Genomes and Genes
Summary: Any of the lipid-protein complexes in which lipids are transported in the blood. Lipoprotein particles consist of a spherical hydrophobic core of triglycerides or cholesteryl esters surrounded by an amphipathic monolayer of phospholipids, cholesterol, and apolipoproteins. (From Dorland, 27th ed)
Publications311 found, 100 shown here
- The protein moiety of Brucella abortus outer membrane protein 16 is a new bacterial pathogen-associated molecular pattern that activates dendritic cells in vivo, induces a Th1 immune response, and is a promising self-adjuvanting vaccine against systemic aKarina A Pasquevich
Laboratory of Immunogenetics, Clinical Hospital José de San Martín, School of Medicine, University of Buenos Aires, Buenos Aires
J Immunol 184:5200-12. 2010Knowing the inherent stimulatory properties of the lipid moiety of bacterial lipoproteins, we first hypothesized that Brucella abortus outer membrane protein (Omp)16 lipoprotein would be able to elicit a protective immune response without ..
- Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver diseaseKerry L Donnelly
Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St Paul, Minnesota, 55108, USA
J Clin Invest 115:1343-51. 2005..These quantitative metabolic data document that both elevated peripheral fatty acids and DNL contribute to the accumulation of hepatic and lipoprotein fat in NAFLD...
- Effects of the amount and intensity of exercise on plasma lipoproteinsWilliam E Kraus
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
N Engl J Med 347:1483-92. 2002..However, the amount of exercise training required for optimal benefit is unknown. In a prospective, randomized study, we investigated the effects of the amount and intensity of exercise on lipoproteins.
- Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and womenBørge G Nordestgaard
Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
JAMA 298:299-308. 2007Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis.
- Diabetic dyslipidaemia: from basic research to clinical practiceM R Taskinen
Department of Medicine, Division of Cardiology, University of Helsinki, Helsinki, Finland
Diabetologia 46:733-49. 2003The recognition that the increase of plasma triglyceride rich lipoproteins (TRLs) is associated with multiple alterations of other lipoproteins species that are potentially atherogenic has expanded the picture of diabetic dyslipidaemia...
- Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: a comparison of older with young menN Karaouzene
Department of Molecular and Cellular Biology, Faculty of Sciences, University Abou Bekr Belkaid, Tlemcen, Algeria
Nutr Metab Cardiovasc Dis 21:792-9. 2011In this study, plasma lipids, lipoproteins and markers of oxidant/antioxidant status were investigated in young (n = 45) and older (n = 40) obese men and compared to those in young (n = 65) and older (n = 55) normal weight controls...
- Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-β-1,6-N-acetylglucosamineRebekah Henry
Department of Microbiology, Monash University, Clayton, Australia
Antimicrob Agents Chemother 56:59-69. 2012..Taken together, these data show that, in response to total LPS loss, A. baumannii alters the expression of critical transport and biosynthesis systems associated with modulating the composition and structure of the bacterial surface...
- Lipoprotein particles are required for Hedgehog and Wingless signallingDaniela Panàkovà
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Nature 435:58-65. 2005..Similarly, the range of Wingless signalling is narrowed. We propose a novel function for lipoprotein particles, in which they act as vehicles for the movement of lipid-linked morphogens and glycophosphatidylinositol-linked proteins...
- ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulationMatthew A Kennedy
Department of Biological Chemistry, CHS 33 257, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
Cell Metab 1:121-31. 2005..Finally, we show that cholesterol efflux to HDL specifically requires ABCG1, whereas efflux to apoA1 requires ABCA1. These studies identify Abcg1 as a key gene involved in both cholesterol efflux to HDL and in tissue lipid homeostasis...
- Non-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in menTobias Pischon
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Circulation 112:3375-83. 2005Apolipoprotein B (apoB) plasma levels reflect the concentration of proatherogenic lipoproteins very low-density lipoprotein and low-density lipoprotein (LDL), whereas non-high-density lipoprotein cholesterol (non-HDL-C) levels reflect the ..
- Ethnic differences in serum lipoproteins and their determinants in South African womenJulia H Goedecke
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, 7700 South Africa
Metabolism 59:1341-50. 2010..The major determinants of serum lipids in black women were socioeconomic status and lifestyle factors, whereas in white women, S(I) and body composition most closely correlated with serum lipids...
- Detailed analysis of sequence changes occurring during vlsE antigenic variation in the mouse model of Borrelia burgdorferi infectionLoic Coutte
Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas, United States of America
PLoS Pathog 5:e1000293. 2009....
- Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in miceLaurent Yvan-Charvet
Division of Molecular Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Invest 117:3900-8. 2007..These results suggest that the combined effects of ABCA1 and ABCG1 in mediating macrophage sterol efflux are central to the antiatherogenic properties of HDL...
- Echinococcus granulosus antigen B impairs human dendritic cell differentiation and polarizes immature dendritic cell maturation towards a Th2 cell responseRachele Riganò
Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Infect Immun 75:1667-78. 2007..granulosus-stimulated DC maturation. These results suggest that E. granulosus escapes host immunosurveillance in two ways: by interfering with monocyte differentiation and by modulating DC maturation...
- Discrimination of bacterial lipoproteins by Toll-like receptor 6O Takeuchi
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
Int Immunol 13:933-40. 2001Bacterial lipoproteins (BLP) trigger immune responses via Toll-like receptor 2 (TLR2) and their immunostimulatory properties are attributed to the presence of a lipoylated N-terminus...
- Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coliTao Wu
Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
Cell 121:235-45. 2005..These genetic interactions suggest a role for YfgL, one of the lipoprotein components of the protein assembly complex, in a homeostatic control mechanism that coordinates the overall OM assembly process...
- Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunityAlejandro Gallardo-Soler
Departamento de Bioquimica y Biologia Molecular y Genetica, Universidad de Extremadura Avenida de la Universidad s n, 10071 Caceres, Spain
Mol Endocrinol 22:1394-402. 2008..The uptake of modified lipoproteins is an important early event in the development of atherosclerosis...
- Host defenses against Staphylococcus aureus infection require recognition of bacterial lipoproteinsJuliane Bubeck Wardenburg
Department of Microbiology, University of Chicago, Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 103:13831-6. 2006..aureus variants lacking lipoproteins escape immune recognition and cause lethal infections with disseminated abscess formation, failing to elicit an ..
- ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferationLaurent Yvan-Charvet
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
Science 328:1689-93. 2010..The findings indicate that ABCA1, ABCG1, and HDL inhibit the proliferation of hematopoietic stem and multipotential progenitor cells and connect expansion of these populations with leukocytosis and accelerated atherosclerosis...
- Lipoproteins of bacterial pathogensA Kovacs-Simon
Room 416, School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, Devon, United Kingdom EX4 4QD
Infect Immun 79:548-61. 2011Bacterial lipoproteins are a set of membrane proteins with many different functions...
- Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosisStephen J Nicholls
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
JAMA 297:499-508. 2007..However, no data exist describing the relationship between statin-induced changes in high-density lipoprotein cholesterol (HDL-C) and disease progression...
- Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trialsRonald P Mensink
Department of Human Biology, Maastricht University, Maastricht, Netherlands
Am J Clin Nutr 77:1146-55. 2003..Fats, however, also affect HDL cholesterol, and the ratio of total to HDL cholesterol is a more specific marker of CAD than is LDL cholesterol...
- High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolismPasi Soininen
NMR Metabonomics Laboratory, Laboratory of Chemistry, Department of Biosciences, University of Kuopio, Kuopio, Finland
Analyst 134:1781-5. 2009..In contradiction to single 'biomarkers', the application of this holistic NMR approach and the integrated computational methods provides a data-driven systems biology approach to biomedical research...
- Active efflux of bile salts by Escherichia coliD G Thanassi
Department of Molecular and Cell Biology, University of California, Berkeley 94720 3206, USA
J Bacteriol 179:2512-8. 1997..It followed saturation kinetics with Vmax and Km values in the neighborhood of 0.3 nmol min(-1) mg of protein(-1) and 50 microM, respectively...
- NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protectionBerenice Barajas
Department of Medicine, University of California, Center for Health Sciences, Los Angeles, CA 90095, USA
Arterioscler Thromb Vasc Biol 31:58-66. 2011..To test the hypothesis that NF-E2-related factor 2 (Nrf2) expression plays an antiatherogenic role by its vascular antioxidant and anti-inflammatory properties...
- Lipoproteins in bacteria: structures and biosynthetic pathwaysHiroshi Nakayama
Biomolecular Characterization Team, RIKEN Advanced Science Institute, Wako, Saitama, Japan
FEBS J 279:4247-68. 2012Bacterial lipoproteins are characterized by the presence of a conserved N-terminal lipid-modified cysteine residue that allows the hydrophilic protein to anchor onto bacterial cell membranes...
- Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamstersAgnes M Rimando
Natural Products Utilization Research Unit, ARS, U S Department of Agriculture, Mississippi 38677, USA
J Agric Food Chem 53:3403-7. 2005..In vivo studies demonstrate that pterostilbene possesses lipid and glucose lowering effects...
- Induction of direct antimicrobial activity through mammalian toll-like receptorsS Thoma-Uszynski
Division of Dermatology, Department of Microbiology and Immunology and Molecular Biology Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
Science 291:1544-7. 2001..Thus, mammalian TLRs respond (as Drosophila Toll receptors do) to microbial ligands and also have the ability to activate antimicrobial effector pathways at the site of infection...
- RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteinsAntje Blumenthal
Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
Cell Host Microbe 5:35-46. 2009..LPS recognition and that RP105 positively regulates macrophage responses to Mycobacterium tuberculosis (Mtb) lipoproteins. Mtb-infected RP105(-/-) mice exhibited impaired proinflammatory cytokine responses associated with enhanced ..
- Unique lipoprotein phenotype and genotype associated with exceptional longevityNir Barzilai
Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, New York, NY 10461, USA
JAMA 290:2030-40. 2003..Individuals with exceptional longevity have a lower incidence and/or significant delay in the onset of age-related disease, and their family members may inherit biological factors that modulate aging processes and disease susceptibility...
- Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sexM Cnop
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151 and University of Washington, 1660 S Columbian Way, Seattle, WA 98108, USA
Diabetologia 46:459-69. 2003..We investigated the relationships between adiponectin and leptin, body fat distribution, insulin sensitivity and lipoproteins.
- Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretionLiqing Yu
McDermott Center for Human Growth and Development and Departments of Molecular Genetics and Biochemistry, The Howard Hughes Medical Institute and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 99:16237-42. 2002....
- Crystal structures of a multidrug transporter reveal a functionally rotating mechanismSatoshi Murakami
Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
Nature 443:173-9. 2006..The voluminous binding pocket is aromatic and allows multi-site binding. The structures indicate that drugs are exported by a three-step functionally rotating mechanism in which substrates undergo ordered binding change...
- Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in miceRafael Prados-Rosales
Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York 10461, USA
J Clin Invest 121:1471-83. 2011..These findings may open up new horizons for understanding the pathogenesis of tuberculosis and developing vaccines...
- The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogensTroy Bankhead
Department of Biochemistry, University of Calgary, Calgary, Alberta T2N 4 N1, Canada
Mol Microbiol 65:1547-58. 2007..Data are also presented that cast doubt on an immune evasion mechanism whereby VlsE directly masks other surface antigens similar to what has been observed for several other pathogens that undergo recombinational antigenic variation...
- GPIHBP1 is responsible for the entry of lipoprotein lipase into capillariesBrandon S J Davies
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Cell Metab 12:42-52. 2010The lipolytic processing of triglyceride-rich lipoproteins by lipoprotein lipase (LPL) is the central event in plasma lipid metabolism, providing lipids for storage in adipose tissue and fuel for vital organs such as the heart...
- Plasma lipoproteins: genetic influences and clinical implicationsRobert A Hegele
Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, 406 100 Perth Drive, London, Ontario, Canada N6A 5K8
Nat Rev Genet 10:109-21. 2009..growing global public health problem of cardiovascular disease is associated with levels of plasma lipids and lipoproteins. Several experimental strategies have helped us to clarify the genetic architecture of these complex traits, ..
- Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver diseaseDaniel J Felmlee
INSERM, U1110, Institute of Virology, Strasbourg 67000, France
Viruses 5:1292-324. 2013..on hepatic very-low-density lipoprotein (VLDL) assembly, and circulating virions are physically associated with lipoproteins in complexes termed lipoviral particles...
- Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control studyMatthew J McQueen
Population Health Research Institute and McMaster University, Hamilton, ON, Canada
Lancet 372:224-33. 2008Whether lipoproteins are better markers than lipids and lipoproteins for coronary heart disease is widely debated. Our aim was to compare the apolipoproteins and cholesterol as indices for risk of acute myocardial infarction.
- Host defense mechanisms triggered by microbial lipoproteins through toll-like receptorsH D Brightbill
Department of Microbiology and Immunology, Howard Hughes Medical Institute, University of California Los Angeles School of Medicine, Los Anges, CA 90095, USA
Science 285:732-6. 1999..Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like ..
- Effects of smoking and smoking cessation on lipids and lipoproteins: outcomes from a randomized clinical trialAdam D Gepner
University of Wisconsin Schoolof Medicine and Public Health, Madison, WI 53792, USA
Am Heart J 161:145-51. 2011the effects of smoking and smoking cessation on lipoproteins have not been studied in a large contemporary group of smokers. This study was designed to determine the effects of smoking cessation on lipoproteins.
- Identification and localization of Myxococcus xanthus porins and lipoproteinsSwapna Bhat
Department of Microbiology, University of Georgia, Athens, Georgia, United States of America
PLoS ONE 6:e27475. 2011..Another class of membrane proteins, the lipoproteins, are anchored in the membrane via a lipid moiety at the N-terminus...
- The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposityStéphane Mandard
Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
J Biol Chem 281:934-44. 2006..The composite data suggest that via physical association with plasma lipoproteins, FIAF acts as a powerful signal from fat and other tissues to prevent fat storage and stimulate fat ..
- Lipoproteins in Drosophila melanogaster--assembly, function, and influence on tissue lipid compositionWilhelm Palm
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
PLoS Genet 8:e1002828. 2012Interorgan lipid transport occurs via lipoproteins, and altered lipoprotein levels correlate with metabolic disease. However, precisely how lipoproteins affect tissue lipid composition has not been comprehensively analyzed...
- Staphylococcus aureus deficient in lipidation of prelipoproteins is attenuated in growth and immune activationHartmut Stoll
Mikrobielle Genetik, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
Infect Immun 73:2411-23. 2005..In the wild type, the majority of [14C]palmitate-labeled lipoproteins were located in the membrane fraction, although some lipoproteins were also present on the cell surface and in ..
- Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and betaJoyce J Repa
Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 75390, USA
J Biol Chem 277:18793-800. 2002..The addition of ABCG5 and ABCG8 to the growing list of LXR target genes further supports the notion that LXRs serve as sterol sensors to coordinately regulate sterol catabolism, storage, efflux, and elimination...
- Lipoprotein sorting in bacteriaSuguru Okuda
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Annu Rev Microbiol 65:239-59. 2011Bacterial lipoproteins are synthesized as precursors in the cytoplasm and processed into mature forms on the cytoplasmic membrane. A lipid moiety attached to the N terminus anchors these proteins to the membrane surface...
- Effects of ethanol intake on lipoproteins and atherosclerosisEliot A Brinton
Department of Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
Curr Opin Lipidol 21:346-51. 2010..This article reviews published studies regarding effects of ethanol intake on lipoprotein levels and function as they relate to atherosclerosis, with special emphasis on recent publications in the past 2 years...
- Possible contributions of lipoproteins and cholesterol to the pathogenesis of diabetes mellitus type 2Arnold von Eckardstein
Institute of Clinical Chemistry, University and University Hospital Zurich, Switzerland
Curr Opin Lipidol 22:26-32. 2011..We discuss the recent findings on the effects of lipoproteins and cholesterol on the function and survival of pancreatic β-cells as well as on obesity and insulin ..
- A new on-line dual enzymatic method for simultaneous quantification of cholesterol and triglycerides in lipoproteins by HPLCShinichi Usui
Department of Biochemistry and Biophysics, Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
J Lipid Res 43:805-14. 2002..We conclude that the dual detection concept with proper choice of column and enzymic reagents specific to the objectives of the particular study can facilitate studies of lipoprotein metabolism...
- Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic menT A Mori
Department of Medicine, The University of Western Australia and The West Australian Heart Research Institute, Perth
Am J Clin Nutr 71:1085-94. 2000..Regular consumption of n-3 fatty acids of marine origin can improve serum lipids and reduce cardiovascular risk...
- Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stressTracie A Seimon
Department of Medicine, Columbia University, New York, NY 10032, USA
Cell Metab 12:467-82. 2010..These findings provide insight into how atherogenic lipoproteins trigger macrophage apoptosis in the setting of ER stress and how TLR activation might promote macrophage ..
- Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectivelyK Lu
Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA
Am J Hum Genet 69:278-90. 2001..Identification of sterolin-1 and sterolin-2 as critical players in the regulation of dietary-sterol absorption and excretion identifies a new pathway of sterol transport...
- Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?Fumikazu Okajima
Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi, Japan
Biochim Biophys Acta 1582:132-7. 2002..Furthermore, S1P content in LDL was markedly decreased during its oxidation. This paper will discuss whether S1P is an atherogenic mediator or an anti-atherogenic mediator...
- Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterolLiqing Yu
Department of Molecular Genetics and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9046, USA
J Clin Invest 110:671-80. 2002....
- Lipoprotein subfractions and cardiovascular disease riskRonald M Krauss
Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
Curr Opin Lipidol 21:305-11. 2010..This review summarizes the properties of the major LDL and HDL particle subclasses, and recent evidence linking their measurement with risk of atherosclerosis and CVD...
- Molecular cross-talk in host-parasite relationships: the intriguing immunomodulatory role of Echinococcus antigen B in cystic echinococcosisAlessandra Siracusano
Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Int J Parasitol 38:1371-6. 2008..Besides focusing on findings that provide intriguing insights into the complex interplay between host and parasite, we suggest how this information could extend the current therapeutic options in inflammatory diseases...
- Apolipoprotein E: far more than a lipid transport proteinR W Mahley
Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California 94141 9100, USA
Annu Rev Genomics Hum Genet 1:507-37. 2000..Functional differences in the apoE isoforms that affect (or did affect) survival before the reproductive years probably account, at least in part, for the allele frequencies of the present day...
- Role of lipids, lipoproteins and vitamins in women with breast cancerG Ray
Department of Biosciences, Jamia Millia Islamia, 110025, New Delhi, India
Clin Biochem 34:71-6. 2001..Lipids, lipoproteins and antioxidative vitamins have been associated with the risk of breast cancer...
- Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonanceW Timothy Garvey
Division of Endocrinology and Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
Diabetes 52:453-62. 2003..It will be important to study whether NMR lipoprotein subclass parameters can be used to manage risk more effectively and prevent cardiovascular disease in patients with the IRS...
- Structural basis of transfer between lipoproteins by cholesteryl ester transfer proteinLei Zhang
Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California, USA
Nat Chem Biol 8:342-9. 2012..transfer protein (CETP) mediates the net transfer of cholesteryl ester mass from atheroprotective high-density lipoproteins to atherogenic low-density lipoproteins by an unknown mechanism...
- TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferiUtpal Pal
Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Cell 119:457-68. 2004..Identification of an I. scapularis receptor for B. burgdorferi is the first step toward elucidating arthropod ligands that are required for survival of spirochetes in nature...
- Prediction of lipoprotein signal peptides in Gram-negative bacteriaAgnieszka S Juncker
Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby 2800, Denmark
Protein Sci 12:1652-62. 2003..The hidden Markov model (HMM) was able to distinguish between lipoproteins (SPaseII-cleaved proteins), SPaseI-cleaved proteins, cytoplasmic proteins, and transmembrane proteins...
- Pal lipoprotein of Escherichia coli plays a major role in outer membrane integrityEric Cascales
Laboratoire d Ingenierie des Systemes Macromoleculaires, Institut de Biologie Structurale et de Microbiologie, CNRS, UPR 9027, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
J Bacteriol 184:754-9. 2002..However, Pal was present in larger amounts compared to TolA and TolR proteins. The oligomeric state of Pal was determined and a new interaction between Pal and Lpp was demonstrated...
- Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family membersJennifer M MacArthur
Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California 92093 0687, USA
J Clin Invest 117:153-64. 2007..lacking only LDL receptors, suggesting that heparan sulfate participates in the clearance of cholesterol-rich lipoproteins as well...
- Influence of hepatic steatosis (fatty liver) on severity and composition of dyslipidemia in type 2 diabetesFrederico G S Toledo
Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, School of Medicine, Pennsylvania, USA
Diabetes Care 29:1845-50. 2006....
- Immunogenicity of a 2-dose priming and booster vaccination with the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccineSven Arne Silfverdal
Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden
Pediatr Infect Dis J 28:e276-82. 2009....
- ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretionGregory A Graf
McDermott Center for Human Growth and Development and Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390, USA
J Biol Chem 278:48275-82. 2003..Finally, adenoviral expression of G2 in the presence or absence of G5 or G8 failed to promote sterol excretion into bile. These experiments indicate that G5 and G8 function as obligate heterodimers to promote sterol excretion into bile...
- Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cellsAkio Kawakami
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Circulation 113:691-700. 2006b>Lipoproteins containing apolipoprotein (apo) CIII predict coronary heart disease and associate with components of the metabolic syndrome. ApoCIII inhibits lipoprotein catabolism in plasma...
- Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureusMasahito Hashimoto
Department of Nanostructure and Advanced Materials, Kagoshima University, Kagoshima, Japan
J Immunol 177:3162-9. 2006..However, we previously demonstrated that LTA fraction prepared from bacterial cells contains lipoproteins, which activate cells via TLR2...
- Trends in serum lipids and lipoproteins of adults, 1960-2002Margaret D Carroll
National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
JAMA 294:1773-81. 2005....
- Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'emMatthew I Hutchings
School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
Trends Microbiol 17:13-21. 2009Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins...
- Identification of Francisella tularensis lipoproteins that stimulate the toll-like receptor (TLR) 2/TLR1 heterodimerShalini Thakran
Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Biol Chem 283:3751-60. 2008..Here we report the identification of two Francisella lipoproteins, TUL4 and FTT1103, which activate TLR2...
- LipL21 is a novel surface-exposed lipoprotein of pathogenic Leptospira speciesPaul A Cullen
Bacterial Pathogenesis Research Group, Department of Microbiology, Monash University, Melbourne, Victoria 3800, Australia
Infect Immun 71:2414-21. 2003..These findings show that LipL21 is a surface-exposed, abundant outer membrane lipoprotein that is expressed during infection and conserved among pathogenic Leptospira species...
- Role of bile acids and bile acid receptors in metabolic regulationPhilippe Lefebvre
Institut National de la Sante et de la Recherche Medicale, Lille, France
Physiol Rev 89:147-91. 2009..Taken together, these findings suggest that modulation of FXR activity and BA metabolism may open new attractive pharmacological approaches for the treatment of the metabolic syndrome and type 2 diabetes...
- Temporal changes in outer surface proteins A and C of the lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and miceT G Schwan
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
J Clin Microbiol 38:382-8. 2000..Therefore, the temporal synthesis of OspC by spirochetes only in feeding ticks that were infected prior to the blood meal suggests that this surface protein is involved in transmission from tick to mammal but not from mammal to tick...
- Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pumpThamarai K Janganan
School of Biological and Biomedical Sciences, Durham University, South Road, Durham, DH1 3LE, UK
Mol Microbiol 88:590-602. 2013..Thus, our findings suggest that opening of the OMP via interaction with the MFP is energy-independent, while both drug export and complex dissociation require active proton flux...
- Fasting and nonfasting lipid levels: influence of normal food intake on lipids, lipoproteins, apolipoproteins, and cardiovascular risk predictionAnne Langsted
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
Circulation 118:2047-56. 2008..Lipid profiles are usually measured after fasting. We tested the hypotheses that these levels change only minimally in response to normal food intake and that nonfasting levels predict cardiovascular events...
- Effect of a low-carbohydrate, ketogenic diet program compared to a low-fat diet on fasting lipoprotein subclassesEric C Westman
Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
Int J Cardiol 110:212-6. 2006..Low-carbohydrate, ketogenic diets (LCKD) are effective for weight loss, but concerns remain regarding cardiovascular risk. The purpose of this study was to determine the effect of an LCKD program on serum lipoprotein subclasses...
- Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferiMing He
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mol Microbiol 70:1453-64. 2008Molecular mechanisms underlying the reciprocal regulation of the two major surface lipoproteins and virulence factors of Borrelia burgdorferi, OspA and OspC, are not fully understood...
- Lipoproteins and their receptors in embryonic development: more than cholesterol clearanceThomas E Willnow
Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, D 13125 Berlin, Germany
Development 134:3239-49. 2007Previously, the relevance of lipoproteins and their receptors has mainly been discussed in terms of cholesterol clearance in the adult organism...
- Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cellsA S Plump
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
Cell 71:343-53. 1992..This marked hypercholesterolemia is primarily due to elevated levels of very low and intermediate density lipoproteins. At 10 weeks of age, apoE-deficient mice have already developed atherosclerotic lesions in the aorta and ..
- Identification of novel members reveals the structural and functional divergence of lepidopteran-specific Lipoprotein_11 familyYan Zhang
State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China
Funct Integr Genomics 12:705-15. 2012..ENF-BP genes are expressed predominantly in the hemocyte. The differential spatial-temporal expression profiles revealed the functional divergence of three Lipoprotein_11 subfamilies...
- Why is non-high-density lipoprotein cholesterol a better marker of the risk of vascular disease than low-density lipoprotein cholesterol?Allan Sniderman
Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Room H7 22, Royal Vic Hosp, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
J Clin Lipidol 4:152-5. 2010..Rather, non-HDL-C appears to be an indirect way of estimating apoB. We argue that we should integrate the information from non-HDL-C and apoB for better risk assessment and a better target of therapy...
- Lipid disorders in type 1 diabetesB Verges
Service d endocrinologie, de diabétologie et des maladies métaboliques, Hopital du Bocage, Dijon, France
Diabetes Metab 35:353-60. 2009Patients with type 1 diabetes (T1D) also present with lipid disorders. Quantitative abnormalities of lipoproteins are observed in T1D patients with poor glycaemic control (increased plasma triglycerides and low-density lipoprotein [LDL] ..
- Dissecting the complete lipoprotein biogenesis pathway in Streptomyces scabiesDavid A Widdick
School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
Mol Microbiol 80:1395-412. 2011Following translocation, bacterial lipoproteins are lipidated by lipoprotein diacylglycerol transferase (Lgt) and cleaved of their signal peptides by lipoprotein signal peptidase (Lsp)...
- The cholesterol content of Western diets plays a major role in the paradoxical increase in high-density lipoprotein cholesterol and upregulates the macrophage reverse cholesterol transport pathwayJoan Carles Escola-Gil
Institut d Investigacions Biomèdiques Sant Pau, Barcelona, Spain
Arterioscler Thromb Vasc Biol 31:2493-9. 2011..The present study aimed to determine the effects of this Western-type diet on high-density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT) from macrophages to feces...
- Lipid and lipoprotein profile in physiological pregnancyGiuseppe Lippi
Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita di Verona, Italy
Clin Lab 53:173-7. 2007..associated with a broad series of metabolic adaptations which may also influence the metabolism of lipids and lipoproteins. Although the modification of serum lipids and lipoproteins has been exhaustively investigated during and after ..
- Exercise, lipids, and lipoproteins in older adults: a meta-analysisGeorge A Kelley
Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506, USA
Prev Cardiol 8:206-14. 2005The authors used the meta-analytic approach to examine the effects of aerobic exercise on lipids and lipoproteins in adults 50 years of age and older...
- Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology FoundationJohn D Brunzell
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, and the Northwest Lipid Laboratory, University of Washington, Seattle, Washington, USA
Diabetes Care 31:811-22. 2008
- SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDLLaurent Yvan-Charvet
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA
J Lipid Res 49:107-14. 2008..Previous findings of increased atherosclerosis in mice transplanted with SR-BI(-/-) bone marrow probably cannot be explained by a defect in macrophage cholesterol efflux...
- ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysisLily Jakulj
Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Lipid Res 51:3016-23. 2010..Hence, associations between frequently studied missense ABCG5/G8 polymorphisms and markers of cholesterol homeostasis are modest at best...
- Crystal structure of Escherichia coli BamB, a lipoprotein component of the β-barrel assembly machinery complexKelly H Kim
Department of Molecular Biology and Biochemistry, Simon Fraser University, South Science Building, 8888 University Drive, Burnaby, British Columbia, Canada
J Mol Biol 406:667-78. 2011..The BAM complex in Escherichia coli consists of five proteins: one β-barrel membrane protein, BamA, and four lipoproteins, BamB, BamC, BamD, and BamE...
- Alkylresorcinols from whole-grain wheat and rye are transported in human plasma lipoproteinsAnna Maria Linko-Parvinen
Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, Division of Clinical Chemistry, University of Helsinki, FIN 00014 Helsinki, Finland
J Nutr 137:1137-42. 2007..Plasma alkylresorcinols are transported in lipoproteins with VLDL and HDL being the main carriers...
- Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorptionM H Lee
Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina, USA
Nat Genet 27:79-83. 2001..H.L. et al., manuscript submitted). We now report that a new member of the ABC transporter family, ABCG5, is mutant in nine unrelated sitosterolemia patients...
- Crossveinless d is a vitellogenin-like lipoprotein that binds BMPs and HSPGs, and is required for normal BMP signaling in the Drosophila wingJun Chen
Department of Zoology, University of Wisconsin Madison, Madison, WI 53706, USA
Development 139:2170-6. 2012....
- Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopyLei Zhang
Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
J Lipid Res 52:175-84. 2011..Lipoprotein structure-function relationships provide important clues that help identify the role of lipoproteins in cardiovascular disease...
- Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapibLaurent Yvan-Charvet
Division of Molecular Medicine, Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
Arterioscler Thromb Vasc Biol 30:1430-8. 2010....
- Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouseShu Wang
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Atherosclerosis 204:147-55. 2009..These data suggest that lower omega-6:EPA+DHA ratio diets lowered some measures of inflammation and Mphi cholesterol accumulation, which was associated with less aortic lesion formation in LDLr-/- mice...
- Effects of high-density lipoproteins on pancreatic beta-cell insulin secretionMichelle A Fryirs
The Heart Research Institute, Sydney, New South Wales, Australia
Arterioscler Thromb Vasc Biol 30:1642-8. 2010..Given the current interest in therapeutic interventions that raise HDLs levels, this study investigates the effects of HDLs on insulin secretion from beta-cells...
- The metabolism of triglyceride-rich lipoproteins revisited: new players, new insightGeesje M Dallinga-Thie
Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
Atherosclerosis 211:1-8. 2010..In this review, we will provide an overview of novel data on both peripheral TG hydrolysis and hepatic remnant clearance that will improve our knowledge of plasma triglyceride metabolism...
- The Primate Corpus Luteum: Functional Regression and Cardiovascular ImpactsRandy L Bogan; Fiscal Year: 2012..E2 and P4 implants to simulate an artificial menstrual cycle and levels of high, low, and very-low density lipoproteins (HDL, LDL, VLDL, respectively) and triglycerides in serum will be measured as indicators of cardiovascular risk...
- MECHANISMS IN THE REGULATION OF SP-A GENE EXPRESSIONCarole R Mendelson; Fiscal Year: 2013....
- Pharmacogenetics of obesity and endocannabinergic modulation (POEM)Russell A Wilke; Fiscal Year: 2012..In the future, individual patients with variation in these genes may benefit from targeted behavioral and/or pharmacological interventions designed to improve their health. ..
- Comprehensive biomarker study to capitalize on existing GWAS in 10K South AsiansDanish Saleheen; Fiscal Year: 2010..We will assay markers of: (1) lipids and lipoproteins (apoA-I, apoA-II, apoB, apoC-III, apoE, lipoprotein(a), lipoprotein subclasses, oxidized phospholipids, ..
- Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junctionMartin A Smith; Fiscal Year: 2012..This novel signal pathway represents a new therapeutic target for the treatment of neuromuscular disease. ..
- Retinoid Metabolism and Alcohol Induced DiseaseWilliam S Blaner; Fiscal Year: 2010..We are proposing studies that will provide a more complete understanding of relationships between alcohol consumption, vitamin A metabolism and actions, and alcoholic organ damage. ..
- Hepatic Steatosis Modulation by Apo B Gene TranscriptionJANET DEHOFF SPARKS; Fiscal Year: 2010..apo) B synthesis through increased apob gene transcription which favors hepatic TG export in very low density lipoproteins (VLDL) and reduces liver TG content by 45%...
- A novel peroxidase in vascular endothelium and the development of atherosclerosisGuangjie Cheng; Fiscal Year: 2012..Aim #2 will investigate the oxidative modification of lipoproteins and lipids by VPO. The ability of purified VPO to oxidize LDL lipoprotein and lipid will be emphasized...
- Prolonged Inhibition of Pathologic Neovascularization by Catalytic AntioxidantsJAMES FRANCIS MCGINNIS; Fiscal Year: 2013....
- Thyroid Hormone ActionTHOMAS STERLING SCANLAN; Fiscal Year: 2013....
- Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol HomeostasisKamal D Mehta; Fiscal Year: 2010..The greatest potential for arresting this epidemic is likely to come through a clearer understanding of its molecular pathogenesis to develop rational and mechanism based therapy. ..
- Regulation of Hepatic SphK2 by Bile Acids: Effects on Lipid MetabolismHUIPING ROSE ZHOU; Fiscal Year: 2013..genes encoding enzymes/proteins involved in the metabolism/synthesis of bile acids, glucose, fatty acids, and lipoproteins as well as energy metabolism by activating specific nuclear receptors, a G protein coupled receptor (GPCR, TGR5)..
- Effects of Standardized Aerobic Exercise-Training on Neurocognitive and NeurodegeThomas O Obisesan; Fiscal Year: 2010....
- Characterization of new toxins (YmgD and YdfD) from E.coli, targeting cell wallHisako Masuda; Fiscal Year: 2012..Lol complex is responsible for translocating outer membrane lipoproteins, including Lpp, from inner the membrane to the outer membrane...
- Monocyte activation and the role of CD11c in obesity-linked metabolic syndromeHuaizhu Wu; Fiscal Year: 2013..by adipose tissue (AT) and liver-and with increased hepatic production of triglyceride-rich lipoproteins (TGRLs) and increased levels of fatty acids (FAs, saturated FAs in particular)...
- Cholesterol and Lymphatic Transport of Molecules and CellsMelody A Swartz; Fiscal Year: 2012Lymph is rich in lipids, including lipoproteins, and the return of cholesterol from tissues to the vasculature and ultimately the liver depends not only on the loading of cholesterol onto high-density lipoprotein (HDL) particles within ..
- The Impact of Obstructive Sleep Apnea on Non-Alcoholic Fatty Liver DiseaseKATHLEEN ELIZABETH COREY; Fiscal Year: 2013..in 8 first author publications including the identification of a two lipid biomarkers, oxidized low density lipoproteins (OxLDL) and non-high density lipoprotein cholesterol for NAFLD...
- MECHANISMS OF MILK LIPID SECRETIONJAMES LEWIS MCMANAMAN; Fiscal Year: 2013....
- Chemical Biology Studies of 3-Iodothyronamine and Related Thyroid Hormone MetabolTHOMAS STERLING SCANLAN; Fiscal Year: 2013..4) Determine the mechanism of intracellular uptake of T1AM and search for T1AM target proteins. ..
- Mechanisms of ethanol-induced neurodevelopmental effectsMarina Guizzetti; Fiscal Year: 2011..brain, cholesterol is mostly produced endogenously, and its homeostasis is regulated by endogenously produced lipoproteins and cholesterol transporters...
- The Postischemia Inflammatory Syndrome in the Aged KidneyKATHERINE JULIA KELLY; Fiscal Year: 2013..Nearly one-half of patient beginning dialysis for CKD were e65 yo. We propose to study inflammatory and vascular injury and cell death and the effects of potential therapies in a model of CKD. ..
- Development of a Porcine Model of AtherosclerosisChristopher Rogers; Fiscal Year: 2010..This animal model will provide academic and industrial research communities with an opportunity to better understand cardiovascular disease and its pathogenesis, and to develop and test new therapeutics and preventative strategies. ..
- Mechanisms of Obesity in Mice with Neuron-Specific Lipoprotein Lipase DeficiencyRobert H Eckel; Fiscal Year: 2013..is the rate limiting enzyme for the uptake of fatty acids from the hydrolysis of circulating triglyceride-rich lipoproteins for lipid storage and/or oxidation in peripheral tissues...
- Asthma Increases Vaso-occlusion in Sickle Cell DiseaseKirkwood A Pritchard; Fiscal Year: 2013..myeloperoxidase (MPO);3) cell free hemoglobin (Hb);and, 4) oxidized lipids prevents oxidation of HDL and other lipoproteins in the SCD mice with asthma...
- Regulation of Triglyceride Metabolism by the transcription factor CREB-HAnn Hwee Lee; Fiscal Year: 2013....
- Metabolic impact of fructose restriction in obese childrenJean Marc Schwarz; Fiscal Year: 2013..abstract_text> ..
- Adiponectin and fetal programmingJianhua Shao; Fiscal Year: 2013..These studies will reveal new pathways of fetal programming that will lead to new therapeutic approaches to stop the vicious cycle of maternal-offspring obesity. ..
- Metabolic Actions of Omega-3 Fatty Acids on InflammationMichael Miller; Fiscal Year: 2013..ALA supplementation on 1) Metabolic (e.g., lipoproteins, inflammatory cytokines, acute phase reactants, glucose tolerance/insulin resistance) and adipose tissue ..
- Adipose Tissue Macrophage Phenotype and FunctionAnthony W Ferrante; Fiscal Year: 2013....
- Regulation of factor VIII Levels and Activity by Members of LDL Receptor FamilyDudley K Strickland; Fiscal Year: 2013..endocytic receptor that plays an important role in the catabolism of several ligands including apoE-enriched lipoproteins, plasminogen activators, and serpin-enzyme complexes...
- Plasma Lipid Markers and Cancer RiskLu Wang; Fiscal Year: 2013....
- Development of a Porcine Model of AtherosclerosisChristopher Rogers; Fiscal Year: 2012..Thus, this work will accelerate the discovery of novel therapies for this costly and deadly disease. ..
- Hepatic Lipase and HCV InfectionTianyi Wang; Fiscal Year: 2010..Because it is known that HSPG mediates the initial HCV attachment and circulating HCV associates with lipoproteins, we hypothesize that elevated levels of HL and LPL may regulate the HCV infection and production in either cell-..
- Sphingosine 1-phosphate and cardioprotectionJOEL SAMUEL KARLINER; Fiscal Year: 2012..Secretion of S1P leads to extensive binding by albumin and plasma lipoproteins and circulation at nanomolar to micromolar concentrations...
- Regulation of Signaling Receptor Activity by LRP-1Steven L Gonias; Fiscal Year: 2013..PUBLIC HEALTH RELEVANCE: Low density lipoprotein receptor-related protein has emerged as an important regulator of inflammation and atherosclerosis. This proposal seeks to elucidate the responsible mechanisms. ..
- Lipoprotein Structure and Function by Individual Particle Electron TomographyGang Ren; Fiscal Year: 2013..Major risk factors for CVD are the plasma lipoprotein levels. Lipoproteins are classified according to their densities as high , low-, intermediate- and very low-density lipoproteins (..
- Group B. Streptococci and Toll-like ReceptorsDouglas T Golenbock; Fiscal Year: 2012..First, we have identified lipoproteins as endotoxins that constitute functional equivalents to the well defined lipopolysaccharide in Gram-negative ..
- Over-Expression of microRNA-126 in Macrophages for Treatment of AtherosclerosisSuzette Laing; Fiscal Year: 2013..In atherosclerosis, the earliest lesions contain macrophages that have phagocytized and accumulated modified lipoproteins. The continued monocyte recruitment and cholesterol accumulation in the vessel wall facilitates chronic disease ..
- Role of NPC1L1 in regulating energy metabolism, nutrient utilization & weight gaiPhilip N Howles; Fiscal Year: 2010..Preliminary studies into other physiological effects of ezetimibe have revealed that postprandial intestinal lipoproteins from ezetimibe-treated mice are different in size and composition than those from control mice...
- Optimal Selective Thyroid Hormone Analogs for Metabolic SyndromeJohn D Baxter; Fiscal Year: 2010..We will find drugs that will safely treat high cholesterol and obesity and work through one class of these proteins, thyroid hormone receptors. ..
- Interactions of Diesel Exhaust and Respiratory Viruses in Asthmatic ChildrenToby C Lewis; Fiscal Year: 2013..2 million people in the United States, thus pointing the way towards targeted therapies and public health approaches. ..
- IGF-1, bone turnover and response to teriparatide in premenopausal women with IOPAdi Cohen; Fiscal Year: 2013....
- Lipid Metabolism and Steatosis in LiverAmrita Kamat; Fiscal Year: 2013..The study is expected to have an important impact by defining new molecular targets for the prevention and/or treatment of NAFLD and its complications. ..
- Macrophage AMPK, Inflammation, and AtherosclerosisBingzhong Xue; Fiscal Year: 2013..Completing these studies will greatly improve our knowledge on the role of macrophage AMPK in the protection against inflammation-associated metabolic disorders, including atherosclerosis and insulin resistance. ..
- Avoiding toxicity associated with MTP ablationM Mahmood Hussain; Fiscal Year: 2013DESCRIPTION (provided by applicant): High plasma lipids and lipoproteins are risk factors for various cardiovascular and metabolic disorders...
- Tick Midgut Proteins Critical for Borrelia TransmissionSukanya Narasimhan; Fiscal Year: 2010..In this proposal we will identify tick midgut proteins that interact with Borrelia during spirochete growth and migration and examine the impact of this interaction on Borrelia growth in the tick and transmission to the murine host. ..
- Smooth muscle cell lipid metabolism and serum amyloid ABarbara M Schreiber; Fiscal Year: 2010..Serum amyloid A (SAA) accumulates in atherosclerotic plaques by deposition from plasma lipoproteins and/or local synthesis...
- Primate Fetal Adrenal Development: Impact on Physiological Processes After BirthEugene D Albrecht; Fiscal Year: 2013....
- Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBBConrad Earl Johanson; Fiscal Year: 2010..Translation: Ap is an expedient marker to analyze aging effects on ISF-CSF relationships, and the compromised solute clearance by malfunctioning barrier systems. This sheds light on neurodegeneration. ..
- Daily Experience in Adolescence and Biomarkers of Early Risk for Adult HealthAndrew J Fuligni; Fiscal Year: 2013..blood spots will be obtained for the assessment of c-reactive-protein (CRP), cholesterol, and high density lipoproteins (HDL)...
- Role of Lipoproteins in Chagasic heart diseaseJYOTHI FALGUNI NAGAJYOTHI; Fiscal Year: 2013..Serum lipoproteins such as LDL, very Low Density Lipoprotein (VLDL) and HDL likely play a major role in the progression of ..
- Novel mechanisms of niacin to improve HDL function: Role of myeloperoxidaseMoti L Kashyap; Fiscal Year: 2013DESCRIPTION (provided by applicant): Physiologically functional high density lipoproteins (HDL) are protective against development of atherosclerotic cardiovascular disease (CVD)...
- Plasminogen activators and NMDA after brain injuryWilliam M Armstead; Fiscal Year: 2012..Immunohistochemistry, detection of plasminogen activator and MAPK expression, and CBF determination by radiolabled microspheres will be performed. ..
- Quorum sensing regulation of EHEC virulence genesVanessa Sperandio; Fiscal Year: 2013..Specific Aim 2. To elucidate the post-transcriptional regulation of the LEE and espFu genes by the glmY sRNA. Specific Aim 3. To characterize the role of the lipoprotein QseG in attaching and effacing (AE) lesion formation. ..
- Shared Mechanisms of Valvular and Vascular CalcificationJOEL DAVID MORRISETT; Fiscal Year: 2012..aortic valves, porcine mitral valves, and various regions of human calcified aortic valves to bind plasma lipoproteins (Aim 3)...
- CELLS PROCESSING HIGH DENSITY LIPOPROTEINSSalman Azhar; Fiscal Year: 2013..Both bile acids and steroids are synthesized from SR-BI-mediated selectively delivered cholesterol, thus underscoring the relevance of understanding the cellular mechanisms controlling the functional expression of SR-BI. ..
- Metabolic Syndrome and PeriodontitisELIZABETH A KAYE; Fiscal Year: 2013..This proposed epidemiologic study is a timely and cost-effective means to better understand the relationship between periodontal disease and the metabolic syndrome. ..
- Eicosanoids and Endothelial Cell DysfunctionGadiparthi N Rao; Fiscal Year: 2013....
- CORONARY DISEASE MORBIDITY AND MORTALITY IN A POPULATIONVeronique L Roger; Fiscal Year: 2012..It will determine the importance of novel biomarkers to predict the risk of adverse events in clinical practice. ..
- RISK FACTORS FOR CVD IN WOMENJOANN ELISABETH MANSON; Fiscal Year: 2012..These promising biochemical and genetic markers may have implications for improving prevention strategies, enhancing treatment options, and generating additional testable hypotheses for heart disease research. ..
- The Magnesium and Metabolic Syndrome TrialStella Lucia Volpe; Fiscal Year: 2010..If effective in improving insulin resistance in the metabolic syndrome, magnesium supplementation could have a great public health impact by delaying or preventing type 2 diabetes mellitus, and also in decreasing health care costs. ..
- ENHANCEMENT OF CORONARY CONSTRICTION BY COMBUSTION-SOURCE AIR TOXICSMatthew J Campen; Fiscal Year: 2012..Results from these studies will assist in the assessment and management of personal risk of health effects from air pollution exposure. ..
- Epidemiology of Retinopathy and other Complications in Long Term Type 1 DiabetesMichael Y Tsai; Fiscal Year: 2013..These data will be important to patients and their physicians in developing new interventions for managing type 1 diabetes and to public health practitioners charged with delivering preventive care. ..
- Treatment of Acute Coronary Syndromes with Recombinant LCAT InfusionBRIAN ROBERT KRAUSE; Fiscal Year: 2011....
- APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISMLawrence Chan; Fiscal Year: 2004DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
- Antigenic variation by multiple promoter inversions in Mycoplasma penetransMichael Calcutt; Fiscal Year: 2009..penetrans-derived lipoproteins stimulate HIV-1 replication, raises the possibility that this Mycoplasma may be a contributory co-pathogen in ..
- Endoplasmic reticulum stress and foam cell formationZhongmao Guo; Fiscal Year: 2010..Similarly, ApoE-deficient (ApoE-/-) mice elevate plasma ApoB48-carrying lipoproteins and develop atherosclerosis in a manner that resembles the human disease...
- ASSEMBLY OF NASCENT PLASMA LIPOPROTEINS BY HEPATOCYTESRobert Hamilton; Fiscal Year: 1991..abstract): The long-term goals of this research are to determine the mechanisms by which hepatocytes secrete lipoproteins and apolipoproteins...
- Pathogenesis of Lyme Borreliosis in the Rhesus MonkeyMARIO PHILIPP; Fiscal Year: 2007..The secondary hypothesis is that spirochetal lipoproteins can induce, in part or in toto, the inflammatory effects of B. burgdorferi...
- APOE3 AND APOE4 EFFECTS ON CELLULAR PATHOBIOLOGYROBERT PITAS; Fiscal Year: 1999..Only apoE added to the cell with beta- migrating very low density lipoproteins (beta-VLDL) or lipid emulsions had an effect, and the effect was blocked by reductive methylation of apoE or by ..
- Nanoparticle Brain Delivery of Iron Chelators for ADGang Liu; Fiscal Year: 2010..will be determined by the 2-dimensional gel analysis, and indicate the capabilities of the systems to mimic lipoproteins. Kinetic studies of the particle delivery systems bi-directionally across Brain Blood Barrier (BBB) will be ..
- Pharmacogenetics of the Statin ResponseERNST SCHAEFER; Fiscal Year: 2006..These results can be used to formulate guidelines for identifying elderly subjects for statin treatment to prevent future CHD. ..
- DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISKERNST SCHAEFER; Fiscal Year: 2003..Obesity increases CHD risk by adversely affecting glucose, lipoproteins, and blood pressure...
- APOLIPOPROTEIN E BINDING TO RECEPTORSDavid Chappell; Fiscal Year: 1991The interaction of lipoproteins with lipoprotein receptors is a fundamental factor influencing the levels of plasma lipoproteins and delivery of lipids to tissues...
- Quantitation of Tocopherol Metabolism in HumansANDREW JOSEPH CLIFFORD; Fiscal Year: 2010..The null hypothesis is that EHT-a-TOC eliminated through "reverse cholesterol transfer." Plasma lipoproteins play key roles in delivering RRR-a-TOC to and from EHT...
- CORONARY ARTERY DISEASE AND POSTPRANDIAL LIPOPROTEINSHenry Ginsberg; Fiscal Year: 1992Epidemiologic evidence for an association between risk for developing CAD and fasting levels of plasma lipids, lipoproteins and apolipoproteins is derived from international cross-sectional data, prospective within-country population ..
- INTESTINAL LIPOPROTEINS IN THE NEONATEDennis Black; Fiscal Year: 2007..the following specific hypotheses: a) the enhancement of lipid secretion is due to increased size of secreted lipoproteins, and the particles have a normal complement of other apolipoproteins; b) absorbed fatty acid type (chain length ..
- LIPOPROTEIN LIPASE MODULATION OF TISSUE LIPID UPTAKEJOSEPH OBUNIKE; Fiscal Year: 1999..LPL) is the major enzyme responsible for hydrolysis of triglyceride (TG) molecules present in circulating lipoproteins. LPL is thought to interact with circulating lipoproteins while bound to cell surface glycosaminoglycans on the ..