amyloid

Summary

Summary: A type of extracellularly deposited substance composed of an amyloid protein and additional components including HEPARAN SULFATE PROTEOGLYCAN; LAMININ; COLLAGEN TYPE IV; SERUM AMYLOID P-COMPONENT; and APOLIPOPROTEINS E which together form characteristic amyloid fibrils. The core of amyloid fibrils is formed by the stacking of overlapping beta-pleated sheet domains of the amyloid protein. There are many different amyloid proteins that have been found forming the core of the fibrils in vivo. However, amyloid can be formed from any protein that exposes beta-pleated strand conformations during unfolding or refolding. A common characteristic of amyloid is the ability to bind such dyes as CONGO RED and thioflavine.

Top Publications

  1. ncbi Protein misfolding, functional amyloid, and human disease
    Fabrizio Chiti
    Dipartimento di Scienze Biochimiche, Universita degli Studi di Firenze, I 50134 Firenze, Italy
    Annu Rev Biochem 75:333-66. 2006
  2. ncbi Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    William E Klunk
    Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Ann Neurol 55:306-19. 2004
  3. ncbi Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    Alexandra E Butler
    Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Diabetes 52:102-10. 2003
  4. pmc Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Nat Immunol 11:897-904. 2010
  5. ncbi Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory
    Randy L Buckner
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63105, USA
    J Neurosci 25:7709-17. 2005
  6. pmc Amyloid plaque core protein in Alzheimer disease and Down syndrome
    C L Masters
    Proc Natl Acad Sci U S A 82:4245-9. 1985
  7. ncbi Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Science 300:486-9. 2003
  8. ncbi Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease
    Hiroaki Fukumoto
    Alzheimer Disease Research Unit, Center for Aging, Genetics, and Neurodegeneration, Massachusetts General Hospital East, Bldg 114, Room 2010, 114 16th Street, Charlestown, MA 02129, USA
    Arch Neurol 59:1381-9. 2002
  9. doi Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions
    Heidi Olzscha
    Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Martinsried, Germany
    Cell 144:67-78. 2011
  10. pmc Identifying the amylome, proteins capable of forming amyloid-like fibrils
    Lukasz Goldschmidt
    Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095 1570, USA
    Proc Natl Acad Sci U S A 107:3487-92. 2010

Detail Information

Publications332 found, 100 shown here

  1. ncbi Protein misfolding, functional amyloid, and human disease
    Fabrizio Chiti
    Dipartimento di Scienze Biochimiche, Universita degli Studi di Firenze, I 50134 Firenze, Italy
    Annu Rev Biochem 75:333-66. 2006
    ..We review recent advances toward the elucidation of the structures of amyloid fibrils and the mechanisms of their formation at a molecular level...
  2. ncbi Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    William E Klunk
    Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Ann Neurol 55:306-19. 2004
    This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls...
  3. ncbi Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    Alexandra E Butler
    Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Diabetes 52:102-10. 2003
    ....
  4. pmc Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Nat Immunol 11:897-904. 2010
    ..Here we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid deposits in the pancreas during type 2 diabetes, triggered the ..
  5. ncbi Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory
    Randy L Buckner
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63105, USA
    J Neurosci 25:7709-17. 2005
    Alzheimer's disease (AD) and antecedent factors associated with AD were explored using amyloid imaging and unbiased measures of longitudinal atrophy in combination with reanalysis of previous metabolic and functional studies...
  6. pmc Amyloid plaque core protein in Alzheimer disease and Down syndrome
    C L Masters
    Proc Natl Acad Sci U S A 82:4245-9. 1985
    We have purified and characterized the cerebral amyloid protein that forms the plaque core in Alzheimer disease and in aged individuals with Down syndrome...
  7. ncbi Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Science 300:486-9. 2003
    ..Soluble oligomers have a unique distribution in human AD brain that is distinct from fibrillar amyloid. These results indicate that different types of soluble amyloid oligomers have a common structure and suggest ..
  8. ncbi Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease
    Hiroaki Fukumoto
    Alzheimer Disease Research Unit, Center for Aging, Genetics, and Neurodegeneration, Massachusetts General Hospital East, Bldg 114, Room 2010, 114 16th Street, Charlestown, MA 02129, USA
    Arch Neurol 59:1381-9. 2002
    b>Amyloid plaques, a major pathological feature of Alzheimer disease (AD), are composed of an internal fragment of amyloid precursor protein (APP): the 4-kd amyloid-beta protein (Abeta)...
  9. doi Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions
    Heidi Olzscha
    Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Martinsried, Germany
    Cell 144:67-78. 2011
    ..Here, we have analyzed the gain-of-function toxicity of artificial β sheet proteins that were designed to form amyloid-like fibrils...
  10. pmc Identifying the amylome, proteins capable of forming amyloid-like fibrils
    Lukasz Goldschmidt
    Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095 1570, USA
    Proc Natl Acad Sci U S A 107:3487-92. 2010
    The amylome is the universe of proteins that are capable of forming amyloid-like fibrils. Here we investigate the factors that enable a protein to belong to the amylome...
  11. doi Islet amyloid polypeptide, islet amyloid, and diabetes mellitus
    Per Westermark
    Department of Medical Cell Biology and Immunology, Uppsala University, Uppsala, Sweden
    Physiol Rev 91:795-826. 2011
    Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of the pancreatic islets of Langerhans...
  12. doi Atomic view of a toxic amyloid small oligomer
    Arthur Laganowsky
    Department of Biological Chemistry, University of California Los Angeles UCLA, Howard Hughes Medical Institute HHMI, Los Angeles, CA 90095, USA
    Science 335:1228-31. 2012
    b>Amyloid diseases, including Alzheimer's, Parkinson's, and the prion conditions, are each associated with a particular protein in fibrillar form...
  13. pmc A systematic survey identifies prions and illuminates sequence features of prionogenic proteins
    Simon Alberti
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 137:146-58. 2009
    ..The self-perpetuating states of these proteins present a vast source of heritable phenotypic variation that increases the adaptability of yeast populations to diverse environments...
  14. pmc Amyloid precursor protein trafficking, processing, and function
    Gopal Thinakaran
    Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 283:29615-9. 2008
    Intracellular trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations over the past two decades...
  15. ncbi Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    G G Glenner
    Biochem Biophys Res Commun 120:885-90. 1984
    ..This protein may be derived from a unique serum precursor which may provide a diagnostic test for Alzheimer's disease and a means to understand its pathogenesis...
  16. pmc Functional amyloids as natural storage of peptide hormones in pituitary secretory granules
    Samir K Maji
    Laboratory of Physical Chemistry, Eidgenossische Technische Hochschule ETH Zurich, Wolfgang Paulistrasse 10, CH 8093 Zurich, Switzerland
    Science 325:328-32. 2009
    ..a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation...
  17. ncbi The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    J Kang
    Nature 325:733-6. 1987
    Alzheimer's disease is characterized by a widespread functional disturbance of the human brain. Fibrillar amyloid proteins are deposited inside neurons as neurofibrillary tangles and extracellularly as amyloid plaque cores and in blood ..
  18. ncbi The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    G P Lim
    Departments of Medicine and Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 21:8370-7. 2001
    ..With low-dose but not high-dose curcumin treatment, the astrocytic marker GFAP was reduced, and insoluble beta-amyloid (Abeta), soluble Abeta, and plaque burden were significantly decreased by 43-50%...
  19. pmc Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    Jia Yao
    Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 106:14670-5. 2009
    ..Mitochondrial amyloid beta (Abeta) level in the 3xTg-AD mice was significantly increased at 9 months and temporally correlated with ..
  20. ncbi Functional amyloid--from bacteria to humans
    Douglas M Fowler
    Department of Chemistry and The Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Biochem Sci 32:217-24. 2007
    b>Amyloid--a fibrillar, cross beta-sheet quaternary structure--was first discovered in the context of human disease and tissue damage, and was thought to always be detrimental to the host...
  21. pmc In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18)
    Dean F Wong
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0807, USA
    J Nucl Med 51:913-20. 2010
    An (18)F-labeled PET amyloid-beta (Abeta) imaging agent could facilitate the clinical evaluation of late-life cognitive impairment by providing an objective measure for Alzheimer disease (AD) pathology...
  22. ncbi Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
    M A Chishti
    Centre for Research in Neurodegenerative Diseases, The Department of Laboratory Medicine, Division of Neurology, University Health Network, University of Toronto, Toronto, Ontario M5S 3H2, Canada
    J Biol Chem 276:21562-70. 2001
    ..transgenic (Tg) models by exploiting the synergistic effects of familial Alzheimer's disease mutations on amyloid beta-peptide (Abeta) biogenesis...
  23. pmc Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
    Silvestre Alavez
    Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, California 94945, USA
    Nature 472:226-9. 2011
    ..A group of small molecules, traditionally used in histopathology to stain amyloid in tissues, bind protein fibrils and slow aggregation in vitro and in cell culture...
  24. doi The transcellular spread of cytosolic amyloids, prions, and prionoids
    Adriano Aguzzi
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Neuron 64:783-90. 2009
    ....
  25. pmc Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease
    Kaan E Biron
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 6:e23789. 2011
    ..Cerebrovascular integrity was characterized in Tg2576 AD model mice that overexpress the human amyloid precursor protein (APP) containing the double missense mutations, APPsw, found in a Swedish family, that causes ..
  26. ncbi Mechanism of amyloidogenesis: nucleation-dependent fibrillation versus double-concerted fibrillation
    Ghibom Bhak
    School of Chemical and Biological Engineering, College of Engineering, Seoul National University, Seoul, Korea
    BMB Rep 42:541-51. 2009
    ..defines a condition in which a soluble and innocuous protein turns to insoluble protein aggregates known as amyloid fibrils...
  27. doi Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
    Stuart A Sievers
    Department of Biological Chemistry, Howard Hughes Medical Institute, UCLA, Box 951970, Los Angeles, California 90095 1570, USA
    Nature 475:96-100. 2011
    Many globular and natively disordered proteins can convert into amyloid fibrils. These fibrils are associated with numerous pathologies as well as with normal cellular functions, and frequently form during protein denaturation...
  28. pmc Prion-like transmission of protein aggregates in neurodegenerative diseases
    Patrik Brundin
    Patrik Brundin is at the Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, BMC A10, 221 84 Lund, Sweden
    Nat Rev Mol Cell Biol 11:301-7. 2010
    ..The transfer of naked infectious particles between cells could therefore be a target for new disease-modifying therapies...
  29. pmc Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance
    Tristan Bolmont
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
    J Neurosci 28:4283-92. 2008
    Microglial cells aggregate around amyloid plaques in Alzheimer's disease, but, despite their therapeutic potential, various aspects of their reactive kinetics and role in plaque pathogenesis remain hypothetical...
  30. doi An analytical solution to the kinetics of breakable filament assembly
    Tuomas P J Knowles
    Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge CB3 0HE, UK
    Science 326:1533-7. 2009
    ..Application to the case of protein aggregation demonstrates that the kinetics of amyloid growth can often be dominated by secondary rather than by primary nucleation events...
  31. doi Exploring the sequence determinants of amyloid structure using position-specific scoring matrices
    Sebastian Maurer-Stroh
    VIB Switch Laboratory, Flanders Institute for Biotechnology and Vrije Universiteit Brussel, Brussels, Belgium
    Nat Methods 7:237-42. 2010
    ..results in beta-sheet-like assemblies that adopt either a variety of amorphous morphologies or ordered amyloid-like structures...
  32. doi Biology of amyloid: structure, function, and regulation
    Jason Greenwald
    ETH Zurich, Physical Chemistry, ETH Honggerberg, 8093 Zurich, Switzerland
    Structure 18:1244-60. 2010
    ..It grows by recruitment of the corresponding amyloid protein, while its repetitiveness can translate what would be a nonspecific activity as monomer into a potent one ..
  33. pmc 3D structure of Alzheimer's amyloid-beta(1-42) fibrils
    Thorsten Luhrs
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:17342-7. 2005
    Alzheimer's disease is the most fatal neurodegenerative disorder wherein the process of amyloid-beta (Abeta) amyloidogenesis appears causative...
  34. doi Critical role of amyloid-like oligomers of Drosophila Orb2 in the persistence of memory
    Amitabha Majumdar
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Cell 148:515-29. 2012
    ..Here, we found that the Drosophila CPEB Orb2 forms amyloid-like oligomers, and oligomers are enriched in the synaptic membrane fraction...
  35. doi EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
    Dagmar E Ehrnhoefer
    Max Delbrueck Center for Molecular Medicine, AG Neuroproteomics, 13092 Berlin, Germany
    Nat Struct Mol Biol 15:558-66. 2008
    The accumulation of beta-sheet-rich amyloid fibrils or aggregates is a complex, multistep process that is associated with cellular toxicity in a number of human protein misfolding disorders, including Parkinson's and Alzheimer's diseases...
  36. ncbi The PASTA server for protein aggregation prediction
    Antonio Trovato
    Department of Physics G Galilei, University of Padova, Padova, Italy
    Protein Eng Des Sel 20:521-3. 2007
    Many different proteins aggregate into amyloid fibrils characterized by cross-beta structure. beta-strands contributed by distinct protein molecules are generally found in a parallel in-register alignment...
  37. pmc Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins
    Randal Halfmann
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Mol Cell 43:72-84. 2011
    ..A systematic survey of prion-forming domains suggested that Q and N residues have distinct effects on amyloid formation...
  38. pmc Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation
    Lynette Cegelski
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Chem Biol 5:913-9. 2009
    Curli are functional extracellular amyloid fibers produced by uropathogenic Escherichia coli (UPEC) and other Enterobacteriaceae...
  39. ncbi Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 59:512-9. 2006
    b>Amyloid-beta(42) (Abeta(42)) appears central to Alzheimer's disease (AD) pathogenesis and is a major component of amyloid plaques. Mean cerebrospinal fluid (CSF) Abeta(42) is decreased in dementia of the Alzheimer's type...
  40. pmc Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    J Biol Chem 284:4230-7. 2009
    b>Amyloid oligomers are believed to play causal roles in several types of amyloid-related neurodegenerative diseases...
  41. ncbi A toxic monomeric conformer of the polyglutamine protein
    Yoshitaka Nagai
    Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Nat Struct Mol Biol 14:332-40. 2007
    ..conformational transition of the expanded polyQ protein monomer precedes its assembly into beta-sheet-rich amyloid-like fibrils...
  42. ncbi A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model
    Giselle P Lim
    Department of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 25:3032-40. 2005
    ..are unknown, we used the APPsw (Tg2576) transgenic mouse model to evaluate the impact of dietary DHA on amyloid precursor protein (APP) processing and amyloid burden...
  43. pmc Functional amyloid formation within mammalian tissue
    Douglas M Fowler
    Department of Chemistry, The Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, California, USA
    PLoS Biol 4:e6. 2006
    b>Amyloid is a generally insoluble, fibrous cross-beta sheet protein aggregate. The process of amyloidogenesis is associated with a variety of neurodegenerative diseases including Alzheimer, Parkinson, and Huntington disease...
  44. pmc Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008
    To characterize the prevalence of amyloid deposition in a clinically unimpaired elderly population, as assessed by Pittsburgh Compound B (PiB) positron emission tomography (PET) imaging, and its relationship to cognitive function, ..
  45. ncbi Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct
    Mihaela Necula
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    J Biol Chem 282:10311-24. 2007
    Alzheimer disease is characterized by the abnormal aggregation of amyloid beta peptide into extracellular fibrillar deposits known as amyloid plaques...
  46. pmc Highly efficient protein misfolding cyclic amplification
    Nuria Gonzalez-Montalban
    Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, Maryland, United States of America
    PLoS Pathog 7:e1001277. 2011
    ..The new PMCAb format offers immediate practical benefits and opens new avenues for developing fast ultrasensitive assays and for producing abundant quantities of PrP(Sc)in vitro...
  47. pmc Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β
    Justin M Nussbaum
    Department of Biology, University of Virginia, Charlottesville, Virginia 22904, USA
    Nature 485:651-5. 2012
    Extracellular plaques of amyloid-β and intraneuronal neurofibrillary tangles made from tau are the histopathological signatures of Alzheimer's disease...
  48. doi The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide
    Priyanka Narayan
    Department of Chemistry, University of Cambridge, Cambridge, UK
    Nat Struct Mol Biol 19:79-83. 2012
    ..We have examined the interactions between human clusterin and the Alzheimer's disease-associated amyloid-β(1-40) peptide (Aβ(1-40)), which is prone to aggregate into an ensemble of oligomeric intermediates implicated ..
  49. ncbi Lipid membranes modulate the structure of islet amyloid polypeptide
    Sajith A Jayasinghe
    Department of Biochemistry and Molecular Biology, Zilkha Neurogenetic Institute, University of Southern California, 1501 San Pablo Street, Los Angeles, California 90033, USA
    Biochemistry 44:12113-9. 2005
    The 37-residue islet amyloid polypeptide (IAPP) is thought to play an important role in the pathogenesis of type II diabetes...
  50. pmc Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits
    Robert Tamayev
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:20822-7. 2010
    According to the prevailing "amyloid cascade hypothesis," genetic dementias such as Alzheimer's disease and familial Danish dementia (FDD) are caused by amyloid deposits that trigger tauopathy, neurodegeneration, and behavioral/cognitive ..
  51. pmc Amyloid fibers provide structural integrity to Bacillus subtilis biofilms
    Diego Romero
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:2230-4. 2010
    ..analyses, in combination with the use of specific dyes and microscopic analyses, indicate that TasA forms amyloid fibers. Consistent with this hypothesis, TasA fibers required harsh treatments (e.g...
  52. doi Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis
    Jean D Sipe
    Department of Biochemistry Emerita, Boston University School of Medicine, Boston, MA 02118, USA
    Amyloid 17:101-4. 2010
    A system of amyloid fibril nomenclature based on the chemical identity of the amyloid fibril forming protein is recommended...
  53. doi Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core
    Christian Wasmer
    Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland
    Science 319:1523-6. 2008
    ..We present a structural model based on solid-state nuclear magnetic resonance restraints for amyloid fibrils from the prion-forming domain (residues 218 to 289) of the HET-s protein from the filamentous fungus ..
  54. ncbi Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
    D R Borchelt
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 19:939-45. 1997
    ..of experimental in vitro and in vivo settings, FAD-linked presenilin variants influence the processing of the amyloid precursor protein (APP), leading to elevated levels of the highly fibrillogenic Abeta1-42 peptides that are ..
  55. pmc Amyloid ion channels: a common structural link for protein-misfolding disease
    Arjan Quist
    Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 102:10427-32. 2005
    ..and Parkinson's diseases, result from protein misfolding, giving a distinct fibrillar feature termed amyloid. Recent studies show that only the globular (not fibrillar) conformation of amyloid proteins is sufficient to ..
  56. pmc ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice
    James J Donkin
    Department of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    J Biol Chem 285:34144-54. 2010
    ..In amyloid mouse models of AD, ABCA1 deficiency exacerbates amyloidogenesis, whereas ABCA1 overexpression ameliorates ..
  57. doi FoldAmyloid: a method of prediction of amyloidogenic regions from protein sequence
    Sergiy O Garbuzynskiy
    Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia
    Bioinformatics 26:326-32. 2010
    Amyloidogenic regions in polypeptide chains are very important because such regions are responsible for amyloid formation and aggregation. It is useful to be able to predict positions of amyloidogenic regions in protein chains.
  58. ncbi The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease
    Veronica Hirsch-Reinshagen
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V4Z 5H5, Canada
    J Biol Chem 280:43243-56. 2005
    ..In addition, ABCA1 has been reported to modulate beta-amyloid (Abeta) production in vitro...
  59. pmc Amyloid imaging in mild cognitive impairment subtypes
    David A Wolk
    Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 19104, USA
    Ann Neurol 65:557-68. 2009
    We utilized the amyloid imaging ligand Pittsburgh Compound B (PiB) to determine the presence of Alzheimer's disease (AD) pathology in different mild cognitive impairment (MCI) subtypes and to relate increased PiB binding to other markers ..
  60. pmc Fibril fragmentation enhances amyloid cytotoxicity
    Wei Feng Xue
    Astbury Centre for Structural Molecular Biology, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 284:34272-82. 2009
    Fibrils associated with amyloid disease are molecular assemblies of key biological importance, yet how cells respond to the presence of amyloid remains unclear...
  61. doi A diversity of assembly mechanisms of a generic amyloid fold
    Timo Eichner
    Astbury Centre for Structural Molecular Biology and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK
    Mol Cell 43:8-18. 2011
    Protein misfolding and amyloid assembly have long been recognized as being responsible for many devastating human diseases...
  62. pmc Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
    K Ueda
    Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla 92093 0624
    Proc Natl Acad Sci U S A 90:11282-6. 1993
    A neuropathological hallmark of Alzheimer disease (AD) is a widespread amyloid deposition...
  63. doi Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?
    Natalia N Nalivaeva
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
    J Neurochem 120:167-85. 2012
    The amyloid cascade hypothesis of Alzheimer's disease envisages that the initial elevation of amyloid β-peptide (Aβ) levels, especially of Aβ(1-42) , is the primary trigger for the neuronal cell death specific to onset of Alzheimer'..
  64. doi Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils
    Jan Bieschke
    Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Nat Chem Biol 8:93-101. 2012
    Several lines of evidence indicate that prefibrillar assemblies of amyloid-β (Aβ) polypeptides, such as soluble oligomers or protofibrils, rather than mature, end-stage amyloid fibrils cause neuronal dysfunction and memory impairment ..
  65. ncbi Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice
    Chad A Dickey
    Alzheimer s Disease Research Laboratory, Department of Pharmacology, University of South Florida, College of Medicine, Tampa, Florida 33612, USA
    J Neurosci 23:5219-26. 2003
    A critical question in Alzheimer's disease (AD) research is the cause of memory loss that leads to dementia. The amyloid precursor protein + presenilin-1 (APP+PS1) transgenic mouse is a model for amyloid deposition, and like AD, the mice ..
  66. pmc Antimicrobial properties of amyloid peptides
    Bruce L Kagan
    Department of Psychiatry, David Geffen School of Medicine, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90024, USA
    Mol Pharm 9:708-17. 2012
    More than two dozen clinical syndromes known as amyloid diseases are characterized by the buildup of extended insoluble fibrillar deposits in tissues...
  67. pmc Diversity, biogenesis and function of microbial amyloids
    Luz P Blanco
    Department of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Trends Microbiol 20:66-73. 2012
    b>Amyloid is a distinct β-sheet-rich fold that many proteins can acquire...
  68. ncbi Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice
    Radosveta Koldamova
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 280:43224-35. 2005
    ..To determine further the effect of ABCA1 on amyloid deposition, we used APP23 transgenic mice in which the human familial Swedish AD mutant is expressed only in ..
  69. pmc The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity
    Fanling Meng
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794 3400, USA
    Biochemistry 49:8127-33. 2010
    Islet amyloid polypeptide (IAPP, amylin) is the major protein component of the islet amyloid deposits associated with type 2 diabetes...
  70. pmc Bovine insulin filaments induced by reducing disulfide bonds show a different morphology, secondary structure, and cell toxicity from intact insulin amyloid fibrils
    Tamotsu Zako
    Bioengineering Laboratory, RIKEN Institute, Saitama, Japan
    Biophys J 96:3331-40. 2009
    b>Amyloid fibrils are associated with more than 20 diseases, including Alzheimer's disease and type II diabetes...
  71. ncbi Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology
    Christa J Maynard
    Department of Pathology, The University of Melbourne, VIC 3010, Australia
    J Inorg Biochem 100:952-62. 2006
    The incidence of Alzheimer's disease (AD) is greater in women than men at any age, as is the development of amyloid pathology in several transgenic mouse models of AD...
  72. pmc Scrambled prion domains form prions and amyloid
    Eric D Ross
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0830, USA
    Mol Cell Biol 24:7206-13. 2004
    The [URE3] prion of Saccharomyces cerevisiae is a self-propagating amyloid form of Ure2p. The amino-terminal prion domain of Ure2p is necessary and sufficient for prion formation and has a high glutamine (Q) and asparagine (N) content...
  73. doi Disease-associated amyloid and misfolded protein aggregates activate the inflammasome
    Seth L Masters
    Immunology Research Centre, Inflammation Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Trends Mol Med 17:276-82. 2011
    ..This review discusses the basic research behind these findings and the potential for new therapeutic interventions this affords...
  74. doi Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
    Paul Edison
    MRC Clinical Sciences Centre, Cyclotron Building Hammersmith Hospital, Imperial College London, UK
    Neurobiol Dis 32:412-9. 2008
    11C](R)PK11195-PET is a marker of activated microglia while [11C]PIB-PET detects raised amyloid load...
  75. pmc Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection
    Nadia R Roan
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA
    Cell Host Microbe 10:541-50. 2011
    ..Here, we report that a subset of these semenogelin fragments form amyloid fibrils that greatly enhance HIV infection...
  76. pmc Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfolding
    Zheng Zhou
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    J Biol Chem 284:30148-58. 2009
    ..3) Macromolecular crowding dramatically accelerates amyloid formation by human prion protein...
  77. pmc Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering
    Anders Sandberg
    Institute of Biomedicine, University of Gothenburg, SE 405 30 Gothenburg, Sweden
    Proc Natl Acad Sci U S A 107:15595-600. 2010
    Soluble oligomeric aggregates of the amyloid-beta peptide (Abeta) have been implicated in the pathogenesis of Alzheimer's disease (AD)...
  78. pmc Molecular mechanism of Thioflavin-T binding to amyloid fibrils
    Matthew Biancalana
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1804:1405-12. 2010
    Intense efforts to detect, diagnose, and analyze the kinetic and structural properties of amyloid fibrils have generated a powerful toolkit of amyloid-specific molecular probes...
  79. pmc The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals
    Bradford C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Cereb Cortex 19:497-510. 2009
    ..Furthermore, subtle thinning is present in asymptomatic older controls with brain amyloid binding as detected with amyloid imaging...
  80. pmc Two amyloid States of the prion protein display significantly different folding patterns
    Valeriy G Ostapchenko
    Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, MD 21201, USA
    J Mol Biol 400:908-21. 2010
    It has been well established that a single amino acid sequence can give rise to several conformationally distinct amyloid states...
  81. pmc Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway
    Tatyana Gurlo
    Larry Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 7073, USA
    Am J Pathol 176:861-9. 2010
    The islet in type 2 diabetes mellitus (T2DM) is characterized by a deficit in beta cells and islet amyloid derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by beta cells...
  82. ncbi Amyloid peptide channels
    B L Kagan
    Department of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine, UCLA, Los Angeles, California 90024 1759, USA
    J Membr Biol 202:1-10. 2004
    ..prion diseases), are characterized by the deposition of amorphous, Congo red-staining deposits known as amyloid. These "misfolded" proteins adopt beta-sheet structures and aggregate spontaneously into similar extended fibrils ..
  83. pmc Stacked sets of parallel, in-register beta-strands of beta2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labeling
    Carol L Ladner
    Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 285:17137-47. 2010
    beta(2)-microglobulin (beta(2)m) is a 99-residue protein with an immunoglobulin fold that forms beta-sheet-rich amyloid fibrils in dialysis-related amyloidosis...
  84. ncbi Conformational variations in an infectious protein determine prion strain differences
    Motomasa Tanaka
    Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94143, USA
    Nature 428:323-8. 2004
    ..Infection of yeast with these different amyloid conformations leads to different [PSI+] strains...
  85. pmc Molecular basis for insulin fibril assembly
    Magdalena I Ivanova
    Howard Hughes Medical Institute, UCLA DOE Institute for Genomics and Proteomics, Los Angeles CA 90095 1570, USA
    Proc Natl Acad Sci U S A 106:18990-5. 2009
    ..into pairs of tightly interdigitated beta-sheets, each pair displaying the dry steric zipper interface typical of amyloid-like fibrils...
  86. pmc Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis
    Leena Haataja
    Larry Hillblom Islet Research Center, UCLA David Geffen School of Medicine, 900 Weyburn Place A, Los Angeles, California 90024 2852, USA
    Endocr Rev 29:303-16. 2008
    ..resistance, defective insulin secretion, loss of beta-cell mass with increased beta-cell apoptosis and islet amyloid. The islet amyloid is derived from islet amyloid polypeptide (IAPP, amylin), a protein coexpressed and cosecreted ..
  87. ncbi Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition
    Donna M Wilcock
    Alzheimer s Research Laboratory, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci 24:6144-51. 2004
    The role of microglia in the removal of amyloid deposits after systemically administered anti-Abeta antibodies remains unclear...
  88. ncbi Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation
    Liming Hou
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 7078, USA
    J Am Chem Soc 126:1992-2005. 2004
    ..by the aggregation and fibrillation of the 40-residue A beta(1-40) and 42-residue A beta(1-42) peptides into amyloid plaques...
  89. ncbi In vitro conversion of full-length mammalian prion protein produces amyloid form with physical properties of PrP(Sc)
    Olga V Bocharova
    Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    J Mol Biol 346:645-59. 2005
    ..that the infectious agent of prion diseases, PrP(Sc), is composed of the prion protein (PrP) converted into an amyloid-specific conformation...
  90. ncbi Techniques to study amyloid fibril formation in vitro
    Melanie R Nilsson
    Department of Chemistry, McDaniel College, Eaton Hall, 2 College Hill, Westminster, MD 21157, USA
    Methods 34:151-60. 2004
    b>Amyloid fibrils are ordered aggregates of peptides or proteins that are fibrillar in structure and contribute to the complications of many diseases (e.g., type 2 diabetes mellitus, Alzheimer's disease, and primary systemic amyloidosis)...
  91. pmc Amyloid beta protein: Abeta40 inhibits Abeta42 oligomerization
    Megan M Murray
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106 950, USA
    J Am Chem Soc 131:6316-7. 2009
    ..Abeta42, however, is significantly more neurotoxic than Abeta40 and forms amyloid fibrils much more rapidly than Abeta40...
  92. doi Amyloid efflux transporter expression at the blood-brain barrier declines in normal aging
    Gerald D Silverberg
    Department of Neurosurgery, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
    J Neuropathol Exp Neurol 69:1034-43. 2010
    Reduced clearance of amyloid β peptides (Aβ) across the blood-brain barrier contributes to amyloid accumulation in Alzheimer disease...
  93. pmc Magic angle spinning NMR analysis of beta2-microglobulin amyloid fibrils in two distinct morphologies
    Galia T Debelouchina
    Department of Chemistry and Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 132:10414-23. 2010
    Beta(2)-microglobulin (beta(2)m) is the major structural component of amyloid fibrils deposited in a condition known as dialysis-related amyloidosis...
  94. pmc Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    EMBO Mol Med 1:371-80. 2009
    ..We previously reported that cerebrospinal fluid (CSF) levels of amyloid-beta(42) (Abeta(42)) serve as an excellent marker for brain amyloid as detected by the amyloid tracer, Pittsburgh ..
  95. doi Cytosolic accumulation of HPV16 E7 oligomers supports different transformation routes for the prototypic viral oncoprotein: the amyloid-cancer connection
    Karina Dantur
    Instituto Leloir and Instituto de Investigaciones Bioquímicas Buenos Aires, CONICET, Patricias Argentinas 435, C1405BWE Ciudad Autonoma de Buenos Aires, Argentina
    Int J Cancer 125:1902-11. 2009
    ..The protein can form spherical oligomers with amyloid-like properties and chaperone activity...
  96. doi The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compounds
    Sean A Hudson
    School of Chemistry and Physics, The University of Adelaide, Australia
    FEBS J 276:5960-72. 2009
    Thioflavin T (ThT) dye fluorescence is used regularly to quantify the formation and inhibition of amyloid fibrils in the presence of anti-amyloidogenic compounds such as polyphenols...
  97. pmc Disruption of functional connectivity in clinically normal older adults harboring amyloid burden
    Trey Hedden
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Neurosci 29:12686-94. 2009
    b>Amyloid deposition is present in 20-50% of nondemented older adults yet the functional consequences remain unclear...
  98. pmc A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
    Rolf Postina
    Institute of Biochemistry, University of Mainz, Mainz, Germany
    J Clin Invest 113:1456-64. 2004
    Alzheimer disease (AD) is characterized by excessive deposition of amyloid beta-peptides (A beta peptides) in the brain...
  99. pmc Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy
    Gregory A Dierksen
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ann Neurol 68:545-8. 2010
    Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined...
  100. ncbi Amyloid deposits: protection against toxic protein species?
    Sebastian Treusch
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Cell Cycle 8:1668-74. 2009
    ..In several cases the intracellular and extracellular protein deposits contain a fibrillar protein species called amyloid. However while amyloid deposits are hallmarks of numerous neurodegenerative diseases, their actual role in ..
  101. pmc Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition
    Andrei G Vlassenko
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:17763-7. 2010
    b>Amyloid-β (Aβ) plaque deposition can precede the clinical manifestations of dementia of the Alzheimer type (DAT) by many years and can be associated with changes in brain metabolism...

Research Grants96

  1. Preclinical Diagnostic Imaging of Amyloid
    Jonathan S Wall; Fiscal Year: 2010
    b>Amyloid is associated with a diverse group of often fatal hereditary and sporadic protein misfolding disorders, characterized by the deposition of fibrils and heparan sulfate proteoglycan in vital organs and tissues...
  2. Implication of HUCBC: a novel therapeutic strategy for Alzheimer's disease
    Jun Tan; Fiscal Year: 2010
    ..this downregulation of neurotoxic innate responses and upregulation of salutary humoral responses, A levels/- amyloid deposits and cerebral amyloid angiopathy (CAA;an inflammatory response to vascular amyloid deposits) are reduced ..
  3. Implication of HUCBC: a novel therapeutic strategy for Alzheimer's disease
    Jun Tan; Fiscal Year: 2009
    ..this downregulation of neurotoxic innate responses and upregulation of salutary humoral responses, A levels/- amyloid deposits and cerebral amyloid angiopathy (CAA; an inflammatory response to vascular amyloid deposits) are reduced ..
  4. Preclinical Diagnostic Imaging of Amyloid
    Jonathan Wall; Fiscal Year: 2009
    b>Amyloid is associated with a diverse group of often fatal hereditary and sporadic protein misfolding disorders, characterized by the deposition of fibrils and heparan sulfate proteoglycan in vital organs and tissues...
  5. Mechanisms of Microglial Activation and Phagocytosis in*
    Gary Landreth; Fiscal Year: 2005
    Alzheimer's disease is characterized by the extensive deposition of fibrillar forms of beta-amyloid (AB) peptides into the extracellular space, and their compaction into senile plaques...
  6. Cholesterol and copper affect learning and memory
    BERNARD SCHREURS; Fiscal Year: 2007
    ..A high cholesterol diet has been shown to result in beta amyloid deposits - one the hallmarks of Alzheimer's disease...
  7. SOLUTION STRUCTURE OF THE AMYLOID BETA (1/42)
    Michael Zagorski; Fiscal Year: 1999
    DESCRIPTION The 42-residue, beta-(1-42) peptide is the predominant protein component of amyloid plaque core deposits in Alzheimer's disease (AD). The beta-(1-42) nucleates amyloid formation...
  8. Protein Amyloidogenesis in the Epididymis: Mechanisms and Biological Significance
    Gail Cornwall; Fiscal Year: 2009
    The long range objective of our studies is to determine the biological significance of amyloid-type protein aggregation and mechanisms for its control in the epididymal lumen using the cystatins as molecular models...
  9. Protein Amyloidogenesis in the Epididymis: Mechanisms and Biological Significance
    Gail Cornwall; Fiscal Year: 2010
    The long range objective of our studies is to determine the biological significance of amyloid-type protein aggregation and mechanisms for its control in the epididymal lumen using the cystatins as molecular models...
  10. Proteoglycans/Glycosaminoglycans in APP Transgenic Mice
    ALAN SNOW; Fiscal Year: 2004
    ..AD is characterized by the accumulation of insoluble fibrillar amyloid deposits containing the beta-amyloid protein (Abeta), either as extracellular amyloid plaques in the brain ..
  11. Early Detection of Cerebral Amyloid Angiopathy
    Steven M Greenberg; Fiscal Year: 2010
    Deposition of ss-amyloid (Ass) in the cerebral vessels (cerebral amyloid angiopathy or CAA) is a major cause of hemorrhagic stroke, a contributor to vascular cognitive impairment, and a complicating factor in attempts to develop anti-..
  12. Roles of reticulon proteins in neurodegenerative diseases
    Riqiang Yan; Fiscal Year: 2010
    ..We demonstrated that increased expression of RTN3 in mice reduced amyloid deposition in cortical brain regions...
  13. Cholesterol and copper affect learning and memory
    BERNARD SCHREURS; Fiscal Year: 2009
    ..A high cholesterol diet has been shown to result in beta amyloid deposits - one the hallmarks of Alzheimer's disease...
  14. Structural Characterization of Amyloid Fibrils Using Deep UV Raman Spectroscopy
    Igor K Lednev; Fiscal Year: 2010
    b>Amyloid fibrils are associated with numerous debilitating diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, prion disease, familial amyloid polyneuropathy, senile systemic amyloidosis and ..
  15. Molecular mechanism of senile cardiac amyloidosis
    Lawreen H Connors; Fiscal Year: 2010
    Cardiomyopathy in elderly men can be the result of extracellular deposits of amyloid in the heart, pathology referred to as Senile Systemic (or Cardiac) Amyloidosis (SSA)...
  16. METABOLISM OF SERUM AMYLOID A (SAA:HDL)
    Barbara Kluve Beckerman; Fiscal Year: 2007
    ..arthritis and familial Mediterranean fever, and is characterized by extracellular fibrillar deposits of amyloid A (AA) protein, a peptide proteolytically derived from the acute phase reactant serum amyloid A (SAA)...
  17. Magnetic Resonance Imaging of Alzheimer's Amyloid Plaque
    JOSEPH PODUSLO; Fiscal Year: 2007
    This project will test the hypothesis that modifications of amyloid-beta protein (A beta) or derivatives of A beta can be used for the molecular imaging of amyloid plaques in Alzheimer's disease (AD)...
  18. TRANSGENIC MICE, INFLAMMATION & THE ALZHEIMER PHENOTYPE
    Marcia N Gordon; Fiscal Year: 2010
    ..Reducing brain amyloid and its consequences is a therapeutic strategy in active development...
  19. Investigation of the yeast prion factor [PSI+]
    Susan W Liebman; Fiscal Year: 2010
    The misfolding of different cellular proteins into amyloid-like aggregates is associated with non- infectious neurodegenerative diseases including Alzheimer's, Huntington's and Parkinson's, as well as with the infectious ..
  20. Inhibitors of beta-Amyloid Production in Alzheimer's
    Gregory Hook; Fiscal Year: 2007
    ..Abnormal accumulation of extracellular brain beta-amyloid is thought to cause AD and compounds that block beta-amyloid production are predicted to be effective for ..
  21. Amyloid-Lowering Small Molecule AB-Binding Agents in AD
    William Klunk; Fiscal Year: 2007
    ..Because of the key role of the amyloid-beta (A?) peptide in the pathophysiology of AD, A? synthesis, deposition and clearance have become important ..
  22. Loss of synapses in physiological and pathological aging
    Pascale Lacor; Fiscal Year: 2003
    ..Alzheimer's disease (AD) is a neurodegenerative disorder that is pathologically characterized by the presence of amyloid deposits composed by filaments of amyloid beta (Abeta) peptide...
  23. Lipoate Derivatives Targeting Alzheimer's Amyloid
    Xudong Huang; Fiscal Year: 2007
    ..Moreover, the exact subserving mechanism(s) of antioxidant/metal chelation effects upon AD amyloid pathology are not clear...
  24. Untangling Amyloid Plaques With Proteases
    Jin Moo Lee; Fiscal Year: 2010
    ..A?1-42, the 42 amino-acid peptide fragment of the amyloid precursor protein (APP), has a striking propensity to aggregate into amyloid fibrils within plaques...
  25. Untangling Amyloid Plaques With Proteases
    Jin Moo Lee; Fiscal Year: 2009
    ..A?1-42, the 42 amino-acid peptide fragment of the amyloid precursor protein (APP), has a striking propensity to aggregate into amyloid fibrils within plaques...
  26. Structure and conformational diversity of amyloid oligomers
    Charles G Glabe; Fiscal Year: 2010
    The goal of this research project is to explore the structural heterogeneity of amyloid aggregates and the relationships of this conformational variation to the toxicity or pathogenic activities of amyloid oligomers...