Genomes and Genes
serum amyloid p component
Summary: Amyloid P component is a small, non-fibrillar glycoprotein found in normal serum and in all amyloid deposits. It has a pentagonal (pentaxin) structure. It is an acute phase protein, modulates immunologic responses, inhibits ELASTASE, and has been suggested as an indicator of LIVER DISEASE.
Publications187 found, 100 shown here
- Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3Alberto Mantovani
Istituto Clinico Humanitas, Via Manzoni 56, 20089, Milan, Rozzano, Italy
J Clin Immunol 28:1-13. 2008..Evidence suggests that PTX3 is a useful new serological marker, rapidly reflecting tissue inflammation and damage under diverse clinical conditions...
- Biochemical and functional characterization of the interaction between pentraxin 3 and C1qAlma J Nauta
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Eur J Immunol 33:465-73. 2003..Classical short pentraxins, C-reactive protein, and serum amyloid P component can bind to C1q and thereby activate the classical complement pathway...
- Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertilityCecilia Garlanda
Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
Annu Rev Immunol 23:337-66. 2005C reactive protein, the first innate immunity receptor identified, and serum amyloid P component are classic short pentraxins produced in the liver. Long pentraxins, including the prototype PTX3, are expressed in a variety of tissues...
- Serum amyloid P component scintigraphy for diagnosis and monitoring amyloidosisPhilip N Hawkins
Department of Medicine, Royal Free and University College Medical School London, UK
Curr Opin Nephrol Hypertens 11:649-55. 2002b>Serum amyloid P component is a normal plasma protein and a universal non-fibrillar constituent of amyloid deposits...
- Lipopolysaccharide (LPS)-binding synthetic peptides derived from serum amyloid P component neutralize LPSC J de Haas
Department of Inflammation, Eijkman Winkler Institute, University Utrecht, The Netherlands
Infect Immun 67:2790-6. 1999..We showed that serum amyloid P component (SAP) neutralizes LPS...
- Binding of the long pentraxin PTX3 to factor H: interacting domains and function in the regulation of complement activationLivija Deban
Laboratory for Immunology and Inflammation, Instituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, Rozzano, Italy
J Immunol 181:8433-40. 2008..Thus, our findings identify PTX3 as a unique FH ligand in that it can bind both of the two hot-spots of FH, namely SCR7 and SCR19-20 and indicate that PTX3 participates in the localization of functionally active FH...
- Pentraxin 3 and C-reactive protein in severe meningococcal diseaseTom Sprong
Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Shock 31:28-32. 2009..In conclusion, PTX3 was an early indicator of shock in patients with severe meningococcal disease that followed a pattern of induction distinct from CRP...
- Molecular chaperone properties of serum amyloid P componentA R Coker
Division of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, UK
FEBS Lett 473:199-202. 2000The selective binding of serum amyloid P component (SAP) to proteins in the pathological amyloid cross-beta fold suggests a possible chaperone role...
- Serum amyloid P component-DNA complexes are decreased in systemic lupus erythematosus. inverse association with anti-dsDNA antibodiesAnne Voss
Department of Rheumatology, Odense University Hospital, Odense, Denmark
J Rheumatol 35:625-30. 2008To study serum levels of serum amyloid P component (SAP) and SAP-DNA complexes in a population-based cohort of patients with systemic lupus erythematosus (SLE).
- Serum amyloid P component binds to late apoptotic cells and mediates their uptake by monocyte-derived macrophagesMarc Bijl
Department of Internal Medicine, University Hospital, Groningen, The Netherlands
Arthritis Rheum 48:248-54. 2003..We undertook this study to determine whether serum amyloid P component (SAP; a pentraxin that, when deficient in mice, results in lupus-like disease) binds to apoptotic cells ..
- Sustained pharmacological depletion of serum amyloid P component in patients with systemic amyloidosisJulian D Gillmore
Centre for Amyloidosis and Acute Phase Proteins and the National Amyloidosis Centre, University College London Medical School, London, UK
Br J Haematol 148:760-7. 2010b>Serum amyloid P component (SAP) is a universal constituent of amyloid deposits and contributes to their formation and/or persistence...
- PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophagesS N Diniz
Ludwig Institute for Cancer Research, Sao Paulo, Brazil
J Leukoc Biol 75:649-56. 2004..Our results provide evidence for a role of PTX3 as an important component of the innate-immune response and as part of the host mechanisms that control fungal recognition and phagocytosis...
- Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P componentF Breviario
Istituto Ricerche Farmacologiche Mario Negri, Milano, Italy
J Biol Chem 267:22190-7. 1992..beta) has led to the identification of a novel gene (PTX3) related to pentaxins (C-reactive protein and serum amyloid P component in man), a subclass of acute phase proteins...
- Binding of Ca2+, Mg2+, and heparin by human serum amyloid P component in affinity capillary electrophoresisNiels H H Heegaard
Department of Autoimmunology, Statens Serum Institut, Copenhagen S, Denmark
Electrophoresis 27:2609-15. 2006Human serum amyloid P component (SAP) is a glycoprotein circulating in the blood and found in association with all types of amyloid (malfolded potein aggregates) examined so far...
- Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune responseCecilia Garlanda
Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
Nature 420:182-6. 2002..The classical short pentraxins, C-reactive protein (CRP) and serum amyloid P component (SAP), are acute-phase proteins produced in the liver in response to inflammatory mediators...
- Labeling of cerebral amyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in miceJiong Shi
Department of Neurology, Case Western Reserve University, University Hospitals of Cleveland, Ohio 44106-4962, USA
J Nucl Med 43:1044-51. 2002..contain abundant heparan sulfate proteoglycans that can bind basic fibroblast growth factor (bFGF) and serum amyloid P component (SAP), we investigated a novel route of ligand delivery to the brain to assess Abeta deposition in a ..
- Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosisM B Pepys
Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London NW3 2PF, UK
Nature 417:254-9. 2002The normal plasma protein serum amyloid P component (SAP) binds to fibrils in all types of amyloid deposits, and contributes to the pathogenesis of amyloidosis...
- High-volume ventilation induces pentraxin 3 expression in multiple acute lung injury models in ratsDaisuke Okutani
Thoracic Surgery Research Laboratory, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
Am J Physiol Lung Cell Mol Physiol 292:L144-53. 2007..A local expression of PTX3 induced by high-volume ventilation, either alone or in combination with other pathological conditions, suggests that it may be an important mediator in ventilator-induced lung injury...
- Increased mortality and inflammation in tumor necrosis factor-stimulated gene-14 transgenic mice after ischemia and reperfusion injuryDanielle G Souza
Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Am J Pathol 160:1755-65. 2002..Taken together, our data point to a critical role of TSG-14 in controlling acute inflammatory response in part via the modulation of TNF-alpha expression...
- Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activationAntonio Inforzato
Department of Biology, University Tor Vergata, Rome, Italy
Biochemistry 45:11540-51. 2006..In conclusion, our results provided evidence of an involvement of the PTX3 sugar moiety in C1q recognition and complement activation...
- Establishment of a high sensitivity plasma assay for human pentraxin3 as a marker for unstable angina pectorisKenji Inoue
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4 6 1, Komaba, Meguro, Tokyo, 153 8904, Japan
Arterioscler Thromb Vasc Biol 27:161-7. 2007..To critically evaluate the role of PTX3 in UAP, a sensitive and precise measurement of PTX3 concentration is needed...
- PTX3 in small-vessel vasculitides: an independent indicator of disease activity produced at sites of inflammationF Fazzini
Istituto Scientifico H San Raffaele and Università, Milan, Italy
Arthritis Rheum 44:2841-50. 2001..To verify whether the prototypical long pentraxin PTX3 represents an indicator of the activity of small-vessel vasculitis...
- The long pentraxin 3 in cardiac surgery: distinct responses in "on-pump" and "off-pump" patientsPavel Kunes
Department of Cardiac Surgery, Charles University in Prague, University Hospital and Faculty of Medicine in Hradec Králové, Czech Republic
Scand Cardiovasc J 41:171-9. 2007..The purpose of this study was to assess the kinetics of release of PTX3 in cardiac surgical patients, operated on either with or without the use of cardiopulmonary bypass (CPB)...
- Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3Maura Camozzi
Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, 25123 Brescia, Italy
J Biol Chem 281:22605-13. 2006....
- Proteomic analysis of UVC irradiation-induced damage of plasma proteins: Serum amyloid P component as a major target of photolysisHong-Lin Chan
Ludwig Institute for Cancer Research and Department of Biochemistry and Molecular Biology, University College London, Cruciform Building, Gower Street, London WC1E 6BT, UK
FEBS Lett 580:3229-36. 2006..We identify a number of the damaged proteins by mass spectrometry, including serum amyloid P component, and further demonstrate UVC-induced photolysis of its disulphide bond.
- Characterization of the long pentraxin PTX3 as a TNFalpha-induced secreted protein of adipose cellsAnissa Abderrahim-Ferkoune
Institute of Signaling, Developmental Biology and Cancer Research, Centre de Biochimie, UMR 6543 CNRS, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
J Lipid Res 44:994-1000. 2003..In conclusion, PTX3 appears as a TNFalpha-induced protein that provides a new link between chronic low-level inflammatory state and obesity...
- Serum amyloid P component in mink, a non-glycosylated protein with affinity for phosphorylethanolamine and phosphorylcholineLone A Omtvedt
Department of Rheumatology Institute of Immunology, Rikshospitalet, University of Oslo, Blindern, Norway
Amyloid 11:101-8. 2004..In the present work, we have characterized the serum amyloid P component (SAP) in mink...
- Prognostic significance of the long pentraxin PTX3 in acute myocardial infarctionRoberto Latini
Mario Negri Institute for Pharmacological Research, Milan, Italy
Circulation 110:2349-54. 2004..The aim of this study was to assess the prognostic value of PTX3 in MI compared with the best-known and clinically relevant biological markers...
- TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNKBing Han
Thoracic Surgery Research Laboratory, University Health Network Toronto General Research Institute, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
J Immunol 175:8303-11. 2005..The importance of the JNK pathway for the regulated PTX3 expression may be a potential target for its regulation in the lung...
- Proteomic characterization of novel serum amyloid P component variants from human plasma and urineUrban A Kiernan
Intrinsic Bioprobes Inc, Tempe, AZ 85281, USA
Proteomics 4:1825-9. 2004b>Serum amyloid P component (SAP) is a human plasma protein that has been widely studied for its influence on amyloid plaque formation and stabilization...
- Protective molecules--C-reactive protein (CRP), serum amyloid P (SAP), pentraxin3 (PTX3), mannose-binding lectin (MBL), and apolipoprotein A1 (Apo A1), and their autoantibodies: prevalence and clinical significance in autoimmunityMartine Szyper Kravitz
Center for Autoimmune Diseases and Department of Medicine B, Chaim Sheba Medical Center Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
J Clin Immunol 25:582-91. 2005....
- Serum amyloid P-component-mediated inhibition of the uptake of Mycobacterium tuberculosis by macrophages, in vitroS Kaur
National Institute of Pharmaceutical Education and Research, S.A.S Nagar, Punjab, India
Scand J Immunol 59:425-31. 2004..tuberculosis Erdman by mouse AMs, which was also associated with their reduced intracellular growth...
- Serum amyloid P and cardiovascular disease in older men and women: results from the Cardiovascular Health StudyNancy Swords Jenny
Department of Pathology, College of Medicine, University of Vermont, 208 South Park Drive, Suite 2, Colchester, VT 05446, USA
Arterioscler Thromb Vasc Biol 27:352-8. 2007..Serum amyloid P (SAP), a pentraxin like C-reactive protein (CRP), functions in innate immunity. However, associations of SAP with cardiovascular disease (CVD) are unknown...
- Regulation of PTX3, a key component of humoral innate immunity in human dendritic cells: stimulation by IL-10 and inhibition by IFN-gammaAndrea Doni
Istituto Clinico Humanitas (ICH, Via Manzoni, 56 20089 Rozzano, Milan, Italy
J Leukoc Biol 79:797-802. 2006..As PTX3 is also an extracellular matrix component, IL-10-enhanced PTX3 production may play a role in orchestration of tissue remodeling in chronic inflammation...
- PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilizationAntonietta Salustri
Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome 00133, Italy
Development 131:1577-86. 2004..Thus, PTX3 is a structural constituent of the cumulus oophorus extracellular matrix essential for female fertility...
- The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertilityBarbara Bottazzi
Istituto Clinico Humanitas, Rozzano, Milan, Italy
J Leukoc Biol 79:909-12. 2006..Thus, the prototypic long pentraxin PTX3 is a multifunctional, soluble pattern recognition receptor acting as a nonredundant component of the humoral arm of innate immunity and involved in matrix deposition and female fertility...
- C-reactive protein and cardiovascular disease: new insights from an old moleculeG M Hirschfield
Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, Royal Free Campus, London, UK
QJM 96:793-807. 2003..We review the biological properties of CRP, the association between CRP and cardiovascular disease, and the possibility that CRP may be a novel therapeutic target...
- Serum amyloid P component binding to Shiga toxin 2 requires both a subunit and B pentamerPaola Marcato
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
Infect Immun 71:6075-8. 2003..A polyvalent globotriaosyl-ceramide receptor analog, Daisy, did not competitively inhibit HuSAP binding, implying that the two ligands bind to different Stx2 domains...
- Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunityAlberto Mantovani
Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Vaccine 21:S43-7. 2003..Evidence suggests that PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility...
- Human serum amyloid P component protects against Escherichia coli O157:H7 Shiga toxin 2 in vivo: therapeutic implications for hemolytic-uremic syndromeGlen D Armstrong
Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Canada
J Infect Dis 193:1120-4. 2006..Here, we show that serum amyloid P component (SAP), a normal human plasma protein, specifically protects mice against the lethal toxicity of Stx2, ..
- Glycosaminoglycans inhibit neurodegenerative effects of serum amyloid P component in vitroZoltán Urbányi
Laboratory of Molecular Neurobiological Research, Gedeon Richter Ltd, PO Box 27, H 1475 Budapest 10, Hungary
Neurochem Int 46:471-7. 2005b>Serum amyloid P component, a member of pentraxin serum protein family, has been suggested to contribute to the progression of neurodegeneration including Alzheimer's disease by binding to beta-amyloid fibrils leading to an increased ..
- Mice lacking serum amyloid P component do not necessarily develop severe autoimmune diseaseM Soma
First Department of Biochemistry, Yamanashi Medical University, 1110 Shimokato, Tamaho cho, Nakakoma gun, Yamanashi 409 3898, Japan
Biochem Biophys Res Commun 286:200-5. 2001b>Serum amyloid P component (SAP) is a major acute-phase reactant in mice. Recently, it was reported that SAP-deficient mice spontaneously developed anti-nuclear antibodies and severe glomerulonephritis...
- The long pentraxin PTX3 in human endometrium: regulation by steroids and trophoblast productsRoxana M Popovici
Department of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, Voss Strasse 9, 69115 Heidelberg, Germany
Endocrinology 149:1136-43. 2008..Also, of the factors secreted by trophoblast, IL-1beta induces PTX3 in human endometrial stromal cells...
- A synthetic lipopolysaccharide-binding peptide based on amino acids 27-39 of serum amyloid P component inhibits lipopolysaccharide-induced responses in human bloodC J de Haas
Eijkman Winkler Institute, Department of Inflammation, Utrecht, The Netherlands
J Immunol 161:3607-15. 1998..N-terminal microsequencing identified this protein as serum amyloid P component (SAP). Purified SAP bound to smooth and rough types of LPS via the lipid A part...
- Influenza virus infection is not affected by serum amyloid P componentJeff Herbert
Department of Medicine, Royal Free and University College Medical School, London, UK
Mol Med 8:9-15. 2002Binding of serum amyloid P component (SAP) to its ligands, including bacteria, chromatin and amyloid fibrils, protects them from degradation, is anti-opsonic and anti-immunogenic...
- Pentraxin 3, a new marker for vascular inflammation, predicts adverse clinical outcomes in patients with heart failureSatoshi Suzuki
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
Am Heart J 155:75-81. 2008..The purpose of the present study was to examine the clinical significance of plasma PTX3 levels in patients with heart failure...
- Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P componentB Bottazzi
From the Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
J Biol Chem 272:32817-23. 1997..binding properties of human PTX3, in comparison with the classical pentraxins C-reactive protein and serum amyloid P component. Sequencing of Chinese hamster ovary cell-expressed PTX3 revealed that the mature secreted protein ..
- Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component geneM Botto
Rheumatology Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
Nat Med 3:855-9. 1997..amyloidosis, Alzheimer's disease and the transmissible spongiform encephalopathies always contain serum amyloid P component (SAP) bound to the amyloid fibrils...
- Relationship of TSG-14 protein to the pentraxin family of major acute phase proteinsG W Lee
Department of Microbiology, New York University Medical Center, NY 10016
J Immunol 153:3700-7. 1994..encodes a secreted glycoprotein with significant sequence homology to C-reactive protein (CRP) and serum amyloid P component (SAP), members of the pentraxin family of acute phase proteins...
- Serum amyloid P component binding to C4b-binding proteinP Garcia de Frutos
Department of Clinical Chemistry, Lund University, University Hospital Malmo, Sweden
J Biol Chem 270:26950-5. 1995..pathway C3 convertase, forms high affinity complexes with anticoagulant protein S and with the pentraxin serum amyloid P component (SAP). SAP is a plasma protein present in all amyloid deposits...
- Expression of pentraxin 3 (PTX3) in human atherosclerotic lesionsAs Savchenko
Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
J Pathol 215:48-55. 2008..Interestingly, we also clearly observed PTX3-positive neutrophils infiltrating into atherosclerotic plaques, suggesting that PTX3 derived from neutrophils as well as macrophages plays an important role in atherogenesis...
- Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sitesM Introna
Istituto di Recerche Farmacologiche Mario Negri, Milano, Italy
Blood 87:1862-72. 1996Pentraxins, which include C reactive protein (CRP) and serum amyloid P component (SAP), are prototypic acute phase reactants that serve as indicators of inflammatory reactions...
- Human serum amyloid P component oligomers bind and activate the classical complement pathway via residues 14-26 and 76-92 of the A chain collagen-like region of C1qS C Ying
Department of Immunology Microbiology, Rush Medical College, Chicago, IL 60612
J Immunol 150:169-76. 1993b>Serum amyloid P component (SAP) was polymerized using the cleavable cross-linker 3,3'-dithio-bis-(sulfo-succinimidylpropionate) to study its interaction with the C system...
- Calumenin interacts with serum amyloid P componentH Vorum
Department of Medical Biochemistry, Ole Worms Alle, Building 170, University of Aarhus, DK 8000, Aarhus C, Denmark
FEBS Lett 465:129-34. 2000..Amino acid sequencing identified this protein as serum amyloid P component (SAP)...
- Expression of a long pentraxin, PTX3, by monocytes exposed to the mycobacterial cell wall component lipoarabinomannanV Vouret-Craviari
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Infect Immun 65:1345-50. 1997..The significance of PTX3 in the immunobiology of mycobacterial infection and its relevance in relation to clinical involvement remain to be determined...
- Effect of serum amyloid P component level on transthyretin-derived amyloid deposition in a transgenic mouse model of familial amyloidotic polyneuropathyT Murakami
Department of Biochemistry, Kumamoto University Medical School, Japan
Am J Pathol 141:451-6. 1992..We found that human TTR and mouse serum amyloid P component (SAP) are deposited as amyloid in tissues of these mouse lines...
- Serum amyloid P component and C-reactive protein mediate phagocytosis through murine Fc gamma RsC Mold
Department of Molecular Genetics and Microbiology, Veterans Affairs Medical Center, and Department of Medicine, University of New Mexico, Albuquerque, NM 87131, USA
J Immunol 166:1200-5. 2001The pentraxins, serum amyloid P component (SAP) and C-reactive protein (CRP) are acute-phase serum proteins in mice and humans, respectively...
- The pentraxin serum amyloid P component is found in the male genital tract and attached to spermatozoaJohan Malm
Division of Clinical Chemistry, Department of Laboratory Medicine, Lund University, University Hospital MAS, Malmo, Sweden
Int J Androl 31:508-17. 2008b>Serum amyloid P component (SAP) belongs to the pentraxin family of proteins, members of which are characterized by radial pentameric structure and calcium-dependent ligand binding...
- Chromatin-independent binding of serum amyloid P component to apoptotic cellsA Familian
CLB, Sanquin Blood Supply Foundation and Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 167:647-54. 2001Human serum amyloid P component (SAP) is a glycoprotein structurally belonging to the pentraxin family of proteins, which has a characteristic pentameric organization...
- PTX3, A prototypical long pentraxin, is an early indicator of acute myocardial infarction in humansG Peri
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Circulation 102:636-41. 2000..The possibility that PTX3 is altered in patients with acute myocardial infarction (AMI) has not yet been tested...
- Experimental erythrocytic malaria infection induces elevated serum amyloid P production in miceP Balmer
Department of Veterinary Parasitology, University of Glasgow, Bearsden Road, G61 1QH, Glasgow, UK
Immunol Lett 72:147-52. 2000..These observations demonstrate that blood-stage malaria infection induces a systemic APR and that this may contribute to the immune response to infection in an anti-parasitic or immunomodulatory manner...
- Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P componentSimon E Kolstoe
Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, Division of Medicine Royal Free Campus, University College London Medical School, London NW3 2PF, United Kingdom
Proc Natl Acad Sci U S A 106:7619-23. 2009New therapeutic approaches in Alzheimer's disease are urgently needed. The normal plasma protein, serum amyloid P component (SAP), is always present in cerebrospinal fluid (CSF) and in the pathognomonic lesions of Alzheimer's disease, ..
- The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells, and edits the cross-presentation of self, viral, and tumor antigensParamita Baruah
Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Institute, Milan, Italy
Blood 107:151-8. 2006..These data suggest that PTX3 acts as a third-party agent between microbial stimuli and dying cells, contributing to limit tissue damage under inflammatory conditions and the activation of autoreactive T cells...
- Estrogen treatment abrogates neointima formation in human C-reactive protein transgenic miceDajun Wang
Division of Cardiovascular Disease, University of Alabama, Birmingham, Alabama 35294-0006, USA
Arterioscler Thromb Vasc Biol 25:2094-9. 2005..E2 reduces both neointima formation and neointimal expression of human CRP, suggesting that E2 is vasoprotective...
- Gene regulation by IL-1beta independent of IL-1R1 in the mouse brainRalph Andre
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
Glia 53:477-83. 2006..These results show that IL-1beta exclusively downregulates alpha-syntrophin expression independently of IL-1R1, and suggest the expression of additional functional IL-1 receptors in the CNS...
- Pentraxins as a key component of innate immunityBarbara Bottazzi
Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, Italy
Curr Opin Immunol 18:10-5. 2006..Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation...
- HDL, PTX3, and vascular protectionZiad Mallat
Arterioscler Thromb Vasc Biol 28:809-11. 2008
- Chorionic gonadotropin up-regulates long pentraxin 3 expression in myeloid cellsHui Wan
Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
J Leukoc Biol 84:1346-52. 2008..The hCG-induced hormones progesterone and estrogen also increase the PTX3 production by human monocytes. In conclusion, hCG increases innate immunity via induction of PTX3 in myeloid cells...
- Innate immunity and atherogenesisM Rattazzi
Dipartimento di Medicina Clinica e Sperimentale, , Treviso, Italy
Lupus 14:747-51. 2005..On the other, they could become an additional potential target for therapeutic strategies...
- Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegenerationColm Cunningham
CNS Inflammation Group, School of Biological Sciences, Southampton, Hampshire SO16 7PX, United Kingdom
J Neurosci 25:9275-84. 2005..The finding that a single acute systemic inflammatory event can induce neuronal death in the CNS has implications for therapy in neurodegenerative diseases...
- FcgammaRIIB mediates C-reactive protein inhibition of endothelial NO synthaseChieko Mineo
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA
Circ Res 97:1124-31. 2005..Thus FcgammaRIIB mediates CRP inhibition of eNOS via PP2A, providing a mechanistic link between CRP and endothelial dysfunction...
- Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesisMarco Rusnati
Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
Blood 104:92-9. 2004..PTX3/FGF2 interaction may modulate angiogenesis in various physiopathologic conditions driven by inflammation, innate immunity, and/or neoplastic transformation...
- Antiviral activity of the long chain pentraxin PTX3 against influenza virusesPatrick C Reading
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
J Immunol 180:3391-8. 2008....
- Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degenerationKarine Palin
CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
Neurobiol Dis 30:19-29. 2008....
- PTX3 interacts with inter-alpha-trypsin inhibitor: implications for hyaluronan organization and cumulus oophorus expansionLaura Scarchilli
Department of Public Health and Cell Biology, University of Rome Tor Vergata, 00133 Rome
J Biol Chem 282:30161-70. 2007....
- The long pentraxin PTX3 in vascular pathologyAlberto Mantovani
Research Laboratory in Immunology and Inflammation, Istituto Clinico Humanitas Via Manzoni, 56, 20089 Rozzano, Milan, Italy
Vascul Pharmacol 45:326-30. 2006....
- Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activationSilvia Bozza
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
Blood 108:3387-96. 2006....
- [The role of long pentraxin 3, a new inflammatory mediator in inflammatory responses]Daisuke Okutani
Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine and Dentistry
Nihon Rinsho Meneki Gakkai Kaishi 29:107-13. 2006..Clinical evidence has demonstrated that the elevated PTX3 levels might be a useful early and sensitive marker for severely ill patients. Further studies will definitely be needed to deepen our understanding of PTX3...
- Complement dependent amplification of the innate response to a cognate microbial ligand by the long pentraxin PTX3Alessia Cotena
Istituto Clinico Humanitas, Rozzano Milan, Italy
J Immunol 179:6311-7. 2007..The results reported here demonstrate that PTX3 activates a complement-dependent humoral amplification loop of the innate response to a microbial ligand...
- Macrophage receptors implicated in the "adaptive" form of innate immunityD M E Bowdish
Sir William Dunn School of Pathology, University of Oxford, 10 South Parks Road, Oxford OX1 3RE, UK
Microbes Infect 9:1680-7. 2007..This results in increased recognition of a broad spectrum of pathogens, enhancement of effector functions and altered regulation of the inflammatory response...
- Lipopolysaccharide induced expression of pentraxin 3 in human neutrophils and monocyte-derived macrophagesMasaru Imamura
Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Chuou ku, Niigata 951 8510, Japan
Cell Immunol 248:86-94. 2007..We believe that PTX3 can contribute as a diagnostic tool to evaluate inflammation at peripheral sites...
- Science and serendipityMark B Pepys
Department of Medicine, Hampstead Campus, University College London
Clin Med 7:562-78. 2007..Work on the pentraxin proteins, C-reactive protein (CRP) and serum amyloid P component (SAP), and on amyloidosis, has benefited from abundant serendipity, leading to routine clinical use of ..
- Inflammatory status in patients with chronic renal failure: the role of PTX3 and pro-inflammatory cytokinesGrazia Malaponte
Department of Biomedical Sciences, University of Catania, 95124 Catania, Italy
Int J Mol Med 20:471-81. 2007..Collectively, these data suggest that PTX3 protein may represent an additional and stable marker of inflammation in CRF...
- Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cellsGiuseppe Danilo Norata
Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
Arterioscler Thromb Vasc Biol 28:925-31. 2008....
- Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory responseKezhong Zhang
Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
Cell 124:587-99. 2006..Together, our studies delineate a molecular mechanism for activation of an ER-localized transcription factor, CREBH, and reveal an unprecedented link by which ER stress initiates an acute inflammatory response...
- Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organizationAntonio Inforzato
Sigma Tau Research and Development, Via Pontina Km 30 400, Pomezia, Italy
J Biol Chem 283:10147-61. 2008..These findings indicate that protein oligomerization is essential for PTX3 activity within the cumulus matrix and implicate PTX3 tetramers as the functional molecular units required for cumulus matrix organization and stabilization...
- Clearance of apoptotic cells in human SLEU S Gaipl
Institute for Clinical Immunology, Department of Medicine III, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Curr Dir Autoimmun 9:173-87. 2006..This altered mechanism for the clearance of dying cells may represent a central pathogenic process in the development and acceleration of this autoimmune disease...
- The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular trapsSebastien Jaillon
Institut National de la Sante et de la Recherche Medicale, Equipe Avenir, Unité 564, University Hospital of Angers, University of Angers, Angers 49933, France
J Exp Med 204:793-804. 2007..Thus, neutrophils serve as a reservoir, ready for rapid release, of the long PTX3, a key component of humoral innate immunity with opsonic activity...
- [The role of pentraxin 3 in the inflammatory and immune response]P Kunes
Kardiochirurgická klinika FN a LF UK, Hradec Kralove
Cas Lek Cesk 144:377-82; discussion 382-4. 2005..e. C-reactive protein and the serum amyloid P component. There are, however, several important differences between the two groups of pentraxins that will be ..
- Characterization of the binding of serum amyloid P to type IV collagenK Zahedi
Division of Nephrology, Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 271:14897-902. 1996....
- Promoter structure and transcriptional activation of the murine TSG-14 gene encoding a tumor necrosis factor/interleukin-1-inducible pentraxin proteinA Altmeyer
Department of Microbiology, New York University Medical Center, New York 10016, USA
J Biol Chem 270:25584-90. 1995..to proteins of the pentraxin family, which includes the acute phase reactants C-reactive protein and serum amyloid P component. Levels of TSG-14 protein (also termed PTX-3) become elevated in the serum of mice and humans after ..
- Unicentric Castleman's disease complicated by systemic AA amyloidosis: a curable diseaseH J Lachmann
NHS National Amyloidosis Centre and the Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, Royal Free Campus, London, UK
QJM 95:211-8. 2002..All types may be complicated by acquired systemic amyloidosis, usually of AA type, but occasionally of AL type associated with monoclonal gammopathy...
- Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactionsDaiji Kawanami
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
Biochem Biophys Res Commun 314:415-9. 2004..Taken together, these results suggest that the balance in the concentrations of adipocytokines such as resistin and adiponectin determines the inflammation status of vasculature, and in turn the progress of atherosclerosis...
- Structure of pentameric human serum amyloid P componentJ Emsley
Laboratory of Molecular Biology, Birkbeck College, London, UK
Nature 367:338-45. 1994The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins...
- Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi's sarcoma cellsMariam Klouche
Institute of Clinical Pathology, Department of Laboratory Medicine, Robert Bosch Hospital and Robert Bosch Society for Medical Research, Stuttgart, Germany
AIDS 16:F9-18. 2002..To analyse if human herpesvirus 8 (HHV8)-derived viral interleukin-6 (vIL-6) has the capacity to activate Kaposi's sarcoma (KS) cells to elicit a local acute-phase response...
- Long pentraxin PTX3 upregulates tissue factor expression in human endothelial cells: a novel link between vascular inflammation and clotting activationEmanuela Napoleone
Antonio Taticchi Unit for Atherosclerosis and Thrombosis, Department of Vascular Medicine and Pharmacology, Istituto Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, S Maria Imbaro, Italy
Arterioscler Thromb Vasc Biol 22:782-7. 2002..Our results suggest that PTX3, by increasing TF expression, potentially plays a role in thrombogenesis and ischemic vascular disease...
- Transgenic sickle mice have vascular inflammationJohn D Belcher
Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis 55455, USA
Blood 101:3953-9. 2003..006) in NY-S sickle mouse lungs. We conclude that transgenic sickle mice are good models to study vascular inflammation and the potential benefit of anti-inflammatory therapies to prevent vaso-occlusion in sickle cell disease...
- Serum amyloid P component and C-reactive protein opsonize apoptotic cells for phagocytosis through Fcgamma receptorsCarolyn Mold
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87108, USA
J Autoimmun 19:147-54. 2002b>Serum amyloid P component (SAP) and C-reactive protein (CRP) are opsonins that react with nuclear autoantigens targeted in systemic autoimmunity...
- Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertilitySimona Varani
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Endocrinol 16:1154-67. 2002..These studies demonstrate that PTX3 plays important roles in cumulus cell-oocyte interaction in the periovulatory period as a downstream protein in the GDF-9 signal transduction cascade...
- Cytokine-induced gene expression at the crossroads of innate immunity, inflammation and fertility: TSG-6 and PTX3/TSG-14Hans Georg Wisniewski
Department of Microbiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
Cytokine Growth Factor Rev 15:129-46. 2004..Female mice with a targeted disruption of either the TSG-6 or PTX3 gene show severe defects in fertility...
- Acute phase proteins in salmonids: evolutionary analyses and acute phase responseL E Jensen
Department of Genetics and Biotechnology Institute, Trinity College, Dublin, Ireland
J Immunol 158:384-92. 1997..Serum amyloid A (SAA) and the pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP) are major AP proteins: their serum levels can rise by 1000-fold, indicating that they play a ..
- Modulation of Leukocyte Adhesion by P-selectin/PSGL-1 SignalingJian Guo Geng; Fiscal Year: 2009..Nef-associated factor 1 (Nafl) is an endogenous inhibitor for NF-kappaB activation. Serum amyloid P component (SAP) is an acute phase protein synthesized and secreted rapidly by hepatocytes in response to various ..
- Modulation of Leukocyte Adhesion by P-selectin/PSGL-1 SignalingJian Guo Geng; Fiscal Year: 2007..Nef-associated factor 1 (Nafl) is an endogenous inhibitor for NF-kappaB activation. Serum amyloid P component (SAP) is an acute phase protein synthesized and secreted rapidly by hepatocytes in response to various ..
- Modulation of Leukocyte Adhesion by P-selectin/PSGL-1 SignalingJian Guo Geng; Fiscal Year: 2010..Nef-associated factor 1 (Nafl) is an endogenous inhibitor for NF-kappaB activation. Serum amyloid P component (SAP) is an acute phase protein synthesized and secreted rapidly by hepatocytes in response to various ..
- Targeting C-reactive protein in atherothrombotic diseaseMark Pepys; Fiscal Year: 2007..abstract_text> ..
- MS based approaches for diabetes biomarker discoveryURBAN KIERNAN; Fiscal Year: 2007..The ultimate result of this research will be validated protein biomarkers for pre-and type 2 diabetes and technology that are ready for clinical screening and diagnosis of the disease. ..
- Discovery of Alcohol Exposure Biomarkers via Affinity Mass SpectrometryURBAN KIERNAN; Fiscal Year: 2006..The ultimate result of this research will be a validated protein biomarker assay(s) that can be used to screen for alcohol exposure. ..
- Role of IFI16 in Cellular SenescenceDivaker Choubey; Fiscal Year: 2006..The significance of our proposed experiments is that they will identify molecular mechanisms by which IFI16 regulates the transcription of senescence-associated genes and contributes to the senescence-associated cell cycle arrest. ..
- Heavy Drinking & Coronary Disease: Acute/Chronic EffectsKenneth Mukamal; Fiscal Year: 2006..These results may prove to have important biological, clinical, and public health implications for the care of CHD. ..
- Gender-Specific Role of p202 in Lupus SusceptibilityDivaker Choubey; Fiscal Year: 2010..Our studies will increase the understanding of the molecular basis of sex bias in lupus disease and could potentially lead to better diagnostic tools as well as disease monitoring, and effective treatments. 1 ..
- Role of IFI16 in Cellular SenescenceDivaker Choubey; Fiscal Year: 2009..abstract_text> ..
- Endothelial Dysfunction, Oxidative Stress and Risk of Peripheral Arterial DiseaseKenneth Mukamal; Fiscal Year: 2009..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..
- 2/2-Ziprasidone Augmentation of SSRIs for Treatment-Resistant Depression (TRD)RICHARD CHARLES SHELTON; Fiscal Year: 2010..We estimate that 180 of these patients will enter the double-blind phase. ..
- The role of Macrophage Delivered WNT Signaling in kidney injury and repairJEREMY DUFFIELD; Fiscal Year: 2009..We will study the molecular components of this complex cell-cell signaling pathway to discover new targets that may lead to new therapies for patients with kidney disease. ..
- Gender-Specific Role of p202 in Lupus SusceptibilityDivaker Choubey; Fiscal Year: 2009..Our studies will increase the understanding of the molecular basis of sex bias in lupus disease and could potentially lead to better diagnostic tools as well as disease monitoring, and effective treatments. 1 ..
- Structure-Function Relationships of C-Reactive ProteinAlok Agrawal; Fiscal Year: 2010..In addition, the investigation of CRP-complement factor H interactions may also have implications in other areas of clinical medicine such as age-related macular degeneration. ..
- MOUSE MEMBRANE RCA PROTEINS IN THE IMMUNE RESPONSEV Holers; Fiscal Year: 1993....
- ANALYSIS OF C3D/EBV RECEPTOR (CR2) LIGAND BINDING SITESV Holers; Fiscal Year: 1993..This understanding will allow further experimental and perhaps better clinical approaches to immunotherapy and anti-viral therapy mediated through CR2...
- BIOPHYSICS OF MYELOMA PATHOLOGYFred Stevens; Fiscal Year: 1993..The availability of crystals from representative proteins will permit us to study the structural aspects of light chain aggregation...
- Structure-Function Relationships of C-Reactive ProteinAlok Agrawal; Fiscal Year: 2006..These studies will provide substantial insight into the mechanisms by which this ancient protein may contribute to host defense, or alternatively, to pathogenesis of disease. ..
- MOLECULAR NEUROBIOLOGY OF DEPRESSIONRichard Shelton; Fiscal Year: 2003..Develop further expertise in basic molecular biological methods; 2. Develop new projects oriented to future funding opportunities; and 3. Continue to mentor the next generation of investigators. ..
- PROTEIN STRUCTURE, STABILITY, AND AGINGFred Stevens; Fiscal Year: 2003..Such variations, however, are likely to retard, or accelerate, protein degeneration following oxidative stress or other modification, and may influence the rate of appearance of the 'normal' systemic dysfunction during aging. ..
- Complement in the Pathogenesis of Autoimmune ArthritisVERNON HOLERS; Fiscal Year: 2009....
- Endothelial Dysfunction, Oxidative Stress and Risk of Peripheral Arterial DiseaseKenneth Jay Mukamal; Fiscal Year: 2010..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..
- Determinants and Cardiovascular Consequences of Diabetes in Older AdultsKenneth Mukamal; Fiscal Year: 2009....
- Evolution of Autoimmunity in Rheumatoid ArthritisV Holers; Fiscal Year: 2005..abstract_text> ..
- MOUSE MEMBRANE RCA PROTEINS IN THE IMMUNE RESPONSEV Holers; Fiscal Year: 2002....
- RESEARCH TRAINING IN RHEUMATOLOGYV Holers; Fiscal Year: 2007..D. scientists who will hold successful academic research positions. ..
- MOUSE MEMBRANE RCA PROTEINS IN THE IMMUNE RESPONSEV Holers; Fiscal Year: 2007..Specific Aim #3: Determine the functional activities and biologic relevance of novel SCR-containing candidate C3/C4 binding and regulatory proteins. ..
- RA-Related Autoantibodies in Healthy FDR of RA PatientsV Holers; Fiscal Year: 2007....
- C3D/EBV RECEPTOR LIGAND BINDING SITESV Holers; Fiscal Year: 2006....
- Mechanism of Dialysis Arteriovenous Fistula DysfunctionKarl Nath; Fiscal Year: 2009..In aggregate, these studies will determine the basis for and the pathogenetic significance of such upregulation of MCP-1, and may suggest strategies for preventing dysfunction of AVFs. ..
- DENVER AUTOIMMUNITY CENTER OF EXCELLENCEV Holers; Fiscal Year: 2007..This latter project involves a newly established collaboration with a separate institution and group of clinicians skilled in the clinical investigation of RA. ..