membrane lipids

Summary

Summary: Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.

Top Publications

  1. ncbi Functions of lipid rafts in biological membranes
    D A Brown
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook 11794 5215, USA
    Annu Rev Cell Dev Biol 14:111-36. 1998
  2. ncbi Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment
    Stephen B Long
    Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 450:376-82. 2007
  3. pmc Membrane lipids of symbiotic algae are diagnostic of sensitivity to thermal bleaching in corals
    Dan Tchernov
    Environmental Biophysics and Molecular Ecology Program, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, 71 Dudley Road, New Brunswick, NJ 08901, USA
    Proc Natl Acad Sci U S A 101:13531-5. 2004
  4. pmc Emerging roles for lipids in shaping membrane-protein function
    Rob Phillips
    Department of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nature 459:379-85. 2009
  5. doi Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity
    Tracy L Flach
    Immunology Research Group, Department of Microbiology and Infectious Diseases, and Snyder Institute, University of Calgary, Calgary, Alberta, Canada
    Nat Med 17:479-87. 2011
  6. ncbi Profiling membrane lipids in plant stress responses. Role of phospholipase D alpha in freezing-induced lipid changes in Arabidopsis
    Ruth Welti
    Division of Biology, Ackert Hall, Kansas State University, Manhattan, Kansas 66506, USA
    J Biol Chem 277:31994-2002. 2002
  7. pmc Sensing voltage across lipid membranes
    Kenton J Swartz
    Porter Neuroscience Research Center, Molecular Physiology and Biophysics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 456:891-7. 2008
  8. pmc Drug resistance in breast cancer cells: biophysical characterization of and doxorubicin interactions with membrane lipids
    Chiranjeevi Peetla
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, United States
    Mol Pharm 7:2334-48. 2010
  9. pmc Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling
    Tobias Zech
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    EMBO J 28:466-76. 2009
  10. ncbi Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes
    K Matsuzaki
    Graduate School of Biostudies, Kyoto University, Yoshida Shimoadachi Cho 46 29, Sakyo ku, Kyoto, Japan
    Biochim Biophys Acta 1462:1-10. 1999

Research Grants

  1. Mapping for Specialized Domains for FCeRI Signaling & Internalization
    Bridget S Wilson; Fiscal Year: 2010
  2. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS contact KIRKWOOD; Fiscal Year: 2010
  3. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS contact KIRKWOOD; Fiscal Year: 2010
  4. Unique Isoprenoid Biosynthesis Machinery of the Hyperthermophilic Archaea
    HAROLD MONBOUQUETTE; Fiscal Year: 2007
  5. LEUKOTRIENES AND MESSENGERS IN PHOTORECEPTOR RENEWAL
    Nicolas Bazan; Fiscal Year: 1993
  6. LIPID MODULATION OF RHODOPSIN SIGNALING IN MEMBRANES
    Michael F Brown; Fiscal Year: 2010
  7. LIPID MODULATION OF RHODOPSIN SIGNALING IN MEMBRANES
    Michael Brown; Fiscal Year: 2009
  8. MODULATION OF KERATINOCYTE GROWTH AND SPECIALIZATION
    CYNTHIA MARCELO; Fiscal Year: 1993
  9. OXIDATIVE CELL INJURY: FIRST-EPISODE PSYCHOTIC PATIENTS
    Sahebarao Mahadik; Fiscal Year: 2002
  10. Prostate MRI and MRS: Correlations with Gene Expression
    Sandra Gaston; Fiscal Year: 2007

Detail Information

Publications279 found, 100 shown here

  1. ncbi Functions of lipid rafts in biological membranes
    D A Brown
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook 11794 5215, USA
    Annu Rev Cell Dev Biol 14:111-36. 1998
    ..Rafts may also function in sorting and trafficking through the secretory and endocytic pathways...
  2. ncbi Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment
    Stephen B Long
    Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 450:376-82. 2007
    ..The detailed structure, which can be compared directly to a large body of functional data, explains charge stabilization within the membrane and suggests a mechanism for voltage-sensor movements and pore gating...
  3. pmc Membrane lipids of symbiotic algae are diagnostic of sensitivity to thermal bleaching in corals
    Dan Tchernov
    Environmental Biophysics and Molecular Ecology Program, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, 71 Dudley Road, New Brunswick, NJ 08901, USA
    Proc Natl Acad Sci U S A 101:13531-5. 2004
    ..A clocked molecular phylogenetic analysis suggests that the evolutionary history of symbiotic algae in cnidarians selected for a reduced tolerance to elevated temperatures in the latter portion of the Cenozoic...
  4. pmc Emerging roles for lipids in shaping membrane-protein function
    Rob Phillips
    Department of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nature 459:379-85. 2009
    ..The free-energy cost of such perturbations can be estimated quantitatively, and measurements of channel gating in model systems of membrane proteins with their lipid partners are now confirming predictions of simple models...
  5. doi Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity
    Tracy L Flach
    Immunology Research Group, Department of Microbiology and Infectious Diseases, and Snyder Institute, University of Calgary, Calgary, Alberta, Canada
    Nat Med 17:479-87. 2011
    ..Here we report that, independent of inflammasome and membrane proteins, alum binds dendritic cell (DC) plasma membrane lipids with substantial force...
  6. ncbi Profiling membrane lipids in plant stress responses. Role of phospholipase D alpha in freezing-induced lipid changes in Arabidopsis
    Ruth Welti
    Division of Biology, Ackert Hall, Kansas State University, Manhattan, Kansas 66506, USA
    J Biol Chem 277:31994-2002. 2002
    ....
  7. pmc Sensing voltage across lipid membranes
    Kenton J Swartz
    Porter Neuroscience Research Center, Molecular Physiology and Biophysics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 456:891-7. 2008
    ..Although further structures are needed to understand the conformational changes that occur during voltage sensing, the available data help to frame several key concepts that are fundamental to the mechanism of voltage sensing...
  8. pmc Drug resistance in breast cancer cells: biophysical characterization of and doxorubicin interactions with membrane lipids
    Chiranjeevi Peetla
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, United States
    Mol Pharm 7:2334-48. 2010
    ..MCF-7) and -resistant (MCF-7/ADR) breast cancer cells to characterize the biophysical properties of membrane lipids (particularly lipid packing and membrane fluidity) and to understand the role of the interaction of cell ..
  9. pmc Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling
    Tobias Zech
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    EMBO J 28:466-76. 2009
    ..These results correlate the accumulation of specific molecular lipid species with the specific plasma membrane condensation at sites of TCR activation and with early TCR activation responses...
  10. ncbi Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes
    K Matsuzaki
    Graduate School of Biostudies, Kyoto University, Yoshida Shimoadachi Cho 46 29, Sakyo ku, Kyoto, Japan
    Biochim Biophys Acta 1462:1-10. 1999
    ....
  11. ncbi Membrane curvature and mechanisms of dynamic cell membrane remodelling
    Harvey T McMahon
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nature 438:590-6. 2005
    ..This is seen during vesicle budding and in the formation of microenvironments. On a larger scale, membrane curvature is a prime player in growth, division and movement...
  12. pmc Phthiocerol dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids
    Catherine Astarie-Dequeker
    CNRS, Institut de Pharmacologie et de Biologie Structurale IPBS, Toulouse, France
    PLoS Pathog 5:e1000289. 2009
    ..The DIM-induced changes in lipid ordering favour the efficiency of receptor-mediated phagocytosis of Mtb and contribute to the control of phagosomal pH driving bacilli in a protective niche...
  13. ncbi Docosahexaenoic acid: membrane properties of a unique fatty acid
    William Stillwell
    Department of Biology, Indiana University Purdue University Indianapolis, 723 W Michigan Street, Indianapolis, IN 46202 5132, USA
    Chem Phys Lipids 126:1-27. 2003
    ..It is concluded that DHA's interaction with other membrane lipids, particularly cholesterol, may play a prominent role in modulating the local structure and function of cell ..
  14. pmc Effects of membrane lipids on the activity and processivity of purified γ-secretase
    Oliver Holmes
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, United States
    Biochemistry 51:3565-75. 2012
    ....
  15. ncbi Mutants of Arabidopsis reveal many roles for membrane lipids
    James G Wallis
    Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
    Prog Lipid Res 41:254-78. 2002
    ..Just as importantly, the availability of a series of plant lines with specific changes in membrane lipids have provided a new resource to study the structural and adaptive roles of lipids...
  16. pmc Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin
    Jeanne Kwik
    Biology Department, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 100:13964-9. 2003
    ..Consistent with this observation, agents that sequester plasma membrane PI(4,5)P2 mimic the effects of cholesterol depletion on actin organization and on lateral mobility...
  17. doi Mechanism and regulation of the violaxanthin cycle: the role of antenna proteins and membrane lipids
    Peter Jahns
    Plant Biochemistry, Heinrich Heine University Dusseldorf, Universitatsstr 1, D 40225 Dusseldorf, Germany
    Biochim Biophys Acta 1787:3-14. 2009
    ..The consequences of these findings for the mechanism and regulation of xanthophyll conversion in the thylakoid membrane will be discussed...
  18. doi Lysosomal degradation of membrane lipids
    Thomas Kolter
    LiMES Life and Medical Sciences Institute, Membrane Biology and Lipid Biochemistry Unit, c o Kekulé Institut für Organische Chemie und Biochemie, University of Bonn, Bonn, Germany
    FEBS Lett 584:1700-12. 2010
    ....
  19. pmc The lipidomes of vesicular stomatitis virus, semliki forest virus, and the host plasma membrane analyzed by quantitative shotgun mass spectrometry
    Lucie Kalvodova
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    J Virol 83:7996-8003. 2009
    ....
  20. doi Protein modulation of lipids, and vice-versa, in membranes
    Derek Marsh
    Max Planck Institut fur biophysikalische Chemie, Abt Spektroskopie, Gottingen, Germany
    Biochim Biophys Acta 1778:1545-75. 2008
    This review describes: (i) perturbations of the membrane lipids that are induced by integral membrane proteins, and reciprocally, (ii) the effects that the lipids may have on the function of membrane-associated proteins...
  21. pmc Role of lipids in virus replication
    Maier Lorizate
    Department of Infectious Diseases, Virology, University Heidelberg, D 69120 Heidelberg, Germany
    Cold Spring Harb Perspect Biol 3:a004820. 2011
    ..Here, we review viral interactions with cellular membranes important for virus entry, cytoplasmic genome replication, and virus egress...
  22. pmc Cuticular lipid composition, surface structure, and gene expression in Arabidopsis stem epidermis
    Mi Chung Suh
    Department of Plant Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Physiol 139:1649-65. 2005
    ..The 15% transcripts preferentially expressed in the epidermis were enriched in genes encoding proteins predicted to be membrane associated and involved in lipid metabolism. An analysis of the lipid-related subset is presented...
  23. ncbi The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells
    C Gajate
    , , CSIC-Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    Blood 98:3860-3. 2001
    ..This translocation of Fas into membrane rafts may provide a mechanism for amplifying Fas signaling by reorganization of membrane microdomains...
  24. ncbi Elastic curvature constants of lipid monolayers and bilayers
    Derek Marsh
    Max Planck Institut fur biophysikalische Chemie, Dept Spektroskopie, 37070 Gottingen, Germany
    Chem Phys Lipids 144:146-59. 2006
    ..Consideration is given to the relation between the bending moduli of bilayers and the constituent monolayer leaflets. Useful mathematical relations involving the bending moduli and spontaneous curvature are summarized...
  25. doi The Arabidopsis DSO/ABCG11 transporter affects cutin metabolism in reproductive organs and suberin in roots
    David Panikashvili
    Department of Plant Sciences, Weizmann Institute of Science, PO Box 26, Rehovot 76100, Israel
    Mol Plant 3:563-75. 2010
    ..Taken together, this study provides new insights into cutin and suberin metabolism and their role in reproductive organs and roots development...
  26. ncbi The role of membrane lipids in regulation of integrin functions
    G Pande
    Centre for Cellular and Molecular Biology, Uppal Road, 500 007, Hyderabad, India
    Curr Opin Cell Biol 12:569-74. 2000
    ..A better knowledge of integrin functions, especially in the lipid milieu of plasma membranes, is necessary for the understanding of the phenomena that are regulated by integrins...
  27. doi Membrane-associated stress proteins: more than simply chaperones
    Ibolya Horvath
    Institute of Biochemistry, Biological Research Centre, Szeged, Temesvari krt 62, Hungary
    Biochim Biophys Acta 1778:1653-64. 2008
    ..The possession of such information is critical if we are to target the membrane association principles of HSPs for successful drug development in most various diseases...
  28. pmc Membrane organization and lipid rafts
    Kai Simons
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Cold Spring Harb Perspect Biol 3:a004697. 2011
    ..Here we will review the emerging principles of membrane architecture with special emphasis on lipid organization and domain formation...
  29. doi Lipid rafts as functional heterogeneity in cell membranes
    Daniel Lingwood
    Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
    Biochem Soc Trans 37:955-60. 2009
    ..Evaluation of this property suggests that functional raft heterogeneity arises through principles of lipid-driven phase segregation coupled to additional chemical specificities, probably involving proteins...
  30. doi Amino acid-containing membrane lipids in bacteria
    Otto Geiger
    Centro de Ciencias Genomicas, Universidad Nacional Autonoma de Mexico, Apdo Postal 565 A, Cuernavaca, Morelos CP62210, Mexico
    Prog Lipid Res 49:46-60. 2010
    In the bacterial model organism Escherichia coli only the three major membrane lipids phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin occur, all of which belong to the glycerophospholipids...
  31. ncbi Molecular dynamics simulations of stratum corneum lipid models: fatty acids and cholesterol
    M Holtje
    Jülich Research Center, Germany
    Biochim Biophys Acta 1511:156-67. 2001
    ..The simulation results are in good agreement with our experimental data from FTIR analysis and NIR-FT Raman spectroscopy...
  32. doi Lipids on the move: simulations of membrane pores, domains, stalks and curves
    Siewert J Marrink
    Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands
    Biochim Biophys Acta 1788:149-68. 2009
    ....
  33. ncbi Membrane lipid domains distinct from cholesterol/sphingomyelin-rich rafts are involved in the ABCA1-mediated lipid secretory pathway
    A J Mendez
    University of Miami School of Medicine, Diabetes Research Institute, Miami, Florida 33101, USA
    J Biol Chem 276:3158-66. 2001
    ..We conclude that cholesterol and sphingomyelin-rich membrane rafts do not provide lipid for efflux promoted by apolipoproteins through the ABCA1-mediated lipid secretory pathway and that ABCA1 is not associated with these domains...
  34. doi Toroidal pores formed by antimicrobial peptides show significant disorder
    Durba Sengupta
    Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    Biochim Biophys Acta 1778:2308-17. 2008
    ..It was also found that in the absence of counter ions pores not only form more rapidly but lead to membrane rupture. The rupture process occurs via a novel recursive poration pathway, which we coin the Droste mechanism...
  35. doi Invadopodia biogenesis is regulated by caveolin-mediated modulation of membrane cholesterol levels
    Giusi Caldieri
    Tumor Cell Invasion Laboratory, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Chieti, Italy
    J Cell Mol Med 13:1728-40. 2009
    ....
  36. doi Amphipathic helices and membrane curvature
    Guillaume Drin
    Université de Nice Sophia Antipolis and CNRS, Institut de Pharmacologie Moleculaire et Cellulaire, Valbonne, France
    FEBS Lett 584:1840-7. 2010
    ..A more detailed description of the interaction between amphipathic helices and lipids is however needed; notably to explain how new helices contribute to detection of modest changes in curvature or even negative curvature...
  37. ncbi Modulation of membrane curvature by phosphatidic acid and lysophosphatidic acid
    Edgar E Kooijman
    Department of Biochemistry of Membranes, Center for Biomembranes and Lipid Enzymology, Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, The Netherlands
    Traffic 4:162-74. 2003
    ..Alternative models for the regulation of membrane fission based on the strong dependence of the molecular shape of (lyso)phosphatidic acid on pH and divalent cations are also discussed...
  38. doi De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation
    Evelien Rysman
    Laboratory for Experimental Medicine and Endocrinology, K U Leuven, Leuven, Belgium
    Cancer Res 70:8117-26. 2010
    ..These findings provide important new insights into the role of de novo lipogenesis in cancer cells, and they provide a rationale for the use of lipogenesis inhibitors as antineoplastic agents and as chemotherapeutic sensitizers...
  39. pmc Characterization of an exported monoglyceride lipase from Mycobacterium tuberculosis possibly involved in the metabolism of host cell membrane lipids
    Karen Côtes
    Laboratoire d Enzymologie Interfaciale et de Physiologie de la Lipolyse, UPR 9025 CNRS, 31 Chemin Joseph Aiguier, F 13402 Marseille Cedex 20, France
    Biochem J 408:417-27. 2007
    ..tuberculosis. Our results identify Rv0183 as the first exported lipolytic enzyme to be characterized in M. tuberculosis and suggest that Rv0183 may be involved in the degradation of the host cell lipids...
  40. pmc Mining the surface proteome of tomato (Solanum lycopersicum) fruit for proteins associated with cuticle biogenesis
    Trevor H Yeats
    Department of Plant Biology, Cornell University, Ithaca, NY 14853, USA
    J Exp Bot 61:3759-71. 2010
    ..This indicated a complex pattern of cuticle deposition, and models for cuticle biogenesis and restructuring are discussed...
  41. pmc Phospholipid synthesis and lipid composition of subcellular membranes in the unicellular eukaryote Saccharomyces cerevisiae
    E Zinser
    Institut fur Biochemie und Lebensmittelchemie, Technische Universitat Graz, Austria
    J Bacteriol 173:2026-34. 1991
    ..The rigidity of the plasma membrane and of secretory vesicles, determined by measuring fluorescence anisotropy by using trimethylammonium diphenylhexatriene as a probe, can be attributed to the high content of ergosterol...
  42. pmc Membrane binding domains
    James H Hurley
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1761:805-11. 2006
    ..These domains use a combination of specific headgroup interactions, hydrophobic membrane penetration, electrostatic surface interactions, and shape complementarity to bind to specific subcellular membranes...
  43. ncbi Membrane proteins, lipids and detergents: not just a soap opera
    Annela M Seddon
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Biochim Biophys Acta 1666:105-17. 2004
    ..We highlight some of the lessons learnt from studies of membrane protein folding in vitro and give an overview of the role that lipids can play in stabilizing the proteins...
  44. pmc Membrane potential governs lateral segregation of plasma membrane proteins and lipids in yeast
    Guido Grossmann
    University of Regensburg, Cell Biology and Plant Physiology, Regensburg, Germany
    EMBO J 26:1-8. 2007
    ..In accordance with these observations, depolarized membranes also considerably change their physical properties (detergent sensitivity)...
  45. pmc Cytochrome P450 family member CYP704B2 catalyzes the {omega}-hydroxylation of fatty acids and is required for anther cutin biosynthesis and pollen exine formation in rice
    Hui Li
    School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200240, China
    Plant Cell 22:173-90. 2010
    ....
  46. pmc Dynamic, yet structured: The cell membrane three decades after the Singer-Nicolson model
    G Vereb
    Department of Biophysics and Cell Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, H 4012, Debrecen, Hungary
    Proc Natl Acad Sci U S A 100:8053-8. 2003
    ....
  47. ncbi Two types of Alzheimer's beta-amyloid (1-40) peptide membrane interactions: aggregation preventing transmembrane anchoring versus accelerated surface fibril formation
    Marcus Bokvist
    Department of Biophysical Chemistry, Umea University, 90187 Umea, Sweden
    J Mol Biol 335:1039-49. 2004
    ....
  48. ncbi Lipid traffic: floppy drives and a superhighway
    Joost C M Holthuis
    Department of Membrane Enzymology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Nat Rev Mol Cell Biol 6:209-20. 2005
    Understanding how membrane lipids achieve their non-random distribution in cells is a key challenge in cell biology at present...
  49. ncbi Effect of line tension on the lateral organization of lipid membranes
    Ana J García-Sáez
    Biotechnologisches Zentrum der Techische Universität Dresden, 1307 Dresden, Germany
    J Biol Chem 282:33537-44. 2007
    ..Our experiments contribute significantly to our knowledge of the physical-chemical parameters that control membrane organization. Importantly, the general trends observed can be extended to cellular membranes...
  50. pmc T cell receptor ligation induces the formation of dynamically regulated signaling assemblies
    Stephen C Bunnell
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 158:1263-75. 2002
    ....
  51. ncbi The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly
    Anna Shavinskaya
    Department of Molecular Virology, University of Heidelberg, 69120 Heidelberg, Germany
    J Biol Chem 282:37158-69. 2007
    ..Taken together, our results demonstrate that the binding strength of the D2 domain of core for LDs is crucial for determining the efficiency of virus assembly...
  52. ncbi Intact polar membrane lipids in prokaryotes and sediments deciphered by high-performance liquid chromatography/electrospray ionization multistage mass spectrometry--new biomarkers for biogeochemistry and microbial ecology
    Helen F Sturt
    Woods Hole Oceanographic Institution, Department of Geology and Geophysics, Woods Hole, MA 02543, USA
    Rapid Commun Mass Spectrom 18:617-28. 2004
    ..However, when still intact, i.e., as glycerol esters and ethers with attached polar headgroups, membrane lipids are diagnostic for living prokaryotes, which makes them excellent biomarkers for the study of in situ ..
  53. doi Membrane proteins diffuse as dynamic complexes with lipids
    Perttu S Niemelä
    VTT Technical Research Center of Finland, Espoo, Finland
    J Am Chem Soc 132:7574-5. 2010
    ..Our results indicate that, in studies of cell membranes, protein and lipid dynamics have to be considered together...
  54. ncbi Caveolins and cellular cholesterol balance
    E Ikonen
    Department of Biochemistry, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Traffic 1:212-7. 2000
    ..Here we review evidence for caveolin regulation of cholesterol transport and consider how this may relate to signal transduction...
  55. pmc In vitro low-level resistance to azoles in Candida albicans is associated with changes in membrane lipid fluidity and asymmetry
    Avmeet Kohli
    Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Antimicrob Agents Chemother 46:1046-52. 2002
    ..The results of the present study suggest for the first time that changes in the status of membrane lipid phase and asymmetry could contribute to azole resistance in C. albicans...
  56. pmc Membrane sphingolipid-ergosterol interactions are important determinants of multidrug resistance in Candida albicans
    Kasturi Mukhopadhyay
    Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067 Centre for Cellular and Molecular Biology, Hyderabad 500007, India
    Antimicrob Agents Chemother 48:1778-87. 2004
    ..albicans cells...
  57. ncbi Biophysical properties of lipids and dynamic membranes
    P A Janmey
    Institute for Medicine and Engineering, Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Trends Cell Biol 16:538-46. 2006
    ..Here, we highlight some recent reports that the physical properties of the membrane can help control the function of transmembrane proteins and the motor-dependent elongation of internal organelles, such as the endoplasmic reticulum...
  58. ncbi Molecular mechanisms of membrane perturbation by antimicrobial peptides and the use of biophysical studies in the design of novel peptide antibiotics
    K Lohner
    Institute of Biophysics and X ray Structure Research, Austrian Academy of Sciences, A 8042 Graz, Austria
    Comb Chem High Throughput Screen 8:241-56. 2005
    ..Emphasis is on the role of membrane lipid composition in these processes and in the translocation of antimicrobial peptides...
  59. ncbi Effect of aliphatic alcohols on growth and degree of saturation of membrane lipids in Acinetobacter calcoaceticus
    Nadja Kabelitz
    Department of Remediation Research, Centre for Environmental Research UFZ Leipzig Halle, Permoserstr 15, 04318 Leipzig, Germany
    FEMS Microbiol Lett 220:223-7. 2003
    ....
  60. pmc Distribution of membrane lipids of planktonic Crenarchaeota in the Arabian Sea
    Jaap S Sinninghe Damsté
    Department of Marine Biogeochemistry and Toxicology, Royal Netherlands Institute for Sea Research, Den Burg, Texel, The Netherlands
    Appl Environ Microbiol 68:2997-3002. 2002
    Intact core tetraether membrane lipids of marine planktonic Crenarchaeota were quantified in water column-suspended particulate matter obtained from four depth intervals ( approximately 70, 500, 1,000 and 1,500 m) at seven stations in ..
  61. doi Membrane integration of a mitochondrial signal-anchored protein does not require additional proteinaceous factors
    Elisa Merklinger
    Interfaculty Institute of Biochemistry, University of Tubingen, Hoppe Seyler Strasse 4, Tubingen, Germany
    Biochem J 442:381-9. 2012
    ..Collectively, our results suggest that SA proteins are specifically inserted into the MOM by a process that is not dependent on additional proteins, but is rather facilitated by the distinct lipid composition of this membrane...
  62. ncbi Bacterial membrane lipids: where do we stand?
    John E Cronan
    Department of Microbiology, University of Illinois, Urbana, Illinois 61801, USA
    Annu Rev Microbiol 57:203-24. 2003
    ..This review concentrates on the phospholipid synthetic pathway and discusses recent data on the synthesis and function of phospholipids mainly in the bacterium Escherichia coli...
  63. ncbi LiaRS-dependent gene expression is embedded in transition state regulation in Bacillus subtilis
    Sina Jordan
    Department of General Microbiology, Georg August University, 37077 Gottingen, Germany
    Microbiology 153:2530-40. 2007
    ..The activity of the liaI promoter is therefore tightly regulated by at least five regulators to ensure an appropriate level of liaIH expression...
  64. doi Interaction of articaine hydrochloride with prokaryotic membrane lipids
    Henning Lygre
    Department of Medicine, Section of Pharmacology, University of Bergen, Bergen, Norway
    Acta Odontol Scand 67:1-7. 2009
    ..Additionally, articaine has recently been used as an alkaline component in endodontic materials with a proposed antibacterial activity. However, the detailed mechanisms of action have not been discussed...
  65. ncbi Role of cholesterol and lipid organization in disease
    Frederick R Maxfield
    Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Nature 438:612-21. 2005
    b>Membrane lipids are essential for biological functions ranging from membrane trafficking to signal transduction...
  66. pmc Lipid lateral diffusion in ordered and disordered phases in raft mixtures
    Andrey Filippov
    Department of Biophysical Chemistry, Umea University, SE 901 87 Umea, Sweden
    Biophys J 86:891-6. 2004
    ..This means that on the millisecond timescale fluid, ordered domains are floating around in a sea of faster diffusing lipids, assigned to consist of mainly dioleoylphosphatidylcholine...
  67. pmc A distinct type of glycerol-3-phosphate acyltransferase with sn-2 preference and phosphatase activity producing 2-monoacylglycerol
    Weili Yang
    Department of Plant Biology, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 107:12040-5. 2010
    ..These results provide insight into the biosynthetic assembly of cutin and suberin, the two most abundant glycerolipid polymers in nature...
  68. pmc In-depth profiling of the LiaR response of Bacillus subtilis
    Diana Wolf
    Department of Biology I, Ludwig Maximilians University of Munich, Grosshaderner Str 2 4, D 82152 Planegg Martinsried, Germany
    J Bacteriol 192:4680-93. 2010
    ..Our data suggest that the LiaFSR system of B. subtilis and, presumably, other Firmicutes bacilli coordinates a phage shock protein-like response...
  69. ncbi The beta-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the alpha7 nicotinic acetylcholine receptor
    David H Small
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
    J Neurochem 101:1527-38. 2007
    ..Instead, we speculate that Abeta may exert its effects by altering the packing of lipids within the plasma membrane, which could, in turn, influence the function of a variety of receptors and channels on the cell surface...
  70. ncbi Amphiphilic sites for general anesthetic action? Evidence from 129Xe-[1H] intermolecular nuclear Overhauser effects
    Y Xu
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, PA 15261, USA
    Biochim Biophys Acta 1323:154-62. 1997
    ..This result may suggest the importance of amphiphilicity in association with anesthetic action...
  71. ncbi How lipids and proteins interact in a membrane: a molecular approach
    Anthony G Lee
    School of Biological Sciences, University of Southampton, Southampton, UK
    Mol Biosyst 1:203-12. 2005
    ..Evidence is also accumulating for the presence of 'co-factor' lipid molecules binding with high specificity to membrane proteins, often between transmembrane alpha-helices, and often being essential for activity...
  72. ncbi Putative ammonia-oxidizing Crenarchaeota in suboxic waters of the Black Sea: a basin-wide ecological study using 16S ribosomal and functional genes and membrane lipids
    Marco J L Coolen
    Royal Netherlands Institute for Sea Research, Department of Marine Biogeochemistry and Toxicology, PO Box 59, 1790 AB Den Burg, The Netherlands
    Environ Microbiol 9:1001-16. 2007
    ..These results indicate an abundance of putative nitrifying Archaea at very low oxygen levels within the Black Sea and might form an important source of nitrite for the anammox reaction...
  73. ncbi Membrane-insertion fragments of Bcl-xL, Bax, and Bid
    Ana J García-Sáez
    Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, Spain
    Biochemistry 43:10930-43. 2004
    ..Thus, the above fragments should be considered for the definition of plausible models of the active, membrane-bound species of Bcl-2 proteins...
  74. doi Early evolution of membrane lipids: how did the lipid divide occur?
    Yosuke Koga
    J Mol Evol 72:274-82. 2011
    ..This can explain why the extant archaeal and bacterial membrane lipids are mainly composed by Ai and Bf lipids, respectively...
  75. pmc Membrane lipids in invadopodia and podosomes: key structures for cancer invasion and metastasis
    Hideki Yamaguchi
    Growth Factor Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Oncotarget 1:320-8. 2010
    ..This review will summarize recent progress on the molecular mechanisms of invadopodia/podosome formation, with strong emphasis on the roles of lipid rafts and phosphoinositides...
  76. pmc Transcriptional regulation in bacterial membrane lipid synthesis
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Lipid Res 50:S115-9. 2009
    ....
  77. ncbi Molecular activity of Na(+)/K(+)-ATPase from different sources is related to the packing of membrane lipids
    B J Wu
    Metabolic Research Centre, Department of Biomedical Science, University of Wollongong, Wollongong, NSW 2522, Australia
    J Exp Biol 204:4271-80. 2001
    ..The membrane lipids surrounding this enzyme were isolated and phospholipids prepared...
  78. doi Membrane lipid modification by polyunsaturated fatty acids sensitizes oligodendroglial OLN-93 cells against oxidative stress and promotes up-regulation of heme oxygenase-1 (HSP32)
    Annette Brand
    Institute of Brain Chemistry and Human Nutrition School of Medicine, London Metropolitan University, N7 8DB London, UK
    J Neurochem 113:465-76. 2010
    ..Enrichment with higher omega-3, -6 and -9 PUFA and an increase in the biosynthesis rate of very long chain fatty acids, mainly changed the FA profile of ethanolamine and serine phosphoglycerides...
  79. doi Membranes: a meeting point for lipids, proteins and therapies
    Pablo V Escriba
    Laboratory of Molecular Cell Biomedicine, Dept of Biology IUNICS, University of the Balearic Islands, Palma de Mallorca, Spain
    J Cell Mol Med 12:829-75. 2008
    ..b>Membrane lipids are crucial in the fission and fusion of lipid bilayers and they also act as sensors to control environmental ..
  80. doi Cutin deficiency in the tomato fruit cuticle consistently affects resistance to microbial infection and biomechanical properties, but not transpirational water loss
    Tal Isaacson
    Department of Plant Biology, Cornell University, Ithaca, NY 14853, USA
    Plant J 60:363-77. 2009
    ..The three cd mutations were mapped to different loci, and the cloning of CD2 revealed it to encode a homeodomain protein, which we propose acts as a key regulator of cutin biosynthesis in tomato fruit...
  81. ncbi T lymphocyte costimulation mediated by reorganization of membrane microdomains
    A Viola
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Science 283:680-2. 1999
    ..These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains...
  82. doi Lipidomics reveals membrane lipid remodelling and release of potential lipid mediators during early stress responses in a murine melanoma cell line
    Gabor Balogh
    Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary
    Biochim Biophys Acta 1801:1036-47. 2010
    ....
  83. doi Mechanisms of membrane curvature sensing
    Bruno Antonny
    Université de Nice Sophia Antipolis and Centre National de la Recheche Scientifique, Institut de Pharmacologie Moleculaire et Cellulaire, 06560 Valbonne, France
    Annu Rev Biochem 80:101-23. 2011
    ..Membrane curvature sensors help to organize very diverse reactions, such as lipid transfer between membranes, the tethering of vesicles at the Golgi apparatus, and the assembly-disassembly cycle of protein coats...
  84. pmc Cryptococcus neoformans cryoultramicrotomy and vesicle fractionation reveals an intimate association between membrane lipids and glucuronoxylomannan
    Debora L Oliveira
    Laboratorio de Estudos Integrados em Bioquimica Microbiana, Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941590, Brazil
    Fungal Genet Biol 46:956-63. 2009
    ..These results indicate an intimate association of GXM and lipids in both intracellular and extracellular spaces consistent with polysaccharide synthesis and transport in membrane-associated structures...
  85. doi Regulation of the NPC2 protein-mediated cholesterol trafficking by membrane lipids
    Hichem D Gallala
    LIMES, Membrane Biology and Lipid Biochemistry Unit, Kekule Institut fur Organische Chemie und Biochemie, Universitat Bonn, Bonn, Germany
    J Neurochem 116:702-7. 2011
    ..degraded, we have to investigate the complex interactions that take place in this compartment between complex membrane lipids, enzymes and lipid binding and transfer proteins involved...
  86. doi How curved membranes recruit amphipathic helices and protein anchoring motifs
    Nikos S Hatzakis
    Bio Nanotechnology Laboratory, Department of Neuroscience and Pharmacology and Nano Science Center, University of Copenhagen, Copenhagen, Denmark
    Nat Chem Biol 5:835-41. 2009
    ..We therefore anticipate that MC will promote the redistribution of proteins that are anchored in membranes through other types of hydrophobic moieties...
  87. ncbi Roles of lipid polymorphism in intracellular delivery
    I M Hafez
    Department of Biochemistry and Molecular Biology, University of British Columbia, 2146 Health Sciences Mall, British Columbia V6T 1Z3, Vancouver, Canada
    Adv Drug Deliv Rev 47:139-48. 2001
    ....
  88. pmc Fast molecular tracking maps nanoscale dynamics of plasma membrane lipids
    Steffen J Sahl
    Department of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 107:6829-34. 2010
    ..Our experimental approach demonstrates that fast molecular movements can be tracked with minimal invasion, which can reveal new important details of cellular nano-organization...
  89. pmc Interaction of quorum signals with outer membrane lipids: insights into prokaryotic membrane vesicle formation
    Lauren Mashburn-Warren
    The University of Texas at Austin, Austin, TX 78712, USA
    Mol Microbiol 69:491-502. 2008
    ..Finally, we show that PQS stimulated purified LPS to form liposome-like structures. These studies provide molecular insight into P. aeruginosa MV formation and demonstrate that quorum signals serve important non-signalling functions...
  90. pmc The control of transmembrane helix transverse position in membranes by hydrophilic residues
    Shyam S Krishnakumar
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794 5215, USA
    J Mol Biol 374:1251-69. 2007
    ..Knowledge of the magnitudes of transverse shifts induced by different hydrophilic residues should be useful for design of mutagenesis studies measuring the effect of transverse TM helix position upon function...
  91. doi Strategies for the cell-free expression of membrane proteins
    Sina Reckel
    Centre for Biomolecular Magnetic Resonance, Institute for Biophysical Chemistry, University of Frankfurt Main, Frankfurt Main, Germany
    Methods Mol Biol 607:187-212. 2010
    ..We provide protocols for the cell-free expression of membrane proteins in different modes including their expression as precipitate as well as their direct synthesis into detergent micelles or lipid bilayers...
  92. pmc Arabidopsis AtGPAT1, a member of the membrane-bound glycerol-3-phosphate acyltransferase gene family, is essential for tapetum differentiation and male fertility
    Zhifu Zheng
    Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan S7N OW9, Canada
    Plant Cell 15:1872-87. 2003
    ..Deficiency in AtGPAT1 correlates with several fatty acid composition changes in flower tissues and seeds. Unexpectedly, however, a loss of AtGPAT1 causes no significant change in seed oil content...
  93. pmc Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion
    Misbaudeen Abdul-Hammed
    Membrane Biology and Biochemistry Unit, Life and Medical Sciences Institute LIMES, Bonn, Germany
    J Lipid Res 51:1747-60. 2010
    ..Note that the effects of the lipids on cholesterol transfer mediated by NPC2 were similar to their effect on membrane fusion induced by NPC2 and saposin-C...
  94. ncbi A modeling framework describing the enzyme regulation of membrane lipids underlying gradient perception in Dictyostelium cells
    J Krishnan
    Department of Electrical and Computer Engineering, Johns Hopkins University, 105 Barton Hall, 3400 N Charles St, Baltimore, MD 21218, USA
    J Theor Biol 229:85-99. 2004
    ..An analysis of a basic module underlying this process is also performed...
  95. pmc Active fragments from pro- and antiapoptotic BCL-2 proteins have distinct membrane behavior reflecting their functional divergence
    Yannis Guillemin
    Institut de Biologie et Chimie des Protéines IBCP, CNRS UMR5086, University of Lyon, Lyon, France
    PLoS ONE 5:e9066. 2010
    ..Although the association of these proteins with the outer mitochondrial membrane is crucial for their function, little is known about the characteristics of this interaction...
  96. ncbi N-3 polyunsaturated fatty acids impair lifespan but have no role for metabolism
    Teresa G Valencak
    Research Institute of Wildlife Ecology, University of Veterinary Medicine, Savoyenstrasse 1, A 1160 Vienna, Austria
    Aging Cell 6:15-25. 2007
    ..These results contradict the 'membrane pacemaker theory of aging', that is, the concept of a direct link between high amounts of membrane PUFAs, elevated BMR, and thus, impaired longevity...
  97. pmc Spin-labeled gramicidin a: channel formation and dissociation
    Boris G Dzikovski
    Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14583 1301, USA
    Biophys J 87:3504-17. 2004
    ..4-1 mol %) accessible to the ESR methods employed in the study, since this yields non-interacting dimer channels...
  98. pmc Molecular dynamics simulations of hydrophilic pores in lipid bilayers
    Hari Leontiadou
    Department of Biophysical Chemistry, University of Groningen, Nijenborgh, Groningen, The Netherlands
    Biophys J 86:2156-64. 2004
    ..In the simulations the mechanical threshold tension necessary to cause rupture of the membrane on a nanosecond timescale is much higher in the case of the equilibrated bilayers, as compared with membranes containing preexisting pores...
  99. pmc Analyzing heat capacity profiles of peptide-containing membranes: cluster formation of gramicidin A
    V P Ivanova
    Membrane Biophysics and Thermodynamics Group, Max Planck Institute for Biophysical Chemistry, 37070 Gottingen, Germany
    Biophys J 84:2427-39. 2003
    ..On the basis of these findings we described the effect of proteins on local fluctuations. It is shown that the elastic properties of the membrane are influenced in the peptide environment...
  100. pmc Membrane insertion and bilayer perturbation by antimicrobial peptide CM15
    Sara Pistolesi
    Department of Biophysics and National Biomedical Electron Paramagnetic Resonance Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Biophys J 93:1651-60. 2007
    ..spin labels to assess the effects of CM15 binding and accumulation on the physical properties of membrane lipids. We find that as the concentration of membrane-bound CM15 is increased the N-terminal domain of the peptide ..
  101. ncbi Molecular mechanism for lipid flip-flops
    Andrey A Gurtovenko
    Computational Laboratory, Institute of Pharmaceutical Innovation, University of Bradford, Bradford, West Yorkshire, BD7 1DP, United Kingdom
    J Phys Chem B 111:13554-9. 2007
    ....

Research Grants73

  1. Mapping for Specialized Domains for FCeRI Signaling & Internalization
    Bridget S Wilson; Fiscal Year: 2010
    ..In Aim 1, we will develop new monovalent probes for plasma membrane lipids. We will use both transmission and X- ray spectral electron microscopy to map the distributions of tagged ..
  2. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS contact KIRKWOOD; Fiscal Year: 2010
    ..that 4-hydroxynonenal (HNE), an aldehyde generated by the action of reactive oxygen species (ROS) on membrane lipids, is an endogenous agonist of TRPA1 which causes peptide release, neurogenic inflammation and pain...
  3. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS contact KIRKWOOD; Fiscal Year: 2010
    ..that 4-hydroxynonenal (HNE), an aldehyde generated by the action of reactive oxygen species (ROS) on membrane lipids, is an endogenous agonist of TRPA1 which causes peptide release, neurogenic inflammation and pain...
  4. Unique Isoprenoid Biosynthesis Machinery of the Hyperthermophilic Archaea
    HAROLD MONBOUQUETTE; Fiscal Year: 2007
    ..The archaea necessarily have higher throughput isoprenoid biosynthesis machinery; as their membrane lipids are based solely on branched-chain, saturated hydrocarbons condensed with polyol (usually glycerol)-based ..
  5. LEUKOTRIENES AND MESSENGERS IN PHOTORECEPTOR RENEWAL
    Nicolas Bazan; Fiscal Year: 1993
    This proposal is the continuation of our studies on second messenger systems derived from membrane lipids involved in retinal pigment epithelium - visual cell interactions during photoreceptor renewal...
  6. LIPID MODULATION OF RHODOPSIN SIGNALING IN MEMBRANES
    Michael F Brown; Fiscal Year: 2010
    ..Biophysical methods will characterize the influences of membrane lipids on the Meta I}Meta II transition of rhodopsin...
  7. LIPID MODULATION OF RHODOPSIN SIGNALING IN MEMBRANES
    Michael Brown; Fiscal Year: 2009
    ..Biophysical methods will characterize the influences of membrane lipids on the Meta I}Meta II transition of rhodopsin...
  8. MODULATION OF KERATINOCYTE GROWTH AND SPECIALIZATION
    CYNTHIA MARCELO; Fiscal Year: 1993
    ..The aims are first, to determine if marked changes occur in other key membrane lipids of these cells (sterols, sphingolipids)...
  9. OXIDATIVE CELL INJURY: FIRST-EPISODE PSYCHOTIC PATIENTS
    Sahebarao Mahadik; Fiscal Year: 2002
    ..Effects of oxidative cell injury will be examined in lymphocyte plasma membrane lipids, mitochondrial membranes, cellular proteins, and DNA (both Mitochondrial and nuclear)...
  10. Prostate MRI and MRS: Correlations with Gene Expression
    Sandra Gaston; Fiscal Year: 2007
    ..kinase (the first and probably regulatory enzyme in the pathway for de novo synthesis of choline containing membrane lipids) in tissue-print micro-peels obtained from radical prostatectomy specimens containing Gleason grade 6,7 or 8 ..
  11. PERMEABILITY OF THE LUNG TO WATER SOLUBLE SOLUTES
    EVELINE SCHNEEBERGER; Fiscal Year: 1990
    ..The role of membrane lipids in tight junction formation, structure and function will be examined in epithelial cells cultured in vitro ..
  12. SORTING OF A LIPID-PROTEIN COMPLEX IN EPITHELIAL CELLS
    Deborah Brown; Fiscal Year: 1993
    ..Plasma membrane proteins and some membrane lipids are sorted in the trans Golgi network in certain cultured epithelial cells, and are packaged into transport ..
  13. MEMBRANE PATHOLOGY IN RENAL CELL INJURY
    Manjeri Venkatachalam; Fiscal Year: 1993
    ..The major thrust of the effort will be to study how catabolism of membrane lipids relates to membrane damage...
  14. NMR STUDIES OF CYTOSOLIC METAL IONS AND OXIDATIVE STRESS
    Raj Gupta; Fiscal Year: 2006
    ..We seek to understand how the regulation of intracellular concentrations of essential metal ions and membrane lipids goes astray in health disorders, especially hypertension and diabetes...
  15. Vasodilation via selective pharmacological targeting of BK channel beta1 subunits
    Alex M Dopico; Fiscal Year: 2010
    ..activate BK via specific docking on the channel or, rather, secondarily to nonspecific perturbation of membrane lipids. We recently found that cholane steroids, such as lithocholate (LC), selectively activate 21-containing BK, ..
  16. PROTEINS OF NORMAL AND CATARACTOUS LENSES
    FRANK GIBLIN; Fiscal Year: 2005
    ..in vitro, mass spectrometry and infrared spectroscopy to investigate oxidative effects on lens proteins and membrane lipids, and to identify crystallins that have precipitated in the lens because of in vivo oxidative stress...