lipoproteins

Summary

Summary: Any of the lipid-protein complexes in which lipids are transported in the blood. Lipoprotein particles consist of a spherical hydrophobic core of triglycerides or cholesteryl esters surrounded by an amphipathic monolayer of phospholipids, cholesterol, and apolipoproteins. (From Dorland, 27th ed)

Top Publications

  1. doi The protein moiety of Brucella abortus outer membrane protein 16 is a new bacterial pathogen-associated molecular pattern that activates dendritic cells in vivo, induces a Th1 immune response, and is a promising self-adjuvanting vaccine against systemic a
    Karina A Pasquevich
    Laboratory of Immunogenetics, Clinical Hospital José de San Martín, School of Medicine, University of Buenos Aires, Buenos Aires
    J Immunol 184:5200-12. 2010
  2. pmc Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    Kerry L Donnelly
    Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St Paul, Minnesota, 55108, USA
    J Clin Invest 115:1343-51. 2005
  3. ncbi Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex
    M Cnop
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151 and University of Washington, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetologia 46:459-69. 2003
  4. ncbi Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    A S Plump
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
    Cell 71:343-53. 1992
  5. ncbi Effects of the amount and intensity of exercise on plasma lipoproteins
    William E Kraus
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 347:1483-92. 2002
  6. pmc Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management
    M John Chapman
    European Atherosclerosis Society, INSERM UMR S939, Pitie Salpetriere University Hospital, Paris 75651, France
    Eur Heart J 32:1345-61. 2011
  7. pmc Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 117:3900-8. 2007
  8. pmc Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion
    Liqing Yu
    McDermott Center for Human Growth and Development and Departments of Molecular Genetics and Biochemistry, The Howard Hughes Medical Institute and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 99:16237-42. 2002
  9. pmc Prediction of lipoprotein signal peptides in Gram-negative bacteria
    Agnieszka S Juncker
    Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby 2800, Denmark
    Protein Sci 12:1652-62. 2003
  10. pmc Echinococcus granulosus antigen B impairs human dendritic cell differentiation and polarizes immature dendritic cell maturation towards a Th2 cell response
    Rachele Riganò
    Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Infect Immun 75:1667-78. 2007

Detail Information

Publications246 found, 100 shown here

  1. doi The protein moiety of Brucella abortus outer membrane protein 16 is a new bacterial pathogen-associated molecular pattern that activates dendritic cells in vivo, induces a Th1 immune response, and is a promising self-adjuvanting vaccine against systemic a
    Karina A Pasquevich
    Laboratory of Immunogenetics, Clinical Hospital José de San Martín, School of Medicine, University of Buenos Aires, Buenos Aires
    J Immunol 184:5200-12. 2010
    Knowing the inherent stimulatory properties of the lipid moiety of bacterial lipoproteins, we first hypothesized that Brucella abortus outer membrane protein (Omp)16 lipoprotein would be able to elicit a protective immune response without ..
  2. pmc Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    Kerry L Donnelly
    Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St Paul, Minnesota, 55108, USA
    J Clin Invest 115:1343-51. 2005
    ..These quantitative metabolic data document that both elevated peripheral fatty acids and DNL contribute to the accumulation of hepatic and lipoprotein fat in NAFLD...
  3. ncbi Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex
    M Cnop
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151 and University of Washington, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetologia 46:459-69. 2003
    ..We investigated the relationships between adiponectin and leptin, body fat distribution, insulin sensitivity and lipoproteins.
  4. ncbi Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    A S Plump
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
    Cell 71:343-53. 1992
    ..This marked hypercholesterolemia is primarily due to elevated levels of very low and intermediate density lipoproteins. At 10 weeks of age, apoE-deficient mice have already developed atherosclerotic lesions in the aorta and ..
  5. ncbi Effects of the amount and intensity of exercise on plasma lipoproteins
    William E Kraus
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 347:1483-92. 2002
    ..However, the amount of exercise training required for optimal benefit is unknown. In a prospective, randomized study, we investigated the effects of the amount and intensity of exercise on lipoproteins.
  6. pmc Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management
    M John Chapman
    European Atherosclerosis Society, INSERM UMR S939, Pitie Salpetriere University Hospital, Paris 75651, France
    Eur Heart J 32:1345-61. 2011
    ..This paper aims (i) to critically appraise evidence for elevated levels of triglyceride-rich lipoproteins (TRLs) and low levels of high-density lipoprotein cholesterol (HDL-C) as cardiovascular risk factors, and (ii) ..
  7. pmc Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 117:3900-8. 2007
    ..These results suggest that the combined effects of ABCA1 and ABCG1 in mediating macrophage sterol efflux are central to the antiatherogenic properties of HDL...
  8. pmc Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion
    Liqing Yu
    McDermott Center for Human Growth and Development and Departments of Molecular Genetics and Biochemistry, The Howard Hughes Medical Institute and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 99:16237-42. 2002
    ....
  9. pmc Prediction of lipoprotein signal peptides in Gram-negative bacteria
    Agnieszka S Juncker
    Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby 2800, Denmark
    Protein Sci 12:1652-62. 2003
    ..The hidden Markov model (HMM) was able to distinguish between lipoproteins (SPaseII-cleaved proteins), SPaseI-cleaved proteins, cytoplasmic proteins, and transmembrane proteins...
  10. pmc Echinococcus granulosus antigen B impairs human dendritic cell differentiation and polarizes immature dendritic cell maturation towards a Th2 cell response
    Rachele Riganò
    Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Infect Immun 75:1667-78. 2007
    ..granulosus-stimulated DC maturation. These results suggest that E. granulosus escapes host immunosurveillance in two ways: by interfering with monocyte differentiation and by modulating DC maturation...
  11. ncbi Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    JAMA 298:299-308. 2007
    Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis.
  12. ncbi Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli
    Tao Wu
    Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
    Cell 121:235-45. 2005
    ..These genetic interactions suggest a role for YfgL, one of the lipoprotein components of the protein assembly complex, in a homeostatic control mechanism that coordinates the overall OM assembly process...
  13. pmc Host defenses against Staphylococcus aureus infection require recognition of bacterial lipoproteins
    Juliane Bubeck Wardenburg
    Department of Microbiology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 103:13831-6. 2006
    ..aureus variants lacking lipoproteins escape immune recognition and cause lethal infections with disseminated abscess formation, failing to elicit an ..
  14. pmc Lipoproteins of bacterial pathogens
    A Kovacs-Simon
    Room 416, School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, Devon, United Kingdom EX4 4QD
    Infect Immun 79:548-61. 2011
    Bacterial lipoproteins are a set of membrane proteins with many different functions...
  15. pmc ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Science 328:1689-93. 2010
    ..The findings indicate that ABCA1, ABCG1, and HDL inhibit the proliferation of hematopoietic stem and multipotential progenitor cells and connect expansion of these populations with leukocytosis and accelerated atherosclerosis...
  16. doi Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity
    Alejandro Gallardo-Soler
    Departamento de Bioquimica y Biologia Molecular y Genetica, Universidad de Extremadura Avenida de la Universidad s n, 10071 Caceres, Spain
    Mol Endocrinol 22:1394-402. 2008
    ..The uptake of modified lipoproteins is an important early event in the development of atherosclerosis...
  17. doi High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism
    Pasi Soininen
    NMR Metabonomics Laboratory, Laboratory of Chemistry, Department of Biosciences, University of Kuopio, Kuopio, Finland
    Analyst 134:1781-5. 2009
    ..In contradiction to single 'biomarkers', the application of this holistic NMR approach and the integrated computational methods provides a data-driven systems biology approach to biomedical research...
  18. ncbi Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis
    Stephen J Nicholls
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JAMA 297:499-508. 2007
    ..However, no data exist describing the relationship between statin-induced changes in high-density lipoprotein cholesterol (HDL-C) and disease progression...
  19. pmc RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins
    Antje Blumenthal
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    Cell Host Microbe 5:35-46. 2009
    ..LPS recognition and that RP105 positively regulates macrophage responses to Mycobacterium tuberculosis (Mtb) lipoproteins. Mtb-infected RP105(-/-) mice exhibited impaired proinflammatory cytokine responses associated with enhanced ..
  20. ncbi Unique lipoprotein phenotype and genotype associated with exceptional longevity
    Nir Barzilai
    Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, New York, NY 10461, USA
    JAMA 290:2030-40. 2003
    ..Individuals with exceptional longevity have a lower incidence and/or significant delay in the onset of age-related disease, and their family members may inherit biological factors that modulate aging processes and disease susceptibility...
  21. ncbi Non-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in men
    Tobias Pischon
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Circulation 112:3375-83. 2005
    Apolipoprotein B (apoB) plasma levels reflect the concentration of proatherogenic lipoproteins very low-density lipoprotein and low-density lipoprotein (LDL), whereas non-high-density lipoprotein cholesterol (non-HDL-C) levels reflect the ..
  22. ncbi ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation
    Matthew A Kennedy
    Department of Biological Chemistry, CHS 33 257, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    Cell Metab 1:121-31. 2005
    ..Finally, we show that cholesterol efflux to HDL specifically requires ABCG1, whereas efflux to apoA1 requires ABCA1. These studies identify Abcg1 as a key gene involved in both cholesterol efflux to HDL and in tissue lipid homeostasis...
  23. pmc Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-β-1,6-N-acetylglucosamine
    Rebekah Henry
    Department of Microbiology, Monash University, Clayton, Australia
    Antimicrob Agents Chemother 56:59-69. 2012
    ..Taken together, these data show that, in response to total LPS loss, A. baumannii alters the expression of critical transport and biosynthesis systems associated with modulating the composition and structure of the bacterial surface...
  24. ncbi ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion
    Gregory A Graf
    McDermott Center for Human Growth and Development and Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Biol Chem 278:48275-82. 2003
    ..Finally, adenoviral expression of G2 in the presence or absence of G5 or G8 failed to promote sterol excretion into bile. These experiments indicate that G5 and G8 function as obligate heterodimers to promote sterol excretion into bile...
  25. doi Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study
    Matthew J McQueen
    Population Health Research Institute and McMaster University, Hamilton, ON, Canada
    Lancet 372:224-33. 2008
    Whether lipoproteins are better markers than lipids and lipoproteins for coronary heart disease is widely debated. Our aim was to compare the apolipoproteins and cholesterol as indices for risk of acute myocardial infarction.
  26. ncbi Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters
    Agnes M Rimando
    Natural Products Utilization Research Unit, ARS, U S Department of Agriculture, Mississippi 38677, USA
    J Agric Food Chem 53:3403-7. 2005
    ..In vivo studies demonstrate that pterostilbene possesses lipid and glucose lowering effects...
  27. ncbi Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
    H D Brightbill
    Department of Microbiology and Immunology, Howard Hughes Medical Institute, University of California Los Angeles School of Medicine, Los Anges, CA 90095, USA
    Science 285:732-6. 1999
    ..Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like ..
  28. pmc GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 12:42-52. 2010
    The lipolytic processing of triglyceride-rich lipoproteins by lipoprotein lipase (LPL) is the central event in plasma lipid metabolism, providing lipids for storage in adipose tissue and fuel for vital organs such as the heart...
  29. doi Plasma lipoproteins: genetic influences and clinical implications
    Robert A Hegele
    Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, 406 100 Perth Drive, London, Ontario, Canada N6A 5K8
    Nat Rev Genet 10:109-21. 2009
    ..growing global public health problem of cardiovascular disease is associated with levels of plasma lipids and lipoproteins. Several experimental strategies have helped us to clarify the genetic architecture of these complex traits, ..
  30. ncbi The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens
    Troy Bankhead
    Department of Biochemistry, University of Calgary, Calgary, Alberta T2N 4 N1, Canada
    Mol Microbiol 65:1547-58. 2007
    ..Data are also presented that cast doubt on an immune evasion mechanism whereby VlsE directly masks other surface antigens similar to what has been observed for several other pathogens that undergo recombinational antigenic variation...
  31. pmc Staphylococcus aureus deficient in lipidation of prelipoproteins is attenuated in growth and immune activation
    Hartmut Stoll
    Mikrobielle Genetik, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Infect Immun 73:2411-23. 2005
    ..In the wild type, the majority of [14C]palmitate-labeled lipoproteins were located in the membrane fraction, although some lipoproteins were also present on the cell surface and in ..
  32. doi Lipoprotein sorting in bacteria
    Suguru Okuda
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Microbiol 65:239-59. 2011
    Bacterial lipoproteins are synthesized as precursors in the cytoplasm and processed into mature forms on the cytoplasmic membrane. A lipid moiety attached to the N terminus anchors these proteins to the membrane surface...
  33. doi Possible contributions of lipoproteins and cholesterol to the pathogenesis of diabetes mellitus type 2
    Arnold von Eckardstein
    Institute of Clinical Chemistry, University and University Hospital Zurich, Switzerland
    Curr Opin Lipidol 22:26-32. 2011
    ..We discuss the recent findings on the effects of lipoproteins and cholesterol on the function and survival of pancreatic β-cells as well as on obesity and insulin ..
  34. ncbi Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta
    Joyce J Repa
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    J Biol Chem 277:18793-800. 2002
    ..The addition of ABCG5 and ABCG8 to the growing list of LXR target genes further supports the notion that LXRs serve as sterol sensors to coordinately regulate sterol catabolism, storage, efflux, and elimination...
  35. doi Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: a comparison of older with young men
    N Karaouzene
    Department of Molecular and Cellular Biology, Faculty of Sciences, University Abou Bekr Belkaid, Tlemcen, Algeria
    Nutr Metab Cardiovasc Dis 21:792-9. 2011
    In this study, plasma lipids, lipoproteins and markers of oxidant/antioxidant status were investigated in young (n = 45) and older (n = 40) obese men and compared to those in young (n = 65) and older (n = 55) normal weight controls...
  36. pmc The Echinococcus granulosus antigen B gene family comprises at least 10 unique genes in five subclasses which are differentially expressed
    Wenbao Zhang
    Molecular Parasitology Laboratory, Infectious Diseases Division, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS Negl Trop Dis 4:e784. 2010
    ..It is generally accepted that EgAgB is comprised of a gene family of five subfamilies which are highly polymorphic, but the actual number of genes present is unknown...
  37. doi Effects of ethanol intake on lipoproteins and atherosclerosis
    Eliot A Brinton
    Department of Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Curr Opin Lipidol 21:346-51. 2010
    ..This article reviews published studies regarding effects of ethanol intake on lipoprotein levels and function as they relate to atherosclerosis, with special emphasis on recent publications in the past 2 years...
  38. ncbi Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?
    Fumikazu Okajima
    Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi, Japan
    Biochim Biophys Acta 1582:132-7. 2002
    ..Furthermore, S1P content in LDL was markedly decreased during its oxidation. This paper will discuss whether S1P is an atherogenic mediator or an anti-atherogenic mediator...
  39. doi Smoking and smoking cessation -- the relationship between cardiovascular disease and lipoprotein metabolism: a review
    Sara Chelland Campbell
    Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306 1493, USA
    Atherosclerosis 201:225-35. 2008
    ..This review examines the current literature related to: (1) smoking, lipoproteins, and lipid-related enzymes; (2) the impact of nicotine, carbon monoxide and free radicals on physiologic ..
  40. pmc Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively
    K Lu
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA
    Am J Hum Genet 69:278-90. 2001
    ..Identification of sterolin-1 and sterolin-2 as critical players in the regulation of dietary-sterol absorption and excretion identifies a new pathway of sterol transport...
  41. pmc Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol
    Liqing Yu
    Department of Molecular Genetics and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9046, USA
    J Clin Invest 110:671-80. 2002
    ....
  42. doi Lipoprotein subfractions and cardiovascular disease risk
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Curr Opin Lipidol 21:305-11. 2010
    ..This review summarizes the properties of the major LDL and HDL particle subclasses, and recent evidence linking their measurement with risk of atherosclerosis and CVD...
  43. doi Molecular cross-talk in host-parasite relationships: the intriguing immunomodulatory role of Echinococcus antigen B in cystic echinococcosis
    Alessandra Siracusano
    Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Int J Parasitol 38:1371-6. 2008
    ..Besides focusing on findings that provide intriguing insights into the complex interplay between host and parasite, we suggest how this information could extend the current therapeutic options in inflammatory diseases...
  44. ncbi Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance
    W Timothy Garvey
    Division of Endocrinology and Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Diabetes 52:453-62. 2003
    ..It will be important to study whether NMR lipoprotein subclass parameters can be used to manage risk more effectively and prevent cardiovascular disease in patients with the IRS...
  45. ncbi Apolipoprotein E: far more than a lipid transport protein
    R W Mahley
    Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California 94141 9100, USA
    Annu Rev Genomics Hum Genet 1:507-37. 2000
    ..Functional differences in the apoE isoforms that affect (or did affect) survival before the reproductive years probably account, at least in part, for the allele frequencies of the present day...
  46. ncbi Role of lipids, lipoproteins and vitamins in women with breast cancer
    G Ray
    Department of Biosciences, Jamia Millia Islamia, 110025, New Delhi, India
    Clin Biochem 34:71-6. 2001
    ..Lipids, lipoproteins and antioxidative vitamins have been associated with the risk of breast cancer...
  47. ncbi The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity
    Stéphane Mandard
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
    J Biol Chem 281:934-44. 2006
    ..The composite data suggest that via physical association with plasma lipoproteins, FIAF acts as a powerful signal from fat and other tissues to prevent fat storage and stimulate fat ..
  48. ncbi The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL))
    M Dobiasova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Clin Biochem 34:583-8. 2001
    ..To evaluate if logarithm of the ratio of plasma concentration of triglycerides to HDL-cholesterol (Log[TG/HDL-C]) correlates with cholesterol esterification rates in apoB-lipoprotein-depleted plasma (FER(HDL)) and lipoprotein particle size...
  49. ncbi Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells
    Akio Kawakami
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 113:691-700. 2006
    b>Lipoproteins containing apolipoprotein (apo) CIII predict coronary heart disease and associate with components of the metabolic syndrome. ApoCIII inhibits lipoprotein catabolism in plasma...
  50. ncbi Trends in serum lipids and lipoproteins of adults, 1960-2002
    Margaret D Carroll
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    JAMA 294:1773-81. 2005
    ....
  51. ncbi Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus
    Masahito Hashimoto
    Department of Nanostructure and Advanced Materials, Kagoshima University, Kagoshima, Japan
    J Immunol 177:3162-9. 2006
    ..However, we previously demonstrated that LTA fraction prepared from bacterial cells contains lipoproteins, which activate cells via TLR2...
  52. ncbi Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em
    Matthew I Hutchings
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Trends Microbiol 17:13-21. 2009
    Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins...
  53. pmc Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol
    Jelske N van der Veen
    Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands
    J Biol Chem 284:19211-9. 2009
    ..This pathway is sensitive to pharmacological activation of the LXR system. These data support the concept that the intestine substantially contributes to reverse cholesterol transport...
  54. ncbi Identification of Francisella tularensis lipoproteins that stimulate the toll-like receptor (TLR) 2/TLR1 heterodimer
    Shalini Thakran
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 283:3751-60. 2008
    ..Here we report the identification of two Francisella lipoproteins, TUL4 and FTT1103, which activate TLR2...
  55. doi Why is non-high-density lipoprotein cholesterol a better marker of the risk of vascular disease than low-density lipoprotein cholesterol?
    Allan Sniderman
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Room H7 22, Royal Vic Hosp, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
    J Clin Lipidol 4:152-5. 2010
    ..Rather, non-HDL-C appears to be an indirect way of estimating apoB. We argue that we should integrate the information from non-HDL-C and apoB for better risk assessment and a better target of therapy...
  56. doi Dissecting the complete lipoprotein biogenesis pathway in Streptomyces scabies
    David A Widdick
    School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
    Mol Microbiol 80:1395-412. 2011
    Following translocation, bacterial lipoproteins are lipidated by lipoprotein diacylglycerol transferase (Lgt) and cleaved of their signal peptides by lipoprotein signal peptidase (Lsp)...
  57. doi Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation
    John D Brunzell
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, and the Northwest Lipid Laboratory, University of Washington, Seattle, Washington, USA
    Diabetes Care 31:811-22. 2008
  58. doi The cholesterol content of Western diets plays a major role in the paradoxical increase in high-density lipoprotein cholesterol and upregulates the macrophage reverse cholesterol transport pathway
    Joan Carles Escola-Gil
    Institut d Investigacions Biomèdiques Sant Pau, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 31:2493-9. 2011
    ..The present study aimed to determine the effects of this Western-type diet on high-density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT) from macrophages to feces...
  59. pmc Exercise, lipids, and lipoproteins in older adults: a meta-analysis
    George A Kelley
    Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506, USA
    Prev Cardiol 8:206-14. 2005
    The authors used the meta-analytic approach to examine the effects of aerobic exercise on lipids and lipoproteins in adults 50 years of age and older...
  60. ncbi Lipid and lipoprotein profile in physiological pregnancy
    Giuseppe Lippi
    Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita di Verona, Italy
    Clin Lab 53:173-7. 2007
    ..associated with a broad series of metabolic adaptations which may also influence the metabolism of lipids and lipoproteins. Although the modification of serum lipids and lipoproteins has been exhaustively investigated during and after ..
  61. doi Lipid disorders in type 1 diabetes
    B Verges
    Service d endocrinologie, de diabétologie et des maladies métaboliques, Hopital du Bocage, Dijon, France
    Diabetes Metab 35:353-60. 2009
    Patients with type 1 diabetes (T1D) also present with lipid disorders. Quantitative abnormalities of lipoproteins are observed in T1D patients with poor glycaemic control (increased plasma triglycerides and low-density lipoprotein [LDL] ..
  62. pmc ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis
    Lily Jakulj
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Lipid Res 51:3016-23. 2010
    ..Hence, associations between frequently studied missense ABCG5/G8 polymorphisms and markers of cholesterol homeostasis are modest at best...
  63. ncbi Alkylresorcinols from whole-grain wheat and rye are transported in human plasma lipoproteins
    Anna Maria Linko-Parvinen
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, Division of Clinical Chemistry, University of Helsinki, FIN 00014 Helsinki, Finland
    J Nutr 137:1137-42. 2007
    ..Plasma alkylresorcinols are transported in lipoproteins with VLDL and HDL being the main carriers...
  64. pmc Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption
    M H Lee
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina, USA
    Nat Genet 27:79-83. 2001
    ..H.L. et al., manuscript submitted). We now report that a new member of the ABC transporter family, ABCG5, is mutant in nine unrelated sitosterolemia patients...
  65. doi Ethnic differences in serum lipoproteins and their determinants in South African women
    Julia H Goedecke
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, 7700 South Africa
    Metabolism 59:1341-50. 2010
    ..The major determinants of serum lipids in black women were socioeconomic status and lifestyle factors, whereas in white women, S(I) and body composition most closely correlated with serum lipids...
  66. pmc Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy
    Lei Zhang
    Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Lipid Res 52:175-84. 2011
    ..Lipoprotein structure-function relationships provide important clues that help identify the role of lipoproteins in cardiovascular disease...
  67. pmc NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection
    Berenice Barajas
    Department of Medicine, University of California, Center for Health Sciences, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 31:58-66. 2011
    ..To test the hypothesis that NF-E2-related factor 2 (Nrf2) expression plays an antiatherogenic role by its vascular antioxidant and anti-inflammatory properties...
  68. doi Crystal structure of Escherichia coli BamB, a lipoprotein component of the β-barrel assembly machinery complex
    Kelly H Kim
    Department of Molecular Biology and Biochemistry, Simon Fraser University, South Science Building, 8888 University Drive, Burnaby, British Columbia, Canada
    J Mol Biol 406:667-78. 2011
    ..The BAM complex in Escherichia coli consists of five proteins: one β-barrel membrane protein, BamA, and four lipoproteins, BamB, BamC, BamD, and BamE...
  69. pmc Crossveinless d is a vitellogenin-like lipoprotein that binds BMPs and HSPGs, and is required for normal BMP signaling in the Drosophila wing
    Jun Chen
    Department of Zoology, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 139:2170-6. 2012
    ....
  70. ncbi SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA
    J Lipid Res 49:107-14. 2008
    ..Previous findings of increased atherosclerosis in mice transplanted with SR-BI(-/-) bone marrow probably cannot be explained by a defect in macrophage cholesterol efflux...
  71. pmc Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse
    Shu Wang
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Atherosclerosis 204:147-55. 2009
    ..These data suggest that lower omega-6:EPA+DHA ratio diets lowered some measures of inflammation and Mphi cholesterol accumulation, which was associated with less aortic lesion formation in LDLr-/- mice...
  72. pmc The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight
    Geesje M Dallinga-Thie
    Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 211:1-8. 2010
    ..In this review, we will provide an overview of novel data on both peripheral TG hydrolysis and hepatic remnant clearance that will improve our knowledge of plasma triglyceride metabolism...
  73. pmc Kinetic control of TolC recruitment by multidrug efflux complexes
    Elena B Tikhonova
    Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Room 208, Norman, OK 73019, USA
    Proc Natl Acad Sci U S A 106:16416-21. 2009
    ..We propose that recruitment of TolC by various MFPs is determined not only by kinetics of MFP-TolC interactions but also by oligomerization kinetics of MFPs and pH...
  74. ncbi Patched regulates Smoothened trafficking using lipoprotein-derived lipids
    Helena Khaliullina
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 136:4111-21. 2009
    ..Here, we show that Drosophila Ptc recruits internalized lipoproteins to Ptc-positive endosomes and that its sterol-sensing domain regulates trafficking of both lipids and Smo from ..
  75. doi Effects of high-density lipoproteins on pancreatic beta-cell insulin secretion
    Michelle A Fryirs
    The Heart Research Institute, Sydney, New South Wales, Australia
    Arterioscler Thromb Vasc Biol 30:1642-8. 2010
    ..Given the current interest in therapeutic interventions that raise HDLs levels, this study investigates the effects of HDLs on insulin secretion from beta-cells...
  76. pmc Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 30:1430-8. 2010
    ....
  77. pmc Definition of the bacterial N-glycosylation site consensus sequence
    Michael Kowarik
    Institute of Microbiology, Department of Biology, Swiss Federal Institute of Technology Zurich, ETH Honggerberg, Switzerland
    EMBO J 25:1957-66. 2006
    ..Thus, bacterial N-glycosylation site selection is more specific than the eukaryotic equivalent with respect to the polypeptide acceptor sequence...
  78. pmc Assembly and channel opening in a bacterial drug efflux machine
    Vassiliy N Bavro
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Mol Cell 30:114-21. 2008
    ..We suggest that the assembly of multidrug efflux pumps is accompanied by induced fit of TolC driven mainly by accommodation of the periplasmic component...
  79. ncbi Lipoprotein synthesis in mycobacteria
    Mandana Rezwan
    Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 32, CH 8006 Zurich, Switzerland
    Microbiology 153:652-8. 2007
    b>Lipoproteins are a functionally diverse class of secreted bacterial proteins characterized by an N-terminal lipid moiety. The lipid moiety serves to anchor these proteins to the cell surface...
  80. pmc The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferi
    Xiaofeng F Yang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    Proc Natl Acad Sci U S A 100:11001-6. 2003
    ..a two-component sensory transduction system, is a pivotal regulator governing the expression of major membrane lipoproteins such as OspC, DbpA, and Mlp8, as well as many other mammalian infection-associated immunogens of Bb...
  81. ncbi Novel aspects of postprandial lipemia in relation to atherosclerosis
    A Alipour
    Department of Internal Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands
    Atheroscler Suppl 9:39-44. 2008
    ..The atherogenic mechanisms of postprandial lipids and lipoproteins can be divided into direct lipoprotein-mediated and indirect effects; the latter, in part, by inducing an ..
  82. ncbi A detailed molecular belt model for apolipoprotein A-I in discoidal high density lipoprotein
    J P Segrest
    Department of Medicine, University of Alabama Birmingham Medical Center, Birmingham, Alabama 35294, USA
    J Biol Chem 274:31755-8. 1999
    ..The resulting model is an antiparallel arrangement with an alignment matching that of the (nonplanar) crystal structure of lipid-free apoA-I...
  83. ncbi Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials
    J C LaRosa
    Office of the President, State University of New York Health Science Center at Brooklyn, 11203, USA
    JAMA 282:2340-6. 1999
    ..Lowering low-density lipoprotein cholesterol (LDL-C) is known to reduce risk of recurrent coronary heart disease in middle-aged men. However, this effect has been uncertain in elderly people and women...
  84. pmc Identification of immunodominant B- and T-cell combined epitopes in outer membrane lipoproteins LipL32 and LipL21 of Leptospira interrogans
    Xu Ai Lin
    Department of Medical Microbiology and Parasitology, School of Medicine, Zhejiang University, Hangzhou 310058, China
    Clin Vaccine Immunol 17:778-83. 2010
    ..LipL32 and LipL21 are the conserved outer membrane lipoproteins of L. interrogans and are considered vaccine candidates...
  85. pmc Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice
    Kristin I Stanford
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0687, USA
    J Clin Invest 119:3236-45. 2009
    ..In mice, accumulation of triglyceride-rich lipoproteins can occur if sulfation of heparan sulfate in hepatocytes is diminished, as this alters hepatic lipoprotein ..
  86. ncbi Remnant lipoproteins and atherogenesis
    Akio Kawakami
    Department of Geriatrics and Vascular Medicine, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima D809, Bunkyo ku, Tokyo, Japan
    J Atheroscler Thromb 12:73-6. 2005
    ..triglyceride (TG) levels are closely related to atherosclerosis, independently of serum levels of high-density lipoproteins (HDL) and low-density lipoproteins (LDL)...
  87. pmc Funnel-like hexameric assembly of the periplasmic adapter protein in the tripartite multidrug efflux pump in gram-negative bacteria
    Yongbin Xu
    Department of Manufacturing Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 609 735, Republic of Korea
    J Biol Chem 286:17910-20. 2011
    ....
  88. ncbi AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex
    Elena B Tikhonova
    Department of Chemistry and Biochemistry, University of Oklahoma, Norman, 73019, USA
    J Biol Chem 279:32116-24. 2004
    ..We show that antibiotics, the substrates of AcrAB-TolC, stabilize interactions within the complex. However, the formation of the AcrAB-TolC complex does not require an input of energy...
  89. ncbi TAT-pathway-dependent lipoproteins as a niche-based adaptation in prokaryotes
    Hamsanathan Shruthi
    Centre for Biotechnology, Anna University, Chennai 600 025, Tamil Nadu, India
    J Mol Evol 70:359-70. 2010
    Bacterial lipoproteins, characterized by the N-terminal N-acyl S-diacylglyceryl Cysteine, are key membrane proteins in bacterial homeostasis...
  90. ncbi Recent insights into factors affecting remnant lipoprotein uptake
    Kevin Jon Williams
    Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Curr Opin Lipidol 21:218-28. 2010
    Remnant lipoproteins that persist in the bloodstream after each meal have become increasingly important contributors to atherosclerotic vascular disease, owing to the spread of overnutrition, underexertion, obesity, insulin resistance, ..
  91. pmc Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2
    Michael G Drage
    Department of Pathology, Case Western Reserve University University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Nat Struct Mol Biol 17:1088-95. 2010
    ..In conclusion, we demonstrate a glycolipid binding function of LprG that enhances recognition of triacylated MTB glycolipids by TLR2 and may affect glycolipid assembly or transport for bacterial cell wall biogenesis...
  92. pmc Lipoprotein lipase bound to apolipoprotein B lipoproteins accelerates clearance of postprandial lipoproteins in humans
    Chunyu Zheng
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 26:891-6. 2006
    Experiments in cells and animal models show that lipoprotein lipase (LpL) bound to apolipoprotein (apo)B lipoproteins enhances their uptake by receptor mediated pathways. It is unknown whether this pathway is important in humans.
  93. pmc Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages
    Preetha Shridas
    Graduate Center for Nutritional Sciences, Saha Cardiovascular Research Center, University of Kentucky Medical Center, Lexington 40536 0200, USA
    Arterioscler Thromb Vasc Biol 30:2014-21. 2010
    ....
  94. ncbi Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus
    Eric A Schwartz
    Department of Endocrinology, Phoenix VA Health Care System, 650 E Indian School Road 111E, Phoenix, AZ 85012 1892, USA
    Atherosclerosis 212:217-22. 2010
    ..Therefore, the effect of a single injection of exenatide on postprandial lipids, remnant lipoproteins, and apolipoproteins was studied.
  95. pmc Conformational flexibility in the multidrug efflux system protein AcrA
    Jonathan Mikolosko
    Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92037, USA
    Structure 14:577-87. 2006
    ..Notably, unsuspected conformational flexibility in the alpha-helical hairpin domain of AcrA is observed, which has potential mechanistic significance in coupling between AcrA conformations and TolC channel opening...
  96. pmc Sequential mechanism of assembly of multidrug efflux pump AcrAB-TolC
    Elena B Tikhonova
    Department of Chemistry and Biochemistry, Stephenson Life Science Research Center, University of Oklahoma, Norman, OK 73019, USA
    Chem Biol 18:454-63. 2011
    ..The conformation of the membrane proximal domain of AcrA is critical for the formation of AcrAB-TolC and could be targeted for the development of new inhibitors...
  97. ncbi An analytical method for size and shape characterization of blood lipoproteins
    Diana Cristina Rambaldi
    Department of Chemistry G Ciamician, Bologna, Italy
    Clin Chem 53:2026-9. 2007
  98. pmc Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Gastroenterology 134:424-31. 2008
    ..The purpose of this study was to evaluate TG metabolism in adipose tissue and liver in NAFLD...
  99. pmc Staphylococcus aureus lipoproteins trigger human corneal epithelial innate response through toll-like receptor-2
    Qiong Li
    Kresge Eye Institute Department of Ophthalmology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Microb Pathog 44:426-34. 2008
    Bacterial lipoproteins (LP) are a family of cell wall components found in a wide variety of bacteria...
  100. pmc Atherogenesis and the humoral immune response to modified lipoproteins
    Gabriel Virella
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, United States
    Atherosclerosis 200:239-46. 2008
    ..There is no conclusive evidence supporting a protective role for IgM antibodies in humans, possibly because autoantibodies to modified lipoproteins are predominantly of the IgG isotype.
  101. ncbi New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism
    Laura Calpe-Berdiel
    Servei de Bioquimica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Atherosclerosis 203:18-31. 2009
    ..This article reviews the progress to date in studying these effects of phytosterols/phytostanols and the molecular mechanisms involved...

Research Grants140 found, 100 shown here

  1. Quercetin and Innate Immune Responses in COPD
    UMADEVI SIVANAPPA SAJJAN; Fiscal Year: 2010
    ..Underlying cellular and biochemical mechanisms will also be examined. This proposal may lead to a new nutraceutical treatment for COPD. ..
  2. MECHANISMS IN THE REGULATION OF SP-A GENE EXPRESSION
    Carole R Mendelson; Fiscal Year: 2013
    ....
  3. MECHANISMS IN THE REGULATION OF SP-A GENE EXPRESSION
    Carole R Mendelson; Fiscal Year: 2011
    ....
  4. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2009
    ..In the future, individual patients with variation in these genes may benefit from targeted behavioral and/or pharmacological interventions designed to improve their health. ..
  5. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2010
    ..In the future, individual patients with variation in these genes may benefit from targeted behavioral and/or pharmacological interventions designed to improve their health. ..
  6. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..We will assay markers of: (1) lipids and lipoproteins (apoA-I, apoA-II, apoB, apoC-III, apoE, lipoprotein(a), lipoprotein subclasses, oxidized phospholipids, ..
  7. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Daniel Rader; Fiscal Year: 2009
    ..We will assay markers of: (1) lipids and lipoproteins (apoA-I, apoA-II, apoB, apoC-III, apoE, lipoprotein(a), lipoprotein subclasses, oxidized phospholipids, ..
  8. Role of Macronutrient Diet Composition on Maternal and Infant Metabolic Outcomes
    TERI HERNANDEZ; Fiscal Year: 2010
    ..by measuring serial plasma TG and FFA over a 5-hour, post-breakfast meal period within subjects;and 3) maternal lipoproteins, inflammatory profiles, and in-vitro adipose tissue lipolysis after 6-8 weeks of diet therapy between subjects...
  9. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..We are proposing studies that will provide a more complete understanding of relationships between alcohol consumption, vitamin A metabolism and actions, and alcoholic organ damage. ..
  10. Retinoid Metabolism and Alcohol Induced Disease
    WILLIAM BLANER; Fiscal Year: 2009
    ..We are proposing studies that will provide a more complete understanding of relationships between alcohol consumption, vitamin A metabolism and actions, and alcoholic organ damage. ..
  11. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ..apo) B synthesis through increased apob gene transcription which favors hepatic TG export in very low density lipoproteins (VLDL) and reduces liver TG content by 45%...
  12. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ..apo) B synthesis through increased apob gene transcription which favors hepatic TG export in very low density lipoproteins (VLDL) and reduces liver TG content by 45%...
  13. Prolonged Inhibition of Pathologic Neovascularization by Catalytic Antioxidants
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2013
    ....
  14. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2010
    ..Aim #2 will investigate the oxidative modification of lipoproteins and lipids by VPO. The ability of purified VPO to oxidize LDL lipoprotein and lipid will be emphasized...
  15. Regulation of Hepatic Lipid and Glucose Metabolism by Phosphatidylcholine Transfe
    David E Cohen; Fiscal Year: 2010
    ..It is anticipated that these experiments may establish phosphatidylcholine transfer protein/StarD2 as a molecular target for the management of insulin resistance. ..
  16. Regulation of Hepatic Lipid and Glucose Metabolism by Phosphatidylcholine Transfe
    David Cohen; Fiscal Year: 2009
    ..It is anticipated that these experiments may establish phosphatidylcholine transfer protein/StarD2 as a molecular target for the management of insulin resistance. ..
  17. Regulation of Hepatic Lipid and Glucose Metabolism by Phosphatidylcholine Transfe
    David Cohen; Fiscal Year: 2009
    ..It is anticipated that these experiments may establish phosphatidylcholine transfer protein/StarD2 as a molecular target for the management of insulin resistance. ..
  18. Thyroid Hormone Action
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ....
  19. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..The greatest potential for arresting this epidemic is likely to come through a clearer understanding of its molecular pathogenesis to develop rational and mechanism based therapy. ..
  20. Metabolic impact of fructose restriction in obese children
    JEAN MARC contact SCHWARZ; Fiscal Year: 2010
    ..abstract_text> ..
  21. Regulation of Hepatic SphK2 by Bile Acids: Effects on Lipid Metabolism
    HUIPING ROSE ZHOU; Fiscal Year: 2013
    ..genes encoding enzymes/proteins involved in the metabolism/synthesis of bile acids, glucose, fatty acids, and lipoproteins as well as energy metabolism by activating specific nuclear receptors, a G protein coupled receptor (GPCR, TGR5)..
  22. Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodege
    Thomas O Obisesan; Fiscal Year: 2010
    ....
  23. Fatty Acid Regulation of Liver Lipoprotein Production
    Henry N Ginsberg; Fiscal Year: 2010
    The combination of increased secretion of triglyceride (TG)-rich apolipoprotein B (apoB) lipoproteins (Lps) and hepatic steatosis, are characteristic concomitants of insulin resistance, the metabolic syndrome, and type 2 diabetes ..
  24. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2013
    ..by adipose tissue (AT) and liver-and with increased hepatic production of triglyceride-rich lipoproteins (TGRLs) and increased levels of fatty acids (FAs, saturated FAs in particular)...
  25. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2010
    ..by adipose tissue (AT) and liver-and with increased hepatic production of triglyceride-rich lipoproteins (TGRLs) and increased levels of fatty acids (FAs, saturated FAs in particular)...
  26. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2010
    Lymph is rich in lipids, including lipoproteins, and the return of cholesterol from tissues to the vasculature and ultimately the liver depends not only on the loading of cholesterol onto high-density lipoprotein (HDL) particles within ..
  27. The APOE TR Mouse: A Model for Elucidating Pathogenic Mechanisms of AMD
    Catherine Bowes Rickman; Fiscal Year: 2010
    ..Validation of A[unreadable] as a novel therapeutic target in AMD could lead to a fundamental paradigm shift in the understanding and treatment of AMD. ..
  28. The Impact of Obstructive Sleep Apnea on Non-Alcoholic Fatty Liver Disease
    KATHLEEN ELIZABETH COREY; Fiscal Year: 2013
    ..in 8 first author publications including the identification of a two lipid biomarkers, oxidized low density lipoproteins (OxLDL) and non-high density lipoprotein cholesterol for NAFLD...
  29. Chemical Biology Studies of 3-Iodothyronamine and Related Thyroid Hormone Metabol
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..4) Determine the mechanism of intracellular uptake of T1AM and search for T1AM target proteins. ..
  30. MECHANISMS OF MILK LIPID SECRETION
    JAMES LEWIS MCMANAMAN; Fiscal Year: 2010
    ....
  31. MECHANISMS OF MILK LIPID SECRETION
    JAMES LEWIS MCMANAMAN; Fiscal Year: 2013
    ....
  32. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2010
    ..This animal model will provide academic and industrial research communities with an opportunity to better understand cardiovascular disease and its pathogenesis, and to develop and test new therapeutics and preventative strategies. ..
  33. Mechanisms of ethanol-induced neurodevelopmental effects
    Marina Guizzetti; Fiscal Year: 2010
    ..brain, cholesterol is mostly produced endogenously, and its homeostasis is regulated by endogenously produced lipoproteins and cholesterol transporters...
  34. The Postischemia Inflammatory Syndrome in the Aged Kidney
    KATHERINE JULIA KELLY; Fiscal Year: 2013
    ..Nearly one-half of patient beginning dialysis for CKD were e65 yo. We propose to study inflammatory and vascular injury and cell death and the effects of potential therapies in a model of CKD. ..
  35. The Postischemia Inflammatory Syndrome in the Aged Kidney
    KATHERINE JULIA KELLY; Fiscal Year: 2010
    ..Nearly one-half of patient beginning dialysis for CKD were e65 yo. We propose to study inflammatory and vascular injury and cell death and the effects of potential therapies in a model of CKD. ..
  36. Mechanisms of Obesity in Mice with Neuron-Specific Lipoprotein Lipase Deficiency
    Robert H Eckel; Fiscal Year: 2013
    ..is the rate limiting enzyme for the uptake of fatty acids from the hydrolysis of circulating triglyceride-rich lipoproteins for lipid storage and/or oxidation in peripheral tissues...
  37. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013
    ..myeloperoxidase (MPO);3) cell free hemoglobin (Hb);and, 4) oxidized lipids prevents oxidation of HDL and other lipoproteins in the SCD mice with asthma...
  38. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    KIRKWOOD A contact PRITCHARD; Fiscal Year: 2010
    ..myeloperoxidase (MPO);3) cell free hemoglobin (Hb);and, 4) oxidized lipids prevents oxidation of HDL and other lipoproteins in the SCD mice with asthma...
  39. Regulation of Triglyceride Metabolism by the transcription factor CREB-H
    Ann Hwee Lee; Fiscal Year: 2013
    ....
  40. Does Diabetic Hyperglycemia Regulate Atherosclerosis Progression and Regression?
    ROBERT RAFFAI; Fiscal Year: 2009
    ..Lastly, we will test the hypothesis that high density lipoproteins isolated from hyperglycemic Apoeh/hLdlr-/-Mx1-Cre mice will display a reduced ability to promote lipid ..
  41. Role of Lipid Phosphatases in Cholesterol and Triglyceride Synthesis
    Andrew J Morris; Fiscal Year: 2010
    ..in circulating levels of cholesterol and triglycerides and alterations in the composition of circulating lipoproteins are major risk factors for cardiovascular and cerebrovascular disease. Obesity is a disorder of energy balance...
  42. Metabolic impact of fructose restriction in obese children
    Jean Marc Schwarz; Fiscal Year: 2013
    ..abstract_text> ..
  43. Role of Lipid Phosphatases in Cholesterol and Triglyceride Synthesis
    Andrew J Morris; Fiscal Year: 2010
    ..in circulating levels of cholesterol and triglycerides and alterations in the composition of circulating lipoproteins are major risk factors for cardiovascular and cerebrovascular disease. Obesity is a disorder of energy balance...
  44. Adiponectin and fetal programming
    Jianhua Shao; Fiscal Year: 2013
    ..These studies will reveal new pathways of fetal programming that will lead to new therapeutic approaches to stop the vicious cycle of maternal-offspring obesity. ..
  45. The wnt signaling pathway in choroidal neovascularization
    Jian Xing Ma; Fiscal Year: 2010
    ..This project aims to explore a novel pathogenic mechanism for choroidal neovascularization and to establish a new animal model of choroidal neovascularization. ..
  46. Metabolic Actions of Omega-3 Fatty Acids on Inflammation
    Michael Miller; Fiscal Year: 2013
    ..ALA supplementation on 1) Metabolic (e.g., lipoproteins, inflammatory cytokines, acute phase reactants, glucose tolerance/insulin resistance) and adipose tissue ..
  47. High Density Lipoprotein (HDL) in Follicular Fluid and Fertility Outcomes
    VICTOR YUTAKA FUJIMOTO; Fiscal Year: 2010
    ..studying HDL-mediated cholesterol metabolism and transport mechanisms in a physiologic system devoid of other lipoproteins. Understanding how modifications of HDL within FF render it dysfunctional would add greater depth of ..
  48. Regulation of factor VIII Levels and Activity by Members of LDL Receptor Family
    DUDLEY K contact STRICKLAND; Fiscal Year: 2010
    ..endocytic receptor that plays an important role in the catabolism of several ligands including apoE-enriched lipoproteins, plasminogen activators, and serpin-enzyme complexes...
  49. Regulation of factor VIII Levels and Activity by Members of LDL Receptor Family
    Dudley K Strickland; Fiscal Year: 2013
    ..endocytic receptor that plays an important role in the catabolism of several ligands including apoE-enriched lipoproteins, plasminogen activators, and serpin-enzyme complexes...
  50. Adipose Tissue Macrophage Phenotype and Function
    Anthony W Ferrante; Fiscal Year: 2013
    ....
  51. Plasma Lipid Markers and Cancer Risk
    Lu Wang; Fiscal Year: 2013
    ....
  52. Hepatic Lipase and HCV Infection
    Tianyi Wang; Fiscal Year: 2010
    ..Because it is known that HSPG mediates the initial HCV attachment and circulating HCV associates with lipoproteins, we hypothesize that elevated levels of HL and LPL may regulate the HCV infection and production in either cell-..
  53. Regulation of Signaling Receptor Activity by LRP-1
    Steven L Gonias; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Low density lipoprotein receptor-related protein has emerged as an important regulator of inflammation and atherosclerosis. This proposal seeks to elucidate the responsible mechanisms. ..
  54. Lipoprotein Structure and Function by Individual Particle Electron Tomography
    Gang Ren; Fiscal Year: 2013
    ..Major risk factors for CVD are the plasma lipoprotein levels. Lipoproteins are classified according to their densities as high , low-, intermediate- and very low-density lipoproteins (..
  55. Regulation of Signaling Receptor Activity by LRP-1
    Steven L Gonias; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Low density lipoprotein receptor-related protein has emerged as an important regulator of inflammation and atherosclerosis. This proposal seeks to elucidate the responsible mechanisms. ..
  56. Sphingosine 1-phosphate and cardioprotection
    JOEL SAMUEL KARLINER; Fiscal Year: 2010
    ..Secretion of S1P leads to extensive binding by albumin and plasma lipoproteins and circulation at nanomolar to micromolar concentrations...
  57. Over-Expression of microRNA-126 in Macrophages for Treatment of Atherosclerosis
    Suzette Laing; Fiscal Year: 2013
    ..In atherosclerosis, the earliest lesions contain macrophages that have phagocytized and accumulated modified lipoproteins. The continued monocyte recruitment and cholesterol accumulation in the vessel wall facilitates chronic disease ..
  58. Group B. Streptococci and Toll-like Receptors
    Douglas T Golenbock; Fiscal Year: 2010
    ..First, we have identified lipoproteins as endotoxins that constitute functional equivalents to the well defined lipopolysaccharide in Gram-negative ..
  59. Role of NPC1L1 in regulating energy metabolism, nutrient utilization & weight gai
    Philip N Howles; Fiscal Year: 2010
    ..Preliminary studies into other physiological effects of ezetimibe have revealed that postprandial intestinal lipoproteins from ezetimibe-treated mice are different in size and composition than those from control mice...
  60. Optimal Selective Thyroid Hormone Analogs for Metabolic Syndrome
    John D Baxter; Fiscal Year: 2010
    ..We will find drugs that will safely treat high cholesterol and obesity and work through one class of these proteins, thyroid hormone receptors. ..
  61. Apo E mimetics reduce cholesterol and improve HDL function
    G M Anantharamaiah; Fiscal Year: 2010
    ..This proposal deals with ways of incorporating properties of lowering plasma apolipoprotein B- containing lipoproteins with properties of improving HDL function...
  62. Apo E mimetics reduce cholesterol and improve HDL function
    G Anantharamaiah; Fiscal Year: 2009
    ..This proposal deals with ways of incorporating properties of lowering plasma apolipoprotein B- containing lipoproteins with properties of improving HDL function...
  63. BONE MARROW TRANSPLANTION AND ATHEROSCLEROSIS
    MacRae Linton; Fiscal Year: 1999
    ..The majority of apoE in the plasma lipoproteins is of hepatic origin, and the relative contribution of extrahepatic apoE to the metabolism of the plasma ..
  64. Surface Lipoproteins and Serum Resistance in Borrelia burgdorferi
    Darrin R Akins; Fiscal Year: 2010
    ..Recently, several B. burgdorferi outer surface lipoproteins (Osp) were identified by us and others that can bind factor H in vitro...
  65. Cholesterol and Lymphatic Transport of Molecules and Cells
    Gwendalyn Randolph; Fiscal Year: 2009
    Lymph is rich in lipids, including lipoproteins, and the return of cholesterol from tissues to the vasculature and ultimately the liver depends not only on the loading of cholesterol onto high-density lipoprotein (HDL) particles within ..
  66. Mechanisms of ethanol-induced neurodevelopmental effects
    Marina Guizzetti; Fiscal Year: 2009
    ..brain, cholesterol is mostly produced endogenously, and its homeostasis is regulated by endogenously produced lipoproteins and cholesterol transporters...
  67. Role of Genes in Exceptional Longevity in Humans
    Nir Barzilai; Fiscal Year: 2007
    ..In addition, the Administrative Core is charged with maintaining relationships and contact with enrolled subjects, which is critical to the success of the longitudinal study design. ..
  68. Role of Genes in Exceptional Longevity in Humans
    Nir Barzilai; Fiscal Year: 2009
    ..In addition, the Administrative Core is charged with maintaining relationships and contact with enrolled subjects, which is critical to the success of the longitudinal study design. ..
  69. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2009
    ..Aim #2 will investigate the oxidative modification of lipoproteins and lipids by VPO. The ability of purified VPO to oxidize LDL lipoprotein and lipid will be emphasized...
  70. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2003
    DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
  71. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2002
    DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
  72. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2002
    DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
  73. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2004
    DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
  74. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2001
    DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
  75. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2000
    DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
  76. Antigenic variation by multiple promoter inversions in Mycoplasma penetrans
    Michael Calcutt; Fiscal Year: 2009
    ..penetrans-derived lipoproteins stimulate HIV-1 replication, raises the possibility that this Mycoplasma may be a contributory co-pathogen in ..
  77. Endoplasmic reticulum stress and foam cell formation
    Zhongmao Guo; Fiscal Year: 2009
    ..Similarly, ApoE-deficient (ApoE-/-) mice elevate plasma ApoB48-carrying lipoproteins and develop atherosclerosis in a manner that resembles the human disease...
  78. Pathogenesis of Lyme Borreliosis in the Rhesus Monkey
    MARIO PHILIPP; Fiscal Year: 2004
    ..The secondary hypothesis is that spirochetal lipoproteins can induce, in part or in toto, the inflammatory effects of B. burgdorferi...
  79. Pathogenesis of Lyme Borreliosis in the Rhesus Monkey
    MARIO PHILIPP; Fiscal Year: 2005
    ..The secondary hypothesis is that spirochetal lipoproteins can induce, in part or in toto, the inflammatory effects of B. burgdorferi...
  80. Endoplasmic reticulum stress and foam cell formation
    Zhongmao Guo; Fiscal Year: 2010
    ..Similarly, ApoE-deficient (ApoE-/-) mice elevate plasma ApoB48-carrying lipoproteins and develop atherosclerosis in a manner that resembles the human disease...
  81. ASSEMBLY OF NASCENT PLASMA LIPOPROTEINS BY HEPATOCYTES
    Robert Hamilton; Fiscal Year: 1991
    ..abstract): The long-term goals of this research are to determine the mechanisms by which hepatocytes secrete lipoproteins and apolipoproteins...
  82. Structural Thermodynamics of Human Apolipoprotein C-1
    Olga Gursky; Fiscal Year: 2006
    ..determine in molecular detail the energetic-structure-function relationship in exchangeable apolipoproteins and lipoproteins, thereby providing an insight into molecular mechanisms of lipoprotein action in the pathogenesis of ..
  83. Pathogenesis of Lyme Borreliosis in the Rhesus Monkey
    MARIO PHILIPP; Fiscal Year: 2006
    ..The secondary hypothesis is that spirochetal lipoproteins can induce, in part or in toto, the inflammatory effects of B. burgdorferi...
  84. Structural Thermodynamics of Human Apolipoprotein C-1
    Olga Gursky; Fiscal Year: 2003
    ..determine in molecular detail the energetic-structure-function relationship in exchangeable apolipoproteins and lipoproteins, thereby providing an insight into molecular mechanisms of lipoprotein action in the pathogenesis of ..
  85. Structural Thermodynamics of Human Apolipoprotein C-1
    Olga Gursky; Fiscal Year: 2007
    ..determine in molecular detail the energetic-structure-function relationship in exchangeable apolipoproteins and lipoproteins, thereby providing an insight into molecular mechanisms of lipoprotein action in the pathogenesis of ..
  86. Pathogenesis of Lyme Borreliosis in the Rhesus Monkey
    MARIO PHILIPP; Fiscal Year: 2007
    ..The secondary hypothesis is that spirochetal lipoproteins can induce, in part or in toto, the inflammatory effects of B. burgdorferi...
  87. PROTEASE INHIBITOR RELATED DYSLIPIDEMIA
    Christine Wanke; Fiscal Year: 2004
    ..in the constantly fed state and deuterated leucine, the secretion and catabolism of apoB-48 and apoB-100 within lipoproteins will be determined by GC/MS analysis and multicompartmental modeling in the presence or absence of protease ..
  88. PROTEASE INHIBITOR RELATED DYSLIPIDEMIA
    Christine Wanke; Fiscal Year: 2000
    ..in the constantly fed state and deuterated leucine, the secretion and catabolism of apoB-48 and apoB-100 within lipoproteins will be determined by GC/MS analysis and multicompartmental modeling in the presence or absence of protease ..
  89. PROTEASE INHIBITOR RELATED DYSLIPIDEMIA
    Christine Wanke; Fiscal Year: 2003
    ..in the constantly fed state and deuterated leucine, the secretion and catabolism of apoB-48 and apoB-100 within lipoproteins will be determined by GC/MS analysis and multicompartmental modeling in the presence or absence of protease ..
  90. PROTEASE INHIBITOR RELATED DYSLIPIDEMIA
    Christine Wanke; Fiscal Year: 2001
    ..in the constantly fed state and deuterated leucine, the secretion and catabolism of apoB-48 and apoB-100 within lipoproteins will be determined by GC/MS analysis and multicompartmental modeling in the presence or absence of protease ..
  91. PROTEASE INHIBITOR RELATED DYSLIPIDEMIA
    Christine Wanke; Fiscal Year: 2002
    ..in the constantly fed state and deuterated leucine, the secretion and catabolism of apoB-48 and apoB-100 within lipoproteins will be determined by GC/MS analysis and multicompartmental modeling in the presence or absence of protease ..
  92. APOE3 AND APOE4 EFFECTS ON CELLULAR PATHOBIOLOGY
    ROBERT PITAS; Fiscal Year: 1999
    ..Only apoE added to the cell with beta- migrating very low density lipoproteins (beta-VLDL) or lipid emulsions had an effect, and the effect was blocked by reductive methylation of apoE or by ..
  93. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2007
    ..will be determined by the 2-dimensional gel analysis, and indicate the capabilities of the systems to mimic lipoproteins. Kinetic studies of the particle delivery systems bi-directionally across Brain Blood Barrier (BBB) will be ..
  94. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2009
    ..will be determined by the 2-dimensional gel analysis, and indicate the capabilities of the systems to mimic lipoproteins. Kinetic studies of the particle delivery systems bi-directionally across Brain Blood Barrier (BBB) will be ..
  95. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2010
    ..will be determined by the 2-dimensional gel analysis, and indicate the capabilities of the systems to mimic lipoproteins. Kinetic studies of the particle delivery systems bi-directionally across Brain Blood Barrier (BBB) will be ..
  96. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2009
    ..will be determined by the 2-dimensional gel analysis, and indicate the capabilities of the systems to mimic lipoproteins. Kinetic studies of the particle delivery systems bi-directionally across Brain Blood Barrier (BBB) will be ..
  97. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2002
    ..Obesity increases CHD risk by adversely affecting glucose, lipoproteins, and blood pressure...
  98. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2000
    ..Obesity increases CHD risk by adversely affecting glucose, lipoproteins, and blood pressure...
  99. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 1999
    ..Obesity increases CHD risk by adversely affecting glucose, lipoproteins, and blood pressure...