desmosterol

Summary

Summary: An intermediate in the synthesis of cholesterol.

Top Publications

  1. ncbi Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line
    Sara Rodríguez-Acebes
    Hospital Ramon y Cajal, Madrid, Spain
    Biochem J 420:305-15. 2009
  2. ncbi First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol
    Emily J Westover
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Steroids 68:159-66. 2003
  3. ncbi Biochemical markers for puberty in the monkey testis: desmosterol and docosahexaenoic acid
    W E Connor
    Department of Medicine, Oregon Health Sciences University, Portland 97201, USA
    J Clin Endocrinol Metab 82:1911-6. 1997
  4. ncbi Uneven distribution of desmosterol and docosahexaenoic acid in the heads and tails of monkey sperm
    W E Connor
    Department of Medicine, Oregon Health Sciences University, Portland 97201, USA
    J Lipid Res 39:1404-11. 1998
  5. ncbi Differential effects of cholesterol and desmosterol on the ligand binding function of the hippocampal serotonin(1A) receptor: implications in desmosterolosis
    Pushpendra Singh
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad 500 007, India
    Biochim Biophys Acta 1788:2169-73. 2009
  6. ncbi Desmosterol may replace cholesterol in lipid membranes
    Daniel Huster
    Junior Research Group Solid State NMR Studies of Membrane Associated Proteins, Biotechnological Biomedical Center, University of Leipzig, Germany
    Biophys J 88:1838-44. 2005
  7. ncbi Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts
    Saara Vainio
    Institute of Biomedicine Anatomy, University of Helsinki, Helsinki FI 00014, Finland
    J Biol Chem 281:348-55. 2006
  8. ncbi ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain
    Nan Wang
    Department of Medicine, Columbia University, PS 8 401, 630 W 168th St, New York, NY 10032, USA
    FASEB J 22:1073-82. 2008
  9. ncbi Unique lipids of primate spermatozoa: desmosterol and docosahexaenoic acid
    D S Lin
    Division of Endocrinology, Metabolism, and Clinical Nutrition, Oregon Health Sciences University, Portland 97201 3098
    J Lipid Res 34:491-9. 1993
  10. ncbi Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay
    Hans C Andersson
    Hayward Genetics Center and Department of Pediatrics, Tulane University Medical School, New Orleans, Louisiana 70112, USA
    Am J Med Genet 113:315-9. 2002

Research Grants

  1. REGULATION OF SPERM EXOCYTOSIS
    Nicholas Cross; Fiscal Year: 2002
  2. APOLIPOPROTEIN ISOFORMS AND RETINAL DEGENERATION
    STEVEN FLIESLER; Fiscal Year: 2007
  3. Significance of CYP46A1 and other P450s in retinal function
    Irina Pikuleva; Fiscal Year: 2007
  4. Cholesterol-metabolizing P450s and Alzheimer's disease
    Irina Pikuleva; Fiscal Year: 2007
  5. Enzyme Targets-Sterol Synthesis-Opportunistic Pathogens
    WILLIAM NES; Fiscal Year: 2004

Scientific Experts

Detail Information

Publications133 found, 100 shown here

  1. ncbi Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line
    Sara Rodríguez-Acebes
    Hospital Ramon y Cajal, Madrid, Spain
    Biochem J 420:305-15. 2009
    ..This pathway is controlled by cholesterol and cholesterol-derived oxysterols. J774 cells cannot convert desmosterol into cholesterol, a defect resulting from the absence of mRNA for sterol-Delta24-reductase...
  2. ncbi First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol
    Emily J Westover
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Steroids 68:159-66. 2003
    We report the first synthesis of the unnatural enantiomer of desmosterol (ent-desmosterol). The sterol nucleus was constructed enantiospecifically, followed by stepwise addition of the side chain...
  3. ncbi Biochemical markers for puberty in the monkey testis: desmosterol and docosahexaenoic acid
    W E Connor
    Department of Medicine, Oregon Health Sciences University, Portland 97201, USA
    J Clin Endocrinol Metab 82:1911-6. 1997
    We previously reported that the sperm of rhesus monkeys and humans uniquely contain large amounts of desmosterol not found in other tissues and have a high concentration of the highly polyunsaturated n-3 fatty acid, docosahexaenoic acid (..
  4. ncbi Uneven distribution of desmosterol and docosahexaenoic acid in the heads and tails of monkey sperm
    W E Connor
    Department of Medicine, Oregon Health Sciences University, Portland 97201, USA
    J Lipid Res 39:1404-11. 1998
    Previously we demonstrated high concentrations of desmosterol and docosahexaenoic acid (DHA, 22:6 n-3) in monkey testes and sperm. Desmosterol, a cholesterol precursor, is not present elsewhere in the body...
  5. ncbi Differential effects of cholesterol and desmosterol on the ligand binding function of the hippocampal serotonin(1A) receptor: implications in desmosterolosis
    Pushpendra Singh
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad 500 007, India
    Biochim Biophys Acta 1788:2169-73. 2009
    ..of cholesterol, we depleted cholesterol from native hippocampal membranes followed by replenishment with desmosterol. Desmosterol is an immediate biosynthetic precursor of cholesterol in the Bloch pathway differing only in a ..
  6. ncbi Desmosterol may replace cholesterol in lipid membranes
    Daniel Huster
    Junior Research Group Solid State NMR Studies of Membrane Associated Proteins, Biotechnological Biomedical Center, University of Leipzig, Germany
    Biophys J 88:1838-44. 2005
    ..For these animals, synthesis of cholesterol was interrupted at the level of its immediate precursor, desmosterol. Since cholesterol is a major and essential constituent of mammalian cellular membranes, we asked whether ..
  7. ncbi Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts
    Saara Vainio
    Institute of Biomedicine Anatomy, University of Helsinki, Helsinki FI 00014, Finland
    J Biol Chem 281:348-55. 2006
    b>Desmosterol is an immediate precursor of cholesterol in the Bloch pathway of sterol synthesis and an abundant membrane lipid in specific cell types...
  8. ncbi ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain
    Nan Wang
    Department of Medicine, Columbia University, PS 8 401, 630 W 168th St, New York, NY 10032, USA
    FASEB J 22:1073-82. 2008
    ..mice, levels of several sterol intermediates in the cholesterol biosynthetic pathway, namely desmosterol, lathosterol, and lanosterol, as well as 27-OH cholesterol, were increased 2- to 3-fold...
  9. ncbi Unique lipids of primate spermatozoa: desmosterol and docosahexaenoic acid
    D S Lin
    Division of Endocrinology, Metabolism, and Clinical Nutrition, Oregon Health Sciences University, Portland 97201 3098
    J Lipid Res 34:491-9. 1993
    ..Two sterols were identified: cholesterol, 41%, and desmosterol, 59% of total sterols. Desmosterol was found only in the free form...
  10. ncbi Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay
    Hans C Andersson
    Hayward Genetics Center and Department of Pediatrics, Tulane University Medical School, New Orleans, Louisiana 70112, USA
    Am J Med Genet 113:315-9. 2002
    b>Desmosterol (cholesta-5,24-dien-3beta-ol) is a minor sterol that forms as an intermediate in the cholesterol biosynthetic pathway when the 24-unsaturated sterol bond is reduced as the last step rather than earlier in the conversion of ..
  11. ncbi Generation of viable cholesterol-free mice
    A Wechsler
    Quark Biotech, Inc, 10265 Carnegie Avenue, Cleveland, OH 44106, USA
    Science 302:2087. 2003
  12. ncbi Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis
    H R Waterham
    Department of Pediatrics, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Am J Hum Genet 69:685-94. 2001
    ..Patients with desmosterolosis have elevated levels of the cholesterol precursor desmosterol, in plasma, tissue, and cultured cells; this abnormality suggests a deficiency of the enzyme 3beta-..
  13. ncbi Cholesterol synthesis in the vertebrate retina: effects of U18666A on rat retinal structure, photoreceptor membrane assembly, and sterol metabolism and composition
    S J Fliesler
    Saint Louis University Eye Institute, Saint Louis University School of Medicine, Missouri 63104 1540
    Lipids 35:289-96. 2000
    Treatment of neonatal rats with U18666A, an inhibitor of desmosterol delta24-reductase, results in accumulation of desmosterol (delta5,24) and depletion of cholesterol (delta5) in various bodily tissues and also causes cataracts...
  14. ncbi Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol
    Maura Heverin
    Division of Clinical Chemistry, Karolinska University Hospital, Huddinge, S 14186, Sweden
    Arterioscler Thromb Vasc Biol 27:2191-7. 2007
    Characterization of cholesterol homeostasis in male mice with a genetic inactivation of 3beta-hydroxysteroid-delta24-reductase, causing replacement of almost all cholesterol with desmosterol.
  15. ncbi Role of sterol type on lateral pressure profiles of lipid membranes affecting membrane protein functionality: Comparison between cholesterol, desmosterol, 7-dehydrocholesterol and ketosterol
    O H Samuli Ollila
    Institute of Physics, Tampere University of Technology, P O Box 692, FI 33101 Tampere, Finland
    J Struct Biol 159:311-23. 2007
    ..We find that the lateral pressure profile is altered when cholesterol is replaced by either desmosterol, 7-dehydrocholesterol, or ketosterol...
  16. ncbi Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice
    Katrin Kuehnle
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurochem Res 34:1167-82. 2009
    ..DHCR24-knock-out mice lack cholesterol and accumulate desmosterol with age...
  17. ncbi Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands
    Chendong Yang
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Biol Chem 281:27816-26. 2006
    ..the sterol was necessary and sufficient for activity, with the C-24 unsaturated cholesterol precursor sterols desmosterol and zymosterol exerting the largest effects...
  18. ncbi Cholesterol substitution increases the structural heterogeneity of caveolae
    Maurice Jansen
    Institute of Biomedicine Anatomy, University of Helsinki, Helsinki, Finland
    J Biol Chem 283:14610-8. 2008
    ..the structure and function of caveolae, we replaced cholesterol in mammalian cells with its immediate precursor desmosterol by inhibiting 24-dehydrocholesterol reductase...
  19. ncbi Comparison of cholesterol and its direct precursors along the biosynthetic pathway: effects of cholesterol, desmosterol and 7-dehydrocholesterol on saturated and unsaturated lipid bilayers
    Tomasz Rog
    Department of Physics, Helsinki University of Technology, Otakaari 1, F1 02150 Espoo, Finland
    J Chem Phys 129:154508. 2008
    ..Here we elucidate this issue through atomic-scale simulations of desmosterol and 7-dehydrocholesterol (7DHC), which are immediate precursors of cholesterol in its two distinct biosynthetic ..
  20. ncbi Identification of a sterol Delta7 reductase gene involved in desmosterol biosynthesis in Mortierella alpina 1S-4
    Shuo Zhang
    Division of Applied Life of Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwakecho, Sakyo ku, Kyoto 606 8502, Japan
    Appl Environ Microbiol 73:1736-41. 2007
    ..Delta7 reductase from the filamentous fungus Mortierella alpina 1S-4, which accumulates cholesta-5,24-dienol (desmosterol) as the main sterol, revealed that the open reading frame of this gene, designated MoDelta7SR, consists of 1,..
  21. ncbi The distribution of squalene and non-cholesterol sterols in lipoproteins in type 2 diabetes
    Piia P Simonen
    Department of Medicine, Division of Internal Medicine, University of Helsinki, Biomedicum Helsinki, C4 22, P O Box 700, FIN 00029 HUS, Helsinki, Finland
    Atherosclerosis 194:222-9. 2007
    ..Lipoprotein distribution of non-cholesterol sterols was studied to evaluate in which lipoproteins they are carried in type 2 diabetes with body weight ranging from normal to overweight...
  22. ncbi [Synthesis of C24-functionalized hydroxysterols]
    V A Khripach
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, ul Kuprevicha 5 2, Minsk, 220141 Belarus
    Bioorg Khim 28:284-8. 2002
    ..The asymmetric hydroxylation of desmosterol acetate according to Sharpless was used as the key reaction in the stereoselective introduction of ..
  23. ncbi Interaction between cholesterol and glucose metabolism during dietary carbohydrate modification in subjects with the metabolic syndrome
    Maarit Hallikainen
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 84:1385-92. 2006
    ..Carbohydrate modification based on rye bread and pasta enhances early insulin secretion in subjects with the metabolic syndrome...
  24. ncbi Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis
    Françoise Chevy
    INSERM Unité 538, CHU Saint Antoine, 27 rue Chaligny, Paris 75012, France
    J Lipid Res 43:1192-200. 2002
    Triparanol, an inhibitor of desmosterol Delta24 reductase, produces a high rate of limb malformations in rat fetuses exposed at gestational day 10 (gd 10) to a single oral dose (150-200 mg/kg) given to the pregnant dam...
  25. ncbi Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Lipid Res 44:800-6. 2003
    ..Treatment with S-N reduced desmosterol and lathosterol levels (cholesterol synthesis indicators) 46% and 36% (P < 0...
  26. ncbi HPLC method for quantification and characterization of cholesterol and its oxidation products in eggs
    Mônica R Mazalli
    Department of Food Science, Faculty of Food Engineering, State University of Campinas, 13083 862 Campinas, SP, Brazil
    Lipids 41:615-22. 2006
    ..The method showed accuracy and precision with a detection limit between 0.002 and 0.079 microg/g. The oxides cholest-5-ene-3beta,20alpha-diol and cholest-5-ene-3beta,25-diol identified by HPLC-UV-RI were not confirmed by HPLC-APCI-MS...
  27. ncbi A comparison of the behavior of cholesterol and selected derivatives in mixed sterol-phospholipid Langmuir monolayers: a fluorescence microscopy study
    Erin E Berring
    Department of Chemistry, Saint Louis University, Monsanto Hall 125, 3501 Laclede Avenue, St Louis, MO 63103 2010, USA
    Chem Phys Lipids 136:1-12. 2005
    ..In this study, the interactions of CHOL and the related sterols desmosterol (DES) and 7DHC with l-alpha-dipalmitoylphosphatidylcholine (DPPC) monolayers were compared...
  28. ncbi Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations
    Alessandro Pedretti
    Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Facolta di Farmacia, Universita degli Studi di Milano, Via Mangiagalli 25, I 20133 Milano, Italy
    Steroids 73:708-19. 2008
    ..of the enzyme was obtained based on plant Cytokinin Dehydrogenase, and its active site was found to bind the desmosterol plus a set of post-squalenic intermediates of the cholesterol biosynthesis in a binding mode conducive to ..
  29. ncbi Postprandial behavior of plasma squalene and non-cholesterol sterols in men with varying cholesterol absorption
    M Hallikainen
    Department of Clinical Nutrition, University of Kuopio, P O Box 1627, FIN 70211, Kuopio, Finland
    Clin Chim Acta 374:63-8. 2006
    ..lipid clearance (squalene as the surrogate marker) and postprandial cholesterol metabolism evaluated with plasma levels of cholesterol absorption (cholestanol and plant sterols) and synthesis markers (desmosterol and lathosterol).
  30. ncbi DHCR24 gene knockout mice demonstrate lethal dermopathy with differentiation and maturation defects in the epidermis
    Rusella Mirza
    Department of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Chikusa ku, Nagoya, Japan
    J Invest Dermatol 126:638-47. 2006
    ..in the 3beta-hydroxysterol-Delta24 reductase (DHCR24) gene that encodes an enzyme catalyzing the conversion of desmosterol to cholesterol...
  31. ncbi Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor
    Chang Seok Lee
    Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea
    Neuroreport 17:183-7. 2006
    ..Thus, we conclude that it is most likely mediated by liver X receptor/retinoid X receptor heterodimers...
  32. ncbi Analysis of sterols by high-performance liquid chromatography/mass spectrometry combined with chemometrics
    Kornél Nagy
    Department of Mass Spectrometry, Institute of Structural Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri ut 59 67, H 1025 Budapest, Hungary
    Rapid Commun Mass Spectrom 20:2433-40. 2006
    ..plasma concentrations of various phytosterols (cholestanol and beta-sitosterol) and cholesterol metabolites (desmosterol and lathosterol). This was based on an unusual solvent combination of water/methanol vs...
  33. ncbi Alterations of cholesterol synthesis precursors (7-dehydrocholesterol, 7-dehydrodesmosterol, desmosterol) in dysmyelinating neurological mutant mouse (quaking, shiverer and trembler) in the PNS and the CNS
    J M Bourre
    INSERM Unite 26, Hopital Fernand Widal, Paris, France
    Biochim Biophys Acta 1004:387-90. 1989
    In brain, levels of cholesterol, desmosterol and 7-dehydrodesmosterol are reduced in shiverer and quaking, but not in trembler 60-day-old dysmyelinating mutant mice. Very interestingly, 7-dehydrocholesterol is not altered in any mutant...
  34. ncbi On the role of liver X receptors in lipid accumulation in adipocytes
    Lene K Juvet
    Institute for Nutrition Research, University of Oslo, N 0316 Oslo, Norway
    Mol Endocrinol 17:172-82. 2003
    ..These findings imply a role for LXR in controlling lipid storage capacity in mature adipocytes and point to an intriguing physiological interplay between LXR and PPARgamma in controlling pathways in lipid handling...
  35. ncbi Fatty acid and sterol composition of frozen and freeze-dried New Zealand Green Lipped Mussel (Perna canaliculus) from three sites in New Zealand
    Karen J Murphy
    Department of Food Science, RMIT University, Melbourne, Australia
    Asia Pac J Clin Nutr 12:50-60. 2003
    ..Cholesterol was the most prominent sterol (31% of total sterols). Other major sterols included desmosterol/brassicasterol (co-eluting), 24-methylenecholesterol, trans-22-dehydrocholesterol, 24-nordehydrocholesterol and ..
  36. ncbi Effects of ezetimibe, simvastatin, atorvastatin, and ezetimibe-statin therapies on non-cholesterol sterols in patients with primary hypercholesterolemia
    Gerd Assmann
    Leibniz Institute of Arteriosclerosis Research at the University of Münster, and Institute for Clinical Chemistry and Laboratory Medicine, University Clinics Münster, Munster, Germany
    Curr Med Res Opin 24:249-59. 2008
    ..g., desmosterol, lathosterol) and their ratios to TC correlate with cholesterol biosynthesis...
  37. ncbi [Factors modulating parameters of cholesterol homeostasis in the metabolic syndrome]
    A Zak
    IV interní klinika 1, LF UK a VFN, Praha
    Cas Lek Cesk 146:357-66. 2007
    ..The concentrations of cholesterol precursors (lathosterol, desmosterol, respectively their rations to cholesterol) are related to the synthesis of cholesterol; concentrations of ..
  38. ncbi Effect of chemical carcinogens on cholesterol biosynthetic pathways in the skin of mice
    Y Tanimoto
    Department of Oral and Maxillofacial Surgery I, Hiroshima University, School of Dentistry, Japan
    Carcinogenesis 11:1647-51. 1990
    ..mouse skin only lathosterol was a major metabolite and the other metabolites, cholesta-5,7,24-trien-3 beta-ol, desmosterol, cholesterol and 7-dehydrocholesterol were much less abundant...
  39. ncbi Quantitative analysis of five sterols in amniotic fluid by GC-MS: application to the diagnosis of cholesterol biosynthesis defects
    C Amaral
    Departamento de Quimica, Universidade da Beira Interior, Rua Marques d Avila e Bolama, 6200 001 Covilhã, Portugal
    J Chromatogr B Analyt Technol Biomed Life Sci 878:2130-6. 2010
    Cholesterol and its precursors, namely 7-dehydrocholesterol, desmosterol and lathosterol are important biochemical markers of cholesterol biosynthesis, and their quantification in body fluids is useful for the diagnosis of cholesterol ..
  40. ncbi Twenty-one year tracking of serum non-cholesterol sterols. The Cardiovascular Risk in Young Finns study
    T A Miettinen
    Department of Medicine, Division of Internal Medicine, University of Helsinki, Biomedicum Helsinki, room C4 22, P O Box 700, FIN 00029 HUS, Finland
    Nutr Metab Cardiovasc Dis 19:525-31. 2009
    To show tracking of cholesterol metabolism, the ratios to cholesterol of e.g. serum cholestenol, desmosterol, and lathosterol, reflecting cholesterol synthesis, and cholestanol, campesterol, avenasterol and sitosterol, reflecting ..
  41. ncbi Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment
    T A Miettinen
    University of Helsinki, Helsinki, Finland
    Eur J Clin Invest 33:976-82. 2003
    ..Serum contains noncholesterol sterols, which are reliable markers of cholesterol metabolism, but their presence and importance in different lipoproteins have been insufficiently studied...
  42. ncbi Seasonal and geographical variations of sterol composition in snow crab hepatopancreas and pelagic fish viscera from Eastern Quebec
    Nathalie Souchet
    Departement de Biologie, chimie et géographie, Universite du Quebec a Rimouski, Rimouski, Quebec, Canada
    Comp Biochem Physiol B Biochem Mol Biol 147:378-86. 2007
    ..25 mg/100 g wet basis for cholesterol and desmosterol; 0.03-0.05 mg/100 g for other sterols), good reproducibility (CV%: 1.5-6.8) and accuracy (recovery%: 94-107)...
  43. ncbi Effects of calcium and plant sterols on serum lipids in obese Zucker rats on a low-fat diet
    Timo Vaskonen
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    Br J Nutr 87:239-45. 2002
    ..913, P<0.001, n 18), whereas serum desmosterol: cholesterol and lathosterol: cholesterol indicated that Ca dose-dependently increased endogenous cholesterol ..
  44. ncbi Progestins block cholesterol synthesis to produce meiosis-activating sterols
    B Lindenthal
    Department of Physiology and Experimental Medicine, The George Washington University School of Medical and Health Sciences, Washington, DC 20037, USA
    FASEB J 15:775-84. 2001
    ..were potent inhibitors of Delta24-reduction in an in vitro cell assay and led to the accumulation of desmosterol, a Delta5,24 sterol precursor of cholesterol...
  45. ncbi Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells
    Ying Liu
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, 3900 Reservoir Road Northwest, Washington, D C 20057, USA
    Mol Endocrinol 19:1918-31. 2005
    ..substrates indicated that unlike squalene, addition of squalene epoxide, lanosterol, zymosterol, and desmosterol could rescue the hormone-induced progesterone formation...
  46. ncbi Phytosterol biosynthesis pathway in Mortierella alpina
    W David Nes
    Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409 1061, USA
    Phytochemistry 67:1716-21. 2006
    ..The principal sterol of the mycelium was cholesta-5, 24-dienol (desmosterol) (83%), with lesser amounts of 24beta-methyl-cholesta-5,25(27)-dienol (codisterol) (2%), 24-methyldesmosterol (..
  47. ncbi Serum plant and other noncholesterol sterols, cholesterol metabolism and 22-year mortality among middle-aged men
    Timo E Strandberg
    Institute of Health Sciences Geriatrics, University of Oulu, and Oulu University Hospital, Unit of General Practice, PO Box 5000, FIN 90014, Oulu, Finland
    Atherosclerosis 210:282-7. 2010
    ..To evaluate long-term prognostic effect of serum noncholesterol sterols, including plant sterols, in middle-aged men with high cardiovascular disease (CVD) risk, without statins at baseline...
  48. ncbi Interannual and between species comparison of the lipids, fatty acids and sterols of Antarctic krill from the US AMLR Elephant Island survey area
    Charles F Phleger
    Department of Biology, San Diego State University, San Diego, CA 92182, USA
    Comp Biochem Physiol B Biochem Mol Biol 131:733-47. 2002
    ..tricantha. Cholesterol was the major sterol (80-100% of total sterols) with desmosterol second in abundance (1-18%). 1997 T. macrura and E...
  49. ncbi Expression of the novel adrenocorticotropin-responsive gene selective Alzheimer's disease indicator-1 in the normal adrenal cortex and in adrenocortical adenomas and carcinomas
    Paola Luciani
    Endocrine Unit, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
    J Clin Endocrinol Metab 89:1332-9. 2004
    ..This gene encodes 3-beta-hydroxysterol Delta-24-reductase (DHCR24), which converts desmosterol into cholesterol...
  50. ncbi Specificity of the commonly used enzymatic assay for plasma cholesterol determination
    M H Moghadasian
    Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, Canada
    J Clin Pathol 55:859-61. 2002
    ..To assess the specificity and sensitivity of the commonly used enzymatic colorimetric test for plasma cholesterol determination...
  51. ncbi Changes in cholesterol biosynthetic and transport pathways after excitotoxicity
    Ji Hyun Kim
    Department of Anatomy, National University of Singapore, Singapore
    J Neurochem 112:34-41. 2010
    ..GC-MS analyses showed a significant increase in cholesterol biosynthetic precursors lanosterol, desmosterol and 7-dehydrocholesterol at 1 day after kainate injection presumably reflecting biosysnthesis in injured ..
  52. ncbi Lipid, FA, and sterol composition of New Zealand green lipped mussel (Perna canaliculus) and Tasmanian blue mussel (Mytilus edulis)
    Karen J Murphy
    RMIT University, Melbourne, Victoria, Australia
    Lipids 37:587-95. 2002
    ..Other major sterols included brassicasterol, 22-methylcholesterol, trans-22-dehydrocholesterol, and desmosterol. There were significant differences (P < 0.05) between the NZGLM and TBM for 12 of the 20 sterols measured...
  53. ncbi Subcellular organelle lipidomics in TLR-4-activated macrophages
    Alexander Y Andreyev
    Department of Chemistry and Biochemistry and Department of Pharmacology, University of California, San Diego, CA 92093, USA
    J Lipid Res 51:2785-97. 2010
    ..g., increases in the levels of ceramides and the cholesterol precursors desmosterol and lanosterol). Other changes were manifest in specific organelles...
  54. ncbi Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8
    Knut E Berge
    The Department of Molecular Genetics, UT Southwestern Medical Center, Dallas, TX 75390 9052, USA
    J Lipid Res 43:486-94. 2002
    ..derivative of cholesterol (cholestanol), two precursors in the cholesterol biosynthesis pathway (desmosterol and lathosterol), and two phytosterols (campesterol and sitosterol)...
  55. ncbi Oxysteroids: a new class of steroids with autocrine and paracrine functions
    Norman B Javitt
    Dept of Pediatrics and Medicine, NYU School of Medicine, New York, N Y 10016, USA
    Trends Endocrinol Metab 15:393-7. 2004
    ..An additional three oxysteroids, the 25,26-hydroxy derivatives of lanosterol, zymosterol, and desmosterol, respectively, were generated in vitro by CYP27A1-transfected bacteria...
  56. ncbi Increased expression of aquaporin-3 in the epidermis of DHCR24 knockout mice
    R Mirza
    Division of Stress Recognition and Response, Department of Endocrinology, Research Institute of Environmental Medicine, Nagoya University, Furo cho, Chikusa ku, Nagoya, Japan
    Br J Dermatol 158:679-84. 2008
    The DHCR24 (3beta-hydroxysterol-Delta24 reductase) gene encodes an enzyme catalysing conversion of desmosterol to cholesterol...
  57. ncbi Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis
    Klementina Fon Tacer
    Center for Functional Genomic and Biochips, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Zaloska 4, SI 1000 Ljubljana, Slovenia
    J Steroid Biochem Mol Biol 121:619-25. 2010
    ..5% in the liver, 1% in brain and 5% in testis. In the liver only 7-dehydrocholesterol, lanosterol and desmosterol were detected...
  58. ncbi DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling
    Xiuli Lu
    Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464 8601, Japan
    Endocrinology 147:3123-32. 2006
    The DHCR24 gene encodes an enzyme catalyzing the last step of cholesterol biosynthesis, the conversion of desmosterol to cholesterol...
  59. ncbi Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity
    Helena Gylling
    Department of Clinical Nutrition, University of Kuopio, Kuopio University Hospital, Kuopio, Finland
    J Lipid Res 45:1660-5. 2004
    ..index (BMI), plasma glucose, serum insulin and triglycerides, and cholesterol synthesis markers (cholestenol, desmosterol, lathosterol) and low HDL cholesterol and cholesterol absorption markers (campesterol, sitosterol) (P < 0...
  60. ncbi Secretion of sterols and the NPC2 protein from primary astrocytes
    Aino Liisa Mutka
    Institute of Biotechnology, University of Helsinki, Viikinkaari 9, 00014 University of Helsinki, Finland
    J Biol Chem 279:48654-62. 2004
    ..murine embryonic astrocytes secrete endogenously synthesized cholesterol but also the cholesterol precursors desmosterol and lathosterol. In astrocyte membranes, desmosterol and cholesterol were the predominant sterols...
  61. ncbi Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse
    Curzio Solcà
    Division of Endocrinology, Metabolism and Clinical Nutrition, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Genet Metab 91:7-14. 2007
    ..mutations in the enzyme 3ss-hydroxysterol Delta7 reductase (Dhcr7) lead to a failure of cholesterol (and desmosterol) synthesis, with an accumulation of precursor sterols, such as 7-dehydrocholesterol...
  62. ncbi Interannual variations in the lipids of the Antarctic pteropods Clione limacina and Clio pyramidata
    C F Phleger
    Department of Biology, San Diego State University, San Diego, CA 92182, USA
    Comp Biochem Physiol B Biochem Mol Biol 128:553-64. 2001
    ..of both pteropods included trans-dehydrocholesterol, brassicasterol, 24-methylenecholesterol, cholesterol and desmosterol. Levels of 24-methylenecholesterol and desmosterol were lower in both pteropods in 1997 compared to 1998. C...
  63. ncbi Synthesis and in vitro biological activity of 4alpha-(2-propenyl)-5alpha-cholest-24-en-3alpha-ol: a 24,25-dehydro analog of the hypocholesterolemic agent 4alpha-(2-propenyl)-5alpha-cholestan-3alpha-ol
    H S Lin
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Steroids 64:217-27. 1999
    ..To investigate the effect of the 24,25-unsaturation in the D-ring side chain (desmosterol D-ring side chain) on antagonizing the repressing effect of 25-hydroxycholesterol, 4alpha-(2-propenyl)-5alpha-..
  64. ncbi Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells
    Jure Acimovic
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2081-6. 2009
    ..allowing quantitative analysis of 11 structurally similar cholesterol precursors and plant sterols (squalene, desmosterol, 7-dehydrocholesterol, lathosterol, zymosterol, dihydro-lanosterol, lanosterol, FF-MAS, T-MAS, campesterol, ..
  65. ncbi Seladin-1 is a fundamental mediator of the neuroprotective effects of estrogen in human neuroblast long-term cell cultures
    Paola Luciani
    Endocrine Unit, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, University of Florence, Florence, Italy
    Endocrinology 149:4256-66. 2008
    ..seladin-1 gene encodes 3beta-hydroxysterol Delta24-reductase, which catalyzes the synthesis of cholesterol from desmosterol. We have demonstrated previously that in fetal neuroepithelial cells, 17beta-estradiol (17betaE2), raloxifene, ..
  66. ncbi Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding
    Jussi Pihlajamaki
    Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
    Metabolism 59:866-72. 2010
    ..Serum markers of cholesterol synthesis (cholestenol, desmosterol, and lathosterol) and cholesterol absorption (campesterol, sitosterol, avenasterol, and cholestanol) were ..
  67. ncbi Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain
    Dieter Lutjohann
    Department of Clinical Pharmacology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Lipid Res 43:1078-85. 2002
    ..the sterols measured, lanosterol is the first common intermediate of two different pathways, which use either desmosterol or lathosterol as the predominant precursors for de novo synthesis of brain cholesterol...
  68. ncbi Recent insights into the Smith-Lemli-Opitz syndrome
    H Yu
    Division of Endocrinology, Metabolism and Nutrition, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Clin Genet 68:383-91. 2005
    ..DHCR7 deficiency impairs both cholesterol and desmosterol production, resulting in elevated 7DHC/8DHC levels, typically decreased cholesterol levels and, importantly, ..
  69. ncbi Decrease in order of human sperm lipids during capacitation
    Nicholas L Cross
    Department of Physiological Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Biol Reprod 69:529-34. 2003
    ..Loss of the sperm sterols, cholesterol and desmosterol, is an obligatory step in the capacitation of human sperm...
  70. ncbi Sperm membrane fatty acid composition in the Eastern grey kangaroo (Macropus giganteus), koala (Phascolarctos cinereus), and common wombat (Vombatus ursinus) and its relationship to cold shock injury and cryopreservation success
    R R Miller
    Biology Department, Hillsdale College, Hillsdale, MI, USA
    Cryobiology 49:137-48. 2004
    ..While species-related differences in membrane sterol levels (cholesterol and desmosterol) were observed in cauda epididymidal spermatozoa, marsupial membrane sterol levels are very low...
  71. ncbi Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men
    Jussi Pihlajamaki
    Department of Medicine, University of Kuopio, Kuopio, Finland
    J Lipid Res 45:507-12. 2004
    ..05). Fasting insulin correlated with desmosterol (r = 0.286, P = 0.015) and lathosterol (r = 0.248, P = 0...
  72. ncbi Reductions in cholesterol and synaptic markers in association cortex in mood disorders
    Clare L Beasley
    Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Bipolar Disord 7:449-55. 2005
    ..The aim of this study was to quantify sterol levels in the brains of patients with major psychiatric disorders and further to relate these levels to markers of myelin and synapses...
  73. ncbi SREBP-1c gene polymorphism is associated with increased inhibition of cholesterol-absorption in response to ezetimibe treatment
    H K Berthold
    Medical Faculty of the University of Bonn, Clinical Pharmacology, Bonn, Germany
    Exp Clin Endocrinol Diabetes 116:262-7. 2008
    ....
  74. ncbi Cholesterol absorption and synthesis in pediatric kidney, liver, and heart transplant recipients
    Arja Siirtola
    Pediatric Research Center, University of Tampere, Tampere, Finland
    Transplantation 81:327-34. 2006
    ..To find an explanation to the observed difference, our kidney recipients' cholesterol synthesis and absorption efficiency was compared to those of liver and heart recipients...
  75. ncbi Regulation of cholesterol 25-hydroxylase expression by vitamin D3 metabolites in human prostate stromal cells
    Jing Huan Wang
    Department of Anatomy, Medical School, 33014 University of Tampere, Tampere, Finland
    Biochem Biophys Res Commun 345:720-5. 2006
    ..25-Hydroxycholesterol significantly decreased the P29SN cell number. A CH25H enzyme inhibitor, desmosterol, increases basal cell number but has no significant effect on vitamin D3 treated cells...
  76. ncbi The cholesterol storage disorder of the mutant BALB/c mouse. A primary genetic lesion closely linked to defective esterification of exogenously derived cholesterol and its relationship to human type C Niemann-Pick disease
    P G Pentchev
    J Biol Chem 261:2772-7. 1986
    ..Homozygous-affected fibroblasts took up and converted [3H]desmosterol to [3H]cholesterol at a normal rate indicating that the murine mutation does not compromise the transport of ..
  77. ncbi Alteration of cholesterol biosynthetic pathways in the skin of mice administered polycyclic aromatic hydrocarbons
    K Fukao
    Department of Oral and Maxillofacial Surgery I, Hiroshima University, School of Dentistry, Japan
    Cancer Res 48:2555-60. 1988
    ..When diazacholesterol (a metabolic inhibitor) was administered to mice, both desmosterol and 5 alpha-cholesta-7,24-dien-3 beta-ol accumulated in the skin, whereas the level of lathosterol decreased...
  78. ncbi Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1
    Susanna Benvenuti
    Endocrine Unit, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
    Exp Cell Res 312:2592-604. 2006
    ..In addition, seladin-1 catalyzes the conversion of desmosterol into cholesterol...
  79. ncbi [Seladin-1/DHCR24: a key protein of cell homeostasis and cholesterol biosynthesis]
    Joanna Drzewinska
    Katedra Biofizyki Molekularnej, Uniwersytet Łódzki, 90 237 Łódź
    Postepy Hig Med Dosw (Online) 63:318-30. 2009
    ..of DHCR24 gene result in inhibition of the enzymatic activity of seladin-1, causing an accumulation of desmosterol and leading to a lethal disorder called desmosterolosis...
  80. ncbi Differential effects of cholesterol and its immediate biosynthetic precursors on membrane organization
    Sandeep Shrivastava
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
    Biochemistry 47:5668-77. 2008
    ..7-Dehydrocholesterol (7-DHC) and desmosterol are the immediate biosynthetic precursors of cholesterol in the Kandutsch-Russell and Bloch pathway...
  81. ncbi Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease
    Tim Vanmierlo
    Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Alzheimers Dis 19:117-27. 2010
    ..age of 9 months when AD-like pathology starts to develop, display increased levels of the cholesterol precursor desmosterol and of the cholesterol metabolite 27-hydroxy(OH)cholesterol in their cerebellum in comparison with wild-type ..
  82. ncbi Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes
    Yoshihiko Ohyama
    Divisions of Clinical Chemistry and Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Biol Chem 281:3810-20. 2006
    ..in vivo in a sterol-deficient mouse model (Dhcr24 null) in which almost all cholesterol had been replaced with desmosterol, which is not a substrate for CYP46A1...
  83. ncbi New insights on the neuroprotective role of sterols and sex steroids: the seladin-1/DHCR24 paradigm
    Alessandro Peri
    Department of Clinical Physiopathology, Endocrine Unit, Center for Research, University of Florence, Florence, Italy
    Front Neuroendocrinol 30:119-29. 2009
    ..that encodes 3-beta-hydroxysterol delta-24-reductase (DHCR24), that catalyzes the synthesis of cholesterol from desmosterol. There is evidence that cholesterol plays a fundamental role in maintaining brain homeostasis...
  84. ncbi Apolipoprotein E phenotype regulates cholesterol absorption in healthy 13-month-old children--The STRIP Study
    A Tammi
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Pediatr Res 50:688-91. 2001
    ..early childhood, we measured serum plant sterol (campesterol and sitosterol) and cholesterol precursor sterol (desmosterol and lathosterol) concentrations in healthy 13-month old children using gas-liquid chromatography...
  85. ncbi Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation
    Ofir Levi
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    J Neurochem 95:987-97. 2005
    ..In contrast, the hippocampal levels of cholesterol and its precursors lathosterol and desmosterol and metabolite 24S-hydroxycholesterol were lower in apoE-deficient mice that were maintained in a regular ..
  86. ncbi The reduced form of coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice
    Constance Schmelzer
    Department of Molecular Prevention, Institute of Human Nutrition and Food Science, Molecular Prevention, Christian Albrechts University of Kiel, Kiel, Germany
    IUBMB Life 62:812-8. 2010
    ..We found a significant increase of desmosterol (2.0-fold, P < 0.001) in the liver of ubiquinol-supplemented SAMP1 mice when related to control animals...
  87. ncbi Polymorphism of the hepatic influx transporter organic anion transporting polypeptide 1B1 is associated with increased cholesterol synthesis rate
    Marja K Pasanen
    Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Pharmacogenet Genomics 18:921-6. 2008
    ..The mean fasting baseline plasma desmosterol to cholesterol ratio was 40% higher in participants with the SLCO1B1 c...
  88. ncbi Lipids and buoyancy in Southern ocean pteropods
    C F Phleger
    Department of Biology, San Diego State University, California 92182, USA
    Lipids 32:1093-100. 1997
    ..as are the sterols, which include 24-methylenecholesterol, transdehydrocholesterol, cholesterol, and desmosterol. This finding probably reflects the fact that Limacina is the major food source for Clione...
  89. ncbi Discovering oxysterols in plasma: a window on the metabolome
    William J Griffiths
    Institute of Mass Spectrometry, School of Medicine, Grove Building, Swansea University, Singleton Park, Swansea, UK
    J Proteome Res 7:3602-12. 2008
    ..is also applicable for the analysis of other sterols in plasma, that is, cholesterol, 7-dehydrocholesterol, and desmosterol, as well as cholesterol 5,6- seco-sterols and steroid hormones...
  90. ncbi Neuroprotective effects of the Alzheimer's disease-related gene seladin-1
    Alessandro Peri
    Endocrine Unit, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
    J Mol Endocrinol 41:251-61. 2008
    ..gene encodes 3-beta-hydroxysterol Delta-24-reductase, which catalyzes the synthesis of cholesterol from desmosterol. In recent years, it has been demonstrated that an appropriate amount of membrane cholesterol determines the ..
  91. ncbi Formal synthesis of squalamine from desmosterol
    Kazuo Okumura
    Niigata University of Pharmacy and Applied Life Sciences, Japan
    Chem Pharm Bull (Tokyo) 51:1177-82. 2003
    ..was synthesized from the 3-O-acetyl-24R,25-dihydroxy derivative of desmosterol via 10 steps in 16% overall yield and squalamine was also prepared via two further steps in 7...
  92. ncbi Cytotoxic oxygenated desmosterols of the red alga Galaxaura marginata
    J H Sheu
    Department of Marine Resources, National Sun Yat Sen University, Taiwan, Republic of China
    J Nat Prod 59:23-6. 1996
    b>Desmosterol (1), 24,25-epoxycholesterol (2), 24-hydroperoxycholesta-5,25-dien-3 beta-ol (3), 25-hydroperoxycholesta-5,23(E)-dien-3 beta-ol (4), cholesta-5,25-diene-3 beta,24-diol (5), and 24,25-epoxy-6 beta-hydroxycholest-4-en-3-one (7) ..
  93. ncbi Separation and determination of diversiform phytosterols in food materials using supercritical carbon dioxide extraction and ultraperformance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry
    Baiyi Lu
    Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310029, Zhejiang Province, PR China
    Anal Chim Acta 588:50-63. 2007
    ..0205, 0.0225, 0.3674, 0.0241, 0.0272, 0.0076 microg L(-1) and 0.1525 microg mL(-1) for 6-ketocholestanol, desmosterol, ergosterol, cholesterol, lanosterol, cholestanol, campesterol, stigmasterol, beta-sitosterol, and stigmastanol,..
  94. ncbi Stereochemistry of the reduction of 24-ethyldesmosterol to sitosterol in tissue cultures of Oryza sativa
    Y Fujimoto
    Department of Chemistry, Tokyo Institute of Technology, Japan
    Bioorg Med Chem Lett 8:205-8. 1998
    ....
  95. ncbi Identification of cholesta-7,24-dien-3 beta-ol and desmosterol in hamster cauda epididymal spermatozoa
    M Awano
    Department of Biology, College of Arts and Sciences, University of Tokyo, Japan
    Lipids 24:662-4. 1989
    ..b>Desmosterol and cholesta-7,24-dien-3 beta-ol account for as much as 90% of the total sterols...
  96. ncbi Cholesterol efflux-mediated signal transduction in mammalian sperm: cholesterol release signals an increase in protein tyrosine phosphorylation during mouse sperm capacitation
    P E Visconti
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6080, USA
    Dev Biol 214:429-43. 1999
    ....
  97. ncbi Cholesterol synthesis is associated with hepatic lipid content and dependent on fructose/glucose intake in healthy humans
    Guenther Silbernagel
    Division of Endocrinology, Department of Internal Medicine, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Eberhard Karls University Tubingen, Otfried Müller Straße 10, 72076 Tubingen, Germany
    Exp Diabetes Res 2012:361863. 2012
    ..Performing cross-sectional analyses the lanosterol and desmosterol to cholesterol ratios were positively correlated with visceral and liver fat content (all P < .03)...
  98. ncbi Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol
    Thomas Pfeifer
    Institute of Molecular Biology and Biochemistry, Medical University of Graz, Harrachgasse 21 3, Graz, Austria
    Curr Pharm Biotechnol 12:285-92. 2011
    ..this study is that DMHCA inhibited the enzyme 3β-hydroxysterol-Δ24-reductase resulting in an accumulation of desmosterol in the plasma and in feces...
  99. ncbi Separation of 24- and 25-dehydrocholesterols; and the impure state of commercial desmosterol preparations
    J A Svoboda
    Insect Physiology Laboratory, Entomology Research Division, Agricultural Research Service, US Department of Agriculture, Beltsville, Maryland 20705, USA
    J Lipid Res 8:152-4. 1967
    ....
  100. ncbi Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD
    Nirupa R Matthan
    Cardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 50:1927-35. 2009
    ..138 +/- 3, 73 +/- 3 vs. 75 +/- 2 for lathosterol and desmosterol, respectively) in cases compared with controls, irrespective of sex...
  101. ncbi Atorvastatin in patients with primary biliary cirrhosis and incomplete biochemical response to ursodeoxycholic acid
    Tatjana Stojakovic
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
    Hepatology 46:776-84. 2007
    ..001). Precursors of cholesterol biosynthesis (lanosterol, desmosterol, lathosterol) showed a similar pattern...

Research Grants23

  1. REGULATION OF SPERM EXOCYTOSIS
    Nicholas Cross; Fiscal Year: 2002
    ..The cholesterol content of freshly ejaculated and oviductal bovine sperm will be compared to see if sperm lose cholesterol in the female tract. ..
  2. APOLIPOPROTEIN ISOFORMS AND RETINAL DEGENERATION
    STEVEN FLIESLER; Fiscal Year: 2007
    ....
  3. Significance of CYP46A1 and other P450s in retinal function
    Irina Pikuleva; Fiscal Year: 2007
    ..Relevance (for lay audience). This research will be critical for understanding the development of certain eye diseases that reduce vision. ..
  4. Cholesterol-metabolizing P450s and Alzheimer's disease
    Irina Pikuleva; Fiscal Year: 2007
    ..If funded, the release time and salary support will significantly enhance the P.I.'s career in basic science research and make it more medically oriented. ..
  5. Enzyme Targets-Sterol Synthesis-Opportunistic Pathogens
    WILLIAM NES; Fiscal Year: 2004
    ..The results from these studies will facilitate the design of therapeutic strategies aimed to provide species-specific discrimination of inhibition in the ergosterol biosynthetic pathway. ..