amyloid

Summary

Summary: A type of extracellularly deposited substance composed of an amyloid protein and additional components including HEPARAN SULFATE PROTEOGLYCAN; LAMININ; COLLAGEN TYPE IV; SERUM AMYLOID P-COMPONENT; and APOLIPOPROTEINS E which together form characteristic amyloid fibrils. The core of amyloid fibrils is formed by the stacking of overlapping beta-pleated sheet domains of the amyloid protein. There are many different amyloid proteins that have been found forming the core of the fibrils in vivo. However, amyloid can be formed from any protein that exposes beta-pleated strand conformations during unfolding or refolding. A common characteristic of amyloid is the ability to bind such dyes as CONGO RED and thioflavine.

Top Publications

  1. ncbi Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Science 300:486-9. 2003
  2. ncbi Protein misfolding, functional amyloid, and human disease
    Fabrizio Chiti
    Dipartimento di Scienze Biochimiche, Universita degli Studi di Firenze, I 50134 Firenze, Italy
    Annu Rev Biochem 75:333-66. 2006
  3. ncbi Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    William E Klunk
    Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA
    Ann Neurol 55:306-19. 2004
  4. ncbi Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Nat Immunol 11:897-904. 2010
  5. ncbi Amyloid plaque core protein in Alzheimer disease and Down syndrome
    C L Masters
    Proc Natl Acad Sci U S A 82:4245-9. 1985
  6. ncbi Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    Alexandra E Butler
    Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Diabetes 52:102-10. 2003
  7. ncbi Identifying the amylome, proteins capable of forming amyloid-like fibrils
    Lukasz Goldschmidt
    Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095 1570, USA
    Proc Natl Acad Sci U S A 107:3487-92. 2010
  8. ncbi Amyloid precursor protein trafficking, processing, and function
    Gopal Thinakaran
    Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 283:29615-9. 2008
  9. ncbi Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    Jia Yao
    Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 106:14670-5. 2009
  10. ncbi In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18)
    Dean F Wong
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0807, USA
    J Nucl Med 51:913-20. 2010

Research Grants

  1. Preclinical Diagnostic Imaging of Amyloid
    Jonathan S Wall; Fiscal Year: 2010
  2. Implication of HUCBC: a novel therapeutic strategy for Alzheimer's disease
    Jun Tan; Fiscal Year: 2010
  3. Implication of HUCBC: a novel therapeutic strategy for Alzheimer's disease
    Jun Tan; Fiscal Year: 2009
  4. Preclinical Diagnostic Imaging of Amyloid
    Jonathan Wall; Fiscal Year: 2009
  5. Mechanisms of Microglial Activation and Phagocytosis in*
    Gary Landreth; Fiscal Year: 2005
  6. Cholesterol and copper affect learning and memory
    BERNARD SCHREURS; Fiscal Year: 2007
  7. SOLUTION STRUCTURE OF THE AMYLOID BETA (1/42)
    Michael Zagorski; Fiscal Year: 1999
  8. Protein Amyloidogenesis in the Epididymis: Mechanisms and Biological Significance
    Gail Cornwall; Fiscal Year: 2010
  9. Protein Amyloidogenesis in the Epididymis: Mechanisms and Biological Significance
    Gail Cornwall; Fiscal Year: 2009
  10. Early Detection of Cerebral Amyloid Angiopathy
    Steven M Greenberg; Fiscal Year: 2010

Detail Information

Publications295 found, 100 shown here

  1. ncbi Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Science 300:486-9. 2003
    ..Soluble oligomers have a unique distribution in human AD brain that is distinct from fibrillar amyloid. These results indicate that different types of soluble amyloid oligomers have a common structure and suggest ..
  2. ncbi Protein misfolding, functional amyloid, and human disease
    Fabrizio Chiti
    Dipartimento di Scienze Biochimiche, Universita degli Studi di Firenze, I 50134 Firenze, Italy
    Annu Rev Biochem 75:333-66. 2006
    ..We review recent advances toward the elucidation of the structures of amyloid fibrils and the mechanisms of their formation at a molecular level...
  3. ncbi Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    William E Klunk
    Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA
    Ann Neurol 55:306-19. 2004
    This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls...
  4. ncbi Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Nat Immunol 11:897-904. 2010
    ..Here we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid deposits in the pancreas during type 2 diabetes, triggered the ..
  5. ncbi Amyloid plaque core protein in Alzheimer disease and Down syndrome
    C L Masters
    Proc Natl Acad Sci U S A 82:4245-9. 1985
    We have purified and characterized the cerebral amyloid protein that forms the plaque core in Alzheimer disease and in aged individuals with Down syndrome...
  6. ncbi Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    Alexandra E Butler
    Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Diabetes 52:102-10. 2003
    ....
  7. ncbi Identifying the amylome, proteins capable of forming amyloid-like fibrils
    Lukasz Goldschmidt
    Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095 1570, USA
    Proc Natl Acad Sci U S A 107:3487-92. 2010
    The amylome is the universe of proteins that are capable of forming amyloid-like fibrils. Here we investigate the factors that enable a protein to belong to the amylome...
  8. ncbi Amyloid precursor protein trafficking, processing, and function
    Gopal Thinakaran
    Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 283:29615-9. 2008
    Intracellular trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations over the past two decades...
  9. ncbi Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    Jia Yao
    Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 106:14670-5. 2009
    ..Mitochondrial amyloid beta (Abeta) level in the 3xTg-AD mice was significantly increased at 9 months and temporally correlated with ..
  10. ncbi In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18)
    Dean F Wong
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0807, USA
    J Nucl Med 51:913-20. 2010
    An (18)F-labeled PET amyloid-beta (Abeta) imaging agent could facilitate the clinical evaluation of late-life cognitive impairment by providing an objective measure for Alzheimer disease (AD) pathology...
  11. ncbi The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    G P Lim
    Departments of Medicine and Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 21:8370-7. 2001
    ..With low-dose but not high-dose curcumin treatment, the astrocytic marker GFAP was reduced, and insoluble beta-amyloid (Abeta), soluble Abeta, and plaque burden were significantly decreased by 43-50%...
  12. ncbi Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory
    Randy L Buckner
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63105, USA
    J Neurosci 25:7709-17. 2005
    Alzheimer's disease (AD) and antecedent factors associated with AD were explored using amyloid imaging and unbiased measures of longitudinal atrophy in combination with reanalysis of previous metabolic and functional studies...
  13. ncbi Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis
    Jean D Sipe
    Department of Biochemistry Emerita, Boston University School of Medicine, Boston, MA 02118, USA
    Amyloid 17:101-4. 2010
    A system of amyloid fibril nomenclature based on the chemical identity of the amyloid fibril forming protein is recommended...
  14. ncbi Functional amyloids as natural storage of peptide hormones in pituitary secretory granules
    Samir K Maji
    Laboratory of Physical Chemistry, Eidgenossische Technische Hochschule ETH Zurich, Wolfgang Paulistrasse 10, CH 8093 Zurich, Switzerland
    Science 325:328-32. 2009
    ..a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation...
  15. ncbi 3D structure of Alzheimer's amyloid-beta(1-42) fibrils
    Thorsten Luhrs
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:17342-7. 2005
    Alzheimer's disease is the most fatal neurodegenerative disorder wherein the process of amyloid-beta (Abeta) amyloidogenesis appears causative...
  16. ncbi Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation
    Lynette Cegelski
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Chem Biol 5:913-9. 2009
    Curli are functional extracellular amyloid fibers produced by uropathogenic Escherichia coli (UPEC) and other Enterobacteriaceae...
  17. ncbi Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions
    Heidi Olzscha
    Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Martinsried, Germany
    Cell 144:67-78. 2011
    ..Here, we have analyzed the gain-of-function toxicity of artificial β sheet proteins that were designed to form amyloid-like fibrils...
  18. ncbi Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 59:512-9. 2006
    b>Amyloid-beta(42) (Abeta(42)) appears central to Alzheimer's disease (AD) pathogenesis and is a major component of amyloid plaques. Mean cerebrospinal fluid (CSF) Abeta(42) is decreased in dementia of the Alzheimer's type...
  19. ncbi A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model
    Giselle P Lim
    Department of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 25:3032-40. 2005
    ..are unknown, we used the APPsw (Tg2576) transgenic mouse model to evaluate the impact of dietary DHA on amyloid precursor protein (APP) processing and amyloid burden...
  20. ncbi An analytical solution to the kinetics of breakable filament assembly
    Tuomas P J Knowles
    Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge CB3 0HE, UK
    Science 326:1533-7. 2009
    ..Application to the case of protein aggregation demonstrates that the kinetics of amyloid growth can often be dominated by secondary rather than by primary nucleation events...
  21. ncbi A systematic survey identifies prions and illuminates sequence features of prionogenic proteins
    Simon Alberti
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 137:146-58. 2009
    ..The self-perpetuating states of these proteins present a vast source of heritable phenotypic variation that increases the adaptability of yeast populations to diverse environments...
  22. ncbi Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct
    Mihaela Necula
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    J Biol Chem 282:10311-24. 2007
    Alzheimer disease is characterized by the abnormal aggregation of amyloid beta peptide into extracellular fibrillar deposits known as amyloid plaques...
  23. ncbi Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
    M A Chishti
    Centre for Research in Neurodegenerative Diseases, The Department of Laboratory Medicine, Division of Neurology, University Health Network, University of Toronto, Toronto, Ontario M5S 3H2, Canada
    J Biol Chem 276:21562-70. 2001
    ..transgenic (Tg) models by exploiting the synergistic effects of familial Alzheimer's disease mutations on amyloid beta-peptide (Abeta) biogenesis...
  24. ncbi Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core
    Christian Wasmer
    Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland
    Science 319:1523-6. 2008
    ..We present a structural model based on solid-state nuclear magnetic resonance restraints for amyloid fibrils from the prion-forming domain (residues 218 to 289) of the HET-s protein from the filamentous fungus ..
  25. ncbi Amyloid ion channels: a common structural link for protein-misfolding disease
    Arjan Quist
    Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 102:10427-32. 2005
    ..and Parkinson's diseases, result from protein misfolding, giving a distinct fibrillar feature termed amyloid. Recent studies show that only the globular (not fibrillar) conformation of amyloid proteins is sufficient to ..
  26. ncbi Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
    D R Borchelt
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 19:939-45. 1997
    ..of experimental in vitro and in vivo settings, FAD-linked presenilin variants influence the processing of the amyloid precursor protein (APP), leading to elevated levels of the highly fibrillogenic Abeta1-42 peptides that are ..
  27. ncbi Prion-like transmission of protein aggregates in neurodegenerative diseases
    Patrik Brundin
    Patrik Brundin is at the Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, BMC A10, 221 84 Lund, Sweden
    Nat Rev Mol Cell Biol 11:301-7. 2010
    ..The transfer of naked infectious particles between cells could therefore be a target for new disease-modifying therapies...
  28. ncbi Functional amyloid--from bacteria to humans
    Douglas M Fowler
    Department of Chemistry and The Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Biochem Sci 32:217-24. 2007
    b>Amyloid--a fibrillar, cross beta-sheet quaternary structure--was first discovered in the context of human disease and tissue damage, and was thought to always be detrimental to the host...
  29. ncbi EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
    Dagmar E Ehrnhoefer
    Max Delbrueck Center for Molecular Medicine, AG Neuroproteomics, 13092 Berlin, Germany
    Nat Struct Mol Biol 15:558-66. 2008
    The accumulation of beta-sheet-rich amyloid fibrils or aggregates is a complex, multistep process that is associated with cellular toxicity in a number of human protein misfolding disorders, including Parkinson's and Alzheimer's diseases...
  30. ncbi Amyloid imaging in mild cognitive impairment subtypes
    David A Wolk
    Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 19104, USA
    Ann Neurol 65:557-68. 2009
    We utilized the amyloid imaging ligand Pittsburgh Compound B (PiB) to determine the presence of Alzheimer's disease (AD) pathology in different mild cognitive impairment (MCI) subtypes and to relate increased PiB binding to other markers ..
  31. ncbi Functional amyloid formation within mammalian tissue
    Douglas M Fowler
    Department of Chemistry, The Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, California, USA
    PLoS Biol 4:e6. 2006
    b>Amyloid is a generally insoluble, fibrous cross-beta sheet protein aggregate. The process of amyloidogenesis is associated with a variety of neurodegenerative diseases including Alzheimer, Parkinson, and Huntington disease...
  32. ncbi Fibril fragmentation enhances amyloid cytotoxicity
    Wei Feng Xue
    Astbury Centre for Structural Molecular Biology, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 284:34272-82. 2009
    Fibrils associated with amyloid disease are molecular assemblies of key biological importance, yet how cells respond to the presence of amyloid remains unclear...
  33. ncbi The transcellular spread of cytosolic amyloids, prions, and prionoids
    Adriano Aguzzi
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Neuron 64:783-90. 2009
    ....
  34. ncbi Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    J Biol Chem 284:4230-7. 2009
    b>Amyloid oligomers are believed to play causal roles in several types of amyloid-related neurodegenerative diseases...
  35. ncbi Exploring the sequence determinants of amyloid structure using position-specific scoring matrices
    Sebastian Maurer-Stroh
    VIB Switch Laboratory, Flanders Institute for Biotechnology and Vrije Universiteit Brussel, Brussels, Belgium
    Nat Methods 7:237-42. 2010
    ..results in beta-sheet-like assemblies that adopt either a variety of amorphous morphologies or ordered amyloid-like structures...
  36. ncbi Stacked sets of parallel, in-register beta-strands of beta2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labeling
    Carol L Ladner
    Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 285:17137-47. 2010
    beta(2)-microglobulin (beta(2)m) is a 99-residue protein with an immunoglobulin fold that forms beta-sheet-rich amyloid fibrils in dialysis-related amyloidosis...
  37. ncbi Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfolding
    Zheng Zhou
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    J Biol Chem 284:30148-58. 2009
    ..3) Macromolecular crowding dramatically accelerates amyloid formation by human prion protein...
  38. ncbi Two amyloid States of the prion protein display significantly different folding patterns
    Valeriy G Ostapchenko
    Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, MD 21201, USA
    J Mol Biol 400:908-21. 2010
    It has been well established that a single amino acid sequence can give rise to several conformationally distinct amyloid states...
  39. ncbi Amyloid peptide channels
    B L Kagan
    Department of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine, UCLA, Los Angeles, California 90024 1759, USA
    J Membr Biol 202:1-10. 2004
    ..prion diseases), are characterized by the deposition of amorphous, Congo red-staining deposits known as amyloid. These "misfolded" proteins adopt beta-sheet structures and aggregate spontaneously into similar ..
  40. ncbi Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway
    Tatyana Gurlo
    Larry Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 7073, USA
    Am J Pathol 176:861-9. 2010
    The islet in type 2 diabetes mellitus (T2DM) is characterized by a deficit in beta cells and islet amyloid derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by beta cells...
  41. ncbi Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008
    To characterize the prevalence of amyloid deposition in a clinically unimpaired elderly population, as assessed by Pittsburgh Compound B (PiB) positron emission tomography (PET) imaging, and its relationship to cognitive function, ..
  42. ncbi The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals
    Bradford C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Cereb Cortex 19:497-510. 2009
    ..Furthermore, subtle thinning is present in asymptomatic older controls with brain amyloid binding as detected with amyloid imaging...
  43. ncbi Molecular mechanism of Thioflavin-T binding to amyloid fibrils
    Matthew Biancalana
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1804:1405-12. 2010
    Intense efforts to detect, diagnose, and analyze the kinetic and structural properties of amyloid fibrils have generated a powerful toolkit of amyloid-specific molecular probes...
  44. ncbi Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering
    Anders Sandberg
    Institute of Biomedicine, University of Gothenburg, SE 405 30 Gothenburg, Sweden
    Proc Natl Acad Sci U S A 107:15595-600. 2010
    Soluble oligomeric aggregates of the amyloid-beta peptide (Abeta) have been implicated in the pathogenesis of Alzheimer's disease (AD)...
  45. ncbi Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis
    Leena Haataja
    Larry Hillblom Islet Research Center, UCLA David Geffen School of Medicine, 900 Weyburn Place A, Los Angeles, California 90024 2852, USA
    Endocr Rev 29:303-16. 2008
    ..resistance, defective insulin secretion, loss of beta-cell mass with increased beta-cell apoptosis and islet amyloid. The islet amyloid is derived from islet amyloid polypeptide (IAPP, amylin), a protein coexpressed and cosecreted ..
  46. ncbi Conformational variations in an infectious protein determine prion strain differences
    Motomasa Tanaka
    Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California-San Francisco, San Francisco, California 94143, USA
    Nature 428:323-8. 2004
    ..Infection of yeast with these different amyloid conformations leads to different [PSI+] strains...
  47. ncbi Molecular basis for insulin fibril assembly
    Magdalena I Ivanova
    Howard Hughes Medical Institute, UCLA DOE Institute for Genomics and Proteomics, Los Angeles CA 90095 1570, USA
    Proc Natl Acad Sci U S A 106:18990-5. 2009
    ..into pairs of tightly interdigitated beta-sheets, each pair displaying the dry steric zipper interface typical of amyloid-like fibrils...
  48. ncbi Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition
    Donna M Wilcock
    Alzheimer's Research Laboratory, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci 24:6144-51. 2004
    The role of microglia in the removal of amyloid deposits after systemically administered anti-Abeta antibodies remains unclear...
  49. ncbi Techniques to study amyloid fibril formation in vitro
    Melanie R Nilsson
    Department of Chemistry, McDaniel College, Eaton Hall, 2 College Hill, Westminster, MD 21157, USA
    Methods 34:151-60. 2004
    b>Amyloid fibrils are ordered aggregates of peptides or proteins that are fibrillar in structure and contribute to the complications of many diseases (e.g., type 2 diabetes mellitus, Alzheimer's disease, and primary systemic amyloidosis)...
  50. ncbi Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation
    Liming Hou
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106-7078, USA
    J Am Chem Soc 126:1992-2005. 2004
    ..by the aggregation and fibrillation of the 40-residue A beta(1-40) and 42-residue A beta(1-42) peptides into amyloid plaques...
  51. ncbi In vitro conversion of full-length mammalian prion protein produces amyloid form with physical properties of PrP(Sc)
    Olga V Bocharova
    Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    J Mol Biol 346:645-59. 2005
    ..that the infectious agent of prion diseases, PrP(Sc), is composed of the prion protein (PrP) converted into an amyloid-specific conformation...
  52. ncbi Disruption of functional connectivity in clinically normal older adults harboring amyloid burden
    Trey Hedden
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Neurosci 29:12686-94. 2009
    b>Amyloid deposition is present in 20-50% of nondemented older adults yet the functional consequences remain unclear...
  53. ncbi A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
    Rolf Postina
    Institute of Biochemistry, University of Mainz, Mainz, Germany
    J Clin Invest 113:1456-64. 2004
    Alzheimer disease (AD) is characterized by excessive deposition of amyloid beta-peptides (A beta peptides) in the brain...
  54. ncbi Amyloid beta protein: Abeta40 inhibits Abeta42 oligomerization
    Megan M Murray
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106 950, USA
    J Am Chem Soc 131:6316-7. 2009
    ..Abeta42, however, is significantly more neurotoxic than Abeta40 and forms amyloid fibrils much more rapidly than Abeta40...
  55. ncbi The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compounds
    Sean A Hudson
    School of Chemistry and Physics, The University of Adelaide, Australia
    FEBS J 276:5960-72. 2009
    Thioflavin T (ThT) dye fluorescence is used regularly to quantify the formation and inhibition of amyloid fibrils in the presence of anti-amyloidogenic compounds such as polyphenols...
  56. ncbi Cytosolic accumulation of HPV16 E7 oligomers supports different transformation routes for the prototypic viral oncoprotein: the amyloid-cancer connection
    Karina Dantur
    Instituto Leloir and Instituto de Investigaciones Bioquímicas Buenos Aires, CONICET, Patricias Argentinas 435, C1405BWE Ciudad Autonoma de Buenos Aires, Argentina
    Int J Cancer 125:1902-11. 2009
    ..The protein can form spherical oligomers with amyloid-like properties and chaperone activity...
  57. ncbi Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    EMBO Mol Med 1:371-80. 2009
    ..We previously reported that cerebrospinal fluid (CSF) levels of amyloid-beta(42) (Abeta(42)) serve as an excellent marker for brain amyloid as detected by the amyloid tracer, Pittsburgh ..
  58. ncbi Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy
    Gregory A Dierksen
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ann Neurol 68:545-8. 2010
    Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined...
  59. ncbi Magic angle spinning NMR analysis of beta2-microglobulin amyloid fibrils in two distinct morphologies
    Galia T Debelouchina
    Department of Chemistry and Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 132:10414-23. 2010
    Beta(2)-microglobulin (beta(2)m) is the major structural component of amyloid fibrils deposited in a condition known as dialysis-related amyloidosis...
  60. ncbi Amyloid efflux transporter expression at the blood-brain barrier declines in normal aging
    Gerald D Silverberg
    Department of Neurosurgery, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
    J Neuropathol Exp Neurol 69:1034-43. 2010
    Reduced clearance of amyloid β peptides (Aβ) across the blood-brain barrier contributes to amyloid accumulation in Alzheimer disease...
  61. ncbi Biology of amyloid: structure, function, and regulation
    Jason Greenwald
    ETH Zurich, Physical Chemistry, ETH Honggerberg, 8093 Zurich, Switzerland
    Structure 18:1244-60. 2010
    ..It grows by recruitment of the corresponding amyloid protein, while its repetitiveness can translate what would be a nonspecific activity as monomer into a potent one ..
  62. ncbi Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
    Paul Edison
    MRC Clinical Sciences Centre, Cyclotron Building Hammersmith Hospital, Imperial College London, UK
    Neurobiol Dis 32:412-9. 2008
    11C](R)PK11195-PET is a marker of activated microglia while [11C]PIB-PET detects raised amyloid load...
  63. ncbi Amyloid deposits: protection against toxic protein species?
    Sebastian Treusch
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Cell Cycle 8:1668-74. 2009
    ..In several cases the intracellular and extracellular protein deposits contain a fibrillar protein species called amyloid. However while amyloid deposits are hallmarks of numerous neurodegenerative diseases, their actual role in ..
  64. ncbi Structural characterization of a soluble amyloid beta-peptide oligomer
    Liping Yu
    Pharmaceutical Discovery Division, GPRD, Abbott Laboratories, Abbott Park, Illinois 60064 6098, USA
    Biochemistry 48:1870-7. 2009
    Alzheimer's disease (AD) is a neurodegenerative disorder that is linked to the presence of amyloid beta-peptides that can form insoluble fibrils or soluble oligomeric assemblies...
  65. ncbi Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice
    Anne Eckert
    Neurobiology Laboratory, Psychiatric University Clinic Basel, Wilhelm Klein Strasse 27, 4025, Basel, Switzerland
    J Mol Med (Berl) 86:1255-67. 2008
    ..Finally, we found that aging specifically increased the sensitivity of mitochondria to oligomeric A beta 42 damage indicating that oligomeric and fibrillar A beta 42 are both toxic, but exert different degrees of toxicity...
  66. ncbi Glycosaminoglycans enhance the trifluoroethanol-induced extension of beta 2-microglobulin-related amyloid fibrils at a neutral pH
    Suguru Yamamoto
    Department of Pathology, Fukui Medical University, Fukui, Japan
    J Am Soc Nephrol 15:126-33. 2004
    ..in patients on long-term dialysis, and beta(2)-microglobulin is a major structural component of A beta 2M amyloid fibrils...
  67. ncbi Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition
    Andrei G Vlassenko
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:17763-7. 2010
    b>Amyloid-β (Aβ) plaque deposition can precede the clinical manifestations of dementia of the Alzheimer type (DAT) by many years and can be associated with changes in brain metabolism...
  68. ncbi Glycogen synthase kinase-3beta, or a link between amyloid and tau pathology?
    D Muyllaert
    Experimental Genetics Group, K U Leuven, Leuven, Belgium
    Genes Brain Behav 7:57-66. 2008
    ..has been invoked in disease mechanisms, and the case of Alzheimer's disease (AD) is no exception: both in the amyloid pathology and in the tauopathy are kinases deeply implicated...
  69. ncbi Clearing amyloid through the blood-brain barrier
    Berislav V Zlokovic
    Frank P Smith Laboratories for Neuroscience, Department of Neurological Surgery, University of Rochester Medical Center, New York 14642, USA
    J Neurochem 89:807-11. 2004
    According to the amyloid hypothesis, accumulation of amyloid beta-peptide (A beta) in the brain is the primary pathogenic event in Alzheimer's disease (AD)...
  70. ncbi Mysterious oligomerization of the amyloidogenic proteins
    Vladimir N Uversky
    Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    FEBS J 277:2940-53. 2010
    ..Protein aggregation is a very complex process characterized by a remarkable polymorphism, where soluble amyloid oligomers, amyloid fibrils and amorphous aggregates are found as final products...
  71. ncbi The solvent protection of alzheimer amyloid-beta-(1-42) fibrils as determined by solution NMR spectroscopy
    Anders Olofsson
    Umea Centre for Molecular Pathogenesis, Umea University, SE 901 87 Umea, Sweden
    J Biol Chem 281:477-83. 2006
    Alzheimer disease is a neurodegenerative disorder that is tightly linked to the self-assembly and amyloid formation of the 39-43-residue-long amyloid-beta (Abeta) peptide...
  72. ncbi Candida albicans Als adhesins have conserved amyloid-forming sequences
    Henry N Otoo
    Department of Biology, Brooklyn College, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    Eukaryot Cell 7:776-82. 2008
    ..This aggregation is amyloid-like, with self-propagating secondary-structure changes, amyloid-characteristic dye binding, and induced ..
  73. ncbi Immune reactivity towards insulin, its amyloid and protein S100B in blood sera of Parkinson's disease patients
    K R Wilhelm
    Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
    Eur J Neurol 14:327-34. 2007
    ..We did not detect any pronounced immune reactions towards insulin amyloid fibrils and oligomers in PD patients, indicating that an amyloid-specific conformational epitope is not involved ..
  74. ncbi Structure, function and amyloidogenic propensity of apolipoprotein A-I
    Laura Obici
    Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Laboratorio di Biotecnologie, IRCCS Policlinico San Matteo, Pavia, Italy
    Amyloid 13:191-205. 2006
    ..The wild-type molecule also has an intrinsic tendency to generate amyloid fibrils that localise within the atherosclerotic plaques...
  75. ncbi Evidence for novel beta-sheet structures in Iowa mutant beta-amyloid fibrils
    Robert Tycko
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0520, USA
    Biochemistry 48:6072-84. 2009
    Asp23-to-Asn mutation within the coding sequence of beta-amyloid, called the Iowa mutation, is associated with early onset, familial Alzheimer's disease and cerebral amyloid angiopathy, in which patients develop neuritic plaques and ..
  76. ncbi Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
    R E Tanzi
    Science 235:880-4. 1987
    The amyloid beta protein has been identified as an important component of both cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome...
  77. ncbi Native-unlike long-lived intermediates along the folding pathway of the amyloidogenic protein beta2-microglobulin revealed by real-time two-dimensional NMR
    Alessandra Corazza
    Department of Biomedical Science and Technology, University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy
    J Biol Chem 285:5827-35. 2010
    ..and, in patients undergoing long term dialysis, the full-length and chemically unmodified beta2m converts into amyloid fibrils...
  78. ncbi Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration
    Elpida Tsika
    The Children s Hospital of Philadelphia Research Institute, Philadelphia Pennsylvania 19104, USA
    J Neurosci 30:3409-18. 2010
    ....
  79. ncbi Potential pathogenic role of beta-amyloid(1-42)-aluminum complex in Alzheimer's disease
    Denise Drago
    Department of Biology, University of Padova, Viale G Colombo, 3 35121 Padova, Italy
    Int J Biochem Cell Biol 40:731-46. 2008
    ..the involvement of metal ions as a potential key factor towards conformational modifications and aggregation of amyloid is widely recognized...
  80. ncbi Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model
    Jun Yao
    Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Mol Cell Neurosci 35:377-82. 2007
    Alzheimer's patients have increased levels of both the 42 beta amyloid-beta-peptide (Abeta) and amyloid binding alcohol dehydrogenase (ABAD) which is an intracellular binding site for Abeta...
  81. ncbi Conformational conversion during amyloid formation at atomic resolution
    Timo Eichner
    Astbury Centre for Structural Molecular Biology and Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
    Mol Cell 41:161-72. 2011
    Numerous studies of amyloid assembly have indicated that partially folded protein species are responsible for initiating aggregation...
  82. ncbi EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity
    Jan Bieschke
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13125 Berlin Buch, Germany
    Proc Natl Acad Sci U S A 107:7710-5. 2010
    Protein misfolding and formation of beta-sheet-rich amyloid fibrils or aggregates is related to cellular toxicity and decay in various human disorders including Alzheimer's and Parkinson's disease...
  83. ncbi Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice
    Dick Terwel
    Experimental Genetics Group, Department Human Genetics, Katholieke Universiteit Leuven Campus Gasthuisberg ON1 06 602, B 3000 Leuven, Belgium
    Am J Pathol 172:786-98. 2008
    The hypothesis that amyloid pathology precedes and induces the tau pathology of Alzheimer's disease is experimentally supported here through the identification of GSK-3 isozymes as a major link in the signaling pathway from amyloid to ..
  84. ncbi Formation of amyloids by Abeta-(1-42) on NGF-differentiated PC12 cells: roles of gangliosides and cholesterol
    Masaki Wakabayashi
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606 8501, Japan
    J Mol Biol 371:924-33. 2007
    The conversion of soluble, non-toxic amyloid beta-protein (Abeta) to aggregated, toxic Abeta could be the key step in the development of Alzheimer's disease...
  85. ncbi Premelanosome amyloid-like fibrils are composed of only golgi-processed forms of Pmel17 that have been proteolytically processed in endosomes
    Dawn C Harper
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6100, USA
    J Biol Chem 283:2307-22. 2008
    ..These data have important implications for the site and mechanism of fibril formation...
  86. ncbi The fold of alpha-synuclein fibrils
    Marçal Vilar
    The Salk Institute for Biological Studies, North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:8637-42. 2008
    The aggregation of proteins into amyloid fibrils is associated with several neurodegenerative diseases...
  87. ncbi Amyloid formation by globular proteins under native conditions
    Fabrizio Chiti
    Dipartimento di Scienze Biochimiche, Universita degli Studi di Firenze, Viale Morgagni 50, I 50134 Firenze, Italy
    Nat Chem Biol 5:15-22. 2009
    ..We review recent evidence on this topic and discuss its significance for understanding the onset and potential inhibition of protein aggregation in the context of diseases...
  88. ncbi Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation
    Jill A White
    Department of Medicine, Division of Geriatrics, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201, USA
    Neurobiol Dis 18:459-65. 2005
    Activated glia, as a result of chronic inflammation, are associated with amyloid-beta peptide (Abeta) deposits in the brain of Alzheimer's disease (AD) patients...
  89. ncbi Threats to the mind: aging, amyloid, and hypertension
    Costantino Iadecola
    Division of Neurobiology, Weill Medical College of Cornell University, 411 East 69th Street KB410, New York, NY 10021, USA
    Stroke 40:S40-4. 2009
    ....
  90. ncbi Amyloid disease prevention by transthyretin native state complexation with carborane derivatives lacking cyclooxygenase inhibition
    Richard L Julius
    University of California, Los Angeles, California, USA
    Drug News Perspect 21:258-66. 2008
    Misfolding and subsequent aggregation of any of a number of proteins leads to the accumulation of amyloid fibrils, which have been associated with a variety of diseases...
  91. ncbi A cylinder-shaped double ribbon structure formed by an amyloid hairpin peptide derived from the beta-sheet of murine PrP: an X-ray and molecular dynamics simulation study
    Vincent Croixmarie
    CEA, DAM, 91680 Bruyères le Châtel, France
    J Struct Biol 150:284-99. 2005
    ..The present findings provide also a simple model for further investigating the sequence-stability relationship using a mutational approach with a quasi-independent consideration of the polar and apolar interactions...
  92. ncbi Effects of the sequence and size of non-polar residues on self-assembly of amphiphilic peptides
    Kai Wang
    Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA
    Int J Biol Macromol 36:232-40. 2005
    ..The sequence and steric size of non-polar residues are shown to cause variations in peptide secondary structures and create significant differences in the matrix morphology of self-assembled peptides...
  93. ncbi Amyloid-like fibril formation of co-chaperonin GroES: nucleation and extension prefer different degrees of molecular compactness
    Takashi Higurashi
    Department of Biotechnology, Faculty of Engineering, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama Minami, Tottori 680 8552, Japan
    J Mol Biol 351:1057-69. 2005
    ..Here, we report on the in vitro formation of GroES amyloid-like fibrils and the mechanism of formation...
  94. ncbi Protein misfolding and amyloid formation for the peptide GNNQQNY from yeast prion protein Sup35: simulation by reaction path annealing
    Jan Lipfert
    Department of Physics, Stanford University, Stanford CA 94305, USA
    J Mol Biol 349:648-58. 2005
    We study the early steps of amyloid formation of the seven residue peptide GNNQQNY from yeast prion-like protein Sup35 by simulating the random coil to beta-sheet and alpha-helix to beta-sheet transition both in the absence and presence ..
  95. ncbi Aggregation of partially unfolded Myosin subfragment-1 into spherical oligomers with amyloid-like dye-binding properties
    Hideyuki Komatsu
    Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Iizuka, Fukuoka, 820 8502
    J Biochem 139:989-96. 2006
    ..the aggregate thus formed were: (i) formation of transparent sediment under centrifugation at 183,000 x g; (ii) amyloid-like, dye-binding properties such as Congo red-binding and Thioflavin T fluorescence enhancement; (iii) a ..
  96. ncbi Inhibiting transthyretin conformational changes that lead to amyloid fibril formation
    S A Peterson
    Department of Chemistry and Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road MB 12, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 95:12956-60. 1998
    ..the self-assembly of a conformational intermediate are implicated as the causative agent in several severe human amyloid diseases, including Alzheimer's disease, familial amyloid polyneuropathy, and senile systemic amyloidosis...
  97. ncbi Direct observation of protein folding, aggregation, and a prion-like conformational conversion
    Feng Ding
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 280:40235-40. 2005
    ..At high temperatures, this peptide adopts an amyloid-like structure, which is mainly composed of coiled anti-parallel beta-sheets with the cross-beta-signature of ..
  98. ncbi Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs
    Huan Wang
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 805b Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:7159-64. 2008
    ..are unlikely to perturb large intermolecular protein-protein interfaces, let alone extraordinarily stable amyloid interfaces...
  99. ncbi Intermediate amyloid oligomers of lysozyme: Is their cytotoxicity a particular case or general rule for amyloid?
    M Malisauskas
    Department of Medical Biochemistry and Biophysics, Umea University, Umea 90187, Sweden
    Biochemistry (Mosc) 71:505-12. 2006
    In the current study we investigated the molecular mechanisms of cytotoxicity of amyloid oligomers of horse milk lysozyme. We have shown that lysozyme forms soluble amyloid oligomers and protofibrils during incubation at pH 2.0 and 4...
  100. ncbi The effect of Abeta conformation on the metal affinity and aggregation mechanism studied by circular dichroism spectroscopy
    Y R Chen
    Institute of Medical Science, Tzu Chi University, Hualien, Taiwan
    J Biochem (Tokyo) 139:733-40. 2006
    The conformational change and associated aggregation of beta amyloid (Abeta) with or without metals is the main cause of Alzheimer's disease (AD)...
  101. ncbi Protein aggregation and its consequences for human disease
    Christopher M Dobson
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Protein Pept Lett 13:219-27. 2006
    ..In such diseases, aggregated proteins can often be observed as highly intractable thread-like species known as amyloid fibrils...

Research Grants92

  1. Preclinical Diagnostic Imaging of Amyloid
    Jonathan S Wall; Fiscal Year: 2010
    b>Amyloid is associated with a diverse group of often fatal hereditary and sporadic protein misfolding disorders, characterized by the deposition of fibrils and heparan sulfate proteoglycan in vital organs and tissues...
  2. Implication of HUCBC: a novel therapeutic strategy for Alzheimer's disease
    Jun Tan; Fiscal Year: 2010
    ..this downregulation of neurotoxic innate responses and upregulation of salutary humoral responses, A levels/- amyloid deposits and cerebral amyloid angiopathy (CAA;an inflammatory response to vascular amyloid deposits) are reduced ..
  3. Implication of HUCBC: a novel therapeutic strategy for Alzheimer's disease
    Jun Tan; Fiscal Year: 2009
    ..this downregulation of neurotoxic innate responses and upregulation of salutary humoral responses, A levels/- amyloid deposits and cerebral amyloid angiopathy (CAA; an inflammatory response to vascular amyloid deposits) are reduced ..
  4. Preclinical Diagnostic Imaging of Amyloid
    Jonathan Wall; Fiscal Year: 2009
    b>Amyloid is associated with a diverse group of often fatal hereditary and sporadic protein misfolding disorders, characterized by the deposition of fibrils and heparan sulfate proteoglycan in vital organs and tissues...
  5. Mechanisms of Microglial Activation and Phagocytosis in*
    Gary Landreth; Fiscal Year: 2005
    Alzheimer's disease is characterized by the extensive deposition of fibrillar forms of beta-amyloid (AB) peptides into the extracellular space, and their compaction into senile plaques...
  6. Cholesterol and copper affect learning and memory
    BERNARD SCHREURS; Fiscal Year: 2007
    ..A high cholesterol diet has been shown to result in beta amyloid deposits - one the hallmarks of Alzheimer's disease...
  7. SOLUTION STRUCTURE OF THE AMYLOID BETA (1/42)
    Michael Zagorski; Fiscal Year: 1999
    DESCRIPTION The 42-residue, beta-(1-42) peptide is the predominant protein component of amyloid plaque core deposits in Alzheimer's disease (AD). The beta-(1-42) nucleates amyloid formation...
  8. Protein Amyloidogenesis in the Epididymis: Mechanisms and Biological Significance
    Gail Cornwall; Fiscal Year: 2010
    The long range objective of our studies is to determine the biological significance of amyloid-type protein aggregation and mechanisms for its control in the epididymal lumen using the cystatins as molecular models...
  9. Protein Amyloidogenesis in the Epididymis: Mechanisms and Biological Significance
    Gail Cornwall; Fiscal Year: 2009
    The long range objective of our studies is to determine the biological significance of amyloid-type protein aggregation and mechanisms for its control in the epididymal lumen using the cystatins as molecular models...
  10. Early Detection of Cerebral Amyloid Angiopathy
    Steven M Greenberg; Fiscal Year: 2010
    Deposition of ss-amyloid (Ass) in the cerebral vessels (cerebral amyloid angiopathy or CAA) is a major cause of hemorrhagic stroke, a contributor to vascular cognitive impairment, and a complicating factor in attempts to develop anti-..
  11. Proteoglycans/Glycosaminoglycans in APP Transgenic Mice
    ALAN SNOW; Fiscal Year: 2004
    ..AD is characterized by the accumulation of insoluble fibrillar amyloid deposits containing the beta-amyloid protein (Abeta), either as extracellular amyloid plaques in the brain ..
  12. Roles of reticulon proteins in neurodegenerative diseases
    Riqiang Yan; Fiscal Year: 2010
    ..We demonstrated that increased expression of RTN3 in mice reduced amyloid deposition in cortical brain regions...
  13. Cholesterol and copper affect learning and memory
    BERNARD SCHREURS; Fiscal Year: 2009
    ..A high cholesterol diet has been shown to result in beta amyloid deposits - one the hallmarks of Alzheimer's disease...
  14. Molecular mechanism of senile cardiac amyloidosis
    Lawreen H Connors; Fiscal Year: 2010
    Cardiomyopathy in elderly men can be the result of extracellular deposits of amyloid in the heart, pathology referred to as Senile Systemic (or Cardiac) Amyloidosis (SSA)...
  15. Structural Characterization of Amyloid Fibrils Using Deep UV Raman Spectroscopy
    Igor K Lednev; Fiscal Year: 2010
    b>Amyloid fibrils are associated with numerous debilitating diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, prion disease, familial amyloid polyneuropathy, senile systemic amyloidosis and ..
  16. METABOLISM OF SERUM AMYLOID A (SAA:HDL)
    Barbara Kluve Beckerman; Fiscal Year: 2007
    ..arthritis and familial Mediterranean fever, and is characterized by extracellular fibrillar deposits of amyloid A (AA) protein, a peptide proteolytically derived from the acute phase reactant serum amyloid A (SAA)...
  17. Magnetic Resonance Imaging of Alzheimer's Amyloid Plaque
    JOSEPH PODUSLO; Fiscal Year: 2007
    This project will test the hypothesis that modifications of amyloid-beta protein (A beta) or derivatives of A beta can be used for the molecular imaging of amyloid plaques in Alzheimer's disease (AD)...
  18. TRANSGENIC MICE, INFLAMMATION & THE ALZHEIMER PHENOTYPE
    Marcia N Gordon; Fiscal Year: 2010
    ..Reducing brain amyloid and its consequences is a therapeutic strategy in active development...
  19. Inhibitors of beta-Amyloid Production in Alzheimer's
    Gregory Hook; Fiscal Year: 2007
    ..Abnormal accumulation of extracellular brain beta-amyloid is thought to cause AD and compounds that block beta-amyloid production are predicted to be effective for ..
  20. Investigation of the yeast prion factor [PSI+]
    Susan W Liebman; Fiscal Year: 2010
    The misfolding of different cellular proteins into amyloid-like aggregates is associated with non- infectious neurodegenerative diseases including Alzheimer's, Huntington's and Parkinson's, as well as with the infectious ..
  21. Amyloid-Lowering Small Molecule AB-Binding Agents in AD
    William Klunk; Fiscal Year: 2007
    ..Because of the key role of the amyloid-beta (A?) peptide in the pathophysiology of AD, A? synthesis, deposition and clearance have become important ..
  22. Loss of synapses in physiological and pathological aging
    Pascale Lacor; Fiscal Year: 2003
    ..Alzheimer's disease (AD) is a neurodegenerative disorder that is pathologically characterized by the presence of amyloid deposits composed by filaments of amyloid beta (Abeta) peptide...
  23. Untangling Amyloid Plaques With Proteases
    Jin Moo Lee; Fiscal Year: 2009
    ..A?1-42, the 42 amino-acid peptide fragment of the amyloid precursor protein (APP), has a striking propensity to aggregate into amyloid fibrils within plaques...
  24. Lipoate Derivatives Targeting Alzheimer's Amyloid
    Xudong Huang; Fiscal Year: 2007
    ..Moreover, the exact subserving mechanism(s) of antioxidant/metal chelation effects upon AD amyloid pathology are not clear...
  25. Untangling Amyloid Plaques With Proteases
    Jin Moo Lee; Fiscal Year: 2010
    ..A?1-42, the 42 amino-acid peptide fragment of the amyloid precursor protein (APP), has a striking propensity to aggregate into amyloid fibrils within plaques...
  26. Structure and conformational diversity of amyloid oligomers
    Charles G Glabe; Fiscal Year: 2010
    The goal of this research project is to explore the structural heterogeneity of amyloid aggregates and the relationships of this conformational variation to the toxicity or pathogenic activities of amyloid oligomers...