Genomes and Genes
Summary: Any of the lipid-protein complexes in which lipids are transported in the blood. Lipoprotein particles consist of a spherical hydrophobic core of triglycerides or cholesteryl esters surrounded by an amphipathic monolayer of phospholipids, cholesterol, and apolipoproteins. (From Dorland, 27th ed)
Publications195 found, 100 shown here
- The protein moiety of Brucella abortus outer membrane protein 16 is a new bacterial pathogen-associated molecular pattern that activates dendritic cells in vivo, induces a Th1 immune response, and is a promising self-adjuvanting vaccine against systemic aKarina A Pasquevich
Laboratory of Immunogenetics, Clinical Hospital José de San Martín, School of Medicine, University of Buenos Aires, Buenos Aires
J Immunol 184:5200-12. 2010Knowing the inherent stimulatory properties of the lipid moiety of bacterial lipoproteins, we first hypothesized that Brucella abortus outer membrane protein (Omp)16 lipoprotein would be able to elicit a protective immune response without ..
- Prediction of lipoprotein signal peptides in Gram-negative bacteriaAgnieszka S Juncker
Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby 2800, Denmark
Protein Sci 12:1652-62. 2003..The hidden Markov model (HMM) was able to distinguish between lipoproteins (SPaseII-cleaved proteins), SPaseI-cleaved proteins, cytoplasmic proteins, and transmembrane proteins...
- Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and womenBørge G Nordestgaard
Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
JAMA 298:299-308. 2007Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis.
- Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cellsA S Plump
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
Cell 71:343-53. 1992..This marked hypercholesterolemia is primarily due to elevated levels of very low and intermediate density lipoproteins. At 10 weeks of age, apoE-deficient mice have already developed atherosclerotic lesions in the aorta and ..
- Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver diseaseKerry L Donnelly
Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St. Paul, Minnesota, 55108, USA
J Clin Invest 115:1343-51. 2005..These quantitative metabolic data document that both elevated peripheral fatty acids and DNL contribute to the accumulation of hepatic and lipoprotein fat in NAFLD...
- Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosisStephen J Nicholls
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
JAMA 297:499-508. 2007..However, no data exist describing the relationship between statin-induced changes in high-density lipoprotein cholesterol (HDL-C) and disease progression...
- Trends in serum lipids and lipoproteins of adults, 1960-2002Margaret D Carroll
National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
JAMA 294:1773-81. 2005....
- Plasma lipoproteins: genetic influences and clinical implicationsRobert A Hegele
Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, 406 100 Perth Drive, London, Ontario, Canada N6A 5K8
Nat Rev Genet 10:109-21. 2009..growing global public health problem of cardiovascular disease is associated with levels of plasma lipids and lipoproteins. Several experimental strategies have helped us to clarify the genetic architecture of these complex traits, ..
- Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonanceW Timothy Garvey
Division of Endocrinology and Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
Diabetes 52:453-62. 2003..It will be important to study whether NMR lipoprotein subclass parameters can be used to manage risk more effectively and prevent cardiovascular disease in patients with the IRS...
- Apolipoprotein E: far more than a lipid transport proteinR W Mahley
Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California 94141 9100, USA
Annu Rev Genomics Hum Genet 1:507-37. 2000..Functional differences in the apoE isoforms that affect (or did affect) survival before the reproductive years probably account, at least in part, for the allele frequencies of the present day...
- Role of lipids, lipoproteins and vitamins in women with breast cancerG Ray
Department of Biosciences, Jamia Millia Islamia, 110025, New Delhi, India
Clin Biochem 34:71-6. 2001..Lipids, lipoproteins and antioxidative vitamins have been associated with the risk of breast cancer...
- Identification of Francisella tularensis lipoproteins that stimulate the toll-like receptor (TLR) 2/TLR1 heterodimerShalini Thakran
Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Biol Chem 283:3751-60. 2008..Here we report the identification of two Francisella lipoproteins, TUL4 and FTT1103, which activate TLR2...
- Kinetic control of TolC recruitment by multidrug efflux complexesElena B Tikhonova
Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Room 208, Norman, OK 73019, USA
Proc Natl Acad Sci U S A 106:16416-21. 2009..We propose that recruitment of TolC by various MFPs is determined not only by kinetics of MFP-TolC interactions but also by oligomerization kinetics of MFPs and pH...
- Patched regulates Smoothened trafficking using lipoprotein-derived lipidsHelena Khaliullina
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Development 136:4111-21. 2009..Here, we show that Drosophila Ptc recruits internalized lipoproteins to Ptc-positive endosomes and that its sterol-sensing domain regulates trafficking of both lipids and Smo from ..
- The metabolism of triglyceride-rich lipoproteins revisited: new players, new insightGeesje M Dallinga-Thie
Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
Atherosclerosis 211:1-8. 2010..In this review, we will provide an overview of novel data on both peripheral TG hydrolysis and hepatic remnant clearance that will improve our knowledge of plasma triglyceride metabolism...
- Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouseShu Wang
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Atherosclerosis 204:147-55. 2009..These data suggest that lower omega-6:EPA+DHA ratio diets lowered some measures of inflammation and Mphi cholesterol accumulation, which was associated with less aortic lesion formation in LDLr-/- mice...
- Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cellsAkio Kawakami
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Circulation 113:691-700. 2006b>Lipoproteins containing apolipoprotein (apo) CIII predict coronary heart disease and associate with components of the metabolic syndrome. ApoCIII inhibits lipoprotein catabolism in plasma...
- Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapibLaurent Yvan-Charvet
Division of Molecular Medicine, Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
Arterioscler Thromb Vasc Biol 30:1430-8. 2010....
- Effects of high-density lipoproteins on pancreatic beta-cell insulin secretionMichelle A Fryirs
The Heart Research Institute, Sydney, New South Wales, Australia
Arterioscler Thromb Vasc Biol 30:1642-8. 2010..Given the current interest in therapeutic interventions that raise HDLs levels, this study investigates the effects of HDLs on insulin secretion from beta-cells...
- Lipoprotein synthesis in mycobacteriaMandana Rezwan
Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 32, CH 8006 Zurich, Switzerland
Microbiology 153:652-8. 2007b>Lipoproteins are a functionally diverse class of secreted bacterial proteins characterized by an N-terminal lipid moiety. The lipid moiety serves to anchor these proteins to the cell surface...
- Definition of the bacterial N-glycosylation site consensus sequenceMichael Kowarik
Institute of Microbiology, Department of Biology, Swiss Federal Institute of Technology Zurich, , Switzerland
EMBO J 25:1957-66. 2006..Thus, bacterial N-glycosylation site selection is more specific than the eukaryotic equivalent with respect to the polypeptide acceptor sequence...
- ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulationMatthew A Kennedy
Department of Biological Chemistry, CHS 33 257, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
Cell Metab 1:121-31. 2005..Finally, we show that cholesterol efflux to HDL specifically requires ABCG1, whereas efflux to apoA1 requires ABCA1. These studies identify Abcg1 as a key gene involved in both cholesterol efflux to HDL and in tissue lipid homeostasis...
- Assembly and channel opening in a bacterial drug efflux machineVassiliy N Bavro
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
Mol Cell 30:114-21. 2008..We suggest that the assembly of multidrug efflux pumps is accompanied by induced fit of TolC driven mainly by accommodation of the periplasmic component...
- Novel aspects of postprandial lipemia in relation to atherosclerosisA Alipour
Department of Internal Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands
Atheroscler Suppl 9:39-44. 2008..The atherogenic mechanisms of postprandial lipids and lipoproteins can be divided into direct lipoprotein-mediated and indirect effects; the latter, in part, by inducing an ..
- The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferiXiaofeng F Yang
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9048, USA
Proc Natl Acad Sci U S A 100:11001-6. 2003..a two-component sensory transduction system, is a pivotal regulator governing the expression of major membrane lipoproteins such as OspC, DbpA, and Mlp8, as well as many other mammalian infection-associated immunogens of Bb...
- Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trialsJ C LaRosa
Office of the President, State University of New York Health Science Center at Brooklyn, 11203, USA
JAMA 282:2340-6. 1999..Lowering low-density lipoprotein cholesterol (LDL-C) is known to reduce risk of recurrent coronary heart disease in middle-aged men. However, this effect has been uncertain in elderly people and women...
- A detailed molecular belt model for apolipoprotein A-I in discoidal high density lipoproteinJ P Segrest
Department of Medicine, University of Alabama Birmingham Medical Center, Birmingham, Alabama 35294, USA
J Biol Chem 274:31755-8. 1999..The resulting model is an antiparallel arrangement with an alignment matching that of the (nonplanar) crystal structure of lipid-free apoA-I...
- An analytical method for size and shape characterization of blood lipoproteinsDiana Cristina Rambaldi
Department of Chemistry G. Ciamician, Bologna, Italy
Clin Chem 53:2026-9. 2007
- Conformational flexibility in the multidrug efflux system protein AcrAJonathan Mikolosko
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92037, USA
Structure 14:577-87. 2006..Notably, unsuspected conformational flexibility in the alpha-helical hairpin domain of AcrA is observed, which has potential mechanistic significance in coupling between AcrA conformations and TolC channel opening...
- The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposityStéphane Mandard
Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
J Biol Chem 281:934-44. 2006..The composite data suggest that via physical association with plasma lipoproteins, FIAF acts as a powerful signal from fat and other tissues to prevent fat storage and stimulate fat ..
- Remnant lipoproteins and atherogenesisAkio Kawakami
Department of Geriatrics and Vascular Medicine, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima D809, Bunkyo-ku, Tokyo, Japan
J Atheroscler Thromb 12:73-6. 2005..triglyceride (TG) levels are closely related to atherosclerosis, independently of serum levels of high-density lipoproteins (HDL) and low-density lipoproteins (LDL)...
- Effects of ethanol intake on lipoproteins and atherosclerosisEliot A Brinton
Department of Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
Curr Opin Lipidol 21:346-51. 2010..This article reviews published studies regarding effects of ethanol intake on lipoprotein levels and function as they relate to atherosclerosis, with special emphasis on recent publications in the past 2 years...
- AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux ComplexElena B Tikhonova
Department of Chemistry and Biochemistry, University of Oklahoma, Norman, 73019, USA
J Biol Chem 279:32116-24. 2004..We show that antibiotics, the substrates of AcrAB-TolC, stabilize interactions within the complex. However, the formation of the AcrAB-TolC complex does not require an input of energy...
- A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infectionAnn E Jerse
Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Infect Immun 71:5576-82. 2003..However, hormonally regulated factors rather than progesterone itself may be responsible for the more rapid clearance of mtr-deficient gonococci from intact mice...
- Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sexM Cnop
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System (151) and University of Washington, 1660 S. Columbian Way, Seattle, WA 98108, USA
Diabetologia 46:459-69. 2003..investigated the relationships between adiponectin and leptin, body fat distribution, insulin sensitivity and lipoproteins. METHODS: We measured plasma adiponectin, leptin and lipid concentrations, intra-abdominal and subcutaneous fat ..
- Lipoprotein lipase bound to apolipoprotein B lipoproteins accelerates clearance of postprandial lipoproteins in humansChunyu Zheng
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Arterioscler Thromb Vasc Biol 26:891-6. 2006..Experiments in cells and animal models show that lipoprotein lipase (LpL) bound to apolipoprotein (apo)B lipoproteins enhances their uptake by receptor mediated pathways. It is unknown whether this pathway is important in humans...
- Staphylococcus aureus lipoproteins trigger human corneal epithelial innate response through toll-like receptor-2Qiong Li
Kresge Eye Institute Department of Ophthalmology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Microb Pathog 44:426-34. 2008Bacterial lipoproteins (LP) are a family of cell wall components found in a wide variety of bacteria...
- Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver diseaseElisa Fabbrini
Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
Gastroenterology 134:424-31. 2008..The purpose of this study was to evaluate TG metabolism in adipose tissue and liver in NAFLD...
- Identification of immunodominant B- and T-cell combined epitopes in outer membrane lipoproteins LipL32 and LipL21 of Leptospira interrogansXu Ai Lin
Department of Medical Microbiology and Parasitology, School of Medicine, Zhejiang University, Hangzhou 310058, China
Clin Vaccine Immunol 17:778-83. 2010..LipL32 and LipL21 are the conserved outer membrane lipoproteins of L. interrogans and are considered vaccine candidates...
- TAT-pathway-dependent lipoproteins as a niche-based adaptation in prokaryotesHamsanathan Shruthi
Centre for Biotechnology, Anna University, Chennai 600 025, Tamil Nadu, India
J Mol Evol 70:359-70. 2010Bacterial lipoproteins, characterized by the N-terminal N-acyl S-diacylglyceryl Cysteine, are key membrane proteins in bacterial homeostasis...
- Recent insights into factors affecting remnant lipoprotein uptakeKevin Jon Williams
Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
Curr Opin Lipidol 21:218-28. 2010Remnant lipoproteins that persist in the bloodstream after each meal have become increasingly important contributors to atherosclerotic vascular disease, owing to the spread of overnutrition, underexertion, obesity, insulin resistance, ..
- Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitusEric A Schwartz
Department of Endocrinology, Phoenix VA Health Care System, 650 E Indian School Road 111E, Phoenix, AZ 85012 1892, USA
Atherosclerosis 212:217-22. 2010..Therefore, the effect of a single injection of exenatide on postprandial lipids, remnant lipoproteins, and apolipoproteins was studied.
- GPIHBP1 is responsible for the entry of lipoprotein lipase into capillariesBrandon S J Davies
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Cell Metab 12:42-52. 2010The lipolytic processing of triglyceride-rich lipoproteins by lipoprotein lipase (LPL) is the central event in plasma lipid metabolism, providing lipids for storage in adipose tissue and fuel for vital organs such as the heart...
- Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2Michael G Drage
Department of Pathology, Case Western Reserve University University Hospitals Case Medical Center, Cleveland, Ohio, USA
Nat Struct Mol Biol 17:1088-95. 2010..In conclusion, we demonstrate a glycolipid binding function of LprG that enhances recognition of triacylated MTB glycolipids by TLR2 and may affect glycolipid assembly or transport for bacterial cell wall biogenesis...
- Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophagesPreetha Shridas
Graduate Center for Nutritional Sciences, Saha Cardiovascular Research Center, University of Kentucky Medical Center, Lexington 40536 0200, USA
Arterioscler Thromb Vasc Biol 30:2014-21. 2010....
- Lipoproteins of bacterial pathogensA Kovacs-Simon
Room 416, School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, Devon, United Kingdom EX4 4QD
Infect Immun 79:548-61. 2011Bacterial lipoproteins are a set of membrane proteins with many different functions...
- Funnel-like hexameric assembly of the periplasmic adapter protein in the tripartite multidrug efflux pump in gram-negative bacteriaYongbin Xu
Department of Manufacturing Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 609 735, Republic of Korea
J Biol Chem 286:17910-20. 2011....
- Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in miceKristin I Stanford
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0687, USA
J Clin Invest 119:3236-45. 2009..In mice, accumulation of triglyceride-rich lipoproteins can occur if sulfation of heparan sulfate in hepatocytes is diminished, as this alters hepatic lipoprotein ..
- Impact of progressive resistance training on lipids and lipoproteins in adults: another look at a meta-analysis using prediction intervalsGeorge A Kelley
School of Medicine, Department of Community Medicine, West Virginia University, Morgantown, West Virginia 26506 9190, USA
Prev Med 49:473-5. 2009..for a new study is estimated from meta-analytic data, we used the results from our previously published meta-analysis to calculate PIs for changes in lipids and lipoproteins as a result of progressive resistance training (PRT) in adults.
- Atherogenesis and the humoral immune response to modified lipoproteinsGabriel Virella
Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, United States
Atherosclerosis 200:239-46. 2008..There is no conclusive evidence supporting a protective role for IgM antibodies in humans, possibly because autoantibodies to modified lipoproteins are predominantly of the IgG isotype.
- New insights into the molecular actions of plant sterols and stanols in cholesterol metabolismLaura Calpe-Berdiel
Servei de Bioquimica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Atherosclerosis 203:18-31. 2009..This article reviews the progress to date in studying these effects of phytosterols/phytostanols and the molecular mechanisms involved...
- Brucella lipoproteins mimic dendritic cell maturation induced by Brucella abortusAstrid Zwerdling
Instituto de Estudios de la Inmunidad Humoral CONICET, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires U B A, Buenos Aires, Argentina
Microbes Infect 10:1346-54. 2008..These results demonstrate that B. abortus lipoproteins can stimulate DC maturation providing a mechanism by which these bacteria generate a Th1-type immune response.
- Molecular processes that handle -- and mishandle -- dietary lipidsKevin Jon Williams
Division of Endocrinology, Diabetes, and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5005, USA
J Clin Invest 118:3247-59. 2008..These mechanistic insights provide new opportunities to correct dyslipoproteinemia, accelerated atherosclerosis, insulin resistance, and other deadly sequelae of overnutrition and underexertion...
- Trends in plasma lipids, lipoproteins and dyslipidaemias in French adults, 1996-2007Jean Ferrieres
INSERM U558, Department of Epidemiology, Toulouse University Hospital, 31059 Toulouse, France
Arch Cardiovasc Dis 102:293-301. 2009..In France, the reported decrease in cardiovascular death is due partly to improved cardiovascular prevention. The management of dyslipidaemias remains a priority of preventive cardiology...
- Secretion of hepatitis C virus envelope glycoproteins depends on assembly of apolipoprotein B positive lipoproteinsVinca Icard
Universite de Lyon, Lyon, France
PLoS ONE 4:e4233. 2009..has been attributed to an association of the virus with apolipoprotein B (apoB) positive and triglyceride rich lipoproteins (TRL) likely resulting in hybrid lipoproteins known as lipo-viro-particles (LVP) containing the viral envelope ..
- Assembly and transport mechanism of tripartite drug efflux systemsRajeev Misra
Faculty of Cellular and Molecular Biosciences, School of Life Sciences, Arizona State University, Tempe, AZ 85285 4501, USA
Biochim Biophys Acta 1794:817-25. 2009..This new information will be critical in developing inhibitors against MDR pumps to improve the potency of prescribed drugs...
- Contribution of lipoproteins and lipoprotein processing to endocarditis virulence in Streptococcus sanguinisSankar Das
The Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298 0566, USA
J Bacteriol 191:4166-79. 2009Streptococcus sanguinis is an important cause of infective endocarditis. Previous studies have identified lipoproteins as virulence determinants in other streptococcal species...
- A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasomeRaúl Muñoz-Planillo
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 183:3942-8. 2009..and beta-hemolysins alone did not trigger caspase-1 activation, but they did so in the presence of bacterial lipoproteins released by S. aureus. Notably, caspase-1 activation induced by S...
- Sequential mechanism of assembly of multidrug efflux pump AcrAB-TolCElena B Tikhonova
Department of Chemistry and Biochemistry, Stephenson Life Science Research Center, University of Oklahoma, Norman, OK 73019, USA
Chem Biol 18:454-63. 2011..The conformation of the membrane proximal domain of AcrA is critical for the formation of AcrAB-TolC and could be targeted for the development of new inhibitors...
- Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2Niaz Banaiee
Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, NY 10016, USA
J Immunol 176:3019-27. 2006..To determine the relative contribution of lipoproteins to the inhibition of responses to IFN-gamma, we deleted the M...
- Elevated remnant-like particle cholesterol concentration: a characteristic feature of the atherogenic lipoprotein phenotypeT B Twickler
Department of Internal Medicine, Medical Center, Utrecht, The Netherlands
Circulation 109:1918-25. 2004
- Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-gamma-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signalingMeghan E Pennini
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
J Immunol 176:4323-30. 2006..Chromatin remodeling at MHC2TA is a novel target of inhibition by Mtb. These mechanisms may diminish class II MHC expression by infected macrophages, contributing to immune evasion by Mtb...
- Characterization of the plasma lipoproteins and apoproteins of the Erythrocebus patas monkeyR W Mahley
Biochemistry 15:1928-33. 1976Patas monkey lipoproteins were fractionated into four distinct classes by a combination of ultracentrifugation and Geon-Pevikon block electrophoresis and characterized with respect to their chemical and physical properties...
- Phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein B lipoproteinsPaul Rava
Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
J Biol Chem 281:11019-27. 2006..lipid transfer activity, we compared the ability of hMTP and its Drosophila ortholog (dMTP) to assemble apoB lipoproteins and to transfer various lipids...
- Effect of soya protein on serum lipid profile and lipoprotein concentrations in patients undergoing hypercholesterolaemic haemodialysisShu-Tzu Chen
Department of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan
Br J Nutr 95:366-71. 2006....
- Comparison of assessment techniques: plasma lipid and lipoproteins related to the metabolic syndromeBrenda M Davy
Dept of Human Nutrition, Foods and Exercise 0430, Virginia Tech, Blacksburg, VA 24061, USA
Lipids Health Dis 5:3. 2006..was to determine the influence of analytical method on reported concentrations of plasma lipids and lipoproteins, and to determine if there are clinical implications of any potential differences on identification of the ..
- Accelerated lipid absorption in mice overexpressing intestinal SR-BIFlorence Bietrix
INSERM U 563, Centre de Physiopathologie de Toulouse Purpan, Département Lipoprotéines et Médiateurs Lipidiques, IFR30 and Université Paul Sabatier, 31024 Toulouse Cedex 3, France
J Biol Chem 281:7214-9. 2006..Thus, we described for the first time a functional role in vivo for SR-BI in cholesterol but also in triglyceride intestinal absorption...
- Basal and post-methionine serum homocysteine and lipoprotein abnormalities in patients with chronic liver diseaseZ Ben-Ari
Department of Medicine, Rabin Medical Center, Petah Tiqva, Israel
J Investig Med 49:325-9. 2001..For most patients with CLD, factors other than serum homocysteine or Lp(a) are responsible for the reduction in the risk of coronary heart disease. Further studies with larger samples are needed...
- Attenuated corticosterone response to chronic ACTH stimulation in hepatic lipase-deficient mice: evidence for a role for hepatic lipase in adrenal physiologyHELEN L DICHEK
Dept of Pediatrics, Box 356320, Univ of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
Am J Physiol Endocrinol Metab 290:E908-15. 2006Hepatic lipase (HL), a liver-expressed lipolytic enzyme, hydrolyzes triglycerides and phospholipids in lipoproteins and promotes cholesterol delivery through receptor-mediated whole particle and selective cholesterol uptake...
- Meta-analysis of the effects of n-3 polyunsaturated fatty acids on lipoproteins and other emerging lipid cardiovascular risk markers in patients with type 2 diabetesJ Hartweg
Division of Public Health and Primary Health Care, University of Oxford, Old Road Campus, Headington, Oxford, UK
Diabetologia 50:1593-602. 2007..To determine the effects of marine-derived n-3 polyunsaturated fatty acids (PUFA) on established and emerging lipid and lipoprotein cardiovascular risk markers in patients with type 2 diabetes...
- Effects of transdermal estrogen on levels of lipids, lipase activity, and inflammatory markers in men with prostate cancerJonathan Q Purnell
Department of Medicine, Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, OR 97239, USA
J Lipid Res 47:349-55. 2006..Compared with ADT, short-term TDE therapy of prostate cancer improves lipid levels without deterioration of CVD-associated inflammatory markers and may, on longer-term follow-up, improve CVD and mortality rates...
- Human apoA-I expression in CETP transgenic rats leads to lower levels of apoC-I in HDL and to magnification of CETP-mediated lipoprotein changesDavid Masson
Laboratoire de Biochimie des Lipoproteines, INSERM U498, Faculte de Medecine, BP87900, 21079 Dijon Cedex, France
J Lipid Res 47:356-65. 2006..CETP) has a profound effect on neutral lipid transfers between HDLs and apolipoprotein B (apoB)-containing lipoproteins when it is expressed in combination with human apoA-I in HuAI/CETP transgenic (Tg) rodents...
- Anomalous lipoproteins in obese Zucker ratsM Blay
, , Universitat de Barcelona, Av. Diagonal 645, 08028 Barcelona, Spain
Diabetes Obes Metab 3:259-70. 2001..3 +/- 0.2 mg/ml in lean rats [LR] (34% of all lipoproteins) and 8.2 +/- 0.9 mg/ml in the obese rats [OR] (66% of all lipoproteins)...
- Decreased nitric oxide end-products and its relationship with high density lipoprotein and oxidative stress in people with type 2 diabetes without complicationsB Vanizor
Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey
Diabetes Res Clin Pract 54:33-9. 2001..In the present study the aim was to determine the relationships between serum lipids, lipoproteins, erythrocyte malondialdehyde (eMDA), as a marker for oxidative stress, and serum nitrite and nitrate levels, as ..
- Characterisation of the lipoprotein structure in the St. Thomas' Mixed Hyperlipidaemic (SMHL) rabbitBaukje de Roos
Department of Vascular Biochemistry, Division of Cardiovascular and Medical Sciences, Glasgow, UK
Atherosclerosis 181:63-8. 2005..the hyperlipidaemia is caused primarily by an increased production rate of apolipoprotein B (apoB)--containing lipoproteins-and compared them with those in the Watanabe Heritable Hyperlipidaemic (WHHL) rabbit, in which hyperlipidaemia ..
- Regulation of plasma triglycerides in insulin resistance and diabetesHenry N Ginsberg
College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Arch Med Res 36:232-40. 2005Increased plasma levels of triglycerides (TG) in very low density lipoproteins (VLDL) are not only common characteristics of the dyslipidemia associated with insulin resistance and type 2 diabetes mellitus (T2DM) but are the central ..
- Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions: The Atherosclerosis Risk in Communities (ARIC) StudyA R Sharrett
Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
Circulation 104:1108-13. 2001..CONCLUSIONS: Optimal LDL-C values are <100 mg/dL in both women and men. LDL-C, HDL-C, TG, and Lp(a), without additional apolipoproteins or lipid subfractions, provide substantial CHD prediction, with much higher RR in women than men...
- Apple procyanidins decrease cholesterol esterification and lipoprotein secretion in Caco-2/TC7 enterocytesRomain Vidal
, , 75006 Paris, France
J Lipid Res 46:258-68. 2005..epithelium that faces dietary compounds, and it contributes to lipid homeostasis by secreting triglyceride-rich lipoproteins during the postprandial state...
- Insulin resistance is independently associated with postprandial alterations of triglyceride-rich lipoproteins in type 2 diabetes mellitusGiovanni Annuzzi
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
Arterioscler Thromb Vasc Biol 24:2397-402. 2004....
- Influence of liver cancer on lipid and lipoprotein metabolismJingting Jiang
Section of Clinical Chemistry and Pharmacology, Institute of Laboratory Medicine, Lund University, S 221 85 Lund, Sweden
Lipids Health Dis 5:4. 2006Liver plays a key role in the metabolism of plasma apolipoproteins, endogenous lipids and lipoproteins. Hepatocellular carcinoma (HCC) is one of the most common fatal malignant tumors in China and in other Southeast Asian countries...
- Glucosyl hesperidin lowers serum triglyceride level in hypertriglyceridemic subjects through the improvement of very low-density lipoprotein metabolic abnormalityYoshikatsu Miwa
Hayashibara Biochemical Laboratories, Inc, 1-2-3 Shimoishii, Okayama 700-0907, Japan
J Nutr Sci Vitaminol (Tokyo) 51:460-70. 2005..Moreover, polyacrylamide gel electrophoresis analysis of serum lipoproteins revealed that the very low-density lipoprotein (VLDL)/low-density lipoprotein (LDL) ratio and LDL migration ..
- Decreased lipoprotein clearance is responsible for increased cholesterol in LDL receptor knockout mice with streptozotocin-induced diabetesIra J Goldberg
Division of Preventive Medicine, Columbia University, New York, New York 10032, USA
Diabetes 57:1674-82. 2008..Patients with diabetes often have dyslipidemia and increased postprandial lipidmia. Induction of diabetes in LDL receptor (Ldlr(-/-)) knockout mice also leads to marked dyslipidemia. The reasons for this are unclear...
- Expression of human apolipoprotein A-II in apolipoprotein E-deficient mice induces features of familial combined hyperlipidemiaJ C Escolà-Gil
Servei de Bioquímica de l Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain
J Lipid Res 41:1328-38. 2000..lipoprotein (HDL) of unknown function, in transgenic mice produced increased concentration of apoB-containing lipoproteins and decreased HDL...
- Dietary fat modulates serum paraoxonase 1 activity in ratsB J Kudchodkar
Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, USA
J Nutr 130:2427-33. 2000..Serum lipids and lipid components of lipoproteins were also determined. Serum PON1 activity [micromol/(L.min)] was significantly (P: < 0...
- Nine months aerobic fitness induced changes on blood lipids and lipoproteins in untrained subjects versus controlsSusanne Ring Dimitriou
Department of Sport Science and Kinesiology, University of Salzburg, Salzburg, Austria
Eur J Appl Physiol 99:291-9. 2007..04) compared to the control group (NS). In 9 months, E achieved 24% increase in VO(2peak) and 18% reduction in Apo B, denoting the impact of cardiovascular fitness on cardiovascular risk...
- Hypolipidaemic effect of chemically different mucilages in rats: a comparative studyPuthenpura T Boban
Department of Biochemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram, Kerala 695 581, India
Br J Nutr 96:1021-9. 2006..from three different sources were administered to experimental animals and the metabolism of lipids and lipoproteins was studied...
- Vegetable oils affect the composition of lipoproteins in sea bream (Sparus aurata)María José Caballero
Department of Comparative Pathology, Trasmontana, S N, 35416 Arucas, Las Palmas de Gran Canaria, Canary Islands, Spain
Br J Nutr 96:830-9. 2006..VLDL was the fraction more affected by dietary fatty acid, followed by LDL and HDL. The n-3 highly unsaturated fatty acid content increased in the order VLDL less than LDL and less than HDL, regardless of dietary vegetable oils...
- Effect of dialysis type on serum lipids, apolipoproteins, and lipoproteinsMehmet Kanbay
Department of Nephrology, Fatih University, Faculty of Medicine, Turkey
Ren Fail 28:567-71. 2006..The aim of this study was to determine the effect of dialysis type on serum lipid levels...
- Protective effect of rutin on lipids, lipoproteins, lipid metabolizing enzymes and glycoproteins in streptozotocin-induced diabetic ratsP Stanely Mainzen Prince
Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608 002, Tamilnadu, India
J Pharm Pharmacol 58:1373-83. 2006The protective role of rutin on lipids, lipoproteins, lipid metabolizing enzymes and glycoproteins in streptozotocin-induced diabetic rats has been studied...
- A 1,3-diacylglycerol-rich oil induces less atherosclerosis and lowers plasma cholesterol in diabetic apoE-deficient miceAkihiko Fujii
Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi 312 3497, Japan
Atherosclerosis 193:55-61. 2007....
- The effects of adrenocorticotrophic hormone and an equivalent dose of cortisol on the serum concentrations of lipids, lipoproteins, and apolipoproteinsAnna-Lena Berg
Department of Nephrology, University Hospital, Lund 221 85, Sweden
Metabolism 55:1083-7. 2006..The statistical workup confirmed that only ACTH had a lowering effect on the apo B-containing lipoproteins. In contrast, the results indicated conformity between the treatment groups with respect to increases in the ..
- Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the Framingham Heart StudyChao Qiang Lai
Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Circulation 113:2062-70. 2006..Apolipoprotein A5 gene (APOA5) variation is associated with plasma triglycerides (TGs). However, little is known about whether dietary fat modulates this association...
- Insulin resistance, dietary cholesterol, and cholesterol concentration in postmenopausal womenG M Reaven
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
Metabolism 50:594-7. 2001....
- The expression of apolipoprotein B epitopes is normal in LDL of diabetic and end-stage renal disease patientsS Braschi
Endocrinology Division, Medicine Department, University of Ottawa, Ottawa Hospital, Riverside Campus, 1967 Riverside Drive, Ottawa, ON, K1H 7W9, Canada
Diabetologia 49:1394-401. 2006..The aim of this work was to determine if similar immunological changes are observed in vivo in LDLs of diabetic and end-stage renal disease (ESRD) patients...
- Effects of a monthly injectable steroidal contraceptive, Mesigyna, on menstrual pattern, lipoproteins, and coagulation parametersM Bulent Tiras
Gazi University School of Medicine; Dept. of Obstetrics and Gynecology, Ankara, Turkey
Contraception 63:151-3. 2001..study was to determine the effects of a once-monthly injectable contraceptive (Mesigyna) on menstrual pattern, lipoproteins, and coagulation parameters...
- Hepatocyte damage induced by carbon tetrachloride: inhibited lipoprotein secretion and changed lipoprotein compositionM Boll
Institute of Toxicology, GSF National Research Center for Environment and Health, , Neuherberg, Bundesrepublik Deutschland
Z Naturforsch C 56:283-90. 2001..1) CCl4 decreased secretion of very low density lipoproteins (VLDL) by about 85%, while high density lipoprotein (HDL) secretion was less affected (about 40%)...
- Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemiaKazuhiko Namekata
National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashi 4 1 1, Kodaira, Tokyo 187 8551, Japan
J Biol Chem 279:52961-9. 2004..Moreover, serum cholesterol/triglyceride distribution in lipoprotein fractions was altered in CBS(-/-) mice. These results suggest that hepatic steatosis in CBS(-/-) mice is caused by or associated with abnormal lipid metabolism...
- Factors associated with plasma lipids and lipoproteins in type 1 diabetes mellitus: the EURODIAB IDDM Complications StudyB Idzior-Walus
Department of Metabolic Diseases, College of Medicine, Jagiellonian University, Krakow, Poland
Diabet Med 18:786-96. 2001..CONCLUSION: The results of this study indicate that lipid levels in Type 1 diabetic patients are strongly influenced by smoking habit and central obesity in a way that is characteristic of the insulin resistance syndrome...
- Effects of atorvastatin on triglyceride-rich lipoproteins, low-density lipoprotein subclass, and C-reactive protein in hemodialysis patientsAyako Ikejiri
First Department of Internal Medicine, Showa University School of Medicine, Tokkyo, Japan
Metabolism 53:1113-7. 2004..reduced cholesterol in CM, light VLDL, and dense VLDL without consistently affecting triglyceride (TG) in these lipoproteins. Atorvastatin similarly reduced both light and dense LDL-apo B by 38%...
- [Blood lipids and lipoproteins in acute organophosphorus insecticide poisoning patients]Hai-yin Leu
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 21:225. 2003
- Phenotype-dependent and -independent actions of rosuvastatin on atherogenic lipoprotein subfractions in hyperlipidaemiaMuriel J Caslake
Department of Pathological Biochemistry, Glasgow Royal Infirmary University NHS Trust, 4th Floor Queen Elizabeth Building, 10 Alexandra Parade, Glasgow G31 2ER, UK
Atherosclerosis 171:245-53. 2003..Rosuvastatin therefore, in addition to lowering LDL and apoB-concentrations, largely corrected the TG and LDL abnormalities in subjects who had the propensity to develop the atherogenic lipoprotein phenotype...
- Avoiding toxicity associated with MTP ablationM Mahmood Hussain; Fiscal Year: 2010High plasma lipids and lipoproteins are risk factors for various cardiovascular and metabolic disorders...
- Apo E mimetics reduce cholesterol and improve HDL functionG M Anantharamaiah; Fiscal Year: 2010..This proposal deals with ways of incorporating properties of lowering plasma apolipoprotein B- containing lipoproteins with properties of improving HDL function...
- BONE MARROW TRANSPLANTION AND ATHEROSCLEROSISMacRae Linton; Fiscal Year: 1999..The majority of apoE in the plasma lipoproteins is of hepatic origin, and the relative contribution of extrahepatic apoE to the metabolism of the plasma ..
- Mechanisms of ethanol-induced neurodevelopmental effectsMarina Guizzetti; Fiscal Year: 2009..brain, cholesterol is mostly produced endogenously, and its homeostasis is regulated by endogenously produced lipoproteins and cholesterol transporters...
- Mechanisms of ethanol-induced neurodevelopmental effectsMarina Guizzetti; Fiscal Year: 2010..brain, cholesterol is mostly produced endogenously, and its homeostasis is regulated by endogenously produced lipoproteins and cholesterol transporters...
- Role of Genes in Exceptional Longevity in HumansNir Barzilai; Fiscal Year: 2007..In addition, the Administrative Core is charged with maintaining relationships and contact with enrolled subjects, which is critical to the success of the longitudinal study design. ..
- A novel peroxidase in vascular endothelium and the development of atherosclerosisGuangjie Cheng; Fiscal Year: 2010..Aim #2 will investigate the oxidative modification of lipoproteins and lipids by VPO. The ability of purified VPO to oxidize LDL lipoprotein and lipid will be emphasized...
- APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISMLawrence Chan; Fiscal Year: 2004DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
- Structural Thermodynamics of Human Apolipoprotein C-1Olga Gursky; Fiscal Year: 2003..determine in molecular detail the energetic-structure-function relationship in exchangeable apolipoproteins and lipoproteins, thereby providing an insight into molecular mechanisms of lipoprotein action in the pathogenesis of ..
- Endoplasmic reticulum stress and foam cell formationZhongmao Guo; Fiscal Year: 2010..Similarly, ApoE-deficient (ApoE-/-) mice elevate plasma ApoB48-carrying lipoproteins and develop atherosclerosis in a manner that resembles the human disease...
- Structural Thermodynamics of Human Apolipoprotein C-1Olga Gursky; Fiscal Year: 2007..determine in molecular detail the energetic-structure-function relationship in exchangeable apolipoproteins and lipoproteins, thereby providing an insight into molecular mechanisms of lipoprotein action in the pathogenesis of ..
- Structural Thermodynamics of Human Apolipoprotein C-1Olga Gursky; Fiscal Year: 2006..determine in molecular detail the energetic-structure-function relationship in exchangeable apolipoproteins and lipoproteins, thereby providing an insight into molecular mechanisms of lipoprotein action in the pathogenesis of ..
- Pathogenesis of Lyme Borreliosis in the Rhesus MonkeyMARIO PHILIPP; Fiscal Year: 2007..The secondary hypothesis is that spirochetal lipoproteins can induce, in part or in toto, the inflammatory effects of B. burgdorferi...
- Endoplasmic reticulum stress and foam cell formationZhongmao Guo; Fiscal Year: 2009..Similarly, ApoE-deficient (ApoE-/-) mice elevate plasma ApoB48-carrying lipoproteins and develop atherosclerosis in a manner that resembles the human disease...
- PROTEASE INHIBITOR RELATED DYSLIPIDEMIAChristine Wanke; Fiscal Year: 2004..in the constantly fed state and deuterated leucine, the secretion and catabolism of apoB-48 and apoB-100 within lipoproteins will be determined by GC/MS analysis and multicompartmental modeling in the presence or absence of protease ..
- Nanoparticle Brain Delivery of Iron Chelators for ADGang Liu; Fiscal Year: 2007..will be determined by the 2-dimensional gel analysis, and indicate the capabilities of the systems to mimic lipoproteins. Kinetic studies of the particle delivery systems bi-directionally across Brain Blood Barrier (BBB) will be ..
- Nanoparticle Brain Delivery of Iron Chelators for ADGang Liu; Fiscal Year: 2010..will be determined by the 2-dimensional gel analysis, and indicate the capabilities of the systems to mimic lipoproteins. Kinetic studies of the particle delivery systems bi-directionally across Brain Blood Barrier (BBB) will be ..
- Nanoparticle Brain Delivery of Iron Chelators for ADGang Liu; Fiscal Year: 2009..will be determined by the 2-dimensional gel analysis, and indicate the capabilities of the systems to mimic lipoproteins. Kinetic studies of the particle delivery systems bi-directionally across Brain Blood Barrier (BBB) will be ..
- DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISKERNST SCHAEFER; Fiscal Year: 2003..Obesity increases CHD risk by adversely affecting glucose, lipoproteins, and blood pressure...
- Pharmacogenetics of the Statin ResponseERNST SCHAEFER; Fiscal Year: 2006..These results can be used to formulate guidelines for identifying elderly subjects for statin treatment to prevent future CHD. ..
- ASSEMBLY PATHWAY OF VLDL--A THREE STEP PROCESSLARRY SWIFT; Fiscal Year: 2001..Two steps occur in the rough endoplasmic reticulum (ER), producing triglyceride-rich lipoproteins. The third step involves addition of triglyceride and phospholipid to the maturing particle and occurs as the ..
- Quantitation of Tocopherol Metabolism in HumansAndrew Clifford; Fiscal Year: 2009..The null hypothesis is that EHT-a-TOC eliminated through "reverse cholesterol transfer." Plasma lipoproteins play key roles in delivering RRR-a-TOC to and from EHT...
- Quantitation of Tocopherol Metabolism in HumansANDREW JOSEPH CLIFFORD; Fiscal Year: 2010..The null hypothesis is that EHT-a-TOC eliminated through "reverse cholesterol transfer." Plasma lipoproteins play key roles in delivering RRR-a-TOC to and from EHT...
- ATHEROSCLEROSIS AND PERIPHERAL APOPROTEIN E SYNTHESISDavid Williams; Fiscal Year: 1993..The plasma concentrations of these lipoproteins are important factors in the development of atherosclerotic heart disease.
- ATHEROSCLEROSIS AND PERIPHERAL APOPROTEIN E SYNTHESISDavid Williams; Fiscal Year: 1999..These studies are designed to evaluate the importance of localized apoE expression on tissue cholesterol metabolism and steroidogenesis in normal adrenocortical cells in vivo and in culture. ..
- INTESTINAL LIPOPROTEINS IN THE NEONATEDennis Black; Fiscal Year: 2007..the following specific hypotheses: a) the enhancement of lipid secretion is due to increased size of secreted lipoproteins, and the particles have a normal complement of other apolipoproteins; b) absorbed fatty acid type (chain length ..
- Macrophage-lipoprotein interactionsFrederick R Maxfield; Fiscal Year: 2010Atherosclerosis results in part from the accumulation of lipoproteins in the arterial wall, recruitment of monocytes/macrophages to the region, and formation of lipid-laden macrophages, known as foam cells...
- LIPID AND LIPOPROTEIN METABOLISM IN INSECTSMichael Wells; Fiscal Year: 1993..Whereas vertebrates rely on a battery of lipoproteins to effect lipid transport, insects use primarily a single type of lipoprotein, LIPOPHORIN, for lipid transport...
- GHIHBP1 and the Metabolism of Triglyceride-Rich LipoproteinsStephen Young; Fiscal Year: 2009..we have made a stunning observation-that GPIHBP1 plays a major role in the metabolism of triglyceride-rich lipoproteins in the plasma...
- GHIHBP1 and the Metabolism of Triglyceride-Rich LipoproteinsStephen Young; Fiscal Year: 2007..we have made a stunning observation-that GPIHBP1 plays a major role in the metabolism of triglyceride-rich lipoproteins in the plasma...