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| membrane lipidsSummarySummary: Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation. Top Publications
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Publications
Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signallingTobias Zech
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
EMBO J 28:466-76. 2009..These results correlate the accumulation of specific molecular lipid species with the specific plasma membrane condensation at sites of TCR activation and with early TCR activation responses...
Profiling membrane lipids in plant stress responses. Role of phospholipase D alpha in freezing-induced lipid changes in ArabidopsisRuth Welti
Division of Biology, Ackert Hall, Kansas State University, Manhattan, Kansas 66506, USA
J Biol Chem 277:31994-2002. 2002....- Docosahexaenoic acid: membrane properties of a unique fatty acidWilliam Stillwell
Department of Biology, Indiana University Purdue University Indianapolis, 723 W Michigan Street, Indianapolis, IN 46202 5132, USA
Chem Phys Lipids 126:1-27. 2003..It is concluded that DHA's interaction with other membrane lipids, particularly cholesterol, may play a prominent role in modulating the local structure and function of cell .. 
Mechanism and regulation of the violaxanthin cycle: the role of antenna proteins and membrane lipidsPeter Jahns
Plant Biochemistry, Heinrich Heine University Dusseldorf, Universitatsstr 1, D 40225 Dusseldorf, Germany
Biochim Biophys Acta 1787:3-14. 2009..The consequences of these findings for the mechanism and regulation of xanthophyll conversion in the thylakoid membrane will be discussed...- Membrane curvature and mechanisms of dynamic cell membrane remodellingHarvey T McMahon
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Nature 438:590-6. 2005..This is seen during vesicle budding and in the formation of microenvironments. On a larger scale, membrane curvature is a prime player in growth, division and movement... - Mutants of Arabidopsis reveal many roles for membrane lipidsJames G Wallis
Institute of Biological Chemistry, Washington State University, Pullman, WA 99164-6340, USA
Prog Lipid Res 41:254-78. 2002..Just as importantly, the availability of a series of plant lines with specific changes in membrane lipids have provided a new resource to study the structural and adaptive roles of lipids... - Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypesK Matsuzaki
Graduate School of Biostudies, Kyoto University, Yoshida Shimoadachi Cho 46 29, Sakyo ku, Kyoto, Japan
Biochim Biophys Acta 1462:1-10. 1999.... - Emerging roles for lipids in shaping membrane-protein functionRob Phillips
Department of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA
Nature 459:379-85. 2009..The free-energy cost of such perturbations can be estimated quantitatively, and measurements of channel gating in model systems of membrane proteins with their lipid partners are now confirming predictions of simple models... - The Arabidopsis DSO/ABCG11 transporter affects cutin metabolism in reproductive organs and suberin in rootsDavid Panikashvili
Department of Plant Sciences, Weizmann Institute of Science, PO Box 26, Rehovot 76100, Israel
Mol Plant 3:563-75. 2010..Taken together, this study provides new insights into cutin and suberin metabolism and their role in reproductive organs and roots development... - Lysosomal degradation of membrane lipidsThomas Kolter
LiMES Life and Medical Sciences Institute, Membrane Biology and Lipid Biochemistry Unit, c o Kekulé Institut für Organische Chemie und Biochemie, University of Bonn, Bonn, Germany
FEBS Lett 584:1700-12. 2010.... - Toroidal pores formed by antimicrobial peptides show significant disorderDurba Sengupta
Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
Biochim Biophys Acta 1778:2308-17. 2008..It was also found that in the absence of counter ions pores not only form more rapidly but lead to membrane rupture. The rupture process occurs via a novel recursive poration pathway, which we coin the Droste mechanism... - Membrane-associated stress proteins: more than simply chaperonesIbolya Horvath
Institute of Biochemistry, Biological Research Centre, Szeged, Temesvari krt 62, Hungary
Biochim Biophys Acta 1778:1653-64. 2008..The possession of such information is critical if we are to target the membrane association principles of HSPs for successful drug development in most various diseases... - The role of membrane lipids in regulation of integrin functionsG Pande
Centre for Cellular and Molecular Biology, Uppal Road, 500 007, Hyderabad, India
Curr Opin Cell Biol 12:569-74. 2000..A better knowledge of integrin functions, especially in the lipid milieu of plasma membranes, is necessary for the understanding of the phenomena that are regulated by integrins... - De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturationEvelien Rysman
Laboratory for Experimental Medicine and Endocrinology, K U Leuven, Leuven, Belgium
Cancer Res 70:8117-26. 2010..These findings provide important new insights into the role of de novo lipogenesis in cancer cells, and they provide a rationale for the use of lipogenesis inhibitors as antineoplastic agents and as chemotherapeutic sensitizers... - Membrane organization and lipid raftsKai Simons
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
Cold Spring Harb Perspect Biol 3:a004697. 2011..Here we will review the emerging principles of membrane architecture with special emphasis on lipid organization and domain formation... - Membrane lipids in invadopodia and podosomes: key structures for cancer invasion and metastasisHideki Yamaguchi
Growth Factor Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
Oncotarget 1:320-8. 2010..This review will summarize recent progress on the molecular mechanisms of invadopodia/podosome formation, with strong emphasis on the roles of lipid rafts and phosphoinositides... - Lipid rafts as functional heterogeneity in cell membranesDaniel Lingwood
Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
Biochem Soc Trans 37:955-60. 2009..Evaluation of this property suggests that functional raft heterogeneity arises through principles of lipid-driven phase segregation coupled to additional chemical specificities, probably involving proteins... - Amino acid-containing membrane lipids in bacteriaOtto Geiger
Centro de Ciencias Genomicas, Universidad Nacional Autonoma de Mexico, Apdo Postal 565 A, Cuernavaca, Morelos CP62210, Mexico
Prog Lipid Res 49:46-60. 2010In the bacterial model organism Escherichia coli only the three major membrane lipids phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin occur, all of which belong to the glycerophospholipids... - Phospholipid synthesis and lipid composition of subcellular membranes in the unicellular eukaryote Saccharomyces cerevisiaeE Zinser
Institut fur Biochemie und Lebensmittelchemie, Technische Universitat Graz, Austria
J Bacteriol 173:2026-34. 1991..The rigidity of the plasma membrane and of secretory vesicles, determined by measuring fluorescence anisotropy by using trimethylammonium diphenylhexatriene as a probe, can be attributed to the high content of ergosterol... - Membrane proteins, lipids and detergents: not just a soap operaAnnela M Seddon
Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
Biochim Biophys Acta 1666:105-17. 2004..We highlight some of the lessons learnt from studies of membrane protein folding in vitro and give an overview of the role that lipids can play in stabilizing the proteins... - Functions of lipid rafts in biological membranesD A Brown
Department of Biochemistry and Cell Biology, State University of New York at Stony Brook 11794 5215, USA
Annu Rev Cell Dev Biol 14:111-36. 1998..Rafts may also function in sorting and trafficking through the secretory and endocytic pathways... - Membrane potential governs lateral segregation of plasma membrane proteins and lipids in yeastGuido Grossmann
University of Regensburg, Cell Biology and Plant Physiology, Regensburg, Germany
EMBO J 26:1-8. 2007..In accordance with these observations, depolarized membranes also considerably change their physical properties (detergent sensitivity)... - Membrane binding domainsJames H Hurley
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
Biochim Biophys Acta 1761:805-11. 2006..These domains use a combination of specific headgroup interactions, hydrophobic membrane penetration, electrostatic surface interactions, and shape complementarity to bind to specific subcellular membranes... - Dynamic, yet structured: The cell membrane three decades after the Singer-Nicolson modelG Vereb
Department of Biophysics and Cell Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, H-4012, Debrecen, Hungary
Proc Natl Acad Sci U S A 100:8053-8. 2003.... - Cytochrome P450 family member CYP704B2 catalyzes the {omega}-hydroxylation of fatty acids and is required for anther cutin biosynthesis and pollen exine formation in riceHui Li
School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200240, China
Plant Cell 22:173-90. 2010.... - The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assemblyAnna Shavinskaya
Department of Molecular Virology, University of Heidelberg, 69120 Heidelberg, Germany
J Biol Chem 282:37158-69. 2007..Taken together, our results demonstrate that the binding strength of the D2 domain of core for LDs is crucial for determining the efficiency of virus assembly... - Lipid traffic: floppy drives and a superhighwayJoost C M Holthuis
Department of Membrane Enzymology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
Nat Rev Mol Cell Biol 6:209-20. 2005Understanding how membrane lipids achieve their non-random distribution in cells is a key challenge in cell biology at present... - Two types of Alzheimer's beta-amyloid (1-40) peptide membrane interactions: aggregation preventing transmembrane anchoring versus accelerated surface fibril formationMarcus Bokvist
Department of Biophysical Chemistry, , 90187 Ume, Sweden
J Mol Biol 335:1039-49. 2004.... - In vitro low-level resistance to azoles in Candida albicans is associated with changes in membrane lipid fluidity and asymmetryAvmeet Kohli
Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
Antimicrob Agents Chemother 46:1046-52. 2002..The results of the present study suggest for the first time that changes in the status of membrane lipid phase and asymmetry could contribute to azole resistance in C. albicans... - Membrane sphingolipid-ergosterol interactions are important determinants of multidrug resistance in Candida albicansKasturi Mukhopadhyay
Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067. Centre for Cellular and Molecular Biology, Hyderabad 500007, India
Antimicrob Agents Chemother 48:1778-87. 2004..albicans cells... - Putative ammonia-oxidizing Crenarchaeota in suboxic waters of the Black Sea: a basin-wide ecological study using 16S ribosomal and functional genes and membrane lipidsMarco J L Coolen
Royal Netherlands Institute for Sea Research, Department of Marine Biogeochemistry and Toxicology, PO Box 59, 1790 AB Den Burg, The Netherlands
Environ Microbiol 9:1001-16. 2007..These results indicate an abundance of putative nitrifying Archaea at very low oxygen levels within the Black Sea and might form an important source of nitrite for the anammox reaction... - Biophysical properties of lipids and dynamic membranesP A Janmey
Institute for Medicine and Engineering, Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Trends Cell Biol 16:538-46. 2006..Here, we highlight some recent reports that the physical properties of the membrane can help control the function of transmembrane proteins and the motor-dependent elongation of internal organelles, such as the endoplasmic reticulum... - Membrane lipids of symbiotic algae are diagnostic of sensitivity to thermal bleaching in coralsDan Tchernov
Environmental Biophysics and Molecular Ecology Program, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, 71 Dudley Road, New Brunswick, NJ 08901, USA
Proc Natl Acad Sci U S A 101:13531-5. 2004..A clocked molecular phylogenetic analysis suggests that the evolutionary history of symbiotic algae in cnidarians selected for a reduced tolerance to elevated temperatures in the latter portion of the Cenozoic... - Molecular mechanisms of membrane perturbation by antimicrobial peptides and the use of biophysical studies in the design of novel peptide antibioticsK Lohner
Institute of Biophysics and X ray Structure Research, Austrian Academy of Sciences, A 8042 Graz, Austria
Comb Chem High Throughput Screen 8:241-56. 2005..Emphasis is on the role of membrane lipid composition in these processes and in the translocation of antimicrobial peptides... - Regulation of the NPC2 protein-mediated cholesterol trafficking by membrane lipidsHichem D Gallala
LIMES, Membrane Biology and Lipid Biochemistry Unit, Kekule Institut fur Organische Chemie und Biochemie, Universitat Bonn, Bonn, Germany
J Neurochem 116:702-7. 2011..degraded, we have to investigate the complex interactions that take place in this compartment between complex membrane lipids, enzymes and lipid binding and transfer proteins involved... - Modulation of membrane curvature by phosphatidic acid and lysophosphatidic acidEdgar E Kooijman
Department of Biochemistry of Membranes, Center for Biomembranes and Lipid Enzymology, Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, The Netherlands
Traffic 4:162-74. 2003..Alternative models for the regulation of membrane fission based on the strong dependence of the molecular shape of (lyso)phosphatidic acid on pH and divalent cations are also discussed... - T lymphocyte costimulation mediated by reorganization of membrane microdomainsA Viola
Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
Science 283:680-2. 1999..These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains... - Arabidopsis AtGPAT1, a member of the membrane-bound glycerol-3-phosphate acyltransferase gene family, is essential for tapetum differentiation and male fertilityZhifu Zheng
Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan S7N OW9, Canada
Plant Cell 15:1872-87. 2003..Deficiency in AtGPAT1 correlates with several fatty acid composition changes in flower tissues and seeds. Unexpectedly, however, a loss of AtGPAT1 causes no significant change in seed oil content... - Membranes: a meeting point for lipids, proteins and therapiesPablo V Escriba
Laboratory of Molecular Cell Biomedicine, Dept of Biology IUNICS, University of the Balearic Islands, Palma de Mallorca, Spain
J Cell Mol Med 12:829-75. 2008..b>Membrane lipids are crucial in the fission and fusion of lipid bilayers and they also act as sensors to control environmental .. - The control of transmembrane helix transverse position in membranes by hydrophilic residuesShyam S Krishnakumar
Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794 5215, USA
J Mol Biol 374:1251-69. 2007..Knowledge of the magnitudes of transverse shifts induced by different hydrophilic residues should be useful for design of mutagenesis studies measuring the effect of transverse TM helix position upon function... - Role of lipids in virus replicationMaier Lorizate
Department of Infectious Diseases, Virology, University Heidelberg, D 69120 Heidelberg, Germany
Cold Spring Harb Perspect Biol 3:a004820. 2011..Here, we review viral interactions with cellular membranes important for virus entry, cytoplasmic genome replication, and virus egress... - Mechanisms of membrane curvature sensingBruno Antonny
Université de Nice Sophia Antipolis and Centre National de la Recheche Scientifique, Institut de Pharmacologie Moleculaire et Cellulaire, 06560 Valbonne, France
Annu Rev Biochem 80:101-23. 2011..Membrane curvature sensors help to organize very diverse reactions, such as lipid transfer between membranes, the tethering of vesicles at the Golgi apparatus, and the assembly-disassembly cycle of protein coats... - The lipidomes of vesicular stomatitis virus, semliki forest virus, and the host plasma membrane analyzed by quantitative shotgun mass spectrometryLucie Kalvodova
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
J Virol 83:7996-8003. 2009.... - Strategies for the cell-free expression of membrane proteinsSina Reckel
Centre for Biomolecular Magnetic Resonance, Institute for Biophysical Chemistry, University of Frankfurt Main, Frankfurt Main, Germany
Methods Mol Biol 607:187-212. 2010..We provide protocols for the cell-free expression of membrane proteins in different modes including their expression as precipitate as well as their direct synthesis into detergent micelles or lipid bilayers... - How curved membranes recruit amphipathic helices and protein anchoring motifsNikos S Hatzakis
Bio Nanotechnology Laboratory, Department of Neuroscience and Pharmacology and Nano Science Center, University of Copenhagen, Copenhagen, Denmark
Nat Chem Biol 5:835-41. 2009..We therefore anticipate that MC will promote the redistribution of proteins that are anchored in membranes through other types of hydrophobic moieties... - Cryptococcus neoformans cryoultramicrotomy and vesicle fractionation reveals an intimate association between membrane lipids and glucuronoxylomannanDebora L Oliveira
Laboratorio de Estudos Integrados em Bioquimica Microbiana, Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941590, Brazil
Fungal Genet Biol 46:956-63. 2009..These results indicate an intimate association of GXM and lipids in both intracellular and extracellular spaces consistent with polysaccharide synthesis and transport in membrane-associated structures... - Cutin deficiency in the tomato fruit cuticle consistently affects resistance to microbial infection and biomechanical properties, but not transpirational water lossTal Isaacson
Department of Plant Biology, Cornell University, Ithaca, NY 14853, USA
Plant J 60:363-77. 2009..The three cd mutations were mapped to different loci, and the cloning of CD2 revealed it to encode a homeodomain protein, which we propose acts as a key regulator of cutin biosynthesis in tomato fruit... - Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusionMisbaudeen Abdul-Hammed
Membrane Biology and Biochemistry Unit, Life and Medical Sciences Institute LIMES, Bonn, Germany
J Lipid Res 51:1747-60. 2010..Note that the effects of the lipids on cholesterol transfer mediated by NPC2 were similar to their effect on membrane fusion induced by NPC2 and saposin-C... - Lipidomics reveals membrane lipid remodelling and release of potential lipid mediators during early stress responses in a murine melanoma cell lineGabor Balogh
Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary
Biochim Biophys Acta 1801:1036-47. 2010.... - Active fragments from pro- and antiapoptotic BCL-2 proteins have distinct membrane behavior reflecting their functional divergenceYannis Guillemin
Institut de Biologie et Chimie des Protéines IBCP, CNRS UMR5086, University of Lyon, Lyon, France
PLoS ONE 5:e9066. 2010..Although the association of these proteins with the outer mitochondrial membrane is crucial for their function, little is known about the characteristics of this interaction... - Invadopodia biogenesis is regulated by caveolin-mediated modulation of membrane cholesterol levelsGiusi Caldieri
Tumor Cell Invasion Laboratory, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Chieti, Italy
J Cell Mol Med 13:1728-40. 2009.... - Roles of lipid polymorphism in intracellular deliveryI M Hafez
Department of Biochemistry and Molecular Biology, University of British Columbia, 2146 Health Sciences Mall, British Columbia V6T 1Z3, Vancouver, Canada
Adv Drug Deliv Rev 47:139-48. 2001.... - A modeling framework describing the enzyme regulation of membrane lipids underlying gradient perception in Dictyostelium cellsJ Krishnan
Department of Electrical and Computer Engineering, Johns Hopkins University, 105 Barton Hall, 3400 N Charles St, Baltimore, MD 21218, USA
J Theor Biol 229:85-99. 2004..An analysis of a basic module underlying this process is also performed... - Interaction of quorum signals with outer membrane lipids: insights into prokaryotic membrane vesicle formationLauren Mashburn-Warren
The University of Texas at Austin, Austin, TX 78712, USA
Mol Microbiol 69:491-502. 2008..Finally, we show that PQS stimulated purified LPS to form liposome-like structures. These studies provide molecular insight into P. aeruginosa MV formation and demonstrate that quorum signals serve important non-signalling functions... - Cuticular lipid composition, surface structure, and gene expression in Arabidopsis stem epidermisMi Chung Suh
Department of Plant Biology, Michigan State University, East Lansing, Michigan 48824, USA
Plant Physiol 139:1649-65. 2005..The 15% transcripts preferentially expressed in the epidermis were enriched in genes encoding proteins predicted to be membrane associated and involved in lipid metabolism. An analysis of the lipid-related subset is presented... - Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticityTracy L Flach
Immunology Research Group, Department of Microbiology and Infectious Diseases, and Snyder Institute, University of Calgary, Calgary, Alberta, Canada
Nat Med 17:479-87. 2011..Here we report that, independent of inflammasome and membrane proteins, alum binds dendritic cell (DC) plasma membrane lipids with substantial force... - Fast molecular tracking maps nanoscale dynamics of plasma membrane lipidsSteffen J Sahl
Department of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
Proc Natl Acad Sci U S A 107:6829-34. 2010..Our experimental approach demonstrates that fast molecular movements can be tracked with minimal invasion, which can reveal new important details of cellular nano-organization... - Analyzing heat capacity profiles of peptide-containing membranes: cluster formation of gramicidin AV P Ivanova
Membrane Biophysics and Thermodynamics Group, Max-Planck-Institute for Biophysical Chemistry, , Germany
Biophys J 84:2427-39. 2003..On the basis of these findings we described the effect of proteins on local fluctuations. It is shown that the elastic properties of the membrane are influenced in the peptide environment... - Molecular dynamics simulations of hydrophilic pores in lipid bilayersHari Leontiadou
Department of Biophysical Chemistry, University of Groningen, Nijenborgh, Groningen, The Netherlands
Biophys J 86:2156-64. 2004..In the simulations the mechanical threshold tension necessary to cause rupture of the membrane on a nanosecond timescale is much higher in the case of the equilibrated bilayers, as compared with membranes containing preexisting pores... - Spin-labeled gramicidin a: channel formation and dissociationBoris G Dzikovski
Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14583-1301, USA
Biophys J 87:3504-17. 2004..4-1 mol %) accessible to the ESR methods employed in the study, since this yields non-interacting dimer channels... - Membrane insertion and bilayer perturbation by antimicrobial peptide CM15Sara Pistolesi
Department of Biophysics and National Biomedical Electron Paramagnetic Resonance Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Biophys J 93:1651-60. 2007..spin labels to assess the effects of CM15 binding and accumulation on the physical properties of membrane lipids. We find that as the concentration of membrane-bound CM15 is increased the N-terminal domain of the peptide .. - N-3 polyunsaturated fatty acids impair lifespan but have no role for metabolismTeresa G Valencak
Research Institute of Wildlife Ecology, University of Veterinary Medicine, Savoyenstrasse 1, A 1160 Vienna, Austria
Aging Cell 6:15-25. 2007..These results contradict the 'membrane pacemaker theory of aging', that is, the concept of a direct link between high amounts of membrane PUFAs, elevated BMR, and thus, impaired longevity... - Molecular mechanism for lipid flip-flopsAndrey A Gurtovenko
Computational Laboratory, Institute of Pharmaceutical Innovation, University of Bradford, Bradford, West Yorkshire, BD7 1DP, United Kingdom
J Phys Chem B 111:13554-9. 2007.... - Membrane curvature stress and antibacterial activity of lactoferricin derivativesDagmar Zweytick
Institute of Biophysics and Nanosystems Research, Austrian Academy of Sciences, Schmiedlstrasse 6, A 8042 Graz, Austria
Biochem Biophys Res Commun 369:395-400. 2008..VS1-24 containing a larger hydrophobic volume at the N-terminus than its less active counterpart VS1-13 seems to increase curvature stress in the bilayer and alter the behaviour of the membrane significantly enhancing disruption... - Magainin 2-induced pore formation in the lipid membranes depends on its concentration in the membrane interfaceYukihiro Tamba
Integrated Bioscience Section, Graduate School of Science and Technology, and Department of Physics, Faculty of Science, Shizuoka University, Shizuoka, 422 8529, Japan
J Phys Chem B 113:4846-52. 2009..These data support our model of two-state transition from the binding state to the pore state of the GUV for magainin 2-induced pore formation... - Lipid ion channelsT Heimburg
Niels Bohr Institute, University of Copenhagen, Denmark
Biophys Chem 150:2-22. 2010..Drugs as anesthetics and neurotransmitters are shown to influence the channel likelihood and their lifetimes in a predictable manner. We also discuss the role of proteins in influencing the likelihood of lipid channel formation... - Viral and developmental cell fusion mechanisms: conservation and divergenceAmir Sapir
Department of Biology, The Technion, Israel Institute of Technology, Haifa 32000, Israel
Dev Cell 14:11-21. 2008..These can serve as guidelines in the search for new fusogens, and may allow the formulation of a cross-species, unified theory to explain divergent and convergent evolutionary principles of membrane fusion... - Membrane lipids, EGF receptors, and intracellular signals colocalize and are polarized in epithelial cells moving directionally in a physiological electric fieldMin Zhao
Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
FASEB J 16:857-9. 2002..that a physiological EF redistributed both EGF (epidermal growth factor) receptors and detergent-insoluble membrane lipids asymmetrically, leading to cathodal polarization and enhanced activation of the MAP kinase, ERK1/2... - Effect of line tension on the lateral organization of lipid membranesAna J García Sáez
Biotechnologisches Zentrum der Techische Universität Dresden, 1307 Dresden, Germany
J Biol Chem 282:33537-44. 2007..Our experiments contribute significantly to our knowledge of the physical-chemical parameters that control membrane organization. Importantly, the general trends observed can be extended to cellular membranes... - Structural features of glycosyltransferases synthesizing major bilayer and nonbilayer-prone membrane lipids in Acholeplasma laidlawii and Streptococcus pneumoniaeMaria Edman
Department of Biochemistry, , Sweden
J Biol Chem 278:8420-8. 2003.... - Role of lysine residues in membrane anchoring of saposin CAnping Liu
Department of Chemistry, University of Cincinnati, P.O. Box 210172, Cincinnati, OH 45221-0172, USA
Arch Biochem Biophys 443:101-12. 2005..The MD simulations and vesicle size measurements of lysine-mutant saposins confirm the importance of the two lysine residues in saposin C4-20 for saposin C-induced fusion of negatively charged phospholipid membranes... - Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidolEve Isabelle Pécheur
IFR128 Biosciences Lyon Gerland, Institut de Biologie et Chimie des Proteines, UMR 5086 CNRS Université Claude Bernard Lyon I, 7 passage du Vercors, 69367 Lyon Cedex 07, France e pecheur ibcp fr
Biochemistry 46:6050-9. 2007..Our results suggest that the affinity of ARB for lipid membranes could account for its anti-HCV actions, together with a differential level of interaction with key motifs in HCV glycoproteins of different genotypes... - Visualizing lipid structure and raft domains in living cells with two-photon microscopyKatharina Gaus
Centre for Vascular Research at the University of New South Wales and Department of Haematology, Prince of Wales Hospital, Sydney NSW 2052, Australia
Proc Natl Acad Sci U S A 100:15554-9. 2003.... - Removal of phospho-head groups of membrane lipids immobilizes voltage sensors of K+ channelsYanping Xu
Department of Physiology, University of Pennsylvania, 3700 Hamilton Walk, Philadelphia, Pennsylvania 19104, USA
Nature 451:826-9. 2008..A key question nevertheless remains: is the phospho-head of membrane lipids necessary for the proper function of the voltage sensor itself? Here we show that a given type of Kv channel .. - Role of docosahexaenoic acid in neuronal plasma membranesJohn A Glomset
Howard Hughes Medical Institute, Department of Medicine, and Regional Primate Research Center, University of Washington, Seattle, WA 98195 7370, USA
Sci STKE 2006:pe6. 2006..The aim of this Perspective is to stimulate further work in this important area by discussing recent evidence related to the role of neuronal plasma membrane phosphoglycerides in cell signaling... - A ClC chloride channel homolog and ornithine-containing membrane lipids of Rhizobium tropici CIAT899 are involved in symbiotic efficiency and acid toleranceKeilor Rojas-Jiménez
FB Biologie der Philipps Universität, FG Zellbiologie und Angewandte Botanik, Marburg, Germany
Mol Plant Microbe Interact 18:1175-85. 2005..a fully developed N2-fixing root nodule symbiosis and of a putative beta-hydroxylase that modifies ornithine-containing membrane lipids of R. tropici CIAT899, which, in turn, are contributing to symbiotic performance and acid tolerance. - Virus-induced alterations of membrane lipids affect the incorporation of PrP Sc into cellsDana Avrahami
Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
J Neurosci Res 86:2753-62. 2008..Importantly, membrane rafts are believed to be the conversion site of PrP(C) to PrP(Sc); therefore, the association of exogenous PrP(Sc) with such membrane microdomains may facilitate prion infection... - The cold but not hard fats in ectotherms: consequences of lipid restructuring on susceptibility of biological membranes to peroxidation, a reviewElizabeth L Crockett
Department of Biological Sciences, Ohio University, Athens, OH 45701, USA
J Comp Physiol B 178:795-809. 2008..At low temperatures, enhanced susceptibility may ensure sufficient lipid peroxidation for cellular processes that require lipid oxidation products... - The influence of membrane lipids in Staphylococcus aureus gamma-hemolysins pore formationC Potrich
FBK CNR Istituto di Biofisica, via alla Cascata 56 C, 38100, Povo Trento, Italy
J Membr Biol 227:13-24. 2009.... - Crenarchaeol dominates the membrane lipids of Candidatus Nitrososphaera gargensis, a thermophilic group I.1b ArchaeonAngela Pitcher
Department of Marine Organic Biogeochemistry, NIOZ Royal Netherlands Institute for Sea Research, Den Burg, The Netherlands
ISME J 4:542-52. 2010Analyses of archaeal membrane lipids are increasingly being included in ecological studies as a comparatively unbiased complement to gene-based microbiological approaches... - Temperature acclimation alters oxidative capacities and composition of membrane lipids without influencing activities of enzymatic antioxidants or susceptibility to lipid peroxidation in fish muscleJ M Grim
Department of Biological Science, Irvine Hall, Ohio University, Athens, OH 45701, USA
J Exp Biol 213:445-52. 2010..The apparent mismatch between oxidative capacity and enzymatic antioxidants following temperature acclimation will be addressed in future studies... - How lipids affect the activities of integral membrane proteinsAnthony G Lee
Division of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
Biochim Biophys Acta 1666:62-87. 2004..Finally, the role of non-annular, or 'co-factor' lipids, tightly bound to membrane proteins, is described... - Bacterial membrane lipids in the action of antimicrobial agentsRichard M Epand
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
J Pept Sci 17:298-305. 2011..These findings emphasize the importance of the lipid composition of bacterial membranes in determining the susceptibility of the organism to the action of certain antimicrobial agents... - Electric field strength of membrane lipids from vertebrate species: membrane lipid composition and Na+-K+-ATPase molecular activityThomas Starke-Peterkovic
School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia
Am J Physiol Regul Integr Comp Physiol 288:R663-70. 2005..e., 236-334 mV for vesicles prepared from the total membrane lipids and 223-256 mV for phospholipids alone... - Interaction of sitamaquine with membrane lipids of Leishmania donovani promastigotesAna Maria Dueñas Romero
Groupe Chimiothérapie Antiparasitaire, UMR 8076 CNRS, Faculte de Pharmacie, Universite Paris Sud XI, rue Jean Baptiste Clement, F 92290 Chatenay Malabry, France
Biochim Biophys Acta 1768:246-52. 2007.... - Envelope lipids regulate the in vitro assembly of the HIV-1 capsidFrancisco N Barrera
Biophys J 94:L8-10. 2008..These results suggest that specific lipids of the viral envelope could have a regulatory role in the maturation of type 1 human immunodeficiency virus... - Quantitative retention of membrane lipids in the freeze-fracture replicaAkikazu Fujita
Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, 466 8550, Japan
Histochem Cell Biol 128:385-9. 2007..These results suggest that probes can bind to lipids captured by carbon more efficiently than those captured by platinum. Nonetheless, evaporation of platinum after carbon is indispensable for proper labeling... - Imaging of membrane lipids in single cells by imprint-imaging time-of-flight secondary ion mass spectrometryPeter Sjovall
Chemistry and Materials Technology, SP Swedish National Testing and Research Institute, P O Box 857, SE 501 15 Borås, Sweden
Anal Chem 75:3429-34. 2003.... - In situ assessment of erythrocyte membrane properties during cold storageWillem F Wolkers
Section of Molecular and Cellular Biology, University of California Davis, 95616, USA
Mol Membr Biol 19:59-65. 2002..transitions were observed after 5 days cold storage (4 degrees C ), which indicated phase separation of the membrane lipids. Using fluorescence microscopy, it was determined that the lipid probe 1,1'-dioctadecyl-3,3,3',3-tetramethyl-.. - Interferon-gamma and tumor necrosis factor-alpha disrupt epithelial barrier function by altering lipid composition in membrane microdomains of tight junctionQiurong Li
Institute of General Surgery, Jinling Hospital, Nanjing, PR China
Clin Immunol 126:67-80. 2008..Understanding the intracellular mechanisms involved could be important in devising future therapeutic strategies to induce retightening of the leaky TJ barrier... - Biochemical characterization and membrane fluidity of membranous vesicles isolated from boar seminal plasmaLidia L Piehl
Cátedra de Física, Facultad de Farmacia y Bioquímica and Laboratorio Nacional de Investigación y Servicios en Radicales Libres en Biología y Medicina, Universidad de Buenos Aires, Junin 956, Planta Baja, 1113 Buenos Aires, Argentina
Anim Reprod Sci 92:401-10. 2006..The characteristics of the porcine MV of the seminal plasma, however, differed from those of boar sperm plasma membranes... - Connexins and their environment: effects of lipids composition on ion channelsMichael Cascio
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, United States
Biochim Biophys Acta 1711:142-53. 2005.... - Transmembrane protein topology mapping by the substituted cysteine accessibility method (SCAM(TM)): application to lipid-specific membrane protein topogenesisMikhail Bogdanov
Department of Biochemistry and Molecular Biology, University of Texas-Houston, Medical School, Houston, TX 77030, USA
Methods 36:148-71. 2005..Employing strains in which lipid composition can be controlled temporally during membrane protein synthesis and assembly provides a means to observe dynamic changes in protein topology as a function of membrane lipid composition... - Stoichiometry of lipid interactions with transmembrane proteins--Deduced from the 3D structuresTibor Pali
Max Planck Institut fur biophysikalische Chemie, Abt Spektroskopie, 37070 Gottingen, Germany
Protein Sci 15:1153-61. 2006..Deviations from the geometrical first shell, in the beta-barrel case, are for the smaller protein with a highly curved barrel... - Phase boundaries and biological membranesGerald W Feigenson
Field of Biophysics, Cornell University, Ithaca, New York 14853, USA
Annu Rev Biophys Biomol Struct 36:63-77. 2007..Furthermore, if the underlying interaction energies between lipids and proteins can be determined, then it might be possible to model the distributions of lipids and proteins in a bilayer membrane, even in complex mixtures... - Assess the nature of cholesterol-lipid interactions through the chemical potential of cholesterol in phosphatidylcholine bilayersMd Rejwan Ali
Department of Physics, Texas Tech University, Lubbock, TX 79409, USA
Proc Natl Acad Sci U S A 104:5372-7. 2007..Those complexes were mainly implicated from studies on lipid monolayer that may not be relevant to the lipid bilayer in cell membranes... - Membrane protein insertion: the biology-physics nexusStephen H White
Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
J Gen Physiol 129:363-9. 2007 - H-aggregation of azobenzene-substituted amphiphiles in vesicular membranesJohanna M Kuiper
Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
Langmuir 20:1152-60. 2004.... - Perturbing effects of carvedilol on a model membrane system: role of lipophilicity and chemical structureStephanie Butler
Department of Chemistry 016-00, Temple University, Philadelphia, PA 19122, USA
Biophys Chem 119:307-15. 2006..This combination of high lipophilicity and specific chemical structure appear required for carvedilol's novel antioxidant activity, and may enhance cardioprotection... - Phase separation of lipid membranes analyzed with high-resolution secondary ion mass spectrometryMary L Kraft
Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Science 313:1948-51. 2006..Quantitative information about the chemical composition within small lipid domains was obtained with the use of isotopic labels to identify each molecular species. Composition variations were detected within some domains... - Differential temperature acclimatization responses in the membrane phospholipids of Posthodiplostomum minimum and its second intermediate host, Lepomis macrochirusD Welsh
Department of Natural Science, Peru State College, Peru, Nebraska 68421, USA
J Parasitol 92:764-9. 2006....
Research Grants
- Mapping for Specialized Domains for FCeRI Signaling & InternalizationBridget S Wilson; Fiscal Year: 2010..In Aim 1, we will develop new monovalent probes for plasma membrane lipids. We will use both transmission and X- ray spectral electron microscopy to map the distributions of tagged ..
- NEURAL REGULATION OF PANCREATIC FUNCTIONKIMBERLY SAUNDERS contact KIRKWOOD; Fiscal Year: 2010..that 4-hydroxynonenal (HNE), an aldehyde generated by the action of reactive oxygen species (ROS) on membrane lipids, is an endogenous agonist of TRPA1 which causes peptide release, neurogenic inflammation and pain...
- NEURAL REGULATION OF PANCREATIC FUNCTIONKIMBERLY SAUNDERS contact KIRKWOOD; Fiscal Year: 2010..that 4-hydroxynonenal (HNE), an aldehyde generated by the action of reactive oxygen species (ROS) on membrane lipids, is an endogenous agonist of TRPA1 which causes peptide release, neurogenic inflammation and pain...
- Unique Isoprenoid Biosynthesis Machinery of the Hyperthermophilic ArchaeaHAROLD MONBOUQUETTE; Fiscal Year: 2007..The archaea necessarily have higher throughput isoprenoid biosynthesis machinery; as their membrane lipids are based solely on branched-chain, saturated hydrocarbons condensed with polyol (usually glycerol)-based ..
- LEUKOTRIENES AND MESSENGERS IN PHOTORECEPTOR RENEWALNicolas Bazan; Fiscal Year: 1993This proposal is the continuation of our studies on second messenger systems derived from membrane lipids involved in retinal pigment epithelium - visual cell interactions during photoreceptor renewal...
- LIPID MODULATION OF RHODOPSIN SIGNALING IN MEMBRANESMichael F Brown; Fiscal Year: 2010..Biophysical methods will characterize the influences of membrane lipids on the Meta I}Meta II transition of rhodopsin...
- LIPID MODULATION OF RHODOPSIN SIGNALING IN MEMBRANESMichael Brown; Fiscal Year: 2009..Biophysical methods will characterize the influences of membrane lipids on the Meta I}Meta II transition of rhodopsin...
- MODULATION OF KERATINOCYTE GROWTH AND SPECIALIZATIONCYNTHIA MARCELO; Fiscal Year: 1993..The aims are first, to determine if marked changes occur in other key membrane lipids of these cells (sterols, sphingolipids)...
- OXIDATIVE CELL INJURY: FIRST-EPISODE PSYCHOTIC PATIENTSSahebarao Mahadik; Fiscal Year: 2002..Effects of oxidative cell injury will be examined in lymphocyte plasma membrane lipids, mitochondrial membranes, cellular proteins, and DNA (both Mitochondrial and nuclear)...
- Prostate MRI and MRS: Correlations with Gene ExpressionSandra Gaston; Fiscal Year: 2007..kinase (the first and probably regulatory enzyme in the pathway for de novo synthesis of choline containing membrane lipids) in tissue-print micro-peels obtained from radical prostatectomy specimens containing Gleason grade 6,7 or 8 ..
- PERMEABILITY OF THE LUNG TO WATER SOLUBLE SOLUTESEVELINE SCHNEEBERGER; Fiscal Year: 1990..The role of membrane lipids in tight junction formation, structure and function will be examined in epithelial cells cultured in vitro ..
- SORTING OF A LIPID-PROTEIN COMPLEX IN EPITHELIAL CELLSDeborah Brown; Fiscal Year: 1993..Plasma membrane proteins and some membrane lipids are sorted in the trans Golgi network in certain cultured epithelial cells, and are packaged into transport ..
- MEMBRANE PATHOLOGY IN RENAL CELL INJURYManjeri Venkatachalam; Fiscal Year: 1993..The major thrust of the effort will be to study how catabolism of membrane lipids relates to membrane damage...
- NMR STUDIES OF CYTOSOLIC METAL IONS AND OXIDATIVE STRESSRaj Gupta; Fiscal Year: 2006..We seek to understand how the regulation of intracellular concentrations of essential metal ions and membrane lipids goes astray in health disorders, especially hypertension and diabetes...
- Vasodilation via selective pharmacological targeting of BK channel beta1 subunitsAlex M Dopico; Fiscal Year: 2010..activate BK via specific docking on the channel or, rather, secondarily to nonspecific perturbation of membrane lipids. We recently found that cholane steroids, such as lithocholate (LC), selectively activate 21-containing BK, ..
- PROTEINS OF NORMAL AND CATARACTOUS LENSESFRANK GIBLIN; Fiscal Year: 2005..in vitro, mass spectrometry and infrared spectroscopy to investigate oxidative effects on lens proteins and membrane lipids, and to identify crystallins that have precipitated in the lens because of in vivo oxidative stress...