canada N1G 2W1
Proc Natl Acad Sci U S A 103:968-71. 2006..If these results are general, DNA barcoding will significantly aid species identification and discovery in tropical settings...
- A ranking system for reference libraries of DNA barcodes: application to marine fish species from PortugalFilipe O Costa
CBMA Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, Braga, Portugal
PLoS ONE 7:e35858. 2012..We propose a ranking system to attribute a confidence level to species identifications associated with DNA barcode records from a RLDB. Here we apply the proposed ranking system to a newly generated RLDB for marine fish of Portugal...
- Neotropical bats: estimating species diversity with DNA barcodesElizabeth L Clare
Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada
PLoS ONE 6:e22648. 2011..Our analysis provides strong support for the continued assembly of DNA barcoding libraries and ongoing taxonomic investigation of bats...
- Slow mitochondrial DNA sequence evolution in the Anthozoa (Cnidaria)T L Shearer
Department of Biological Sciences, 109 Cooke Hall, University at Buffalo, Buffalo, NY 14260, USA
Mol Ecol 11:2475-87. 2002..Slow evolution and unique characteristics may be common in primitive metazoans, suggesting that patterns of mtDNA evolution in these organisms differ from that in other animal systems...
- Cryptic diversity in Indo-Pacific coral-reef fishes revealed by DNA-barcoding provides new support to the centre-of-overlap hypothesisNicolas Hubert
Laboratoire ECOMAR, Faculté des Sciences et Technologies, Universite de la Reunion, Saint Denis, Reunion, France
PLoS ONE 7:e28987. 2012....
- The role of the LRPPRC (leucine-rich pentatricopeptide repeat cassette) gene in cytochrome oxidase assembly: mutation causes lowered levels of COX (cytochrome c oxidase) I and COX III mRNAFenghao Xu
Metabolism Research Programme, The Research Institute, The Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada M5G 1X8
Biochem J 382:331-6. 2004..A more diffuse distribution of LRPPRC in LSFC cells compared with controls was evident when viewed by immunofluorescence microscopy, with less LRPPRC present in peripheral mitochondria...
- p53 regulates mitochondrial respirationSatoaki Matoba
Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Science 312:1650-3. 2006..That SCO2 couples p53 to mitochondrial respiration provides a possible explanation for the Warburg effect and offers new clues as to how p53 might affect aging and metabolism...
- Arrangement of the respiratory chain complexes in Saccharomyces cerevisiae supercomplex III2IV2 revealed by single particle cryo-electron microscopyEugenia Mileykovskaya
Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, Texas 77030, USA
J Biol Chem 287:23095-103. 2012..The supercomplex contains about 50 molecules of cardiolipin (CL) with a fatty acid composition identical to that of the inner membrane CL pool, consistent with CL-dependent stabilization of the supercomplex...
- Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylationDaniel J M Fernández-Ayala
Institute of Medical Technology, Tampere University Hospital, University of Tampere, 33014 Tampere, Finland
Cell Metab 9:449-60. 2009..AOX appears to offer promise as a wide-spectrum therapeutic tool in OXPHOS disorders...
- Molecular prospecting for cryptic species of nematodes: mitochondrial DNA versus internal transcribed spacerMichael S Blouin
Department of Zoology, Oregon State University, Corvallis, OR 97331, USA
Int J Parasitol 32:527-31. 2002..On the other hand, internal transcribed spacer remains an excellent tool for DNA diagnostics (quickly distinguishing between known species) owing to its lower level of intraspecific polymorphism...
- Regulation of oxidative phosphorylation, the mitochondrial membrane potential, and their role in human diseaseMaik Huttemann
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Bioenerg Biomembr 40:445-56. 2008..This model is presented in light of the recently emerging understanding of mechanisms that regulate mammalian cytochrome c oxidase and its substrate cytochrome c as representative enzymes for the entire OxPhos system...
- Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidaseB Kadenbach
Fachbereich Chemie, Philipps Universitat, Marburg, Germany
Free Radic Biol Med 29:211-21. 2000..High substrate pressure (sigmoidal v/s kinetics), palmitate and 3,5-diiodothyronine (binding to subunit Va) increase also delta p, ROS production and slip but without dephosphorylation of COX...
- Biogenesis and assembly of eukaryotic cytochrome c oxidase catalytic coreIleana C Soto
Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Biochim Biophys Acta 1817:883-97. 2012..This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes...
- Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7bDaniela Fornuskova
Department of Pediatrics, First Faculty of Medicine, Charles University in Prague, Ke Karlovu 2, Prague 2, 12808 Czech Republic
Biochem J 428:363-74. 2010....
- Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly geneL C Papadopoulou
Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, Thessaloniki, Macedonia, Greece
Nat Genet 23:333-7. 1999..The clinical phenotype caused by mutations in human SCO2 differs from that caused by mutations in SURF1, the only other known COX assembly gene associated with a human disease, Leigh syndrome...
- A comprehensive DNA sequence library is essential for identification with DNA barcodesTorbjørn Ekrem
Section of Natural History, Museum of Natural History and Archaeology, Norwegian University of Science and Technology, NO 7491 Trondheim, Norway
Mol Phylogenet Evol 43:530-42. 2007..Thus, if a well-matching cox1 sequence is not already available in the library, the prospects of approximately identifying an unknown taxon, even to the correct genus of subtribe Tanytarsina, are not good...
- Cytochrome c oxidase--structure, function, and physiology of a redox-driven molecular machineO M H Richter
Institute of Biochemistry, Biocenter, J W Goethe Universitat, Marie Curie Str 9, 60439 Frankfurt, Germany
Rev Physiol Biochem Pharmacol 147:47-74. 2003..Moreover, the successful elucidation of 3-D structures for both the mitochondrial and several bacterial oxidases has greatly helped in designing mutagenesis approaches to study functional aspects in these enzymes...
- Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidaseMargaret T T Wong-Riley
Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Biol Chem 280:4761-71. 2005..The results are consistent with our hypothesis that the mechanism of photobiomodulation involves the up-regulation of cytochrome c oxidase, leading to increased energy metabolism in neurons functionally inactivated by toxins...
- Patterns of evolution of mitochondrial cytochrome c oxidase I and II DNA and implications for DNA barcodingAmanda D Roe
CW403 Biological Sciences Building, Department of Biological Sciences, University of Alberta, Edmonton, Alta, Canada
Mol Phylogenet Evol 44:325-45. 2007..Consequently, we recommend that researchers should maximize sequence length to increase the probability of sampling regions of high phylogenetic informativeness, and to minimize stochastic variation in estimating total divergence...
- Rapid diagnostic PCR assays for members of the Culicoides obsoletus and Culicoides pulicaris species complexes, implicated vectors of bluetongue virus in EuropeDamien V Nolan
School of Biological Sciences, University of Aberdeen, Zoology Building, Tillydrone Avenue, Aberdeen AB24 2TZ, Scotland, UK
Vet Microbiol 124:82-94. 2007..pulicaris complex or in a multiplex PCR to identify members of the C. obsoletus complex. This approach provides a valuable diagnostic tool for monitoring species composition in mixed field collections of Culicoides...
- A three-gene dinoflagellate phylogeny suggests monophyly of prorocentrales and a basal position for amphidinium and heterocapsaHuan Zhang
Department of Marine Sciences, University of Connecticut, Groton, CT 06340, USA
J Mol Evol 65:463-74. 2007..The position of these lineages needs to be further verified...
- Genetic patterns across multiple introductions of the globally invasive crab genus CarcinusJohn A Darling
US Environmental Protection Agency, National Exposure Research Laboratory, Molecular Ecology Research Branch, Cincinnati, OH 45268, USA
Mol Ecol 17:4992-5007. 2008..maenas invasions vary broadly in the degree to which they retain genetic diversity, although populations with the least variation typically derive from secondary invasions or from introductions that occurred more than 100 years ago...
- Slow mitochondrial COI sequence evolution at the base of the metazoan tree and its implications for DNA barcodingDanwei Huang
Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore
J Mol Evol 66:167-74. 2008..Caution is also advised for Porifera and Hydrozoa because of relatively low identification success rates as even threshold divergence that maximizes the "barcoding gap" does not improve identification success...
- The low-spin heme of cytochrome c oxidase as the driving element of the proton-pumping processTomitake Tsukihara
Institute for Protein Research, Osaka University, 3 2 Yamada Oka, Suita 565 0871, Japan
Proc Natl Acad Sci U S A 100:15304-9. 2003..Infrared results indicate that the conformation of Asp-51 is controlled only by the oxidation state of the low-spin heme. These results indicate that the low-spin heme drives the proton-pumping process...
- Barcoding aphids (Hemiptera: Aphididae) of the Korean Peninsula: updating the global data setWonhoon Lee
Insect Biosystematics Laboratory, Research Institute for Agricultural and Life Sciences, Department of Agricultural Biotechnology, Seoul National University, Seoul 151 921, Korea
Mol Ecol Resour 11:32-7. 2011..Based on these results, we conclude that DNA barcodes can provide an effective tool for identifying aphid species in such applications as pest management, monitoring and plant quarantine...
- Species within the Bemisia tabaci (Hemiptera: Aleyrodidae) complex in soybean and bean crops in ArgentinaV Alemandri
Instituto de Fitopatología y Fisiología Vegetal Instituto Nacional de Tecnología Agropecuaria IFFIVE INTA, Camino 60 cuadras Km 5 1 2, X5020ICA Córdoba, Argentina
J Econ Entomol 105:48-53. 2012..These primers were either unable to distinguish between the two indigenous members of the complex in Argentina or indicated a difference when none was evident on the basis of mtCOI sequence comparison...
- Cytochrome C oxidase activity and oxygen toleranceJian Li Campian
Molecular Targets Group, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
J Biol Chem 282:12430-8. 2007..These observations may suggest new pharmaceutical strategies to diminish oxygen-mediated cellular damage...
- Identifying Canadian mosquito species through DNA barcodesA Cywinska
Department of Biological Sciences, Brock University, St Catharines, Ontario, Canada
Med Vet Entomol 20:413-24. 2006..4% (range 0.2-17.2%), whereas those for conspecific individuals averaged 0.5% (range 0.0-3.9%)...
- Probing evolutionary patterns in neotropical birds through DNA barcodesKevin C R Kerr
Department of Integrative Biology, Biodiversity Institute of Ontario, University of Guelph, Guelph, Ontario, Canada
PLoS ONE 4:e4379. 2009..This study begins to address this gap by assembling a library of mitochondrial COI sequences, or DNA barcodes, for Argentinian birds and comparing their patterns of genetic diversity to those of North American birds...
- Cryptic ecological diversification of a planktonic estuarine copepod, Acartia tonsaGang Chen
Department of Biology, University of Maryland, College Park, MD 20742, USA
Mol Ecol 17:1451-68. 2008....
- Discrimination of Culicoides midge larvae using multiplex polymerase chain reaction assays based on DNA sequence variation at the mitochondrial cytochrome C oxidase I geneJan M Schwenkenbecher
Institute of Biological and Environmental Sciences, University of Aberdeen, Zoology Building, Tillydrone Avenue, Aberdeen AB24 2TZ, United Kingdom
J Med Entomol 46:610-4. 2009..l. complex. These assays yield two PCR products: one species-specific and one generic band. We show the application of the assays in the analysis of Culicoides larvae from three different farms in northeast Scotland...
- Phylogeography of Aedes (Stegomyia) aegypti (L.) and Aedes (Stegomyia) albopictus (Skuse) (Diptera: Culicidae) based on mitochondrial DNA variationsLaurence Mousson
Insectes et Maladies Infectieuses formerly Ecologie des Systèmes Vectoriels, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
Genet Res 86:1-11. 2005..This suggests that African populations of A. aegypti introduced during the slave trade have persisted in Boa Vista, resisting eradication campaigns...
- The proton pumping pathway of bovine heart cytochrome c oxidaseKunitoshi Shimokata
Department of Biochemistry and Integrative Medical Biology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Proc Natl Acad Sci U S A 104:4200-5. 2007..These results significantly strengthen the proposal that H-pathway is involved in proton pumping...
- Phylogeography and genetic diversity of a widespread Old World butterfly, Lampides boeticus (Lepidoptera: Lycaenidae)David J Lohman
Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Republic of Singapore
BMC Evol Biol 8:301. 2008..Here, we investigate the demographic history and taxonomic status of this widespread species, and screen for the presence or absence of the bacterial endosymbiont Wolbachia...
- Mutations in C12orf62, a factor that couples COX I synthesis with cytochrome c oxidase assembly, cause fatal neonatal lactic acidosisWoranontee Weraarpachai
Department of Human Genetics and Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Am J Hum Genet 90:142-51. 2012..We conclude that C12orf62 is required for coordination of the early steps of COX assembly with the synthesis of COX I...
- Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 geneEyal Shteyer
The Metabolic Disease Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Am J Hum Genet 84:412-7. 2009..Mutation analysis of COX4I2 is warranted in patients with malabsorption due to exocrine pancreatic insufficiency and in patients with dyserythropoeitic anemia...
- Solution structure of Sco1: a thioredoxin-like protein Involved in cytochrome c oxidase assemblyErica Balatri
Magnetic Resonance Center CERM and Department of Chemistry, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Florence, Italy
Structure 11:1431-43. 2003..The availability of the structure has allowed us to model the homologs Sco1 and Sco2 from S. cerevisiae and to discuss the physiological role of the Sco family...
- Activity-based protein profiling reveals mitochondrial oxidative enzyme impairment and restoration in diet-induced obese miceNatalie C Sadler
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
PLoS ONE 7:e47996. 2012....
- Mechanism of Cu(A) assemblyLuciano A Abriata
Instituto de Biologia Molecular y Celular de Rosario, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK Rosario, Argentina
Nat Chem Biol 4:599-601. 2008..The purported metallochaperone Sco1 is unable to deliver copper ions; instead, it works as a thiol-disulfide reductase to maintain the correct oxidation state of the Cu(A) cysteine ligands...
- Comparative phylogeography among hydrothermal vent species along the East Pacific Rise reveals vicariant processes and population expansion in the SouthS Plouviez
Laboratoire Adaptation et Diversité en Milieu Marin, Universite Pierre et Marie Curie Paris 6, Paris, France
Mol Ecol 18:3903-17. 2009....
- A histidine residue acting as a controlling site for dioxygen reduction and proton pumping by cytochrome c oxidaseKazumasa Muramoto
Department of Life Science, University of Hyogo, 3 2 1 Kouto, Kamigori, Ako, Hyogo 678 1297, Japan
Proc Natl Acad Sci U S A 104:7881-6. 2007..These results suggest that His-503 couples the proton transfer for dioxygen reduction with the proton pumping...
- Peripatric speciation drives diversification and distributional pattern of reef hermit crabs (Decapoda: Diogenidae: Calcinus)Maria Celia Machel D Malay
Florida Museum of Natural History and Department of Biology, University of Florida, Gainesville, Florida 32611, USA
Evolution 64:634-62. 2010..Calcinus speciation patterns do not match well-worn models put forth to explain the origin of Indo-West Pacific diversity, but underscore the complexity of marine diversification...
- Cox25 teams up with Mss51, Ssc1, and Cox14 to regulate mitochondrial cytochrome c oxidase subunit 1 expression and assembly in Saccharomyces cerevisiaeFlavia Fontanesi
Departments of Neurology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
J Biol Chem 286:555-66. 2011..These results suggest that once Ssc1-Mss51 are released from the Cox1 stabilization complex, Cox25 continues to interact with Cox14 and Cox1 to facilitate the formation of multisubunit COX assembly intermediates...
- Cytochrome c oxidase: evolution of control via nuclear subunit additionDenis Pierron
Wayne State University School of Medicine, Detroit, MI, USA
Biochim Biophys Acta 1817:590-7. 2012....
- DNA barcodes for two scale insect families, mealybugs (Hemiptera: Pseudococcidae) and armored scales (Hemiptera: Diaspididae)D S Park
Biological Resource Center, KRIBB, Daejeon, Korea
Bull Entomol Res 101:429-34. 2011....
- A comprehensive molecular survey of Echinococcus granulosus in formalin-fixed paraffin-embedded tissues in human isolates in TurkeySami Simsek
Department of Parasitology, Faculty of Veterinary Medicine, University of Firat, 23119 Elazig, Turkey
Parasitol Res 109:411-6. 2011..In conclusion, the results from the analysis of human isolates of E. granulosus confirmed the occurrence of G1, G3 and G6 genotypes in Turkey and indicated G1/G3 cluster (E. granulosus sensu stricto) as the predominant genotype...
- Proton-pumping mechanism of cytochrome C oxidaseShinya Yoshikawa
Department of Life Science, University of Hyogo, Hyogo, Japan
Annu Rev Biophys 40:205-23. 2011..Here, recent progress in experimental evaluations of these proposals is reviewed and strategies for improving our understanding of the mechanism of this physiologically important process are discussed...
- The O(2) reduction and proton pumping gate mechanism of bovine heart cytochrome c oxidaseShinya Yoshikawa
Department of Life Science, University of Hyogo, Hyogo, Japan
Biochim Biophys Acta 1807:1279-86. 2011..This article is part of a Special Issue entitled: Allosteric cooperativity in respiratory proteins...
- Molecular approach to the identification of fish in the South China SeaJunbin Zhang
Department of Aquaculture and Life Science, Shanghai Ocean University, Shanghai, China
PLoS ONE 7:e30621. 2012..As a contribution to FISH-BOL, we examined the degree to which DNA barcoding can discriminate marine fishes from the South China Sea...
- Multiple phosphorylations of cytochrome c oxidase and their functionsStefan Helling
Medizinisches Proteom Center, Funktionelle Proteomik, Ruhr Universitat Bochum, Bochum, Germany
Proteomics 12:950-9. 2012..We therefore hypothesize that additional phosphorylation(s) may be required for the "allosteric ATP-inhibition," and that these sites may be easily dephosphorylated or difficult to identify by mass spectrometry...
- Phylogeography and biogeography concordance in the marine gastropod Crepipatella dilatata (Calyptraeidae) along the southeastern Pacific coastAntonio Brante
Departamento de Ecologia, Facultad de Ciencias, Universidad Católica de la Santísima Concepción, Concepcion, Chile
J Hered 103:630-7. 2012..In addition, in this and other marine invertebrate species, gene flow limitations across both sides of the 30°S break may act as a driver of the speciation process...
- Assessment of three mitochondrial genes (16S, Cytb, CO1) for identifying species in the Praomyini tribe (Rodentia: Muridae)Violaine Nicolas
Museum national d histoire naturelle, Département de Systématique et Evolution UMR CNRS 7205, Paris, France
PLoS ONE 7:e36586. 2012....
- Molecular evolution at the cytochrome oxidase subunit 2 gene among divergent populations of the intertidal copepod, Tigriopus californicusPaul D Rawson
School of Marine Sciences, University of Maine, Orono, ME 04469, USA
J Mol Evol 62:753-64. 2006....
- Molecular comparison of topotypic specimens confirms Anopheles (Nyssorhynchus) dunhami Causey (Diptera: Culicidae) in the Colombian AmazonFreddy Ruiz
Division of Entomology, Walter Reed Army Institute of Research, 503 Robert Grant Av, Maryland 20910, USA
Mem Inst Oswaldo Cruz 105:899-903. 2010..dunhami and differentiation from these closely related species are highly robust using either DNA ITS2 sequences or COI DNA barcode. DNA methods are advocated for future differentiation of these often sympatric taxa in South America...
- Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondriaDavid U Mick
Institut fur Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Universitat Freiburg, D 79104 Freiburg, Germany
J Cell Biol 191:141-54. 2010..Our data indicate that Coa1 binding to sequestered Mss51 in complex with Cox14, Coa3, and Cox1 is essential for full inactivation...
- Cardiolipin biosynthesis and mitochondrial respiratory chain function are interdependentVishal M Gohil
Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
J Biol Chem 279:42612-8. 2004..This is the first report of regulation of phospholipid biosynthesis by alteration of subcellular compartment pH...
- Analysis of Leigh syndrome mutations in the yeast SURF1 homolog reveals a new member of the cytochrome oxidase assembly factor familyMegan Bestwick
University of Utah Health Sciences Center, Department of Medicine, Salt Lake City, Utah 84132, USA
Mol Cell Biol 30:4480-91. 2010..Cyc1 is known to be important at an ill-defined step in the assembly and/or stability of CcO. This new link to Coa4 may begin to further elucidate the role of Cyc1 in CcO biogenesis...
- Long-term high-fat-diet feeding impairs mitochondrial biogenesis in liver of male and female ratsAntònia Nadal-Casellas
Grup de Metabolisme Energetic i Nutricio, Departament de Biologia Fonamental i Ciencies de la Salut, Institut Universitari d Investigacio en Ciencies de la Salut IUNICS, Universitat de les Illes Balears, Palma de Mallorca, Spain
Cell Physiol Biochem 26:291-302. 2010..Given the sexual dimorphism previously found in mitochondrial function, the aim of this study was to investigate the gender-dependent effect of chronic high-fat-diet (HFD) feeding on rat liver mitochondrial function and biogenesis...
- Analysis of genetic variability within Thelazia callipaeda (Nematoda: Thelazioidea) from Europe and Asia by sequencing and mutation scanning of the mitochondrial cytochrome c oxidase subunit 1 geneD Otranto
Department of Animal Health and Welfare, University of Bari, Faculty of Veterinary Medicine, P O Box 7, Str Prov per Casamassima Km3, 70010 Valenzano, Bari, Italy
Mol Cell Probes 19:306-13. 2005..The results for the SSCP analysis and sequencing were concordant, indicating that the mutation scanning approach provides a useful tool for investigating the population genetics and molecular ecology of T. callipaeda...
- NADH dehydrogenase subunit 1 and cytochrome c oxidase subunit I sequences compared for members of the genus Taenia (Cestoda)R B Gasser
Department of Veterinary Science, The University of Melbourne, Werribee, Victoria, Australia
Int J Parasitol 29:1965-70. 1999..hydatigena and T. pisiformis (of canids) or T. taeniaeformis (of cats). The NADH dehydrogenase subunit 1 sequence data may prove useful in studies of the systematics and population genetic structure of the Taeniidae...
- The role of PGC-1alpha on mitochondrial function and apoptotic susceptibility in musclePeter J Adhihetty
School of Kinesiology and Health Science, York Univ, Toronto, Ontario, M3J 1P3, Canada
Am J Physiol Cell Physiol 297:C217-25. 2009....
- A mutation in C2orf64 causes impaired cytochrome c oxidase assembly and mitochondrial cardiomyopathyMerei Huigsloot
Nijmegen Center for Mitochondrial Disorders, Department of Pediatrics, Radboud University Nijmegen Medical Centre, PO Box 9101, NL 6500HB, Nijmegen, The Netherlands
Am J Hum Genet 88:488-93. 2011....
- Exploring the use of cytochrome oxidase c subunit 1 (COI) for DNA barcoding of free-living marine nematodesSofie Derycke
Marine Biology Research Group, Department of Biology, Ghent University, Ghent, Belgium
PLoS ONE 5:e13716. 2010..Therefore, we investigate the amplification and sequencing success of two partitions of the COI gene, the M1-M6 barcoding region and the I3-M11 partition...
- Molecular characterization of Swiss Ceratopogonidae (Diptera) and evaluation of real-time PCR assays for the identification of Culicoides biting midgesClaudia E Wenk
Institute of Parasitology, University of Zurich, Winterthurerstr 266a, 8057 Zurich, Switzerland
Vet Parasitol 184:258-66. 2012..Primers and probes of this study were devised to be suitable for multiplexed assays but these evaluations await to be performed...
- Trypanosoma cruzi I-III in southern Brazil causing individual and mixed infections in humans, sylvatic reservoirs and triatominesNilce Gomes Abolis
Laboratório de Parasitologia Humana, Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringa, Av Colombo 5790, Parana, Brazil
Acta Trop 120:167-72. 2011..cruzi I. Four isolates from triatomines showed patterns of both T. cruzi I and II, indicating mixed infections. This study contributes to the characterisation of the dynamics of T. cruzi populations in southern Brazil...
- Differentiation of Culicoides obsoletus and Culicoides scoticus (Diptera: Ceratopogonidae) based on mitochondrial cytochrome oxidase subunit IN Pages
Fundació CReSA Entomologia, Universitat Autonoma de Barcelona, Campus de Bellaterra, Spain
J Med Entomol 42:1026-34. 2005..The species-specific PCR diagnostic was compared with morphological discrimination of C. obsoletus and C. scoticus females. The morphologic characters were not fully reliable...
- Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic miceNatasa Dragicevic
Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, USA
J Alzheimers Dis 20:S535-50. 2010..Therapeutics that target this cascade could be beneficial in the treatment of AD...
- Identification of tyrosine-phosphorylated proteins of the mitochondrial oxidative phosphorylation machineryO Augereau
Physiopathologie Mitochondriale, INSERM U688, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
Cell Mol Life Sci 62:1478-88. 2005..The tyrosine phosphatase PTP 1B was found in brain but not in muscle, heart or liver mitochondria. Our results suggest that tyrosine kinases and phosphatases are involved in the regulation of oxidative phosphorylation...
- Molecular approaches to identify cryptic species and polymorphic species within a complex community of fig waspsJin Hua Xiao
Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
PLoS ONE 5:e15067. 2010..e. NUMTs, or the effects of Wolbachia infections. The analyses suggest that combining multiple markers is the best choice for inferring species identifications as any one marker may be unsuitable in a given case...
- The brain metabolic enhancer methylene blue improves discrimination learning in ratsKathryn M Wrubel
Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA
Pharmacol Biochem Behav 86:712-7. 2007....
- Design and applicability of DNA arrays and DNA barcodes in biodiversity monitoringMehrdad Hajibabaei
Biodiversity Institute of Ontario, Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada
BMC Biol 5:24. 2007..DNA arrays (micro and macro) and DNA barcodes are two molecular approaches that have recently garnered much attention. Here, we compare these two platforms for identification of an important group, the mammals...
- The phylogeny of the Schistosomatidae based on three genes with emphasis on the interrelationships of Schistosoma Weinland, 1858A E Lockyer
Department of Zoology, The Natural History Museum, Cromwell Road, London SW7 5BD, UK
Parasitology 126:203-24. 2003..ocellata and T. szidati, seem to be synonymous. The position of Orientobilharzia within the Schistosoma is confirmed, as is an Asian origin for the Schistosoma, followed by subsequent dispersal through India and Africa...
- Regional brain metabolism with cytochrome c oxidase histochemistry in a PS1/A246E mouse model of autosomal dominant Alzheimer's disease: correlations with behavior and oxidative stressCatherine Strazielle
INSERM, U954, Faculty of Medicine, Vandoeuvre les Nancy, 54500, France
Neurochem Int 55:806-14. 2009....
- Reconstructing mammalian phylogenies: a detailed comparison of the cytochrome B and cytochrome oxidase subunit I mitochondrial genesShanan S Tobe
Centre for Forensic Science, WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, United Kingdom
PLoS ONE 5:e14156. 2010..Using a Kimura 2-parameter p-distance (x100) threshold of 1.5-2.5, cyt b gives a better resolution for separating species with a lower false positive rate and higher positive predictive value than those of COI...
- A phylogenetic analysis of filarial nematodes: comparison with the phylogeny of Wolbachia endosymbiontsM Casiraghi
Istituto di Patologia Generale Veterinaria, , Italy
Parasitology 122:93-103. 2001..and Wuchereria spp.) and the sister group relationship of Dirofilaria spp. and Onchocerca spp. However, the placement of the Wolbachia-free filaria Acanthocheilonema viteae is ambiguous and dependent on the phylogenetic methods used...
- Identifying Fishes through DNA Barcodes and MicroarraysMarc Kochzius
Centre for Applied Gene Sensor Technology, FB2 UFT, University of Bremen, Bremen, Germany
PLoS ONE 5:e12620. 2010..Species identification is a key problem throughout the life cycle of fishes: from eggs and larvae to adults in fisheries research and control, as well as processed fish products in consumer protection...
- Endurance training and detraining in mitochondrial myopathies due to single large-scale mtDNA deletionsTanja Taivassalo
Department of Kinesiology, McGill University, Montreal, Quebec, Canada
Brain 129:3391-401. 2006..The effects of detraining clearly implicate physical inactivity as an important mechanism in reducing exercise capacity and quality of life in patients with mitochondrial myopathy...
- Comparative genotyping of Echinococcus granulosus infecting buffalo in Iran using cox1 geneArash Amin Pour
Department of Parasitology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Parasitol Res 108:1229-34. 2011....
- Towards a global barcode library for Lymantria (Lepidoptera: Lymantriinae) tussock moths of biosecurity concernJeremy R deWaard
Forest Sciences, University of British Columbia, Vancouver, British Columbia, Canada
PLoS ONE 5:e14280. 2010....
- MIR-210 modulates mitochondrial respiration in placenta with preeclampsiaS Muralimanoharan
Center for Pregnancy and Newborn Research, Dept of Ob Gyn, University of Texas Health Science Center, San Antonio, TX 78229, USA
Placenta 33:816-23. 2012..These data collectively suggest that miR-210 overexpression during PE could be responsible for placental mitochondria dysfunction...
- Knockdown of human COX17 affects assembly and supramolecular organization of cytochrome c oxidaseC Oswald
Institute of Genetics, Dresden University of Technology, 01062 Dresden, Germany
J Mol Biol 389:470-9. 2009..An interdependent assembly scenario for the formation of supercomplexes that rather requires the coordinated synthesis and association of individual complexes, is proposed...
- Taxonomy. Will DNA bar codes breathe life into classification?Eliot Marshall
Science 307:1037. 2005
- Low doses of insulin-like growth factor-I induce mitochondrial protection in aging ratsJuan E Puche
Department of Medical Physiology, School of Medicine, University CEU Universidad San Pablo, Boadilla del Monte, 28668, Madrid, Spain
Endocrinology 149:2620-7. 2008..In conclusion, these results show that the cytoprotective effect of IGF-I is closely related to a mitochondrial protection, leading to reduce free radical production, oxidative damage, and apoptosis, and to increased ATP production...
- Nanoelectrode arrays for study of the molecular mechanisms, triggers, and inhibitPeter J Burke; Fiscal Year: 2012..A high throughput technology to monitor P in mitochondria will allow further studies of these issues in cancer biology. ..
- Development of an instrument to track oxygen from blood to mitochondria in vivoKenneth A Schenkman; Fiscal Year: 2013..Our long-term goal is to develop the cell oximeter for clinical use in ambulances, emergency departments, intensive care units, and operating rooms. ..
- Quantum Chemistry of Proton Pumping by Cytochrome c OxidasesLouis Noodleman; Fiscal Year: 2013..Understanding the structures, mechanisms, and functions of mitochondrial CcO's is important for better analysis of many genetic and metabolic diseases and cancers, and is also relevant to pathologies of aging. ..
- 3-D CRYSTALLIZATION OF MEMBRANE PROTEINSJAMES GOUAUX; Fiscal Year: 1999..Extending the methods elucidated from this research to other systems will provide a structural understanding of such human conditions as cystic fibrosis, retinitis pigmentosa and multidrug resistance. ..
- CHORIOAMNIONITIS--CYTOKINES ALTER PERINATAL HEMODYNAMICSTOBY YANOWITZ; Fiscal Year: 2003..The varied and pertinent expertise of her committee members will make the development phase of her patient-oriented clinical research career a well-rounded and enlightening experience. ..
- MOLECULAR GENETICS OF BACILLUS SUBTILIS CYTOCHROME AA3Harry Taber; Fiscal Year: 1993....
- Biomimetic Studies of NO-binding Respiratory Chain HemesJAMES COLLMAN; Fiscal Year: 2008..An emphasis will be placed on kinetic and mechanistic studies to elucidate the putitive reaction pathways of CcO and NOR. ..
- Functional active-site models of cytochrome c oxidaseJAMES COLLMAN; Fiscal Year: 2009..The role that the copper ion (CuB) and a phenolic group, in the amino acid tyrosine (Tyr244) play in the catalytic function of CcO are of particular interest. ..
- Neurochemical Organization of Brain Stem Respiratory NucleiMARGARET TT WONG RILEY; Fiscal Year: 2010....
- Proton-coupled electron translocation in metalloenzymesROBERT CUKIER; Fiscal Year: 2006..Contemporaneously, we will explore PTR by simulation methodologies that we are developing, which combine quantum mechanics and molecular dynamics to quantitatively describe proton translocation. ..
- METABOLIC ORGANIZATION & REGULATION IN THE VISUAL CORTEXMargaret Wong Riley; Fiscal Year: 2002..Results from these studies are expected to provide insight into the molecular basis of metabolic responses of visual cortical neurons to changing functional demands. ..
- Cytochrome C Oxidase I:A Biomarker for Colon Cancer RiskClaire Payne; Fiscal Year: 2006..Various molecular and cellular techniques will be used in these studies. ..
- Catalytic Mechanisms of Heme-Copper OxidasesMarian Fabian; Fiscal Year: 2005..abstract_text> ..
- Role of Subunit III in Cytochrome Oxidase FunctionJonathan Hosler; Fiscal Year: 2007..unreadable] [unreadable]..
- Hypoxia-Inducible Factor 1 and Oxygen HomeostasisGregg Semenza; Fiscal Year: 2009....
- Mouse Models of Mitochondrial EncephalomyopathiesCARLOS MORAES; Fiscal Year: 2009..We expect these studies to provide evidence that specific defects in the OXPHOS can manifest as distinct phenotypic alterations. ..
- OXIDATIVE PHOSPHORYLATION IN CELL GROWTH AND DEATHCARLOS TORRES MORAES; Fiscal Year: 2010..abstract_text> ..
- Preventive of Bile Acid-Induced Colonic Oxidative DNA DamageClaire Margaret Payne; Fiscal Year: 2010..129 mice) developed in our laboratory;2) NOS-/- k.o./DOC mouse model;3) arginine-enhanced colon tumor ApcMin/+ mouse model developed in our laboratory;4) the AOM mouse model of colon carcinogenesis using A/J mice. ..
- Molecular mechanism of redox driven proton pumpsMarian Fabian; Fiscal Year: 2010..Specific aims will be addressed using the purified bovine heart oxidase, enzyme incorporated into phospholipid vesicles and in submitochondrial particles. ..
- EXPLORING NUCLEAR-MITOCHONDRIAL DNA INTERACTIONSCARLOS MORAES; Fiscal Year: 2004..We will also study some physical and biochemical properties of oocyte mitochondria and test if these specific features are optimized for mitochondrial maintenance in the egg. ..
- EXPRESSION OF HUMAN ERYTHROPOIETIN GENEGregg Semenza; Fiscal Year: 2002..abstract_text> ..
- PROTEIN TARGETS OF OXIDATIVE DAMAGE DURING AGINGRAJINDAR SOHAL; Fiscal Year: 2003..abstract_text> ..
- Influence of Diet on Mitochondria & Cardiolipin During Heart Failure in SHHF RatsGENEVIEVE SPARAGNA; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Transmission genetics of mammalian mitochondrial DNAEric Shoubridge; Fiscal Year: 2008..abstract_text> ..
- Old Westbury Neuroscience Research Institute MIDARPGeorge Stefano; Fiscal Year: 2008..abstract_text> ..
- Modulation of ATP synthesis in mitochondrial disordersGiovanni Manfredi; Fiscal Year: 2008....
- Cortical Representational Plasticity of Oral StructuresKENNETH CATANIA; Fiscal Year: 2003..abstract_text> ..
- Effect of Age on Exercise-Induced CardioprotectionJOSEPH STARNES; Fiscal Year: 2003..The results of this Aim will provide key direction for the effective design of further comprehensive studies using inhibitors and/or activators of specific proteins or signaling pathways. ..
- Chronic Alcohol and Liver Oxidative StressShannon Bailey; Fiscal Year: 2003..This investigation should thus provide information on ethanol-elicited alterations that contribute to oxidative damage in the liver. ..
- Mitochondrial Function and Aging in S. cerevisiaePAUL KIRCHMAN; Fiscal Year: 2003..Results from these experiments will serve to clarify the role of variations in mitochondrial function in determining longevity. ..
- Cytochrome Oxidase Polymorphisms in AgingRussell Swerdlow; Fiscal Year: 2007..This work could help explain why complex genetic diseases are sometimes associated with mitochondrial dysfunction. ..
- In Vivo EPR Imaging of Myocardial Oxygen ConsumptionGuanglong He; Fiscal Year: 2009..Critical information will be obtained regarding the regulatory role of endothelium-derived NO on myocardial oxygen consumption, redox alterations, and postichemic myocardial injury and protection in cardiac physiology and disease. ..
- BIOENERGETIC MECHANISMS IN MULTICENTER ENZYMESShelagh Ferguson Miller; Fiscal Year: 2002..For sGC, we will study the molecular mechanisms that allow efficient NO/O2 discrimination and begin work aimed at understanding how NO binding triggers cyclase activity. ..
- MOLECULAR GENETICS OF MAMMALIAN CYTOCHROME C OXIDASELawrence Grossman; Fiscal Year: 2001....
- Somatosensory Cortical Influences on Subcortical ProcessingKEVIN DOUGLAS ALLOWAY; Fiscal Year: 2010....
- Oral Yeast Carriage and Salivary Antifungal ActivityEVA HELMERHORST; Fiscal Year: 2008..The experiments outlined here will provide the basis for a better understanding of antifungal mechanisms exerted by saliva in the oral cavity. [unreadable] [unreadable] [unreadable]..
- INDUCTION AND BIOGENESIS OF SUBCELLULAR ORGANELLESSamuel Kaplan; Fiscal Year: 2008..It is likely, that these studies will serve as a guide to the potential role of the electron transport chain in gene regulation in higher organisms. ..
- IGF-1 in neocortical development and plasticityDavid Riddle; Fiscal Year: 2006..unreadable] [unreadable]..
- IGF-1 Receptor Signaling in Mammary Gland DevelopmentDarryl Hadsell; Fiscal Year: 2006..abstract_text> ..
- Oxidants, Mitochondria,and Renal Ischemia/ReperfusionLEE MACMILLAN CROW; Fiscal Year: 2005..This information will be helpful in determining possible therapeutic interventions for improving current techniques in renal preservation and transplantation. ..
- IRON DEFICIENCY AND DOPAMINEJohn Beard; Fiscal Year: 2004..This expansion of study to other neurotransmitters will significantly contribute to our knowledge of the effects of iron deficiency on brain functioning in early life. ..
- ANTIESTROGEN-RECEPTOR INTERACTION WITH DNARussell Hilf; Fiscal Year: 2005..Overall, the plan is to determine how the ERa and ERb subtypes interact with natural EREs, various ligands, and with each other to regulate gene expression." ..
- Pathogenesis of a Novel Limb-Girdle Muscular DystrophyMichio Hirano; Fiscal Year: 2003..For the patients, achieving the proposed goals will allow more accurate prenatal diagnosis, genetic counseling, and perhaps contribute to more rational therapies in the future. ..
- Improving Bayesian PhylogenyBret Larget; Fiscal Year: 2006..abstract_text> ..
- Attentional Regulation of Plasticity in Auditory CortexDaniel Polley; Fiscal Year: 2004..abstract_text> ..
- DESIGN, SYNTHESIS AND STUDY OF NEW SENSITIZERS FOR PDTMICHAEL DETTY; Fiscal Year: 2004....
- Functional organization of auditory corticothalamic projection systemsDaniel Llano; Fiscal Year: 2007..It is hoped that this work will lead to a better understanding of speech perception and to new ways to diagnose and treat patients who have lost their ability to use language. [unreadable] [unreadable] [unreadable]..
- Development and Improvement of an Animal Resource CoreDale Bredesen; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Population genetic structure and bionomics of Anopheles lesteri in ChinaYajun Ma; Fiscal Year: 2007..lesteri mosquitoes as well as the geographic variation of its bionomics. This information is particularly useful for the design of rational area-specific vector control methods. [unreadable] [unreadable]..
- Modulation of age-related changes in the auditory systemJAMES WILLOTT; Fiscal Year: 2008..The ultimate goal is to develop new approaches for amelioration and treatment ofpresbycusis and other hearing disorders. [unreadable] [unreadable]..
- Center for Integrative Studies of AgingDale Bredesen; Fiscal Year: 2004....
- Lung Metabolism: Multiple Indicator DilutionSaid H Audi; Fiscal Year: 2010..Such results will provide targets for future mechanistic studies designed to evaluate the utility of the differentially altered redox enzymes as potential therapeutic targets for protection from O2 toxicity. ..
- Genetic analysis of Htr2c RNA editing in amygdalaDAVID AIREY; Fiscal Year: 2008..The brain region of investigation is the amygdala, which is rich in serotonin 2C receptors and plays important roles in anxiety disorders and depression. [unreadable] [unreadable]..
- Functional Organization of Somatosensory CortexKEVIN ALLOWAY; Fiscal Year: 2007..To address this issue, conditional cross-correlation analysis will be used to quantify the impact of synchronized activity in SI on the probability of neuronal responsiveness in corresponding parts of the MI whisker representation. ..
- PINEAL OPIOID RECEPTORS & ANALGESIC ACTION OF MELATONINManuchair Ebadi; Fiscal Year: 2002..Therefore, future research must synthesize highly efficacious melatonin analogues capable of providing maximum analgesia and hopefully being devoid of addiction liability now associated with currently available narcotics. ..
- The organization and plasticity of cortical areas representing the dentitionKENNETH CATANIA; Fiscal Year: 2009..The long-term goal of these experiments is to identify general principles of brain organization and plasticity. ..