Genomes and Genes
Summary: Any of the lipid-protein complexes in which lipids are transported in the blood. Lipoprotein particles consist of a spherical hydrophobic core of triglycerides or cholesteryl esters surrounded by an amphipathic monolayer of phospholipids, cholesterol, and apolipoproteins. (From Dorland, 27th ed)
Publications246 found, 100 shown here
- The protein moiety of Brucella abortus outer membrane protein 16 is a new bacterial pathogen-associated molecular pattern that activates dendritic cells in vivo, induces a Th1 immune response, and is a promising self-adjuvanting vaccine against systemic aKarina A Pasquevich
Laboratory of Immunogenetics, Clinical Hospital José de San Martín, School of Medicine, University of Buenos Aires, Buenos Aires
J Immunol 184:5200-12. 2010Knowing the inherent stimulatory properties of the lipid moiety of bacterial lipoproteins, we first hypothesized that Brucella abortus outer membrane protein (Omp)16 lipoprotein would be able to elicit a protective immune response without ..
- Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver diseaseKerry L Donnelly
Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St Paul, Minnesota, 55108, USA
J Clin Invest 115:1343-51. 2005..These quantitative metabolic data document that both elevated peripheral fatty acids and DNL contribute to the accumulation of hepatic and lipoprotein fat in NAFLD...
- Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sexM Cnop
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151 and University of Washington, 1660 S Columbian Way, Seattle, WA 98108, USA
Diabetologia 46:459-69. 2003..We investigated the relationships between adiponectin and leptin, body fat distribution, insulin sensitivity and lipoproteins.
- Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cellsA S Plump
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
Cell 71:343-53. 1992..This marked hypercholesterolemia is primarily due to elevated levels of very low and intermediate density lipoproteins. At 10 weeks of age, apoE-deficient mice have already developed atherosclerotic lesions in the aorta and ..
- Effects of the amount and intensity of exercise on plasma lipoproteinsWilliam E Kraus
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
N Engl J Med 347:1483-92. 2002..However, the amount of exercise training required for optimal benefit is unknown. In a prospective, randomized study, we investigated the effects of the amount and intensity of exercise on lipoproteins.
- Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for managementM John Chapman
European Atherosclerosis Society, INSERM UMR S939, Pitie Salpetriere University Hospital, Paris 75651, France
Eur Heart J 32:1345-61. 2011..This paper aims (i) to critically appraise evidence for elevated levels of triglyceride-rich lipoproteins (TRLs) and low levels of high-density lipoprotein cholesterol (HDL-C) as cardiovascular risk factors, and (ii) ..
- Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in miceLaurent Yvan-Charvet
Division of Molecular Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Invest 117:3900-8. 2007..These results suggest that the combined effects of ABCA1 and ABCG1 in mediating macrophage sterol efflux are central to the antiatherogenic properties of HDL...
- Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretionLiqing Yu
McDermott Center for Human Growth and Development and Departments of Molecular Genetics and Biochemistry, The Howard Hughes Medical Institute and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 99:16237-42. 2002....
- Prediction of lipoprotein signal peptides in Gram-negative bacteriaAgnieszka S Juncker
Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby 2800, Denmark
Protein Sci 12:1652-62. 2003..The hidden Markov model (HMM) was able to distinguish between lipoproteins (SPaseII-cleaved proteins), SPaseI-cleaved proteins, cytoplasmic proteins, and transmembrane proteins...
- Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and womenBørge G Nordestgaard
Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
JAMA 298:299-308. 2007Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis.
- Echinococcus granulosus antigen B impairs human dendritic cell differentiation and polarizes immature dendritic cell maturation towards a Th2 cell responseRachele Riganò
Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Infect Immun 75:1667-78. 2007..granulosus-stimulated DC maturation. These results suggest that E. granulosus escapes host immunosurveillance in two ways: by interfering with monocyte differentiation and by modulating DC maturation...
- Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coliTao Wu
Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
Cell 121:235-45. 2005..These genetic interactions suggest a role for YfgL, one of the lipoprotein components of the protein assembly complex, in a homeostatic control mechanism that coordinates the overall OM assembly process...
- ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferationLaurent Yvan-Charvet
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
Science 328:1689-93. 2010..The findings indicate that ABCA1, ABCG1, and HDL inhibit the proliferation of hematopoietic stem and multipotential progenitor cells and connect expansion of these populations with leukocytosis and accelerated atherosclerosis...
- Lipoproteins of bacterial pathogensA Kovacs-Simon
Room 416, School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, Devon, United Kingdom EX4 4QD
Infect Immun 79:548-61. 2011Bacterial lipoproteins are a set of membrane proteins with many different functions...
- Host defenses against Staphylococcus aureus infection require recognition of bacterial lipoproteinsJuliane Bubeck Wardenburg
Department of Microbiology, University of Chicago, Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 103:13831-6. 2006..aureus variants lacking lipoproteins escape immune recognition and cause lethal infections with disseminated abscess formation, failing to elicit an ..
- Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunityAlejandro Gallardo-Soler
Departamento de Bioquimica y Biologia Molecular y Genetica, Universidad de Extremadura Avenida de la Universidad s n, 10071 Caceres, Spain
Mol Endocrinol 22:1394-402. 2008..The uptake of modified lipoproteins is an important early event in the development of atherosclerosis...
- High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolismPasi Soininen
NMR Metabonomics Laboratory, Laboratory of Chemistry, Department of Biosciences, University of Kuopio, Kuopio, Finland
Analyst 134:1781-5. 2009..In contradiction to single 'biomarkers', the application of this holistic NMR approach and the integrated computational methods provides a data-driven systems biology approach to biomedical research...
- Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosisStephen J Nicholls
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
JAMA 297:499-508. 2007..However, no data exist describing the relationship between statin-induced changes in high-density lipoprotein cholesterol (HDL-C) and disease progression...
- Unique lipoprotein phenotype and genotype associated with exceptional longevityNir Barzilai
Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, New York, NY 10461, USA
JAMA 290:2030-40. 2003..Individuals with exceptional longevity have a lower incidence and/or significant delay in the onset of age-related disease, and their family members may inherit biological factors that modulate aging processes and disease susceptibility...
- ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulationMatthew A Kennedy
Department of Biological Chemistry, CHS 33 257, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
Cell Metab 1:121-31. 2005..Finally, we show that cholesterol efflux to HDL specifically requires ABCG1, whereas efflux to apoA1 requires ABCA1. These studies identify Abcg1 as a key gene involved in both cholesterol efflux to HDL and in tissue lipid homeostasis...
- Non-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in menTobias Pischon
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Circulation 112:3375-83. 2005Apolipoprotein B (apoB) plasma levels reflect the concentration of proatherogenic lipoproteins very low-density lipoprotein and low-density lipoprotein (LDL), whereas non-high-density lipoprotein cholesterol (non-HDL-C) levels reflect the ..
- RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteinsAntje Blumenthal
Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
Cell Host Microbe 5:35-46. 2009..LPS recognition and that RP105 positively regulates macrophage responses to Mycobacterium tuberculosis (Mtb) lipoproteins. Mtb-infected RP105(-/-) mice exhibited impaired proinflammatory cytokine responses associated with enhanced ..
- Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-β-1,6-N-acetylglucosamineRebekah Henry
Department of Microbiology, Monash University, Clayton, Australia
Antimicrob Agents Chemother 56:59-69. 2012..Taken together, these data show that, in response to total LPS loss, A. baumannii alters the expression of critical transport and biosynthesis systems associated with modulating the composition and structure of the bacterial surface...
- ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretionGregory A Graf
McDermott Center for Human Growth and Development and Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390, USA
J Biol Chem 278:48275-82. 2003..Finally, adenoviral expression of G2 in the presence or absence of G5 or G8 failed to promote sterol excretion into bile. These experiments indicate that G5 and G8 function as obligate heterodimers to promote sterol excretion into bile...
- Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control studyMatthew J McQueen
Population Health Research Institute and McMaster University, Hamilton, ON, Canada
Lancet 372:224-33. 2008Whether lipoproteins are better markers than lipids and lipoproteins for coronary heart disease is widely debated. Our aim was to compare the apolipoproteins and cholesterol as indices for risk of acute myocardial infarction.
- Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamstersAgnes M Rimando
Natural Products Utilization Research Unit, ARS, U S Department of Agriculture, Mississippi 38677, USA
J Agric Food Chem 53:3403-7. 2005..In vivo studies demonstrate that pterostilbene possesses lipid and glucose lowering effects...
- GPIHBP1 is responsible for the entry of lipoprotein lipase into capillariesBrandon S J Davies
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Cell Metab 12:42-52. 2010The lipolytic processing of triglyceride-rich lipoproteins by lipoprotein lipase (LPL) is the central event in plasma lipid metabolism, providing lipids for storage in adipose tissue and fuel for vital organs such as the heart...
- Host defense mechanisms triggered by microbial lipoproteins through toll-like receptorsH D Brightbill
Department of Microbiology and Immunology, Howard Hughes Medical Institute, University of California Los Angeles School of Medicine, Los Anges, CA 90095, USA
Science 285:732-6. 1999..Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like ..
- Plasma lipoproteins: genetic influences and clinical implicationsRobert A Hegele
Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, 406 100 Perth Drive, London, Ontario, Canada N6A 5K8
Nat Rev Genet 10:109-21. 2009..growing global public health problem of cardiovascular disease is associated with levels of plasma lipids and lipoproteins. Several experimental strategies have helped us to clarify the genetic architecture of these complex traits, ..
- Staphylococcus aureus deficient in lipidation of prelipoproteins is attenuated in growth and immune activationHartmut Stoll
Mikrobielle Genetik, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
Infect Immun 73:2411-23. 2005..In the wild type, the majority of [14C]palmitate-labeled lipoproteins were located in the membrane fraction, although some lipoproteins were also present on the cell surface and in ..
- The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogensTroy Bankhead
Department of Biochemistry, University of Calgary, Calgary, Alberta T2N 4 N1, Canada
Mol Microbiol 65:1547-58. 2007..Data are also presented that cast doubt on an immune evasion mechanism whereby VlsE directly masks other surface antigens similar to what has been observed for several other pathogens that undergo recombinational antigenic variation...
- Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: a comparison of older with young menN Karaouzene
Department of Molecular and Cellular Biology, Faculty of Sciences, University Abou Bekr Belkaid, Tlemcen, Algeria
Nutr Metab Cardiovasc Dis 21:792-9. 2011In this study, plasma lipids, lipoproteins and markers of oxidant/antioxidant status were investigated in young (n = 45) and older (n = 40) obese men and compared to those in young (n = 65) and older (n = 55) normal weight controls...
- Lipoprotein sorting in bacteriaSuguru Okuda
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Annu Rev Microbiol 65:239-59. 2011Bacterial lipoproteins are synthesized as precursors in the cytoplasm and processed into mature forms on the cytoplasmic membrane. A lipid moiety attached to the N terminus anchors these proteins to the membrane surface...
- Effects of ethanol intake on lipoproteins and atherosclerosisEliot A Brinton
Department of Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
Curr Opin Lipidol 21:346-51. 2010..This article reviews published studies regarding effects of ethanol intake on lipoprotein levels and function as they relate to atherosclerosis, with special emphasis on recent publications in the past 2 years...
- Possible contributions of lipoproteins and cholesterol to the pathogenesis of diabetes mellitus type 2Arnold von Eckardstein
Institute of Clinical Chemistry, University and University Hospital Zurich, Switzerland
Curr Opin Lipidol 22:26-32. 2011..We discuss the recent findings on the effects of lipoproteins and cholesterol on the function and survival of pancreatic β-cells as well as on obesity and insulin ..
- Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and betaJoyce J Repa
Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 75390, USA
J Biol Chem 277:18793-800. 2002..The addition of ABCG5 and ABCG8 to the growing list of LXR target genes further supports the notion that LXRs serve as sterol sensors to coordinately regulate sterol catabolism, storage, efflux, and elimination...
- The Echinococcus granulosus antigen B gene family comprises at least 10 unique genes in five subclasses which are differentially expressedWenbao Zhang
Molecular Parasitology Laboratory, Infectious Diseases Division, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
PLoS Negl Trop Dis 4:e784. 2010..It is generally accepted that EgAgB is comprised of a gene family of five subfamilies which are highly polymorphic, but the actual number of genes present is unknown...
- Smoking and smoking cessation -- the relationship between cardiovascular disease and lipoprotein metabolism: a reviewSara Chelland Campbell
Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306 1493, USA
Atherosclerosis 201:225-35. 2008..This review examines the current literature related to: (1) smoking, lipoproteins, and lipid-related enzymes; (2) the impact of nicotine, carbon monoxide and free radicals on physiologic ..
- Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectivelyK Lu
Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA
Am J Hum Genet 69:278-90. 2001..Identification of sterolin-1 and sterolin-2 as critical players in the regulation of dietary-sterol absorption and excretion identifies a new pathway of sterol transport...
- Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?Fumikazu Okajima
Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi, Japan
Biochim Biophys Acta 1582:132-7. 2002..Furthermore, S1P content in LDL was markedly decreased during its oxidation. This paper will discuss whether S1P is an atherogenic mediator or an anti-atherogenic mediator...
- The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposityStéphane Mandard
Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
J Biol Chem 281:934-44. 2006..The composite data suggest that via physical association with plasma lipoproteins, FIAF acts as a powerful signal from fat and other tissues to prevent fat storage and stimulate fat ..
- Lipoprotein subfractions and cardiovascular disease riskRonald M Krauss
Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
Curr Opin Lipidol 21:305-11. 2010..This review summarizes the properties of the major LDL and HDL particle subclasses, and recent evidence linking their measurement with risk of atherosclerosis and CVD...
- Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterolLiqing Yu
Department of Molecular Genetics and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9046, USA
J Clin Invest 110:671-80. 2002....
- Molecular cross-talk in host-parasite relationships: the intriguing immunomodulatory role of Echinococcus antigen B in cystic echinococcosisAlessandra Siracusano
Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Int J Parasitol 38:1371-6. 2008..Besides focusing on findings that provide intriguing insights into the complex interplay between host and parasite, we suggest how this information could extend the current therapeutic options in inflammatory diseases...
- Apolipoprotein E: far more than a lipid transport proteinR W Mahley
Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California 94141 9100, USA
Annu Rev Genomics Hum Genet 1:507-37. 2000..Functional differences in the apoE isoforms that affect (or did affect) survival before the reproductive years probably account, at least in part, for the allele frequencies of the present day...
- Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonanceW Timothy Garvey
Division of Endocrinology and Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
Diabetes 52:453-62. 2003..It will be important to study whether NMR lipoprotein subclass parameters can be used to manage risk more effectively and prevent cardiovascular disease in patients with the IRS...
- Role of lipids, lipoproteins and vitamins in women with breast cancerG Ray
Department of Biosciences, Jamia Millia Islamia, 110025, New Delhi, India
Clin Biochem 34:71-6. 2001..Lipids, lipoproteins and antioxidative vitamins have been associated with the risk of breast cancer...
- The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL))M Dobiasova
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Clin Biochem 34:583-8. 2001..To evaluate if logarithm of the ratio of plasma concentration of triglycerides to HDL-cholesterol (Log[TG/HDL-C]) correlates with cholesterol esterification rates in apoB-lipoprotein-depleted plasma (FER(HDL)) and lipoprotein particle size...
- Trends in serum lipids and lipoproteins of adults, 1960-2002Margaret D Carroll
National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
JAMA 294:1773-81. 2005....
- Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureusMasahito Hashimoto
Department of Nanostructure and Advanced Materials, Kagoshima University, Kagoshima, Japan
J Immunol 177:3162-9. 2006..However, we previously demonstrated that LTA fraction prepared from bacterial cells contains lipoproteins, which activate cells via TLR2...
- Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cellsAkio Kawakami
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Circulation 113:691-700. 2006b>Lipoproteins containing apolipoprotein (apo) CIII predict coronary heart disease and associate with components of the metabolic syndrome. ApoCIII inhibits lipoprotein catabolism in plasma...
- Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'emMatthew I Hutchings
School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
Trends Microbiol 17:13-21. 2009Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins...
- Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterolJelske N van der Veen
Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands
J Biol Chem 284:19211-9. 2009..This pathway is sensitive to pharmacological activation of the LXR system. These data support the concept that the intestine substantially contributes to reverse cholesterol transport...
- Identification of Francisella tularensis lipoproteins that stimulate the toll-like receptor (TLR) 2/TLR1 heterodimerShalini Thakran
Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Biol Chem 283:3751-60. 2008..Here we report the identification of two Francisella lipoproteins, TUL4 and FTT1103, which activate TLR2...
- Why is non-high-density lipoprotein cholesterol a better marker of the risk of vascular disease than low-density lipoprotein cholesterol?Allan Sniderman
Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Room H7 22, Royal Vic Hosp, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
J Clin Lipidol 4:152-5. 2010..Rather, non-HDL-C appears to be an indirect way of estimating apoB. We argue that we should integrate the information from non-HDL-C and apoB for better risk assessment and a better target of therapy...
- Dissecting the complete lipoprotein biogenesis pathway in Streptomyces scabiesDavid A Widdick
School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
Mol Microbiol 80:1395-412. 2011Following translocation, bacterial lipoproteins are lipidated by lipoprotein diacylglycerol transferase (Lgt) and cleaved of their signal peptides by lipoprotein signal peptidase (Lsp)...
- Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology FoundationJohn D Brunzell
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, and the Northwest Lipid Laboratory, University of Washington, Seattle, Washington, USA
Diabetes Care 31:811-22. 2008
- The cholesterol content of Western diets plays a major role in the paradoxical increase in high-density lipoprotein cholesterol and upregulates the macrophage reverse cholesterol transport pathwayJoan Carles Escola-Gil
Institut d Investigacions Biomèdiques Sant Pau, Barcelona, Spain
Arterioscler Thromb Vasc Biol 31:2493-9. 2011..The present study aimed to determine the effects of this Western-type diet on high-density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT) from macrophages to feces...
- Exercise, lipids, and lipoproteins in older adults: a meta-analysisGeorge A Kelley
Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506, USA
Prev Cardiol 8:206-14. 2005The authors used the meta-analytic approach to examine the effects of aerobic exercise on lipids and lipoproteins in adults 50 years of age and older...
- Lipid and lipoprotein profile in physiological pregnancyGiuseppe Lippi
Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita di Verona, Italy
Clin Lab 53:173-7. 2007..associated with a broad series of metabolic adaptations which may also influence the metabolism of lipids and lipoproteins. Although the modification of serum lipids and lipoproteins has been exhaustively investigated during and after ..
- Lipid disorders in type 1 diabetesB Verges
Service d endocrinologie, de diabétologie et des maladies métaboliques, Hopital du Bocage, Dijon, France
Diabetes Metab 35:353-60. 2009Patients with type 1 diabetes (T1D) also present with lipid disorders. Quantitative abnormalities of lipoproteins are observed in T1D patients with poor glycaemic control (increased plasma triglycerides and low-density lipoprotein [LDL] ..
- Alkylresorcinols from whole-grain wheat and rye are transported in human plasma lipoproteinsAnna Maria Linko-Parvinen
Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, Division of Clinical Chemistry, University of Helsinki, FIN 00014 Helsinki, Finland
J Nutr 137:1137-42. 2007..Plasma alkylresorcinols are transported in lipoproteins with VLDL and HDL being the main carriers...
- Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorptionM H Lee
Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina, USA
Nat Genet 27:79-83. 2001..H.L. et al., manuscript submitted). We now report that a new member of the ABC transporter family, ABCG5, is mutant in nine unrelated sitosterolemia patients...
- Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopyLei Zhang
Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
J Lipid Res 52:175-84. 2011..Lipoprotein structure-function relationships provide important clues that help identify the role of lipoproteins in cardiovascular disease...
- NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protectionBerenice Barajas
Department of Medicine, University of California, Center for Health Sciences, Los Angeles, CA 90095, USA
Arterioscler Thromb Vasc Biol 31:58-66. 2011..To test the hypothesis that NF-E2-related factor 2 (Nrf2) expression plays an antiatherogenic role by its vascular antioxidant and anti-inflammatory properties...
- Ethnic differences in serum lipoproteins and their determinants in South African womenJulia H Goedecke
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, 7700 South Africa
Metabolism 59:1341-50. 2010..The major determinants of serum lipids in black women were socioeconomic status and lifestyle factors, whereas in white women, S(I) and body composition most closely correlated with serum lipids...
- Crystal structure of Escherichia coli BamB, a lipoprotein component of the β-barrel assembly machinery complexKelly H Kim
Department of Molecular Biology and Biochemistry, Simon Fraser University, South Science Building, 8888 University Drive, Burnaby, British Columbia, Canada
J Mol Biol 406:667-78. 2011..The BAM complex in Escherichia coli consists of five proteins: one β-barrel membrane protein, BamA, and four lipoproteins, BamB, BamC, BamD, and BamE...
- Crossveinless d is a vitellogenin-like lipoprotein that binds BMPs and HSPGs, and is required for normal BMP signaling in the Drosophila wingJun Chen
Department of Zoology, University of Wisconsin Madison, Madison, WI 53706, USA
Development 139:2170-6. 2012....
- SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDLLaurent Yvan-Charvet
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA
J Lipid Res 49:107-14. 2008..Previous findings of increased atherosclerosis in mice transplanted with SR-BI(-/-) bone marrow probably cannot be explained by a defect in macrophage cholesterol efflux...
- ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysisLily Jakulj
Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Lipid Res 51:3016-23. 2010..Hence, associations between frequently studied missense ABCG5/G8 polymorphisms and markers of cholesterol homeostasis are modest at best...
- Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouseShu Wang
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Atherosclerosis 204:147-55. 2009..These data suggest that lower omega-6:EPA+DHA ratio diets lowered some measures of inflammation and Mphi cholesterol accumulation, which was associated with less aortic lesion formation in LDLr-/- mice...
- The metabolism of triglyceride-rich lipoproteins revisited: new players, new insightGeesje M Dallinga-Thie
Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
Atherosclerosis 211:1-8. 2010..In this review, we will provide an overview of novel data on both peripheral TG hydrolysis and hepatic remnant clearance that will improve our knowledge of plasma triglyceride metabolism...
- Kinetic control of TolC recruitment by multidrug efflux complexesElena B Tikhonova
Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Room 208, Norman, OK 73019, USA
Proc Natl Acad Sci U S A 106:16416-21. 2009..We propose that recruitment of TolC by various MFPs is determined not only by kinetics of MFP-TolC interactions but also by oligomerization kinetics of MFPs and pH...
- Patched regulates Smoothened trafficking using lipoprotein-derived lipidsHelena Khaliullina
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Development 136:4111-21. 2009..Here, we show that Drosophila Ptc recruits internalized lipoproteins to Ptc-positive endosomes and that its sterol-sensing domain regulates trafficking of both lipids and Smo from ..
- Effects of high-density lipoproteins on pancreatic beta-cell insulin secretionMichelle A Fryirs
The Heart Research Institute, Sydney, New South Wales, Australia
Arterioscler Thromb Vasc Biol 30:1642-8. 2010..Given the current interest in therapeutic interventions that raise HDLs levels, this study investigates the effects of HDLs on insulin secretion from beta-cells...
- Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapibLaurent Yvan-Charvet
Division of Molecular Medicine, Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
Arterioscler Thromb Vasc Biol 30:1430-8. 2010....
- Definition of the bacterial N-glycosylation site consensus sequenceMichael Kowarik
Institute of Microbiology, Department of Biology, Swiss Federal Institute of Technology Zurich, ETH Honggerberg, Switzerland
EMBO J 25:1957-66. 2006..Thus, bacterial N-glycosylation site selection is more specific than the eukaryotic equivalent with respect to the polypeptide acceptor sequence...
- Assembly and channel opening in a bacterial drug efflux machineVassiliy N Bavro
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
Mol Cell 30:114-21. 2008..We suggest that the assembly of multidrug efflux pumps is accompanied by induced fit of TolC driven mainly by accommodation of the periplasmic component...
- Lipoprotein synthesis in mycobacteriaMandana Rezwan
Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 32, CH 8006 Zurich, Switzerland
Microbiology 153:652-8. 2007b>Lipoproteins are a functionally diverse class of secreted bacterial proteins characterized by an N-terminal lipid moiety. The lipid moiety serves to anchor these proteins to the cell surface...
- The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferiXiaofeng F Yang
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
Proc Natl Acad Sci U S A 100:11001-6. 2003..a two-component sensory transduction system, is a pivotal regulator governing the expression of major membrane lipoproteins such as OspC, DbpA, and Mlp8, as well as many other mammalian infection-associated immunogens of Bb...
- Novel aspects of postprandial lipemia in relation to atherosclerosisA Alipour
Department of Internal Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands
Atheroscler Suppl 9:39-44. 2008..The atherogenic mechanisms of postprandial lipids and lipoproteins can be divided into direct lipoprotein-mediated and indirect effects; the latter, in part, by inducing an ..
- A detailed molecular belt model for apolipoprotein A-I in discoidal high density lipoproteinJ P Segrest
Department of Medicine, University of Alabama Birmingham Medical Center, Birmingham, Alabama 35294, USA
J Biol Chem 274:31755-8. 1999..The resulting model is an antiparallel arrangement with an alignment matching that of the (nonplanar) crystal structure of lipid-free apoA-I...
- Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trialsJ C LaRosa
Office of the President, State University of New York Health Science Center at Brooklyn, 11203, USA
JAMA 282:2340-6. 1999..Lowering low-density lipoprotein cholesterol (LDL-C) is known to reduce risk of recurrent coronary heart disease in middle-aged men. However, this effect has been uncertain in elderly people and women...
- Identification of immunodominant B- and T-cell combined epitopes in outer membrane lipoproteins LipL32 and LipL21 of Leptospira interrogansXu Ai Lin
Department of Medical Microbiology and Parasitology, School of Medicine, Zhejiang University, Hangzhou 310058, China
Clin Vaccine Immunol 17:778-83. 2010..LipL32 and LipL21 are the conserved outer membrane lipoproteins of L. interrogans and are considered vaccine candidates...
- Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in miceKristin I Stanford
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0687, USA
J Clin Invest 119:3236-45. 2009..In mice, accumulation of triglyceride-rich lipoproteins can occur if sulfation of heparan sulfate in hepatocytes is diminished, as this alters hepatic lipoprotein ..
- Remnant lipoproteins and atherogenesisAkio Kawakami
Department of Geriatrics and Vascular Medicine, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima D809, Bunkyo ku, Tokyo, Japan
J Atheroscler Thromb 12:73-6. 2005..triglyceride (TG) levels are closely related to atherosclerosis, independently of serum levels of high-density lipoproteins (HDL) and low-density lipoproteins (LDL)...
- Funnel-like hexameric assembly of the periplasmic adapter protein in the tripartite multidrug efflux pump in gram-negative bacteriaYongbin Xu
Department of Manufacturing Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 609 735, Republic of Korea
J Biol Chem 286:17910-20. 2011....
- AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux ComplexElena B Tikhonova
Department of Chemistry and Biochemistry, University of Oklahoma, Norman, 73019, USA
J Biol Chem 279:32116-24. 2004..We show that antibiotics, the substrates of AcrAB-TolC, stabilize interactions within the complex. However, the formation of the AcrAB-TolC complex does not require an input of energy...
- TAT-pathway-dependent lipoproteins as a niche-based adaptation in prokaryotesHamsanathan Shruthi
Centre for Biotechnology, Anna University, Chennai 600 025, Tamil Nadu, India
J Mol Evol 70:359-70. 2010Bacterial lipoproteins, characterized by the N-terminal N-acyl S-diacylglyceryl Cysteine, are key membrane proteins in bacterial homeostasis...
- Recent insights into factors affecting remnant lipoprotein uptakeKevin Jon Williams
Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
Curr Opin Lipidol 21:218-28. 2010Remnant lipoproteins that persist in the bloodstream after each meal have become increasingly important contributors to atherosclerotic vascular disease, owing to the spread of overnutrition, underexertion, obesity, insulin resistance, ..
- Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2Michael G Drage
Department of Pathology, Case Western Reserve University University Hospitals Case Medical Center, Cleveland, Ohio, USA
Nat Struct Mol Biol 17:1088-95. 2010..In conclusion, we demonstrate a glycolipid binding function of LprG that enhances recognition of triacylated MTB glycolipids by TLR2 and may affect glycolipid assembly or transport for bacterial cell wall biogenesis...
- Lipoprotein lipase bound to apolipoprotein B lipoproteins accelerates clearance of postprandial lipoproteins in humansChunyu Zheng
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Arterioscler Thromb Vasc Biol 26:891-6. 2006Experiments in cells and animal models show that lipoprotein lipase (LpL) bound to apolipoprotein (apo)B lipoproteins enhances their uptake by receptor mediated pathways. It is unknown whether this pathway is important in humans.
- Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophagesPreetha Shridas
Graduate Center for Nutritional Sciences, Saha Cardiovascular Research Center, University of Kentucky Medical Center, Lexington 40536 0200, USA
Arterioscler Thromb Vasc Biol 30:2014-21. 2010....
- Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitusEric A Schwartz
Department of Endocrinology, Phoenix VA Health Care System, 650 E Indian School Road 111E, Phoenix, AZ 85012 1892, USA
Atherosclerosis 212:217-22. 2010..Therefore, the effect of a single injection of exenatide on postprandial lipids, remnant lipoproteins, and apolipoproteins was studied.
- Conformational flexibility in the multidrug efflux system protein AcrAJonathan Mikolosko
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92037, USA
Structure 14:577-87. 2006..Notably, unsuspected conformational flexibility in the alpha-helical hairpin domain of AcrA is observed, which has potential mechanistic significance in coupling between AcrA conformations and TolC channel opening...
- Sequential mechanism of assembly of multidrug efflux pump AcrAB-TolCElena B Tikhonova
Department of Chemistry and Biochemistry, Stephenson Life Science Research Center, University of Oklahoma, Norman, OK 73019, USA
Chem Biol 18:454-63. 2011..The conformation of the membrane proximal domain of AcrA is critical for the formation of AcrAB-TolC and could be targeted for the development of new inhibitors...
- An analytical method for size and shape characterization of blood lipoproteinsDiana Cristina Rambaldi
Department of Chemistry G Ciamician, Bologna, Italy
Clin Chem 53:2026-9. 2007
- Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver diseaseElisa Fabbrini
Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
Gastroenterology 134:424-31. 2008..The purpose of this study was to evaluate TG metabolism in adipose tissue and liver in NAFLD...
- Staphylococcus aureus lipoproteins trigger human corneal epithelial innate response through toll-like receptor-2Qiong Li
Kresge Eye Institute Department of Ophthalmology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Microb Pathog 44:426-34. 2008Bacterial lipoproteins (LP) are a family of cell wall components found in a wide variety of bacteria...
- Atherogenesis and the humoral immune response to modified lipoproteinsGabriel Virella
Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, United States
Atherosclerosis 200:239-46. 2008..There is no conclusive evidence supporting a protective role for IgM antibodies in humans, possibly because autoantibodies to modified lipoproteins are predominantly of the IgG isotype.
- New insights into the molecular actions of plant sterols and stanols in cholesterol metabolismLaura Calpe-Berdiel
Servei de Bioquimica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Atherosclerosis 203:18-31. 2009..This article reviews the progress to date in studying these effects of phytosterols/phytostanols and the molecular mechanisms involved...
- Avoiding toxicity associated with MTP ablationM Mahmood Hussain; Fiscal Year: 2010High plasma lipids and lipoproteins are risk factors for various cardiovascular and metabolic disorders...
- Apo E mimetics reduce cholesterol and improve HDL functionG M Anantharamaiah; Fiscal Year: 2010..This proposal deals with ways of incorporating properties of lowering plasma apolipoprotein B- containing lipoproteins with properties of improving HDL function...
- BONE MARROW TRANSPLANTION AND ATHEROSCLEROSISMacRae Linton; Fiscal Year: 1999..The majority of apoE in the plasma lipoproteins is of hepatic origin, and the relative contribution of extrahepatic apoE to the metabolism of the plasma ..
- Mechanisms of ethanol-induced neurodevelopmental effectsMarina Guizzetti; Fiscal Year: 2009..brain, cholesterol is mostly produced endogenously, and its homeostasis is regulated by endogenously produced lipoproteins and cholesterol transporters...
- Mechanisms of ethanol-induced neurodevelopmental effectsMarina Guizzetti; Fiscal Year: 2010..brain, cholesterol is mostly produced endogenously, and its homeostasis is regulated by endogenously produced lipoproteins and cholesterol transporters...
- Role of Genes in Exceptional Longevity in HumansNir Barzilai; Fiscal Year: 2007..In addition, the Administrative Core is charged with maintaining relationships and contact with enrolled subjects, which is critical to the success of the longitudinal study design. ..
- A novel peroxidase in vascular endothelium and the development of atherosclerosisGuangjie Cheng; Fiscal Year: 2010..Aim #2 will investigate the oxidative modification of lipoproteins and lipids by VPO. The ability of purified VPO to oxidize LDL lipoprotein and lipid will be emphasized...
- APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISMLawrence Chan; Fiscal Year: 2004DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
- Structural Thermodynamics of Human Apolipoprotein C-1Olga Gursky; Fiscal Year: 2003..determine in molecular detail the energetic-structure-function relationship in exchangeable apolipoproteins and lipoproteins, thereby providing an insight into molecular mechanisms of lipoprotein action in the pathogenesis of ..
- Endoplasmic reticulum stress and foam cell formationZhongmao Guo; Fiscal Year: 2010..Similarly, ApoE-deficient (ApoE-/-) mice elevate plasma ApoB48-carrying lipoproteins and develop atherosclerosis in a manner that resembles the human disease...
- Structural Thermodynamics of Human Apolipoprotein C-1Olga Gursky; Fiscal Year: 2007..determine in molecular detail the energetic-structure-function relationship in exchangeable apolipoproteins and lipoproteins, thereby providing an insight into molecular mechanisms of lipoprotein action in the pathogenesis of ..
- Structural Thermodynamics of Human Apolipoprotein C-1Olga Gursky; Fiscal Year: 2006..determine in molecular detail the energetic-structure-function relationship in exchangeable apolipoproteins and lipoproteins, thereby providing an insight into molecular mechanisms of lipoprotein action in the pathogenesis of ..
- Pathogenesis of Lyme Borreliosis in the Rhesus MonkeyMARIO PHILIPP; Fiscal Year: 2007..The secondary hypothesis is that spirochetal lipoproteins can induce, in part or in toto, the inflammatory effects of B. burgdorferi...
- Endoplasmic reticulum stress and foam cell formationZhongmao Guo; Fiscal Year: 2009..Similarly, ApoE-deficient (ApoE-/-) mice elevate plasma ApoB48-carrying lipoproteins and develop atherosclerosis in a manner that resembles the human disease...
- PROTEASE INHIBITOR RELATED DYSLIPIDEMIAChristine Wanke; Fiscal Year: 2004..in the constantly fed state and deuterated leucine, the secretion and catabolism of apoB-48 and apoB-100 within lipoproteins will be determined by GC/MS analysis and multicompartmental modeling in the presence or absence of protease ..
- Nanoparticle Brain Delivery of Iron Chelators for ADGang Liu; Fiscal Year: 2007..will be determined by the 2-dimensional gel analysis, and indicate the capabilities of the systems to mimic lipoproteins. Kinetic studies of the particle delivery systems bi-directionally across Brain Blood Barrier (BBB) will be ..
- Nanoparticle Brain Delivery of Iron Chelators for ADGang Liu; Fiscal Year: 2010..will be determined by the 2-dimensional gel analysis, and indicate the capabilities of the systems to mimic lipoproteins. Kinetic studies of the particle delivery systems bi-directionally across Brain Blood Barrier (BBB) will be ..
- Nanoparticle Brain Delivery of Iron Chelators for ADGang Liu; Fiscal Year: 2009..will be determined by the 2-dimensional gel analysis, and indicate the capabilities of the systems to mimic lipoproteins. Kinetic studies of the particle delivery systems bi-directionally across Brain Blood Barrier (BBB) will be ..
- DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISKERNST SCHAEFER; Fiscal Year: 2003..Obesity increases CHD risk by adversely affecting glucose, lipoproteins, and blood pressure...
- Pharmacogenetics of the Statin ResponseERNST SCHAEFER; Fiscal Year: 2006..These results can be used to formulate guidelines for identifying elderly subjects for statin treatment to prevent future CHD. ..
- ASSEMBLY PATHWAY OF VLDL--A THREE STEP PROCESSLARRY SWIFT; Fiscal Year: 2001..Two steps occur in the rough endoplasmic reticulum (ER), producing triglyceride-rich lipoproteins. The third step involves addition of triglyceride and phospholipid to the maturing particle and occurs as the ..
- Quantitation of Tocopherol Metabolism in HumansAndrew Clifford; Fiscal Year: 2009..The null hypothesis is that EHT-a-TOC eliminated through "reverse cholesterol transfer." Plasma lipoproteins play key roles in delivering RRR-a-TOC to and from EHT...
- Quantitation of Tocopherol Metabolism in HumansANDREW JOSEPH CLIFFORD; Fiscal Year: 2010..The null hypothesis is that EHT-a-TOC eliminated through "reverse cholesterol transfer." Plasma lipoproteins play key roles in delivering RRR-a-TOC to and from EHT...
- ATHEROSCLEROSIS AND PERIPHERAL APOPROTEIN E SYNTHESISDavid Williams; Fiscal Year: 1993..The plasma concentrations of these lipoproteins are important factors in the development of atherosclerotic heart disease.
- ATHEROSCLEROSIS AND PERIPHERAL APOPROTEIN E SYNTHESISDavid Williams; Fiscal Year: 1999..These studies are designed to evaluate the importance of localized apoE expression on tissue cholesterol metabolism and steroidogenesis in normal adrenocortical cells in vivo and in culture. ..
- INTESTINAL LIPOPROTEINS IN THE NEONATEDennis Black; Fiscal Year: 2007..the following specific hypotheses: a) the enhancement of lipid secretion is due to increased size of secreted lipoproteins, and the particles have a normal complement of other apolipoproteins; b) absorbed fatty acid type (chain length ..
- Macrophage-lipoprotein interactionsFrederick R Maxfield; Fiscal Year: 2010Atherosclerosis results in part from the accumulation of lipoproteins in the arterial wall, recruitment of monocytes/macrophages to the region, and formation of lipid-laden macrophages, known as foam cells...
- LIPID AND LIPOPROTEIN METABOLISM IN INSECTSMichael Wells; Fiscal Year: 1993..Whereas vertebrates rely on a battery of lipoproteins to effect lipid transport, insects use primarily a single type of lipoprotein, LIPOPHORIN, for lipid transport...
- GHIHBP1 and the Metabolism of Triglyceride-Rich LipoproteinsStephen Young; Fiscal Year: 2009..we have made a stunning observation-that GPIHBP1 plays a major role in the metabolism of triglyceride-rich lipoproteins in the plasma...
- GHIHBP1 and the Metabolism of Triglyceride-Rich LipoproteinsStephen Young; Fiscal Year: 2007..we have made a stunning observation-that GPIHBP1 plays a major role in the metabolism of triglyceride-rich lipoproteins in the plasma...