Genomes and Genes
Summary: A type of extracellularly deposited substance composed of an amyloid protein and additional components including HEPARAN SULFATE PROTEOGLYCAN; LAMININ; COLLAGEN TYPE IV; SERUM AMYLOID P-COMPONENT; and APOLIPOPROTEINS E which together form characteristic amyloid fibrils. The core of amyloid fibrils is formed by the stacking of overlapping beta-pleated sheet domains of the amyloid protein. There are many different amyloid proteins that have been found forming the core of the fibrils in vivo. However, amyloid can be formed from any protein that exposes beta-pleated strand conformations during unfolding or refolding. A common characteristic of amyloid is the ability to bind such dyes as CONGO RED and thioflavine.
Publications332 found, 100 shown here
- Protein misfolding, functional amyloid, and human diseaseFabrizio Chiti
Dipartimento di Scienze Biochimiche, Universita degli Studi di Firenze, I 50134 Firenze, Italy
Annu Rev Biochem 75:333-66. 2006..We review recent advances toward the elucidation of the structures of amyloid fibrils and the mechanisms of their formation at a molecular level...
- Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-BWilliam E Klunk
Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
Ann Neurol 55:306-19. 2004This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls...
- Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetesAlexandra E Butler
Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Diabetes 52:102-10. 2003....
- Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetesSeth L Masters
Immunology Research Centre, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
Nat Immunol 11:897-904. 2010..Here we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid deposits in the pancreas during type 2 diabetes, triggered the ..
- Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memoryRandy L Buckner
Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63105, USA
J Neurosci 25:7709-17. 2005Alzheimer's disease (AD) and antecedent factors associated with AD were explored using amyloid imaging and unbiased measures of longitudinal atrophy in combination with reanalysis of previous metabolic and functional studies...
- Amyloid plaque core protein in Alzheimer disease and Down syndromeC L Masters
Proc Natl Acad Sci U S A 82:4245-9. 1985We have purified and characterized the cerebral amyloid protein that forms the plaque core in Alzheimer disease and in aged individuals with Down syndrome...
- Common structure of soluble amyloid oligomers implies common mechanism of pathogenesisRakez Kayed
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
Science 300:486-9. 2003..Soluble oligomers have a unique distribution in human AD brain that is distinct from fibrillar amyloid. These results indicate that different types of soluble amyloid oligomers have a common structure and suggest ..
- Beta-secretase protein and activity are increased in the neocortex in Alzheimer diseaseHiroaki Fukumoto
Alzheimer Disease Research Unit, Center for Aging, Genetics, and Neurodegeneration, Massachusetts General Hospital East, Bldg 114, Room 2010, 114 16th Street, Charlestown, MA 02129, USA
Arch Neurol 59:1381-9. 2002b>Amyloid plaques, a major pathological feature of Alzheimer disease (AD), are composed of an internal fragment of amyloid precursor protein (APP): the 4-kd amyloid-beta protein (Abeta)...
- Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functionsHeidi Olzscha
Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Martinsried, Germany
Cell 144:67-78. 2011..Here, we have analyzed the gain-of-function toxicity of artificial β sheet proteins that were designed to form amyloid-like fibrils...
- Identifying the amylome, proteins capable of forming amyloid-like fibrilsLukasz Goldschmidt
Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095 1570, USA
Proc Natl Acad Sci U S A 107:3487-92. 2010The amylome is the universe of proteins that are capable of forming amyloid-like fibrils. Here we investigate the factors that enable a protein to belong to the amylome...
- Islet amyloid polypeptide, islet amyloid, and diabetes mellitusPer Westermark
Department of Medical Cell Biology and Immunology, Uppsala University, Uppsala, Sweden
Physiol Rev 91:795-826. 2011Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of the pancreatic islets of Langerhans...
- Atomic view of a toxic amyloid small oligomerArthur Laganowsky
Department of Biological Chemistry, University of California Los Angeles UCLA, Howard Hughes Medical Institute HHMI, Los Angeles, CA 90095, USA
Science 335:1228-31. 2012b>Amyloid diseases, including Alzheimer's, Parkinson's, and the prion conditions, are each associated with a particular protein in fibrillar form...
- A systematic survey identifies prions and illuminates sequence features of prionogenic proteinsSimon Alberti
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Cell 137:146-58. 2009..The self-perpetuating states of these proteins present a vast source of heritable phenotypic variation that increases the adaptability of yeast populations to diverse environments...
- Amyloid precursor protein trafficking, processing, and functionGopal Thinakaran
Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 283:29615-9. 2008Intracellular trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations over the past two decades...
- Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid proteinG G Glenner
Biochem Biophys Res Commun 120:885-90. 1984..This protein may be derived from a unique serum precursor which may provide a diagnostic test for Alzheimer's disease and a means to understand its pathogenesis...
- Functional amyloids as natural storage of peptide hormones in pituitary secretory granulesSamir K Maji
Laboratory of Physical Chemistry, Eidgenossische Technische Hochschule ETH Zurich, Wolfgang Paulistrasse 10, CH 8093 Zurich, Switzerland
Science 325:328-32. 2009..a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation...
- The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptorJ Kang
Nature 325:733-6. 1987Alzheimer's disease is characterized by a widespread functional disturbance of the human brain. Fibrillar amyloid proteins are deposited inside neurons as neurofibrillary tangles and extracellularly as amyloid plaque cores and in blood ..
- The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouseG P Lim
Departments of Medicine and Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
J Neurosci 21:8370-7. 2001..With low-dose but not high-dose curcumin treatment, the astrocytic marker GFAP was reduced, and insoluble beta-amyloid (Abeta), soluble Abeta, and plaque burden were significantly decreased by 43-50%...
- Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's diseaseJia Yao
Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
Proc Natl Acad Sci U S A 106:14670-5. 2009..Mitochondrial amyloid beta (Abeta) level in the 3xTg-AD mice was significantly increased at 9 months and temporally correlated with ..
- Functional amyloid--from bacteria to humansDouglas M Fowler
Department of Chemistry and The Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Trends Biochem Sci 32:217-24. 2007b>Amyloid--a fibrillar, cross beta-sheet quaternary structure--was first discovered in the context of human disease and tissue damage, and was thought to always be detrimental to the host...
- In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18)Dean F Wong
Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0807, USA
J Nucl Med 51:913-20. 2010An (18)F-labeled PET amyloid-beta (Abeta) imaging agent could facilitate the clinical evaluation of late-life cognitive impairment by providing an objective measure for Alzheimer disease (AD) pathology...
- Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695M A Chishti
Centre for Research in Neurodegenerative Diseases, The Department of Laboratory Medicine, Division of Neurology, University Health Network, University of Toronto, Toronto, Ontario M5S 3H2, Canada
J Biol Chem 276:21562-70. 2001..transgenic (Tg) models by exploiting the synergistic effects of familial Alzheimer's disease mutations on amyloid beta-peptide (Abeta) biogenesis...
- Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespanSilvestre Alavez
Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, California 94945, USA
Nature 472:226-9. 2011..A group of small molecules, traditionally used in histopathology to stain amyloid in tissues, bind protein fibrils and slow aggregation in vitro and in cell culture...
- The transcellular spread of cytosolic amyloids, prions, and prionoidsAdriano Aguzzi
Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
Neuron 64:783-90. 2009....
- Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's diseaseKaan E Biron
Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
PLoS ONE 6:e23789. 2011..Cerebrovascular integrity was characterized in Tg2576 AD model mice that overexpress the human amyloid precursor protein (APP) containing the double missense mutations, APPsw, found in a Swedish family, that causes ..
- Mechanism of amyloidogenesis: nucleation-dependent fibrillation versus double-concerted fibrillationGhibom Bhak
School of Chemical and Biological Engineering, College of Engineering, Seoul National University, Seoul, Korea
BMB Rep 42:541-51. 2009..defines a condition in which a soluble and innocuous protein turns to insoluble protein aggregates known as amyloid fibrils...
- Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formationStuart A Sievers
Department of Biological Chemistry, Howard Hughes Medical Institute, UCLA, Box 951970, Los Angeles, California 90095 1570, USA
Nature 475:96-100. 2011Many globular and natively disordered proteins can convert into amyloid fibrils. These fibrils are associated with numerous pathologies as well as with normal cellular functions, and frequently form during protein denaturation...
- Prion-like transmission of protein aggregates in neurodegenerative diseasesPatrik Brundin
Patrik Brundin is at the Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, BMC A10, 221 84 Lund, Sweden
Nat Rev Mol Cell Biol 11:301-7. 2010..The transfer of naked infectious particles between cells could therefore be a target for new disease-modifying therapies...
- Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenanceTristan Bolmont
Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
J Neurosci 28:4283-92. 2008Microglial cells aggregate around amyloid plaques in Alzheimer's disease, but, despite their therapeutic potential, various aspects of their reactive kinetics and role in plaque pathogenesis remain hypothetical...
- An analytical solution to the kinetics of breakable filament assemblyTuomas P J Knowles
Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge CB3 0HE, UK
Science 326:1533-7. 2009..Application to the case of protein aggregation demonstrates that the kinetics of amyloid growth can often be dominated by secondary rather than by primary nucleation events...
- Exploring the sequence determinants of amyloid structure using position-specific scoring matricesSebastian Maurer-Stroh
VIB Switch Laboratory, Flanders Institute for Biotechnology and Vrije Universiteit Brussel, Brussels, Belgium
Nat Methods 7:237-42. 2010..results in beta-sheet-like assemblies that adopt either a variety of amorphous morphologies or ordered amyloid-like structures...
- Biology of amyloid: structure, function, and regulationJason Greenwald
ETH Zurich, Physical Chemistry, ETH Honggerberg, 8093 Zurich, Switzerland
Structure 18:1244-60. 2010..It grows by recruitment of the corresponding amyloid protein, while its repetitiveness can translate what would be a nonspecific activity as monomer into a potent one ..
- 3D structure of Alzheimer's amyloid-beta(1-42) fibrilsThorsten Luhrs
The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 102:17342-7. 2005Alzheimer's disease is the most fatal neurodegenerative disorder wherein the process of amyloid-beta (Abeta) amyloidogenesis appears causative...
- Critical role of amyloid-like oligomers of Drosophila Orb2 in the persistence of memoryAmitabha Majumdar
Stowers Institute for Medical Research, Kansas City, MO 64110, USA
Cell 148:515-29. 2012..Here, we found that the Drosophila CPEB Orb2 forms amyloid-like oligomers, and oligomers are enriched in the synaptic membrane fraction...
- EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomersDagmar E Ehrnhoefer
Max Delbrueck Center for Molecular Medicine, AG Neuroproteomics, 13092 Berlin, Germany
Nat Struct Mol Biol 15:558-66. 2008The accumulation of beta-sheet-rich amyloid fibrils or aggregates is a complex, multistep process that is associated with cellular toxicity in a number of human protein misfolding disorders, including Parkinson's and Alzheimer's diseases...
- The PASTA server for protein aggregation predictionAntonio Trovato
Department of Physics G Galilei, University of Padova, Padova, Italy
Protein Eng Des Sel 20:521-3. 2007Many different proteins aggregate into amyloid fibrils characterized by cross-beta structure. beta-strands contributed by distinct protein molecules are generally found in a parallel in-register alignment...
- Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteinsRandal Halfmann
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Mol Cell 43:72-84. 2011..A systematic survey of prion-forming domains suggested that Q and N residues have distinct effects on amyloid formation...
- Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formationLynette Cegelski
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
Nat Chem Biol 5:913-9. 2009Curli are functional extracellular amyloid fibers produced by uropathogenic Escherichia coli (UPEC) and other Enterobacteriaceae...
- Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humansAnne M Fagan
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Ann Neurol 59:512-9. 2006b>Amyloid-beta(42) (Abeta(42)) appears central to Alzheimer's disease (AD) pathogenesis and is a major component of amyloid plaques. Mean cerebrospinal fluid (CSF) Abeta(42) is decreased in dementia of the Alzheimer's type...
- Annular protofibrils are a structurally and functionally distinct type of amyloid oligomerRakez Kayed
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
J Biol Chem 284:4230-7. 2009b>Amyloid oligomers are believed to play causal roles in several types of amyloid-related neurodegenerative diseases...
- A toxic monomeric conformer of the polyglutamine proteinYoshitaka Nagai
Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
Nat Struct Mol Biol 14:332-40. 2007..conformational transition of the expanded polyQ protein monomer precedes its assembly into beta-sheet-rich amyloid-like fibrils...
- A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse modelGiselle P Lim
Department of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
J Neurosci 25:3032-40. 2005..are unknown, we used the APPsw (Tg2576) transgenic mouse model to evaluate the impact of dietary DHA on amyloid precursor protein (APP) processing and amyloid burden...
- Functional amyloid formation within mammalian tissueDouglas M Fowler
Department of Chemistry, The Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, California, USA
PLoS Biol 4:e6. 2006b>Amyloid is a generally insoluble, fibrous cross-beta sheet protein aggregate. The process of amyloidogenesis is associated with a variety of neurodegenerative diseases including Alzheimer, Parkinson, and Huntington disease...
- Frequent amyloid deposition without significant cognitive impairment among the elderlyHoward Jay Aizenstein
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Arch Neurol 65:1509-17. 2008To characterize the prevalence of amyloid deposition in a clinically unimpaired elderly population, as assessed by Pittsburgh Compound B (PiB) positron emission tomography (PET) imaging, and its relationship to cognitive function, ..
- Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinctMihaela Necula
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
J Biol Chem 282:10311-24. 2007Alzheimer disease is characterized by the abnormal aggregation of amyloid beta peptide into extracellular fibrillar deposits known as amyloid plaques...
- Highly efficient protein misfolding cyclic amplificationNuria Gonzalez-Montalban
Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, Maryland, United States of America
PLoS Pathog 7:e1001277. 2011..The new PMCAb format offers immediate practical benefits and opens new avenues for developing fast ultrasensitive assays and for producing abundant quantities of PrP(Sc)in vitro...
- Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-βJustin M Nussbaum
Department of Biology, University of Virginia, Charlottesville, Virginia 22904, USA
Nature 485:651-5. 2012Extracellular plaques of amyloid-β and intraneuronal neurofibrillary tangles made from tau are the histopathological signatures of Alzheimer's disease...
- The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptidePriyanka Narayan
Department of Chemistry, University of Cambridge, Cambridge, UK
Nat Struct Mol Biol 19:79-83. 2012..We have examined the interactions between human clusterin and the Alzheimer's disease-associated amyloid-β(1-40) peptide (Aβ(1-40)), which is prone to aggregate into an ensemble of oligomeric intermediates implicated ..
- Lipid membranes modulate the structure of islet amyloid polypeptideSajith A Jayasinghe
Department of Biochemistry and Molecular Biology, Zilkha Neurogenetic Institute, University of Southern California, 1501 San Pablo Street, Los Angeles, California 90033, USA
Biochemistry 44:12113-9. 2005The 37-residue islet amyloid polypeptide (IAPP) is thought to play an important role in the pathogenesis of type II diabetes...
- Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficitsRobert Tamayev
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 107:20822-7. 2010According to the prevailing "amyloid cascade hypothesis," genetic dementias such as Alzheimer's disease and familial Danish dementia (FDD) are caused by amyloid deposits that trigger tauopathy, neurodegeneration, and behavioral/cognitive ..
- Amyloid fibers provide structural integrity to Bacillus subtilis biofilmsDiego Romero
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:2230-4. 2010..analyses, in combination with the use of specific dyes and microscopic analyses, indicate that TasA forms amyloid fibers. Consistent with this hypothesis, TasA fibers required harsh treatments (e.g...
- Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of AmyloidosisJean D Sipe
Department of Biochemistry Emerita, Boston University School of Medicine, Boston, MA 02118, USA
Amyloid 17:101-4. 2010A system of amyloid fibril nomenclature based on the chemical identity of the amyloid fibril forming protein is recommended...
- Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic coreChristian Wasmer
Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland
Science 319:1523-6. 2008..We present a structural model based on solid-state nuclear magnetic resonance restraints for amyloid fibrils from the prion-forming domain (residues 218 to 289) of the HET-s protein from the filamentous fungus ..
- Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteinsD R Borchelt
Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Neuron 19:939-45. 1997..of experimental in vitro and in vivo settings, FAD-linked presenilin variants influence the processing of the amyloid precursor protein (APP), leading to elevated levels of the highly fibrillogenic Abeta1-42 peptides that are ..
- Amyloid ion channels: a common structural link for protein-misfolding diseaseArjan Quist
Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
Proc Natl Acad Sci U S A 102:10427-32. 2005..and Parkinson's diseases, result from protein misfolding, giving a distinct fibrillar feature termed amyloid. Recent studies show that only the globular (not fibrillar) conformation of amyloid proteins is sufficient to ..
- ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 miceJames J Donkin
Department of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
J Biol Chem 285:34144-54. 2010..In amyloid mouse models of AD, ABCA1 deficiency exacerbates amyloidogenesis, whereas ABCA1 overexpression ameliorates ..
- FoldAmyloid: a method of prediction of amyloidogenic regions from protein sequenceSergiy O Garbuzynskiy
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia
Bioinformatics 26:326-32. 2010Amyloidogenic regions in polypeptide chains are very important because such regions are responsible for amyloid formation and aggregation. It is useful to be able to predict positions of amyloidogenic regions in protein chains.
- The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer diseaseVeronica Hirsch-Reinshagen
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V4Z 5H5, Canada
J Biol Chem 280:43243-56. 2005..In addition, ABCA1 has been reported to modulate beta-amyloid (Abeta) production in vitro...
- Amyloid imaging in mild cognitive impairment subtypesDavid A Wolk
Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 19104, USA
Ann Neurol 65:557-68. 2009We utilized the amyloid imaging ligand Pittsburgh Compound B (PiB) to determine the presence of Alzheimer's disease (AD) pathology in different mild cognitive impairment (MCI) subtypes and to relate increased PiB binding to other markers ..
- Fibril fragmentation enhances amyloid cytotoxicityWei Feng Xue
Astbury Centre for Structural Molecular Biology, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
J Biol Chem 284:34272-82. 2009Fibrils associated with amyloid disease are molecular assemblies of key biological importance, yet how cells respond to the presence of amyloid remains unclear...
- A diversity of assembly mechanisms of a generic amyloid foldTimo Eichner
Astbury Centre for Structural Molecular Biology and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK
Mol Cell 43:8-18. 2011Protein misfolding and amyloid assembly have long been recognized as being responsible for many devastating human diseases...
- Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer diseaseK Ueda
Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla 92093 0624
Proc Natl Acad Sci U S A 90:11282-6. 1993A neuropathological hallmark of Alzheimer disease (AD) is a widespread amyloid deposition...
- Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?Natalia N Nalivaeva
Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
J Neurochem 120:167-85. 2012The amyloid cascade hypothesis of Alzheimer's disease envisages that the initial elevation of amyloid β-peptide (Aβ) levels, especially of Aβ(1-42) , is the primary trigger for the neuronal cell death specific to onset of Alzheimer'..
- Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrilsJan Bieschke
Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany
Nat Chem Biol 8:93-101. 2012Several lines of evidence indicate that prefibrillar assemblies of amyloid-β (Aβ) polypeptides, such as soluble oligomers or protofibrils, rather than mature, end-stage amyloid fibrils cause neuronal dysfunction and memory impairment ..
- Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic miceChad A Dickey
Alzheimer s Disease Research Laboratory, Department of Pharmacology, University of South Florida, College of Medicine, Tampa, Florida 33612, USA
J Neurosci 23:5219-26. 2003A critical question in Alzheimer's disease (AD) research is the cause of memory loss that leads to dementia. The amyloid precursor protein + presenilin-1 (APP+PS1) transgenic mouse is a model for amyloid deposition, and like AD, the mice ..
- Antimicrobial properties of amyloid peptidesBruce L Kagan
Department of Psychiatry, David Geffen School of Medicine, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90024, USA
Mol Pharm 9:708-17. 2012More than two dozen clinical syndromes known as amyloid diseases are characterized by the buildup of extended insoluble fibrillar deposits in tissues...
- Diversity, biogenesis and function of microbial amyloidsLuz P Blanco
Department of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Trends Microbiol 20:66-73. 2012b>Amyloid is a distinct β-sheet-rich fold that many proteins can acquire...
- Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 miceRadosveta Koldamova
Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 280:43224-35. 2005..To determine further the effect of ABCA1 on amyloid deposition, we used APP23 transgenic mice in which the human familial Swedish AD mutant is expressed only in ..
- The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicityFanling Meng
Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794 3400, USA
Biochemistry 49:8127-33. 2010Islet amyloid polypeptide (IAPP, amylin) is the major protein component of the islet amyloid deposits associated with type 2 diabetes...
- Bovine insulin filaments induced by reducing disulfide bonds show a different morphology, secondary structure, and cell toxicity from intact insulin amyloid fibrilsTamotsu Zako
Bioengineering Laboratory, RIKEN Institute, Saitama, Japan
Biophys J 96:3331-40. 2009b>Amyloid fibrils are associated with more than 20 diseases, including Alzheimer's disease and type II diabetes...
- Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathologyChrista J Maynard
Department of Pathology, The University of Melbourne, VIC 3010, Australia
J Inorg Biochem 100:952-62. 2006The incidence of Alzheimer's disease (AD) is greater in women than men at any age, as is the development of amyloid pathology in several transgenic mouse models of AD...
- Scrambled prion domains form prions and amyloidEric D Ross
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0830, USA
Mol Cell Biol 24:7206-13. 2004The [URE3] prion of Saccharomyces cerevisiae is a self-propagating amyloid form of Ure2p. The amino-terminal prion domain of Ure2p is necessary and sufficient for prion formation and has a high glutamine (Q) and asparagine (N) content...
- Disease-associated amyloid and misfolded protein aggregates activate the inflammasomeSeth L Masters
Immunology Research Centre, Inflammation Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Ireland
Trends Mol Med 17:276-82. 2011..This review discusses the basic research behind these findings and the potential for new therapeutic interventions this affords...
- Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET studyPaul Edison
MRC Clinical Sciences Centre, Cyclotron Building Hammersmith Hospital, Imperial College London, UK
Neurobiol Dis 32:412-9. 200811C](R)PK11195-PET is a marker of activated microglia while [11C]PIB-PET detects raised amyloid load...
- Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infectionNadia R Roan
Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA
Cell Host Microbe 10:541-50. 2011..Here, we report that a subset of these semenogelin fragments form amyloid fibrils that greatly enhance HIV infection...
- Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfoldingZheng Zhou
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
J Biol Chem 284:30148-58. 2009..3) Macromolecular crowding dramatically accelerates amyloid formation by human prion protein...
- Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineeringAnders Sandberg
Institute of Biomedicine, University of Gothenburg, SE 405 30 Gothenburg, Sweden
Proc Natl Acad Sci U S A 107:15595-600. 2010Soluble oligomeric aggregates of the amyloid-beta peptide (Abeta) have been implicated in the pathogenesis of Alzheimer's disease (AD)...
- Molecular mechanism of Thioflavin-T binding to amyloid fibrilsMatthew Biancalana
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Biochim Biophys Acta 1804:1405-12. 2010Intense efforts to detect, diagnose, and analyze the kinetic and structural properties of amyloid fibrils have generated a powerful toolkit of amyloid-specific molecular probes...
- The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individualsBradford C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Cereb Cortex 19:497-510. 2009..Furthermore, subtle thinning is present in asymptomatic older controls with brain amyloid binding as detected with amyloid imaging...
- Two amyloid States of the prion protein display significantly different folding patternsValeriy G Ostapchenko
Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, MD 21201, USA
J Mol Biol 400:908-21. 2010It has been well established that a single amino acid sequence can give rise to several conformationally distinct amyloid states...
- Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathwayTatyana Gurlo
Larry Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 7073, USA
Am J Pathol 176:861-9. 2010The islet in type 2 diabetes mellitus (T2DM) is characterized by a deficit in beta cells and islet amyloid derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by beta cells...
- Amyloid peptide channelsB L Kagan
Department of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine, UCLA, Los Angeles, California 90024 1759, USA
J Membr Biol 202:1-10. 2004..prion diseases), are characterized by the deposition of amorphous, Congo red-staining deposits known as amyloid. These "misfolded" proteins adopt beta-sheet structures and aggregate spontaneously into similar extended fibrils ..
- Stacked sets of parallel, in-register beta-strands of beta2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labelingCarol L Ladner
Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
J Biol Chem 285:17137-47. 2010beta(2)-microglobulin (beta(2)m) is a 99-residue protein with an immunoglobulin fold that forms beta-sheet-rich amyloid fibrils in dialysis-related amyloidosis...
- Conformational variations in an infectious protein determine prion strain differencesMotomasa Tanaka
Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94143, USA
Nature 428:323-8. 2004..Infection of yeast with these different amyloid conformations leads to different [PSI+] strains...
- Molecular basis for insulin fibril assemblyMagdalena I Ivanova
Howard Hughes Medical Institute, UCLA DOE Institute for Genomics and Proteomics, Los Angeles CA 90095 1570, USA
Proc Natl Acad Sci U S A 106:18990-5. 2009..into pairs of tightly interdigitated beta-sheets, each pair displaying the dry steric zipper interface typical of amyloid-like fibrils...
- Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesisLeena Haataja
Larry Hillblom Islet Research Center, UCLA David Geffen School of Medicine, 900 Weyburn Place A, Los Angeles, California 90024 2852, USA
Endocr Rev 29:303-16. 2008..resistance, defective insulin secretion, loss of beta-cell mass with increased beta-cell apoptosis and islet amyloid. The islet amyloid is derived from islet amyloid polypeptide (IAPP, amylin), a protein coexpressed and cosecreted ..
- Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid depositionDonna M Wilcock
Alzheimer s Research Laboratory, University of South Florida, Tampa, Florida 33612, USA
J Neurosci 24:6144-51. 2004The role of microglia in the removal of amyloid deposits after systemically administered anti-Abeta antibodies remains unclear...
- Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formationLiming Hou
Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 7078, USA
J Am Chem Soc 126:1992-2005. 2004..by the aggregation and fibrillation of the 40-residue A beta(1-40) and 42-residue A beta(1-42) peptides into amyloid plaques...
- In vitro conversion of full-length mammalian prion protein produces amyloid form with physical properties of PrP(Sc)Olga V Bocharova
Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
J Mol Biol 346:645-59. 2005..that the infectious agent of prion diseases, PrP(Sc), is composed of the prion protein (PrP) converted into an amyloid-specific conformation...
- Techniques to study amyloid fibril formation in vitroMelanie R Nilsson
Department of Chemistry, McDaniel College, Eaton Hall, 2 College Hill, Westminster, MD 21157, USA
Methods 34:151-60. 2004b>Amyloid fibrils are ordered aggregates of peptides or proteins that are fibrillar in structure and contribute to the complications of many diseases (e.g., type 2 diabetes mellitus, Alzheimer's disease, and primary systemic amyloidosis)...
- Amyloid beta protein: Abeta40 inhibits Abeta42 oligomerizationMegan M Murray
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106 950, USA
J Am Chem Soc 131:6316-7. 2009..Abeta42, however, is significantly more neurotoxic than Abeta40 and forms amyloid fibrils much more rapidly than Abeta40...
- Amyloid efflux transporter expression at the blood-brain barrier declines in normal agingGerald D Silverberg
Department of Neurosurgery, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
J Neuropathol Exp Neurol 69:1034-43. 2010Reduced clearance of amyloid β peptides (Aβ) across the blood-brain barrier contributes to amyloid accumulation in Alzheimer disease...
- Magic angle spinning NMR analysis of beta2-microglobulin amyloid fibrils in two distinct morphologiesGalia T Debelouchina
Department of Chemistry and Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Am Chem Soc 132:10414-23. 2010Beta(2)-microglobulin (beta(2)m) is the major structural component of amyloid fibrils deposited in a condition known as dialysis-related amyloidosis...
- Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's diseaseAnne M Fagan
Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
EMBO Mol Med 1:371-80. 2009..We previously reported that cerebrospinal fluid (CSF) levels of amyloid-beta(42) (Abeta(42)) serve as an excellent marker for brain amyloid as detected by the amyloid tracer, Pittsburgh ..
- Cytosolic accumulation of HPV16 E7 oligomers supports different transformation routes for the prototypic viral oncoprotein: the amyloid-cancer connectionKarina Dantur
Instituto Leloir and Instituto de Investigaciones Bioquímicas Buenos Aires, CONICET, Patricias Argentinas 435, C1405BWE Ciudad Autonoma de Buenos Aires, Argentina
Int J Cancer 125:1902-11. 2009..The protein can form spherical oligomers with amyloid-like properties and chaperone activity...
- The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compoundsSean A Hudson
School of Chemistry and Physics, The University of Adelaide, Australia
FEBS J 276:5960-72. 2009Thioflavin T (ThT) dye fluorescence is used regularly to quantify the formation and inhibition of amyloid fibrils in the presence of anti-amyloidogenic compounds such as polyphenols...
- Disruption of functional connectivity in clinically normal older adults harboring amyloid burdenTrey Hedden
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
J Neurosci 29:12686-94. 2009b>Amyloid deposition is present in 20-50% of nondemented older adults yet the functional consequences remain unclear...
- A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse modelRolf Postina
Institute of Biochemistry, University of Mainz, Mainz, Germany
J Clin Invest 113:1456-64. 2004Alzheimer disease (AD) is characterized by excessive deposition of amyloid beta-peptides (A beta peptides) in the brain...
- Spatial relation between microbleeds and amyloid deposits in amyloid angiopathyGregory A Dierksen
Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Ann Neurol 68:545-8. 2010Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined...
- Amyloid deposits: protection against toxic protein species?Sebastian Treusch
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Cell Cycle 8:1668-74. 2009..In several cases the intracellular and extracellular protein deposits contain a fibrillar protein species called amyloid. However while amyloid deposits are hallmarks of numerous neurodegenerative diseases, their actual role in ..
- Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) depositionAndrei G Vlassenko
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 107:17763-7. 2010b>Amyloid-β (Aβ) plaque deposition can precede the clinical manifestations of dementia of the Alzheimer type (DAT) by many years and can be associated with changes in brain metabolism...
- Preclinical Diagnostic Imaging of AmyloidJonathan S Wall; Fiscal Year: 2010b>Amyloid is associated with a diverse group of often fatal hereditary and sporadic protein misfolding disorders, characterized by the deposition of fibrils and heparan sulfate proteoglycan in vital organs and tissues...
- Implication of HUCBC: a novel therapeutic strategy for Alzheimer's diseaseJun Tan; Fiscal Year: 2010..this downregulation of neurotoxic innate responses and upregulation of salutary humoral responses, A levels/- amyloid deposits and cerebral amyloid angiopathy (CAA;an inflammatory response to vascular amyloid deposits) are reduced ..
- Implication of HUCBC: a novel therapeutic strategy for Alzheimer's diseaseJun Tan; Fiscal Year: 2009..this downregulation of neurotoxic innate responses and upregulation of salutary humoral responses, A levels/- amyloid deposits and cerebral amyloid angiopathy (CAA; an inflammatory response to vascular amyloid deposits) are reduced ..
- Preclinical Diagnostic Imaging of AmyloidJonathan Wall; Fiscal Year: 2009b>Amyloid is associated with a diverse group of often fatal hereditary and sporadic protein misfolding disorders, characterized by the deposition of fibrils and heparan sulfate proteoglycan in vital organs and tissues...
- Mechanisms of Microglial Activation and Phagocytosis in*Gary Landreth; Fiscal Year: 2005Alzheimer's disease is characterized by the extensive deposition of fibrillar forms of beta-amyloid (AB) peptides into the extracellular space, and their compaction into senile plaques...
- Cholesterol and copper affect learning and memoryBERNARD SCHREURS; Fiscal Year: 2007..A high cholesterol diet has been shown to result in beta amyloid deposits - one the hallmarks of Alzheimer's disease...
- SOLUTION STRUCTURE OF THE AMYLOID BETA (1/42)Michael Zagorski; Fiscal Year: 1999DESCRIPTION The 42-residue, beta-(1-42) peptide is the predominant protein component of amyloid plaque core deposits in Alzheimer's disease (AD). The beta-(1-42) nucleates amyloid formation...
- Protein Amyloidogenesis in the Epididymis: Mechanisms and Biological SignificanceGail Cornwall; Fiscal Year: 2009The long range objective of our studies is to determine the biological significance of amyloid-type protein aggregation and mechanisms for its control in the epididymal lumen using the cystatins as molecular models...
- Protein Amyloidogenesis in the Epididymis: Mechanisms and Biological SignificanceGail Cornwall; Fiscal Year: 2010The long range objective of our studies is to determine the biological significance of amyloid-type protein aggregation and mechanisms for its control in the epididymal lumen using the cystatins as molecular models...
- Proteoglycans/Glycosaminoglycans in APP Transgenic MiceALAN SNOW; Fiscal Year: 2004..AD is characterized by the accumulation of insoluble fibrillar amyloid deposits containing the beta-amyloid protein (Abeta), either as extracellular amyloid plaques in the brain ..
- Early Detection of Cerebral Amyloid AngiopathySteven M Greenberg; Fiscal Year: 2010Deposition of ss-amyloid (Ass) in the cerebral vessels (cerebral amyloid angiopathy or CAA) is a major cause of hemorrhagic stroke, a contributor to vascular cognitive impairment, and a complicating factor in attempts to develop anti-..
- Roles of reticulon proteins in neurodegenerative diseasesRiqiang Yan; Fiscal Year: 2010..We demonstrated that increased expression of RTN3 in mice reduced amyloid deposition in cortical brain regions...
- Cholesterol and copper affect learning and memoryBERNARD SCHREURS; Fiscal Year: 2009..A high cholesterol diet has been shown to result in beta amyloid deposits - one the hallmarks of Alzheimer's disease...
- Structural Characterization of Amyloid Fibrils Using Deep UV Raman SpectroscopyIgor K Lednev; Fiscal Year: 2010b>Amyloid fibrils are associated with numerous debilitating diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, prion disease, familial amyloid polyneuropathy, senile systemic amyloidosis and ..
- Molecular mechanism of senile cardiac amyloidosisLawreen H Connors; Fiscal Year: 2010Cardiomyopathy in elderly men can be the result of extracellular deposits of amyloid in the heart, pathology referred to as Senile Systemic (or Cardiac) Amyloidosis (SSA)...
- METABOLISM OF SERUM AMYLOID A (SAA:HDL)Barbara Kluve Beckerman; Fiscal Year: 2007..arthritis and familial Mediterranean fever, and is characterized by extracellular fibrillar deposits of amyloid A (AA) protein, a peptide proteolytically derived from the acute phase reactant serum amyloid A (SAA)...
- Magnetic Resonance Imaging of Alzheimer's Amyloid PlaqueJOSEPH PODUSLO; Fiscal Year: 2007This project will test the hypothesis that modifications of amyloid-beta protein (A beta) or derivatives of A beta can be used for the molecular imaging of amyloid plaques in Alzheimer's disease (AD)...
- TRANSGENIC MICE, INFLAMMATION & THE ALZHEIMER PHENOTYPEMarcia N Gordon; Fiscal Year: 2010..Reducing brain amyloid and its consequences is a therapeutic strategy in active development...
- Investigation of the yeast prion factor [PSI+]Susan W Liebman; Fiscal Year: 2010The misfolding of different cellular proteins into amyloid-like aggregates is associated with non- infectious neurodegenerative diseases including Alzheimer's, Huntington's and Parkinson's, as well as with the infectious ..
- Inhibitors of beta-Amyloid Production in Alzheimer'sGregory Hook; Fiscal Year: 2007..Abnormal accumulation of extracellular brain beta-amyloid is thought to cause AD and compounds that block beta-amyloid production are predicted to be effective for ..
- Amyloid-Lowering Small Molecule AB-Binding Agents in ADWilliam Klunk; Fiscal Year: 2007..Because of the key role of the amyloid-beta (A?) peptide in the pathophysiology of AD, A? synthesis, deposition and clearance have become important ..
- Loss of synapses in physiological and pathological agingPascale Lacor; Fiscal Year: 2003..Alzheimer's disease (AD) is a neurodegenerative disorder that is pathologically characterized by the presence of amyloid deposits composed by filaments of amyloid beta (Abeta) peptide...
- Lipoate Derivatives Targeting Alzheimer's AmyloidXudong Huang; Fiscal Year: 2007..Moreover, the exact subserving mechanism(s) of antioxidant/metal chelation effects upon AD amyloid pathology are not clear...
- Untangling Amyloid Plaques With ProteasesJin Moo Lee; Fiscal Year: 2010..A?1-42, the 42 amino-acid peptide fragment of the amyloid precursor protein (APP), has a striking propensity to aggregate into amyloid fibrils within plaques...
- Untangling Amyloid Plaques With ProteasesJin Moo Lee; Fiscal Year: 2009..A?1-42, the 42 amino-acid peptide fragment of the amyloid precursor protein (APP), has a striking propensity to aggregate into amyloid fibrils within plaques...
- Structure and conformational diversity of amyloid oligomersCharles G Glabe; Fiscal Year: 2010The goal of this research project is to explore the structural heterogeneity of amyloid aggregates and the relationships of this conformational variation to the toxicity or pathogenic activities of amyloid oligomers...