lipoproteins

Summary

Summary: Any of the lipid-protein complexes in which lipids are transported in the blood. Lipoprotein particles consist of a spherical hydrophobic core of triglycerides or cholesteryl esters surrounded by an amphipathic monolayer of phospholipids, cholesterol, and apolipoproteins. (From Dorland, 27th ed)

Top Publications

  1. ncbi The protein moiety of Brucella abortus outer membrane protein 16 is a new bacterial pathogen-associated molecular pattern that activates dendritic cells in vivo, induces a Th1 immune response, and is a promising self-adjuvanting vaccine against systemic a
    Karina A Pasquevich
    Laboratory of Immunogenetics, Clinical Hospital José de San Martín, School of Medicine, University of Buenos Aires, Buenos Aires
    J Immunol 184:5200-12. 2010
  2. pmc Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    Kerry L Donnelly
    Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St Paul, Minnesota, 55108, USA
    J Clin Invest 115:1343-51. 2005
  3. ncbi Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    JAMA 298:299-308. 2007
  4. ncbi Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex
    M Cnop
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151 and University of Washington, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetologia 46:459-69. 2003
  5. pmc Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management
    M John Chapman
    European Atherosclerosis Society, INSERM UMR S939, Pitie Salpetriere University Hospital, Paris 75651, France
    Eur Heart J 32:1345-61. 2011
  6. ncbi Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    A S Plump
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
    Cell 71:343-53. 1992
  7. ncbi Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
    A O Aliprantis
    Skirball Institute and Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Science 285:736-9. 1999
  8. ncbi High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism
    Pasi Soininen
    NMR Metabonomics Laboratory, Laboratory of Chemistry, Department of Biosciences, University of Kuopio, Kuopio, Finland
    Analyst 134:1781-5. 2009
  9. ncbi TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi
    Utpal Pal
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 119:457-68. 2004
  10. ncbi Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
    Satoshi Murakami
    Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Nature 443:173-9. 2006

Detail Information

Publications277 found, 100 shown here

  1. ncbi The protein moiety of Brucella abortus outer membrane protein 16 is a new bacterial pathogen-associated molecular pattern that activates dendritic cells in vivo, induces a Th1 immune response, and is a promising self-adjuvanting vaccine against systemic a
    Karina A Pasquevich
    Laboratory of Immunogenetics, Clinical Hospital José de San Martín, School of Medicine, University of Buenos Aires, Buenos Aires
    J Immunol 184:5200-12. 2010
    Knowing the inherent stimulatory properties of the lipid moiety of bacterial lipoproteins, we first hypothesized that Brucella abortus outer membrane protein (Omp)16 lipoprotein would be able to elicit a protective immune response without ..
  2. pmc Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    Kerry L Donnelly
    Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St Paul, Minnesota, 55108, USA
    J Clin Invest 115:1343-51. 2005
    ..These quantitative metabolic data document that both elevated peripheral fatty acids and DNL contribute to the accumulation of hepatic and lipoprotein fat in NAFLD...
  3. ncbi Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    JAMA 298:299-308. 2007
    Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis.
  4. ncbi Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex
    M Cnop
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151 and University of Washington, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetologia 46:459-69. 2003
    ..We investigated the relationships between adiponectin and leptin, body fat distribution, insulin sensitivity and lipoproteins.
  5. pmc Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management
    M John Chapman
    European Atherosclerosis Society, INSERM UMR S939, Pitie Salpetriere University Hospital, Paris 75651, France
    Eur Heart J 32:1345-61. 2011
    ..This paper aims (i) to critically appraise evidence for elevated levels of triglyceride-rich lipoproteins (TRLs) and low levels of high-density lipoprotein cholesterol (HDL-C) as cardiovascular risk factors, and (ii) ..
  6. ncbi Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    A S Plump
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
    Cell 71:343-53. 1992
    ..This marked hypercholesterolemia is primarily due to elevated levels of very low and intermediate density lipoproteins. At 10 weeks of age, apoE-deficient mice have already developed atherosclerotic lesions in the aorta and ..
  7. ncbi Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
    A O Aliprantis
    Skirball Institute and Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Science 285:736-9. 1999
    ..All bacterial pathogens produce lipoproteins (BLPs), which trigger the innate immune response...
  8. ncbi High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism
    Pasi Soininen
    NMR Metabonomics Laboratory, Laboratory of Chemistry, Department of Biosciences, University of Kuopio, Kuopio, Finland
    Analyst 134:1781-5. 2009
    ..In contradiction to single 'biomarkers', the application of this holistic NMR approach and the integrated computational methods provides a data-driven systems biology approach to biomedical research...
  9. ncbi TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi
    Utpal Pal
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 119:457-68. 2004
    ..Identification of an I. scapularis receptor for B. burgdorferi is the first step toward elucidating arthropod ligands that are required for survival of spirochetes in nature...
  10. ncbi Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
    Satoshi Murakami
    Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Nature 443:173-9. 2006
    ..The voluminous binding pocket is aromatic and allows multi-site binding. The structures indicate that drugs are exported by a three-step functionally rotating mechanism in which substrates undergo ordered binding change...
  11. ncbi Effects of the amount and intensity of exercise on plasma lipoproteins
    William E Kraus
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 347:1483-92. 2002
    ..However, the amount of exercise training required for optimal benefit is unknown. In a prospective, randomized study, we investigated the effects of the amount and intensity of exercise on lipoproteins.
  12. ncbi Diabetic dyslipidaemia: from basic research to clinical practice
    M R Taskinen
    Department of Medicine, Division of Cardiology, University of Helsinki, Helsinki, Finland
    Diabetologia 46:733-49. 2003
    The recognition that the increase of plasma triglyceride rich lipoproteins (TRLs) is associated with multiple alterations of other lipoproteins species that are potentially atherogenic has expanded the picture of diabetic dyslipidaemia...
  13. ncbi Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: a comparison of older with young men
    N Karaouzene
    Department of Molecular and Cellular Biology, Faculty of Sciences, University Abou Bekr Belkaid, Tlemcen, Algeria
    Nutr Metab Cardiovasc Dis 21:792-9. 2011
    In this study, plasma lipids, lipoproteins and markers of oxidant/antioxidant status were investigated in young (n = 45) and older (n = 40) obese men and compared to those in young (n = 65) and older (n = 55) normal weight controls...
  14. pmc Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-β-1,6-N-acetylglucosamine
    Rebekah Henry
    Department of Microbiology, Monash University, Clayton, Australia
    Antimicrob Agents Chemother 56:59-69. 2012
    ..Taken together, these data show that, in response to total LPS loss, A. baumannii alters the expression of critical transport and biosynthesis systems associated with modulating the composition and structure of the bacterial surface...
  15. ncbi ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation
    Matthew A Kennedy
    Department of Biological Chemistry, CHS 33 257, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    Cell Metab 1:121-31. 2005
    ..Finally, we show that cholesterol efflux to HDL specifically requires ABCG1, whereas efflux to apoA1 requires ABCA1. These studies identify Abcg1 as a key gene involved in both cholesterol efflux to HDL and in tissue lipid homeostasis...
  16. ncbi Lipoprotein particles are required for Hedgehog and Wingless signalling
    Daniela Panàkovà
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Nature 435:58-65. 2005
    ..Similarly, the range of Wingless signalling is narrowed. We propose a novel function for lipoprotein particles, in which they act as vehicles for the movement of lipid-linked morphogens and glycophosphatidylinositol-linked proteins...
  17. ncbi A new on-line dual enzymatic method for simultaneous quantification of cholesterol and triglycerides in lipoproteins by HPLC
    Shinichi Usui
    Department of Biochemistry and Biophysics, Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Lipid Res 43:805-14. 2002
    ..We conclude that the dual detection concept with proper choice of column and enzymic reagents specific to the objectives of the particular study can facilitate studies of lipoprotein metabolism...
  18. ncbi Serum lipids and lipoproteins in Chinese men and women
    Wenying Yang
    Department of Endocrinology, China Japan Friendship Hospital, Beijing, China
    Circulation 125:2212-21. 2012
    Because of rapid change in lifestyle risk factors, cardiovascular disease has become the leading cause of death in China. We sought to estimate the national levels of serum lipids and lipoproteins among the Chinese adult population.
  19. pmc Detailed analysis of sequence changes occurring during vlsE antigenic variation in the mouse model of Borrelia burgdorferi infection
    Loic Coutte
    Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas, United States of America
    PLoS Pathog 5:e1000293. 2009
    ....
  20. pmc Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 117:3900-8. 2007
    ..These results suggest that the combined effects of ABCA1 and ABCG1 in mediating macrophage sterol efflux are central to the antiatherogenic properties of HDL...
  21. ncbi Ethnic differences in serum lipoproteins and their determinants in South African women
    Julia H Goedecke
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, 7700 South Africa
    Metabolism 59:1341-50. 2010
    ..The major determinants of serum lipids in black women were socioeconomic status and lifestyle factors, whereas in white women, S(I) and body composition most closely correlated with serum lipids...
  22. ncbi Non-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in men
    Tobias Pischon
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Circulation 112:3375-83. 2005
    Apolipoprotein B (apoB) plasma levels reflect the concentration of proatherogenic lipoproteins very low-density lipoprotein and low-density lipoprotein (LDL), whereas non-high-density lipoprotein cholesterol (non-HDL-C) levels reflect the ..
  23. pmc Echinococcus granulosus antigen B impairs human dendritic cell differentiation and polarizes immature dendritic cell maturation towards a Th2 cell response
    Rachele Riganò
    Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Infect Immun 75:1667-78. 2007
    ..granulosus-stimulated DC maturation. These results suggest that E. granulosus escapes host immunosurveillance in two ways: by interfering with monocyte differentiation and by modulating DC maturation...
  24. ncbi Plasma lipoproteins: apolipoprotein structure and function
    R W Mahley
    J Lipid Res 25:1277-94. 1984
    ....
  25. ncbi Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli
    Tao Wu
    Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
    Cell 121:235-45. 2005
    ..These genetic interactions suggest a role for YfgL, one of the lipoprotein components of the protein assembly complex, in a homeostatic control mechanism that coordinates the overall OM assembly process...
  26. ncbi Smoking and smoking cessation -- the relationship between cardiovascular disease and lipoprotein metabolism: a review
    Sara Chelland Campbell
    Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306 1493, USA
    Atherosclerosis 201:225-35. 2008
    ..This review examines the current literature related to: (1) smoking, lipoproteins, and lipid-related enzymes; (2) the impact of nicotine, carbon monoxide and free radicals on physiologic ..
  27. pmc Host defenses against Staphylococcus aureus infection require recognition of bacterial lipoproteins
    Juliane Bubeck Wardenburg
    Department of Microbiology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 103:13831-6. 2006
    ..aureus variants lacking lipoproteins escape immune recognition and cause lethal infections with disseminated abscess formation, failing to elicit an ..
  28. pmc ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Science 328:1689-93. 2010
    ..The findings indicate that ABCA1, ABCG1, and HDL inhibit the proliferation of hematopoietic stem and multipotential progenitor cells and connect expansion of these populations with leukocytosis and accelerated atherosclerosis...
  29. pmc Lipoproteins of bacterial pathogens
    A Kovacs-Simon
    Room 416, School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, Devon, United Kingdom EX4 4QD
    Infect Immun 79:548-61. 2011
    Bacterial lipoproteins are a set of membrane proteins with many different functions...
  30. ncbi Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity
    Alejandro Gallardo-Soler
    Departamento de Bioquimica y Biologia Molecular y Genetica, Universidad de Extremadura Avenida de la Universidad s n, 10071 Caceres, Spain
    Mol Endocrinol 22:1394-402. 2008
    ..The uptake of modified lipoproteins is an important early event in the development of atherosclerosis...
  31. ncbi Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis
    Stephen J Nicholls
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JAMA 297:499-508. 2007
    ..However, no data exist describing the relationship between statin-induced changes in high-density lipoprotein cholesterol (HDL-C) and disease progression...
  32. ncbi Lipoproteins in bacteria: structures and biosynthetic pathways
    Hiroshi Nakayama
    Biomolecular Characterization Team, RIKEN Advanced Science Institute, Wako, Saitama, Japan
    FEBS J 279:4247-68. 2012
    Bacterial lipoproteins are characterized by the presence of a conserved N-terminal lipid-modified cysteine residue that allows the hydrophilic protein to anchor onto bacterial cell membranes...
  33. ncbi Induction of direct antimicrobial activity through mammalian toll-like receptors
    S Thoma-Uszynski
    Division of Dermatology, Department of Microbiology and Immunology and Molecular Biology Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Science 291:1544-7. 2001
    ..Thus, mammalian TLRs respond (as Drosophila Toll receptors do) to microbial ligands and also have the ability to activate antimicrobial effector pathways at the site of infection...
  34. pmc Active efflux of bile salts by Escherichia coli
    D G Thanassi
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3206, USA
    J Bacteriol 179:2512-8. 1997
    ..It followed saturation kinetics with Vmax and Km values in the neighborhood of 0.3 nmol min(-1) mg of protein(-1) and 50 microM, respectively...
  35. ncbi The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL))
    M Dobiasova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Clin Biochem 34:583-8. 2001
    ..To evaluate if logarithm of the ratio of plasma concentration of triglycerides to HDL-cholesterol (Log[TG/HDL-C]) correlates with cholesterol esterification rates in apoB-lipoprotein-depleted plasma (FER(HDL)) and lipoprotein particle size...
  36. ncbi Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters
    Agnes M Rimando
    Natural Products Utilization Research Unit, ARS, U S Department of Agriculture, Mississippi 38677, USA
    J Agric Food Chem 53:3403-7. 2005
    ..In vivo studies demonstrate that pterostilbene possesses lipid and glucose lowering effects...
  37. pmc Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein
    Lei Zhang
    Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Nat Chem Biol 8:342-9. 2012
    ..transfer protein (CETP) mediates the net transfer of cholesteryl ester mass from atheroprotective high-density lipoproteins to atherogenic low-density lipoproteins by an unknown mechanism...
  38. pmc NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection
    Berenice Barajas
    Department of Medicine, University of California, Center for Health Sciences, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 31:58-66. 2011
    ..To test the hypothesis that NF-E2-related factor 2 (Nrf2) expression plays an antiatherogenic role by its vascular antioxidant and anti-inflammatory properties...
  39. ncbi Unique lipoprotein phenotype and genotype associated with exceptional longevity
    Nir Barzilai
    Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, New York, NY 10461, USA
    JAMA 290:2030-40. 2003
    ..Individuals with exceptional longevity have a lower incidence and/or significant delay in the onset of age-related disease, and their family members may inherit biological factors that modulate aging processes and disease susceptibility...
  40. pmc RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins
    Antje Blumenthal
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    Cell Host Microbe 5:35-46. 2009
    ..LPS recognition and that RP105 positively regulates macrophage responses to Mycobacterium tuberculosis (Mtb) lipoproteins. Mtb-infected RP105(-/-) mice exhibited impaired proinflammatory cytokine responses associated with enhanced ..
  41. pmc Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion
    Liqing Yu
    McDermott Center for Human Growth and Development and Departments of Molecular Genetics and Biochemistry, The Howard Hughes Medical Institute and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 99:16237-42. 2002
    ....
  42. ncbi Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study
    Matthew J McQueen
    Population Health Research Institute and McMaster University, Hamilton, ON, Canada
    Lancet 372:224-33. 2008
    Whether lipoproteins are better markers than lipids and lipoproteins for coronary heart disease is widely debated. Our aim was to compare the apolipoproteins and cholesterol as indices for risk of acute myocardial infarction.
  43. pmc Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice
    Rafael Prados-Rosales
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 121:1471-83. 2011
    ..These findings may open up new horizons for understanding the pathogenesis of tuberculosis and developing vaccines...
  44. ncbi The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens
    Troy Bankhead
    Department of Biochemistry, University of Calgary, Calgary, Alberta T2N 4 N1, Canada
    Mol Microbiol 65:1547-58. 2007
    ..Data are also presented that cast doubt on an immune evasion mechanism whereby VlsE directly masks other surface antigens similar to what has been observed for several other pathogens that undergo recombinational antigenic variation...
  45. ncbi Discrimination of bacterial lipoproteins by Toll-like receptor 6
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Int Immunol 13:933-40. 2001
    Bacterial lipoproteins (BLP) trigger immune responses via Toll-like receptor 2 (TLR2) and their immunostimulatory properties are attributed to the presence of a lipoylated N-terminus...
  46. pmc GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 12:42-52. 2010
    The lipolytic processing of triglyceride-rich lipoproteins by lipoprotein lipase (LPL) is the central event in plasma lipid metabolism, providing lipids for storage in adipose tissue and fuel for vital organs such as the heart...
  47. ncbi Plasma lipoproteins: genetic influences and clinical implications
    Robert A Hegele
    Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, 406 100 Perth Drive, London, Ontario, Canada N6A 5K8
    Nat Rev Genet 10:109-21. 2009
    ..growing global public health problem of cardiovascular disease is associated with levels of plasma lipids and lipoproteins. Several experimental strategies have helped us to clarify the genetic architecture of these complex traits, ..
  48. pmc Lipoproteins in Drosophila melanogaster--assembly, function, and influence on tissue lipid composition
    Wilhelm Palm
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    PLoS Genet 8:e1002828. 2012
    Interorgan lipid transport occurs via lipoproteins, and altered lipoprotein levels correlate with metabolic disease. However, precisely how lipoproteins affect tissue lipid composition has not been comprehensively analyzed...
  49. ncbi The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity
    Stéphane Mandard
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
    J Biol Chem 281:934-44. 2006
    ..The composite data suggest that via physical association with plasma lipoproteins, FIAF acts as a powerful signal from fat and other tissues to prevent fat storage and stimulate fat ..
  50. ncbi Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
    H D Brightbill
    Department of Microbiology and Immunology, Howard Hughes Medical Institute, University of California Los Angeles School of Medicine, Los Anges, CA 90095, USA
    Science 285:732-6. 1999
    ..Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like ..
  51. ncbi The central role of lipoproteins in the pathogenesis of mycoplasmoses
    G F Browning
    Asia Pacific Centre for Animal Health, Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria 3010, Australia
    Vet Microbiol 153:44-50. 2011
    ..of the biochemical functions and roles in virulence of another central feature of mycoplasmas, their lipoproteins, continues to develop...
  52. pmc Effects of smoking and smoking cessation on lipids and lipoproteins: outcomes from a randomized clinical trial
    Adam D Gepner
    University of Wisconsin Schoolof Medicine and Public Health, Madison, WI 53792, USA
    Am Heart J 161:145-51. 2011
    the effects of smoking and smoking cessation on lipoproteins have not been studied in a large contemporary group of smokers. This study was designed to determine the effects of smoking cessation on lipoproteins.
  53. pmc Identification and localization of Myxococcus xanthus porins and lipoproteins
    Swapna Bhat
    Department of Microbiology, University of Georgia, Athens, Georgia, United States of America
    PLoS ONE 6:e27475. 2011
    ..Another class of membrane proteins, the lipoproteins, are anchored in the membrane via a lipid moiety at the N-terminus...
  54. ncbi Lipoproteins and their receptors in embryonic development: more than cholesterol clearance
    Thomas E Willnow
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, D 13125 Berlin, Germany
    Development 134:3239-49. 2007
    Previously, the relevance of lipoproteins and their receptors has mainly been discussed in terms of cholesterol clearance in the adult organism...
  55. pmc Staphylococcus aureus deficient in lipidation of prelipoproteins is attenuated in growth and immune activation
    Hartmut Stoll
    Mikrobielle Genetik, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Infect Immun 73:2411-23. 2005
    ..In the wild type, the majority of [14C]palmitate-labeled lipoproteins were located in the membrane fraction, although some lipoproteins were also present on the cell surface and in ..
  56. ncbi Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta
    Joyce J Repa
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    J Biol Chem 277:18793-800. 2002
    ..The addition of ABCG5 and ABCG8 to the growing list of LXR target genes further supports the notion that LXRs serve as sterol sensors to coordinately regulate sterol catabolism, storage, efflux, and elimination...
  57. ncbi Lipoprotein sorting in bacteria
    Suguru Okuda
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Microbiol 65:239-59. 2011
    Bacterial lipoproteins are synthesized as precursors in the cytoplasm and processed into mature forms on the cytoplasmic membrane. A lipid moiety attached to the N terminus anchors these proteins to the membrane surface...
  58. pmc The Echinococcus granulosus antigen B gene family comprises at least 10 unique genes in five subclasses which are differentially expressed
    Wenbao Zhang
    Molecular Parasitology Laboratory, Infectious Diseases Division, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS Negl Trop Dis 4:e784. 2010
    ..It is generally accepted that EgAgB is comprised of a gene family of five subfamilies which are highly polymorphic, but the actual number of genes present is unknown...
  59. ncbi Effects of ethanol intake on lipoproteins and atherosclerosis
    Eliot A Brinton
    Department of Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Curr Opin Lipidol 21:346-51. 2010
    ..This article reviews published studies regarding effects of ethanol intake on lipoprotein levels and function as they relate to atherosclerosis, with special emphasis on recent publications in the past 2 years...
  60. ncbi Possible contributions of lipoproteins and cholesterol to the pathogenesis of diabetes mellitus type 2
    Arnold von Eckardstein
    Institute of Clinical Chemistry, University and University Hospital Zurich, Switzerland
    Curr Opin Lipidol 22:26-32. 2011
    ..We discuss the recent findings on the effects of lipoproteins and cholesterol on the function and survival of pancreatic β-cells as well as on obesity and insulin ..
  61. ncbi Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men
    T A Mori
    Department of Medicine, The University of Western Australia and The West Australian Heart Research Institute, Perth
    Am J Clin Nutr 71:1085-94. 2000
    ..Regular consumption of n-3 fatty acids of marine origin can improve serum lipids and reduce cardiovascular risk...
  62. ncbi Effect of a nutritional intervention promoting the Mediterranean food pattern on plasma lipids, lipoproteins and body weight in healthy French-Canadian women
    Julie Goulet
    Department of Food Sciences and Nutrition, Nutraceuticals and Functional Foods Institute, Laval University, Quebec, Quebec, Canada G1K 7P4
    Atherosclerosis 170:115-24. 2003
    ....
  63. pmc Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress
    Tracie A Seimon
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Cell Metab 12:467-82. 2010
    ..These findings provide insight into how atherogenic lipoproteins trigger macrophage apoptosis in the setting of ER stress and how TLR activation might promote macrophage ..
  64. pmc Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks
    J Ohnishi
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 98:670-5. 2001
    The genome of Borrelia burgdorferi encodes a large number of lipoproteins, many of which are expressed only at certain stages of the spirochete's life cycle. In the current study we describe the B...
  65. ncbi Molecular cross-talk in host-parasite relationships: the intriguing immunomodulatory role of Echinococcus antigen B in cystic echinococcosis
    Alessandra Siracusano
    Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Int J Parasitol 38:1371-6. 2008
    ..Besides focusing on findings that provide intriguing insights into the complex interplay between host and parasite, we suggest how this information could extend the current therapeutic options in inflammatory diseases...
  66. pmc Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol
    Liqing Yu
    Department of Molecular Genetics and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9046, USA
    J Clin Invest 110:671-80. 2002
    ....
  67. ncbi Lipoprotein subfractions and cardiovascular disease risk
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Curr Opin Lipidol 21:305-11. 2010
    ..This review summarizes the properties of the major LDL and HDL particle subclasses, and recent evidence linking their measurement with risk of atherosclerosis and CVD...
  68. ncbi Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?
    Fumikazu Okajima
    Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi, Japan
    Biochim Biophys Acta 1582:132-7. 2002
    ..Furthermore, S1P content in LDL was markedly decreased during its oxidation. This paper will discuss whether S1P is an atherogenic mediator or an anti-atherogenic mediator...
  69. pmc Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively
    K Lu
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA
    Am J Hum Genet 69:278-90. 2001
    ..Identification of sterolin-1 and sterolin-2 as critical players in the regulation of dietary-sterol absorption and excretion identifies a new pathway of sterol transport...
  70. ncbi Apolipoprotein E: far more than a lipid transport protein
    R W Mahley
    Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California 94141 9100, USA
    Annu Rev Genomics Hum Genet 1:507-37. 2000
    ..Functional differences in the apoE isoforms that affect (or did affect) survival before the reproductive years probably account, at least in part, for the allele frequencies of the present day...
  71. ncbi Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance
    W Timothy Garvey
    Division of Endocrinology and Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Diabetes 52:453-62. 2003
    ..It will be important to study whether NMR lipoprotein subclass parameters can be used to manage risk more effectively and prevent cardiovascular disease in patients with the IRS...
  72. ncbi Role of lipids, lipoproteins and vitamins in women with breast cancer
    G Ray
    Department of Biosciences, Jamia Millia Islamia, 110025, New Delhi, India
    Clin Biochem 34:71-6. 2001
    ..Lipids, lipoproteins and antioxidative vitamins have been associated with the risk of breast cancer...
  73. ncbi Influence of hepatic steatosis (fatty liver) on severity and composition of dyslipidemia in type 2 diabetes
    Frederico G S Toledo
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, School of Medicine, Pennsylvania, USA
    Diabetes Care 29:1845-50. 2006
    ....
  74. pmc Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members
    Jennifer M MacArthur
    Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California 92093 0687, USA
    J Clin Invest 117:153-64. 2007
    ..lacking only LDL receptors, suggesting that heparan sulfate participates in the clearance of cholesterol-rich lipoproteins as well...
  75. ncbi Fasting and nonfasting lipid levels: influence of normal food intake on lipids, lipoproteins, apolipoproteins, and cardiovascular risk prediction
    Anne Langsted
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Circulation 118:2047-56. 2008
    ..Lipid profiles are usually measured after fasting. We tested the hypotheses that these levels change only minimally in response to normal food intake and that nonfasting levels predict cardiovascular events...
  76. pmc Prediction of lipoprotein signal peptides in Gram-negative bacteria
    Agnieszka S Juncker
    Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby 2800, Denmark
    Protein Sci 12:1652-62. 2003
    ..The hidden Markov model (HMM) was able to distinguish between lipoproteins (SPaseII-cleaved proteins), SPaseI-cleaved proteins, cytoplasmic proteins, and transmembrane proteins...
  77. pmc Pal lipoprotein of Escherichia coli plays a major role in outer membrane integrity
    Eric Cascales
    Laboratoire d Ingenierie des Systemes Macromoleculaires, Institut de Biologie Structurale et de Microbiologie, CNRS, UPR 9027, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    J Bacteriol 184:754-9. 2002
    ..However, Pal was present in larger amounts compared to TolA and TolR proteins. The oligomeric state of Pal was determined and a new interaction between Pal and Lpp was demonstrated...
  78. ncbi Immunogenicity of a 2-dose priming and booster vaccination with the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine
    Sven Arne Silfverdal
    Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden
    Pediatr Infect Dis J 28:e276-82. 2009
    ....
  79. ncbi ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion
    Gregory A Graf
    McDermott Center for Human Growth and Development and Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Biol Chem 278:48275-82. 2003
    ..Finally, adenoviral expression of G2 in the presence or absence of G5 or G8 failed to promote sterol excretion into bile. These experiments indicate that G5 and G8 function as obligate heterodimers to promote sterol excretion into bile...
  80. pmc Virulence of Streptococcus pneumoniae: PsaA mutants are hypersensitive to oxidative stress
    Hsing Ju Tseng
    Centre for Metals in Biology and Department of Microbiology and Parasitology, School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    Infect Immun 70:1635-9. 2002
    ....
  81. ncbi Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells
    Akio Kawakami
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 113:691-700. 2006
    b>Lipoproteins containing apolipoprotein (apo) CIII predict coronary heart disease and associate with components of the metabolic syndrome. ApoCIII inhibits lipoprotein catabolism in plasma...
  82. ncbi Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus
    Masahito Hashimoto
    Department of Nanostructure and Advanced Materials, Kagoshima University, Kagoshima, Japan
    J Immunol 177:3162-9. 2006
    ..However, we previously demonstrated that LTA fraction prepared from bacterial cells contains lipoproteins, which activate cells via TLR2...
  83. ncbi Trends in serum lipids and lipoproteins of adults, 1960-2002
    Margaret D Carroll
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    JAMA 294:1773-81. 2005
    ....
  84. ncbi Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em
    Matthew I Hutchings
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Trends Microbiol 17:13-21. 2009
    Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins...
  85. pmc Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol
    Jelske N van der Veen
    Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands
    J Biol Chem 284:19211-9. 2009
    ..This pathway is sensitive to pharmacological activation of the LXR system. These data support the concept that the intestine substantially contributes to reverse cholesterol transport...
  86. ncbi Identification of Francisella tularensis lipoproteins that stimulate the toll-like receptor (TLR) 2/TLR1 heterodimer
    Shalini Thakran
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 283:3751-60. 2008
    ..Here we report the identification of two Francisella lipoproteins, TUL4 and FTT1103, which activate TLR2...
  87. pmc Epitope mapping of immunogenic and adhesive structures in repetitive domains of Mycoplasma bovis variable surface lipoproteins
    K Sachse
    Division 4, Federal Institute for Health Protection of Consumers and Veterinary Medicine BgVV, 07743 Jena, Germany
    Infect Immun 68:680-7. 2000
    The family of variable surface lipoproteins (Vsps) of the bovine pathogen Mycoplasma bovis includes some of the most immunogenic antigens of this microorganism...
  88. ncbi Identification of novel members reveals the structural and functional divergence of lepidopteran-specific Lipoprotein_11 family
    Yan Zhang
    State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China
    Funct Integr Genomics 12:705-15. 2012
    ..ENF-BP genes are expressed predominantly in the hemocyte. The differential spatial-temporal expression profiles revealed the functional divergence of three Lipoprotein_11 subfamilies...
  89. ncbi Why is non-high-density lipoprotein cholesterol a better marker of the risk of vascular disease than low-density lipoprotein cholesterol?
    Allan Sniderman
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Room H7 22, Royal Vic Hosp, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
    J Clin Lipidol 4:152-5. 2010
    ..Rather, non-HDL-C appears to be an indirect way of estimating apoB. We argue that we should integrate the information from non-HDL-C and apoB for better risk assessment and a better target of therapy...
  90. ncbi Lipid disorders in type 1 diabetes
    B Verges
    Service d endocrinologie, de diabétologie et des maladies métaboliques, Hopital du Bocage, Dijon, France
    Diabetes Metab 35:353-60. 2009
    Patients with type 1 diabetes (T1D) also present with lipid disorders. Quantitative abnormalities of lipoproteins are observed in T1D patients with poor glycaemic control (increased plasma triglycerides and low-density lipoprotein [LDL] ..
  91. ncbi Dissecting the complete lipoprotein biogenesis pathway in Streptomyces scabies
    David A Widdick
    School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
    Mol Microbiol 80:1395-412. 2011
    Following translocation, bacterial lipoproteins are lipidated by lipoprotein diacylglycerol transferase (Lgt) and cleaved of their signal peptides by lipoprotein signal peptidase (Lsp)...
  92. doi Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation
    John D Brunzell
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, and the Northwest Lipid Laboratory, University of Washington, Seattle, Washington, USA
    Diabetes Care 31:811-22. 2008
  93. ncbi The cholesterol content of Western diets plays a major role in the paradoxical increase in high-density lipoprotein cholesterol and upregulates the macrophage reverse cholesterol transport pathway
    Joan Carles Escola-Gil
    Institut d Investigacions Biomèdiques Sant Pau, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 31:2493-9. 2011
    ..The present study aimed to determine the effects of this Western-type diet on high-density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT) from macrophages to feces...
  94. pmc Exercise, lipids, and lipoproteins in older adults: a meta-analysis
    George A Kelley
    Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506, USA
    Prev Cardiol 8:206-14. 2005
    The authors used the meta-analytic approach to examine the effects of aerobic exercise on lipids and lipoproteins in adults 50 years of age and older...
  95. ncbi Lipid and lipoprotein profile in physiological pregnancy
    Giuseppe Lippi
    Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita di Verona, Italy
    Clin Lab 53:173-7. 2007
    ..associated with a broad series of metabolic adaptations which may also influence the metabolism of lipids and lipoproteins. Although the modification of serum lipids and lipoproteins has been exhaustively investigated during and after ..
  96. pmc Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy
    Lei Zhang
    Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Lipid Res 52:175-84. 2011
    ..Lipoprotein structure-function relationships provide important clues that help identify the role of lipoproteins in cardiovascular disease...
  97. ncbi Alkylresorcinols from whole-grain wheat and rye are transported in human plasma lipoproteins
    Anna Maria Linko-Parvinen
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, Division of Clinical Chemistry, University of Helsinki, FIN 00014 Helsinki, Finland
    J Nutr 137:1137-42. 2007
    ..Plasma alkylresorcinols are transported in lipoproteins with VLDL and HDL being the main carriers...
  98. ncbi Crystal structure of Escherichia coli BamB, a lipoprotein component of the β-barrel assembly machinery complex
    Kelly H Kim
    Department of Molecular Biology and Biochemistry, Simon Fraser University, South Science Building, 8888 University Drive, Burnaby, British Columbia, Canada
    J Mol Biol 406:667-78. 2011
    ..The BAM complex in Escherichia coli consists of five proteins: one β-barrel membrane protein, BamA, and four lipoproteins, BamB, BamC, BamD, and BamE...
  99. ncbi SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA
    J Lipid Res 49:107-14. 2008
    ..Previous findings of increased atherosclerosis in mice transplanted with SR-BI(-/-) bone marrow probably cannot be explained by a defect in macrophage cholesterol efflux...
  100. pmc Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption
    M H Lee
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina, USA
    Nat Genet 27:79-83. 2001
    ..H.L. et al., manuscript submitted). We now report that a new member of the ABC transporter family, ABCG5, is mutant in nine unrelated sitosterolemia patients...
  101. pmc Crossveinless d is a vitellogenin-like lipoprotein that binds BMPs and HSPGs, and is required for normal BMP signaling in the Drosophila wing
    Jun Chen
    Department of Zoology, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 139:2170-6. 2012
    ....

Research Grants78

  1. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..E2 and P4 implants to simulate an artificial menstrual cycle and levels of high, low, and very-low density lipoproteins (HDL, LDL, VLDL, respectively) and triglycerides in serum will be measured as indicators of cardiovascular risk...
  2. MECHANISMS IN THE REGULATION OF SP-A GENE EXPRESSION
    Carole R Mendelson; Fiscal Year: 2013
    ....
  3. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..In the future, individual patients with variation in these genes may benefit from targeted behavioral and/or pharmacological interventions designed to improve their health. ..
  4. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..We will assay markers of: (1) lipids and lipoproteins (apoA-I, apoA-II, apoB, apoC-III, apoE, lipoprotein(a), lipoprotein subclasses, oxidized phospholipids, ..
  5. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
    ..This novel signal pathway represents a new therapeutic target for the treatment of neuromuscular disease. ..
  6. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..We are proposing studies that will provide a more complete understanding of relationships between alcohol consumption, vitamin A metabolism and actions, and alcoholic organ damage. ..
  7. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ..apo) B synthesis through increased apob gene transcription which favors hepatic TG export in very low density lipoproteins (VLDL) and reduces liver TG content by 45%...
  8. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    ..Aim #2 will investigate the oxidative modification of lipoproteins and lipids by VPO. The ability of purified VPO to oxidize LDL lipoprotein and lipid will be emphasized...
  9. Prolonged Inhibition of Pathologic Neovascularization by Catalytic Antioxidants
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2013
    ....
  10. Thyroid Hormone Action
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ....
  11. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..The greatest potential for arresting this epidemic is likely to come through a clearer understanding of its molecular pathogenesis to develop rational and mechanism based therapy. ..
  12. Regulation of Hepatic SphK2 by Bile Acids: Effects on Lipid Metabolism
    HUIPING ROSE ZHOU; Fiscal Year: 2013
    ..genes encoding enzymes/proteins involved in the metabolism/synthesis of bile acids, glucose, fatty acids, and lipoproteins as well as energy metabolism by activating specific nuclear receptors, a G protein coupled receptor (GPCR, TGR5)..
  13. Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodege
    Thomas O Obisesan; Fiscal Year: 2010
    ....
  14. Characterization of new toxins (YmgD and YdfD) from E.coli, targeting cell wall
    Hisako Masuda; Fiscal Year: 2012
    ..Lol complex is responsible for translocating outer membrane lipoproteins, including Lpp, from inner the membrane to the outer membrane...
  15. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2013
    ..by adipose tissue (AT) and liver-and with increased hepatic production of triglyceride-rich lipoproteins (TGRLs) and increased levels of fatty acids (FAs, saturated FAs in particular)...
  16. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2012
    Lymph is rich in lipids, including lipoproteins, and the return of cholesterol from tissues to the vasculature and ultimately the liver depends not only on the loading of cholesterol onto high-density lipoprotein (HDL) particles within ..
  17. The Impact of Obstructive Sleep Apnea on Non-Alcoholic Fatty Liver Disease
    KATHLEEN ELIZABETH COREY; Fiscal Year: 2013
    ..in 8 first author publications including the identification of a two lipid biomarkers, oxidized low density lipoproteins (OxLDL) and non-high density lipoprotein cholesterol for NAFLD...
  18. MECHANISMS OF MILK LIPID SECRETION
    JAMES LEWIS MCMANAMAN; Fiscal Year: 2013
    ....
  19. Chemical Biology Studies of 3-Iodothyronamine and Related Thyroid Hormone Metabol
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..4) Determine the mechanism of intracellular uptake of T1AM and search for T1AM target proteins. ..
  20. Mechanisms of ethanol-induced neurodevelopmental effects
    Marina Guizzetti; Fiscal Year: 2011
    ..brain, cholesterol is mostly produced endogenously, and its homeostasis is regulated by endogenously produced lipoproteins and cholesterol transporters...
  21. The Postischemia Inflammatory Syndrome in the Aged Kidney
    KATHERINE JULIA KELLY; Fiscal Year: 2013
    ..Nearly one-half of patient beginning dialysis for CKD were e65 yo. We propose to study inflammatory and vascular injury and cell death and the effects of potential therapies in a model of CKD. ..
  22. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2010
    ..This animal model will provide academic and industrial research communities with an opportunity to better understand cardiovascular disease and its pathogenesis, and to develop and test new therapeutics and preventative strategies. ..
  23. Mechanisms of Obesity in Mice with Neuron-Specific Lipoprotein Lipase Deficiency
    Robert H Eckel; Fiscal Year: 2013
    ..is the rate limiting enzyme for the uptake of fatty acids from the hydrolysis of circulating triglyceride-rich lipoproteins for lipid storage and/or oxidation in peripheral tissues...
  24. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013
    ..myeloperoxidase (MPO);3) cell free hemoglobin (Hb);and, 4) oxidized lipids prevents oxidation of HDL and other lipoproteins in the SCD mice with asthma...
  25. Regulation of Triglyceride Metabolism by the transcription factor CREB-H
    Ann Hwee Lee; Fiscal Year: 2013
    ....
  26. Metabolic impact of fructose restriction in obese children
    Jean Marc Schwarz; Fiscal Year: 2013
    ..abstract_text> ..
  27. Adiponectin and fetal programming
    Jianhua Shao; Fiscal Year: 2013
    ..These studies will reveal new pathways of fetal programming that will lead to new therapeutic approaches to stop the vicious cycle of maternal-offspring obesity. ..
  28. Metabolic Actions of Omega-3 Fatty Acids on Inflammation
    Michael Miller; Fiscal Year: 2013
    ..ALA supplementation on 1) Metabolic (e.g., lipoproteins, inflammatory cytokines, acute phase reactants, glucose tolerance/insulin resistance) and adipose tissue ..
  29. Adipose Tissue Macrophage Phenotype and Function
    Anthony W Ferrante; Fiscal Year: 2013
    ....
  30. Regulation of factor VIII Levels and Activity by Members of LDL Receptor Family
    Dudley K Strickland; Fiscal Year: 2013
    ..endocytic receptor that plays an important role in the catabolism of several ligands including apoE-enriched lipoproteins, plasminogen activators, and serpin-enzyme complexes...
  31. Plasma Lipid Markers and Cancer Risk
    Lu Wang; Fiscal Year: 2013
    ....
  32. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2012
    ..Thus, this work will accelerate the discovery of novel therapies for this costly and deadly disease. ..
  33. Hepatic Lipase and HCV Infection
    Tianyi Wang; Fiscal Year: 2010
    ..Because it is known that HSPG mediates the initial HCV attachment and circulating HCV associates with lipoproteins, we hypothesize that elevated levels of HL and LPL may regulate the HCV infection and production in either cell-..
  34. Sphingosine 1-phosphate and cardioprotection
    JOEL SAMUEL KARLINER; Fiscal Year: 2012
    ..Secretion of S1P leads to extensive binding by albumin and plasma lipoproteins and circulation at nanomolar to micromolar concentrations...
  35. Regulation of Signaling Receptor Activity by LRP-1
    Steven L Gonias; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Low density lipoprotein receptor-related protein has emerged as an important regulator of inflammation and atherosclerosis. This proposal seeks to elucidate the responsible mechanisms. ..
  36. Lipoprotein Structure and Function by Individual Particle Electron Tomography
    Gang Ren; Fiscal Year: 2013
    ..Major risk factors for CVD are the plasma lipoprotein levels. Lipoproteins are classified according to their densities as high , low-, intermediate- and very low-density lipoproteins (..
  37. Group B. Streptococci and Toll-like Receptors
    Douglas T Golenbock; Fiscal Year: 2012
    ..First, we have identified lipoproteins as endotoxins that constitute functional equivalents to the well defined lipopolysaccharide in Gram-negative ..
  38. Over-Expression of microRNA-126 in Macrophages for Treatment of Atherosclerosis
    Suzette Laing; Fiscal Year: 2013
    ..In atherosclerosis, the earliest lesions contain macrophages that have phagocytized and accumulated modified lipoproteins. The continued monocyte recruitment and cholesterol accumulation in the vessel wall facilitates chronic disease ..
  39. Role of NPC1L1 in regulating energy metabolism, nutrient utilization & weight gai
    Philip N Howles; Fiscal Year: 2010
    ..Preliminary studies into other physiological effects of ezetimibe have revealed that postprandial intestinal lipoproteins from ezetimibe-treated mice are different in size and composition than those from control mice...
  40. Optimal Selective Thyroid Hormone Analogs for Metabolic Syndrome
    John D Baxter; Fiscal Year: 2010
    ..We will find drugs that will safely treat high cholesterol and obesity and work through one class of these proteins, thyroid hormone receptors. ..
  41. Interactions of Diesel Exhaust and Respiratory Viruses in Asthmatic Children
    Toby C Lewis; Fiscal Year: 2013
    ..2 million people in the United States, thus pointing the way towards targeted therapies and public health approaches. ..
  42. IGF-1, bone turnover and response to teriparatide in premenopausal women with IOP
    Adi Cohen; Fiscal Year: 2013
    ....
  43. Lipid Metabolism and Steatosis in Liver
    Amrita Kamat; Fiscal Year: 2013
    ..The study is expected to have an important impact by defining new molecular targets for the prevention and/or treatment of NAFLD and its complications. ..
  44. Macrophage AMPK, Inflammation, and Atherosclerosis
    Bingzhong Xue; Fiscal Year: 2013
    ..Completing these studies will greatly improve our knowledge on the role of macrophage AMPK in the protection against inflammation-associated metabolic disorders, including atherosclerosis and insulin resistance. ..
  45. Avoiding toxicity associated with MTP ablation
    M Mahmood Hussain; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): High plasma lipids and lipoproteins are risk factors for various cardiovascular and metabolic disorders...
  46. Tick Midgut Proteins Critical for Borrelia Transmission
    Sukanya Narasimhan; Fiscal Year: 2010
    ..In this proposal we will identify tick midgut proteins that interact with Borrelia during spirochete growth and migration and examine the impact of this interaction on Borrelia growth in the tick and transmission to the murine host. ..
  47. Smooth muscle cell lipid metabolism and serum amyloid A
    Barbara M Schreiber; Fiscal Year: 2010
    ..Serum amyloid A (SAA) accumulates in atherosclerotic plaques by deposition from plasma lipoproteins and/or local synthesis...
  48. Primate Fetal Adrenal Development: Impact on Physiological Processes After Birth
    Eugene D Albrecht; Fiscal Year: 2013
    ....
  49. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..Translation: Ap is an expedient marker to analyze aging effects on ISF-CSF relationships, and the compromised solute clearance by malfunctioning barrier systems. This sheds light on neurodegeneration. ..
  50. Daily Experience in Adolescence and Biomarkers of Early Risk for Adult Health
    Andrew J Fuligni; Fiscal Year: 2013
    ..blood spots will be obtained for the assessment of c-reactive-protein (CRP), cholesterol, and high density lipoproteins (HDL)...
  51. Role of Lipoproteins in Chagasic heart disease
    JYOTHI FALGUNI NAGAJYOTHI; Fiscal Year: 2013
    ..Serum lipoproteins such as LDL, very Low Density Lipoprotein (VLDL) and HDL likely play a major role in the progression of ..
  52. Novel mechanisms of niacin to improve HDL function: Role of myeloperoxidase
    Moti L Kashyap; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Physiologically functional high density lipoproteins (HDL) are protective against development of atherosclerotic cardiovascular disease (CVD)...
  53. Plasminogen activators and NMDA after brain injury
    William M Armstead; Fiscal Year: 2012
    ..Immunohistochemistry, detection of plasminogen activator and MAPK expression, and CBF determination by radiolabled microspheres will be performed. ..
  54. Quorum sensing regulation of EHEC virulence genes
    Vanessa Sperandio; Fiscal Year: 2013
    ..Specific Aim 2. To elucidate the post-transcriptional regulation of the LEE and espFu genes by the glmY sRNA. Specific Aim 3. To characterize the role of the lipoprotein QseG in attaching and effacing (AE) lesion formation. ..
  55. Shared Mechanisms of Valvular and Vascular Calcification
    JOEL DAVID MORRISETT; Fiscal Year: 2012
    ..aortic valves, porcine mitral valves, and various regions of human calcified aortic valves to bind plasma lipoproteins (Aim 3)...
  56. CELLS PROCESSING HIGH DENSITY LIPOPROTEINS
    Salman Azhar; Fiscal Year: 2013
    ..Both bile acids and steroids are synthesized from SR-BI-mediated selectively delivered cholesterol, thus underscoring the relevance of understanding the cellular mechanisms controlling the functional expression of SR-BI. ..
  57. Metabolic Syndrome and Periodontitis
    ELIZABETH A KAYE; Fiscal Year: 2013
    ..This proposed epidemiologic study is a timely and cost-effective means to better understand the relationship between periodontal disease and the metabolic syndrome. ..
  58. Eicosanoids and Endothelial Cell Dysfunction
    Gadiparthi N Rao; Fiscal Year: 2013
    ....
  59. CORONARY DISEASE MORBIDITY AND MORTALITY IN A POPULATION
    Veronique L Roger; Fiscal Year: 2012
    ..It will determine the importance of novel biomarkers to predict the risk of adverse events in clinical practice. ..
  60. RISK FACTORS FOR CVD IN WOMEN
    JOANN ELISABETH MANSON; Fiscal Year: 2012
    ..These promising biochemical and genetic markers may have implications for improving prevention strategies, enhancing treatment options, and generating additional testable hypotheses for heart disease research. ..
  61. The Magnesium and Metabolic Syndrome Trial
    Stella Lucia Volpe; Fiscal Year: 2010
    ..If effective in improving insulin resistance in the metabolic syndrome, magnesium supplementation could have a great public health impact by delaying or preventing type 2 diabetes mellitus, and also in decreasing health care costs. ..
  62. ENHANCEMENT OF CORONARY CONSTRICTION BY COMBUSTION-SOURCE AIR TOXICS
    Matthew J Campen; Fiscal Year: 2012
    ..Results from these studies will assist in the assessment and management of personal risk of health effects from air pollution exposure. ..
  63. Epidemiology of Retinopathy and other Complications in Long Term Type 1 Diabetes
    Michael Y Tsai; Fiscal Year: 2013
    ..These data will be important to patients and their physicians in developing new interventions for managing type 1 diabetes and to public health practitioners charged with delivering preventive care. ..
  64. Treatment of Acute Coronary Syndromes with Recombinant LCAT Infusion
    BRIAN ROBERT KRAUSE; Fiscal Year: 2011
    ....
  65. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2004
    DESCRIPTION: Apolipoprotein (apo) B is the major apoprotein in the triglyceride-rich lipoproteins, chylomicrons, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), as well as low-density lipoproteins (LDL) ..
  66. Antigenic variation by multiple promoter inversions in Mycoplasma penetrans
    Michael Calcutt; Fiscal Year: 2009
    ..penetrans-derived lipoproteins stimulate HIV-1 replication, raises the possibility that this Mycoplasma may be a contributory co-pathogen in ..
  67. Endoplasmic reticulum stress and foam cell formation
    Zhongmao Guo; Fiscal Year: 2010
    ..Similarly, ApoE-deficient (ApoE-/-) mice elevate plasma ApoB48-carrying lipoproteins and develop atherosclerosis in a manner that resembles the human disease...
  68. ASSEMBLY OF NASCENT PLASMA LIPOPROTEINS BY HEPATOCYTES
    Robert Hamilton; Fiscal Year: 1991
    ..abstract): The long-term goals of this research are to determine the mechanisms by which hepatocytes secrete lipoproteins and apolipoproteins...
  69. Pathogenesis of Lyme Borreliosis in the Rhesus Monkey
    MARIO PHILIPP; Fiscal Year: 2007
    ..The secondary hypothesis is that spirochetal lipoproteins can induce, in part or in toto, the inflammatory effects of B. burgdorferi...
  70. APOE3 AND APOE4 EFFECTS ON CELLULAR PATHOBIOLOGY
    ROBERT PITAS; Fiscal Year: 1999
    ..Only apoE added to the cell with beta- migrating very low density lipoproteins (beta-VLDL) or lipid emulsions had an effect, and the effect was blocked by reductive methylation of apoE or by ..
  71. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2010
    ..will be determined by the 2-dimensional gel analysis, and indicate the capabilities of the systems to mimic lipoproteins. Kinetic studies of the particle delivery systems bi-directionally across Brain Blood Barrier (BBB) will be ..
  72. Pharmacogenetics of the Statin Response
    ERNST SCHAEFER; Fiscal Year: 2006
    ..These results can be used to formulate guidelines for identifying elderly subjects for statin treatment to prevent future CHD. ..
  73. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2003
    ..Obesity increases CHD risk by adversely affecting glucose, lipoproteins, and blood pressure...
  74. APOLIPOPROTEIN E BINDING TO RECEPTORS
    David Chappell; Fiscal Year: 1991
    The interaction of lipoproteins with lipoprotein receptors is a fundamental factor influencing the levels of plasma lipoproteins and delivery of lipids to tissues...
  75. Quantitation of Tocopherol Metabolism in Humans
    ANDREW JOSEPH CLIFFORD; Fiscal Year: 2010
    ..The null hypothesis is that EHT-a-TOC eliminated through "reverse cholesterol transfer." Plasma lipoproteins play key roles in delivering RRR-a-TOC to and from EHT...
  76. CORONARY ARTERY DISEASE AND POSTPRANDIAL LIPOPROTEINS
    Henry Ginsberg; Fiscal Year: 1992
    Epidemiologic evidence for an association between risk for developing CAD and fasting levels of plasma lipids, lipoproteins and apolipoproteins is derived from international cross-sectional data, prospective within-country population ..
  77. INTESTINAL LIPOPROTEINS IN THE NEONATE
    Dennis Black; Fiscal Year: 2007
    ..the following specific hypotheses: a) the enhancement of lipid secretion is due to increased size of secreted lipoproteins, and the particles have a normal complement of other apolipoproteins; b) absorbed fatty acid type (chain length ..
  78. LIPOPROTEIN LIPASE MODULATION OF TISSUE LIPID UPTAKE
    JOSEPH OBUNIKE; Fiscal Year: 1999
    ..LPL) is the major enzyme responsible for hydrolysis of triglyceride (TG) molecules present in circulating lipoproteins. LPL is thought to interact with circulating lipoproteins while bound to cell surface glycosaminoglycans on the ..