chylomicrons

Summary

Summary: A class of lipoproteins that carry dietary cholesterol and triglycerides from the small intestines to the tissues.

Top Publications

  1. ncbi Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons
    Anne P Beigneux
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, and Children s Hospital Oakland Research Institute 94609, USA
    Cell Metab 5:279-91. 2007
  2. ncbi Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells
    Alexandrine During
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Lipid Res 48:2283-94. 2007
  3. ncbi Carboxyl ester lipase overexpression in rat hepatoma cells and CEL deficiency in mice have no impact on hepatic uptake or metabolism of chylomicron-retinyl ester
    A M Van Bennekum
    Department of Biochemistry, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19129, USA
    Biochemistry 38:4150-6. 1999
  4. ncbi Development and physiological regulation of intestinal lipid absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons
    Charles M Mansbach
    Division of Gastroenterology, The Univ of Tennessee Health Science Center, 920 Madison Ave, Suite 240, Memphis, TN 38163, USA
    Am J Physiol Gastrointest Liver Physiol 293:G645-50. 2007
  5. ncbi The biogenesis of chylomicrons
    Charles M Mansbach
    The University of Tennessee Health Science Center and the Veterans Administration Medical Center, Memphis, TN 38163, USA
    Annu Rev Physiol 72:315-33. 2010
  6. ncbi Plasma clearance and liver uptake of chylomicron remnants generated by hepatic lipase lipolysis: evidence for a lactoferrin-sensitive and apolipoprotein E-independent pathway
    S E Crawford
    Department of Pathology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Lipid Res 40:797-805. 1999
  7. ncbi Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons
    Emile Levy
    Department of Nutrition, Hôpital Sainte Justine and University of Montreal, Montreal, Quebec H3T 1C5, Canada
    J Biol Chem 277:16470-7. 2002
  8. ncbi Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia
    Gunilla Olivecrona
    Department of Medical Biosciences Physiological Chemistry, Umea University, Umea, Sweden
    J Lipid Res 51:1535-45. 2010
  9. ncbi Scavenger receptor BI plays a role in facilitating chylomicron metabolism
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, 2300 RA Leiden, The Netherlands
    J Biol Chem 279:18401-6. 2004
  10. ncbi Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects
    Remco Franssen
    Department of Vascular Medicine, Academic Medical Center Amsterdam, The Netherlands
    Circ Cardiovasc Genet 3:169-78. 2010

Research Grants

  1. METABOLISM OF INTRAVENOUS LIPID EMULSIONS
    Richard Deckelbaum; Fiscal Year: 2007
  2. ATHEROSCLEROSIS AND PERIPHERAL APOPROTEIN E SYNTHESIS
    David Williams; Fiscal Year: 1999
  3. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2003
  4. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2010
  5. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2004
  6. DIETARY CAROTENOIDS - LIPOPROTEIN/CELL INTERACTIONS
    EARL HARRISON; Fiscal Year: 2005
  7. Interactions of Lipoproteins with the Vascular Wall
    JOHN CALVERT RUTLEDGE; Fiscal Year: 2010
  8. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 1999
  9. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
  10. MPT INHIBITOR IND 50,820 IN FAMILIAL HYPERCHOLESTEROLEM*
    Marina Cuchel; Fiscal Year: 2009

Detail Information

Publications193 found, 100 shown here

  1. ncbi Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons
    Anne P Beigneux
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, and Children s Hospital Oakland Research Institute 94609, USA
    Cell Metab 5:279-91. 2007
    The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LpL) along the luminal surface of the capillaries. However, the endothelial cell molecule that facilitates chylomicron processing by LpL has not yet been defined...
  2. ncbi Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells
    Alexandrine During
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Lipid Res 48:2283-94. 2007
    ..efflux into basolateral medium (BM) increased linearly with time, ROL in the nonlipoprotein fraction and REs in chylomicrons (CMs). In contrast to carotenoids, ROL uptake was proportional to ROL concentration (0.5-110 microM)...
  3. ncbi Carboxyl ester lipase overexpression in rat hepatoma cells and CEL deficiency in mice have no impact on hepatic uptake or metabolism of chylomicron-retinyl ester
    A M Van Bennekum
    Department of Biochemistry, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19129, USA
    Biochemistry 38:4150-6. 1999
    ....
  4. ncbi Development and physiological regulation of intestinal lipid absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons
    Charles M Mansbach
    Division of Gastroenterology, The Univ of Tennessee Health Science Center, 920 Madison Ave, Suite 240, Memphis, TN 38163, USA
    Am J Physiol Gastrointest Liver Physiol 293:G645-50. 2007
    ..aspects of this process from the mechanisms of fatty acid uptake to the control of triacylglycerol export in chylomicrons. Recent advances have included the identification of a number of fatty acid transporters, the discovery of ..
  5. ncbi The biogenesis of chylomicrons
    Charles M Mansbach
    The University of Tennessee Health Science Center and the Veterans Administration Medical Center, Memphis, TN 38163, USA
    Annu Rev Physiol 72:315-33. 2010
    ....
  6. ncbi Plasma clearance and liver uptake of chylomicron remnants generated by hepatic lipase lipolysis: evidence for a lactoferrin-sensitive and apolipoprotein E-independent pathway
    S E Crawford
    Department of Pathology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Lipid Res 40:797-805. 1999
    b>Chylomicrons labeled with [3H]cholesterol and [14C]triglyceride fatty acids were lipolyzed by hepatic lipase (HL) in vitro and then injected intravenously into normal mice fed low- or high-fat diets, and into apolipoprotein (apo) E-..
  7. ncbi Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons
    Emile Levy
    Department of Nutrition, Hôpital Sainte Justine and University of Montreal, Montreal, Quebec H3T 1C5, Canada
    J Biol Chem 277:16470-7. 2002
    ..The occurrence of membrane-associated apoB in the Golgi, coupled with its interaction with active MTP, suggests an important role for the Golgi in the biogenesis of apoB-containing lipoproteins...
  8. ncbi Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia
    Gunilla Olivecrona
    Department of Medical Biosciences Physiological Chemistry, Umea University, Umea, Sweden
    J Lipid Res 51:1535-45. 2010
    ..Thus, the conserved cysteines in the Ly6 domain are crucial for GPIHBP1 function...
  9. ncbi Scavenger receptor BI plays a role in facilitating chylomicron metabolism
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, 2300 RA Leiden, The Netherlands
    J Biol Chem 279:18401-6. 2004
    ....
  10. ncbi Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects
    Remco Franssen
    Department of Vascular Medicine, Academic Medical Center Amsterdam, The Netherlands
    Circ Cardiovasc Genet 3:169-78. 2010
    ....
  11. ncbi COPII proteins are required for Golgi fusion but not for endoplasmic reticulum budding of the pre-chylomicron transport vesicle
    Shadab A Siddiqi
    Division of Gastroenterology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Cell Sci 116:415-27. 2003
    ..Together, these findings suggest that COPII proteins may not be required for the exit of membrane-bound chylomicrons from the ER but that they or other proteins may be necessary for PCTV fusion with the Golgi.
  12. ncbi The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins
    Peter J O'Brien
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Clin Chem 51:351-9. 2005
    ..Despite these compelling molecular biology data, relatively little is known about ApoA5 protein in human serum...
  13. ncbi Anderson or chylomicron retention disease: molecular impact of five mutations in the SAR1B gene on the structure and the functionality of Sar1b protein
    Mathilde Charcosset
    UF Lipides Dyslipidémies, Laboratoire de Biochimie, CBE, 59 Boulevard Pinel, Bron Cedex, France
    Mol Genet Metab 93:74-84. 2008
    ..A determination of the specific mutation in Anderson disease or CMRD is required to ensure diagnosis and allow prompt therapeutic intervention in these children...
  14. ncbi Variable phenotypic expression of chylomicron retention disease in a kindred carrying a mutation of the Sara2 gene
    Angelo B Cefalù
    Departmet of Clinical Medicine and Emerging Diseases, University of Palermo, I 90127 Palermo, Italy
    Metabolism 59:463-7. 2010
    ..More studies are needed to understand the reasons of the phenotypic variability of the same molecular defect in the same family...
  15. ncbi Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Biochim Biophys Acta 1771:1464-8. 2007
    ..A hallmark of GPIHBP1 is the ability to bind lipoprotein lipase, chylomicrons, and apolipoprotein (apo-) AV...
  16. ncbi A proposed model for the assembly of chylomicrons
    M M Hussain
    Department of Biochemistry, School of Medicine, MCP Hahnemann University, Philadelphia, PA 19129, USA
    Atherosclerosis 148:1-15. 2000
    The intestine synthesizes very low density lipoproteins (VLDL) and chylomicrons (CM) to transport fat and fat-soluble vitamins into the blood...
  17. ncbi Vitamin A intake affects the contribution of chylomicrons vs. retinol-binding protein to milk vitamin A in lactating rats
    M H Green
    Nutrition Department, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 131:1279-82. 2001
    To investigate the influence of vitamin A intake on the contribution of chylomicrons vs...
  18. ncbi Size distributions of chylomicrons from human lymph from dynamic light scattering measurements
    H Ruf
    Max Planck Institut fur Biophysik, Frankfurt a M, Germany
    Eur Biophys J 28:1-11. 1999
    b>Chylomicrons, the vehicles for the transport of exogeneous triglycerides and cholesterol in the lymph and the blood, were characterized by their size from dynamic light scattering measurements...
  19. ncbi Incorporation of carotenoids from paprika oleoresin into human chylomicrons
    Antonio Pérez-Gálvez
    Institute for Physiological Chemistry I, Henrich Heine University Düsseldorf, Dusseldorf, Germany
    Br J Nutr 89:787-93. 2003
    ..However, oleoresin is a suitable source for the provitamin A carotenoids beta-carotene and beta-cryptoxanthin and the macular pigment zeaxanthin...
  20. ncbi Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 29:956-62. 2009
    GPIHBP1 is an endothelial cell protein that binds lipoprotein lipase (LPL) and chylomicrons. Because GPIHBP1 deficiency causes chylomicronemia in mice, we sought to determine whether some cases of chylomicronemia in humans could be ..
  21. ncbi Uptake of lipophilic drugs by plasma derived isolated chylomicrons: linear correlation with intestinal lymphatic bioavailability
    Pavel Gershkovich
    Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, P.O. Box 12065, 91120 Jerusalem, Israel
    Eur J Pharm Sci 26:394-404. 2005
    Association of a drug with chylomicrons in the enterocyte is an essential step in the lymphatic absorption pathway...
  22. ncbi Postprandial chylomicrons: potent vehicles for transporting cholesterol from endogenous LDL+HDL and cell membranes to the liver via LCAT and CETP
    Byung Hong Chung
    Atherosclerosis Research Unit, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Lipid Res 45:1242-55. 2004
    We examined whether postprandial (PP) chylomicrons (CMs) can serve as vehicles for transporting cholesterol from endogenous cholesterol-rich lipoprotein (LDL+HDL) fractions and cell membranes to the liver via lecithin:cholesterol ..
  23. ncbi Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation
    F Karpe
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK
    Biochem Soc Trans 35:472-6. 2007
    The triacylglycerol content of chylomicrons and VLDL (very-low-density lipoprotein) compete for the same lipolytic pathway in the capillary beds...
  24. ncbi Are we ready for a prospective study to investigate the role of chylomicrons in cardiovascular disease?
    Jeffrey S Cohn
    Nutrition and Metabolism Group, Heart Research Institute, 114 Pyrmont Bridge Road, Camperdown, NSW 2050, Australia
    Atheroscler Suppl 9:15-8. 2008
    Intestinal chylomicrons and their remnants are believed to contribute both directly and indirectly to the onset and development of atherosclerosis...
  25. ncbi Metabolism of very-low-density lipoprotein and chylomicrons by streptozotocin-induced diabetic rat heart: effects of diabetes and lipoprotein preference
    You Guo Niu
    Department of Clinical Aerospace Medicine, The Fourth Military Medical University, Xi an, China
    Am J Physiol Endocrinol Metab 295:E1106-16. 2008
    Very-low-density lipoprotein (VLDL) and chylomicrons (CM) are major sources of fatty acid supply to the heart, but little is known about their metabolism in diabetic myocardium...
  26. ncbi Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage
    Toralph Ruge
    Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford OX3 7LJ, United Kingdom
    J Clin Endocrinol Metab 94:1781-8. 2009
    ..Adipose tissue sequesters dietary fat and thus protects other tissues from excess fat exposure, especially after meals...
  27. ncbi Normotriglyceridemic abetalipoproteinemia. absence of the B-100 apolipoprotein
    M J Malloy
    J Clin Invest 67:1441-50. 1981
    ..and very low density lipoproteins are absent, but in which triglycerides are absorbed from the intestine and chylomicrons are present in plasma...
  28. ncbi Decreased hepatic expression of the low-density lipoprotein (LDL) receptor and LDL receptor-related protein in aging rats is associated with delayed clearance of chylomicrons from the circulation
    P A Field
    Metabolic Research Laboratory, Oxford Lipid Metabolism Group, University of Oxford, UK
    Metabolism 49:492-8. 2000
    ..intravenously injected bolus of 14C-labeled cholesterol ester (CE) and 3H-labeled triacylglycerol (TAG) lymph chylomicrons was markedly delayed in the old rats (P < .05)...
  29. ncbi Fibrinogen in rat gastrointestinal lymph before, during and after intraduodenal administration of emulsified triglyceride: fibrinogen bound to chylomicrons in gastrointestinal lymph is functional
    Ashley P DeAnglis
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267-0529, USA
    Thromb Res 105:419-32. 2002
    ..Levels of the same analytes changed little, if at all, in control animals. As assessed using immunoblotting, chylomicrons in gastrointestinal lymph are coated with fibrinogen...
  30. ncbi The diurnal rhythms of cholesterol metabolism and plasma clearance of model chylomicrons: comparison of normal and genetically hypercholesterolemic rats (RICO)
    B C Mortimer
    Department of Physiology, University of Western Australia, Nedlands, Australia
    Comp Biochem Physiol A Mol Integr Physiol 120:671-80. 1998
    Previous studies showed a slower clearance of cholesterol-labeled lymph chylomicrons in genetically hypercholesterolemic rats (RICO) compared with normocholesterolemic rats...
  31. ncbi Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia
    J R Wetterau
    Department of Metabolic Diseases, Bristol Myers Squibb, Princeton, NJ 08543 4000
    Science 258:999-1001. 1992
    ..that is characterized by a defect in the assembly or secretion of plasma very low density lipoproteins and chylomicrons. The microsomal triglyceride transfer protein (MTP), which is located in the lumen of microsomes isolated from ..
  32. ncbi Postprandial dyslipidemia in men with visceral obesity: an effect of reduced LDL receptor expression?
    J C Mamo
    Department of Nutrition, Dietetics and Food Sciences, School of Public Health, Curtin University of Technology, Perth 6845, Australia
    Am J Physiol Endocrinol Metab 281:E626-32. 2001
    ..ml(-1). h; RP: 3,120 +/- 511 vs. 1,308 +/- 177 U. ml(-1). h, respectively). A delay in the conversion of chylomicrons to remnants probably contributed to postprandial dyslipidemia in viscerally obese subjects...
  33. ncbi Glibenclamide improves postprandial hypertriglyceridaemia in type 2 diabetic patients by reducing chylomicrons but not the very low-density lipoprotein subfraction levels
    I Skrapari
    1st Department Propaedeutic Medicine, Athens University Medical School, Laiko General Hospital, Athens, Greece
    Diabet Med 18:781-5. 2001
    ..Total triglyceride levels in plasma, in chylomicrons (CM), in CM-deficient plasma, in very low-density lipoprotein (VLDL) subfractions (VLDL-1, VLDL-2) and in ..
  34. ncbi Effects of palm oil and transesterified palm oil on chylomicron and VLDL triacylglycerol structures and postprandial lipid response
    K Yli-Jokipii
    Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014 Turku, Finland
    J Lipid Res 42:1618-25. 2001
    The effects of positional distribution of triacylglycerol (TAG) fatty acids to TAG structures in chylomicrons and VLDL, and to postprandial lipemia, were studied in 10 healthy premenopausal women using a 6-h oral fat load test and a ..
  35. ncbi Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders
    Bethan Jones
    Genomic and Molecular Medicine Group, MRC Clinical Sciences Centre, Imperial College, London, England, UK
    Nat Genet 34:29-31. 2003
    ..Our data suggest that chylomicrons, which vastly exceed the size of typical COPII vesicles, are selectively recruited by the COPII machinery for ..
  36. ncbi Signposts in the assembly of chylomicrons
    M M Hussain
    Departments of Anatomy and Cell Biology, and Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Front Biosci 6:D320-31. 2001
    Intestinal cells synthesize and secrete chylomicrons in the postprandial state. Synthesis of these particles is defective in abetalipoproteinemia and chylomicron retention disease...
  37. ncbi The incorporation and metabolism of amyloid-beta into chylomicron-like lipid emulsions
    Anthony P James
    Department of Nutrition, Dietetics and Food Science, Curtin University of Technology, Perth, Australia
    J Alzheimers Dis 5:179-88. 2003
    ..Chylomicron-like lipid emulsions, resembling chylomicrons in composition, size and metabolism were prepared in the presence of [125I]Abeta1-40...
  38. ncbi Effects of prior moderate exercise on exogenous and endogenous lipid metabolism and plasma factor VII activity
    J M Gill
    Human Muscle Metabolism Research Group, Loughborough University, Loughborough, LE113TU, UK
    Clin Sci (Lond) 100:517-27. 2001
    ....
  39. ncbi Mobilisation of enterocyte fat stores by oral glucose in humans
    M D Robertson
    Metabolic Research Group, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, UK
    Gut 52:834-9. 2003
    ..The aim of this study was to investigate the location and release of lipid from within the gastrointestinal tract...
  40. ncbi Effect of dietary fatty acids on the postprandial fatty acid composition of triacylglycerol-rich lipoproteins in healthy male subjects
    A Bysted
    BioCentrum DTU, Section of Biochemistry and Nutrition, Center of Advanced Food Studies, The Technical University of Denmark, Lyngby, Denmark
    Eur J Clin Nutr 59:24-34. 2005
    The aim of the present study was to investigate the effect of trans-18:1 isomers compared to other fatty acids, especially saturates, on the postprandial fatty acid composition of triacylglycerols (TAG) in chylomicrons and VLDL.
  41. ncbi The mechanism of the formation and secretion of chylomicrons
    Tammy Kindel
    University of Cincinnati College of Medicine, United States
    Atheroscler Suppl 11:11-6. 2010
    ..luminal digestion, followed by cellular uptake and processing, and subsequent extracellular transport of chylomicrons. We discuss the importance of acid and pancreatic lipase in lipid digestion...
  42. ncbi The elevation of ingested lipids within plasma chylomicrons is prolonged in men compared with women
    Nicolas D Knuth
    Substrate Metabolism Laboratory, Division of Kinesiology, University of Michigan, Ann Arbor, MI 48109-2214, USA
    J Nutr 136:1498-503. 2006
    ..The purpose of this study was to measure the recovery of ingested fat in plasma fractions of chylomicrons (CHYLO), VLDL, and plasma fatty acids, as well as in expired breath (i.e., oxidation) in men and women...
  43. ncbi Vegetable-borne lutein, lycopene, and beta-carotene compete for incorporation into chylomicrons, with no adverse effect on the medium-term (3-wk) plasma status of carotenoids in humans
    Viviane Tyssandier
    , INRA, Clermont-Ferrand/Theix, , France
    Am J Clin Nutr 75:526-34. 2002
    ..Carotenoids were measured in chylomicrons to assess the interaction of carotenoids on absorption...
  44. ncbi Chylomicron retention disease: a long term study of two cohorts
    Noel Peretti
    Department of Nutrition, CHU Sainte Justine, Universite de Montreal, GI Nutrition Unit, 3175 Ste Catherine Road, Montreal, Que, Canada
    Mol Genet Metab 97:136-42. 2009
    ..This study provides new insights on the phenotypic expression of CRD over time and emphasizes the need to screen the lipid profile of infants with chronic diarrhea and failure to thrive...
  45. ncbi Pluronic L81 enhances triacylglycerol accumulation in the cytosol and inhibits chylomicron secretion
    Sumbul Fatma
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    J Lipid Res 47:2422-32. 2006
    ..14C]PL81 inhibited the secretion of chylomicrons (CMs), lipoproteins essential for fat absorption, by differentiated Caco-2 cells similar to PL81...
  46. ncbi The intracellular transport of chylomicrons requires the small GTPase, Sar1b
    Carol C Shoulders
    Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Curr Opin Lipidol 15:191-7. 2004
    ..This review focuses on the assembly and structural evolution of COPII (coat protein) transport carriers that are essential for the transport of chylomicrons from the endoplasmic reticulum to the Golgi apparatus.
  47. ncbi Chylomicrons promote intestinal absorption and systemic dissemination of dietary antigen (ovalbumin) in mice
    Yuehui Wang
    Department of Internal Medicine, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 4:e8442. 2009
    ..contain long-chain triglycerides (LCT), which stimulate mesenteric lymph flux and postprandial transport of chylomicrons through mesenteric lymph nodes (MLN) and blood...
  48. ncbi Three-dimensional immunofluorescent double labelling using polyclonal antibodies derived from the same species: enterocytic colocalization of chylomicrons with Golgi apparatus
    R Takechi
    Australian Technology Centre for Metabolic Fitness, School of Public Health, Division of Health Sciences, Curtin University of Technology, GPO Box U1987, Perth, WA, 6845, Australia
    Histochem Cell Biol 129:779-84. 2008
    ..Colocalization of apo B and Golgi apparatus (75.2 +/- 8.5%) is consistent with the purported mode of secretion of these macromolecules...
  49. ncbi Chylomicron and VLDL TAG structures and postprandial lipid response induced by lard and modified lard
    Kaisa M Yli-Jokipii
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    Lipids 38:693-703. 2003
    ..were less TAG with palmitic acid in the sn-2 position and more TAG with oleic acid in the sn-2 position in chylomicrons than in fat ingested. From 1...
  50. ncbi Butter differs from olive oil and sunflower oil in its effects on postprandial lipemia and triacylglycerol-rich lipoproteins after single mixed meals in healthy young men
    Nadia Mekki
    , Human Nutrition and Lipids, National Institute of Health and Medical Research, , 13009 Marseille, France
    J Nutr 132:3642-9. 2002
    ..The butter meal induced a lower postprandial rise of triacylglycerols in serum and chylomicrons (incremental AUC, mmol.h/L: 0.72) than the two unsaturated oils (olive oil: 1.6, sunflower oil: 1...
  51. ncbi GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons
    Stephen G Young
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Curr Opin Lipidol 18:389-96. 2007
    To summarize recent data indicating that glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) plays a key role in the lipolytic processing of chylomicrons.
  52. ncbi The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 283:29554-62. 2008
    ..g. chylomicrons)...
  53. ncbi Effect of oxidized lipids in the diet on oxidized lipid levels in postprandial serum chylomicrons of diabetic patients
    I Staprans
    Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Diabetes Care 22:300-6. 1999
    ..To determine whether humans with type 2 diabetes have increased levels of oxidized fatty acids in their serum chylomicron fraction after the ingestion of dietary oxidized fatty acids...
  54. ncbi Vesicle-associated membrane protein 7 is expressed in intestinal ER
    Shadab A Siddiqi
    Division of Gastroenterology, The University of Tennessee Health Science Center, Memphis, TN 38163 USA
    J Cell Sci 119:943-50. 2006
    ..We conclude that VAMP7 is enriched in intestinal ER and that it plays a functional role in the delivery of triacylglycerol from the ER to the Golgi...
  55. ncbi Sitosterol and cholesterol in chylomicrons of type 2 diabetic and non-diabetic subjects: the relationship with ATP binding cassette proteins G5 and G8 and Niemann-Pick C1-like 1 mRNA
    S E Lally
    Diabetologia 50:217-9. 2007
  56. ncbi The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Mol Endocrinol 22:2496-504. 2008
    ..GPIHBP1 binds lipoprotein lipase and chylomicrons and is expressed along the luminal surface of microvascular endothelial cells...
  57. ncbi Retinyl ester secretion by intestinal cells: a specific and regulated process dependent on assembly and secretion of chylomicrons
    N Nayak
    Department of Biochemistry, School of Medicine, MCP Hahnemann University, Philadelphia, PA 19129, USA
    J Lipid Res 42:272-80. 2001
    ..We propose that RE are added to CM during final stages of lipoprotein assembly and may serve as signposts for these steps...
  58. ncbi Paraoxonase 1 (PON1) is present in postprandial chylomicrons
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 180:55-61. 2005
    ..As diet affects serum PON1 activity, we questioned whether PON1 is also carried by postprandial chylomicrons. Chylomicrons were isolated by ultracentrifugation from plasma of 10 healthy men, 3h after the consumption of a ..
  59. ncbi Chylomicrons promote intestinal absorption of lipopolysaccharides
    Sarbani Ghoshal
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, KY, USA
    J Lipid Res 50:90-7. 2009
    ..The Golgi complex also contains newly formed chylomicrons, the lipoproteins that transport dietary long-chain fat through mesenteric lymph and blood...
  60. ncbi Postprandial chylomicrons and adipose tissue lipoprotein lipase are altered in type 2 diabetes independently of obesity and whole-body insulin resistance
    Giovanni Annuzzi
    Department of Clinical and Experimental Medicine, Federico II University, Via Pansini 5, 80131 Naples, Italy
    Nutr Metab Cardiovasc Dis 18:531-8. 2008
    ..The aim of this study is to differentiate the effects of whole-body insulin resistance, obesity, and type 2 diabetes on postprandial dyslipidaemia and lipoprotein lipase (LPL) in adipose tissue...
  61. ncbi CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood
    Victor A Drover
    Department of Physiology and Biophysics, State University of New York at Stony Brook, USA
    J Clin Invest 115:1290-7. 2005
    ..CD36 deficiency results in hypertriglyceridemia both in the postprandial and fasting states and in humans may constitute a risk factor for diet-induced type 2 diabetes and cardiovascular disease...
  62. ncbi Intestinal lipoprotein assembly
    M Mahmood Hussain
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Curr Opin Lipidol 16:281-5. 2005
    ..In this review we propose a nomenclature for these lipoproteins and have summarized recent data about their intracellular assembly and factors that modulate their secretion...
  63. ncbi Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons
    Anita C E Vreugdenhil
    Nutrition and Toxicology Research Institute Maastricht, Department of General Surgery, Maastricht University, Maastricht, The Netherlands
    J Immunol 170:1399-405. 2003
    b>Chylomicrons have been shown to protect against endotoxin-induced lethality. LPS-binding protein (LBP) is involved in the inactivation of bacterial toxin by lipoproteins...
  64. ncbi Conversion of chylomicrons into remnants
    M Hultin
    Department of Medical Biochemistry and Biophysics, Umea University, Sweden
    Atherosclerosis 141:S25-9. 1998
    The turnover of chylomicrons in the blood is the sum of several processes. The native chylomicron is synthesized in the intestine out of available substrates...
  65. ncbi Olive oil increases the number of triacylglycerol-rich chylomicron particles compared with other oils: an effect retained when a second standard meal is fed
    Kim G Jackson
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, United Kingdom
    Am J Clin Nutr 76:942-9. 2002
    ..There is a rapid appearance of chylomicrons in the circulation carrying fat ingested with the first meal, with a peak 1 h after the second meal.
  66. ncbi Effect of acute and chronic moderate alcohol consumption on fasted and postprandial lipemia in the rat
    Costantine F Daher
    School of Arts and Sciences, Natural Sciences Division, Biology Department, Lebanese American University, PO Box 36, Byblos, Lebanon
    Food Chem Toxicol 41:1551-9. 2003
    ....
  67. ncbi Postprandial lipaemia in familial combined hyperlipidaemia
    M Castro Cabezas
    Department of Vascular Medicine F02 126, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Biochem Soc Trans 31:1090-3. 2003
    ..Delayed clearance of remnants of VLDL and chylomicrons leads to enhanced interaction of these highly atherogenic particles with the endothelium, and enhanced trans-..
  68. ncbi Triglyceride-rich lipoproteins prime aortic endothelium for an enhanced inflammatory response to tumor necrosis factor-alpha
    Harold J Ting
    Department of Biomedical Engineering, University of California, Davis, Genome and Biomedical Sciences Facility, Davis, CA 95616 5294, USA
    Circ Res 100:381-90. 2007
    ....
  69. ncbi An apolipoprotein(a) peptide delays chylomicron remnant clearance and increases plasma remnant lipoproteins and atherosclerosis in vivo
    Cecilia M Devlin
    Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 25:1704-10. 2005
    ..To investigate the effect of KIV(5-8) on lipoprotein metabolism and atherosclerosis in vivo, we created several independent lines of liver-targeted KIV(5-8) transgenic mice...
  70. ncbi Regulation of plasma triglycerides in insulin resistance and diabetes
    Henry N Ginsberg
    College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Arch Med Res 36:232-40. 2005
    ..in the liver: uptake of fatty acids (FA) released by lipolysis of adipose tissue TG, uptake of TGFA in VLDL and chylomicrons remnants, and hepatic de novo lipogenesis (the synthesis of FA from glucose) are all abnormally increased in ..
  71. ncbi Lipid metabolism and TNF-alpha secretion in response to dietary sterols in human monocyte derived macrophages
    M Napolitano
    Istituto Superiore di Sanit, Viale Regina Elena 299, 00161 Rome, Italy
    Eur J Clin Invest 35:482-90. 2005
    ..These results suggest that changes induced by dietary lipids in human macrophage function are related to an increased propensity of the cells to accumulate lipids during the postprandial phase...
  72. ncbi Postprandial lipemic response and lipoprotein composition in subjects with low or high cholesterol absorption efficiency
    Jyrki J Agren
    Department of Physiology, University of Kuopio, P O B 1627, SF 70211 Kuopio, Finland
    Clin Chim Acta 366:309-15. 2006
    ..The purpose of this study was to investigate the effect of differences in cholesterol absorption efficiency on the postprandial lipemia and lipoprotein composition...
  73. ncbi Triacylglycerol oxidation in pig lipoproteins after a diet rich in oxidized sunflower seed oil
    Jukka Pekka Suomela
    Department of Biochemistry and Food Chemistry, University of Turku, FI 20014 Turku, Finland
    Lipids 40:437-44. 2005
    ..A method based on RP-HPLC and electrospray ionization-MS was used for the analysis of oxidized TAG molecules in chylomicrons and VLDL...
  74. ncbi Metabolism of chylomicron-like emulsions in carriers of the S447X lipoprotein lipase polymorphism
    Katia A Almeida
    Faculty of Pharmaceutical Sciences, , , SP, Brazil
    Clin Chim Acta 335:157-63. 2003
    ..lipase catalyzes the hydrolysis of the triglycerides contained in both very-low-density lipoproteins and chylomicrons for storage in the adipose tissue and muscle of fats of both hepatic and dietary origin...
  75. ncbi A low-protein diet exacerbates postprandial chylomicron concentration in moderately dyslipidaemic subjects in comparison to a lean red meat protein-enriched diet
    J C L Mamo
    School of Public Health, Australian Technology Network Centre for Metabolic Fitness, Curtin University of Technology, Perth, Australia
    Eur J Clin Nutr 59:1142-8. 2005
    ..To investigate whether altering energy intake as red meat protein or carbohydrate modifies chylomicron homeostasis and postprandial lipaemia...
  76. ncbi Meal ingestion provokes entry of lipoproteins containing fat from the previous meal: possible metabolic implications
    K D Renuka R Silva
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, 226, Whiteknights Reading (Berks.) RG6 6AP, UK
    Eur J Nutr 44:377-83. 2005
    ..The results indicate that the degree of TAG "storage" from previous meals might be a function of TAG tolerance and provide a possible site of regulation of the entry of fat into the systemic circulation...
  77. ncbi Intestinal microsomal triglyceride transfer protein in type 2 diabetic and non-diabetic subjects: the relationship to triglyceride-rich postprandial lipoprotein composition
    Catherine Phillips
    Department of Diabetes and Endocrinology, Trinity College Dublin and The Adelaide and Meath Hospital, Diabetes Research Foundation, Clontra, Shankill, Dublin, Ireland
    Atherosclerosis 187:57-64. 2006
    ..Since the MTP promoter region has a sterol response element the effect of statins on intestinal MTP mRNA was analysed...
  78. ncbi Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase
    Martin Merkel
    Department of Internal Medicine IUniversity Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    J Biol Chem 280:21553-60. 2005
    ..In human APOA5 transgenic mice (hAPOA5tr), catabolism of chylomicrons and very low density lipoprotein (VLDL) was accelerated due to a faster plasma hydrolysis of triglycerides by ..
  79. ncbi Real-time assessment of postprandial fat storage in liver and skeletal muscle in health and type 2 diabetes
    B Ravikumar
    School of Clinical Medical Sciences (Diabete)s Medical School, University of Newcastle, UK
    Am J Physiol Endocrinol Metab 288:E789-97. 2005
    ..009). We conclude that the postprandial uptake of fatty acids by liver and skeletal muscle is increased in type 2 diabetes and may underlie the elevated tissue triglyceride stores and consequent insulin resistance...
  80. ncbi Serum sphingomyelin levels are related to the clearance of postprandial remnant-like particles
    Axel Schlitt
    Department of Anatomy and Cell Biology and Scientific Computing Center, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
    J Lipid Res 46:196-200. 2005
    ..apolipoprotein B-containing particles (BLps) than in high density lipoproteins and that BLp levels, including chylomicrons and their remnant particles, are positively related to atherosclerosis...
  81. ncbi Postprandial lipoprotein changes in patients taking antiretroviral therapy for HIV infection
    James H Stein
    University of Wisconsin Medical School, 600 Highland Ave, G7 341 CSC MC 3248 Madison, WI 53792, USA
    Arterioscler Thromb Vasc Biol 25:399-405. 2005
    ..The purpose of this study was to determine whether postprandial lipemia contributes to the dyslipidemia observed in HIV-positive patients taking antiretroviral therapy...
  82. ncbi Dietary diacylglycerol in a typical meal suppresses postprandial increases in serum lipid levels compared with dietary triacylglycerol
    Kazuichi Tomonobu
    Health Care Research Laboratories No 1, Kao Corporation, Tokyo, Japan
    Nutrition 22:128-35. 2006
    ....
  83. ncbi Saturated fat-induced changes in Sf 60-400 particle composition reduces uptake of LDL by HepG2 cells
    Kim G Jackson
    School of Food Biosciences, University of Reading, Reading, Berkshire, United Kingdom
    J Lipid Res 47:393-403. 2006
    ..008). In conclusion, these findings suggest an alternative or additional mechanism whereby acute fat ingestion can influence LDL clearance via competitive apoE-dependent effects of TRL on the LDL receptor...
  84. ncbi Insulin resistance is independently associated with postprandial alterations of triglyceride-rich lipoproteins in type 2 diabetes mellitus
    Giovanni Annuzzi
    Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
    Arterioscler Thromb Vasc Biol 24:2397-402. 2004
    ....
  85. ncbi Positional distribution of decanoic acid: effect on chylomicron and VLDL TAG structures and postprandial lipemia
    Kaisa M Yli-Jokipii
    Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
    Lipids 39:373-81. 2004
    ..05) 30:0 and 38:1 TAG (acyl carbons:double bonds) and fewer 46:5, 54:5, and 54:4 TAG were found in chylomicrons after ingestion of MML than after MLM...
  86. ncbi Impaired postprandial apolipoprotein-B48 metabolism in the obese, insulin-resistant JCR:LA-cp rat: increased atherogenicity for the metabolic syndrome
    D F Vine
    Metabolic and Cardiovascular Diseases Laboratory, Alberta Institute for Human Nutrition, University of Alberta, Edmonton, Alta, Canada
    Atherosclerosis 190:282-90. 2007
    ..Clinically however, the diagnosis of early insulin-resistance remains confounded due to the fact that aberrations in lipid metabolism are not often readily identified using classic indicators of hypercholesterolemia (i.e. LDL)...
  87. ncbi Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states
    Brian R Barrows
    Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9052, USA
    J Clin Endocrinol Metab 91:1446-52. 2006
    ....
  88. ncbi Comparison of ultracentrifugation and nuclear magnetic resonance spectroscopy in the quantification of triglyceride-rich lipoproteins after an oral fat load
    Michael Y Tsai
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
    Clin Chem 50:1201-4. 2004
    ....
  89. ncbi The metabolism of structured triacylglycerols
    Huiling Mu
    BioCentrum DTU, Biochemistry and Nutrition Group, Center for Advanced Food Studies, The Technical University of Denmark, Building 224, DK 2800 Lyngby, Denmark
    Prog Lipid Res 44:430-48. 2005
    ..the following aspects: gastric emptying, specificity of pancreatic lipase, lymphatic transport and clearance of chylomicrons, effects of lipid structure on tissue lipid compositions and the fecal loss of fats...
  90. ncbi Absorption and lipoprotein transport of sphingomyelin
    Ake Nilsson
    Department of Medicine, University of Lund, University Hospital, S 22185 Lund, Sweden
    J Lipid Res 47:154-71. 2006
    ..It is secreted in chylomicrons and VLDL and transferred into HDL via the ABCA1 transporter...
  91. ncbi Effects of increasing doses of simvastatin on fasting lipoprotein subfractions, and the effect of high-dose simvastatin on postprandial chylomicron remnant clearance in normotriglyceridemic patients with premature coronary sclerosis
    J P H van Wijk
    Department of Vascular Medicine, University Medical Center Utrecht, The Netherlands
    Atherosclerosis 178:147-55. 2005
    ..In addition, the lipoprotein subfractions became more cholesterol-poor, as reflected by the increased TG/cholesterol ratio, which potentially makes them less atherogenic...
  92. ncbi Apolipoprotein C-II deficiency syndrome. Clinical features, lipoprotein characterization, lipase activity, and correction of hypertriglyceridemia after apolipoprotein C-II administration in two affected patients
    G Baggio
    J Clin Invest 77:520-7. 1986
    ..sister, 41 and 39 yr of age, respectively) have been shown to have marked elevation of plasma triglycerides and chylomicrons, decreased low density lipoproteins (LDL) and high density lipoproteins (HDL), a type I lipoprotein phenotype, ..
  93. ncbi Effect of insulin resistance on postprandial elevations of remnant lipoprotein concentrations in postmenopausal women
    H S Kim
    Department of Medicine, Stanford University School of Medicine, California 94305, USA
    Am J Clin Nutr 74:592-5. 2001
    ..001). CONCLUSIONS: Postprandial accumulation of RLPs is accentuated in insulin-resistant, postmenopausal women. This may contribute to the increased risk of CAD in these individuals...
  94. ncbi Use of water-miscible retinyl palmitate as markers of chylomicrons gives earlier peak response of plasma retinyl esters compared with oil-soluble retinyl palmitate
    K D Silva
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, Berkshire RG6 6AP, UK
    Br J Nutr 86:427-32. 2001
    ..The RE response to the water-miscible RP showed better concordance with plasma TAG response than that of oil-soluble RP...
  95. ncbi Anomalous lipoproteins in obese Zucker rats
    M Blay
    , , Universitat de Barcelona, Av. Diagonal 645, 08028 Barcelona, Spain
    Diabetes Obes Metab 3:259-70. 2001
    ....
  96. ncbi Comparison of the effects of dietary n-3 and n-6 polyunsaturated fatty acids on very-low-density lipoprotein secretion when delivered to hepatocytes in chylomicron remnants
    X Zheng
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College St, London NW1 0TU, UK
    Biochem J 357:481-7. 2001
    ..Remnants were prepared in vivo from chylomicrons obtained from rats given an oral dose of fish or corn oil and incubated with cultured hepatocytes for up to 16 ..
  97. ncbi Dietary cholesterol is secreted in intestinally derived chylomicrons during several subsequent postprandial phases in healthy humans
    G Beaumier-Gallon
    , Human Nutrition and Lipids, INSERM, Marseille, France
    Am J Clin Nutr 73:870-7. 2001
    ..study aimed to test the hypothesis that dietary cholesterol ingested during a given meal is resecreted into chylomicrons (and plasma) during several subsequent postprandial periods...
  98. ncbi Acute effect of dietary stanyl ester dose on post-absorptive alpha-tocopherol, beta-carotene, retinol and retinyl palmitate concentrations
    H Relas
    Division of Internal Medicine, Department of Medicine, University of Helsinki, PO Box 340, FIN-00029 HYKS, Helsinki, Finland
    Br J Nutr 85:141-7. 2001
    ..and alpha-tocopherol, beta-carotene and retinyl palmitate showed typical postprandial changes in serum, chylomicrons, VLDL and VLDL infranatant (intermediate-density lipoproteins, LDL and HDL) over 24 h after the test meal ..
  99. ncbi The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides
    Corina J A Moen
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    J Lipid Res 48:2182-92. 2007
    ..The increased plasma TG levels in Hyplip2 mice do not result from an enhanced intestinal absorption or increased hepatic VLDL production but are caused by decreased LPL-mediated TG clearance...
  100. ncbi Hypoalbuminemia and proteinuria contribute separately to reduced lipoprotein catabolism in the nephrotic syndrome
    G C Shearer
    Division of Nephrology, Department of Medicine, UC Davis, Davis, CA 95616, USA
    Kidney Int 59:179-89. 2001
    ..Furthermore, clearance of chylomicrons (CM) and very low-density lipoprotein (VLDL) is normal in vivo in NAR despite low LpL levels...
  101. ncbi Postprandial chylomicron formation and fat absorption in multidrug resistance gene 2 P-glycoprotein-deficient mice
    P J Voshol
    Groningen Institute for Drug Studies, Center for Liver, Digestive, and Metabolic Diseases, University Hospital Groningen, Groningen, The Netherlands
    Gastroenterology 118:173-82. 2000
    ..Mdr2((-/-)) mice do not secrete phospholipids and cholesterol into bile, and bile salt secretion is not impaired. Mdr2((+/-)) mice show only impaired (-40%) phospholipid secretion...

Research Grants77

  1. METABOLISM OF INTRAVENOUS LIPID EMULSIONS
    Richard Deckelbaum; Fiscal Year: 2007
    ..These emulsions also serve as models for triglyceride-rich particles (TGRP) such as chylomicrons and VLDL...
  2. ATHEROSCLEROSIS AND PERIPHERAL APOPROTEIN E SYNTHESIS
    David Williams; Fiscal Year: 1999
    ..of high density lipoprotein (HDL), and with remnant particles derived from the intravascular metabolism of chylomicrons and VLDL...
  3. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2003
    ..inhibition of gastric motility is dependent on absorption of lipid by enterocytes, formation and release of chylomicrons and apolipoprotein A-IV (apoA-IV), release of CCK...
  4. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2010
    ..via the thoracic duct, and it also absorbs lipoproteins directly from the small intestinal villi in the form of chylomicrons. Thus, though it is rarely considered, lymphatic vessels are likely to be key participants in cholesterol ..
  5. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2004
    DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
  6. DIETARY CAROTENOIDS - LIPOPROTEIN/CELL INTERACTIONS
    EARL HARRISON; Fiscal Year: 2005
    ..Specific aims are: 1. Mechanisms of intestinal absorption of carotenoids and their incorporation into chylomicrons in CACO-2 cells in culture...
  7. Interactions of Lipoproteins with the Vascular Wall
    JOHN CALVERT RUTLEDGE; Fiscal Year: 2010
    ..TGRL consist of chylomicrons, very low density-lipoproteins (VLDL), and their remnant particles...
  8. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 1999
    DESCRIPTION (Adapted from applicant's abstract): Apolipoprotein (apo) B-containing lipoproteins include the chylomicrons, VLDL and IDL, and LDL and Lp(a)...
  9. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..vein blood, liver, and bile in wild-type and all seven Cyp1 knockout mouse lines, and the role and mechanism of chylomicrons in delivering BaP to target organs; [b] generate liver- and intestinal epithelium-specific Cyp1a1 conditional ..
  10. MPT INHIBITOR IND 50,820 IN FAMILIAL HYPERCHOLESTEROLEM*
    Marina Cuchel; Fiscal Year: 2009
    ..is a protein responsible for transferring lipids onto apolipoprotein B (apo B) in the assembly of intestinal chylomicrons and hepatic very low density lipoprotein (VLDL)...
  11. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..vein blood, liver, and bile in wild-type and all seven Cyp1 knockout mouse lines, and the role and mechanism of chylomicrons in delivering BaP to target organs; [b] generate liver- and intestinal epithelium-specific Cyp1a1 conditional ..
  12. MPT INHIBITOR IND 50,820 IN FAMILIAL HYPERCHOLESTEROLEM*
    Marina Cuchel; Fiscal Year: 2006
    ..is a protein responsible for transferring lipids onto apolipoprotein B (apo B) in the assembly of intestinal chylomicrons and hepatic very low density lipoprotein (VLDL)...
  13. MOLECULAR MECHANISMS OF CHYLOMICRON ASSEMBLY
    M Hussain; Fiscal Year: 2009
    ..We hypothesize that MTP regulates cholesterol ester secretion with chylomicrons by modulating esterification and accretion of cholesterol esters from cytosol to endoplasmic reticulum...
  14. MOLECULAR MECHANISMS OF CHYLOMICRON ASSEMBLY
    M Hussain; Fiscal Year: 2007
    ..We hypothesize that MTP regulates cholesterol ester secretionwith chylomicrons by modulating esterification and accretionof cholesterol esters from cytosol to endoplasmic reticulum...
  15. MOLECULAR MECHANISMS OF CHYLOMICRON ASSEMBLY
    M Mahmood Hussain; Fiscal Year: 2010
    ..We hypothesize that MTP regulates cholesterol ester secretion with chylomicrons by modulating esterification and accretion of cholesterol esters from cytosol to endoplasmic reticulum...
  16. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard Weinberg; Fiscal Year: 2009
    ..by the intestinal enterocytes of mammals during lipid absorption and secreted into lymph on the surface of chylomicrons. Although a broad spectrum of physiologic functions has been proposed for apo A-IV, a preponderance of evidence ..
  17. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard B Weinberg; Fiscal Year: 2010
    ..by the intestinal enterocytes of mammals during lipid absorption and secreted into lymph on the surface of chylomicrons. Although a broad spectrum of physiologic functions has been proposed for apo A-IV, a preponderance of evidence ..
  18. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard Weinberg; Fiscal Year: 2007
    ..by the intestinal enterocytes of mammals during lipid absorption and secreted into lymph on the surface of chylomicrons. Although a broad spectrum of physiologic functions has been proposed for apo A-IV, a preponderance of evidence ..
  19. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2007
    ..Increases in vagal afferent fiber discharge by lipid depend on the formation of chylomicrons and release of apolipoprotein A-IV, release of CCK and stimulation of CCK1 receptors on vagal afferent ..
  20. Irreversible inhibitors of cholesterol esterase
    LORRAINE DECK; Fiscal Year: 2005
    ..that CE functions within the enterocyte to re-esterify cholesterol in the pathway leading to the formation of chylomicrons. It is our hypothesis that inhibition of any of these functions of CE would provide a new approach to the ..
  21. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2009
    ..Increases in vagal afferent fiber discharge by lipid depend on the formation of chylomicrons and release of apolipoprotein A-IV, release of CCK and stimulation of CCK1 receptors on vagal afferent ..