Genomes and Genes
Summary: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Publications293 found, 100 shown here
- Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditionsAngel Catala
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas INIFTA CCT La Plata CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CC 16, Sucursal 4, 1900 La Plata, Argentina
Chem Phys Lipids 157:1-11. 2009..These aldehydes exhibit great reactivity with biomolecules, such as proteins, DNA, and phospholipids, generating a variety of intra and intermolecular covalent adducts...
- Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometryX Han
Division of Bioorganic Chemistry, Department of Internal Medicine, Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri, USA
J Neurochem 77:1168-80. 2001....
- The exceptional longevity of an egg-laying mammal, the short-beaked echidna (Tachyglossus aculeatus) is associated with peroxidation-resistant membrane compositionA J Hulbert
Metabolic Research Centre and School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia
Exp Gerontol 43:729-33. 2008..b>Phospholipids were extracted from skeletal muscle, liver and liver mitochondria of echidnas and fatty acid composition ..
- Profiling membrane lipids in plant stress responses. Role of phospholipase D alpha in freezing-induced lipid changes in ArabidopsisRuth Welti
Division of Biology, Ackert Hall, Kansas State University, Manhattan, Kansas 66506, USA
J Biol Chem 277:31994-2002. 2002....
- Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intakeLeanne Hodson
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK
Prog Lipid Res 47:348-80. 2008..The relationship between plasma lipoprotein concentrations and total plasma fatty acid composition, and the use of fatty acid ratios as indices of enzyme activity are also addressed...
- Making heads or tails of phospholipids in mitochondriaChristof Osman
Institute for Genetics, Centre for Molecular Medicine, Cologne Excellence Cluster Cellular Stress Responses in Aging Associated Diseases, University of Cologne, Cologne, Germany
J Cell Biol 192:7-16. 2011Mitochondria are dynamic organelles whose functional integrity requires a coordinated supply of proteins and phospholipids. Defined functions of specific phospholipids, like the mitochondrial signature lipid cardiolipin, are emerging in ..
- Fish oil supplementation alters the plasma lipidomic profile and increases long-chain PUFAs of phospholipids and triglycerides in healthy subjectsInger Ottestad
Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Oslo, Norway
PLoS ONE 7:e42550. 2012..The aim of this study was to investigate the effect of fish oil supplementation on the plasma lipidomic profile in healthy subjects...
- Membrane lipid homeostasis in bacteriaYong Mei Zhang
Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, Tennessee 38105, USA
Nat Rev Microbiol 6:222-33. 2008The ability of bacteria to control the biophysical properties of their membrane phospholipids allows them to thrive in a wide range of physical environments...
- An ER-mitochondria tethering complex revealed by a synthetic biology screenBenoît Kornmann
Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94158, USA
Science 325:477-81. 2009..The tethering complex localized to discrete foci, suggesting that discrete sites of close apposition between ER and mitochondria facilitate interorganelle calcium and phospholipid exchange...
- Fatty acids measured in plasma and erythrocyte-membrane phospholipids and derived by food-frequency questionnaire and the risk of new-onset type 2 diabetes: a pilot study in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cPinal S Patel
Medical Research Council Epidemiology Unit, Cambridge, United Kingdom
Am J Clin Nutr 92:1214-22. 2010..Epidemiologic evidence for the association between types of fatty acid and risk of type 2 diabetes is inconsistent. This may in part be due to the limitations of fatty acid measurement methods...
- Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-β-1,6-N-acetylglucosamineRebekah Henry
Department of Microbiology, Monash University, Clayton, Australia
Antimicrob Agents Chemother 56:59-69. 2012..Taken together, these data show that, in response to total LPS loss, A. baumannii alters the expression of critical transport and biosynthesis systems associated with modulating the composition and structure of the bacterial surface...
- Changes in electric charge and phospholipids composition in human colorectal cancer cellsIzabela Dobrzynska
Institute of Chemistry, University in Białystok, Al Piłsudskiego 11 4, Białystok, Poland
Mol Cell Biochem 276:113-9. 2005..This work is focused on changes of phospholipids content (PI-phosphatidylinositol, PS-phosphatidylserine, PE-phosphatidylethanolamine, PC-phosphatidylcholine) ..
- The surface of lipid droplets is a phospholipid monolayer with a unique Fatty Acid compositionKumi Tauchi-Sato
Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Japan
J Biol Chem 277:44507-12. 2002..was observed as a single line without any fixation or staining, indicating the presence of a single layer of phospholipids. This result appeared consistent with the hypothesis that the lipid droplet surface is derived from the ..
- Identification of a physiologically relevant endogenous ligand for PPARalpha in liverManu V Chakravarthy
Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Avenue, St Louis, MO 63110, USA
Cell 138:476-88. 2009..Portal vein infusion of 16:0/18:1-GPC induced PPARalpha-dependent gene expression and decreased hepatic steatosis. These data suggest that 16:0/18:1-GPC is a physiologically relevant endogenous PPARalpha ligand...
- Role of phospholipids in endocytosis, phagocytosis, and macropinocytosisMichal Bohdanowicz
Division of Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, Canada
Physiol Rev 93:69-106. 2013..over many years to understanding the proteins involved in these processes, the important contribution of phospholipids has only recently been appreciated...
- Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoidsMartin Rossmeisl
Department of Adipose Tissue Biology, Institute of Physiology Academy of Sciences of the Czech Republic v v i, Prague, Czech Republic
PLoS ONE 7:e38834. 2012..We hypothesised that the latter effect will be more pronounced when DHA/EPA is supplemented as phospholipids rather than as triglycerides.
- The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipidsD Liu
Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555 0653, USA
FASEB J 13:2318-28. 1999..Liu, D., Wen, J., Liu, J., Li, L. The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids.
- Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU StudyB Vessby
Unit for Clinical Nutrition Research, Department of Public Health and Caring Sciences/Geriatrics, University of Uppsala, Uppsala, Sweden
Diabetologia 44:312-9. 2001..A beneficial impact of the fat quality on insulin sensitivity is not seen in individuals with a high fat intake (> 37E%)...
- Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitroNataliya A Pidkovka
University of Virginia, Cardiovascular Research Center, Department of Molecular Physiology and Biophysics, 415 Lane Road, Charlottesville, VA 22908, USA
Circ Res 101:792-801. 2007..Oxidized phospholipids (oxPLs), such as 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) and its constituents 1-..
- Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) StudyLu Wang
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
Am J Clin Nutr 78:91-8. 2003..The results of some epidemiologic studies conducted by using questionnaires suggest that dietary fat composition influences diabetes risk. Confirmation of this finding with use of a biomarker is warranted...
- Phospholipids undergo hop diffusion in compartmentalized cell membraneTakahiro Fujiwara
Kusumi Membrane Organizer Project, Exploratory Research for Advanced Technology Organization, Japan Science and Technology Corporation, Nagoya 460 0012, Japan
J Cell Biol 157:1071-81. 2002..Here we address this issue by studying the movement of unsaturated phospholipids in rat kidney fibroblasts at the single molecule level at the temporal resolution of 25 micros...
- Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipidsLinda Schaeffer
GSF National Research Center for Environment and Health, Institute of Epidemiology, 85764 Neuherberg, Germany
Hum Mol Genet 15:1745-56. 2006..variants in the human delta-5 and delta-6 desaturase genes FADS1 FADS2 and fatty acid composition in serum phospholipids. Eighteen polymorphisms located in this gene cluster were genotyped in 727 adults from Erfurt, a German centre ..
- Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolasesDiana M Stafforini
Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112 5550, USA
J Biol Chem 281:4616-23. 2006F2-isoprostanes are produced in vivo by nonenzymatic peroxidation of arachidonic acid esterified in phospholipids. Increased urinary and plasma F2-isoprostane levels are associated with a number of human diseases...
- Plasma phospholipids identify antecedent memory impairment in older adultsMark Mapstone
Department of Neurology, University of Rochester School of Medicine, Rochester, New York, USA
Nat Med 20:415-8. 2014..This biomarker panel, reflecting cell membrane integrity, may be sensitive to early neurodegeneration of preclinical Alzheimer's disease. ..
- Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2Alexandra Kadl
Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
Circ Res 107:737-46. 2010..In atherosclerosis, oxidative tissue damage accompanies chronic inflammation; however, macrophage phenotypic changes in response to oxidatively modified molecules are not known...
- The safety of Sonovue in abdominal applications: retrospective analysis of 23188 investigationsFabio Piscaglia
Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
Ultrasound Med Biol 32:1369-75. 2006....
- Generation and biological activities of oxidized phospholipidsValery N Bochkov
Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
Antioxid Redox Signal 12:1009-59. 2010..Oxidation of esterified unsaturated fatty acids dramatically changes biological activities of phospholipids. Apart from impairment of their structural function, oxidation makes oxidized phospholipids (OxPLs) markers of ..
- Mechanisms of phospholipid complex loaded nanoparticles enhancing the oral bioavailabilityQiang Peng
Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Southern Renmin Road, No 17, Section 3, Chengdu 610041, P R China
Mol Pharm 7:565-75. 2010..Importantly, our studies indicate that PLC-NPs may be a promising delivery system to enhance the oral bioavailability of highly water-soluble drugs...
- Hydroxyalkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier functionPeter V Usatyuk
Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA
Microvasc Res 83:45-55. 2012..Similarly, oxidized phospholipids (Ox-PLs) generated by lipid peroxidation of phospholipids with polyunsaturated fatty acids have been ..
- Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDLSara Elsøe
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
Atherosclerosis 221:91-7. 2012..Being a lipocalin, apoM contains a binding pocket for small lipophilic molecules. Here, we report that apoM likely serves as an antioxidant in HDL by binding oxidized phospholipids, thus enhancing the antioxidant potential of HDL.
- Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensationPeter Friedman
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093 0601, USA
J Biol Chem 277:7010-20. 2002..The process yields a variety of bioactive products, including aldehyde-containing phospholipids, which can cross-react with primary amines (i.e...
- Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosisThomas Pomorski
Department of Membrane Enzymology, Center for Biomembranes and Lipid Enzymology, Utrecht University, The Netherlands
Mol Biol Cell 14:1240-54. 2003..Moreover, it appears that Dnf1p, Dnf2p and Drs2p each help regulate the transbilayer lipid arrangement in the plasma membrane, and that this regulation is critical for budding endocytic vesicles...
- Phospholipid scramblase: an updateEdouard M Bevers
Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
FEBS Lett 584:2724-30. 2010..Observations on cells from patients with Scott syndrome, a rare hereditary bleeding disorder resulting from impaired lipid scrambling, have shown that there are multiple activation pathways that converge on scramblase activity...
- Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipidsJing Cao
University of Minnesota, Minneapolis, MN 55455, USA
Clin Chem 52:2265-72. 2006..To study the effects of fatty acid supplementation, we investigated the rate of incorporation and clearance of these fatty acids in erythrocyte membranes and plasma after intake of supplements...
- The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growthHelena Santos-Rosa
WellcomeTrust Cancer Research UK Gurdon Institute, Cambridge, UK
EMBO J 24:1931-41. 2005..Our data suggest that Smp2 is a critical factor in coordinating phospholipid biosynthesis at the nuclear/ER membrane with nuclear growth during the cell cycle...
- FADS gene polymorphisms in Koreans: association with ω6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery diseaseJung Hyun Kwak
Interdisciplinary Course of Science for Aging, Yonsei University, Seoul, South Korea
Atherosclerosis 214:94-100. 2011We investigated the association of polymorphisms in FADS genes with polyunsaturated fatty acids (PUFAs) in serum phospholipids, lipid peroxides, and coronary artery disease (CAD) in Koreans.
- Separation of liquid phases in giant vesicles of ternary mixtures of phospholipids and cholesterolSarah L Veatch
Departments of Chemistry and Physics, University of Washington, Seattle, Washington 98195 1700, USA
Biophys J 85:3074-83. 2003..To date, we have not observed macroscopic separation of liquid phases in only binary lipid mixtures...
- Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivoA D Watson
Department of Medicine, Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095 1679, USA
J Biol Chem 272:13597-607. 1997..Previous studies from our laboratory suggest that oxidized arachidonic acid-containing phospholipids present in mildly oxidized low density lipoproteins (MM-LDL) can activate endothelial cells to bind monocytes...
- Electrospray mass spectrometry of phospholipidsMelissa Pulfer
Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
Mass Spectrom Rev 22:332-64. 2003b>Phospholipids play a central role in the biochemistry of all living cells. These molecules constitute the lipid bilayer defining the outer confines of a cell, but also serve as the structural entities which confine subcellular components...
- Molecular basis for membrane phospholipid diversity: why are there so many lipids?W Dowhan
Department of Biochemistry and Molecular Biology, University of Texas Houston, Medical School 77225, USA
Annu Rev Biochem 66:199-232. 1997b>Phospholipids play multiple roles in cells by establishing the permeability barrier for cells and cell organelles, by providing the matrix for the assembly and function of a wide variety of catalytic processes, by acting as donors in the ..
- Physiological effects of oxidized phospholipids and their cellular signaling mechanisms in inflammationFiona H Greig
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK
Free Radic Biol Med 52:266-80. 2012Oxidized phospholipids, such as the products of the oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by nonenzymatic radical attack, are known to be formed in a number of inflammatory diseases...
- Half-lives of docosahexaenoic acid in rat brain phospholipids are prolonged by 15 weeks of nutritional deprivation of n-3 polyunsaturated fatty acidsJames C DeMar
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892 1582, USA
J Neurochem 91:1125-37. 2004..Mechanisms must exist in the adult rat brain to minimize DHA metabolic loss, and to do so even more effectively in the face of reduced n-3 PUFA availability for only 15 weeks...
- A comparison of the molecular species compositions of mammalian lung surfactant phospholipidsA D Postle
Allergy and Inflammation Sciences and Biochemistry, University of Southampton, Southhampton, UK
Comp Biochem Physiol A Mol Integr Physiol 129:65-73. 2001..is essential for pulmonary surfactant function, roles for other individual molecular species of surfactant phospholipids have not been established...
- Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairmentMariangela Rondanelli
Department of Applied Health Sciences, Section of Human Nutrition and Dietetics, Azienda di Servizi alla Persona ASP, University of Pavia, Pavia, Italy
Nutr Neurosci 15:46-54. 2012..were randomly assigned to supplement their diet with either an oily emulsion of docosahexaenoic acid (DHA)-phospholipids containing melatonin and tryptophan (11 subjects) or a placebo (14-matched subjects) for 12 weeks...
- A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesionsEugene A Podrez
Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 277:38517-23. 2002..Collectively, our data suggest that formation of this novel family of oxidized phospholipids participates in CD36-mediated recognition of oxidized lipoproteins and foam cell formation in vivo.
- Afadin controls p120-catenin-ZO-1 interactions leading to endothelial barrier enhancement by oxidized phospholipidsAnna A Birukova
Lung Injury Center, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
J Cell Physiol 227:1883-90. 2012..These results demonstrate for the first time a critical role of afadin in the regulation of vascular barrier function in vitro and in vivo via coordination of adherens junction-tight junction interactions...
- Complement activation by phospholipids: the interplay of factor H and C1qLee Aun Tan
MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX13QU, UK
Protein Cell 1:1033-49. 2010..A factor H homologue, β2-glycoprotein-1, also strongly inhibits C1q binding to cardiolipin. Recombinant globular domains of C1q A, B and C chains bound aPL similarly to native C1q, confirming that C1q binds aPL via its globular heads...
- Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipidsPeter X Shaw
Molecular Medicine Research Center and Department of Ophthalmology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Proc Natl Acad Sci U S A 109:13757-62. 2012..A large amount of oxidized phospholipids (oxPLs) are generated in the eye because of sunlight exposure and high oxygen content...
- Regulation of phospholipid synthesis in the yeast Saccharomyces cerevisiaeGeorge M Carman
Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, New Jersey 08901, USA
Annu Rev Biochem 80:859-83. 2011The yeast Saccharomyces cerevisiae, with its full complement of organelles, synthesizes membrane phospholipids by pathways that are generally common to those found in higher eukaryotes...
- Effect of dietary docosahexaenoic acid connecting phospholipids on the lipid peroxidation of the brain in miceSeiichi Hiratsuka
Shizuoka Prefectural Research Institute of Fishery, Yaizu, Shizuoka, Japan
J Nutr Sci Vitaminol (Tokyo) 54:501-6. 2008..Each group of female Balb/c mice was fed a diet containing DHA-connecting phospholipids (DHA-PL) or DHA-connecting triacylglycerols (DHA-TG) for 5 wk. Safflower oil was fed as the control...
- Nonneutralizing HIV-1 gp41 envelope cluster II human monoclonal antibodies show polyreactivity for binding to phospholipids and protein autoantigensS Moses Dennison
Duke Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
J Virol 85:1340-7. 2011..These results demonstrate that lipid-reactive gp41 cluster II antibodies are nonneutralizing due to their inability to bind to the relevant neutralizing epitopes on gp41...
- Cholesterol interactions with phospholipids in membranesHenna Ohvo-Rekilä
Department of Biochemistry and Pharmacy, Abo Akademi University, PO Box 66, FIN 20521, Turku, Finland
Prog Lipid Res 41:66-97. 2002..In a given cell type, membrane phospholipids may amount to more than a thousand molecular species...
- Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acidAllison M Hodge
Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
Am J Clin Nutr 86:189-97. 2007..Dietary fatty acids may be associated with diabetes but are difficult to measure accurately...
- Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureusNagendra N Mishra
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles Medical Center, 1124 West Carson St, Torrance, California 90502, USA
Antimicrob Agents Chemother 53:2312-8. 2009....
- Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stressTracie A Seimon
Department of Medicine, Columbia University, New York, NY 10032, USA
Cell Metab 12:467-82. 2010..We show here that oxidized phospholipids, oxidized LDL, saturated fatty acids (SFAs), and lipoprotein(a) trigger apoptosis in ER-stressed macrophages ..
- Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older menDinka Rees
The Rowett Research Institute, Aberdeen, United Kingdom
Am J Clin Nutr 83:331-42. 2006..Increasing intakes of long-chain n-3 polyunsaturated fatty acids (PUFAs) can decrease markers of immunity. However, dose- and age-related responses have not been identified...
- Tumour phospholipid metabolismF Podo
Laboratory of Cell Biology, Istituto Superiore di Sanita, Rome
NMR Biomed 12:413-39. 1999....
- Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteinsS Horkko
Department of Medicine, University of California, San Diego, La Jolla, California 92093 0682
J Clin Invest 103:117-28. 1999..Those EO- autoantibodies that bound to oxidized phospholipids (e.g...
- Unraveling the mysteries of phospholipid scramblingP J Sims
Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
Thromb Haemost 86:266-75. 2001..Evidence that PLSCR1 may serve functions other than its proposed activity as PL scramblase is also presented...
- Dietary phospholipids, hepatic lipid metabolism and cardiovascular diseaseJeffrey S Cohn
Nutrition and Metabolism Group, Heart Research Institute, Sydney, Australia
Curr Opin Lipidol 19:257-62. 2008An increasing number of studies in experimental animals suggest that dietary phospholipids might be of benefit in the treatment of fatty liver disease...
- An unconventional diacylglycerol kinase that regulates phospholipid synthesis and nuclear membrane growthGil Soo Han
Department of Food Science and the Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
J Biol Chem 283:20433-42. 2008..Mutations that decrease phosphatidate levels decrease nuclear membrane growth in pah1Delta cells. We propose that phosphatidate metabolism is a critical factor determining nuclear structure by regulating nuclear membrane biogenesis...
- Progressive ordering with decreasing temperature of the phospholipids of influenza virusIvan V Polozov
Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, 10D14, 10 Center Drive MSC 1855, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Chem Biol 4:248-55. 2008..Viral fusion appears to be uncorrelated to ordered lipid content. Lipid ordering may contribute to viral stability at lower temperatures, which has recently been found to be critical for airborne transmission...
- Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrityJ W Fluhr
Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, USA
J Invest Dermatol 117:44-51. 2001..We assessed here whether the free fatty acid pool, which is derived from phospholipase-mediated hydrolysis of phospholipids during cornification, contributes to stratum corneum acidification and function...
- Phosphate-deficient oat replaces a major portion of the plasma membrane phospholipids with the galactolipid digalactosyldiacylglycerolMats X Andersson
Goteborg University, Department of Plant Physiology, P O Box 461, Sweden
FEBS Lett 537:128-32. 2003The plasma membranes of oat normally resemble those of other eukaryotes in containing mainly phospholipids and sterols...
- Fatty acid composition of adipose tissue and serum lipids are valid biological markers of dairy fat intake in menA Wolk
Department of Medical Epidemiology, Karolinska Institutet, Box 281, SE 171 77 Stockholm, Sweden
J Nutr 131:828-33. 2001..and heptadecanoic (17:0) fatty acids in the adipose tissue triacylglycerols and serum cholesterol esters and phospholipids reflect long-term dairy fat consumption in free-living men...
- Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations--a comparative bioavailability study of fish oil vs. krill oilJan Philipp Schuchardt
Institute of Food Science and Human Nutrition, Leibniz University Hannover, Germany
Lipids Health Dis 10:145. 2011..Superior bioavailability has been suggested for phospholipid (PL) bound omega-3 FA in krill oil, but identical doses of different chemical forms have not been compared...
- Oxidized phospholipids in minimally modified low density lipoprotein induce apoptotic signaling via activation of acid sphingomyelinase in arterial smooth muscle cellsAlexandra Loidl
Department of Biochemistry, Technische Universitat Graz, Petersgasse 12 2, A 8010 Graz, Austria
J Biol Chem 278:32921-8. 2003Oxidized phospholipids, including 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC) and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC), typically present in minimally modified low density lipoprotein, have ..
- Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and NutritionFrancesca L Crowe
Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
Am J Clin Nutr 88:1353-63. 2008..Plausible biological mechanisms underlie possible associations between fatty acids in blood and risk of prostate cancer; epidemiologic evidence for an association, however, is inconsistent...
- Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathwaysTaras Afonyushkin
Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
Arterioscler Thromb Vasc Biol 30:1007-13. 2010..Oxidized phospholipids (OxPLs), known to accumulate in atherosclerotic vessels, were shown to upregulate vascular endothelial growth ..
- n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health StudyRozenn N Lemaitre
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle 98101, USA
Am J Clin Nutr 77:319-25. 2003....
- Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesiclesNele Alder-Baerens
Institute of Biology and Biophysics, Humboldt University Berlin, 10115 Berlin, Germany
Mol Biol Cell 17:1632-42. 2006..Our results indicate that aminophospholipid asymmetry is created when membrane flows through the Golgi and that P4-ATPases are essential for this process...
- Phospholipids and lipid-based formulations in oral drug deliveryGert Fricker
Phospholipid Research Center, Im Neuenheimer Feld 582, 69120, Heidelberg, Germany
Pharm Res 27:1469-86. 2010b>Phospholipids become increasingly important as formulation excipients and as active ingredients per se...
- How do bacteria resist human antimicrobial peptides?Andreas Peschel
Microbial Genetics, University of Tubingen, Auf der Morgenstelle 28, 72076, Tubingen, Germany
Trends Microbiol 10:179-86. 2002..g. teichoic acids, phospholipids and lipid A); expelling CAMPs through energy-dependent pumps; altering membrane fluidity; and cleaving CAMPs ..
- Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipidsDemet Arac
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Nat Struct Mol Biol 13:209-17. 2006..We propose a model wherein synaptotagmin cooperates with the SNAREs in bringing the synaptic vesicle and plasma membranes together and accelerates membrane fusion through the highly positive electrostatic potential of its C(2)B domain...
- Structural basis for the recognition of oxidized phospholipids in oxidized low density lipoproteins by class B scavenger receptors CD36 and SR-BIDetao Gao
Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 285:4447-54. 2010Specific oxidized phospholipids (oxPC(CD36)) accumulate in vivo at sites of oxidative stress and serve as high affinity ligands for scavenger receptors class B (CD36 and SR-BI)...
- Nutritional deprivation of alpha-linolenic acid decreases but does not abolish turnover and availability of unacylated docosahexaenoic acid and docosahexaenoyl-CoA in rat brainM A Contreras
Section on Brain Physiology and Metabolism, National Institute on Aging, Bethesda 20892, USA
J Neurochem 75:2392-400. 2000..Docosapentaenoic acid (22:5 n-6) reciprocally replaced 22:6 n-3 in brain phospholipids. Calculations using operational equations from our model indicated that 22:6 n-3 incorporation from plasma ..
- Health effects of dietary phospholipidsDaniela Küllenberg
Tumor Biology Center, Dept, of Clinical Research, D 79106 Freiburg, Germany
Lipids Health Dis 11:3. 2012Beneficial effects of dietary phospholipids (PLs) have been mentioned since the early 1900's in relation to different illnesses and symptoms, e.g. coronary heart disease, inflammation or cancer...
- Structural requirements of membrane phospholipids for M-type potassium channel activation and bindingVsevolod Telezhkin
Department of Neuroscience, Physiology, and Pharmacology, University College London, London WC1E 6BT, United Kingdom
J Biol Chem 287:10001-12. 2012..2 could bind to a broad range of phosphoinositides and phospholipids. A mutated Kv7...
- The role of peroxidation of mitochondrial membrane phospholipids in pancreatic β -cell failureZhongmin A Ma
Division of Experimental Diabetes and Aging, Department of Geriatrics and Palliative Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Curr Diabetes Rev 8:69-75. 2012..Specifically, ROS oxidize mitochondrial membrane phospholipids such as cardiolipin, which impairs membrane integrity and leads to cytochrome c release and apoptosis...
- A block in endoplasmic reticulum-to-Golgi trafficking inhibits phospholipid synthesis and induces neutral lipid accumulationMaria L Gaspar
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
J Biol Chem 283:25735-51. 2008..We conclude that this metabolic switch provides a degree of protection to cells during secretory stress...
- Supplementation of arachidonic acid-enriched oil increases arachidonic acid contents in plasma phospholipids, but does not increase their metabolites and clinical parameters in Japanese healthy elderly individuals: a randomized controlled studySaki Kakutani
Institute for Health Care Science, Suntory Wellness Ltd, Osaka, Japan
Lipids Health Dis 10:241. 2011..We also examine the levels of ARA metabolites such as prostanoids during intervention...
- Growth inhibition and induction of apoptosis of colon cancer cell lines by applying marine phospholipidZakir Hossain
Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
Nutr Cancer 61:123-30. 2009..DHA or EPA in combination with NaBt significantly increased caspase-3 activity compared to control. DHA and DHA-rich phosphatidylcholine decreased Bcl-2 level in HT-29 and Caco-2 cells...
- Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activationLonghou Fang
Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 285:32343-51. 2010..The levels of oxidized phospholipids, such as 1-palmitoyl-2-oxovaleroyl-sn-glycero-3-phosphocholine, and of various lysophosphatidylcholines were ..
- The regulation of vesicle trafficking by small GTPases and phospholipids during pollen tube growthYan Zhang
Plant Gene Expression Center, United States Department of Agriculture Agricultural Research Service, Albany, CA 94710, USA
Sex Plant Reprod 23:87-93. 2010..this review, we will focus on two classes of factors that orchestrate vesicle trafficking, small GTPases and phospholipids. We discuss the features of small GTPases and phospholipids that make them ideal components to regulate ..
- Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroidsY Majeed
Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
Br J Pharmacol 162:1509-20. 2011..Steroids are known to modulate fear and anxiety states, and we therefore investigated whether TRPC5 exhibited sensitivity to steroids...
- Contrast-enhanced ultrasound (CEUS) for the characterization of focal liver lesions in clinical practice (DEGUM Multicenter Trial): CEUS vs. MRI--a prospective comparison in 269 patientsK Seitz
Department of Internal Medicine, District Hospital Sigmaringen, Sigmaringen, Germany
Ultraschall Med 31:492-9. 2010..One important aspect is the comparison of CEUS with magnetic resonance imaging (MRI)...
- Process optimization, characterization and evaluation in vivo of oxymatrine-phospholipid complexPeng Fei Yue
Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Int J Pharm 387:139-46. 2010..The oxymatrine and phospholipids in the OMT-PLC were combined by non-covalent bond, not forming a new compound...
- NTE1-encoded phosphatidylcholine phospholipase b regulates transcription of phospholipid biosynthetic genesJ Pedro Fernández-Murray
Department of Pediatrics, Atlantic Research Centre, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
J Biol Chem 284:36034-46. 2009....
- Simultaneous transfer of cholesterol, triglycerides, and phospholipids to high-density lipoprotein in aging subjects with or without coronary artery diseaseCarolina H M Azevedo
Lipid Metabolism Laboratory, Heart Institute, Faculdade de Medicina da Universidade de Sao Paulo, Brazil
Clinics (Sao Paulo) 66:1543-8. 2011To verify whether the capacity of high-density lipoprotein (HDL) to simultaneously receive nonesterified cholesterol, triglycerides, cholesteryl esters, and phospholipids changes with aging and the presence of coronary artery disease.
- Remodelling of the Vibrio cholerae membrane by incorporation of exogenous fatty acids from host and aquatic environmentsDavid K Giles
Section of Molecular Genetics and Microbiology The Institute of Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA
Mol Microbiol 79:716-28. 2011..The current study examines the effects of bile on V. cholerae phospholipids. Bile exposure caused significant alterations to the phospholipid profile of V...
- Dietary phospholipids and intestinal cholesterol absorptionJeffrey S Cohn
Nutrition and Metabolism Group, Heart Research Institute, 7 Eliza St Newtown 2042 NSW, Sydney, Australia
Nutrients 2:116-27. 2010Experiments carried out with cultured cells and in experimental animals have consistently shown that phospholipids (PLs) can inhibit intestinal cholesterol absorption...
- Anionic pulmonary surfactant phospholipids inhibit inflammatory responses from alveolar macrophages and U937 cells by binding the lipopolysaccharide-interacting proteins CD14 and MD-2Koji Kuronuma
Department of Medicine, Program in Cell Biology, National Jewish Health, Denver, Colorado 80206, USA
J Biol Chem 284:25488-500. 2009..Surfactant phospholipids are essential in reducing surface tension at the air-liquid interface and preventing alveolar collapse at the ..
- Staphylococcus aureus mutant screen reveals interaction of the human antimicrobial peptide dermcidin with membrane phospholipidsMin Li
Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Antimicrob Agents Chemother 53:4200-10. 2009..decreased binding of dermcidin to the bacterial surface, indicating that dermcidin interacts with membrane phospholipids. The mode of this interaction was direct, as shown by assays of dermcidin binding to phospholipid preparations,..
- Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipidsAmel Bahloul
Département de Neuroscience, Institut Pasteur, Paris, France
Hum Mol Genet 19:3557-65. 2010..We also show that the cadherin-23 cytoplasmic region, harmonin and myosin VIIa interact with phospholipids on synthetic liposomes...
- Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactationLin Xie
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, People s Republic of China
J Nutr 138:2222-8. 2008..Minor allele homozygotes of rs174553(GG), rs99780(TT), and rs174583(TT) had lower ARA but higher LA in plasma phospholipids and erythrocyte EPG and decreased (n-6) and (n-3) fatty acid product:precursor ratios at 16 and 36 wk of ..
- High content of polyunsaturated fatty acids in muscle phospholipids of a fast runner, the European brown hare (Lepus europaeus)T G Valencak
Research Institute of Wildlife Ecology, University of Veterinary Medicine, Savoyenstrasse 1, 1160 Vienna, Austria
J Comp Physiol B 173:695-702. 2003..b>Phospholipids from both skeletal muscles and heart had a high degree of unsaturation with 66.8+/-0.63% and 65.7+/-0...
- Biology of alveolar type II cellsRobert J Mason
Department of Medicine, National Jewish Medical and Research Center, University of Colorado, Denver, CO 80206, USA
Respirology 11:S12-5. 2006..However, the type II cells work in concert with the other cells in the gas exchange regions of the lung to keep the alveoli open and reduce inflammation due to irritants in the air we breathe...
- Dual role of lipopolysaccharide (LPS)-binding protein in neutralization of LPS and enhancement of LPS-induced activation of mononuclear cellsT Gutsmann
Department of Immunochemistry and Biochemical Microbiology, Center for Medicine and Biosciences, Research Center Borstel, D 23845 Borstel, Germany
Infect Immun 69:6942-50. 2001..of LBP and LPS inhibited binding of these complexes to membranes due to different binding of LBP to LPS or phospholipids. This results in a neutralization of LPS and, therefore, to a reduced production of tumor necrosis factor by ..
- Enzymes of triacylglycerol synthesis and their regulationRosalind A Coleman
Departments of Nutrition and Pediatrics, University of North Carolina, Chapel Hill, NC, USA
Prog Lipid Res 43:134-76. 2004....
- Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomicsVitali Matyash
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
J Lipid Res 49:1137-46. 2008..Rigorous testing demonstrated that the MTBE protocol delivers similar or better recoveries of species of most all major lipid classes compared with the "gold-standard" Folch or Bligh and Dyer recipes...
- The lipid whisker model of the structure of oxidized cell membranesMichael E Greenberg
Department of Cell Biology, Cleveland Clinic, Ohio 44195, USA
J Biol Chem 283:2385-96. 2008..is achieved through the recognition of molecular patterns, including structurally distinct oxidized phospholipids, on target cells by macrophage receptors...
- Discovery metabolite profiling of the prolyl peptidasesAlan Saghatelian; Fiscal Year: 2009..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
- Comprehensive biomarker study to capitalize on existing GWAS in 10K South AsiansDanish Saleheen; Fiscal Year: 2010..and lipoproteins (apoA-I, apoA-II, apoB, apoC-III, apoE, lipoprotein(a), lipoprotein subclasses, oxidized phospholipids, authoantibodies to oxLDL, LpPLA2, sPLA2, myeloperoxidase);(2) insulin resistance and adiposity (insulin, C-..
- FASEB SRC on Lysophospholipd Mediators in Health and DiseaseJulie D Saba; Fiscal Year: 2011..lysophosphatidic acid (LPA) are bioactive lipids generated via catabolism of membrane sphingolipids (S1P) and phospholipids (LPA)...
- BONE MATRIX AND BONE RESORPTIONPaul R Odgren; Fiscal Year: 2012..ia ra OCs. Under SA1.2, we will study the ability of the PH domains to bind specific phospholipids and determine by enzyme inhibition assays if plekhm1 activity, like many OC functions, is regulated by PI3-..
- Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responsesWilliam M Nauseef; Fiscal Year: 2013..to the synergy of human PMN and GpIIA-PLA2 against SA What MPO-mediated modifications of SA proteins and phospholipids occur during phagocytosis? What modifications in SA phospholipids and proteins induced by ROS 1 MPO in the ..
- ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAEANTHONY JUSTIN MUSLIN; Fiscal Year: 2010..and iPLA , which liberate free fatty acids, including arachidonic acid, and lysophospholipids from membrane phospholipids. Preliminary data suggests that Akt2 regulates cardiac glucose metabolism and intracellular phospholipase A2 (..
- FASEB SUMMER CONFERENCE ON PHOSPHOLIPASESAlex Brown; Fiscal Year: 2010..These widely expressed enzymes hydrolyze ester and phosphodiester bonds in membrane phospholipids to generate bioactive lipids and lipid-derived products that regulated many and diverse aspects of cell ..
- Role of Membrane Modifications in the Bioactivities of Conjugated Linoleic AcidsPapasani V Subbaiah; Fiscal Year: 2013..We will also investigate the effect of the presence of CLA at the sn-1 position of phospholipids on the properties of the membranes, since our preliminary studies show that unlike LA, the CLA are ..
- Regulation of Hepatic Lipid and Glucose Metabolism by PC-TP/StarD2David E Cohen; Fiscal Year: 2013..Our long-term goal is to understand mechanistic relationships between membrane phospholipids and metabolic regulation, particularly where they present therapeutic opportunities...
- REGULATION OF PHOSPHOLIPID SYNTHESISGeorge M Carman; Fiscal Year: 2013..DAG produced by Pah1p PAP activity is used for the synthesis of triacylglycerol (TAG) and the major membrane phospholipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE)...
- Apoptosis and Trophoblast FusionNEAL STEWART ROTE; Fiscal Year: 2010..several processes, particularly cessation of cellular proliferation, redistribution of plasma membrane phospholipids to form a phosphatidylserine (PS)-rich exofacial surface, expression and insertion of fusion proteins into the ..
- Lysosomal phospholipase A2 in autoimmune diseaseJAMES ALAN SHAYMAN; Fiscal Year: 2013..Understanding the mechanisms whereby impaired degradation of phospholipids result in the autoimmune phenotype may provide new insights into the pathogenesis of lupus and potential new ..
- Molecular physiology of voltage-gated Ca2+ channelsJian Yang; Fiscal Year: 2013..and pathways, including protein kinases and phosphatases, G proteins, calcium and calmodulin, SNAREs, and phospholipids. We have uncovered a new paradigm for VGCC regulation: The pore-forming a1 subunit of neuronal surface L-type ..
- Phospholipid-Mediated Metabolic Control in Liver and Brown Adipose TissueDavid E Cohen; Fiscal Year: 2013..This research proposal addresses the unanswered question of whether membrane phospholipids regulate nutrient homeostasis...
- Phospholipid flip-flop in biogenic membranesAnant K Menon; Fiscal Year: 2013..Lipid flip-flop across the ER is also required for membrane biogenesis: phospholipids that are synthesized on the cytoplasmic face of the ER must be translocated to the opposite face to enable the ..
- Molecular Regulation of Alpha-Synuclein Misfolding and Toxicity in Two Yeast ModeSHUBHIK DEBBURMAN; Fiscal Year: 2009..discovered familial PD mutation E46K in vivo? Does a-synuclein membrane localization in vivo involve specific phospholipids and is membrane interaction required for in vivo toxicity? Does a- synuclein contain domains that confer ..
- Mechanisms of tubular atrophy in renal diseaseJeffrey R Schelling; Fiscal Year: 2012..for PI(4,5)P2 binding to NHE1 will be determined in vitro using fluorescence microscopy techniques in cells, phospholipids overlays and displacement of fluorescently labeled PI(4,5)P2 bound to NHE1 immobilized on Sepharose beads...
- Smooth muscle cell lipid metabolism and serum amyloid ABarbara M Schreiber; Fiscal Year: 2010..We further hypothesize that sPLA2 activity causes hydrolysis of membrane phospholipids, generating fatty acids that activate sphingomyelinase, contributing to endogenous cholesterol trafficking and ..
- Regulation of the anti-phospholipid response in SLEAnne Davidson; Fiscal Year: 2013..by applicant): The goal of this proposal is to determine the mechanisms for loss of B cell tolerance to phospholipids and mechanisms for tissue damage by anti-phospholipid antibodies in NZW/BXSB F1 (W/B) mice that develop both ..
- Nuclear Lipids in SteroidogenesisMarion B Sewer; Fiscal Year: 2013..Our research has identified a key role for bioactive sphingolipids and phospholipids. These molecules control hormone production by controlling the transcription of steroidogenic genes...
- The Role of Glycolipids and CD1 in the Immunology of Leishmania InfectionLaurence U Buxbaum; Fiscal Year: 2012..Leishmania, rabbits and mice develop antibodies to a type of molecule with fat and sugars called glycoinositol phospholipids (GIPLs), but not to proteins (which are the usual targets of antibodies)...
- The role of acyl-CoA binding proteins in selective autophagyTaras Y Nazarko; Fiscal Year: 2013..training is essential to accomplish lipid profiing of ACBP mutants and to study interactions of ACBPs with phospholipids. To increase my knowledge on selective autophagy and LDs, I will continue to attend both autophagy and lipid ..
- Role of the Tail Domain in Vinculin FunctionSharon L Campbell; Fiscal Year: 2010..In addition, several functional roles for acidic phospholipids (PL) have been proposed, including the involvement of acidic PLs in the activation process as well in ..
- ENHANCEMENT OF CORONARY CONSTRICTION BY COMBUSTION-SOURCE AIR TOXICSMatthew J Campen; Fiscal Year: 2012..effects directly on vascular tissue as well as indirectly by oxidatively modifying endogenous circulating phospholipids, thereby altering the native function of those lipids...
- PLCgamma regulates HNE3 activity through direct binding and dynamic complexesNICHOLAS CONSTANTINE ZACHOS; Fiscal Year: 2011..results in the formation of an intermolecular PH domain which regulates NHE3 activity by binding specific phospholipids in lipid raft microdomains of intestinal epithelial cells...
- Alterations in membrane composition and function eith calorie restrictionJon J Ramsey; Fiscal Year: 2011..three specific aims to test this theory: Specific Aim 1;To determine membrane composition (fatty acids, phospholipids and coenzyme Q) of mitochondrial and plasma membranes from liver and skeletal muscle of control and 40% CR ..
- Anti-Phospholipid Multiplex For Pathologic EpitopesPaul O Neilsen; Fiscal Year: 2010..Our system uses pure synthetic phospholipids to create chemically defined homogenous surfaces towards the goal of determining pathogenic epitopes and ..
- MOLECULAR PROPERTIES OF IONIC PERMEABILITY IN NERVEBertil Hille; Fiscal Year: 2013..The focus will be on the phosphatidyl inositide phospholipids as regulators and signals for channel function...
- Problems in Membrane Protein Crystallography: Hetero-Oligomeric Cytochrome b6fWilliam A Cramer; Fiscal Year: 2012..2) Function of phospholipids. The function of intra-protein lipids has been analyzed in only a few multi-subunit membrane proteins...
- Colonic Cytokinetics and Cell Signaling: Dietary EffectsROBERT STEPHEN CHAPKIN; Fiscal Year: 2012..signaling and Ras protein trafficking;(ii) n-3 PUFA supplant arachidonic acid (AA) in colonocyte membrane phospholipids, with EPA in particular being metabolized into a novel 3-series E-prostaglandin (PGE3), a putative ..
- Plasmalogen-derived bioactive lipids in atherosclerosisDavid A Ford; Fiscal Year: 2013..We have discovered that RCS target the vinyl ether bond of the plasmalogen phospholipids resulting in 1-chlorofatty aldehyde (1-ClFALD) production and have shown that 1-ClFALD levels are increased ..
- Activation of PI Specific Phospholipase C EnzymesMARY FEDARKO ROBERTS; Fiscal Year: 2013..PUBLIC HEALTH RELEVANCE: This research will provide new insights into how phospholipids in membranes interact with and modulate the activities of enzymes that transiently bind to the membrane...
- Role of phosphatidylethanolamine in regulating virulence in Candida albicansSARAH ELIZABETH DAVIS; Fiscal Year: 2013..30% mortality rate) in intensive care units This fellowship proposal explores the hypothesis that the phospholipids phosphatidylethanolamine (PE) and phosphatidylserine (PS) affect virulence by affecting signal transduction ..
- Host-associated regulation of P. aeruginosa colonization and virulenceDeborah A Hogan; Fiscal Year: 2013..aeruginosa virulence factor is a secreted phospholipase C, PlcH, which degrades choline- containing phospholipids, such as phosphatidylcholine (PC), that are highly abundant in the lung...
- Glycerolipid synthesis in liverROSALIND ANNE COLEMAN; Fiscal Year: 2013..the rate of TAG synthesis under differing physiological conditions, to adjust the fatty acid composition of phospholipids and TAG, and to regulate nutrient-mediated signaling cascades that involve mTOR, PPAR?, and protein kinase C...
- PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTIONGeorge M Carman; Fiscal Year: 2013..By the nature of its reaction, PAP also controls the cellular content of PA, which is the precursor of phospholipids synthesized via the CDP-DAG pathway...
- Roles of Phospholipase D in AT1 Receptor EndocytosisGuangwei Du; Fiscal Year: 2010..It has been recognized that interaction between proteins and membrane (particularly phospholipids) drives initiation, fission, and fusion of endocytic vesicles...
- Role of LXR and ABCA1 in Abeta Aggregation and ToxicityNICHOLAS FRANCIS FITZ; Fiscal Year: 2012DESCRIPTION (provided by applicant): The Abca1 and apolipoproteins regulate cholesterol and phospholipids efflux, and HDL formation. Abca1 ko mice exhibit decreased cholesterol efflux and poorly-lipidated ApoA-l and ApoE...
- Oxidative Lipidomics in Pediatric Traumatic Brain InjuryHulya Bayir; Fiscal Year: 2012..Our hypothesis is that TBI initiates excessive production of ROS and selective early oxidation of phospholipids with accumulation of oxidized CL triggering release of pro-apoptotic factors from mitochondria...
- A Simple Cellular Model for LipodystrophyJoel M Goodman; Fiscal Year: 2013..Lipid droplets are not just coalesced neutral lipids in the cytoplasm but are surrounded by a monolayer of phospholipids into which are integrated a constellation of specific proteins;they emanate from the endoplasmic reticulum (ER)..
- Regulation of the anti-phospholipid response in SLEAnne Davidson; Fiscal Year: 2009The goal of this proposal is to determine the mechanisms for loss of B cell tolerance to phospholipids and mechanisms for tissue damage by anti-phospholipid antibodies in NZW/BXSB F1 (W/B) mice that develop both proliferative ..
- 12-HETrE regulation of plateletsMICHAEL ALLAN HOLINSTAT; Fiscal Year: 2013..Since DGLA is highly expressed in the phospholipids of the cell membrane and 12-LOX metabolites can be released into circulation in [unreadable]M concentrations, ..
- Inflammation, Atherosclerosis and ApoA-IMary G Sorci-Thomas; Fiscal Year: 2013..changes mainly through its ability to organize and recruit cholesterol and oxygenated forms of cholesterol and phospholipids from immune cells protecting them from dysregulation and apoptosis...
- Functional Genomics and Molecular Imaging of Liver Disease and CancerGORDON SHOJI OKIMOTO; Fiscal Year: 2013..this time whether the changes in choline phospholipid metabolism are due to an in- creased demand for membrane phospholipids or an increase in mitogenic signaling, given that phosphocholine is both a membrane phospholipid and important ..
- Role of a Novel Lysophospholipase in TumorigenesisYing Huang; Fiscal Year: 2012DESCRIPTION (provided by applicant): Phospholipids and lysophospholipids are known to act as lipid mitogens that regulate cell proliferation and survival signaling pathways...
- Lipid Signaling During FertilizationBradley J Stith; Fiscal Year: 2010DESCRIPTION (provided by applicant): There is numerous membrane events associated with fertilization: phospholipids metabolism, membrane fusion during the sperm acrosome reaction, during sperm-egg fusion, during cortical granule ..
- Control of lung permeability by oxidized phospholipidsKonstantin Birukov; Fiscal Year: 2012..Oxidative stress accompanying these pathologies results in increased levels of oxidized phospholipids (OxPL) in the pulmonary circulation...
- Role of Group 1B Phospholipase A2 on Diet-induced Metabolic DiseasesDavid Y Hui; Fiscal Year: 2013..This gene encodes the Group 1B phospholipase A2 protein (PLA2G1B) that hydrolyzes phospholipids to generate free fatty acids and lysophospholipids (lysoPL) in the digestive tract...
- Cancer cell signaling through lipids complexed to proteinsRAYMOND DANIEL BLIND; Fiscal Year: 2013..At the molecular level, these two transcription factors bind phosphoinositides (PIPs), phospholipids that are essential to PI-3 kinase signaling in PTEN-dependent cancers...
- B CELL HYPERACTIVITY IN AUTOIMMUNITYAnn Marshak Rothstein; Fiscal Year: 2010..of a wide range of autoantibodies specific for self antigens such as chromatin, ribonucleoproteins and phospholipids. These antibodies and/or immune complexes containing these antibodies can deposit in blood vessel walls, ..
- Mapping Lipid Oxidation in Traumatic Brain Injury by Mass Spectrometric ImagingValerian E Kagan; Fiscal Year: 2013..We reported that two anionic phospholipids-mitochondrial cardiolipin (CL) and extramitochondrial phosphatidylserine (PS) - are major targets of TBI-..
- Role of PLAB1B in the Development of Hyperlipidemia Associated AtherosclerosisNORRIS ISAAC HOLLIE; Fiscal Year: 2013..A2 group 1B is a digestive enzyme that aids digestion by selectively catalyzing the conversion of phospholipids in the gut lumen to lysophosphatidylcholine (LPC) and fatty acid...
- Antibody immunotherapeutics for biodefense against Lassa virusRobert F Garry; Fiscal Year: 2013..with related Ne and Old World arenaviral proteins and reactivity of LASV huMAbs with human cell membrane phospholipids. In MILESTONE 2 we will generate CHO or NS0 stable cell lines in chemically defined serum free medium and ..
- Targeting the Foam Cell to Prevent AtherosclerosisANTONIO PAUL; Fiscal Year: 2013..LDs consist of a core of neutral lipid stabilized and circumscribed by phospholipids, free CHOL (FC) and proteins...
- Cell Death and Antibody-Mediated Protection from AutoimmunityGREGG JOSHUA SILVERMAN; Fiscal Year: 2010..properties of specific natural antibodies are linked to binding specificities for neo-determinants on oxidized phospholipids that enable the recognition of apoptosis-associated epitopes, and whether such antibody autospecificities ..
- Structure and Function of HAD Phosphatase Partners Dullard and LipinDebra Dunaway-Mariano; Fiscal Year: 2013DESCRIPTION (provided by applicant): Diacylglycerides, the precursors to triacylglycerides and phospholipids, are derived from membrane phosphatidic acids (PA) through the phosphate ester hydrolysis reaction catalyzed by three isoforms ..
- GENETIC ANALYSIS OF PROTEIN EXPORTThomas J Silhavy; Fiscal Year: 2013..All of the components of the OM, phospholipids (PL), lipopolysaccharide (LPS), lipoproteins (LP), and [unreadable]-barrel proteins (OMPs), are synthesized in ..
- Molecular Pathways Regulating Airway Goblet Cell Mucin SecretionBurton F Dickey; Fiscal Year: 2013..priming proteins that bind DAG and Ca2+, and the SNARE-triggering Synaptotagmin (Syt) proteins that bind phospholipids and Ca2+...
- Anionic Surfactant Lipid Regulation of Inflammation and Infection in the LungDennis R Voelker; Fiscal Year: 2013..We have recently discovered that two of the minor components of pulmonary surfactant, the anionic phospholipids phosphatidylglycerol (PtdGro) and phosphatidylinositol (PtdIns), are also potent regulators of inflammation ..
- Citicoline Treatment of Methamphetamine DependencePERRY FRANKLIN RENSHAW; Fiscal Year: 2010..The mechanism includes activation of the biosynthesis of structural phospholipids in neuronal membranes and an increase of norepinephrine and dopamine levels in the central nervous system...
- Protein, Enzyme, and Biological Water Dynamics: 2D Vibrational Echo SpectroscopyMichael D Fayer; Fiscal Year: 2011..The dynamics and interactions of water at the surfaces of model phospholipids membranes will be studied using 2D-IR spectroscopy...
- Plasma Gelsolin and Host Defense After Lung InjuryLester Kobzik; Fiscal Year: 2013..We will also investigate whether plasma gelsolin functions by delivering signaling phospholipids present in lung fluids and known to activate NOS3, e.g...
- MOLECULAR MECHANISMS OF OXIDATION OF LDLSampath Parthasarathy; Fiscal Year: 1999..The applicant proposes to study mechanisms by which apolipoprotein B (apoB) and amino phospholipids (phosphatidylethanolamine) of LDL play a role in the propagation of lipid peroxidation and in the generation ..
- LIPID MODULATION OF RHODOPSIN SIGNALING IN MEMBRANESMichael F Brown; Fiscal Year: 2010..The retinal rod disk membranes are extraordinarily abundant in phospholipids containing highly polyunsaturated fatty acids, including docosahexaenoic acid (DHA;22:6-omega-3) and ..
- ANTI-AIDS NUCLEOSIDE CONJUGATES OF ETHER PHOSPHOLIPIDSCHUNG HONG; Fiscal Year: 1992A series of anti-HIV nucleoside conjugates of ether and thioether phospholipids will be synthesized in an attempt to improve therapeutic indices of the parent drugs...
- GLYCEROLIPIDS AND PROSTAGLANDIN BIOSYNTHESISATA ABDEL LATIF; Fiscal Year: 2001..into IP3 and DAG, the two second messengers, and the concomitant liberation from membrane phospholipids of AA for eicosanoid biosynthesis...
- DIVALENT CATIONS AND CARDIAC LIPID METABOLISMMARGARET WEIS; Fiscal Year: 1990..concentrations are important in regulating the arachidonic acid content and overall fatty acid composition of phospholipids. In the isolated rabbit heart, the synthesis of prostaglandins from exogenous arachidonic acid is ..
- MECHANISM AND ROLE OF MICROSOMAL ETHANOL OXIDATIONCharles Lieber; Fiscal Year: 2001..Specifically, we will evaluate in vitro how the fatty acid composition of the phospholipids may affect 2E1 catalytic activity...
- AUTOIMMUNE MECHANISMS OF THROMBOSISRobert Roubey; Fiscal Year: 2004..an abnormal immune response leads to the production of autoantibodies with an apparent specificity for anionic phospholipids. These autoantibodies are strongly associated with both arterial and venous thrombosis...
- Irradiation Damage and Protection of Pulmonary Endothelium Oxidative LipidomicsValerian E Kagan; Fiscal Year: 2010..We have recently shown that upon interaction with anionic phospholipids, particularly mitochondria-specific cardiolipin (CL), cytochrome c (cyt c) loses its tertiary structure and ..
- LIPID METABOLISM IN STIMULATED HUMAN PLATELETSM Broekman; Fiscal Year: 1991..I plan to investigate: 1) pathways of synthesis of arachidonate containing phospholipids (with emphasis on individual molecular species of the phospholipids involved) in resting and stimulated ..
- Role of Subunit III in Cytochrome Oxidase FunctionJonathan Hosler; Fiscal Year: 2007..High resolution structures of cytochrome oxidase show that subunit III is associated with tightly bound phospholipids. Mutagenesis and phospholipase treatment of cytochrome c oxidase of the bacterium Rhodobacter sphaeroides, ..
- RETINAL MICROVESSELS BASIS FOR INJURY IN DIABETESGary Goldstein; Fiscal Year: 1990..We believe that intracellular sorbitol may interfere with receptor mediated turnover of inositol phospholipids and subsequent activation of protein kinase C and this may, in part, underlie the microangiopathy...