Genomes and Genes
Summary: A type of extracellularly deposited substance composed of an amyloid protein and additional components including HEPARAN SULFATE PROTEOGLYCAN; LAMININ; COLLAGEN TYPE IV; SERUM AMYLOID P-COMPONENT; and APOLIPOPROTEINS E which together form characteristic amyloid fibrils. The core of amyloid fibrils is formed by the stacking of overlapping beta-pleated sheet domains of the amyloid protein. There are many different amyloid proteins that have been found forming the core of the fibrils in vivo. However, amyloid can be formed from any protein that exposes beta-pleated strand conformations during unfolding or refolding. A common characteristic of amyloid is the ability to bind such dyes as CONGO RED and thioflavine.
Publications295 found, 100 shown here
- Common structure of soluble amyloid oligomers implies common mechanism of pathogenesisRakez Kayed
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
Science 300:486-9. 2003..Soluble oligomers have a unique distribution in human AD brain that is distinct from fibrillar amyloid. These results indicate that different types of soluble amyloid oligomers have a common structure and suggest ..
- Protein misfolding, functional amyloid, and human diseaseFabrizio Chiti
Dipartimento di Scienze Biochimiche, Universita degli Studi di Firenze, I 50134 Firenze, Italy
Annu Rev Biochem 75:333-66. 2006..We review recent advances toward the elucidation of the structures of amyloid fibrils and the mechanisms of their formation at a molecular level...
- Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-BWilliam E Klunk
Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA
Ann Neurol 55:306-19. 2004This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls...
- Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetesSeth L Masters
Immunology Research Centre, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
Nat Immunol 11:897-904. 2010..Here we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid deposits in the pancreas during type 2 diabetes, triggered the ..
- Amyloid plaque core protein in Alzheimer disease and Down syndromeC L Masters
Proc Natl Acad Sci U S A 82:4245-9. 1985We have purified and characterized the cerebral amyloid protein that forms the plaque core in Alzheimer disease and in aged individuals with Down syndrome...
- Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetesAlexandra E Butler
Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Diabetes 52:102-10. 2003....
- Identifying the amylome, proteins capable of forming amyloid-like fibrilsLukasz Goldschmidt
Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095 1570, USA
Proc Natl Acad Sci U S A 107:3487-92. 2010The amylome is the universe of proteins that are capable of forming amyloid-like fibrils. Here we investigate the factors that enable a protein to belong to the amylome...
- Amyloid precursor protein trafficking, processing, and functionGopal Thinakaran
Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 283:29615-9. 2008Intracellular trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations over the past two decades...
- Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's diseaseJia Yao
Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
Proc Natl Acad Sci U S A 106:14670-5. 2009..Mitochondrial amyloid beta (Abeta) level in the 3xTg-AD mice was significantly increased at 9 months and temporally correlated with ..
- In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18)Dean F Wong
Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0807, USA
J Nucl Med 51:913-20. 2010An (18)F-labeled PET amyloid-beta (Abeta) imaging agent could facilitate the clinical evaluation of late-life cognitive impairment by providing an objective measure for Alzheimer disease (AD) pathology...
- The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouseG P Lim
Departments of Medicine and Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
J Neurosci 21:8370-7. 2001..With low-dose but not high-dose curcumin treatment, the astrocytic marker GFAP was reduced, and insoluble beta-amyloid (Abeta), soluble Abeta, and plaque burden were significantly decreased by 43-50%...
- Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memoryRandy L Buckner
Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63105, USA
J Neurosci 25:7709-17. 2005Alzheimer's disease (AD) and antecedent factors associated with AD were explored using amyloid imaging and unbiased measures of longitudinal atrophy in combination with reanalysis of previous metabolic and functional studies...
- Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of AmyloidosisJean D Sipe
Department of Biochemistry Emerita, Boston University School of Medicine, Boston, MA 02118, USA
Amyloid 17:101-4. 2010A system of amyloid fibril nomenclature based on the chemical identity of the amyloid fibril forming protein is recommended...
- Functional amyloids as natural storage of peptide hormones in pituitary secretory granulesSamir K Maji
Laboratory of Physical Chemistry, Eidgenossische Technische Hochschule ETH Zurich, Wolfgang Paulistrasse 10, CH 8093 Zurich, Switzerland
Science 325:328-32. 2009..a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation...
- 3D structure of Alzheimer's amyloid-beta(1-42) fibrilsThorsten Luhrs
The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 102:17342-7. 2005Alzheimer's disease is the most fatal neurodegenerative disorder wherein the process of amyloid-beta (Abeta) amyloidogenesis appears causative...
- Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formationLynette Cegelski
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
Nat Chem Biol 5:913-9. 2009Curli are functional extracellular amyloid fibers produced by uropathogenic Escherichia coli (UPEC) and other Enterobacteriaceae...
- Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functionsHeidi Olzscha
Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Martinsried, Germany
Cell 144:67-78. 2011..Here, we have analyzed the gain-of-function toxicity of artificial β sheet proteins that were designed to form amyloid-like fibrils...
- Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humansAnne M Fagan
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Ann Neurol 59:512-9. 2006b>Amyloid-beta(42) (Abeta(42)) appears central to Alzheimer's disease (AD) pathogenesis and is a major component of amyloid plaques. Mean cerebrospinal fluid (CSF) Abeta(42) is decreased in dementia of the Alzheimer's type...
- A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse modelGiselle P Lim
Department of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
J Neurosci 25:3032-40. 2005..are unknown, we used the APPsw (Tg2576) transgenic mouse model to evaluate the impact of dietary DHA on amyloid precursor protein (APP) processing and amyloid burden...
- An analytical solution to the kinetics of breakable filament assemblyTuomas P J Knowles
Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge CB3 0HE, UK
Science 326:1533-7. 2009..Application to the case of protein aggregation demonstrates that the kinetics of amyloid growth can often be dominated by secondary rather than by primary nucleation events...
- A systematic survey identifies prions and illuminates sequence features of prionogenic proteinsSimon Alberti
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Cell 137:146-58. 2009..The self-perpetuating states of these proteins present a vast source of heritable phenotypic variation that increases the adaptability of yeast populations to diverse environments...
- Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinctMihaela Necula
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
J Biol Chem 282:10311-24. 2007Alzheimer disease is characterized by the abnormal aggregation of amyloid beta peptide into extracellular fibrillar deposits known as amyloid plaques...
- Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695M A Chishti
Centre for Research in Neurodegenerative Diseases, The Department of Laboratory Medicine, Division of Neurology, University Health Network, University of Toronto, Toronto, Ontario M5S 3H2, Canada
J Biol Chem 276:21562-70. 2001..transgenic (Tg) models by exploiting the synergistic effects of familial Alzheimer's disease mutations on amyloid beta-peptide (Abeta) biogenesis...
- Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic coreChristian Wasmer
Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland
Science 319:1523-6. 2008..We present a structural model based on solid-state nuclear magnetic resonance restraints for amyloid fibrils from the prion-forming domain (residues 218 to 289) of the HET-s protein from the filamentous fungus ..
- Amyloid ion channels: a common structural link for protein-misfolding diseaseArjan Quist
Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
Proc Natl Acad Sci U S A 102:10427-32. 2005..and Parkinson's diseases, result from protein misfolding, giving a distinct fibrillar feature termed amyloid. Recent studies show that only the globular (not fibrillar) conformation of amyloid proteins is sufficient to ..
- Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteinsD R Borchelt
Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Neuron 19:939-45. 1997..of experimental in vitro and in vivo settings, FAD-linked presenilin variants influence the processing of the amyloid precursor protein (APP), leading to elevated levels of the highly fibrillogenic Abeta1-42 peptides that are ..
- Prion-like transmission of protein aggregates in neurodegenerative diseasesPatrik Brundin
Patrik Brundin is at the Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, BMC A10, 221 84 Lund, Sweden
Nat Rev Mol Cell Biol 11:301-7. 2010..The transfer of naked infectious particles between cells could therefore be a target for new disease-modifying therapies...
- Functional amyloid--from bacteria to humansDouglas M Fowler
Department of Chemistry and The Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Trends Biochem Sci 32:217-24. 2007b>Amyloid--a fibrillar, cross beta-sheet quaternary structure--was first discovered in the context of human disease and tissue damage, and was thought to always be detrimental to the host...
- EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomersDagmar E Ehrnhoefer
Max Delbrueck Center for Molecular Medicine, AG Neuroproteomics, 13092 Berlin, Germany
Nat Struct Mol Biol 15:558-66. 2008The accumulation of beta-sheet-rich amyloid fibrils or aggregates is a complex, multistep process that is associated with cellular toxicity in a number of human protein misfolding disorders, including Parkinson's and Alzheimer's diseases...
- Amyloid imaging in mild cognitive impairment subtypesDavid A Wolk
Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 19104, USA
Ann Neurol 65:557-68. 2009We utilized the amyloid imaging ligand Pittsburgh Compound B (PiB) to determine the presence of Alzheimer's disease (AD) pathology in different mild cognitive impairment (MCI) subtypes and to relate increased PiB binding to other markers ..
- Functional amyloid formation within mammalian tissueDouglas M Fowler
Department of Chemistry, The Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, California, USA
PLoS Biol 4:e6. 2006b>Amyloid is a generally insoluble, fibrous cross-beta sheet protein aggregate. The process of amyloidogenesis is associated with a variety of neurodegenerative diseases including Alzheimer, Parkinson, and Huntington disease...
- Fibril fragmentation enhances amyloid cytotoxicityWei Feng Xue
Astbury Centre for Structural Molecular Biology, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
J Biol Chem 284:34272-82. 2009Fibrils associated with amyloid disease are molecular assemblies of key biological importance, yet how cells respond to the presence of amyloid remains unclear...
- The transcellular spread of cytosolic amyloids, prions, and prionoidsAdriano Aguzzi
Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
Neuron 64:783-90. 2009....
- Annular protofibrils are a structurally and functionally distinct type of amyloid oligomerRakez Kayed
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
J Biol Chem 284:4230-7. 2009b>Amyloid oligomers are believed to play causal roles in several types of amyloid-related neurodegenerative diseases...
- Exploring the sequence determinants of amyloid structure using position-specific scoring matricesSebastian Maurer-Stroh
VIB Switch Laboratory, Flanders Institute for Biotechnology and Vrije Universiteit Brussel, Brussels, Belgium
Nat Methods 7:237-42. 2010..results in beta-sheet-like assemblies that adopt either a variety of amorphous morphologies or ordered amyloid-like structures...
- Stacked sets of parallel, in-register beta-strands of beta2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labelingCarol L Ladner
Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
J Biol Chem 285:17137-47. 2010beta(2)-microglobulin (beta(2)m) is a 99-residue protein with an immunoglobulin fold that forms beta-sheet-rich amyloid fibrils in dialysis-related amyloidosis...
- Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfoldingZheng Zhou
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
J Biol Chem 284:30148-58. 2009..3) Macromolecular crowding dramatically accelerates amyloid formation by human prion protein...
- Two amyloid States of the prion protein display significantly different folding patternsValeriy G Ostapchenko
Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, MD 21201, USA
J Mol Biol 400:908-21. 2010It has been well established that a single amino acid sequence can give rise to several conformationally distinct amyloid states...
- Amyloid peptide channelsB L Kagan
Department of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine, UCLA, Los Angeles, California 90024 1759, USA
J Membr Biol 202:1-10. 2004..prion diseases), are characterized by the deposition of amorphous, Congo red-staining deposits known as amyloid. These "misfolded" proteins adopt beta-sheet structures and aggregate spontaneously into similar ..
- Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathwayTatyana Gurlo
Larry Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 7073, USA
Am J Pathol 176:861-9. 2010The islet in type 2 diabetes mellitus (T2DM) is characterized by a deficit in beta cells and islet amyloid derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by beta cells...
- Frequent amyloid deposition without significant cognitive impairment among the elderlyHoward Jay Aizenstein
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Arch Neurol 65:1509-17. 2008To characterize the prevalence of amyloid deposition in a clinically unimpaired elderly population, as assessed by Pittsburgh Compound B (PiB) positron emission tomography (PET) imaging, and its relationship to cognitive function, ..
- The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individualsBradford C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Cereb Cortex 19:497-510. 2009..Furthermore, subtle thinning is present in asymptomatic older controls with brain amyloid binding as detected with amyloid imaging...
- Molecular mechanism of Thioflavin-T binding to amyloid fibrilsMatthew Biancalana
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Biochim Biophys Acta 1804:1405-12. 2010Intense efforts to detect, diagnose, and analyze the kinetic and structural properties of amyloid fibrils have generated a powerful toolkit of amyloid-specific molecular probes...
- Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineeringAnders Sandberg
Institute of Biomedicine, University of Gothenburg, SE 405 30 Gothenburg, Sweden
Proc Natl Acad Sci U S A 107:15595-600. 2010Soluble oligomeric aggregates of the amyloid-beta peptide (Abeta) have been implicated in the pathogenesis of Alzheimer's disease (AD)...
- Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesisLeena Haataja
Larry Hillblom Islet Research Center, UCLA David Geffen School of Medicine, 900 Weyburn Place A, Los Angeles, California 90024 2852, USA
Endocr Rev 29:303-16. 2008..resistance, defective insulin secretion, loss of beta-cell mass with increased beta-cell apoptosis and islet amyloid. The islet amyloid is derived from islet amyloid polypeptide (IAPP, amylin), a protein coexpressed and cosecreted ..
- Conformational variations in an infectious protein determine prion strain differencesMotomasa Tanaka
Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California-San Francisco, San Francisco, California 94143, USA
Nature 428:323-8. 2004..Infection of yeast with these different amyloid conformations leads to different [PSI+] strains...
- Molecular basis for insulin fibril assemblyMagdalena I Ivanova
Howard Hughes Medical Institute, UCLA DOE Institute for Genomics and Proteomics, Los Angeles CA 90095 1570, USA
Proc Natl Acad Sci U S A 106:18990-5. 2009..into pairs of tightly interdigitated beta-sheets, each pair displaying the dry steric zipper interface typical of amyloid-like fibrils...
- Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid depositionDonna M Wilcock
Alzheimer's Research Laboratory, University of South Florida, Tampa, Florida 33612, USA
J Neurosci 24:6144-51. 2004The role of microglia in the removal of amyloid deposits after systemically administered anti-Abeta antibodies remains unclear...
- Techniques to study amyloid fibril formation in vitroMelanie R Nilsson
Department of Chemistry, McDaniel College, Eaton Hall, 2 College Hill, Westminster, MD 21157, USA
Methods 34:151-60. 2004b>Amyloid fibrils are ordered aggregates of peptides or proteins that are fibrillar in structure and contribute to the complications of many diseases (e.g., type 2 diabetes mellitus, Alzheimer's disease, and primary systemic amyloidosis)...
- Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formationLiming Hou
Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106-7078, USA
J Am Chem Soc 126:1992-2005. 2004..by the aggregation and fibrillation of the 40-residue A beta(1-40) and 42-residue A beta(1-42) peptides into amyloid plaques...
- In vitro conversion of full-length mammalian prion protein produces amyloid form with physical properties of PrP(Sc)Olga V Bocharova
Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
J Mol Biol 346:645-59. 2005..that the infectious agent of prion diseases, PrP(Sc), is composed of the prion protein (PrP) converted into an amyloid-specific conformation...
- Disruption of functional connectivity in clinically normal older adults harboring amyloid burdenTrey Hedden
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
J Neurosci 29:12686-94. 2009b>Amyloid deposition is present in 20-50% of nondemented older adults yet the functional consequences remain unclear...
- A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse modelRolf Postina
Institute of Biochemistry, University of Mainz, Mainz, Germany
J Clin Invest 113:1456-64. 2004Alzheimer disease (AD) is characterized by excessive deposition of amyloid beta-peptides (A beta peptides) in the brain...
- Amyloid beta protein: Abeta40 inhibits Abeta42 oligomerizationMegan M Murray
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106 950, USA
J Am Chem Soc 131:6316-7. 2009..Abeta42, however, is significantly more neurotoxic than Abeta40 and forms amyloid fibrils much more rapidly than Abeta40...
- The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compoundsSean A Hudson
School of Chemistry and Physics, The University of Adelaide, Australia
FEBS J 276:5960-72. 2009Thioflavin T (ThT) dye fluorescence is used regularly to quantify the formation and inhibition of amyloid fibrils in the presence of anti-amyloidogenic compounds such as polyphenols...
- Cytosolic accumulation of HPV16 E7 oligomers supports different transformation routes for the prototypic viral oncoprotein: the amyloid-cancer connectionKarina Dantur
Instituto Leloir and Instituto de Investigaciones Bioquímicas Buenos Aires, CONICET, Patricias Argentinas 435, C1405BWE Ciudad Autonoma de Buenos Aires, Argentina
Int J Cancer 125:1902-11. 2009..The protein can form spherical oligomers with amyloid-like properties and chaperone activity...
- Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's diseaseAnne M Fagan
Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
EMBO Mol Med 1:371-80. 2009..We previously reported that cerebrospinal fluid (CSF) levels of amyloid-beta(42) (Abeta(42)) serve as an excellent marker for brain amyloid as detected by the amyloid tracer, Pittsburgh ..
- Spatial relation between microbleeds and amyloid deposits in amyloid angiopathyGregory A Dierksen
Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Ann Neurol 68:545-8. 2010Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined...
- Magic angle spinning NMR analysis of beta2-microglobulin amyloid fibrils in two distinct morphologiesGalia T Debelouchina
Department of Chemistry and Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Am Chem Soc 132:10414-23. 2010Beta(2)-microglobulin (beta(2)m) is the major structural component of amyloid fibrils deposited in a condition known as dialysis-related amyloidosis...
- Amyloid efflux transporter expression at the blood-brain barrier declines in normal agingGerald D Silverberg
Department of Neurosurgery, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
J Neuropathol Exp Neurol 69:1034-43. 2010Reduced clearance of amyloid β peptides (Aβ) across the blood-brain barrier contributes to amyloid accumulation in Alzheimer disease...
- Biology of amyloid: structure, function, and regulationJason Greenwald
ETH Zurich, Physical Chemistry, ETH Honggerberg, 8093 Zurich, Switzerland
Structure 18:1244-60. 2010..It grows by recruitment of the corresponding amyloid protein, while its repetitiveness can translate what would be a nonspecific activity as monomer into a potent one ..
- Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET studyPaul Edison
MRC Clinical Sciences Centre, Cyclotron Building Hammersmith Hospital, Imperial College London, UK
Neurobiol Dis 32:412-9. 200811C](R)PK11195-PET is a marker of activated microglia while [11C]PIB-PET detects raised amyloid load...
- Amyloid deposits: protection against toxic protein species?Sebastian Treusch
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Cell Cycle 8:1668-74. 2009..In several cases the intracellular and extracellular protein deposits contain a fibrillar protein species called amyloid. However while amyloid deposits are hallmarks of numerous neurodegenerative diseases, their actual role in ..
- Structural characterization of a soluble amyloid beta-peptide oligomerLiping Yu
Pharmaceutical Discovery Division, GPRD, Abbott Laboratories, Abbott Park, Illinois 60064 6098, USA
Biochemistry 48:1870-7. 2009Alzheimer's disease (AD) is a neurodegenerative disorder that is linked to the presence of amyloid beta-peptides that can form insoluble fibrils or soluble oligomeric assemblies...
- Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic miceAnne Eckert
Neurobiology Laboratory, Psychiatric University Clinic Basel, Wilhelm Klein Strasse 27, 4025, Basel, Switzerland
J Mol Med (Berl) 86:1255-67. 2008..Finally, we found that aging specifically increased the sensitivity of mitochondria to oligomeric A beta 42 damage indicating that oligomeric and fibrillar A beta 42 are both toxic, but exert different degrees of toxicity...
- Glycosaminoglycans enhance the trifluoroethanol-induced extension of beta 2-microglobulin-related amyloid fibrils at a neutral pHSuguru Yamamoto
Department of Pathology, Fukui Medical University, Fukui, Japan
J Am Soc Nephrol 15:126-33. 2004..in patients on long-term dialysis, and beta(2)-microglobulin is a major structural component of A beta 2M amyloid fibrils...
- Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) depositionAndrei G Vlassenko
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 107:17763-7. 2010b>Amyloid-β (Aβ) plaque deposition can precede the clinical manifestations of dementia of the Alzheimer type (DAT) by many years and can be associated with changes in brain metabolism...
- Glycogen synthase kinase-3beta, or a link between amyloid and tau pathology?D Muyllaert
Experimental Genetics Group, K U Leuven, Leuven, Belgium
Genes Brain Behav 7:57-66. 2008..has been invoked in disease mechanisms, and the case of Alzheimer's disease (AD) is no exception: both in the amyloid pathology and in the tauopathy are kinases deeply implicated...
- Clearing amyloid through the blood-brain barrierBerislav V Zlokovic
Frank P Smith Laboratories for Neuroscience, Department of Neurological Surgery, University of Rochester Medical Center, New York 14642, USA
J Neurochem 89:807-11. 2004According to the amyloid hypothesis, accumulation of amyloid beta-peptide (A beta) in the brain is the primary pathogenic event in Alzheimer's disease (AD)...
- Mysterious oligomerization of the amyloidogenic proteinsVladimir N Uversky
Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
FEBS J 277:2940-53. 2010..Protein aggregation is a very complex process characterized by a remarkable polymorphism, where soluble amyloid oligomers, amyloid fibrils and amorphous aggregates are found as final products...
- The solvent protection of alzheimer amyloid-beta-(1-42) fibrils as determined by solution NMR spectroscopyAnders Olofsson
Umea Centre for Molecular Pathogenesis, Umea University, SE 901 87 Umea, Sweden
J Biol Chem 281:477-83. 2006Alzheimer disease is a neurodegenerative disorder that is tightly linked to the self-assembly and amyloid formation of the 39-43-residue-long amyloid-beta (Abeta) peptide...
- Candida albicans Als adhesins have conserved amyloid-forming sequencesHenry N Otoo
Department of Biology, Brooklyn College, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
Eukaryot Cell 7:776-82. 2008..This aggregation is amyloid-like, with self-propagating secondary-structure changes, amyloid-characteristic dye binding, and induced ..
- Immune reactivity towards insulin, its amyloid and protein S100B in blood sera of Parkinson's disease patientsK R Wilhelm
Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
Eur J Neurol 14:327-34. 2007..We did not detect any pronounced immune reactions towards insulin amyloid fibrils and oligomers in PD patients, indicating that an amyloid-specific conformational epitope is not involved ..
- Structure, function and amyloidogenic propensity of apolipoprotein A-ILaura Obici
Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Laboratorio di Biotecnologie, IRCCS Policlinico San Matteo, Pavia, Italy
Amyloid 13:191-205. 2006..The wild-type molecule also has an intrinsic tendency to generate amyloid fibrils that localise within the atherosclerotic plaques...
- Evidence for novel beta-sheet structures in Iowa mutant beta-amyloid fibrilsRobert Tycko
Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0520, USA
Biochemistry 48:6072-84. 2009Asp23-to-Asn mutation within the coding sequence of beta-amyloid, called the Iowa mutation, is associated with early onset, familial Alzheimer's disease and cerebral amyloid angiopathy, in which patients develop neuritic plaques and ..
- Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locusR E Tanzi
Science 235:880-4. 1987The amyloid beta protein has been identified as an important component of both cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome...
- Native-unlike long-lived intermediates along the folding pathway of the amyloidogenic protein beta2-microglobulin revealed by real-time two-dimensional NMRAlessandra Corazza
Department of Biomedical Science and Technology, University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy
J Biol Chem 285:5827-35. 2010..and, in patients undergoing long term dialysis, the full-length and chemically unmodified beta2m converts into amyloid fibrils...
- Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegenerationElpida Tsika
The Children s Hospital of Philadelphia Research Institute, Philadelphia Pennsylvania 19104, USA
J Neurosci 30:3409-18. 2010....
- Potential pathogenic role of beta-amyloid(1-42)-aluminum complex in Alzheimer's diseaseDenise Drago
Department of Biology, University of Padova, Viale G Colombo, 3 35121 Padova, Italy
Int J Biochem Cell Biol 40:731-46. 2008..the involvement of metal ions as a potential key factor towards conformational modifications and aggregation of amyloid is widely recognized...
- Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse modelJun Yao
Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Mol Cell Neurosci 35:377-82. 2007Alzheimer's patients have increased levels of both the 42 beta amyloid-beta-peptide (Abeta) and amyloid binding alcohol dehydrogenase (ABAD) which is an intracellular binding site for Abeta...
- Conformational conversion during amyloid formation at atomic resolutionTimo Eichner
Astbury Centre for Structural Molecular Biology and Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
Mol Cell 41:161-72. 2011Numerous studies of amyloid assembly have indicated that partially folded protein species are responsible for initiating aggregation...
- EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicityJan Bieschke
Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13125 Berlin Buch, Germany
Proc Natl Acad Sci U S A 107:7710-5. 2010Protein misfolding and formation of beta-sheet-rich amyloid fibrils or aggregates is related to cellular toxicity and decay in various human disorders including Alzheimer's and Parkinson's disease...
- Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic miceDick Terwel
Experimental Genetics Group, Department Human Genetics, Katholieke Universiteit Leuven Campus Gasthuisberg ON1 06 602, B 3000 Leuven, Belgium
Am J Pathol 172:786-98. 2008The hypothesis that amyloid pathology precedes and induces the tau pathology of Alzheimer's disease is experimentally supported here through the identification of GSK-3 isozymes as a major link in the signaling pathway from amyloid to ..
- Formation of amyloids by Abeta-(1-42) on NGF-differentiated PC12 cells: roles of gangliosides and cholesterolMasaki Wakabayashi
Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606 8501, Japan
J Mol Biol 371:924-33. 2007The conversion of soluble, non-toxic amyloid beta-protein (Abeta) to aggregated, toxic Abeta could be the key step in the development of Alzheimer's disease...
- Premelanosome amyloid-like fibrils are composed of only golgi-processed forms of Pmel17 that have been proteolytically processed in endosomesDawn C Harper
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6100, USA
J Biol Chem 283:2307-22. 2008..These data have important implications for the site and mechanism of fibril formation...
- The fold of alpha-synuclein fibrilsMarçal Vilar
The Salk Institute for Biological Studies, North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 105:8637-42. 2008The aggregation of proteins into amyloid fibrils is associated with several neurodegenerative diseases...
- Amyloid formation by globular proteins under native conditionsFabrizio Chiti
Dipartimento di Scienze Biochimiche, Universita degli Studi di Firenze, Viale Morgagni 50, I 50134 Firenze, Italy
Nat Chem Biol 5:15-22. 2009..We review recent evidence on this topic and discuss its significance for understanding the onset and potential inhibition of protein aggregation in the context of diseases...
- Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammationJill A White
Department of Medicine, Division of Geriatrics, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201, USA
Neurobiol Dis 18:459-65. 2005Activated glia, as a result of chronic inflammation, are associated with amyloid-beta peptide (Abeta) deposits in the brain of Alzheimer's disease (AD) patients...
- Threats to the mind: aging, amyloid, and hypertensionCostantino Iadecola
Division of Neurobiology, Weill Medical College of Cornell University, 411 East 69th Street KB410, New York, NY 10021, USA
Stroke 40:S40-4. 2009....
- Amyloid disease prevention by transthyretin native state complexation with carborane derivatives lacking cyclooxygenase inhibitionRichard L Julius
University of California, Los Angeles, California, USA
Drug News Perspect 21:258-66. 2008Misfolding and subsequent aggregation of any of a number of proteins leads to the accumulation of amyloid fibrils, which have been associated with a variety of diseases...
- A cylinder-shaped double ribbon structure formed by an amyloid hairpin peptide derived from the beta-sheet of murine PrP: an X-ray and molecular dynamics simulation studyVincent Croixmarie
CEA, DAM, 91680 Bruyères le Châtel, France
J Struct Biol 150:284-99. 2005..The present findings provide also a simple model for further investigating the sequence-stability relationship using a mutational approach with a quasi-independent consideration of the polar and apolar interactions...
- Effects of the sequence and size of non-polar residues on self-assembly of amphiphilic peptidesKai Wang
Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA
Int J Biol Macromol 36:232-40. 2005..The sequence and steric size of non-polar residues are shown to cause variations in peptide secondary structures and create significant differences in the matrix morphology of self-assembled peptides...
- Amyloid-like fibril formation of co-chaperonin GroES: nucleation and extension prefer different degrees of molecular compactnessTakashi Higurashi
Department of Biotechnology, Faculty of Engineering, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama Minami, Tottori 680 8552, Japan
J Mol Biol 351:1057-69. 2005..Here, we report on the in vitro formation of GroES amyloid-like fibrils and the mechanism of formation...
- Protein misfolding and amyloid formation for the peptide GNNQQNY from yeast prion protein Sup35: simulation by reaction path annealingJan Lipfert
Department of Physics, Stanford University, Stanford CA 94305, USA
J Mol Biol 349:648-58. 2005We study the early steps of amyloid formation of the seven residue peptide GNNQQNY from yeast prion-like protein Sup35 by simulating the random coil to beta-sheet and alpha-helix to beta-sheet transition both in the absence and presence ..
- Aggregation of partially unfolded Myosin subfragment-1 into spherical oligomers with amyloid-like dye-binding propertiesHideyuki Komatsu
Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Iizuka, Fukuoka, 820 8502
J Biochem 139:989-96. 2006..the aggregate thus formed were: (i) formation of transparent sediment under centrifugation at 183,000 x g; (ii) amyloid-like, dye-binding properties such as Congo red-binding and Thioflavin T fluorescence enhancement; (iii) a ..
- Inhibiting transthyretin conformational changes that lead to amyloid fibril formationS A Peterson
Department of Chemistry and Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road MB 12, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 95:12956-60. 1998..the self-assembly of a conformational intermediate are implicated as the causative agent in several severe human amyloid diseases, including Alzheimer's disease, familial amyloid polyneuropathy, and senile systemic amyloidosis...
- Direct observation of protein folding, aggregation, and a prion-like conformational conversionFeng Ding
Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
J Biol Chem 280:40235-40. 2005..At high temperatures, this peptide adopts an amyloid-like structure, which is mainly composed of coiled anti-parallel beta-sheets with the cross-beta-signature of ..
- Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogsHuan Wang
Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 805b Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 105:7159-64. 2008..are unlikely to perturb large intermolecular protein-protein interfaces, let alone extraordinarily stable amyloid interfaces...
- Intermediate amyloid oligomers of lysozyme: Is their cytotoxicity a particular case or general rule for amyloid?M Malisauskas
Department of Medical Biochemistry and Biophysics, Umea University, Umea 90187, Sweden
Biochemistry (Mosc) 71:505-12. 2006In the current study we investigated the molecular mechanisms of cytotoxicity of amyloid oligomers of horse milk lysozyme. We have shown that lysozyme forms soluble amyloid oligomers and protofibrils during incubation at pH 2.0 and 4...
- The effect of Abeta conformation on the metal affinity and aggregation mechanism studied by circular dichroism spectroscopyY R Chen
Institute of Medical Science, Tzu Chi University, Hualien, Taiwan
J Biochem (Tokyo) 139:733-40. 2006The conformational change and associated aggregation of beta amyloid (Abeta) with or without metals is the main cause of Alzheimer's disease (AD)...
- Protein aggregation and its consequences for human diseaseChristopher M Dobson
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
Protein Pept Lett 13:219-27. 2006..In such diseases, aggregated proteins can often be observed as highly intractable thread-like species known as amyloid fibrils...
- Preclinical Diagnostic Imaging of AmyloidJonathan S Wall; Fiscal Year: 2010b>Amyloid is associated with a diverse group of often fatal hereditary and sporadic protein misfolding disorders, characterized by the deposition of fibrils and heparan sulfate proteoglycan in vital organs and tissues...
- Implication of HUCBC: a novel therapeutic strategy for Alzheimer's diseaseJun Tan; Fiscal Year: 2010..this downregulation of neurotoxic innate responses and upregulation of salutary humoral responses, A levels/- amyloid deposits and cerebral amyloid angiopathy (CAA;an inflammatory response to vascular amyloid deposits) are reduced ..
- Implication of HUCBC: a novel therapeutic strategy for Alzheimer's diseaseJun Tan; Fiscal Year: 2009..this downregulation of neurotoxic innate responses and upregulation of salutary humoral responses, A levels/- amyloid deposits and cerebral amyloid angiopathy (CAA; an inflammatory response to vascular amyloid deposits) are reduced ..
- Preclinical Diagnostic Imaging of AmyloidJonathan Wall; Fiscal Year: 2009b>Amyloid is associated with a diverse group of often fatal hereditary and sporadic protein misfolding disorders, characterized by the deposition of fibrils and heparan sulfate proteoglycan in vital organs and tissues...
- Mechanisms of Microglial Activation and Phagocytosis in*Gary Landreth; Fiscal Year: 2005Alzheimer's disease is characterized by the extensive deposition of fibrillar forms of beta-amyloid (AB) peptides into the extracellular space, and their compaction into senile plaques...
- Cholesterol and copper affect learning and memoryBERNARD SCHREURS; Fiscal Year: 2007..A high cholesterol diet has been shown to result in beta amyloid deposits - one the hallmarks of Alzheimer's disease...
- SOLUTION STRUCTURE OF THE AMYLOID BETA (1/42)Michael Zagorski; Fiscal Year: 1999DESCRIPTION The 42-residue, beta-(1-42) peptide is the predominant protein component of amyloid plaque core deposits in Alzheimer's disease (AD). The beta-(1-42) nucleates amyloid formation...
- Protein Amyloidogenesis in the Epididymis: Mechanisms and Biological SignificanceGail Cornwall; Fiscal Year: 2010The long range objective of our studies is to determine the biological significance of amyloid-type protein aggregation and mechanisms for its control in the epididymal lumen using the cystatins as molecular models...
- Protein Amyloidogenesis in the Epididymis: Mechanisms and Biological SignificanceGail Cornwall; Fiscal Year: 2009The long range objective of our studies is to determine the biological significance of amyloid-type protein aggregation and mechanisms for its control in the epididymal lumen using the cystatins as molecular models...
- Early Detection of Cerebral Amyloid AngiopathySteven M Greenberg; Fiscal Year: 2010Deposition of ss-amyloid (Ass) in the cerebral vessels (cerebral amyloid angiopathy or CAA) is a major cause of hemorrhagic stroke, a contributor to vascular cognitive impairment, and a complicating factor in attempts to develop anti-..
- Proteoglycans/Glycosaminoglycans in APP Transgenic MiceALAN SNOW; Fiscal Year: 2004..AD is characterized by the accumulation of insoluble fibrillar amyloid deposits containing the beta-amyloid protein (Abeta), either as extracellular amyloid plaques in the brain ..
- Roles of reticulon proteins in neurodegenerative diseasesRiqiang Yan; Fiscal Year: 2010..We demonstrated that increased expression of RTN3 in mice reduced amyloid deposition in cortical brain regions...
- Cholesterol and copper affect learning and memoryBERNARD SCHREURS; Fiscal Year: 2009..A high cholesterol diet has been shown to result in beta amyloid deposits - one the hallmarks of Alzheimer's disease...
- Molecular mechanism of senile cardiac amyloidosisLawreen H Connors; Fiscal Year: 2010Cardiomyopathy in elderly men can be the result of extracellular deposits of amyloid in the heart, pathology referred to as Senile Systemic (or Cardiac) Amyloidosis (SSA)...
- Structural Characterization of Amyloid Fibrils Using Deep UV Raman SpectroscopyIgor K Lednev; Fiscal Year: 2010b>Amyloid fibrils are associated with numerous debilitating diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, prion disease, familial amyloid polyneuropathy, senile systemic amyloidosis and ..
- METABOLISM OF SERUM AMYLOID A (SAA:HDL)Barbara Kluve Beckerman; Fiscal Year: 2007..arthritis and familial Mediterranean fever, and is characterized by extracellular fibrillar deposits of amyloid A (AA) protein, a peptide proteolytically derived from the acute phase reactant serum amyloid A (SAA)...
- Magnetic Resonance Imaging of Alzheimer's Amyloid PlaqueJOSEPH PODUSLO; Fiscal Year: 2007This project will test the hypothesis that modifications of amyloid-beta protein (A beta) or derivatives of A beta can be used for the molecular imaging of amyloid plaques in Alzheimer's disease (AD)...
- TRANSGENIC MICE, INFLAMMATION & THE ALZHEIMER PHENOTYPEMarcia N Gordon; Fiscal Year: 2010..Reducing brain amyloid and its consequences is a therapeutic strategy in active development...
- Inhibitors of beta-Amyloid Production in Alzheimer'sGregory Hook; Fiscal Year: 2007..Abnormal accumulation of extracellular brain beta-amyloid is thought to cause AD and compounds that block beta-amyloid production are predicted to be effective for ..
- Investigation of the yeast prion factor [PSI+]Susan W Liebman; Fiscal Year: 2010The misfolding of different cellular proteins into amyloid-like aggregates is associated with non- infectious neurodegenerative diseases including Alzheimer's, Huntington's and Parkinson's, as well as with the infectious ..
- Amyloid-Lowering Small Molecule AB-Binding Agents in ADWilliam Klunk; Fiscal Year: 2007..Because of the key role of the amyloid-beta (A?) peptide in the pathophysiology of AD, A? synthesis, deposition and clearance have become important ..
- Loss of synapses in physiological and pathological agingPascale Lacor; Fiscal Year: 2003..Alzheimer's disease (AD) is a neurodegenerative disorder that is pathologically characterized by the presence of amyloid deposits composed by filaments of amyloid beta (Abeta) peptide...
- Untangling Amyloid Plaques With ProteasesJin Moo Lee; Fiscal Year: 2009..A?1-42, the 42 amino-acid peptide fragment of the amyloid precursor protein (APP), has a striking propensity to aggregate into amyloid fibrils within plaques...
- Lipoate Derivatives Targeting Alzheimer's AmyloidXudong Huang; Fiscal Year: 2007..Moreover, the exact subserving mechanism(s) of antioxidant/metal chelation effects upon AD amyloid pathology are not clear...
- Untangling Amyloid Plaques With ProteasesJin Moo Lee; Fiscal Year: 2010..A?1-42, the 42 amino-acid peptide fragment of the amyloid precursor protein (APP), has a striking propensity to aggregate into amyloid fibrils within plaques...
- Structure and conformational diversity of amyloid oligomersCharles G Glabe; Fiscal Year: 2010The goal of this research project is to explore the structural heterogeneity of amyloid aggregates and the relationships of this conformational variation to the toxicity or pathogenic activities of amyloid oligomers...