chylomicrons

Summary

Summary: A class of lipoproteins that carry dietary cholesterol and triglycerides from the small intestines to the tissues.

Top Publications

  1. ncbi Chylomicrons promote intestinal absorption of lipopolysaccharides
    Sarbani Ghoshal
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, KY, USA
    J Lipid Res 50:90-7. 2009
  2. pmc Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons
    Anne P Beigneux
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, and Children s Hospital Oakland Research Institute 94609, USA
    Cell Metab 5:279-91. 2007
  3. ncbi Postprandial accumulation of chylomicrons and chylomicron remnants is determined by the clearance capacity
    Martin Adiels
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden
    Atherosclerosis 222:222-8. 2012
  4. ncbi Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both
    S Ishibashi
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    J Biol Chem 271:22422-7. 1996
  5. ncbi Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia
    J R Wetterau
    Department of Metabolic Diseases, Bristol Myers Squibb, Princeton, NJ 08543 4000
    Science 258:999-1001. 1992
  6. ncbi Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80
    Marianne L Lind
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark
    Eur J Pharm Sci 35:211-8. 2008
  7. pmc Triglycerides and heart disease: still a hypothesis?
    Ira J Goldberg
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 31:1716-25. 2011
  8. ncbi Evaluation of a chylomicron flow blocking approach to investigate the intestinal lymphatic transport of lipophilic drugs
    Arik Dahan
    Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, P O Box 12065, Jerusalem 91120, Israel
    Eur J Pharm Sci 24:381-8. 2005
  9. pmc Cholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulation
    Tam M Nguyen
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Lipid Res 53:95-104. 2012
  10. ncbi Measurement of human chylomicron triglyceride clearance with a labeled commercial lipid emulsion
    Y Park
    University of Missouri Kansas City, Department of Medicine and Cardiovascular Research Department, Mid America Heart Institute, Saint Luke s Hospital, 64111, USA
    Lipids 36:115-20. 2001

Detail Information

Publications232 found, 100 shown here

  1. ncbi Chylomicrons promote intestinal absorption of lipopolysaccharides
    Sarbani Ghoshal
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, KY, USA
    J Lipid Res 50:90-7. 2009
    ..The Golgi complex also contains newly formed chylomicrons, the lipoproteins that transport dietary long-chain fat through mesenteric lymph and blood...
  2. pmc Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons
    Anne P Beigneux
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, and Children s Hospital Oakland Research Institute 94609, USA
    Cell Metab 5:279-91. 2007
    The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LpL) along the luminal surface of the capillaries. However, the endothelial cell molecule that facilitates chylomicron processing by LpL has not yet been defined...
  3. ncbi Postprandial accumulation of chylomicrons and chylomicron remnants is determined by the clearance capacity
    Martin Adiels
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden
    Atherosclerosis 222:222-8. 2012
    ..To better understand the postprandial clearance of triglyceride-rich lipoproteins (TRLs) and its relation to the fasting kinetics of TRLs...
  4. ncbi Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both
    S Ishibashi
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    J Biol Chem 271:22422-7. 1996
    ..in the plasma of the LDLR(-/-) mice was distributed in larger subfractions of triglyceride-rich lipoproteins, chylomicrons through very low density lipoprotein-C...
  5. ncbi Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia
    J R Wetterau
    Department of Metabolic Diseases, Bristol Myers Squibb, Princeton, NJ 08543 4000
    Science 258:999-1001. 1992
    ..that is characterized by a defect in the assembly or secretion of plasma very low density lipoproteins and chylomicrons. The microsomal triglyceride transfer protein (MTP), which is located in the lumen of microsomes isolated from ..
  6. ncbi Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80
    Marianne L Lind
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark
    Eur J Pharm Sci 35:211-8. 2008
    ..Furthermore, there was a good correlation between the halofantrine transport to blood and lymphatics in the chylomicron flow blocking model and published results from the mesenteric lymph-cannulated model...
  7. pmc Triglycerides and heart disease: still a hypothesis?
    Ira J Goldberg
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 31:1716-25. 2011
    ..The time is more than ripe for new and creative approaches to understanding the relationship of triglycerides and heart disease...
  8. ncbi Evaluation of a chylomicron flow blocking approach to investigate the intestinal lymphatic transport of lipophilic drugs
    Arik Dahan
    Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, P O Box 12065, Jerusalem 91120, Israel
    Eur J Pharm Sci 24:381-8. 2005
    ..In conclusion, the chemical blockage of chylomicron flow provides a potential approach for lymphatic transport investigation, and may elucidate processes involving in the absorption of lipophilic compounds...
  9. pmc Cholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulation
    Tam M Nguyen
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Lipid Res 53:95-104. 2012
    ..would increase cholesterol absorption efficiency by providing cholesteryl ester (CE) for incorporation into chylomicrons. The assumption was that absorption would be proportional to Acat2 gene dosage...
  10. ncbi Measurement of human chylomicron triglyceride clearance with a labeled commercial lipid emulsion
    Y Park
    University of Missouri Kansas City, Department of Medicine and Cardiovascular Research Department, Mid America Heart Institute, Saint Luke s Hospital, 64111, USA
    Lipids 36:115-20. 2001
    ..Margination was reduced during the fed state, suggesting that native chylomicrons competed with lipid emulsion particles for endothelial lipoprotein lipase...
  11. ncbi Overexpression of apolipoprotein A-IV enhances lipid secretion in IPEC-1 cells by increasing chylomicron size
    Song Lu
    Children s Foundation Research Center at Le Bonheur Children s Medical Center and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
    J Biol Chem 281:3473-83. 2006
    ..The EQQQ-rich region may play an inhibitory or modulatory role in chylomicron packaging in humans...
  12. ncbi Lymphatic chylomicron size is inversely related to biliary phospholipid secretion in mice
    Anniek Werner
    Pediatric Gastroenterology, Department of Pediatrics, Groningen University Institute for Drug Exploration, University Medical Center Groningen, University of Groningen, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 290:G1177-85. 2006
    ..Altered CM size may have physiological consequences for postprandial CM processing...
  13. pmc Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects
    Remco Franssen
    Department of Vascular Medicine, Academic Medical Center Amsterdam, The Netherlands
    Circ Cardiovasc Genet 3:169-78. 2010
    ....
  14. ncbi CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine
    Fatiha Nassir
    Department of Medicine, Division of Nutritional Science, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:19493-501. 2007
    ..The findings support the role of CD36 in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, whereas CD36-independent mechanisms predominate in distal segments...
  15. ncbi The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins
    Peter J O'Brien
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Clin Chem 51:351-9. 2005
    ..Despite these compelling molecular biology data, relatively little is known about ApoA5 protein in human serum...
  16. ncbi COPII proteins are required for Golgi fusion but not for endoplasmic reticulum budding of the pre-chylomicron transport vesicle
    Shadab A Siddiqi
    Division of Gastroenterology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Cell Sci 116:415-27. 2003
    ..Together, these findings suggest that COPII proteins may not be required for the exit of membrane-bound chylomicrons from the ER but that they or other proteins may be necessary for PCTV fusion with the Golgi.
  17. ncbi A proposed model for the assembly of chylomicrons
    M M Hussain
    Department of Biochemistry, School of Medicine, MCP Hahnemann University, Philadelphia, PA 19129, USA
    Atherosclerosis 148:1-15. 2000
    The intestine synthesizes very low density lipoproteins (VLDL) and chylomicrons (CM) to transport fat and fat-soluble vitamins into the blood...
  18. ncbi Postprandial dyslipidemia in men with visceral obesity: an effect of reduced LDL receptor expression?
    J C Mamo
    Department of Nutrition, Dietetics and Food Sciences, School of Public Health, Curtin University of Technology, Perth 6845, Australia
    Am J Physiol Endocrinol Metab 281:E626-32. 2001
    ..ml(-1). h; RP: 3,120 +/- 511 vs. 1,308 +/- 177 U. ml(-1). h, respectively). A delay in the conversion of chylomicrons to remnants probably contributed to postprandial dyslipidemia in viscerally obese subjects...
  19. ncbi Scavenger receptor BI plays a role in facilitating chylomicron metabolism
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, 2300 RA Leiden, The Netherlands
    J Biol Chem 279:18401-6. 2004
    ....
  20. ncbi A new method for the study of chylomicron kinetics in vivo
    Y Park
    Department of Medicine, University of Missouri Kansas City, St Luke s Hospital, Kansas City, Missouri 64111, USA
    Am J Physiol Endocrinol Metab 279:E1258-63. 2000
    Our understanding of the metabolism of chylomicrons, the lipoprotein that transports dietary fat from the intestine to peripheral tissues, is incomplete...
  21. ncbi Effects of prior moderate exercise on exogenous and endogenous lipid metabolism and plasma factor VII activity
    J M Gill
    Human Muscle Metabolism Research Group, Loughborough University, Loughborough, LE113TU, UK
    Clin Sci (Lond) 100:517-27. 2001
    ....
  22. pmc Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 49:1312-21. 2008
    ..GPIHBP1 binds both LPL and chylomicrons and is expressed on the luminal face of microvascular endothelial cells...
  23. ncbi A novel method for measuring intestinal and hepatic triacylglycerol kinetics
    Feifei Sun
    Diabetes and Metabolic Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom and
    Am J Physiol Endocrinol Metab 305:E1041-7. 2013
    ..In fed study 2, 47% of the total TAG production rate (CM + VLDL1) was from CM. This methodology may be a useful tool for understanding the abnormalities in postprandial TAG kinetics in metabolic syndrome and type 2 diabetes...
  24. ncbi Absence of acute inhibitory effect of insulin on chylomicron production in type 2 diabetes
    Juan Patricio Nogueira
    Unité Mixte de Recherche Institut National de la Recherche Agronomique, University of La Méditerranée, Marseille, France
    Arterioscler Thromb Vasc Biol 32:1039-44. 2012
    Overproduction of intestinally derived apoB-48-containing triglyceride-rich lipoproteins (TRLs) (chylomicrons) has recently been described in type 2 diabetes, as is known for hepatic TRL-apoB-100 (very-low-density lipoprotein) production...
  25. pmc CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood
    Victor A Drover
    Department of Physiology and Biophysics, State University of New York at Stony Brook, USA
    J Clin Invest 115:1290-7. 2005
    ..CD36 deficiency results in hypertriglyceridemia both in the postprandial and fasting states and in humans may constitute a risk factor for diet-induced type 2 diabetes and cardiovascular disease...
  26. ncbi Amounts and types of fatty acids in meals affect the pattern of retinoids secreted in human chylomicrons after a high-dose preformed vitamin A intake
    Patrick Sauvant
    Unite Maladies Metaboliques et Micronutriments, INRA, Clermont Ferrand Theix, Saint Genes Champanelle, France
    Metabolism 52:514-9. 2003
    ..Newly absorbed vitamin A is secreted mainly as retinyl esters in chylomicrons. The effect of changing types and amounts of fatty acids on fatty acid composition of chylomicron retinoid ..
  27. pmc Interchange of apolipoproteins between chylomicrons and high density lipoproteins during alimentary lipemia in man
    R J Havel
    J Clin Invest 52:32-8. 1973
    ..The increased activator content of triglyceride-rich lipoproteins was virtually confined to chylomicrons and its concentration in chylomicron apoprotein was substantially greater than that in very low density ..
  28. ncbi Influence of triacylglycerol structure on the postprandial response of factor VII to stearic acid-rich fats
    Thomas A B Sanders
    Department of Nutrition and Dietetics, Nutrition Food and Health Research Centre, King s College London, United Kingdom
    Am J Clin Nutr 77:777-82. 2003
    ..It was hypothesized that this difference is a consequence of the differences in structure between the 2 triacylglycerols...
  29. ncbi Chylomicron remnant metabolism studied with a new breath test in postmenopausal women with and without type 2 diabetes mellitus
    C A Dane-Stewart
    University Department of Medicine, Royal Perth Hospital, University of Western Australia and Western Australian Institute for Medical Research, Perth, Australia
    Clin Endocrinol (Oxf) 58:415-20. 2003
    ..We investigated chylomicron remnant metabolism using a stable isotope breath test and fasting measurements of plasma apolipoprotein (apo) B-48 and apoC-III concentrations in postmenopausal women with and without type 2 DM...
  30. ncbi Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency
    R L Hamilton
    Cardiovascular Research Institute, University of California, San Francisco 94143 0452, USA
    J Lipid Res 39:1543-57. 1998
    ..for packaging large quantities of neutral lipids into apolipoprotein (apo) B-containing lipoproteins (chylomicrons or VLDL) are incompletely understood...
  31. ncbi A new function of Vitamin E-TPGS in the intestinal lymphatic transport of lipophilic drugs: enhancing the secretion of chylomicrons
    Zhuoyang Fan
    Key Laboratory of Smart Drug Delivery Fudan University, Ministry of Education and PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, China
    Int J Pharm 445:141-7. 2013
    The purpose of this study was to examine whether Vitamin E-TPGS had a function in promoting the secretion of chylomicrons in enterocytes...
  32. ncbi Macrophages take up triacylglycerol-rich emulsions at a faster rate upon co-incubation with native and modified LDL: An investigation on the role of natural chylomicrons in atherosclerosis
    Márcia D T Carvalho
    Lipids Laboratory LIM 10, University of Sao Paulo Medical School, Sao Paulo, Brazil
    J Cell Biochem 84:309-23. 2002
    b>Chylomicrons play a role in atherosclerosis, however, because the mechanisms involved in the cell uptake of these particles are not fully understood, investigations were carried out using a radioactively labeled protein-free ..
  33. ncbi Genes that affect cholesterol synthesis, cholesterol absorption, and chylomicron assembly: the relationship between the liver and intestine in control and streptozotosin diabetic rats
    Sean Lally
    Department of Diabetes and Endocrinology, Trinity College, Dublin 18, Ireland
    Metabolism 56:430-8. 2007
    b>Chylomicrons and very low-density lipoproteins (VLDLs) are abnormal in diabetes...
  34. ncbi Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons
    Frederik Van Dyck
    Department of Human Genetics, University of Leuven, B 3000 Leuven, Belgium
    Cell Metab 6:406-13. 2007
    ..Although chylomicrons are known to assemble in part within membrane secretory pathways, the modifications required for efficient ..
  35. ncbi Atorvastatin improves postprandial lipoprotein metabolism in normolipidemlic subjects
    K G Parhofer
    Department of Internal Medicine II, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Clin Endocrinol Metab 85:4224-30. 2000
    ....
  36. ncbi The unsaponifiable fraction of virgin olive oil in chylomicrons from men improves the balance between vasoprotective and prothrombotic factors released by endothelial cells
    Javier S Perona
    Instituto de la Grasa CSIC, 41012 Sevilla, Spain
    J Nutr 134:3284-9. 2004
    ....
  37. ncbi Acceleration of uptake of LDL but not chylomicrons or chylomicron remnants by cells that secrete apoE and hepatic lipase
    S Y Choi
    Research Institute, Palo Alto Medical Foundation, CA 94301
    J Lipid Res 35:848-59. 1994
    ..125I-labeled LDL, chylomicron remnants, or chylomicrons were added to media at concentrations near their Kd...
  38. pmc The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium
    Alexander Jaschke
    Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam Rehbruecke, D 14558 Nuthetal, Germany
    Hum Mol Genet 21:3128-42. 2012
    ..Here, we describe the essential role of ARFRP1 and its interaction with Rab2 in the assembly and lipidation of chylomicrons in the intestinal epithelium...
  39. pmc Postprandial lipoprotein metabolism: VLDL vs chylomicrons
    Katsuyuki Nakajima
    School of Health Sciences, Faculty of Medicine, Gunma University, Maebashi, Gunma, Japan
    Clin Chim Acta 412:1306-18. 2011
    Since Zilversmit first proposed postprandial lipemia as the most common risk of cardiovascular disease, chylomicrons (CM) and CM remnants have been thought to be the major lipoproteins which are increased in the postprandial ..
  40. ncbi Chylomicrons in disease-future challenges Invited keynote address
    Trevor G Redgrave
    Physiology, School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Nedlands, Western Australia 6009, Australia
    Atheroscler Suppl 9:3-6. 2008
    ..Acceptance of the premise that chylomicrons play a key role in atherogenesis brings new understanding to the mechanisms underlying empirical risk-reduction ..
  41. ncbi Incorporation of carotenoids from paprika oleoresin into human chylomicrons
    Antonio Pérez-Gálvez
    Institute for Physiological Chemistry I, Henrich Heine University Düsseldorf, Dusseldorf, Germany
    Br J Nutr 89:787-93. 2003
    ..However, oleoresin is a suitable source for the provitamin A carotenoids beta-carotene and beta-cryptoxanthin and the macular pigment zeaxanthin...
  42. ncbi Uptake of lipophilic drugs by plasma derived isolated chylomicrons: linear correlation with intestinal lymphatic bioavailability
    Pavel Gershkovich
    Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, P O Box 12065, 91120 Jerusalem, Israel
    Eur J Pharm Sci 26:394-404. 2005
    Association of a drug with chylomicrons in the enterocyte is an essential step in the lymphatic absorption pathway...
  43. pmc Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Biochim Biophys Acta 1771:1464-8. 2007
    ..A hallmark of GPIHBP1 is the ability to bind lipoprotein lipase, chylomicrons, and apolipoprotein (apo-) AV...
  44. ncbi Are we ready for a prospective study to investigate the role of chylomicrons in cardiovascular disease?
    Jeffrey S Cohn
    Nutrition and Metabolism Group, Heart Research Institute, 114 Pyrmont Bridge Road, Camperdown, NSW 2050, Australia
    Atheroscler Suppl 9:15-8. 2008
    Intestinal chylomicrons and their remnants are believed to contribute both directly and indirectly to the onset and development of atherosclerosis...
  45. ncbi Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage
    Toralph Ruge
    Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford OX3 7LJ, United Kingdom
    J Clin Endocrinol Metab 94:1781-8. 2009
    ..Adipose tissue sequesters dietary fat and thus protects other tissues from excess fat exposure, especially after meals...
  46. ncbi Paraoxonase 1 (PON1) is present in postprandial chylomicrons
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 180:55-61. 2005
    ..As diet affects serum PON1 activity, we questioned whether PON1 is also carried by postprandial chylomicrons. Chylomicrons were isolated by ultracentrifugation from plasma of 10 healthy men, 3h after the consumption of a ..
  47. ncbi The biogenesis of chylomicrons
    Charles M Mansbach
    The University of Tennessee Health Science Center and the Veterans Administration Medical Center, Memphis, TN 38163, USA
    Annu Rev Physiol 72:315-33. 2010
    ....
  48. pmc The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Mol Endocrinol 22:2496-504. 2008
    ..GPIHBP1 binds lipoprotein lipase and chylomicrons and is expressed along the luminal surface of microvascular endothelial cells...
  49. ncbi Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons
    Emile Levy
    Department of Nutrition, Hôpital Sainte Justine and University of Montreal, Montreal, Quebec H3T 1C5, Canada
    J Biol Chem 277:16470-7. 2002
    ..The occurrence of membrane-associated apoB in the Golgi, coupled with its interaction with active MTP, suggests an important role for the Golgi in the biogenesis of apoB-containing lipoproteins...
  50. pmc Accelerated lipid absorption in mice overexpressing intestinal SR-BI
    Florence Bietrix
    INSERM U 563, Centre de Physiopathologie de Toulouse Purpan, Département Lipoprotéines et Médiateurs Lipidiques, IFR30 and Université Paul Sabatier, 31024 Toulouse Cedex 3, France
    J Biol Chem 281:7214-9. 2006
    ..Thus, we described for the first time a functional role in vivo for SR-BI in cholesterol but also in triglyceride intestinal absorption...
  51. pmc Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 29:956-62. 2009
    GPIHBP1 is an endothelial cell protein that binds lipoprotein lipase (LPL) and chylomicrons. Because GPIHBP1 deficiency causes chylomicronemia in mice, we sought to determine whether some cases of chylomicronemia in humans could be ..
  52. ncbi APOLIPOPROTEIN B: mRNA editing, lipoprotein assembly, and presecretory degradation
    N O Davidson
    Departments of Medicine and Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Annu Rev Nutr 20:169-93. 2000
    ..These droplets fuse with nascent apoB-containing particles to form mature, very low-density lipoproteins or chylomicrons. In cultured hepatic cells, lipid availability dictates the rate of apoB production...
  53. ncbi Development and physiological regulation of intestinal lipid absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons
    Charles M Mansbach
    Division of Gastroenterology, The Univ of Tennessee Health Science Center, 920 Madison Ave, Suite 240, Memphis, TN 38163, USA
    Am J Physiol Gastrointest Liver Physiol 293:G645-50. 2007
    ..aspects of this process from the mechanisms of fatty acid uptake to the control of triacylglycerol export in chylomicrons. Recent advances have included the identification of a number of fatty acid transporters, the discovery of ..
  54. ncbi Cellular aspects of intestinal lipoprotein assembly in Psammomys obesus: a model of insulin resistance and type 2 diabetes
    Monika Zoltowska
    Department of Nutrition, Centre de Recherche, Hopital Sainte Justine, and Université de Montréal, Montreal, Quebec, Canada
    Diabetes 52:2539-45. 2003
    ..exhibited high levels of triglycerides (TGs) in the plasma and intestine and postprandial plasma chylomicrons and apo B-48 compared with normoglycemic/normoinsulinemic animals...
  55. ncbi Development and physiological regulation of intestinal lipid absorption. I. Development of intestinal lipid absorption: cellular events in chylomicron assembly and secretion
    Dennis D Black
    Children s Foundation Research Center of Memphis, Le Bonheur Children s Medical Center, 50 N Dunlap Street, Memphis, TN 38103, USA
    Am J Physiol Gastrointest Liver Physiol 293:G519-24. 2007
    The newborn mammal must efficiently absorb dietary fat, predominantly as triacylglycerol, and produce chylomicrons to deliver this lipid to peripheral tissues...
  56. pmc Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptake
    Kalyani G Bharadwaj
    Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 285:37976-86. 2010
    ..However, LpL but not CD36 deficiency decreased VLDL-cholesteryl ester uptake. Endogenously labeled mouse chylomicrons were produced by tamoxifen treatment of β-actin-MerCreMer/LpL(flox/flox) mice...
  57. pmc Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia
    Gunilla Olivecrona
    Department of Medical Biosciences Physiological Chemistry, Umea University, Umea, Sweden
    J Lipid Res 51:1535-45. 2010
    ..Thus, the conserved cysteines in the Ly6 domain are crucial for GPIHBP1 function...
  58. pmc The identification of a novel endoplasmic reticulum to Golgi SNARE complex used by the prechylomicron transport vesicle
    Shadab A Siddiqi
    Division of Gastroenterology, University of Tennessee Health Science Center, Memphis, 38163, USA
    J Biol Chem 281:20974-82. 2006
    ..The rate-limiting step in the transit of chylomicrons through the enterocyte is the exit of chylomicrons from the endoplasmic reticulum in prechylomicron transport ..
  59. ncbi Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells
    Alexandrine During
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Lipid Res 48:2283-94. 2007
    ..efflux into basolateral medium (BM) increased linearly with time, ROL in the nonlipoprotein fraction and REs in chylomicrons (CMs). In contrast to carotenoids, ROL uptake was proportional to ROL concentration (0.5-110 microM)...
  60. ncbi Size distributions of chylomicrons from human lymph from dynamic light scattering measurements
    H Ruf
    Max Planck Institut fur Biophysik, Frankfurt a M, Germany
    Eur Biophys J 28:1-11. 1999
    b>Chylomicrons, the vehicles for the transport of exogeneous triglycerides and cholesterol in the lymph and the blood, were characterized by their size from dynamic light scattering measurements...
  61. ncbi Variable phenotypic expression of chylomicron retention disease in a kindred carrying a mutation of the Sara2 gene
    Angelo B Cefalù
    Departmet of Clinical Medicine and Emerging Diseases, University of Palermo, I 90127 Palermo, Italy
    Metabolism 59:463-7. 2010
    ..More studies are needed to understand the reasons of the phenotypic variability of the same molecular defect in the same family...
  62. ncbi Postprandial chylomicrons: potent vehicles for transporting cholesterol from endogenous LDL+HDL and cell membranes to the liver via LCAT and CETP
    Byung Hong Chung
    Atherosclerosis Research Unit, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Lipid Res 45:1242-55. 2004
    We examined whether postprandial (PP) chylomicrons (CMs) can serve as vehicles for transporting cholesterol from endogenous cholesterol-rich lipoprotein (LDL+HDL) fractions and cell membranes to the liver via lecithin:cholesterol ..
  63. ncbi Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, 2300 RA Leiden, The Netherlands
    J Lipid Res 46:1172-81. 2005
    ....
  64. ncbi Vitamin A intake affects the contribution of chylomicrons vs. retinol-binding protein to milk vitamin A in lactating rats
    M H Green
    Nutrition Department, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 131:1279-82. 2001
    To investigate the influence of vitamin A intake on the contribution of chylomicrons vs...
  65. pmc Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor
    J Herz
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Proc Natl Acad Sci U S A 92:4611-5. 1995
    ..The rate of chylomicron remnant removal by the liver was normal up to 30 min after intravenous injection of chylomicrons into LDLR (-/-) mice and was unaffected by receptor-associated protein (RAP), a potent inhibitor of ligand ..
  66. pmc Homozygous missense mutation (G56R) in glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPI-HBP1) in two siblings with fasting chylomicronemia (MIM 144650)
    Jian Wang
    Schulich School of Medicine and Dentistry, University of Western Ontario and Vascular Biology Research Group, Robarts Research Institute, London, Ontario, N6A 5K8, Canada
    Lipids Health Dis 6:23. 2007
    ....
  67. ncbi Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons
    Anita C E Vreugdenhil
    Nutrition and Toxicology Research Institute Maastricht, Department of General Surgery, Maastricht University, Maastricht, The Netherlands
    J Immunol 170:1399-405. 2003
    b>Chylomicrons have been shown to protect against endotoxin-induced lethality. LPS-binding protein (LBP) is involved in the inactivation of bacterial toxin by lipoproteins...
  68. ncbi Olive oil increases the number of triacylglycerol-rich chylomicron particles compared with other oils: an effect retained when a second standard meal is fed
    Kim G Jackson
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, United Kingdom
    Am J Clin Nutr 76:942-9. 2002
    ..There is a rapid appearance of chylomicrons in the circulation carrying fat ingested with the first meal, with a peak 1 h after the second meal.
  69. pmc Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT)
    Sheila M O'Byrne
    Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 280:35647-57. 2005
    ..Lrat-/- mice absorb dietary retinol primarily as free retinol in chylomicrons; however, retinyl esters are also present within the chylomicron fraction obtained from Lrat-/- mice...
  70. ncbi Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation
    F Karpe
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK
    Biochem Soc Trans 35:472-6. 2007
    The triacylglycerol content of chylomicrons and VLDL (very-low-density lipoprotein) compete for the same lipolytic pathway in the capillary beds...
  71. ncbi Plasma clearance and liver uptake of chylomicron remnants generated by hepatic lipase lipolysis: evidence for a lactoferrin-sensitive and apolipoprotein E-independent pathway
    S E Crawford
    Department of Pathology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Lipid Res 40:797-805. 1999
    b>Chylomicrons labeled with [3H]cholesterol and [14C]triglyceride fatty acids were lipolyzed by hepatic lipase (HL) in vitro and then injected intravenously into normal mice fed low- or high-fat diets, and into apolipoprotein (apo) E-..
  72. ncbi Metabolism of very-low-density lipoprotein and chylomicrons by streptozotocin-induced diabetic rat heart: effects of diabetes and lipoprotein preference
    You Guo Niu
    Department of Clinical Aerospace Medicine, The Fourth Military Medical University, Xi an, China
    Am J Physiol Endocrinol Metab 295:E1106-16. 2008
    Very-low-density lipoprotein (VLDL) and chylomicrons (CM) are major sources of fatty acid supply to the heart, but little is known about their metabolism in diabetic myocardium...
  73. ncbi Carboxyl ester lipase overexpression in rat hepatoma cells and CEL deficiency in mice have no impact on hepatic uptake or metabolism of chylomicron-retinyl ester
    A M Van Bennekum
    Department of Biochemistry, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19129, USA
    Biochemistry 38:4150-6. 1999
    ....
  74. ncbi Anderson or chylomicron retention disease: molecular impact of five mutations in the SAR1B gene on the structure and the functionality of Sar1b protein
    Mathilde Charcosset
    UF Lipides Dyslipidémies, Laboratoire de Biochimie, CBE, 59 Boulevard Pinel, Bron Cedex, France
    Mol Genet Metab 93:74-84. 2008
    ..A determination of the specific mutation in Anderson disease or CMRD is required to ensure diagnosis and allow prompt therapeutic intervention in these children...
  75. ncbi Intestinal lipoprotein assembly
    M Mahmood Hussain
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Curr Opin Lipidol 16:281-5. 2005
    ..In this review we propose a nomenclature for these lipoproteins and have summarized recent data about their intracellular assembly and factors that modulate their secretion...
  76. ncbi Postprandial lipoproteins and atherosclerosis
    K C Yu
    Research Institute, Ames Building, Palo Alto Medical Foundation 795 El Camino Real, Palo Alto, CA 94301, USA
    Front Biosci 6:D332-54. 2001
    ..state, dietary lipid is transported from the intestine to peripheral tissues by plasma lipoproteins called chylomicrons. In the capillary beds of peripheral tissues, chylomicron triglycerides are lipolyzed by the enzyme, ..
  77. pmc Normotriglyceridemic abetalipoproteinemia. absence of the B-100 apolipoprotein
    M J Malloy
    J Clin Invest 67:1441-50. 1981
    ..and very low density lipoproteins are absent, but in which triglycerides are absorbed from the intestine and chylomicrons are present in plasma...
  78. ncbi The diurnal rhythms of cholesterol metabolism and plasma clearance of model chylomicrons: comparison of normal and genetically hypercholesterolemic rats (RICO)
    B C Mortimer
    Department of Physiology, University of Western Australia, Nedlands, Australia
    Comp Biochem Physiol A Mol Integr Physiol 120:671-80. 1998
    Previous studies showed a slower clearance of cholesterol-labeled lymph chylomicrons in genetically hypercholesterolemic rats (RICO) compared with normocholesterolemic rats...
  79. ncbi Decreased hepatic expression of the low-density lipoprotein (LDL) receptor and LDL receptor-related protein in aging rats is associated with delayed clearance of chylomicrons from the circulation
    P A Field
    Metabolic Research Laboratory, Oxford Lipid Metabolism Group, University of Oxford, UK
    Metabolism 49:492-8. 2000
    ..intravenously injected bolus of 14C-labeled cholesterol ester (CE) and 3H-labeled triacylglycerol (TAG) lymph chylomicrons was markedly delayed in the old rats (P < .05)...
  80. ncbi Fibrinogen in rat gastrointestinal lymph before, during and after intraduodenal administration of emulsified triglyceride: fibrinogen bound to chylomicrons in gastrointestinal lymph is functional
    Ashley P DeAnglis
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Thromb Res 105:419-32. 2002
    ..Levels of the same analytes changed little, if at all, in control animals. As assessed using immunoblotting, chylomicrons in gastrointestinal lymph are coated with fibrinogen...
  81. ncbi Postprandial chylomicrons and adipose tissue lipoprotein lipase are altered in type 2 diabetes independently of obesity and whole-body insulin resistance
    Giovanni Annuzzi
    Department of Clinical and Experimental Medicine, Federico II University, Via Pansini 5, 80131 Naples, Italy
    Nutr Metab Cardiovasc Dis 18:531-8. 2008
    ..The aim of this study is to differentiate the effects of whole-body insulin resistance, obesity, and type 2 diabetes on postprandial dyslipidaemia and lipoprotein lipase (LPL) in adipose tissue...
  82. ncbi Effects of palm oil and transesterified palm oil on chylomicron and VLDL triacylglycerol structures and postprandial lipid response
    K Yli-Jokipii
    Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014 Turku, Finland
    J Lipid Res 42:1618-25. 2001
    The effects of positional distribution of triacylglycerol (TAG) fatty acids to TAG structures in chylomicrons and VLDL, and to postprandial lipemia, were studied in 10 healthy premenopausal women using a 6-h oral fat load test and a ..
  83. ncbi Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders
    Bethan Jones
    Genomic and Molecular Medicine Group, MRC Clinical Sciences Centre, Imperial College, London, England, UK
    Nat Genet 34:29-31. 2003
    ..Our data suggest that chylomicrons, which vastly exceed the size of typical COPII vesicles, are selectively recruited by the COPII machinery for ..
  84. ncbi Retinyl ester secretion by intestinal cells: a specific and regulated process dependent on assembly and secretion of chylomicrons
    N Nayak
    Department of Biochemistry, School of Medicine, MCP Hahnemann University, Philadelphia, PA 19129, USA
    J Lipid Res 42:272-80. 2001
    ..We propose that RE are added to CM during final stages of lipoprotein assembly and may serve as signposts for these steps...
  85. ncbi Effect of dietary fatty acids on the postprandial fatty acid composition of triacylglycerol-rich lipoproteins in healthy male subjects
    A Bysted
    BioCentrum DTU, Section of Biochemistry and Nutrition, Center of Advanced Food Studies, The Technical University of Denmark, Lyngby, Denmark
    Eur J Clin Nutr 59:24-34. 2005
    The aim of the present study was to investigate the effect of trans-18:1 isomers compared to other fatty acids, especially saturates, on the postprandial fatty acid composition of triacylglycerols (TAG) in chylomicrons and VLDL.
  86. pmc Mobilisation of enterocyte fat stores by oral glucose in humans
    M D Robertson
    Metabolic Research Group, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, UK
    Gut 52:834-9. 2003
    ..The aim of this study was to investigate the location and release of lipid from within the gastrointestinal tract...
  87. pmc GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons
    Stephen G Young
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Curr Opin Lipidol 18:389-96. 2007
    To summarize recent data indicating that glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) plays a key role in the lipolytic processing of chylomicrons.
  88. ncbi Effect of oxidized lipids in the diet on oxidized lipid levels in postprandial serum chylomicrons of diabetic patients
    I Staprans
    Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Diabetes Care 22:300-6. 1999
    ..To determine whether humans with type 2 diabetes have increased levels of oxidized fatty acids in their serum chylomicron fraction after the ingestion of dietary oxidized fatty acids...
  89. ncbi Glibenclamide improves postprandial hypertriglyceridaemia in type 2 diabetic patients by reducing chylomicrons but not the very low-density lipoprotein subfraction levels
    I Skrapari
    1st Department Propaedeutic Medicine, Athens University Medical School, Laiko General Hospital, Athens, Greece
    Diabet Med 18:781-5. 2001
    ..Total triglyceride levels in plasma, in chylomicrons (CM), in CM-deficient plasma, in very low-density lipoprotein (VLDL) subfractions (VLDL-1, VLDL-2) and in ..
  90. ncbi The incorporation and metabolism of amyloid-beta into chylomicron-like lipid emulsions
    Anthony P James
    Department of Nutrition, Dietetics and Food Science, Curtin University of Technology, Perth, Australia
    J Alzheimers Dis 5:179-88. 2003
    ..Chylomicron-like lipid emulsions, resembling chylomicrons in composition, size and metabolism were prepared in the presence of [125I]Abeta1-40...
  91. ncbi Chylomicron and VLDL TAG structures and postprandial lipid response induced by lard and modified lard
    Kaisa M Yli-Jokipii
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    Lipids 38:693-703. 2003
    ..were less TAG with palmitic acid in the sn-2 position and more TAG with oleic acid in the sn-2 position in chylomicrons than in fat ingested. From 1...
  92. ncbi The intracellular transport of chylomicrons requires the small GTPase, Sar1b
    Carol C Shoulders
    Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Curr Opin Lipidol 15:191-7. 2004
    ..This review focuses on the assembly and structural evolution of COPII (coat protein) transport carriers that are essential for the transport of chylomicrons from the endoplasmic reticulum to the Golgi apparatus.
  93. ncbi The mechanism of the formation and secretion of chylomicrons
    Tammy Kindel
    University of Cincinnati College of Medicine, United States
    Atheroscler Suppl 11:11-6. 2010
    ..luminal digestion, followed by cellular uptake and processing, and subsequent extracellular transport of chylomicrons. We discuss the importance of acid and pancreatic lipase in lipid digestion...
  94. pmc Chylomicrons promote intestinal absorption and systemic dissemination of dietary antigen (ovalbumin) in mice
    Yuehui Wang
    Department of Internal Medicine, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 4:e8442. 2009
    ..contain long-chain triglycerides (LCT), which stimulate mesenteric lymph flux and postprandial transport of chylomicrons through mesenteric lymph nodes (MLN) and blood...
  95. ncbi Three-dimensional immunofluorescent double labelling using polyclonal antibodies derived from the same species: enterocytic colocalization of chylomicrons with Golgi apparatus
    R Takechi
    Australian Technology Centre for Metabolic Fitness, School of Public Health, Division of Health Sciences, Curtin University of Technology, GPO Box U1987, Perth, WA, 6845, Australia
    Histochem Cell Biol 129:779-84. 2008
    ..Colocalization of apo B and Golgi apparatus (75.2 +/- 8.5%) is consistent with the purported mode of secretion of these macromolecules...
  96. pmc Vesicle-associated membrane protein 7 is expressed in intestinal ER
    Shadab A Siddiqi
    Division of Gastroenterology, The University of Tennessee Health Science Center, Memphis, TN 38163 USA
    J Cell Sci 119:943-50. 2006
    ..We conclude that VAMP7 is enriched in intestinal ER and that it plays a functional role in the delivery of triacylglycerol from the ER to the Golgi...
  97. ncbi Signposts in the assembly of chylomicrons
    M M Hussain
    Departments of Anatomy and Cell Biology, and Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Front Biosci 6:D320-31. 2001
    Intestinal cells synthesize and secrete chylomicrons in the postprandial state. Synthesis of these particles is defective in abetalipoproteinemia and chylomicron retention disease...
  98. ncbi Vegetable-borne lutein, lycopene, and beta-carotene compete for incorporation into chylomicrons, with no adverse effect on the medium-term (3-wk) plasma status of carotenoids in humans
    Viviane Tyssandier
    Unite Maladies Metaboliques et Micronutriments, INRA, Clermont Ferrand Theix, Saint Genes Champanelle, France
    Am J Clin Nutr 75:526-34. 2002
    ..The results of epidemiologic studies have consistently shown associations between dietary intake or plasma carotenoid status and incidence of cancers and cardiovascular and eye diseases...
  99. ncbi The elevation of ingested lipids within plasma chylomicrons is prolonged in men compared with women
    Nicolas D Knuth
    Substrate Metabolism Laboratory, Division of Kinesiology, University of Michigan, Ann Arbor, MI 48109 2214, USA
    J Nutr 136:1498-503. 2006
    ..The purpose of this study was to measure the recovery of ingested fat in plasma fractions of chylomicrons (CHYLO), VLDL, and plasma fatty acids, as well as in expired breath (i.e., oxidation) in men and women...
  100. ncbi Sitosterol and cholesterol in chylomicrons of type 2 diabetic and non-diabetic subjects: the relationship with ATP binding cassette proteins G5 and G8 and Niemann-Pick C1-like 1 mRNA
    S E Lally
    Diabetologia 50:217-9. 2007
  101. ncbi Butter differs from olive oil and sunflower oil in its effects on postprandial lipemia and triacylglycerol-rich lipoproteins after single mixed meals in healthy young men
    Nadia Mekki
    Unité 476 Institut National de la Santé et de la Recherche Médicale, Human Nutrition and Lipids, National Institute of Health and Medical Research, Universite de la Mediterranee, 13009 Marseille, France
    J Nutr 132:3642-9. 2002
    ..The butter meal induced a lower postprandial rise of triacylglycerols in serum and chylomicrons (incremental AUC, mmol.h/L: 0.72) than the two unsaturated oils (olive oil: 1.6, sunflower oil: 1...

Research Grants63

  1. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2012
    ..via the thoracic duct, and it also absorbs lipoproteins directly from the small intestinal villi in the form of chylomicrons. Thus, though it is rarely considered, lymphatic vessels are likely to be key participants in cholesterol ..
  2. Lipoprotein Structure and Function by Individual Particle Electron Tomography
    Gang Ren; Fiscal Year: 2013
    ..high , low-, intermediate- and very low-density lipoproteins (HDL, LDL, IDL and VLDL respectively), as well as chylomicrons;HDL and LDL are major players in plasma cholesterol metabolism...
  3. Gut mucosal mast cells are activated by fat absorption: physiology and mechanism
    Patrick Tso; Fiscal Year: 2013
    ..We hypothesized that the absorption of lipids and the formation and secretion of chylomicrons (CMs) activate the MMCs. This action is lipid specific and is not shared by proteins or carbohydrates...
  4. Inhibition of Fat Absorption as a Mechanism to Treat Obesity
    CHARLES MILTON MANSBACH; Fiscal Year: 2013
    ..We know the proteins that select cargo chylomicrons for inclusion in the vesicle and the protein that initiates this process...
  5. Interactions of Lipoproteins with the Vascular Wall
    JOHN CALVERT RUTLEDGE; Fiscal Year: 2010
    ..TGRL consist of chylomicrons, very low density-lipoproteins (VLDL), and their remnant particles...
  6. Role of mesenteric lymphatics and dietary endotoxin in metabolic syndrome
    DAVID CARL ZAWIEJA; Fiscal Year: 2013
    ..Dietary endotoxin readily associates with chylomicrons and are primarily absorbed through the mesenteric lymphatics along with many other gut peptides and hormones, ..
  7. FFA Production From Triglyceride-Rich Lipoproteins
    John M Miles; Fiscal Year: 2013
    ..Lipid energy is transported in the blood in severa forms, including chylomicrons and free fatty acids (FFA)...
  8. Molecular Regulation of LRAT and CYP26 in Lung and Liver
    A Catharine Ross; Fiscal Year: 2012
    ..retinoids to synergize with retinol;(1b) whether the uptake by the lungs of newly absorbed VA contained in chylomicrons is increased in the presence of RA;and (1c) whether inflammation, a concomitant factor in lung immaturity, ..
  9. LPL-Deficient Cats-A Quantitative Model of Gene Delivery
    PHILIP RICHARD VULLIET; Fiscal Year: 2010
    ..LPL-/- cats share the identical mutation and cannot hydrolyze chylomicrons resulting in identical aberrations of their plasma lipid profile (PLP)...
  10. New Avenues in GPIHBP1 Research
    Anne Beigneux; Fiscal Year: 2012
    ..g., heart, muscle, fat) and because GPIHBP1 binds both lipoprotein lipase (LPL) and chylomicrons, we suspect that GPIHBP1 serves as a platform for the metabolic processing of triglyceride-rich lipoproteins...
  11. Genetic Analysis of Proteoglycan-Mediated Lipoprotein Clearance
    Jeffrey D Esko; Fiscal Year: 2013
    ..Hypertriglyceridemia results from the accumulation of triglyceride-rich lipoproteins (TRLs) in the circulation (chylomicrons, very low-density lipoproteins, and their remnants)...
  12. Interaction of Nutrient & Organochlorine Absorption
    Patrick Tso; Fiscal Year: 2010
    ..We demonstrated that labeled hexachlorobenzene (HCB) carried in chylomicrons is cleared from the circulation faster than the labeled fatty acid (FA) as part of the triglyceride (TG)...
  13. EXTRACELLULAR REGULATION OF LIPOPROTEIN LIPASE ACTIVITY
    IRA JAY GOLDBERG; Fiscal Year: 2013
    ..retards adipose tissue development and increases muscle mass;in the heart, lipid uptake pathways for VLDL and chylomicrons differ;DGAT1 deletion increases muscle mass and also dramatically reduces expression of lipid uptake and ..
  14. Phase 2 Study of Orlistat and SLX-4090 for Type I Hyperlipoproteinemia
    Abhimanyu Garg; Fiscal Year: 2012
    ..inhibitor of microsomal triglyceride transport protein (MTP) involved in the assembly and secretion of chylomicrons (SLx-4090), alone and in combination, for reducing serum triglyceride levels in patients with type I ..
  15. Lipogenesis, lipoprotein flux &CVD risk: role of meal composition &frequency
    Jean Marc Schwarz; Fiscal Year: 2013
    ..will do so by measuring th individual contributions of very low density lipoprotein (VLDL;from the liver) and chylomicrons (chylos, from the intestine) to overall postprandial lipoprotein-TG production and clearance in overweight and ..
  16. COPII mediated trafficking of large lipoprotein cargos
    David Melville; Fiscal Year: 2013
    ..An essential step of lipoprotein secretion is COPII-dependent transit from the ER to the Golgi in the form of chylomicrons in the intestine and very low density lipoproteins (VLDL) in the liver...
  17. Exploring Insulin's regulation of subcellular fatty acid metabolism in zebrafish
    Juliana Debrito Carten; Fiscal Year: 2012
    ..they partition into different subcellular compartments, with long and medium chain FAs entering lipid drops and chylomicrons and short chain FAs remaining in more aqueous environments...
  18. The regulation of hepatic lipid metabolism by apolipoprotein AIV
    ALISON BLOOM KOHAN; Fiscal Year: 2013
    ..we hypothesize (1) that apoAIV plays an important physiological role in mediating the efficiency with which chylomicrons are taken up by the peripheral tissues and liver;2) that apoAIV acts in the liver to impact the synthesis and/..
  19. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2004
    DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
  20. DIETARY N-3 FATTY ACIDS: TRANSPORT AND UPTAKE INTO BRAIN
    Gregory Anderson; Fiscal Year: 1993
    ..Intravenous injection of radiolabeled saturated, n-6, and n-3 fatty acids, contained in phospholipids, chylomicrons, and as free fatty acids, will test whether there is a preferred chemical form for "brain-destined" fatty acids...
  21. DIETARY CHOLESTEROL EFFECTS ON PLASMA LIPOPROTEINS
    PHYLLIS MCPHERSON; Fiscal Year: 1990
    ..Retinyl palmitate labelled chylomicrons will be used to determine chylomicron remnant kinetics and attendant changes in the composition of plasma ..
  22. MECHANISM OF APOLIPOPROTEIN B-48 BIOGENESIS
    Lawrence Chan; Fiscal Year: 1993
    ..ApoB-48 is an obligatory component of chylomicrons. In humans, it is synthesized in the small intestine...
  23. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard B Weinberg; Fiscal Year: 2010
    ..by the intestinal enterocytes of mammals during lipid absorption and secreted into lymph on the surface of chylomicrons. Although a broad spectrum of physiologic functions has been proposed for apo A-IV, a preponderance of evidence ..
  24. VITAMIN A TRANSPORT DURING LACTATION
    A Ross; Fiscal Year: 1992
    ..model, we will conduct a series of experiments in which lactating rats will receive an intravenous test dose of chylomicrons that have been labeled in vivo with 3H-retinyl esters...
  25. MPT INHIBITOR IND 50,820 IN FAMILIAL HYPERCHOLESTEROLEM*
    Marina Cuchel; Fiscal Year: 2009
    ..is a protein responsible for transferring lipids onto apolipoprotein B (apo B) in the assembly of intestinal chylomicrons and hepatic very low density lipoprotein (VLDL)...
  26. NUTRITION AND METABOLISM--ABETALIPOPROTEINEMIA
    D Illingworth; Fiscal Year: 1991
    ..composition of breast milk will be conducted to determine how this is influenced by the inherent absence of chylomicrons and whether the predicted abnormal fatty acid composition can be modified by the intravascular infusion of an ..
  27. NEW TRANSGENIC MODELS OF HYPERTRIGLYCERIDEMIA
    Neil Shachter; Fiscal Year: 2001
    The apolipoproteins (apo) C are major constituents of VLDL, HDL and chylomicrons. Of the three apoC's, only apoCII, the activator of lipoprotein lipase (LPL), has a clearly-established role in lipoprotein metabolism...
  28. Irreversible inhibitors of cholesterol esterase
    LORRAINE DECK; Fiscal Year: 2005
    ..that CE functions within the enterocyte to re-esterify cholesterol in the pathway leading to the formation of chylomicrons. It is our hypothesis that inhibition of any of these functions of CE would provide a new approach to the ..
  29. LIPOPROTEIN LIPASE, NUTRITION AND NERVE MYELINATION
    Robert Eckel; Fiscal Year: 2003
    ..enzyme which releases fatty acids and monoacylglyerol from nutrient-dependent triglyceride-rich lipoproteins [chylomicrons and very low density lipoproteins (VLDL)] and regulates the partitioning of these lipid fuels to tissues...
  30. METABOLIC REGULATION OF APOLIPOPROTEIN B MRNA EDITING
    Harold Smith; Fiscal Year: 2003
    ..from the applicant's description): Apolipoprotein B (apoB) is a non-exchangeable structural component of chylomicrons and of very low density (VLDL), intermediate density (IDL), and low density (LDL) lipoprotein particles...
  31. IN VIVO DYNAMIC OF BETA-CAROTENE METABOLISM IN HUMANS
    Andrew Clifford; Fiscal Year: 2006
    Delayed clearance of triacylglycerol-rich lipoprotein particles from intestinal (chylomicrons) and hepatic (VLDL) origins is emerging as a leading risk factor for atherosclerosis, however, it is unclear whether hypertriglyceridemia is a ..
  32. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..vein blood, liver, and bile in wild-type and all seven Cyp1 knockout mouse lines, and the role and mechanism of chylomicrons in delivering BaP to target organs;[b] generate liver- and intestinal epithelium-specific Cyp1a1 conditional ..
  33. CHOLESTEROL-RICH DIET AND PLASMA LIPID TRANSPORT
    Wolfgang Patsch; Fiscal Year: 1991
    ..Our central hypothesis is that cholesterol homeostasis is intimately linked to the catabolism of chylomicrons in that ineffective clearance of chylomicrons fails to inhibit endogenous cholesterol synthesis and hepatic ..
  34. CHOLESTEROL METABOLISM IN ATHEROSCLEROSIS RESISTANCE
    MERRILL OVERTURF; Fiscal Year: 1990
    ..metabolism at major metabolic sites including dietary cholesterol absorption, intestinal transport of chylomicrons, compositional analysis of chylomicrons and chylomicron remnant particles, and bile acid synthesis, secretion ..
  35. INTESTINAL LIPOPROTEINS IN THE NEONATE
    Dennis Black; Fiscal Year: 1991
    ..in plasma very low density Lp (VLDL) and low density Lp (LDL), but both apo B-100 and B-48 are present in lymph chylomicrons (CM) and VLDL, a pattern not found in mature mammals...
  36. EFFECT OF DIETARY LECITHIN ON HDL AND OTHER LIPOPROTEINS
    Donald Small; Fiscal Year: 1980
    ..lipoprotein precursers including lecithin and A-1 are synthesized in the intestine and may enter the lymph on chylomicrons. Lecithin (phosphotidylcholine) is a major component of the surface chylomicrons acting as a major emulsifier ..
  37. The roles of apolipoprotein A-IV structure and lipid affinity in its function
    W Davidson; Fiscal Year: 2009
    ..Upon entry into plasma from the intestinal lymphatics, human apoA-IV rapidly dissociates from chylomicrons and either associates with high density lipoproteins or exists as a significant fraction of lipid-free apoA-IV...
  38. APOB FOLDING & SECRETION--CHARACTERIZING HELPER PROTEINS
    Haya Herscovitz; Fiscal Year: 2000
    ..essential for the assembly and secretion of triglyceride rich lipoproteins (very low density lipoproteins and chylomicrons) and for the receptor-mediated catabolism of low density lipoproteins (LDL), the major carriers of plasma ..
  39. STRUCTURE AND FUNCTION STUDIES ON HEPATIC LIPASE
    MICHAEL KOMAROMY; Fiscal Year: 1992
    ..lipoproteins, thus playing a role in atherogenesis, and metabolism of very low density lipoproteins and chylomicrons. The enzyme level is affected by a number of hormones as well as alcohol and vitamin A...
  40. Regulation of Lipoprotein Lipase by Insulin
    VICTORIA KNUTSON; Fiscal Year: 2003
    ..enzyme in the hydrolysis of serum triglycerides associated with the lipoprotein particles VLDL and chylomicrons. Patients with lowered levels of LPL, as seen in Type 2 diabetes mellitus and insulin resistance exhibit ..
  41. ROLE OF APOLIPOPROTEINS IN HYPERTRIGLYCERIDEMIA
    MOTI KASHYAP; Fiscal Year: 1980
    Triglyceride is transported in plasma mainly by very low density lipoproteins (VLDL) and chylomicrons. VLDL and chylomicron hydrolysis is facilitated by the enzyme extrahepatic lipoprotein lipase...
  42. TRANSLOCATION, ASSEMBLY, AND DEGRADATION OF APOB
    Steven Chuck; Fiscal Year: 2002
    ..liver and intestine only in association with cholesterol and triglycerides as lipoprotein particles (VLDL or chylomicrons)...
  43. STRUCTURE AND FUNCTION OF HEPARIN RELEASABLE LIPASES
    Virgil Brown; Fiscal Year: 1980
    Plasma triglycerides in the form of chylomicrons and very low density lipoproteins (VLDL) are degraded in the extrahepatic tissues (primarily muscle and adipose tissue) by the action of lipoprotein lipase (LPL)...
  44. MEDIUM CHAIN FATS: PHYSIOLOGY & CLINICAL IMPLICATIONS
    SAMI HASHIM; Fiscal Year: 1980
    ..MCT does not form chylomicrons and is not deposited in adipose tissue...
  45. ASSEMBLY OF APOB48 CONTAINING LIPOPROTEINS
    M Hussain; Fiscal Year: 1999
    ..the coordinate induction of triglyceride and apoAIV synthesis results in the assembly and secretion of larger chylomicrons. To examine this hypothesis, we will: 1...
  46. LYMPHATIC DELIVERY OF INTERLEUKIN-2
    LINNAR TENG; Fiscal Year: 1992
    ..Two sandwich complexes are described in detail, one that will allow IL-2 to be transported within chylomicrons and the other within the VLDL compartment of plasma...
  47. INTRACELLULAR TRIGLYCERIDE TRANSPORT AND METABOLISM
    John Wetterau; Fiscal Year: 1990
    ..The properties of MTP suggest that it may play a role in the assembly of the triglyceride-rich lipoproteins, chylomicrons and very low density lipoprotein (VLDL)...
  48. ATHEROGENICITY OF APOB CONTAINING LIPOPROTEINS
    Ira Goldberg; Fiscal Year: 2003
    ..Moreover, the experiments are significant for our understanding of atherosclerosis development and may demonstrate molecular methods to alter apoB retention that could be used in treatment and preventative therapies. ..
  49. Hyperglycemia, Aldose Reducatse & Murine Atherosclerosis
    Ira Goldberg; Fiscal Year: 2005
    ..This is significant because it will provide for a model to study this complication and suggest a therapeutic target for prevention of diabetic macrovascular disease. ..
  50. Postprandial Lipemia and Endothelial Function In ACCORD
    Henry Ginsberg; Fiscal Year: 2004
    ....
  51. REGULATION OF INTESTINAL LIPID TRANSPORT
    CHARLES MANSBACH; Fiscal Year: 2007
    ..that a vesicle, which we have named the pre-chylomicron transport vesicle (PCTV), is the mechanism by which chylomicrons are exported from the ER and go specifically to the intestinal Golgi...
  52. Mentored Clinical Research Scholar Program
    Henry Ginsberg; Fiscal Year: 2006
    ..They believe firmly that this K12 CRS Program will have an immense impact on the future of patient-oriented research in the next decades. [unreadable] [unreadable] [unreadable]..
  53. A Cell Biological Approach to Lipid Absorption.
    Charles M Mansbach; Fiscal Year: 2010
    The rate-limiting step in lipid absorption is the exit of pre-chylomicrons from the endoplasmic reticulum, which occurs by budding the pre-chylomicron transport vesicle from the surface of the endoplasmic reticulum membrane...
  54. Prevention of Diabetes with Nutritional Supplements
    Peter Havel; Fiscal Year: 2007
    ..Further studies to investigate the mechanism(s) of action of the supplements or the supplement combinations that are effective in preventing/delaying diabetes onset of diabetes in this model are proposed. [unreadable] [unreadable]..
  55. Lipoproteins and PEDF in the Vascular Complications of Diabetes
    Timothy J Lyons; Fiscal Year: 2010
    ..This work, which involves ongoing collaboration with two large federally funded prospective studies of Type 1 and of Type 2 diabetes, addresses markers and mechanisms for the chronic vascular complications of diabetes. ..
  56. TEACHING NUTRITION TO PREVENT CARDIOVASCULAR DISEASES
    Francine Welty; Fiscal Year: 2004
    ..This career award will establish Dr. Walker as a leader in medical education in nutrition, his long-term career goal. ..
  57. Siemens Acuson Sequoia Ultrasound Machine
    James Stein; Fiscal Year: 2005
    ..There is significant opportunity for greater collaboration, research productivity, and cost savings if an ultrasound system is made available at the UW Medical School as a shared resource. ..
  58. ANS HYPOGLYCEMIA INDUCED GLUCAGON SECRETION IN DIABETES
    Peter Havel; Fiscal Year: 2001
    ..Collectively, these experiments will lead to greater understanding of the pathophysiology and treatment of impaired hypoglycemic counterregulation in diabetes and the greater use of animal models for this area of investigation. ..
  59. MID-ATLANTIC IN VIVO CELLULAR & MOLECULAR IMAGING CENTER
    Jerry Glickson; Fiscal Year: 2002
    ..The MAMIC will therefore serve as a catalyst and focal point for ongoing cancer research employing state of the art imaging techniques. ..
  60. Effects of early-in-life bladder stimulation on adults
    Alan Randich; Fiscal Year: 2004
    ..Translation to the treatment of IC would be highly probable. ..
  61. NHLBI Bay Area Functional Genomics Consortium
    Stephen Young; Fiscal Year: 2007
    ..A fourth objective is to generate a limited number of genetically modified mice, for the purpose of defining the relevance of specific genes to cardiopulmonary development and disease (Components 4-6). ..