serum amyloid p component

Summary

Summary: Amyloid P component is a small, non-fibrillar glycoprotein found in normal serum and in all amyloid deposits. It has a pentagonal (pentaxin) structure. It is an acute phase protein, modulates immunologic responses, inhibits ELASTASE, and has been suggested as an indicator of LIVER DISEASE.

Top Publications

  1. ncbi Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility
    Cecilia Garlanda
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    Annu Rev Immunol 23:337-66. 2005
  2. ncbi Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction
    Roberto Latini
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Circulation 110:2349-54. 2004
  3. ncbi Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
    Cecilia Garlanda
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    Nature 420:182-6. 2002
  4. ncbi Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component
    F Breviario
    Istituto Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Biol Chem 267:22190-7. 1992
  5. ncbi TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins
    G W Lee
    Department of Microbiology, New York University Medical Center, NY 10016
    J Immunol 150:1804-12. 1993
  6. ncbi Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes
    V V Alles
    Laboratory of Immunology, Istituto di Ricerche Farmacologiche, Mario Negri, Milano, Italy
    Blood 84:3483-93. 1994
  7. ncbi PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization
    Antonietta Salustri
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome 00133, Italy
    Development 131:1577-86. 2004
  8. ncbi Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activation
    Antonio Inforzato
    Department of Biology, University Tor Vergata, Rome, Italy
    Biochemistry 45:11540-51. 2006
  9. ncbi Biochemical and functional characterization of the interaction between pentraxin 3 and C1q
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:465-73. 2003
  10. ncbi Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells
    Andrea Doni
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur J Immunol 33:2886-93. 2003

Detail Information

Publications212 found, 100 shown here

  1. ncbi Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility
    Cecilia Garlanda
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    Annu Rev Immunol 23:337-66. 2005
    C reactive protein, the first innate immunity receptor identified, and serum amyloid P component are classic short pentraxins produced in the liver. Long pentraxins, including the prototype PTX3, are expressed in a variety of tissues...
  2. ncbi Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction
    Roberto Latini
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Circulation 110:2349-54. 2004
    ..The aim of this study was to assess the prognostic value of PTX3 in MI compared with the best-known and clinically relevant biological markers...
  3. ncbi Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
    Cecilia Garlanda
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    Nature 420:182-6. 2002
    ..The classical short pentraxins, C-reactive protein (CRP) and serum amyloid P component (SAP), are acute-phase proteins produced in the liver in response to inflammatory mediators...
  4. ncbi Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component
    F Breviario
    Istituto Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Biol Chem 267:22190-7. 1992
    ..beta) has led to the identification of a novel gene (PTX3) related to pentaxins (C-reactive protein and serum amyloid P component in man), a subclass of acute phase proteins...
  5. ncbi TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins
    G W Lee
    Department of Microbiology, New York University Medical Center, NY 10016
    J Immunol 150:1804-12. 1993
    ..Our data strongly suggest that TSG-14 is a novel member of the pentaxin family of acute phase proteins...
  6. ncbi Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes
    V V Alles
    Laboratory of Immunology, Istituto di Ricerche Farmacologiche, Mario Negri, Milano, Italy
    Blood 84:3483-93. 1994
    The pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP) are acute-phase proteins produced by liver epithelial cells...
  7. ncbi PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization
    Antonietta Salustri
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome 00133, Italy
    Development 131:1577-86. 2004
    ..Thus, PTX3 is a structural constituent of the cumulus oophorus extracellular matrix essential for female fertility...
  8. ncbi Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activation
    Antonio Inforzato
    Department of Biology, University Tor Vergata, Rome, Italy
    Biochemistry 45:11540-51. 2006
    ..In conclusion, our results provided evidence of an involvement of the PTX3 sugar moiety in C1q recognition and complement activation...
  9. ncbi Biochemical and functional characterization of the interaction between pentraxin 3 and C1q
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:465-73. 2003
    ..Classical short pentraxins, C-reactive protein, and serum amyloid P component can bind to C1q and thereby activate the classical complement pathway...
  10. ncbi Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells
    Andrea Doni
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur J Immunol 33:2886-93. 2003
    ..coupled to a C-terminal pentraxin domain, the latter related to short pentraxins (C-reactive protein and serum amyloid P component)...
  11. ncbi Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3
    Alberto Mantovani
    Istituto Clinico Humanitas, Via Manzoni 56, 20089, Milan, Rozzano, Italy
    J Clin Immunol 28:1-13. 2008
    ..Evidence suggests that PTX3 is a useful new serological marker, rapidly reflecting tissue inflammation and damage under diverse clinical conditions...
  12. ncbi PTX3 interacts with inter-alpha-trypsin inhibitor: implications for hyaluronan organization and cumulus oophorus expansion
    Laura Scarchilli
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, 00133 Rome
    J Biol Chem 282:30161-70. 2007
    ....
  13. ncbi PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages
    S N Diniz
    Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    J Leukoc Biol 75:649-56. 2004
    ..Our results provide evidence for a role of PTX3 as an important component of the innate-immune response and as part of the host mechanisms that control fungal recognition and phagocytosis...
  14. ncbi The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells, and edits the cross-presentation of self, viral, and tumor antigens
    Paramita Baruah
    Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Institute, Milan, Italy
    Blood 107:151-8. 2006
    ..These data suggest that PTX3 acts as a third-party agent between microbial stimuli and dying cells, contributing to limit tissue damage under inflammatory conditions and the activation of autoreactive T cells...
  15. ncbi Binding of the long pentraxin PTX3 to factor H: interacting domains and function in the regulation of complement activation
    Livija Deban
    Laboratory for Immunology and Inflammation, Instituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, Rozzano, Italy
    J Immunol 181:8433-40. 2008
    ..Thus, our findings identify PTX3 as a unique FH ligand in that it can bind both of the two hot-spots of FH, namely SCR7 and SCR19-20 and indicate that PTX3 participates in the localization of functionally active FH...
  16. doi Determination of physiological plasma pentraxin 3 (PTX3) levels in healthy populations
    Kazumi Yamasaki
    Narao Hospital, Nagasaki, Japan
    Clin Chem Lab Med 47:471-7. 2009
    ..The aim of this study was to evaluate the distribution of pentraxin 3 (PTX3) values in healthy subjects and to characterize its relationship with gender, age, body mass index (BMI), lipid profile, and blood sugar levels...
  17. ncbi Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility
    Simona Varani
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 16:1154-67. 2002
    ..These studies demonstrate that PTX3 plays important roles in cumulus cell-oocyte interaction in the periovulatory period as a downstream protein in the GDF-9 signal transduction cascade...
  18. ncbi Promoter structure and transcriptional activation of the murine TSG-14 gene encoding a tumor necrosis factor/interleukin-1-inducible pentraxin protein
    A Altmeyer
    Department of Microbiology, New York University Medical Center, New York 10016, USA
    J Biol Chem 270:25584-90. 1995
    ..to proteins of the pentraxin family, which includes the acute phase reactants C-reactive protein and serum amyloid P component. Levels of TSG-14 protein (also termed PTX-3) become elevated in the serum of mice and humans after ..
  19. doi Pentraxin 3 in acute respiratory distress syndrome: an early marker of severity
    Tommaso Mauri
    General Intensive Care Unit, Department of Perioperative Medicine and Intensive Care, San Gerardo Hospital, Monza, Milano, Italy
    Crit Care Med 36:2302-8. 2008
    ..We investigated the role of pentraxin 3 as a marker of severity and outcome predictor of acute lung injury and acute respiratory distress syndrome...
  20. ncbi Establishment of a high sensitivity plasma assay for human pentraxin3 as a marker for unstable angina pectoris
    Kenji Inoue
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4 6 1, Komaba, Meguro, Tokyo, 153 8904, Japan
    Arterioscler Thromb Vasc Biol 27:161-7. 2007
    ..To critically evaluate the role of PTX3 in UAP, a sensitive and precise measurement of PTX3 concentration is needed...
  21. ncbi The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility
    Barbara Bottazzi
    Istituto Clinico Humanitas, Rozzano, Milan, Italy
    J Leukoc Biol 79:909-12. 2006
    ..Thus, the prototypic long pentraxin PTX3 is a multifunctional, soluble pattern recognition receptor acting as a nonredundant component of the humoral arm of innate immunity and involved in matrix deposition and female fertility...
  22. pmc Influenza virus infection is not affected by serum amyloid P component
    Jeff Herbert
    Department of Medicine, Royal Free and University College Medical School, London, UK
    Mol Med 8:9-15. 2002
    Binding of serum amyloid P component (SAP) to its ligands, including bacteria, chromatin and amyloid fibrils, protects them from degradation, is anti-opsonic and anti-immunogenic...
  23. ncbi PTX3 in small-vessel vasculitides: an independent indicator of disease activity produced at sites of inflammation
    F Fazzini
    Istituto Scientifico H San Raffaele and Università, Milan, Italy
    Arthritis Rheum 44:2841-50. 2001
    ..To verify whether the prototypical long pentraxin PTX3 represents an indicator of the activity of small-vessel vasculitis...
  24. ncbi Serum amyloid P component and C-reactive protein mediate phagocytosis through murine Fc gamma Rs
    C Mold
    Department of Molecular Genetics and Microbiology, Veterans Affairs Medical Center, and Department of Medicine, University of New Mexico, Albuquerque, NM 87131, USA
    J Immunol 166:1200-5. 2001
    The pentraxins, serum amyloid P component (SAP) and C-reactive protein (CRP) are acute-phase serum proteins in mice and humans, respectively...
  25. ncbi Structure of pentameric human serum amyloid P component
    J Emsley
    Laboratory of Molecular Biology, Birkbeck College, London, UK
    Nature 367:338-45. 1994
    The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins...
  26. ncbi Serum amyloid P component inhibits influenza A virus infections: in vitro and in vivo studies
    A Horvath
    Department of Immunology, L Eotvos University, God, Hungary
    Antiviral Res 52:43-53. 2001
    b>Serum amyloid P component (SAP) binds in vitro Ca(2+)-dependently to several ligands including oligosaccharides with terminal mannose and galactose...
  27. ncbi Serum amyloid P component and C-reactive protein opsonize apoptotic cells for phagocytosis through Fcgamma receptors
    Carolyn Mold
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87108, USA
    J Autoimmun 19:147-54. 2002
    b>Serum amyloid P component (SAP) and C-reactive protein (CRP) are opsonins that react with nuclear autoantigens targeted in systemic autoimmunity...
  28. pmc Expression of a long pentraxin, PTX3, by monocytes exposed to the mycobacterial cell wall component lipoarabinomannan
    V Vouret-Craviari
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Infect Immun 65:1345-50. 1997
    ..The significance of PTX3 in the immunobiology of mycobacterial infection and its relevance in relation to clinical involvement remain to be determined...
  29. ncbi Pentraxin3 is a novel marker for stent-induced inflammation and neointimal thickening
    Norihiko Kotooka
    Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, Saga, Japan
    Atherosclerosis 197:368-74. 2008
    ..547, P=0.007). Coronary stenting enhanced circulating PTX3 levels in association with an inflammatory response. PTX3 may be a useful marker for evaluation of inflammatory reaction and neointimal thickening after vascular injury...
  30. pmc Lipopolysaccharide (LPS)-binding synthetic peptides derived from serum amyloid P component neutralize LPS
    C J de Haas
    Department of Inflammation, Eijkman Winkler Institute, University Utrecht, The Netherlands
    Infect Immun 67:2790-6. 1999
    ..We showed that serum amyloid P component (SAP) neutralizes LPS...
  31. ncbi Complement dependent amplification of the innate response to a cognate microbial ligand by the long pentraxin PTX3
    Alessia Cotena
    Istituto Clinico Humanitas, Rozzano Milan, Italy
    J Immunol 179:6311-7. 2007
    ..The results reported here demonstrate that PTX3 activates a complement-dependent humoral amplification loop of the innate response to a microbial ligand...
  32. ncbi Regulation of PTX3, a key component of humoral innate immunity in human dendritic cells: stimulation by IL-10 and inhibition by IFN-gamma
    Andrea Doni
    Istituto Clinico Humanitas ICH, Via Manzoni, 56 20089 Rozzano, Milan, Italy
    J Leukoc Biol 79:797-802. 2006
    ..As PTX3 is also an extracellular matrix component, IL-10-enhanced PTX3 production may play a role in orchestration of tissue remodeling in chronic inflammation...
  33. pmc Role of serum amyloid P component in bacterial infection: protection of the host or protection of the pathogen
    M Noursadeghi
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London NW3 2PF, United Kingdom
    Proc Natl Acad Sci U S A 97:14584-9. 2000
    b>Serum amyloid P component (SAP) binds to Streptococcus pyogenes, and we show here that it also binds to Neisseria meningitidis, including a lipopolysaccharide (LPS)-negative mutant, and to rough variants of Escherichia coli...
  34. pmc Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure
    M B Pepys
    Immunological Medicine Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    Proc Natl Acad Sci U S A 91:5602-6. 1994
    Human serum amyloid P component (SAP) is a normal plasma protein and the precursor of amyloid P component (AP), a universal constituent of the abnormal tissue deposits in amyloidosis, including Alzheimer disease...
  35. ncbi Serum amyloid P component binds to late apoptotic cells and mediates their uptake by monocyte-derived macrophages
    Marc Bijl
    Department of Internal Medicine, University Hospital, Groningen, The Netherlands
    Arthritis Rheum 48:248-54. 2003
    ..We undertook this study to determine whether serum amyloid P component (SAP; a pentraxin that, when deficient in mice, results in lupus-like disease) binds to apoptotic cells ..
  36. pmc Human serum amyloid P component is a single uncomplexed pentamer in whole serum
    W L Hutchinson
    Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Mol Med 6:482-93. 2000
    b>Serum amyloid P component (SAP) is a universal constituent of amyloid deposits and contributes to their pathogenesis. SAP also has important normal functions in the handling of chromatin in vivo and resistance to bacterial infection...
  37. ncbi Characterization of genomic and complementary DNA sequence of human C-reactive protein, and comparison with the complementary DNA sequence of serum amyloid P component
    P Woo
    J Biol Chem 260:13384-8. 1985
    ..A comparison of CRP coding and amino acid sequences with those of serum amyloid P component revealed striking overall homology which was not uniform: a region of limited conservation is bounded by ..
  38. pmc Serum amyloid P component prevents high-density lipoprotein-mediated neutralization of lipopolysaccharide
    C J de Haas
    Department of Inflammation, Eijkman Winkler Institute, University Medical Center, 3584CX Utrecht, The Netherlands
    Infect Immun 68:4954-60. 2000
    ..Recently, serum amyloid P component (SAP) was shown to neutralize LPS in vitro, although only in the presence of low concentrations of LBP...
  39. pmc Serum amyloid P component levels are not decreased in patients with systemic lupus erythematosus and do not rise during an acute phase reaction
    M Bijl
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital, PO Box 30 001, 9700 RB Groningen, Netherlands
    Ann Rheum Dis 63:831-5. 2004
    b>Serum amyloid P component (SAP) and acute phase proteins like C-reactive protein contribute to the clearance of apoptotic cells. This response is diminished in systemic lupus erythematosus (SLE).
  40. ncbi The structures of crystalline complexes of human serum amyloid P component with its carbohydrate ligand, the cyclic pyruvate acetal of galactose
    D Thompson
    School of Biological Science, University of Southampton, Bassett Crescent East, Hampshire, UK
    J Mol Biol 320:1081-6. 2002
    Two monoclinic (P2(1)) crystal forms of human serum amyloid P component (SAP) in complex with the 4,6-pyruvate acetal of beta-D-galactose (MObetaDG) were prepared. Structure analysis by molecular replacement and refinement at 2...
  41. ncbi Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins
    G W Lee
    Department of Microbiology, New York University Medical Center, NY 10016
    J Immunol 153:3700-7. 1994
    ..encodes a secreted glycoprotein with significant sequence homology to C-reactive protein (CRP) and serum amyloid P component (SAP), members of the pentraxin family of acute phase proteins...
  42. ncbi Diagnostic performance and prognostic value of extravascular retention of 123I-labeled serum amyloid P component in systemic amyloidosis
    Bouke P C Hazenberg
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Nucl Med 48:865-72. 2007
    b>Serum amyloid P component (SAP) binds to amyloid. (123)I-SAP scintigraphy is used to evaluate the extent and distribution of amyloid in systemic amyloidosis and has great clinical value in the detection of systemic amyloidosis...
  43. ncbi Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component
    B Bottazzi
    From the Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    J Biol Chem 272:32817-23. 1997
    ..binding properties of human PTX3, in comparison with the classical pentraxins C-reactive protein and serum amyloid P component. Sequencing of Chinese hamster ovary cell-expressed PTX3 revealed that the mature secreted protein ..
  44. ncbi A pentameric form of human serum amyloid P component. Crystallization, X-ray diffraction and neutron scattering studies
    S P Wood
    Department of Crystallography, Birkbeck College, London, U K
    J Mol Biol 202:169-73. 1988
    Human serum amyloid P component crystallizes from sodium acetate buffer (pH 5.5) in the presence of calcium and polyethylene glycol 6000, at 4 degrees C. The space group is P2(1) and the cell parameters are a = 69.0 A (1 A = 0...
  45. ncbi Preferential association of serum amyloid P component with fibrillar deposits in familial British and Danish dementias: similarities with Alzheimer's disease
    Agueda Rostagno
    Department of Pathology, New York University School of Medicine, New York 10016, USA
    J Neurol Sci 257:88-96. 2007
    ....
  46. ncbi Molecular chaperone properties of serum amyloid P component
    A R Coker
    Division of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, UK
    FEBS Lett 473:199-202. 2000
    The selective binding of serum amyloid P component (SAP) to proteins in the pathological amyloid cross-beta fold suggests a possible chaperone role...
  47. doi Sustained pharmacological depletion of serum amyloid P component in patients with systemic amyloidosis
    Julian D Gillmore
    Centre for Amyloidosis and Acute Phase Proteins and the National Amyloidosis Centre, University College London Medical School, London, UK
    Br J Haematol 148:760-7. 2010
    b>Serum amyloid P component (SAP) is a universal constituent of amyloid deposits and contributes to their formation and/or persistence...
  48. ncbi Serum amyloid P component-DNA complexes are decreased in systemic lupus erythematosus. inverse association with anti-dsDNA antibodies
    Anne Voss
    Department of Rheumatology, Odense University Hospital, Odense, Denmark
    J Rheumatol 35:625-30. 2008
    To study serum levels of serum amyloid P component (SAP) and SAP-DNA complexes in a population-based cohort of patients with systemic lupus erythematosus (SLE).
  49. ncbi Elevated plasma levels of the long pentraxin, pentraxin 3, in severe dengue virus infections
    Albert T A Mairuhu
    Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
    J Med Virol 76:547-52. 2005
    ..The role of pentraxin 3 in the pathogenesis of dengue and its potential as an early prognostic indicator of disease severity needs further assessment...
  50. ncbi Circulating levels of the long pentraxin PTX3 correlate with severity of infection in critically ill patients
    B Muller
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Crit Care Med 29:1404-7. 2001
    ..Compared with the short pentraxin C-reactive protein, PTX3 may be a more direct indicator of tissue involvement by inflammatory and infectious processes...
  51. ncbi Human serum amyloid P component protects against Escherichia coli O157:H7 Shiga toxin 2 in vivo: therapeutic implications for hemolytic-uremic syndrome
    Glen D Armstrong
    Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Canada
    J Infect Dis 193:1120-4. 2006
    ..Here, we show that serum amyloid P component (SAP), a normal human plasma protein, specifically protects mice against the lethal toxicity of Stx2, ..
  52. ncbi Serum amyloid P component scintigraphy for diagnosis and monitoring amyloidosis
    Philip N Hawkins
    Department of Medicine, Royal Free and University College Medical School London, UK
    Curr Opin Nephrol Hypertens 11:649-55. 2002
    b>Serum amyloid P component is a normal plasma protein and a universal non-fibrillar constituent of amyloid deposits...
  53. ncbi Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3
    Maura Camozzi
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, 25123 Brescia, Italy
    J Biol Chem 281:22605-13. 2006
    ....
  54. ncbi Interferon-gamma inhibits expression of the long pentraxin PTX3 in human monocytes
    N Polentarutti
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur J Immunol 28:496-501. 1998
    ..PTX3 protein secretion by activated monocytes is also suppressed by exposure to IFN-gamma. Altogether, these data identify a negative pathway of regulation mediated by IFN-gamma, which may occur under inflammatory conditions...
  55. doi Pentraxin 3 and C-reactive protein in severe meningococcal disease
    Tom Sprong
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Shock 31:28-32. 2009
    ..In conclusion, PTX3 was an early indicator of shock in patients with severe meningococcal disease that followed a pattern of induction distinct from CRP...
  56. ncbi The physiological structure of human C-reactive protein and its complex with phosphocholine
    D Thompson
    School of Biological Sciences, University of Southampton, Southampton SO16 7PX UK
    Structure 7:169-77. 1999
    ..CRP may also have pathogenic effects and the recent discovery of a prognostic association between increased CRP production and coronary atherothrombotic events is of particular interest...
  57. ncbi Production of the long pentraxin PTX3 in advanced atherosclerotic plaques
    Michael S Rolph
    Heart Research Institute, Camperdown, New South Wales, Australia
    Arterioscler Thromb Vasc Biol 22:e10-4. 2002
    ..Infrequent expression by smooth muscle cells was also observed. Our results suggest that PTX3 may contribute to the pathogenesis of atherosclerosis...
  58. ncbi Involvement of CD14 and toll-like receptor 4 in the acute phase response of serum amyloid A proteins and serum amyloid P component in the liver after burn injury
    Kiho Cho
    Burn Research, Shriners Hospitals for Children Northern California, Department of Surgery, University of California at Davis, Sacramento 95817, USA
    Shock 21:144-50. 2004
    Acute phase proteins such as serum amyloid A proteins (SAAs) and serum amyloid P component (SAP) are induced in the liver after various insults (e.g., infection, injury)...
  59. ncbi Elevated maternal levels of the long pentraxin 3 (PTX3) in preeclampsia and intrauterine growth restriction
    Irene Cetin
    Institute of Obstetrics and Gynecology, Fondazione IRCCS Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Am J Obstet Gynecol 194:1347-53. 2006
    ..We investigated pentraxin 3 levels in preeclampsia and intrauterine growth restriction, pregnancy conditions related to altered placentation...
  60. ncbi Serum amyloid P-component in murine tuberculosis: induction kinetics and intramacrophage Mycobacterium tuberculosis growth inhibition in vitro
    Prati Pal Singh
    National Institute of Pharmaceutical Education and Research, Phase X, SAS Nagar 160 062, India
    Microbes Infect 8:541-51. 2006
    ..tuberculosis growth, in vitro, apparently via NO-dependent mechanism(s). SAP may thus contribute both to the pathogenesis and pulmonary innate immunity in TB...
  61. ncbi The long pentraxin PTX3 in human endometrium: regulation by steroids and trophoblast products
    Roxana M Popovici
    Department of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, Voss Strasse 9, 69115 Heidelberg, Germany
    Endocrinology 149:1136-43. 2008
    ..Also, of the factors secreted by trophoblast, IL-1beta induces PTX3 in human endometrial stromal cells...
  62. ncbi Pentraxin 3, a new marker for vascular inflammation, predicts adverse clinical outcomes in patients with heart failure
    Satoshi Suzuki
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Am Heart J 155:75-81. 2008
    ..The purpose of the present study was to examine the clinical significance of plasma PTX3 levels in patients with heart failure...
  63. ncbi The pentraxin serum amyloid P component is found in the male genital tract and attached to spermatozoa
    Johan Malm
    Division of Clinical Chemistry, Department of Laboratory Medicine, Lund University, University Hospital MAS, Malmo, Sweden
    Int J Androl 31:508-17. 2008
    b>Serum amyloid P component (SAP) belongs to the pentraxin family of proteins, members of which are characterized by radial pentameric structure and calcium-dependent ligand binding...
  64. ncbi C-reactive protein and cardiovascular disease: new insights from an old molecule
    G M Hirschfield
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, Royal Free Campus, London, UK
    QJM 96:793-807. 2003
    ..We review the biological properties of CRP, the association between CRP and cardiovascular disease, and the possibility that CRP may be a novel therapeutic target...
  65. ncbi The long pentraxin 3 in cardiac surgery: distinct responses in "on-pump" and "off-pump" patients
    Pavel Kunes
    Department of Cardiac Surgery, Charles University in Prague, University Hospital and Faculty of Medicine in Hradec Králové, Czech Republic
    Scand Cardiovasc J 41:171-9. 2007
    ..The purpose of this study was to assess the kinetics of release of PTX3 in cardiac surgical patients, operated on either with or without the use of cardiopulmonary bypass (CPB)...
  66. doi Expression of pentraxin 3 (PTX3) in human atherosclerotic lesions
    As Savchenko
    Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Pathol 215:48-55. 2008
    ..Interestingly, we also clearly observed PTX3-positive neutrophils infiltrating into atherosclerotic plaques, suggesting that PTX3 derived from neutrophils as well as macrophages plays an important role in atherogenesis...
  67. ncbi Serum amyloid P and cardiovascular disease in older men and women: results from the Cardiovascular Health Study
    Nancy Swords Jenny
    Department of Pathology, College of Medicine, University of Vermont, 208 South Park Drive, Suite 2, Colchester, VT 05446, USA
    Arterioscler Thromb Vasc Biol 27:352-8. 2007
    ..Serum amyloid P (SAP), a pentraxin like C-reactive protein (CRP), functions in innate immunity. However, associations of SAP with cardiovascular disease (CVD) are unknown...
  68. ncbi Binding of Ca2+, Mg2+, and heparin by human serum amyloid P component in affinity capillary electrophoresis
    Niels H H Heegaard
    Department of Autoimmunology, Statens Serum Institut, Copenhagen S, Denmark
    Electrophoresis 27:2609-15. 2006
    Human serum amyloid P component (SAP) is a glycoprotein circulating in the blood and found in association with all types of amyloid (malfolded potein aggregates) examined so far...
  69. ncbi High-volume ventilation induces pentraxin 3 expression in multiple acute lung injury models in rats
    Daisuke Okutani
    Thoracic Surgery Research Laboratory, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    Am J Physiol Lung Cell Mol Physiol 292:L144-53. 2007
    ..A local expression of PTX3 induced by high-volume ventilation, either alone or in combination with other pathological conditions, suggests that it may be an important mediator in ventilator-induced lung injury...
  70. ncbi TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK
    Bing Han
    Thoracic Surgery Research Laboratory, University Health Network Toronto General Research Institute, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Immunol 175:8303-11. 2005
    ..The importance of the JNK pathway for the regulated PTX3 expression may be a potential target for its regulation in the lung...
  71. ncbi Protective molecules--C-reactive protein (CRP), serum amyloid P (SAP), pentraxin3 (PTX3), mannose-binding lectin (MBL), and apolipoprotein A1 (Apo A1), and their autoantibodies: prevalence and clinical significance in autoimmunity
    Martine Szyper Kravitz
    Center for Autoimmune Diseases and Department of Medicine B, Chaim Sheba Medical Center Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Clin Immunol 25:582-91. 2005
    ....
  72. ncbi Glycosaminoglycans inhibit neurodegenerative effects of serum amyloid P component in vitro
    Zoltán Urbányi
    Laboratory of Molecular Neurobiological Research, Gedeon Richter Ltd, PO Box 27, H 1475 Budapest 10, Hungary
    Neurochem Int 46:471-7. 2005
    b>Serum amyloid P component, a member of pentraxin serum protein family, has been suggested to contribute to the progression of neurodegeneration including Alzheimer's disease by binding to beta-amyloid fibrils leading to an increased ..
  73. ncbi Serum amyloid P component in mink, a non-glycosylated protein with affinity for phosphorylethanolamine and phosphorylcholine
    Lone A Omtvedt
    Department of Rheumatology Institute of Immunology, Rikshospitalet, University of Oslo, Blindern, Norway
    Amyloid 11:101-8. 2004
    ..In the present work, we have characterized the serum amyloid P component (SAP) in mink...
  74. ncbi Proteomic analysis of UVC irradiation-induced damage of plasma proteins: Serum amyloid P component as a major target of photolysis
    Hong Lin Chan
    Ludwig Institute for Cancer Research and Department of Biochemistry and Molecular Biology, University College London, Cruciform Building, Gower Street, London WC1E 6BT, UK
    FEBS Lett 580:3229-36. 2006
    ..We identify a number of the damaged proteins by mass spectrometry, including serum amyloid P component, and further demonstrate UVC-induced photolysis of its disulphide bond.
  75. ncbi Proteomic characterization of novel serum amyloid P component variants from human plasma and urine
    Urban A Kiernan
    Intrinsic Bioprobes Inc, Tempe, AZ 85281, USA
    Proteomics 4:1825-9. 2004
    b>Serum amyloid P component (SAP) is a human plasma protein that has been widely studied for its influence on amyloid plaque formation and stabilization...
  76. ncbi Serum amyloid P-component-mediated inhibition of the uptake of Mycobacterium tuberculosis by macrophages, in vitro
    S Kaur
    National Institute of Pharmaceutical Education and Research, S A S Nagar, Punjab, India
    Scand J Immunol 59:425-31. 2004
    ..tuberculosis Erdman by mouse AMs, which was also associated with their reduced intracellular growth...
  77. pmc Serum amyloid P component binding to Shiga toxin 2 requires both a subunit and B pentamer
    Paola Marcato
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Infect Immun 71:6075-8. 2003
    ..A polyvalent globotriaosyl-ceramide receptor analog, Daisy, did not competitively inhibit HuSAP binding, implying that the two ligands bind to different Stx2 domains...
  78. ncbi Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene
    M Botto
    Rheumatology Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Nat Med 3:855-9. 1997
    ..amyloidosis, Alzheimer's disease and the transmissible spongiform encephalopathies always contain serum amyloid P component (SAP) bound to the amyloid fibrils...
  79. pmc Increased mortality and inflammation in tumor necrosis factor-stimulated gene-14 transgenic mice after ischemia and reperfusion injury
    Danielle G Souza
    Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Am J Pathol 160:1755-65. 2002
    ..Taken together, our data point to a critical role of TSG-14 in controlling acute inflammatory response in part via the modulation of TNF-alpha expression...
  80. ncbi Chromatin-independent binding of serum amyloid P component to apoptotic cells
    A Familian
    CLB, Sanquin Blood Supply Foundation and Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 167:647-54. 2001
    Human serum amyloid P component (SAP) is a glycoprotein structurally belonging to the pentraxin family of proteins, which has a characteristic pentameric organization...
  81. ncbi Mice lacking serum amyloid P component do not necessarily develop severe autoimmune disease
    M Soma
    First Department of Biochemistry, Yamanashi Medical University, 1110 Shimokato, Tamaho cho, Nakakoma gun, Yamanashi 409 3898, Japan
    Biochem Biophys Res Commun 286:200-5. 2001
    b>Serum amyloid P component (SAP) is a major acute-phase reactant in mice. Recently, it was reported that SAP-deficient mice spontaneously developed anti-nuclear antibodies and severe glomerulonephritis...
  82. ncbi Human serum amyloid P component oligomers bind and activate the classical complement pathway via residues 14-26 and 76-92 of the A chain collagen-like region of C1q
    S C Ying
    Department of Immunology Microbiology, Rush Medical College, Chicago, IL 60612
    J Immunol 150:169-76. 1993
    b>Serum amyloid P component (SAP) was polymerized using the cleavable cross-linker 3,3'-dithio-bis-(sulfo-succinimidylpropionate) to study its interaction with the C system...
  83. ncbi Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites
    M Introna
    Istituto di Recerche Farmacologiche Mario Negri, Milano, Italy
    Blood 87:1862-72. 1996
    Pentraxins, which include C reactive protein (CRP) and serum amyloid P component (SAP), are prototypic acute phase reactants that serve as indicators of inflammatory reactions...
  84. ncbi PTX3, A prototypical long pentraxin, is an early indicator of acute myocardial infarction in humans
    G Peri
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Circulation 102:636-41. 2000
    ..The possibility that PTX3 is altered in patients with acute myocardial infarction (AMI) has not yet been tested...
  85. ncbi A synthetic lipopolysaccharide-binding peptide based on amino acids 27-39 of serum amyloid P component inhibits lipopolysaccharide-induced responses in human blood
    C J de Haas
    Eijkman Winkler Institute, Department of Inflammation, Utrecht, The Netherlands
    J Immunol 161:3607-15. 1998
    ..N-terminal microsequencing identified this protein as serum amyloid P component (SAP). Purified SAP bound to smooth and rough types of LPS via the lipid A part...
  86. ncbi Experimental erythrocytic malaria infection induces elevated serum amyloid P production in mice
    P Balmer
    Department of Veterinary Parasitology, University of Glasgow, Bearsden Road, G61 1QH, Glasgow, UK
    Immunol Lett 72:147-52. 2000
    ..These observations demonstrate that blood-stage malaria infection induces a systemic APR and that this may contribute to the immune response to infection in an anti-parasitic or immunomodulatory manner...
  87. ncbi Calumenin interacts with serum amyloid P component
    H Vorum
    Department of Medical Biochemistry, Ole Worms Alle, Building 170, University of Aarhus, DK 8000, Aarhus C, Denmark
    FEBS Lett 465:129-34. 2000
    ..Amino acid sequencing identified this protein as serum amyloid P component (SAP)...
  88. ncbi Serum amyloid P component binding to C4b-binding protein
    P Garcia de Frutos
    Department of Clinical Chemistry, Lund University, University Hospital Malmo, Sweden
    J Biol Chem 270:26950-5. 1995
    ..pathway C3 convertase, forms high affinity complexes with anticoagulant protein S and with the pentraxin serum amyloid P component (SAP). SAP is a plasma protein present in all amyloid deposits...
  89. ncbi Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis
    M B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London NW3 2PF, UK
    Nature 417:254-9. 2002
    The normal plasma protein serum amyloid P component (SAP) binds to fibrils in all types of amyloid deposits, and contributes to the pathogenesis of amyloidosis...
  90. pmc Effect of serum amyloid P component level on transthyretin-derived amyloid deposition in a transgenic mouse model of familial amyloidotic polyneuropathy
    T Murakami
    Department of Biochemistry, Kumamoto University Medical School, Japan
    Am J Pathol 141:451-6. 1992
    ..We found that human TTR and mouse serum amyloid P component (SAP) are deposited as amyloid in tissues of these mouse lines...
  91. ncbi Characterization of the long pentraxin PTX3 as a TNFalpha-induced secreted protein of adipose cells
    Anissa Abderrahim-Ferkoune
    Institute of Signaling, Developmental Biology and Cancer Research, Centre de Biochimie, UMR 6543 CNRS, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    J Lipid Res 44:994-1000. 2003
    ..In conclusion, PTX3 appears as a TNFalpha-induced protein that provides a new link between chronic low-level inflammatory state and obesity...
  92. ncbi Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity
    Alberto Mantovani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Vaccine 21:S43-7. 2003
    ..Evidence suggests that PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility...
  93. ncbi Labeling of cerebral amyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice
    Jiong Shi
    Department of Neurology, Case Western Reserve University, University Hospitals of Cleveland, Ohio 44106 4962, USA
    J Nucl Med 43:1044-51. 2002
    ..contain abundant heparan sulfate proteoglycans that can bind basic fibroblast growth factor (bFGF) and serum amyloid P component (SAP), we investigated a novel route of ligand delivery to the brain to assess Abeta deposition in a ..
  94. pmc Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component
    Simon E Kolstoe
    Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, Division of Medicine Royal Free Campus, University College London Medical School, London NW3 2PF, United Kingdom
    Proc Natl Acad Sci U S A 106:7619-23. 2009
    New therapeutic approaches in Alzheimer's disease are urgently needed. The normal plasma protein, serum amyloid P component (SAP), is always present in cerebrospinal fluid (CSF) and in the pathognomonic lesions of Alzheimer's disease, ..
  95. ncbi Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain
    Ralph Andre
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Glia 53:477-83. 2006
    ..These results show that IL-1beta exclusively downregulates alpha-syntrophin expression independently of IL-1R1, and suggest the expression of additional functional IL-1 receptors in the CNS...
  96. ncbi Pentraxins as a key component of innate immunity
    Barbara Bottazzi
    Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Curr Opin Immunol 18:10-5. 2006
    ..Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation...
  97. ncbi TSG-14 transgenic mice have improved survival to endotoxemia and to CLP-induced sepsis
    A A Dias
    Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    J Leukoc Biol 69:928-36. 2001
    ..a carboxy-terminal half that shares homology with the entire sequence of C-reactive protein (CRP) and serum amyloid P component (SAP), acute-phase proteins of the pentraxin family...
  98. ncbi Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions
    Daiji Kawanami
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Biochem Biophys Res Commun 314:415-9. 2004
    ..Taken together, these results suggest that the balance in the concentrations of adipocytokines such as resistin and adiponectin determines the inflammation status of vasculature, and in turn the progress of atherosclerosis...
  99. ncbi Clearance of apoptotic cells in human SLE
    U S Gaipl
    Institute for Clinical Immunology, Department of Medicine III, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Curr Dir Autoimmun 9:173-87. 2006
    ..This altered mechanism for the clearance of dying cells may represent a central pathogenic process in the development and acceleration of this autoimmune disease...
  100. ncbi Characterization of the binding of serum amyloid P to type IV collagen
    K Zahedi
    Division of Nephrology, Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 271:14897-902. 1996
    ....
  101. ncbi Single-dose therapy for lupus nephritis: C-reactive protein, nature's own dual scavenger and immunosuppressant
    Carol Anne Ogden
    Arthritis Rheum 52:378-81. 2005

Research Grants97

  1. Modulation of Leukocyte Adhesion by P-selectin/PSGL-1 Signaling
    Jian Guo Geng; Fiscal Year: 2009
    ..Nef-associated factor 1 (Nafl) is an endogenous inhibitor for NF-kappaB activation. Serum amyloid P component (SAP) is an acute phase protein synthesized and secreted rapidly by hepatocytes in response to various ..
  2. Modulation of Leukocyte Adhesion by P-selectin/PSGL-1 Signaling
    Jian Guo Geng; Fiscal Year: 2007
    ..Nef-associated factor 1 (Nafl) is an endogenous inhibitor for NF-kappaB activation. Serum amyloid P component (SAP) is an acute phase protein synthesized and secreted rapidly by hepatocytes in response to various ..
  3. Modulation of Leukocyte Adhesion by P-selectin/PSGL-1 Signaling
    Jian Guo Geng; Fiscal Year: 2010
    ..Nef-associated factor 1 (Nafl) is an endogenous inhibitor for NF-kappaB activation. Serum amyloid P component (SAP) is an acute phase protein synthesized and secreted rapidly by hepatocytes in response to various ..
  4. Targeting C-reactive protein in atherothrombotic disease
    Mark Pepys; Fiscal Year: 2007
    ..abstract_text> ..
  5. Discovery of Alcohol Exposure Biomarkers via Affinity Mass Spectrometry
    URBAN KIERNAN; Fiscal Year: 2006
    ..The ultimate result of this research will be a validated protein biomarker assay(s) that can be used to screen for alcohol exposure. ..
  6. MS based approaches for diabetes biomarker discovery
    URBAN KIERNAN; Fiscal Year: 2007
    ..The ultimate result of this research will be validated protein biomarkers for pre-and type 2 diabetes and technology that are ready for clinical screening and diagnosis of the disease. ..
  7. SPECT/CT Imaging of Systemic AA-Amyloidosis in Mice
    Jonathan Wall; Fiscal Year: 2002
    ..Furthermore, the translation of amyloid-specific imaging technologies will yield tangible clinical benefit...
  8. MOUSE MEMBRANE RCA PROTEINS IN THE IMMUNE RESPONSE
    V Holers; Fiscal Year: 1993
    ....
  9. ANALYSIS OF C3D/EBV RECEPTOR (CR2) LIGAND BINDING SITES
    V Holers; Fiscal Year: 1993
    ..This understanding will allow further experimental and perhaps better clinical approaches to immunotherapy and anti-viral therapy mediated through CR2...
  10. Structure-Function Relationships of C-Reactive Protein
    Alok Agrawal; Fiscal Year: 2006
    ..These studies will provide substantial insight into the mechanisms by which this ancient protein may contribute to host defense, or alternatively, to pathogenesis of disease. ..
  11. Role of IFI16 in Cellular Senescence
    Divaker Choubey; Fiscal Year: 2006
    ..The significance of our proposed experiments is that they will identify molecular mechanisms by which IFI16 regulates the transcription of senescence-associated genes and contributes to the senescence-associated cell cycle arrest. ..
  12. Heavy Drinking & Coronary Disease: Acute/Chronic Effects
    Kenneth Mukamal; Fiscal Year: 2006
    ..These results may prove to have important biological, clinical, and public health implications for the care of CHD. ..
  13. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2010
    ..Our studies will increase the understanding of the molecular basis of sex bias in lupus disease and could potentially lead to better diagnostic tools as well as disease monitoring, and effective treatments. 1 ..
  14. Structure-Function Relationships of C-Reactive Protein
    Alok Agrawal; Fiscal Year: 2010
    ..In addition, the investigation of CRP-complement factor H interactions may also have implications in other areas of clinical medicine such as age-related macular degeneration. ..
  15. 2/2-Ziprasidone Augmentation of SSRIs for Treatment-Resistant Depression (TRD)
    RICHARD CHARLES SHELTON; Fiscal Year: 2010
    ..We estimate that 180 of these patients will enter the double-blind phase. ..
  16. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2009
    ..Our studies will increase the understanding of the molecular basis of sex bias in lupus disease and could potentially lead to better diagnostic tools as well as disease monitoring, and effective treatments. 1 ..
  17. The role of Macrophage Delivered WNT Signaling in kidney injury and repair
    JEREMY DUFFIELD; Fiscal Year: 2009
    ..We will study the molecular components of this complex cell-cell signaling pathway to discover new targets that may lead to new therapies for patients with kidney disease. ..
  18. Role of IFI16 in Cellular Senescence
    Divaker Choubey; Fiscal Year: 2009
    ..abstract_text> ..
  19. Endothelial Dysfunction, Oxidative Stress and Risk of Peripheral Arterial Disease
    Kenneth Mukamal; Fiscal Year: 2009
    ..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..
  20. BIOPHYSICS OF MYELOMA PATHOLOGY
    Fred Stevens; Fiscal Year: 1993
    ..The availability of crystals from representative proteins will permit us to study the structural aspects of light chain aggregation...
  21. MOLECULAR NEUROBIOLOGY OF DEPRESSION
    Richard Shelton; Fiscal Year: 2003
    ..Develop further expertise in basic molecular biological methods; 2. Develop new projects oriented to future funding opportunities; and 3. Continue to mentor the next generation of investigators. ..
  22. PROTEIN STRUCTURE, STABILITY, AND AGING
    Fred Stevens; Fiscal Year: 2003
    ..Such variations, however, are likely to retard, or accelerate, protein degeneration following oxidative stress or other modification, and may influence the rate of appearance of the 'normal' systemic dysfunction during aging. ..
  23. Endothelial Dysfunction, Oxidative Stress and Risk of Peripheral Arterial Disease
    Kenneth Jay Mukamal; Fiscal Year: 2010
    ..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..
  24. Complement in the Pathogenesis of Autoimmune Arthritis
    VERNON HOLERS; Fiscal Year: 2009
    ....
  25. Determinants and Cardiovascular Consequences of Diabetes in Older Adults
    Kenneth Mukamal; Fiscal Year: 2009
    ....
  26. RA-Related Autoantibodies in Healthy FDR of RA Patients
    V Holers; Fiscal Year: 2007
    ....
  27. MOUSE MEMBRANE RCA PROTEINS IN THE IMMUNE RESPONSE
    V Holers; Fiscal Year: 2002
    ....
  28. MOUSE MEMBRANE RCA PROTEINS IN THE IMMUNE RESPONSE
    V Holers; Fiscal Year: 2007
    ..Specific Aim #3: Determine the functional activities and biologic relevance of novel SCR-containing candidate C3/C4 binding and regulatory proteins. ..
  29. RESEARCH TRAINING IN RHEUMATOLOGY
    V Holers; Fiscal Year: 2007
    ..D. scientists who will hold successful academic research positions. ..
  30. Evolution of Autoimmunity in Rheumatoid Arthritis
    V Holers; Fiscal Year: 2005
    ..abstract_text> ..
  31. C3D/EBV RECEPTOR LIGAND BINDING SITES
    V Holers; Fiscal Year: 2006
    ....
  32. Mechanism of Dialysis Arteriovenous Fistula Dysfunction
    Karl Nath; Fiscal Year: 2009
    ..In aggregate, these studies will determine the basis for and the pathogenetic significance of such upregulation of MCP-1, and may suggest strategies for preventing dysfunction of AVFs. ..
  33. DENVER AUTOIMMUNITY CENTER OF EXCELLENCE
    V Holers; Fiscal Year: 2007
    ..This latter project involves a newly established collaboration with a separate institution and group of clinicians skilled in the clinical investigation of RA. ..