chylomicrons

Summary

Summary: A class of lipoproteins that carry dietary cholesterol and triglycerides from the small intestines to the tissues.

Top Publications

  1. doi Chylomicrons promote intestinal absorption of lipopolysaccharides
    Sarbani Ghoshal
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, KY, USA
    J Lipid Res 50:90-7. 2009
  2. pmc Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons
    Anne P Beigneux
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, and Children s Hospital Oakland Research Institute 94609, USA
    Cell Metab 5:279-91. 2007
  3. pmc Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptake
    Kalyani G Bharadwaj
    Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 285:37976-86. 2010
  4. pmc CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood
    Victor A Drover
    Department of Physiology and Biophysics, State University of New York at Stony Brook, USA
    J Clin Invest 115:1290-7. 2005
  5. ncbi Postprandial dyslipidemia in men with visceral obesity: an effect of reduced LDL receptor expression?
    J C Mamo
    Department of Nutrition, Dietetics and Food Sciences, School of Public Health, Curtin University of Technology, Perth 6845, Australia
    Am J Physiol Endocrinol Metab 281:E626-32. 2001
  6. ncbi Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells
    Alexandrine During
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Lipid Res 48:2283-94. 2007
  7. ncbi Paraoxonase 1 (PON1) is present in postprandial chylomicrons
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 180:55-61. 2005
  8. ncbi A proposed model for the assembly of chylomicrons
    M M Hussain
    Department of Biochemistry, School of Medicine, MCP Hahnemann University, Philadelphia, PA 19129, USA
    Atherosclerosis 148:1-15. 2000
  9. pmc Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 29:956-62. 2009
  10. ncbi Lymphatic chylomicron size is inversely related to biliary phospholipid secretion in mice
    Anniek Werner
    Pediatric Gastroenterology, Department of Pediatrics, Groningen University Institute for Drug Exploration, University Medical Center Groningen, University of Groningen, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 290:G1177-85. 2006

Research Grants

Detail Information

Publications211 found, 100 shown here

  1. doi Chylomicrons promote intestinal absorption of lipopolysaccharides
    Sarbani Ghoshal
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, KY, USA
    J Lipid Res 50:90-7. 2009
    ..The Golgi complex also contains newly formed chylomicrons, the lipoproteins that transport dietary long-chain fat through mesenteric lymph and blood...
  2. pmc Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons
    Anne P Beigneux
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, and Children s Hospital Oakland Research Institute 94609, USA
    Cell Metab 5:279-91. 2007
    The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LpL) along the luminal surface of the capillaries. However, the endothelial cell molecule that facilitates chylomicron processing by LpL has not yet been defined...
  3. pmc Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptake
    Kalyani G Bharadwaj
    Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 285:37976-86. 2010
    ..However, LpL but not CD36 deficiency decreased VLDL-cholesteryl ester uptake. Endogenously labeled mouse chylomicrons were produced by tamoxifen treatment of β-actin-MerCreMer/LpL(flox/flox) mice...
  4. pmc CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood
    Victor A Drover
    Department of Physiology and Biophysics, State University of New York at Stony Brook, USA
    J Clin Invest 115:1290-7. 2005
    ..CD36 deficiency results in hypertriglyceridemia both in the postprandial and fasting states and in humans may constitute a risk factor for diet-induced type 2 diabetes and cardiovascular disease...
  5. ncbi Postprandial dyslipidemia in men with visceral obesity: an effect of reduced LDL receptor expression?
    J C Mamo
    Department of Nutrition, Dietetics and Food Sciences, School of Public Health, Curtin University of Technology, Perth 6845, Australia
    Am J Physiol Endocrinol Metab 281:E626-32. 2001
    ..ml(-1). h; RP: 3,120 +/- 511 vs. 1,308 +/- 177 U. ml(-1). h, respectively). A delay in the conversion of chylomicrons to remnants probably contributed to postprandial dyslipidemia in viscerally obese subjects...
  6. ncbi Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells
    Alexandrine During
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Lipid Res 48:2283-94. 2007
    ..efflux into basolateral medium (BM) increased linearly with time, ROL in the nonlipoprotein fraction and REs in chylomicrons (CMs). In contrast to carotenoids, ROL uptake was proportional to ROL concentration (0.5-110 microM)...
  7. ncbi Paraoxonase 1 (PON1) is present in postprandial chylomicrons
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 180:55-61. 2005
    ..As diet affects serum PON1 activity, we questioned whether PON1 is also carried by postprandial chylomicrons. Chylomicrons were isolated by ultracentrifugation from plasma of 10 healthy men, 3h after the consumption of a ..
  8. ncbi A proposed model for the assembly of chylomicrons
    M M Hussain
    Department of Biochemistry, School of Medicine, MCP Hahnemann University, Philadelphia, PA 19129, USA
    Atherosclerosis 148:1-15. 2000
    The intestine synthesizes very low density lipoproteins (VLDL) and chylomicrons (CM) to transport fat and fat-soluble vitamins into the blood...
  9. pmc Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 29:956-62. 2009
    GPIHBP1 is an endothelial cell protein that binds lipoprotein lipase (LPL) and chylomicrons. Because GPIHBP1 deficiency causes chylomicronemia in mice, we sought to determine whether some cases of chylomicronemia in humans could be ..
  10. ncbi Lymphatic chylomicron size is inversely related to biliary phospholipid secretion in mice
    Anniek Werner
    Pediatric Gastroenterology, Department of Pediatrics, Groningen University Institute for Drug Exploration, University Medical Center Groningen, University of Groningen, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 290:G1177-85. 2006
    ..Altered CM size may have physiological consequences for postprandial CM processing...
  11. ncbi Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency
    R L Hamilton
    Cardiovascular Research Institute, University of California, San Francisco 94143 0452, USA
    J Lipid Res 39:1543-57. 1998
    ..for packaging large quantities of neutral lipids into apolipoprotein (apo) B-containing lipoproteins (chylomicrons or VLDL) are incompletely understood...
  12. ncbi Overexpression of apolipoprotein A-IV enhances lipid secretion in IPEC-1 cells by increasing chylomicron size
    Song Lu
    Children s Foundation Research Center at Le Bonheur Children s Medical Center and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
    J Biol Chem 281:3473-83. 2006
    ..The EQQQ-rich region may play an inhibitory or modulatory role in chylomicron packaging in humans...
  13. doi The biogenesis of chylomicrons
    Charles M Mansbach
    The University of Tennessee Health Science Center and the Veterans Administration Medical Center, Memphis, TN 38163, USA
    Annu Rev Physiol 72:315-33. 2010
    ....
  14. pmc Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects
    Remco Franssen
    Department of Vascular Medicine, Academic Medical Center Amsterdam, The Netherlands
    Circ Cardiovasc Genet 3:169-78. 2010
    ....
  15. pmc Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia
    Gunilla Olivecrona
    Department of Medical Biosciences Physiological Chemistry, Umea University, Umea, Sweden
    J Lipid Res 51:1535-45. 2010
    ..Thus, the conserved cysteines in the Ly6 domain are crucial for GPIHBP1 function...
  16. ncbi CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine
    Fatiha Nassir
    Department of Medicine, Division of Nutritional Science, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:19493-501. 2007
    ..The findings support the role of CD36 in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, whereas CD36-independent mechanisms predominate in distal segments...
  17. ncbi Development and physiological regulation of intestinal lipid absorption. I. Development of intestinal lipid absorption: cellular events in chylomicron assembly and secretion
    Dennis D Black
    Children s Foundation Research Center of Memphis, Le Bonheur Children s Medical Center, 50 N Dunlap Street, Memphis, TN 38103, USA
    Am J Physiol Gastrointest Liver Physiol 293:G519-24. 2007
    The newborn mammal must efficiently absorb dietary fat, predominantly as triacylglycerol, and produce chylomicrons to deliver this lipid to peripheral tissues...
  18. ncbi COPII proteins are required for Golgi fusion but not for endoplasmic reticulum budding of the pre-chylomicron transport vesicle
    Shadab A Siddiqi
    Division of Gastroenterology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Cell Sci 116:415-27. 2003
    ..Together, these findings suggest that COPII proteins may not be required for the exit of membrane-bound chylomicrons from the ER but that they or other proteins may be necessary for PCTV fusion with the Golgi.
  19. ncbi The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins
    Peter J O'Brien
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Clin Chem 51:351-9. 2005
    ..Despite these compelling molecular biology data, relatively little is known about ApoA5 protein in human serum...
  20. ncbi Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons
    Emile Levy
    Department of Nutrition, Hôpital Sainte Justine and University of Montreal, Montreal, Quebec H3T 1C5, Canada
    J Biol Chem 277:16470-7. 2002
    ..The occurrence of membrane-associated apoB in the Golgi, coupled with its interaction with active MTP, suggests an important role for the Golgi in the biogenesis of apoB-containing lipoproteins...
  21. ncbi Development and physiological regulation of intestinal lipid absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons
    Charles M Mansbach
    Division of Gastroenterology, The Univ of Tennessee Health Science Center, 920 Madison Ave, Suite 240, Memphis, TN 38163, USA
    Am J Physiol Gastrointest Liver Physiol 293:G645-50. 2007
    ..aspects of this process from the mechanisms of fatty acid uptake to the control of triacylglycerol export in chylomicrons. Recent advances have included the identification of a number of fatty acid transporters, the discovery of ..
  22. ncbi Scavenger receptor BI plays a role in facilitating chylomicron metabolism
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, 2300 RA Leiden, The Netherlands
    J Biol Chem 279:18401-6. 2004
    ....
  23. ncbi Atorvastatin improves postprandial lipoprotein metabolism in normolipidemlic subjects
    K G Parhofer
    Department of Internal Medicine II, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Clin Endocrinol Metab 85:4224-30. 2000
    ....
  24. pmc Cholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulation
    Tam M Nguyen
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Lipid Res 53:95-104. 2012
    ..would increase cholesterol absorption efficiency by providing cholesteryl ester (CE) for incorporation into chylomicrons. The assumption was that absorption would be proportional to Acat2 gene dosage...
  25. pmc Postprandial lipoprotein metabolism: VLDL vs chylomicrons
    Katsuyuki Nakajima
    School of Health Sciences, Faculty of Medicine, Gunma University, Maebashi, Gunma, Japan
    Clin Chim Acta 412:1306-18. 2011
    Since Zilversmit first proposed postprandial lipemia as the most common risk of cardiovascular disease, chylomicrons (CM) and CM remnants have been thought to be the major lipoproteins which are increased in the postprandial ..
  26. ncbi Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both
    S Ishibashi
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    J Biol Chem 271:22422-7. 1996
    ..in the plasma of the LDLR(-/-) mice was distributed in larger subfractions of triglyceride-rich lipoproteins, chylomicrons through very low density lipoprotein-C...
  27. ncbi Acceleration of uptake of LDL but not chylomicrons or chylomicron remnants by cells that secrete apoE and hepatic lipase
    S Y Choi
    Research Institute, Palo Alto Medical Foundation, CA 94301
    J Lipid Res 35:848-59. 1994
    ..125I-labeled LDL, chylomicron remnants, or chylomicrons were added to media at concentrations near their Kd...
  28. pmc The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium
    Alexander Jaschke
    Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam Rehbruecke, D 14558 Nuthetal, Germany
    Hum Mol Genet 21:3128-42. 2012
    ..Here, we describe the essential role of ARFRP1 and its interaction with Rab2 in the assembly and lipidation of chylomicrons in the intestinal epithelium...
  29. pmc The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Mol Endocrinol 22:2496-504. 2008
    ..GPIHBP1 binds lipoprotein lipase and chylomicrons and is expressed along the luminal surface of microvascular endothelial cells...
  30. ncbi The unsaponifiable fraction of virgin olive oil in chylomicrons from men improves the balance between vasoprotective and prothrombotic factors released by endothelial cells
    Javier S Perona
    Instituto de la Grasa CSIC, 41012 Sevilla, Spain
    J Nutr 134:3284-9. 2004
    ....
  31. ncbi Chylomicrons in disease-future challenges Invited keynote address
    Trevor G Redgrave
    Physiology, School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Nedlands, Western Australia 6009, Australia
    Atheroscler Suppl 9:3-6. 2008
    ..Acceptance of the premise that chylomicrons play a key role in atherogenesis brings new understanding to the mechanisms underlying empirical risk-reduction ..
  32. pmc Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Biochim Biophys Acta 1771:1464-8. 2007
    ..A hallmark of GPIHBP1 is the ability to bind lipoprotein lipase, chylomicrons, and apolipoprotein (apo-) AV...
  33. ncbi Uptake of lipophilic drugs by plasma derived isolated chylomicrons: linear correlation with intestinal lymphatic bioavailability
    Pavel Gershkovich
    Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, P O Box 12065, 91120 Jerusalem, Israel
    Eur J Pharm Sci 26:394-404. 2005
    Association of a drug with chylomicrons in the enterocyte is an essential step in the lymphatic absorption pathway...
  34. ncbi Incorporation of carotenoids from paprika oleoresin into human chylomicrons
    Antonio Pérez-Gálvez
    Institute for Physiological Chemistry I, Henrich Heine University Düsseldorf, Dusseldorf, Germany
    Br J Nutr 89:787-93. 2003
    ..However, oleoresin is a suitable source for the provitamin A carotenoids beta-carotene and beta-cryptoxanthin and the macular pigment zeaxanthin...
  35. ncbi Are we ready for a prospective study to investigate the role of chylomicrons in cardiovascular disease?
    Jeffrey S Cohn
    Nutrition and Metabolism Group, Heart Research Institute, 114 Pyrmont Bridge Road, Camperdown, NSW 2050, Australia
    Atheroscler Suppl 9:15-8. 2008
    Intestinal chylomicrons and their remnants are believed to contribute both directly and indirectly to the onset and development of atherosclerosis...
  36. ncbi Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, 2300 RA Leiden, The Netherlands
    J Lipid Res 46:1172-81. 2005
    ....
  37. doi Variable phenotypic expression of chylomicron retention disease in a kindred carrying a mutation of the Sara2 gene
    Angelo B Cefalù
    Departmet of Clinical Medicine and Emerging Diseases, University of Palermo, I 90127 Palermo, Italy
    Metabolism 59:463-7. 2010
    ..More studies are needed to understand the reasons of the phenotypic variability of the same molecular defect in the same family...
  38. pmc Homozygous missense mutation (G56R) in glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPI-HBP1) in two siblings with fasting chylomicronemia (MIM 144650)
    Jian Wang
    Schulich School of Medicine and Dentistry, University of Western Ontario and Vascular Biology Research Group, Robarts Research Institute, London, Ontario, N6A 5K8, Canada
    Lipids Health Dis 6:23. 2007
    ....
  39. ncbi Vitamin A intake affects the contribution of chylomicrons vs. retinol-binding protein to milk vitamin A in lactating rats
    M H Green
    Nutrition Department, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 131:1279-82. 2001
    To investigate the influence of vitamin A intake on the contribution of chylomicrons vs...
  40. ncbi Postprandial chylomicrons: potent vehicles for transporting cholesterol from endogenous LDL+HDL and cell membranes to the liver via LCAT and CETP
    Byung Hong Chung
    Atherosclerosis Research Unit, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Lipid Res 45:1242-55. 2004
    We examined whether postprandial (PP) chylomicrons (CMs) can serve as vehicles for transporting cholesterol from endogenous cholesterol-rich lipoprotein (LDL+HDL) fractions and cell membranes to the liver via lecithin:cholesterol ..
  41. pmc Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor
    J Herz
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Proc Natl Acad Sci U S A 92:4611-5. 1995
    ..The rate of chylomicron remnant removal by the liver was normal up to 30 min after intravenous injection of chylomicrons into LDLR (-/-) mice and was unaffected by receptor-associated protein (RAP), a potent inhibitor of ligand ..
  42. ncbi Size distributions of chylomicrons from human lymph from dynamic light scattering measurements
    H Ruf
    Max Planck Institut fur Biophysik, Frankfurt a M, Germany
    Eur Biophys J 28:1-11. 1999
    b>Chylomicrons, the vehicles for the transport of exogeneous triglycerides and cholesterol in the lymph and the blood, were characterized by their size from dynamic light scattering measurements...
  43. ncbi Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons
    Anita C E Vreugdenhil
    Nutrition and Toxicology Research Institute Maastricht, Department of General Surgery, Maastricht University, Maastricht, The Netherlands
    J Immunol 170:1399-405. 2003
    b>Chylomicrons have been shown to protect against endotoxin-induced lethality. LPS-binding protein (LBP) is involved in the inactivation of bacterial toxin by lipoproteins...
  44. doi Metabolism of very-low-density lipoprotein and chylomicrons by streptozotocin-induced diabetic rat heart: effects of diabetes and lipoprotein preference
    You Guo Niu
    Department of Clinical Aerospace Medicine, The Fourth Military Medical University, Xi an, China
    Am J Physiol Endocrinol Metab 295:E1106-16. 2008
    Very-low-density lipoprotein (VLDL) and chylomicrons (CM) are major sources of fatty acid supply to the heart, but little is known about their metabolism in diabetic myocardium...
  45. ncbi Olive oil increases the number of triacylglycerol-rich chylomicron particles compared with other oils: an effect retained when a second standard meal is fed
    Kim G Jackson
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, United Kingdom
    Am J Clin Nutr 76:942-9. 2002
    ..There is a rapid appearance of chylomicrons in the circulation carrying fat ingested with the first meal, with a peak 1 h after the second meal.
  46. pmc Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT)
    Sheila M O'Byrne
    Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 280:35647-57. 2005
    ..Lrat-/- mice absorb dietary retinol primarily as free retinol in chylomicrons; however, retinyl esters are also present within the chylomicron fraction obtained from Lrat-/- mice...
  47. ncbi Carboxyl ester lipase overexpression in rat hepatoma cells and CEL deficiency in mice have no impact on hepatic uptake or metabolism of chylomicron-retinyl ester
    A M Van Bennekum
    Department of Biochemistry, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19129, USA
    Biochemistry 38:4150-6. 1999
    ....
  48. ncbi Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation
    F Karpe
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK
    Biochem Soc Trans 35:472-6. 2007
    The triacylglycerol content of chylomicrons and VLDL (very-low-density lipoprotein) compete for the same lipolytic pathway in the capillary beds...
  49. ncbi Plasma clearance and liver uptake of chylomicron remnants generated by hepatic lipase lipolysis: evidence for a lactoferrin-sensitive and apolipoprotein E-independent pathway
    S E Crawford
    Department of Pathology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Lipid Res 40:797-805. 1999
    b>Chylomicrons labeled with [3H]cholesterol and [14C]triglyceride fatty acids were lipolyzed by hepatic lipase (HL) in vitro and then injected intravenously into normal mice fed low- or high-fat diets, and into apolipoprotein (apo) E-..
  50. ncbi Intestinal lipoprotein assembly
    M Mahmood Hussain
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Curr Opin Lipidol 16:281-5. 2005
    ..In this review we propose a nomenclature for these lipoproteins and have summarized recent data about their intracellular assembly and factors that modulate their secretion...
  51. ncbi Anderson or chylomicron retention disease: molecular impact of five mutations in the SAR1B gene on the structure and the functionality of Sar1b protein
    Mathilde Charcosset
    UF Lipides Dyslipidémies, Laboratoire de Biochimie, CBE, 59 Boulevard Pinel, Bron Cedex, France
    Mol Genet Metab 93:74-84. 2008
    ..A determination of the specific mutation in Anderson disease or CMRD is required to ensure diagnosis and allow prompt therapeutic intervention in these children...
  52. ncbi Postprandial lipoproteins and atherosclerosis
    K C Yu
    Research Institute, Ames Building, Palo Alto Medical Foundation 795 El Camino Real, Palo Alto, CA 94301, USA
    Front Biosci 6:D332-54. 2001
    ..state, dietary lipid is transported from the intestine to peripheral tissues by plasma lipoproteins called chylomicrons. In the capillary beds of peripheral tissues, chylomicron triglycerides are lipolyzed by the enzyme, ..
  53. pmc Normotriglyceridemic abetalipoproteinemia. absence of the B-100 apolipoprotein
    M J Malloy
    J Clin Invest 67:1441-50. 1981
    ..and very low density lipoproteins are absent, but in which triglycerides are absorbed from the intestine and chylomicrons are present in plasma...
  54. ncbi Fibrinogen in rat gastrointestinal lymph before, during and after intraduodenal administration of emulsified triglyceride: fibrinogen bound to chylomicrons in gastrointestinal lymph is functional
    Ashley P DeAnglis
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Thromb Res 105:419-32. 2002
    ..Levels of the same analytes changed little, if at all, in control animals. As assessed using immunoblotting, chylomicrons in gastrointestinal lymph are coated with fibrinogen...
  55. ncbi Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia
    J R Wetterau
    Department of Metabolic Diseases, Bristol Myers Squibb, Princeton, NJ 08543 4000
    Science 258:999-1001. 1992
    ..that is characterized by a defect in the assembly or secretion of plasma very low density lipoproteins and chylomicrons. The microsomal triglyceride transfer protein (MTP), which is located in the lumen of microsomes isolated from ..
  56. doi Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage
    Toralph Ruge
    Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford OX3 7LJ, United Kingdom
    J Clin Endocrinol Metab 94:1781-8. 2009
    ..Adipose tissue sequesters dietary fat and thus protects other tissues from excess fat exposure, especially after meals...
  57. ncbi The diurnal rhythms of cholesterol metabolism and plasma clearance of model chylomicrons: comparison of normal and genetically hypercholesterolemic rats (RICO)
    B C Mortimer
    Department of Physiology, University of Western Australia, Nedlands, Australia
    Comp Biochem Physiol A Mol Integr Physiol 120:671-80. 1998
    Previous studies showed a slower clearance of cholesterol-labeled lymph chylomicrons in genetically hypercholesterolemic rats (RICO) compared with normocholesterolemic rats...
  58. ncbi Decreased hepatic expression of the low-density lipoprotein (LDL) receptor and LDL receptor-related protein in aging rats is associated with delayed clearance of chylomicrons from the circulation
    P A Field
    Metabolic Research Laboratory, Oxford Lipid Metabolism Group, University of Oxford, UK
    Metabolism 49:492-8. 2000
    ..intravenously injected bolus of 14C-labeled cholesterol ester (CE) and 3H-labeled triacylglycerol (TAG) lymph chylomicrons was markedly delayed in the old rats (P < .05)...
  59. ncbi Vegetable-borne lutein, lycopene, and beta-carotene compete for incorporation into chylomicrons, with no adverse effect on the medium-term (3-wk) plasma status of carotenoids in humans
    Viviane Tyssandier
    Unite Maladies Metaboliques et Micronutriments, INRA, Clermont Ferrand Theix, Saint Genes Champanelle, France
    Am J Clin Nutr 75:526-34. 2002
    ..The results of epidemiologic studies have consistently shown associations between dietary intake or plasma carotenoid status and incidence of cancers and cardiovascular and eye diseases...
  60. pmc Mobilisation of enterocyte fat stores by oral glucose in humans
    M D Robertson
    Metabolic Research Group, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, UK
    Gut 52:834-9. 2003
    ..The aim of this study was to investigate the location and release of lipid from within the gastrointestinal tract...
  61. ncbi Effect of dietary fatty acids on the postprandial fatty acid composition of triacylglycerol-rich lipoproteins in healthy male subjects
    A Bysted
    BioCentrum DTU, Section of Biochemistry and Nutrition, Center of Advanced Food Studies, The Technical University of Denmark, Lyngby, Denmark
    Eur J Clin Nutr 59:24-34. 2005
    The aim of the present study was to investigate the effect of trans-18:1 isomers compared to other fatty acids, especially saturates, on the postprandial fatty acid composition of triacylglycerols (TAG) in chylomicrons and VLDL.
  62. ncbi Butter differs from olive oil and sunflower oil in its effects on postprandial lipemia and triacylglycerol-rich lipoproteins after single mixed meals in healthy young men
    Nadia Mekki
    Unité 476 Institut National de la Santé et de la Recherche Médicale, Human Nutrition and Lipids, National Institute of Health and Medical Research, Universite de la Mediterranee, 13009 Marseille, France
    J Nutr 132:3642-9. 2002
    ..The butter meal induced a lower postprandial rise of triacylglycerols in serum and chylomicrons (incremental AUC, mmol.h/L: 0.72) than the two unsaturated oils (olive oil: 1.6, sunflower oil: 1...
  63. ncbi The incorporation and metabolism of amyloid-beta into chylomicron-like lipid emulsions
    Anthony P James
    Department of Nutrition, Dietetics and Food Science, Curtin University of Technology, Perth, Australia
    J Alzheimers Dis 5:179-88. 2003
    ..Chylomicron-like lipid emulsions, resembling chylomicrons in composition, size and metabolism were prepared in the presence of [125I]Abeta1-40...
  64. ncbi Chylomicron and VLDL TAG structures and postprandial lipid response induced by lard and modified lard
    Kaisa M Yli-Jokipii
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    Lipids 38:693-703. 2003
    ..were less TAG with palmitic acid in the sn-2 position and more TAG with oleic acid in the sn-2 position in chylomicrons than in fat ingested. From 1...
  65. ncbi The intracellular transport of chylomicrons requires the small GTPase, Sar1b
    Carol C Shoulders
    Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Curr Opin Lipidol 15:191-7. 2004
    ..This review focuses on the assembly and structural evolution of COPII (coat protein) transport carriers that are essential for the transport of chylomicrons from the endoplasmic reticulum to the Golgi apparatus.
  66. ncbi Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders
    Bethan Jones
    Genomic and Molecular Medicine Group, MRC Clinical Sciences Centre, Imperial College, London, England, UK
    Nat Genet 34:29-31. 2003
    ..Our data suggest that chylomicrons, which vastly exceed the size of typical COPII vesicles, are selectively recruited by the COPII machinery for ..
  67. ncbi Glibenclamide improves postprandial hypertriglyceridaemia in type 2 diabetic patients by reducing chylomicrons but not the very low-density lipoprotein subfraction levels
    I Skrapari
    1st Department Propaedeutic Medicine, Athens University Medical School, Laiko General Hospital, Athens, Greece
    Diabet Med 18:781-5. 2001
    ..Total triglyceride levels in plasma, in chylomicrons (CM), in CM-deficient plasma, in very low-density lipoprotein (VLDL) subfractions (VLDL-1, VLDL-2) and in ..
  68. pmc Vesicle-associated membrane protein 7 is expressed in intestinal ER
    Shadab A Siddiqi
    Division of Gastroenterology, The University of Tennessee Health Science Center, Memphis, TN 38163 USA
    J Cell Sci 119:943-50. 2006
    ..We conclude that VAMP7 is enriched in intestinal ER and that it plays a functional role in the delivery of triacylglycerol from the ER to the Golgi...
  69. ncbi Sitosterol and cholesterol in chylomicrons of type 2 diabetic and non-diabetic subjects: the relationship with ATP binding cassette proteins G5 and G8 and Niemann-Pick C1-like 1 mRNA
    S E Lally
    Diabetologia 50:217-9. 2007
  70. ncbi Effects of prior moderate exercise on exogenous and endogenous lipid metabolism and plasma factor VII activity
    J M Gill
    Human Muscle Metabolism Research Group, Loughborough University, Loughborough, LE113TU, UK
    Clin Sci (Lond) 100:517-27. 2001
    ....
  71. ncbi Retinyl ester secretion by intestinal cells: a specific and regulated process dependent on assembly and secretion of chylomicrons
    N Nayak
    Department of Biochemistry, School of Medicine, MCP Hahnemann University, Philadelphia, PA 19129, USA
    J Lipid Res 42:272-80. 2001
    ..We propose that RE are added to CM during final stages of lipoprotein assembly and may serve as signposts for these steps...
  72. ncbi Effect of oxidized lipids in the diet on oxidized lipid levels in postprandial serum chylomicrons of diabetic patients
    I Staprans
    Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Diabetes Care 22:300-6. 1999
    ..To determine whether humans with type 2 diabetes have increased levels of oxidized fatty acids in their serum chylomicron fraction after the ingestion of dietary oxidized fatty acids...
  73. ncbi Signposts in the assembly of chylomicrons
    M M Hussain
    Departments of Anatomy and Cell Biology, and Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Front Biosci 6:D320-31. 2001
    Intestinal cells synthesize and secrete chylomicrons in the postprandial state. Synthesis of these particles is defective in abetalipoproteinemia and chylomicron retention disease...
  74. doi Three-dimensional immunofluorescent double labelling using polyclonal antibodies derived from the same species: enterocytic colocalization of chylomicrons with Golgi apparatus
    R Takechi
    Australian Technology Centre for Metabolic Fitness, School of Public Health, Division of Health Sciences, Curtin University of Technology, GPO Box U1987, Perth, WA, 6845, Australia
    Histochem Cell Biol 129:779-84. 2008
    ..Colocalization of apo B and Golgi apparatus (75.2 +/- 8.5%) is consistent with the purported mode of secretion of these macromolecules...
  75. ncbi The mechanism of the formation and secretion of chylomicrons
    Tammy Kindel
    University of Cincinnati College of Medicine, United States
    Atheroscler Suppl 11:11-6. 2010
    ..luminal digestion, followed by cellular uptake and processing, and subsequent extracellular transport of chylomicrons. We discuss the importance of acid and pancreatic lipase in lipid digestion...
  76. doi Postprandial chylomicrons and adipose tissue lipoprotein lipase are altered in type 2 diabetes independently of obesity and whole-body insulin resistance
    Giovanni Annuzzi
    Department of Clinical and Experimental Medicine, Federico II University, Via Pansini 5, 80131 Naples, Italy
    Nutr Metab Cardiovasc Dis 18:531-8. 2008
    ..The aim of this study is to differentiate the effects of whole-body insulin resistance, obesity, and type 2 diabetes on postprandial dyslipidaemia and lipoprotein lipase (LPL) in adipose tissue...
  77. pmc GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons
    Stephen G Young
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Curr Opin Lipidol 18:389-96. 2007
    To summarize recent data indicating that glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) plays a key role in the lipolytic processing of chylomicrons.
  78. ncbi Pluronic L81 enhances triacylglycerol accumulation in the cytosol and inhibits chylomicron secretion
    Sumbul Fatma
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    J Lipid Res 47:2422-32. 2006
    ..14C]PL81 inhibited the secretion of chylomicrons (CMs), lipoproteins essential for fat absorption, by differentiated Caco-2 cells similar to PL81...
  79. ncbi The elevation of ingested lipids within plasma chylomicrons is prolonged in men compared with women
    Nicolas D Knuth
    Substrate Metabolism Laboratory, Division of Kinesiology, University of Michigan, Ann Arbor, MI 48109 2214, USA
    J Nutr 136:1498-503. 2006
    ..The purpose of this study was to measure the recovery of ingested fat in plasma fractions of chylomicrons (CHYLO), VLDL, and plasma fatty acids, as well as in expired breath (i.e., oxidation) in men and women...
  80. pmc Chylomicrons promote intestinal absorption and systemic dissemination of dietary antigen (ovalbumin) in mice
    Yuehui Wang
    Department of Internal Medicine, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 4:e8442. 2009
    ..contain long-chain triglycerides (LCT), which stimulate mesenteric lymph flux and postprandial transport of chylomicrons through mesenteric lymph nodes (MLN) and blood...
  81. pmc The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 283:29554-62. 2008
    ..g. chylomicrons)...
  82. ncbi Effects of palm oil and transesterified palm oil on chylomicron and VLDL triacylglycerol structures and postprandial lipid response
    K Yli-Jokipii
    Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014 Turku, Finland
    J Lipid Res 42:1618-25. 2001
    The effects of positional distribution of triacylglycerol (TAG) fatty acids to TAG structures in chylomicrons and VLDL, and to postprandial lipemia, were studied in 10 healthy premenopausal women using a 6-h oral fat load test and a ..
  83. doi Chylomicron retention disease: a long term study of two cohorts
    Noel Peretti
    Department of Nutrition, CHU Sainte Justine, Universite de Montreal, GI Nutrition Unit, 3175 Ste Catherine Road, Montreal, Que, Canada
    Mol Genet Metab 97:136-42. 2009
    ..This study provides new insights on the phenotypic expression of CRD over time and emphasizes the need to screen the lipid profile of infants with chronic diarrhea and failure to thrive...
  84. ncbi Conversion of chylomicrons into remnants
    M Hultin
    Department of Medical Biochemistry and Biophysics, Umea University, Sweden
    Atherosclerosis 141:S25-9. 1998
    The turnover of chylomicrons in the blood is the sum of several processes. The native chylomicron is synthesized in the intestine out of available substrates...
  85. ncbi The effect of exercise on postprandial lipidemia in type 2 diabetic patients
    L W L Tobin
    Department of Rheumatology, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400, Copenhagen NV, Denmark
    Eur J Appl Physiol 102:361-70. 2008
    ..patients, after a high-fat meal exercise reduces the plasma concentrations of triglyceride contained in both chylomicrons and VLDL as well as insulin secretion...
  86. ncbi Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase
    Martin Merkel
    Department of Internal Medicine IUniversity Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    J Biol Chem 280:21553-60. 2005
    ..In human APOA5 transgenic mice (hAPOA5tr), catabolism of chylomicrons and very low density lipoprotein (VLDL) was accelerated due to a faster plasma hydrolysis of triglycerides by ..
  87. ncbi Real-time assessment of postprandial fat storage in liver and skeletal muscle in health and type 2 diabetes
    B Ravikumar
    School of Clinical Medical Sciences Diabete s Medical School, University of Newcastle, UK
    Am J Physiol Endocrinol Metab 288:E789-97. 2005
    ..009). We conclude that the postprandial uptake of fatty acids by liver and skeletal muscle is increased in type 2 diabetes and may underlie the elevated tissue triglyceride stores and consequent insulin resistance...
  88. ncbi Positional distribution of decanoic acid: effect on chylomicron and VLDL TAG structures and postprandial lipemia
    Kaisa M Yli-Jokipii
    Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
    Lipids 39:373-81. 2004
    ..05) 30:0 and 38:1 TAG (acyl carbons:double bonds) and fewer 46:5, 54:5, and 54:4 TAG were found in chylomicrons after ingestion of MML than after MLM...
  89. ncbi Effects of increasing doses of simvastatin on fasting lipoprotein subfractions, and the effect of high-dose simvastatin on postprandial chylomicron remnant clearance in normotriglyceridemic patients with premature coronary sclerosis
    J P H van Wijk
    Department of Vascular Medicine, University Medical Center Utrecht, The Netherlands
    Atherosclerosis 178:147-55. 2005
    ..In addition, the lipoprotein subfractions became more cholesterol-poor, as reflected by the increased TG/cholesterol ratio, which potentially makes them less atherogenic...
  90. ncbi Postprandial lipoprotein changes in patients taking antiretroviral therapy for HIV infection
    James H Stein
    University of Wisconsin Medical School, 600 Highland Ave, G7 341 CSC MC 3248 Madison, WI 53792, USA
    Arterioscler Thromb Vasc Biol 25:399-405. 2005
    ..The purpose of this study was to determine whether postprandial lipemia contributes to the dyslipidemia observed in HIV-positive patients taking antiretroviral therapy...
  91. ncbi Insulin resistance is independently associated with postprandial alterations of triglyceride-rich lipoproteins in type 2 diabetes mellitus
    Giovanni Annuzzi
    Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
    Arterioscler Thromb Vasc Biol 24:2397-402. 2004
    ....
  92. ncbi Meal ingestion provokes entry of lipoproteins containing fat from the previous meal: possible metabolic implications
    K D Renuka R Silva
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, 226, Whiteknights Reading Berks RG6 6AP, UK
    Eur J Nutr 44:377-83. 2005
    ..After consuming 2 meals an early plasma TAG peak has been observed after the second meal, the origin of which is unclear...
  93. doi Delayed metabolism of postprandial triglyceride-rich lipoproteins in subjects with echolucent carotid plaques
    Ann Trude With Notø
    Center for Atherothrombotic Research in Tromsø, Institute of Clinical Medicine, University of Tromsø, 9037, Tromsø, Norway
    Lipids 43:353-60. 2008
    ....
  94. ncbi Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states
    Brian R Barrows
    Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9052, USA
    J Clin Endocrinol Metab 91:1446-52. 2006
    ..The liver's regulation of fatty acids (FAs) postprandially may contribute to risk of metabolic diseases...
  95. ncbi Serum sphingomyelin levels are related to the clearance of postprandial remnant-like particles
    Axel Schlitt
    Department of Anatomy and Cell Biology and Scientific Computing Center, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
    J Lipid Res 46:196-200. 2005
    ..apolipoprotein B-containing particles (BLps) than in high density lipoproteins and that BLp levels, including chylomicrons and their remnant particles, are positively related to atherosclerosis...
  96. ncbi Triacylglycerol oxidation in pig lipoproteins after a diet rich in oxidized sunflower seed oil
    Jukka Pekka Suomela
    Department of Biochemistry and Food Chemistry, University of Turku, FI 20014 Turku, Finland
    Lipids 40:437-44. 2005
    ..A method based on RP-HPLC and electrospray ionization-MS was used for the analysis of oxidized TAG molecules in chylomicrons and VLDL...
  97. ncbi Postprandial lipemic response and lipoprotein composition in subjects with low or high cholesterol absorption efficiency
    Jyrki J Agren
    Department of Physiology, University of Kuopio, P O B 1627, SF 70211 Kuopio, Finland
    Clin Chim Acta 366:309-15. 2006
    ..The purpose of this study was to investigate the effect of differences in cholesterol absorption efficiency on the postprandial lipemia and lipoprotein composition...
  98. ncbi Effect of a high-fat meal on absorption and disposition of lipophilic compounds: the importance of degree of association with triglyceride-rich lipoproteins
    Pavel Gershkovich
    Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel
    Eur J Pharm Sci 32:24-32. 2007
    ..This concept was assessed in rats using two model compounds, DDT with high affinity to chylomicrons and diazepam which does not bind to chylomicrons...
  99. ncbi Saturated fat-induced changes in Sf 60-400 particle composition reduces uptake of LDL by HepG2 cells
    Kim G Jackson
    School of Food Biosciences, University of Reading, Reading, Berkshire, United Kingdom
    J Lipid Res 47:393-403. 2006
    ..008). In conclusion, these findings suggest an alternative or additional mechanism whereby acute fat ingestion can influence LDL clearance via competitive apoE-dependent effects of TRL on the LDL receptor...
  100. ncbi Impaired postprandial apolipoprotein-B48 metabolism in the obese, insulin-resistant JCR:LA-cp rat: increased atherogenicity for the metabolic syndrome
    D F Vine
    Metabolic and Cardiovascular Diseases Laboratory, Alberta Institute for Human Nutrition, University of Alberta, Edmonton, Alta, Canada
    Atherosclerosis 190:282-90. 2007
    ..Clinically however, the diagnosis of early insulin-resistance remains confounded due to the fact that aberrations in lipid metabolism are not often readily identified using classic indicators of hypercholesterolemia (i.e. LDL)...
  101. ncbi The metabolism of structured triacylglycerols
    Huiling Mu
    BioCentrum DTU, Biochemistry and Nutrition Group, Center for Advanced Food Studies, The Technical University of Denmark, Building 224, DK 2800 Lyngby, Denmark
    Prog Lipid Res 44:430-48. 2005
    ..the following aspects: gastric emptying, specificity of pancreatic lipase, lymphatic transport and clearance of chylomicrons, effects of lipid structure on tissue lipid compositions and the fecal loss of fats...

Research Grants77

  1. METABOLISM OF INTRAVENOUS LIPID EMULSIONS
    Richard Deckelbaum; Fiscal Year: 2007
    ..These emulsions also serve as models for triglyceride-rich particles (TGRP) such as chylomicrons and VLDL...
  2. ATHEROSCLEROSIS AND PERIPHERAL APOPROTEIN E SYNTHESIS
    David Williams; Fiscal Year: 1999
    ..of high density lipoprotein (HDL), and with remnant particles derived from the intravascular metabolism of chylomicrons and VLDL...
  3. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2000
    ..inhibition of gastric motility is dependent on absorption of lipid by enterocytes, formation and release of chylomicrons and apolipoprotein A-IV (apoA-IV), release of CCK...
  4. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2003
    ..inhibition of gastric motility is dependent on absorption of lipid by enterocytes, formation and release of chylomicrons and apolipoprotein A-IV (apoA-IV), release of CCK...
  5. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2002
    ..inhibition of gastric motility is dependent on absorption of lipid by enterocytes, formation and release of chylomicrons and apolipoprotein A-IV (apoA-IV), release of CCK...
  6. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2001
    ..inhibition of gastric motility is dependent on absorption of lipid by enterocytes, formation and release of chylomicrons and apolipoprotein A-IV (apoA-IV), release of CCK...
  7. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2000
    ..inhibition of gastric motility is dependent on absorption of lipid by enterocytes, formation and release of chylomicrons and apolipoprotein A-IV (apoA-IV), release of CCK...
  8. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 1999
    ..inhibition of gastric motility is dependent on absorption of lipid by enterocytes, formation and release of chylomicrons and apolipoprotein A-IV (apoA-IV), release of CCK...
  9. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2000
    DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
  10. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2002
    DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
  11. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2003
    DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
  12. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2001
    DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
  13. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2010
    ..via the thoracic duct, and it also absorbs lipoproteins directly from the small intestinal villi in the form of chylomicrons. Thus, though it is rarely considered, lymphatic vessels are likely to be key participants in cholesterol ..
  14. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2004
    DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
  15. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2002
    DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
  16. Cholesterol and Lymphatic Transport of Molecules and Cells
    Gwendalyn Randolph; Fiscal Year: 2009
    ..via the thoracic duct, and it also absorbs lipoproteins directly from the small intestinal villi in the form of chylomicrons. Thus, though it is rarely considered, lymphatic vessels are likely to be key participants in cholesterol ..
  17. Biochemistry and Protein Techniques
    Haya Herscovitz; Fiscal Year: 2006
    ..unreadable] Preparative procedures include 1) isolation of lipoproteins, chylomicrons, very low density lipoproteins[unreadable] (VLDL), low density lipoproteins (LDL) and high density lipoproteins ..
  18. GENERAL CLINICAL RESEARCH CENTER
    DANIEL MC CARTY; Fiscal Year: 1980
    ..metabolic and molecular basis of insulin resistance); 4) studies of hyperlipidemia including the clearance of chylomicrons and apo-B (apo-LDL) protein; 5) evaluation of the normal motor function of the esophagus, function and control ..
  19. PHOSPHOLIPID TRANSFER DURING INTESTINAL ABSORPTION
    John Nichols; Fiscal Year: 1992
    ..a portion of the lysophospholipids are reacylated to provide the phospholipid surface coat for the formation of chylomicrons and very low density lipoproteins which carry the bulk of the absorbed cholesterol, triglycerides, and other ..
  20. DIETARY CAROTENOIDS - LIPOPROTEIN/CELL INTERACTIONS
    EARL HARRISON; Fiscal Year: 2002
    ..Specific aims are: 1. Mechanisms of intestinal absorption of carotenoids and their incorporation into chylomicrons in CACO-2 cells in culture...
  21. Chylomicrons promote intestinal absorption and systemic dissemination of dietary
    Erik Eckhardt; Fiscal Year: 2010
    ..have emulsifying properties, which predicts that they show affinity for lipoprotein particles, such as chylomicrons. These large emulsion particles transport dietary long-chain triglycerides (LCT, "fat") through mesenteric ..
  22. ACAT2-Derived LDL Cholesteryl Esters In Atherosclerosis
    Lawrence L Rudel; Fiscal Year: 2011
    ..ACAT2 is known to catalyze synthesis of cholesteryl esters for transport into the body in chylomicrons during intestinal cholesterol absorption. AIM2...
  23. DIETARY CAROTENOIDS - LIPOPROTEIN/CELL INTERACTIONS
    EARL HARRISON; Fiscal Year: 2005
    ..Specific aims are: 1. Mechanisms of intestinal absorption of carotenoids and their incorporation into chylomicrons in CACO-2 cells in culture...
  24. DIETARY CAROTENOIDS - LIPOPROTEIN/CELL INTERACTIONS
    EARL HARRISON; Fiscal Year: 2004
    ..Specific aims are: 1. Mechanisms of intestinal absorption of carotenoids and their incorporation into chylomicrons in CACO-2 cells in culture...
  25. DIETARY CAROTENOIDS - LIPOPROTEIN/CELL INTERACTIONS
    EARL HARRISON; Fiscal Year: 2003
    ..Specific aims are: 1. Mechanisms of intestinal absorption of carotenoids and their incorporation into chylomicrons in CACO-2 cells in culture...
  26. METABOLIC ROLE OF VITAMIN E: CLINICAL & CELLULAR STUDIES
    Herbert Kayden; Fiscal Year: 1990
    ..Studies on the transport of tocopherol in the plasma will investigate the roles of normal lipoproteins (chylomicrons, VLDL, LDL and HDL) and abnormal lipoproteins, including LpX from cholestatic patients...
  27. DIETARY N-3 FATTY ACIDS: TRANSPORT AND UPTAKE INTO BRAIN
    Gregory Anderson; Fiscal Year: 1990
    ..Intravenous injection of radiolabeled saturated, n-6, and n-3 fatty acids, contained in phospholipids, chylomicrons, and as free fatty acids, will test whether there is a preferred chemical form for "brain-destined" fatty acids...
  28. DIETARY N-3 FATTY ACIDS: TRANSPORT AND UPTAKE INTO BRAIN
    Gregory Anderson; Fiscal Year: 1993
    ..Intravenous injection of radiolabeled saturated, n-6, and n-3 fatty acids, contained in phospholipids, chylomicrons, and as free fatty acids, will test whether there is a preferred chemical form for "brain-destined" fatty acids...
  29. GI safety and therapeutics of oil-based PC-NSAIDs
    Lenard Lichtenberger; Fiscal Year: 2004
    ..In the latter studies, we will investigate whether PC promotes the uptake and distribution of the NSAIDs into chylomicrons that enter the lymphatic system...
  30. GI safety and therapeutics of oil-based PC-NSAIDs
    Lenard Lichtenberger; Fiscal Year: 2005
    ..In the latter studies, we will investigate whether PC promotes the uptake and distribution of the NSAIDs into chylomicrons that enter the lymphatic system...
  31. ApoB and ApoA-I Kinetics in the ApoB-67 Mutation
    Francine Welty; Fiscal Year: 2002
    ..apoB-100, produced as very low density lipoprotein (VLDL) apoB-100 in the liver and apoB-48, produced as chylomicrons in the intestine...
  32. Interactions of Lipoproteins with the Vascular Wall
    JOHN CALVERT RUTLEDGE; Fiscal Year: 2010
    ..TGRL consist of chylomicrons, very low density-lipoproteins (VLDL), and their remnant particles...
  33. DIETARY CHOLESTEROL EFFECTS ON PLASMA LIPOPROTEINS
    PHYLLIS MCPHERSON; Fiscal Year: 1990
    ..Retinyl palmitate labelled chylomicrons will be used to determine chylomicron remnant kinetics and attendant changes in the composition of plasma ..
  34. Interactions of Lipoproteins with the Vascular Wall
    John Rutledge; Fiscal Year: 2009
    ..TGRL consist of chylomicrons, very low density-lipoproteins (VLDL), and their remnant particles...
  35. VITAMIN A TRANSPORT DURING LACTATION
    A Ross; Fiscal Year: 1990
    ..model, we will conduct a series of experiments in which lactating rats will receive an intravenous test dose of chylomicrons that have been labeled in vivo with 3H-retinyl esters...
  36. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 1999
    DESCRIPTION (Adapted from applicant's abstract): Apolipoprotein (apo) B-containing lipoproteins include the chylomicrons, VLDL and IDL, and LDL and Lp(a)...
  37. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2007
    ..vein blood, liver, and bile in wild-type and all seven Cyp1 knockout mouse lines, and the role and mechanism of chylomicrons in delivering BaP to target organs; [b] generate liver- and intestinal epithelium-specific Cyp1a1 conditional ..
  38. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2006
    ..vein blood, liver, and bile in wild-type and all seven Cyp1 knockout mouse lines, and the role and mechanism of chylomicrons in delivering BaP to target organs; [b] generate liver- and intestinal epithelium-specific Cyp1a1 conditional ..
  39. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..vein blood, liver, and bile in wild-type and all seven Cyp1 knockout mouse lines, and the role and mechanism of chylomicrons in delivering BaP to target organs;[b] generate liver- and intestinal epithelium-specific Cyp1a1 conditional ..
  40. MPT INHIBITOR IND 50,820 IN FAMILIAL HYPERCHOLESTEROLEM*
    Marina Cuchel; Fiscal Year: 2009
    ..is a protein responsible for transferring lipids onto apolipoprotein B (apo B) in the assembly of intestinal chylomicrons and hepatic very low density lipoprotein (VLDL)...
  41. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..vein blood, liver, and bile in wild-type and all seven Cyp1 knockout mouse lines, and the role and mechanism of chylomicrons in delivering BaP to target organs;[b] generate liver- and intestinal epithelium-specific Cyp1a1 conditional ..
  42. MPT INHIBITOR IND 50,820 IN FAMILIAL HYPERCHOLESTEROLEM*
    Marina Cuchel; Fiscal Year: 2006
    ..is a protein responsible for transferring lipids onto apolipoprotein B (apo B) in the assembly of intestinal chylomicrons and hepatic very low density lipoprotein (VLDL)...
  43. MOLECULAR MECHANISMS OF CHYLOMICRON ASSEMBLY
    M Hussain; Fiscal Year: 2009
    ..We hypothesize that MTP regulates cholesterol ester secretion with chylomicrons by modulating esterification and accretion of cholesterol esters from cytosol to endoplasmic reticulum...
  44. MOLECULAR MECHANISMS OF CHYLOMICRON ASSEMBLY
    M Hussain; Fiscal Year: 2007
    ..We hypothesize that MTP regulates cholesterol ester secretion with chylomicrons by modulating esterification and accretion of cholesterol esters from cytosol to endoplasmic reticulum...
  45. MOLECULAR MECHANISMS OF CHYLOMICRON ASSEMBLY
    M Hussain; Fiscal Year: 2009
    ..We hypothesize that MTP regulates cholesterol ester secretion with chylomicrons by modulating esterification and accretion of cholesterol esters from cytosol to endoplasmic reticulum...
  46. MOLECULAR MECHANISMS OF CHYLOMICRON ASSEMBLY
    M Hussain; Fiscal Year: 2007
    ..We hypothesize that MTP regulates cholesterol ester secretionwith chylomicrons by modulating esterification and accretionof cholesterol esters from cytosol to endoplasmic reticulum...
  47. MOLECULAR MECHANISMS OF CHYLOMICRON ASSEMBLY
    M Mahmood Hussain; Fiscal Year: 2010
    ..We hypothesize that MTP regulates cholesterol ester secretion with chylomicrons by modulating esterification and accretion of cholesterol esters from cytosol to endoplasmic reticulum...
  48. HEPATIC AND LIPOPROTEIN LIPASE INDUCED REMNANT CLEARANCE
    David Chappell; Fiscal Year: 2001
    ..Two lipases, lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL), play central roles in catabolism of chylomicrons and very low-density lipoproteins (VLDL)...
  49. HEPATIC AND LIPOPROTEIN LIPASE INDUCED REMNANT CLEARANCE
    David Chappell; Fiscal Year: 2000
    ..Two lipases, lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL), play central roles in catabolism of chylomicrons and very low-density lipoproteins (VLDL)...
  50. HEPATIC AND LIPOPROTEIN LIPASE INDUCED REMNANT CLEARANCE
    David Chappell; Fiscal Year: 1999
    ..Two lipases, lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL), play central roles in catabolism of chylomicrons and very low-density lipoproteins (VLDL)...
  51. HEPATIC AND LIPOPROTEIN LIPASE INDUCED REMNANT CLEARANCE
    David Chappell; Fiscal Year: 2000
    ..Two lipases, lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL), play central roles in catabolism of chylomicrons and very low-density lipoproteins (VLDL)...
  52. MECHANISM OF APOLIPOPROTEIN B-48 BIOGENESIS
    Lawrence Chan; Fiscal Year: 1993
    ..ApoB-48 is an obligatory component of chylomicrons. In humans, it is synthesized in the small intestine...
  53. LPL-Deficient Cats-A Quantitative Model of Gene Delivery
    PHILIP VULLIET; Fiscal Year: 2009
    ..LPL-/- cats share the identical mutation and cannot hydrolyze chylomicrons resulting in identical aberrations of their plasma lipid profile (PLP)...
  54. LPL-Deficient Cats-A Quantitative Model of Gene Delivery
    PHILIP RICHARD VULLIET; Fiscal Year: 2010
    ..LPL-/- cats share the identical mutation and cannot hydrolyze chylomicrons resulting in identical aberrations of their plasma lipid profile (PLP)...
  55. MECHANISM OF APOLIPOPROTEIN B-48 BIOGENESIS
    Lawrence Chan; Fiscal Year: 1991
    ..ApoB-48 is an obligatory component of chylomicrons. In humans, it is synthesized in the small intestine...
  56. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard Weinberg; Fiscal Year: 2006
    ..by the intestinal enterocytes of mammals during lipid absorption and secreted into lymph on the surface of chylomicrons. Although a broad spectrum of physiologic functions has been proposed for apo A-IV, a preponderance of evidence ..
  57. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard Weinberg; Fiscal Year: 2009
    ..by the intestinal enterocytes of mammals during lipid absorption and secreted into lymph on the surface of chylomicrons. Although a broad spectrum of physiologic functions has been proposed for apo A-IV, a preponderance of evidence ..
  58. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard B Weinberg; Fiscal Year: 2010
    ..by the intestinal enterocytes of mammals during lipid absorption and secreted into lymph on the surface of chylomicrons. Although a broad spectrum of physiologic functions has been proposed for apo A-IV, a preponderance of evidence ..
  59. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard Weinberg; Fiscal Year: 2007
    ..by the intestinal enterocytes of mammals during lipid absorption and secreted into lymph on the surface of chylomicrons. Although a broad spectrum of physiologic functions has been proposed for apo A-IV, a preponderance of evidence ..
  60. REGULATION OF LIPOPROTEIN LIPASE IN HUMAN ADIPOCYTES
    PHILIP KERN; Fiscal Year: 1993
    Lipoprotein lipase (LPL) is an adipocyte enzyme that hydrolyzes the triglyceride core of chylomicrons and VLDL, and human fat obtains essentially all its lipid through the action of LPL...
  61. REGULATION OF INTESTINAL LIPID TRANSPORT
    CHARLES MANSBACH; Fiscal Year: 1992
    ..The fourth aim is to characterize the acyl group composition of the triacylglycerols in chylomicrons, VLDL, mucosa, storage pool, microsomes and Golgi under differing physiological conditions...
  62. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2007
    ..Increases in vagal afferent fiber discharge by lipid depend on the formation of chylomicrons and release of apolipoprotein A-IV, release of CCK and stimulation of CCK1 receptors on vagal afferent ..
  63. Irreversible inhibitors of cholesterol esterase
    LORRAINE DECK; Fiscal Year: 2005
    ..that CE functions within the enterocyte to re-esterify cholesterol in the pathway leading to the formation of chylomicrons. It is our hypothesis that inhibition of any of these functions of CE would provide a new approach to the ..
  64. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2006
    ..Increases in vagal afferent fiber discharge by lipid depend on the formation of chylomicrons and release of apolipoprotein A-IV, release of CCK and stimulation of CCK1 receptors on vagal afferent ..
  65. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2005
    ..Increases in vagal afferent fiber discharge by lipid depend on the formation of chylomicrons and release of apolipoprotein A-IV, release of CCK and stimulation of CCK1 receptors on vagal afferent ..
  66. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2009
    ..Increases in vagal afferent fiber discharge by lipid depend on the formation of chylomicrons and release of apolipoprotein A-IV, release of CCK and stimulation of CCK1 receptors on vagal afferent ..
  67. Irreversible inhibitors of cholesterol esterase
    LORRAINE DECK; Fiscal Year: 2002
    ..that CE functions within the enterocyte to re-esterify cholesterol in the pathway leading to the formation of chylomicrons. It is our hypothesis that inhibition of any of these functions of CE would provide a new approach to the ..
  68. LIPOPROTEIN LIPASE, NUTRITION AND NERVE MYELINATION
    Robert Eckel; Fiscal Year: 2001
    ..enzyme which releases fatty acids and monoacylglyerol from nutrient-dependent triglyceride-rich lipoproteins [chylomicrons and very low density lipoproteins (VLDL)] and regulates the partitioning of these lipid fuels to tissues...
  69. LIPOPROTEIN LIPASE, NUTRITION AND NERVE MYELINATION
    Robert Eckel; Fiscal Year: 2000
    ..enzyme which releases fatty acids and monoacylglyerol from nutrient-dependent triglyceride-rich lipoproteins [chylomicrons and very low density lipoproteins (VLDL)] and regulates the partitioning of these lipid fuels to tissues...
  70. LIPOPROTEIN LIPASE, NUTRITION AND NERVE MYELINATION
    Robert Eckel; Fiscal Year: 1999
    ..enzyme which releases fatty acids and monoacylglyerol from nutrient-dependent triglyceride-rich lipoproteins [chylomicrons and very low density lipoproteins (VLDL)] and regulates the partitioning of these lipid fuels to tissues...
  71. LIPOPROTEIN LIPASE, NUTRITION AND NERVE MYELINATION
    Robert Eckel; Fiscal Year: 2002
    ..enzyme which releases fatty acids and monoacylglyerol from nutrient-dependent triglyceride-rich lipoproteins [chylomicrons and very low density lipoproteins (VLDL)] and regulates the partitioning of these lipid fuels to tissues...