glycolipids

Summary

Summary: Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)

Top Publications

  1. ncbi Activation of natural killer T cells by glycolipids
    Emmanuel Tupin
    La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    Methods Enzymol 417:185-201. 2006
  2. pmc Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
    Yuki Kinjo
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 12:966-74. 2011
  3. pmc MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence
    Scott E Converse
    Department of Microbiology and Immunology, G W Hooper Foundation, University of California, San Francisco 94143, USA
    Proc Natl Acad Sci U S A 100:6121-6. 2003
  4. doi Schistosoma mansoni worm glycolipids induce an inflammatory phenotype in human dendritic cells by cooperation of TLR4 and DC-SIGN
    Caroline M W van Stijn
    VU University Medical Center, Van den Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Mol Immunol 47:1544-52. 2010
  5. doi Harnessing invariant NKT cells in vaccination strategies
    Vincenzo Cerundolo
    Tumour Immunology Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DU, UK
    Nat Rev Immunol 9:28-38. 2009
  6. pmc Rhamnolipid surfactant production affects biofilm architecture in Pseudomonas aeruginosa PAO1
    Mary E Davey
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    J Bacteriol 185:1027-36. 2003
  7. pmc High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling
    Priscille Brodin
    Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Seongbuk gu, Seoul, Korea
    PLoS Pathog 6:e1001100. 2010
  8. ncbi Small-molecule pheromones that control dauer development in Caenorhabditis elegans
    Rebecca A Butcher
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, Massachusetts 02115, USA
    Nat Chem Biol 3:420-2. 2007
  9. ncbi Mapping fucosylated epitopes on glycoproteins and glycolipids of Schistosoma mansoni cercariae, adult worms and eggs
    M L M Robijn
    Department of Parasitology, Centre of Infectious Diseases, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    Parasitology 130:67-77. 2005
  10. pmc Location, synthesis and function of glycolipids and polyglycerolphosphate lipoteichoic acid in Gram-positive bacteria of the phylum Firmicutes
    Nathalie T Reichmann
    Section of Microbiology, Imperial College London, South Kensington Campus, London, UK
    FEMS Microbiol Lett 319:97-105. 2011

Detail Information

Publications276 found, 100 shown here

  1. ncbi Activation of natural killer T cells by glycolipids
    Emmanuel Tupin
    La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    Methods Enzymol 417:185-201. 2006
    ..1, a C-type lectin expressed by natural killer (NK) cells. NKT cells use their TCR to recognize glycolipids bound to or presented by CD1d...
  2. pmc Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
    Yuki Kinjo
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 12:966-74. 2011
    ..Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, ..
  3. pmc MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence
    Scott E Converse
    Department of Microbiology and Immunology, G W Hooper Foundation, University of California, San Francisco 94143, USA
    Proc Natl Acad Sci U S A 100:6121-6. 2003
    ....
  4. doi Schistosoma mansoni worm glycolipids induce an inflammatory phenotype in human dendritic cells by cooperation of TLR4 and DC-SIGN
    Caroline M W van Stijn
    VU University Medical Center, Van den Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Mol Immunol 47:1544-52. 2010
    ..We show here that Schistosoma mansoni worm glycolipids induce DC activation as indicated by upregulation of the maturation markers CD80, CD86 and MHC-II, as well as ..
  5. doi Harnessing invariant NKT cells in vaccination strategies
    Vincenzo Cerundolo
    Tumour Immunology Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DU, UK
    Nat Rev Immunol 9:28-38. 2009
    ..In addition, we describe structural and kinetic analyses that assist in the design of optimal iNKT-cell agonists that could be used in the clinical setting as vaccine adjuvants...
  6. pmc Rhamnolipid surfactant production affects biofilm architecture in Pseudomonas aeruginosa PAO1
    Mary E Davey
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    J Bacteriol 185:1027-36. 2003
    ..We propose that the maintenance of biofilm architecture represents a previously unrecognized step in the development of these microbial communities...
  7. pmc High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling
    Priscille Brodin
    Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Seongbuk gu, Seoul, Korea
    PLoS Pathog 6:e1001100. 2010
    ..the mutants in Rv1503c and Rv1506c were perturbed in the biosynthesis of acyltrehalose-containing glycolipids. Our results suggest that such glycolipids indeed play a critical role in the early intracellular fate of the ..
  8. ncbi Small-molecule pheromones that control dauer development in Caenorhabditis elegans
    Rebecca A Butcher
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, Massachusetts 02115, USA
    Nat Chem Biol 3:420-2. 2007
    ..The identification of dauer pheromone components 1 and 2 will facilitate the identification of target receptors and downstream signaling proteins...
  9. ncbi Mapping fucosylated epitopes on glycoproteins and glycolipids of Schistosoma mansoni cercariae, adult worms and eggs
    M L M Robijn
    Department of Parasitology, Centre of Infectious Diseases, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    Parasitology 130:67-77. 2005
    ..Lewis X was found both on glycolipids and glycoproteins, yet with completely different expression patterns during the life-cycle: on glycolipids, ..
  10. pmc Location, synthesis and function of glycolipids and polyglycerolphosphate lipoteichoic acid in Gram-positive bacteria of the phylum Firmicutes
    Nathalie T Reichmann
    Section of Microbiology, Imperial College London, South Kensington Campus, London, UK
    FEMS Microbiol Lett 319:97-105. 2011
    ..Furthermore, we will reintroduce the idea that LTA remains in close proximity to the bacterial membrane for its function during bacterial growth rather than as a surface-exposed structure...
  11. ncbi A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response
    Michael B Reed
    Tuberculosis Research Section, NIAID, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA
    Nature 431:84-7. 2004
    ..Furthermore, the overproduction of PGL by M. tuberculosis or the addition of purified PGL to monocyte-derived macrophages was found to inhibit the release of these pro-inflammatory mediators in a dose-dependent manner...
  12. pmc Two-enzyme systems for glycolipid and polyglycerolphosphate lipoteichoic acid synthesis in Listeria monocytogenes
    Alexander J Webb
    Department of Microbiology, Imperial College London, London, UK
    Mol Microbiol 74:299-314. 2009
    ..Inactivation of LtaS leads to severe growth and cell division defects, underscoring the pivotal role of LTA in this gram-positive pathogen...
  13. ncbi The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids
    S A Porcelli
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Annu Rev Immunol 17:297-329. 1999
    ..by CD1 has revealed the surprising finding that these are predominantly a variety of foreign lipids and glycolipids, including several found prominently in the cell walls and membranes of pathogenic mycobacteria...
  14. pmc Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids
    Ya Jen Chang
    Genomics Research Center, Academia Sinica, Taipei 115, Taiwan
    Proc Natl Acad Sci U S A 104:10299-304. 2007
    ..In vitro, glycolipids containing an aromatic ring in their acyl tail or sphingosine tail were more effective than alpha-GalCer in ..
  15. pmc Elevated globotriaosylsphingosine is a hallmark of Fabry disease
    Johannes M Aerts
    Amsterdam Lysosome Center, Departments of Medical Biochemistry, Internal Medicine, and Paediatrics, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 105:2812-7. 2008
    ..Our findings suggest that measurement of circulating globotriaosylsphingosine will be useful to monitor Fabry disease and may contribute to a better understanding of the disorder...
  16. pmc A Staphylococcus aureus ypfP mutant with strongly reduced lipoteichoic acid (LTA) content: LTA governs bacterial surface properties and autolysin activity
    Iris Fedtke
    Cellular and Molecular Microbiology Division, University of Tubingen, Department of Medical Microbiology and Hygiene, 72076 Tubingen, Germany
    Mol Microbiol 65:1078-91. 2007
    ..We propose to consider LTA and its biosynthetic enzymes as targets for new antibiofilm strategies...
  17. pmc Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements
    Else Marie Agger
    Adjuvant Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 3:e3116. 2008
    ..The development of new adjuvants capable of inducing highly complex immune responses with strong antigen-specific T-cell responses in addition to antibodies is therefore urgently needed...
  18. pmc Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity
    Ya Jen Chang
    Division of Immunology and Allergy, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 121:57-69. 2011
    ..These findings suggest what we believe to be a novel pathway that can regulate AHR, and a new therapeutic strategy (treatment with glycolipid activators of this NKT cell population) for asthma...
  19. pmc Rhamnolipids modulate swarming motility patterns of Pseudomonas aeruginosa
    Nicky C Caiazza
    Department of Microbiology and Immunology, Rm 505, Vail Building, Dartmouth Medical School, Hanover, NH 03755, USA
    J Bacteriol 187:7351-61. 2005
    ..The abilities to produce and respond to rhamnolipids in the context of group behavior are discussed...
  20. pmc Prospective study of serological conversion as a risk factor for development of leprosy among household contacts
    J T Douglas
    Department of Microbiology, University of Hawaii, Honolulu, HI 96822, USA
    Clin Diagn Lab Immunol 11:897-900. 2004
    ..Seropositive household contacts had a significantly higher risk of developing leprosy (relative hazard adjusted for age and sex [aRH], 7.2), notably multibacillary leprosy (aRH = 24), than seronegative contacts...
  21. ncbi Glyco- and sphingophosphonolipids from the medusa Phyllorhiza punctata: NMR and ESI-MS/MS fingerprints
    Lauro M de Souza
    Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Parana, CP 19046, CEP 81531 990, Curitiba, PR, Brazil
    Chem Phys Lipids 145:85-96. 2007
    ..Two different groups of glycolipids and a sphingolipid were isolated by silica-gel column chromatography and characterized using GC-MS, ESI-MS, 1D, ..
  22. doi Lipids of pathogenic Mycobacteria: contributions to virulence and host immune suppression
    L Guenin-Macé
    Institut Pasteur, Unité Postulante Pathogénomique Mycobactérienne Intégrée, Paris, France
    Transbound Emerg Dis 56:255-68. 2009
    ..Here, the chemical structure, host cell receptors and biological actions of this emerging class of mycobacterial virulence factors are reviewed...
  23. pmc Synthesis of a versatile building block for the preparation of 6-N-derivatized α-galactosyl ceramides: rapid access to biologically active glycolipids
    Peter J Jervis
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Org Chem 76:320-3. 2011
    ..Biologically active glycolipids 6 and 8 have been synthesized to illustrate the applicability of the approach.
  24. doi MmpS4 promotes glycopeptidolipids biosynthesis and export in Mycobacterium smegmatis
    Caroline Deshayes
    INSERM UMR 570, Unité de Pathogénie des Infections Systémiques, Paris Cedex 15, F 75730, France
    Mol Microbiol 78:989-1003. 2010
    ..MmpS4 in Mycobacterium smegmatis is required for the production and export of large amounts of cell surface glycolipids, but is dispensable for biosynthesis per se...
  25. pmc The phenolic glycolipid of Mycobacterium tuberculosis differentially modulates the early host cytokine response but does not in itself confer hypervirulence
    Daniel Sinsimer
    Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute Center, University of Medicine and Dentistry of New Jersey, 225 Warren St, Newark, NJ 07103, USA
    Infect Immun 76:3027-36. 2008
    ..tuberculosis, it probably acts in concert with other bacterial factors which seem to be dependent on the background of the strain...
  26. ncbi Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins
    Tetsuya Okuda
    Department of Biochemistry II, Nagoya University School of Medicine, Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biol Chem 281:10230-5. 2006
    ..The lethal kinetics were similar regardless of lipopolysaccharide elimination in VT preparation, suggesting that basal Gb3/CD77 levels are sufficient for lethal effects of VTs...
  27. pmc Novel interactions of glycosaminoglycans and bacterial glycolipids mediate binding of enterococci to human cells
    Irina G Sava
    Division of Infectious Diseases, University Medical Center Freiburg, 79106 Freiburg, Germany
    J Biol Chem 284:18194-201. 2009
    ....
  28. pmc Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid
    Kelly S Doran
    Department of Pediatrics, Division of Infectious Diseases, UCSD School of Medicine, La Jolla, California 92093, USA
    J Clin Invest 115:2499-507. 2005
    ..Our data suggest that LTA expression on the GBS surface plays a role in bacterial interaction with BBB endothelium and the pathogenesis of neonatal meningitis...
  29. pmc A molecular mechanism that stabilizes cooperative secretions in Pseudomonas aeruginosa
    Joao B Xavier
    Center for Systems Biology, Harvard University, 52 Oxford St, Cambridge, MA 02138, USA
    Mol Microbiol 79:166-79. 2011
    ..More generally, prudent regulation is a mechanism to stabilize cooperation...
  30. pmc Mycobacterium tuberculosis cell wall glycolipids directly inhibit CD4+ T-cell activation by interfering with proximal T-cell-receptor signaling
    Robert N Mahon
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University and University Hospitals, Case Medical Center, 10900 Euclid Avenue, BRB 1010B, Cleveland, OH 44106 4984, USA
    Infect Immun 77:4574-83. 2009
    ..tuberculosis. Fractionation identified that M. tuberculosis cell wall glycolipids, specifically, phosphatidylinositol mannoside and mannose-capped lipoarabinomannan, were potent inhibitors...
  31. pmc Two types of MGDG synthase genes, found widely in both 16:3 and 18:3 plants, differentially mediate galactolipid syntheses in photosynthetic and nonphotosynthetic tissues in Arabidopsis thaliana
    K Awai
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama, Kanagawa 226 8501, Japan
    Proc Natl Acad Sci U S A 98:10960-5. 2001
    ..e., in inflorescence (atMGD2) and roots (atMGD3), where they conceivably influence the eukaryotic structure prominence in MGDG. In addition, their expression of type B enzymes is enhanced under phosphate deprivation...
  32. pmc The mycobacterial glycopeptidolipids: structure, function, and their role in pathogenesis
    Jeffrey S Schorey
    Department of Biological Sciences, Eck Institute for Global Health and Infectious Diseases, University of Notre Dame, Notre Dame, IN 46556, USA
    Glycobiology 18:832-41. 2008
    Glycopeptidolipids (GPLs) are a class of glycolipids produced by several nontuberculosis-causing members of the Mycobacterium genus including pathogenic and nonpathogenic species...
  33. pmc Saccharomyces cerevisiae-based molecular tool kit for manipulation of genes from gram-negative bacteria
    Robert M Q Shanks
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Appl Environ Microbiol 72:5027-36. 2006
    ..These tools can be used for genetic studies of pseudomonads and many other gram-negative bacteria...
  34. ncbi Activation of invariant natural killer T cells by synthetic glycolipid ligands suppresses autoantibody-induced arthritis
    Shinjiro Kaieda
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Arthritis Rheum 56:1836-45. 2007
    ..This study was designed to evaluate the protective effects of SGL-S23 in an effector phase of arthritis...
  35. ncbi Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes
    N Burdin
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 161:3271-81. 1998
    Mouse CD1 (mCD1) glycoproteins are known to present peptides, while human CD1 molecules present glycolipids. In mice, mCD1-autoreactive NK T cells play critical roles in various immune responses, through the secretion of high amounts of ..
  36. doi Glycolipids are involved in biofilm accumulation and prolonged bacteraemia in Enterococcus faecalis
    Christian Theilacker
    Division of Infectious Diseases, Department of Medicine, University Medical Center Freiburg, Germany
    Mol Microbiol 71:1055-69. 2009
    ..In several Gram-positive bacteria, membrane glycolipids have been implicated in biofilm formation...
  37. pmc Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa
    U A Ochsner
    Institute for Biotechnology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich
    J Bacteriol 176:2044-54. 1994
    ..Additionally, such PG201::'rhlR' mutant strains lacked elastase activity, indicating that the RhlR protein is a pleiotropic regulator...
  38. pmc Rhamnolipids: diversity of structures, microbial origins and roles
    Ahmad Mohammad Abdel-Mawgoud
    INRS Institut Armand Frappier, 531 Boulevard des Prairies, Laval, QC, H7V 1B7, Canada
    Appl Microbiol Biotechnol 86:1323-36. 2010
    ....
  39. ncbi DC-SIGN mediates binding of dendritic cells to authentic pseudo-LewisY glycolipids of Schistosoma mansoni cercariae, the first parasite-specific ligand of DC-SIGN
    Sandra Meyer
    Institute of Biochemistry, Medical Faculty, Justus Liebig University Giessen, Germany
    J Biol Chem 280:37349-59. 2005
    ..Here we report that the CLR DC-SIGN mediates adhesion of DCs to authentic glycolipids derived from Schistosoma mansoni cercariae and their excretory/secretory products...
  40. pmc Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia
    Marie Laure Michel
    Unité Mixte de Recherche 8147, Centre National de la Recherche Scientifique, Faculté de Médecine René Descartes, Paris V, Hopital Necker, Paris, Cedex 15, France
    J Exp Med 204:995-1001. 2007
    ..upon synthetic (alpha-galactosylceramide [alpha-GalCer] or PBS-57), as well as natural (lipopolysaccharides or glycolipids derived from Sphingomonas wittichii and Borrelia burgdorferi), ligand stimulation. NK1...
  41. doi Globotriaosylsphingosine actions on human glomerular podocytes: implications for Fabry nephropathy
    Maria D Sanchez-Niño
    Nefrologia, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid and Instituto Reina Sofia de Investigaciones Nefrológicas IRSIN, Madrid, Spain
    Nephrol Dial Transplant 26:1797-802. 2011
    ....
  42. doi Glycosidase-induced fusion of isoprenoid gentiobiosyl lipid membranes at acidic pH
    G Dennis Sprott
    Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Ottawa, ON K1A OR6, Canada
    Glycobiology 19:267-76. 2009
    ..Radiotracer and (1)H NMR studies revealed that glycolipids in fused archaeosomes were not degraded significantly by glucosidase treatment during fusion...
  43. doi The fidelity, occasional promiscuity, and versatility of T cell receptor recognition
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Immunity 28:304-14. 2008
    ..Collectively, these studies have revealed the versatility of the TCR in recognizing the distinct yet evolutionarily related proteinaceous and lipid-presenting molecules of the immune system...
  44. doi A subset of human pancreatic beta cells express functional CD14 receptors: a signaling pathway for beta cell-related glycolipids, sulfatide and β-galactosylceramide
    Thomas Osterbye
    Bartholin Instituttet, Rigshospitalet, Biocenter Copenhagen, Copenhagen N, Denmark
    Diabetes Metab Res Rev 26:656-67. 2010
    ..Multiple factors may contribute to the development of T1DM. Among these, the metabolic state of beta-cells and pro-inflammatory cytokines, produced by infiltrating immune cells, have been implicated in the precipitation of T1DM...
  45. pmc Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a beta-linked self-glycolipid
    Philomena Arrenberg
    Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 107:10984-9. 2010
    TCR-mediated recognition of beta-linked self-glycolipids bound to CD1d is poorly understood...
  46. doi Fatty acyl structures of mycobacterium tuberculosis sulfoglycolipid govern T cell response
    Julie Guiard
    Département Mécanismes Moléculaires des Infections Mycobactériennes, Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
    J Immunol 182:7030-7. 2009
    ..These studies have major implications for the design of sulfoglycolipid analogs with potential use as tuberculosis subunit vaccines...
  47. pmc Mutational analysis of cell wall biosynthesis in Mycobacterium avium
    Jean Pierre Laurent
    Seattle Biomedical Research Institute, Seattle, Washington 98109, USA
    J Bacteriol 185:5003-6. 2003
    ..Nineteen such mutants were isolated and mapped, including 10 with insertions in a functional island of cell wall biosynthetic genes that spans approximately 40 kb of the M. avium genome...
  48. pmc Comparative metabolomics reveals biogenesis of ascarosides, a modular library of small-molecule signals in C. elegans
    Stephan H von Reuss
    Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    J Am Chem Soc 134:1817-24. 2012
    ..Our screen further demonstrates that ascaroside biosynthesis is directly affected by nutritional status and that excretion of the final products is highly selective...
  49. ncbi Anionic lipids are required for chloroplast structure and function in Arabidopsis
    Bin Yu
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 1319, USA
    Plant J 36:762-70. 2003
    Photosynthetic membranes of plants primarily contain non-phosphorous glycolipids. The exception is phosphatidylglycerol (PG), which is an acidic/anionic phospholipid...
  50. doi The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production
    Malou Henriksen-Lacey
    School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK
    J Control Release 154:131-7. 2011
    ....
  51. doi Immune responses induced by spirochetal outer membrane lipoproteins and glycolipids
    Nicolas W J Schröder
    Department for Dermatology and Allergology, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Immunobiology 213:329-40. 2008
    ..However, there is increasing evidence that next to lipoproteins, glycolipids may also play an important role in responses of the immune system towards spirochetes...
  52. pmc Methylation of GPLs in Mycobacterium smegmatis and Mycobacterium avium
    Dharshini Jeevarajah
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Bacteriol 186:6792-9. 2004
    ..The GPLs are glycolipids that contain modified sugars including acetylated 6-deoxy-talose and methylated rhamnose...
  53. pmc How cholesterol constrains glycolipid conformation for optimal recognition of Alzheimer's beta amyloid peptide (Abeta1-40)
    Nouara Yahi
    Université Paul Cézanne Aix Marseille 3, université de la Méditerranée Aix Marseille 2, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, CNRS UMR 6231, INRA USC 2027, Interactions Moléculaires et Systèmes Membranaires, Faculté des Sciences Saint Jérôme, Marseille, France
    PLoS ONE 5:e9079. 2010
    ..These data shed some light on the complex molecular interplay between cell surface GSLs, cholesterol and Abeta peptides, and on the influence of this molecular ballet on Abeta-membrane interactions...
  54. pmc Increase in rhamnolipid synthesis under iron-limiting conditions influences surface motility and biofilm formation in Pseudomonas aeruginosa
    Rivka Glick
    The Bacterial Biofilm Research Laboratory, The Institute for Nanotechnology and Advanced Materials, The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Bacteriol 192:2973-80. 2010
    ..These results highlight the importance of biosurfactant production in determining the mature structure of P. aeruginosa biofilms under iron-limiting conditions...
  55. ncbi Structure and function of glycoglycerolipids in plants and bacteria
    Georg Hölzl
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Prog Lipid Res 46:225-43. 2007
    ....
  56. pmc A glycosyltransferase involved in biosynthesis of triglycosylated glycopeptidolipids in Mycobacterium smegmatis: impact on surface properties
    Caroline Deshayes
    INSERM UMR570, Faculte de Medecine Necker Enfants Malades, 156 rue de Vaugirard, Paris Cedex 15, F 75730, France
    J Bacteriol 187:7283-91. 2005
    ..Glycopeptidolipids (GPLs) are species- or type species-specific glycolipids that are present at the surface of a number of mycobacteria and that are characterized by a high variability in ..
  57. ncbi Testis-specific sulfoglycolipid, seminolipid, is essential for germ cell function in spermatogenesis
    Yanlong Zhang
    Department of Molecular Genetics, Kochi University Medical School, Kochi 783 8505, Japan
    Glycobiology 15:649-54. 2005
    ....
  58. ncbi Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia
    Roger G Linington
    Department of Chemistry, University of British Columbia, Vancouver, B C V6T 1Z1, Canada
    J Nat Prod 69:173-7. 2006
    ..fractionation of the crude extract led to the isolation of caminosides A (1) to D (4), a family of antimicrobial glycolipids. The structures of the three new caminosides B (2) to D (4) have been elucidated by spectroscopic analysis.
  59. doi Stem cell glycolipids
    Makoto Yanagisawa
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street CA4040, Augusta, GA 30912, USA
    Neurochem Res 36:1623-35. 2011
    b>Glycolipids are compounds containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety...
  60. ncbi The impact of the absence of glycopeptidolipids on the ultrastructure, cell surface and cell wall properties, and phagocytosis of Mycobacterium smegmatis
    Gilles Etienne
    Institut de Pharmacologie et de Biologie Structurale, Unité Mixte de Recherche du Centre de National de Recherche Scientifique et de l Université Paul Sabatier UMR 5089, 205 route de Narbonne, 31077 Toulouse Cedex 04, France
    Microbiology 148:3089-100. 2002
    ..smegmatis. Altogether, these data showed that, in addition to being distinctive markers of numerous mycobacterial species, GPLs play a role in the bacterial phenotype, surface properties and cell wall permeability...
  61. ncbi Acylated cholesteryl galactoside as a novel immunogenic motif in Borrelia burgdorferi sensu stricto
    Nicolas W J Schröder
    Institut für Mikrobiologie und Hygiene, Universitatsklinikum Charite, Medizinische Fakultat der Humboldt Universitat zu Berlin, Dorotheenstrasse 96, D 10117 Berlin, Germany
    J Biol Chem 278:33645-53. 2003
    ..Here we report on a novel class of immunogenic glycolipids purified from B. burgdorferi sensu stricto B31...
  62. ncbi Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli
    Liana Tsenova
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute, Newark, New Jersey 07103, USA
    J Infect Dis 192:98-106. 2005
    ....
  63. doi Rhamnolipid biosurfactants decrease the toxicity of chlorinated phenols to Pseudomonas putida DOT-T1E
    L Chrzanowski
    Department of Organic Chemistry, Institute of Chemical Technology and Engineering, Poznan University of Technology, Poznan, Poland
    Lett Appl Microbiol 48:756-62. 2009
    ..To investigate the effect of a mixture of rhamnolipid R1 and R2 biosurfactants produced by a Pseudomonas aeruginosa strain on the toxicity of phenol and chlorophenols to Pseudomonas putida DOT-T1E...
  64. doi Effect of monorhamnolipid on the degradation of n-hexadecane by Candida tropicalis and the association with cell surface properties
    Guangming Zeng
    College of Environmental Science and Engineering, Hunan University, Changsha 410082, People s Republic of China
    Appl Microbiol Biotechnol 90:1155-61. 2011
    ..The changes of cell surface properties may be a reason for the enhanced biodegradation of hexadecane by the yeast. The results indicate the potential application of monoRL in the bioremediation of hydrocarbons...
  65. pmc Sulfolipids and glycolipid sulfotransferase activities in human renal cell carcinoma cells
    T Kobayashi
    Biochemistry Laboratory, Hokkaido University School of Medicine, Sapporo, Japan
    Br J Cancer 67:76-80. 1993
    ..1989. Cancer Res., 49, 335-339) is due to the elevation of the sulfotransferase activities of renal carcinoma cells themselves...
  66. pmc Fine tuning by human CD1e of lipid-specific immune responses
    Federica Facciotti
    Experimental Immunology, Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland
    Proc Natl Acad Sci U S A 108:14228-33. 2011
    ..It binds lipids in lysosomes and facilitates processing of complex glycolipids, thus promoting editing of lipid antigens...
  67. pmc A blend of small molecules regulates both mating and development in Caenorhabditis elegans
    Jagan Srinivasan
    Howard Hughes Medical Institute and Biology Division, California Institute of Technology, 1200 E California Boulevard, Pasadena, California 91125, USA
    Nature 454:1115-8. 2008
    ..The ascaroside signalling system thus connects reproductive and developmental pathways and represents a unique example of structure- and concentration-dependent differential activity of signalling molecules...
  68. doi Insecticidal activity of rhamnolipid isolated from pseudomonas sp. EP-3 against green peach aphid (Myzus persicae)
    Seul Ki Kim
    Department of Agricultural Chemistry and Biology, Institute of Agricultural Science and Technology
    J Agric Food Chem 59:934-8. 2011
    ..This is the first report of rhamnolipid as an insecticidal metabolite against M. persicae. Rhamnolipid shows potential for use as a pesticide to control agricultural pests...
  69. pmc Deciphering sulfoglycolipids of Mycobacterium tuberculosis
    Emilie Layre
    CNRS IPBS Institut de Pharmacologie et de Biologie Structurale 205 route de Narbonne, F 31077, Toulouse, France
    J Lipid Res 52:1098-110. 2011
    ..Our results further confirm the requirement of MmpL8 for the complete assembly of the tetra-acylated forms of SGL and also provide, by the discovery of new intermediates, insights in terms of the possible SGL biosynthetic pathways...
  70. doi Reduction of elevated plasma globotriaosylsphingosine in patients with classic Fabry disease following enzyme replacement therapy
    Marielle J van Breemen
    Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands
    Biochim Biophys Acta 1812:70-6. 2011
    ..Our investigation revealed that ERT of Fabry patients reduces plasma lysoGb3, regardless of the recombinant enzyme used. This finding shows that ERT can correct a characteristic biochemical abnormality in Fabry patients...
  71. pmc Archaeosome vaccine adjuvants induce strong humoral, cell-mediated, and memory responses: comparison to conventional liposomes and alum
    L Krishnan
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada K1A 0R6
    Infect Immun 68:54-63. 2000
    ..Thus, archaeosomes may be potent vaccine carriers capable of facilitating strong primary and memory humoral, and cell-mediated immune responses to the entrapped antigen...
  72. ncbi Lipopentapeptide induces a strong host humoral response and distinguishes Mycobacterium avium subsp. paratuberculosis from M. avium subsp. avium
    Franck Biet
    UR1282, Infectiologie Animale, Santé Publique, INRA Centre de Tours, F 37380 Nouzilly, France
    Vaccine 26:257-68. 2008
    ..avium subsp. paratuberculosis (Map), the etiologic agent of Johne's disease in cattle, and several conflicting data have been produced...
  73. pmc The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells
    Shinji Oki
    Department of Immunology, National Institute of Neuroscience, National Center for Neuroscience and Psychiatry, Tokyo, Japan
    J Clin Invest 113:1631-40. 2004
    ..and that the length of the sphingosine chain determines the duration of NKT cell stimulation by CD1d-associated glycolipids. Furthermore, IFN-gamma production by NKT cells requires longer T cell receptor stimulation than is required ..
  74. ncbi Production of rhamnolipids by Pseudomonas aeruginosa
    Gloria Soberón-Chávez
    Departamento de Bioprocesos y Biocatálisis, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Appl Microbiol Biotechnol 68:718-25. 2005
    ..We also discuss the factors controlling the production of rhamnolipids and the proposed roles this biosurfactant plays in P. aeruginosa lifestyle...
  75. pmc A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells
    Kwok S Wun
    The Protein Crystallography Unit, ARC Centre of Excellence in Structural and Functional Microbial Genomics, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    Immunity 34:327-39. 2011
    ..Accordingly, we have provided a molecular basis for understanding how modifications in AGLs can result in striking alterations in the cellular response of NKT cells...
  76. pmc Timing and localization of rhamnolipid synthesis gene expression in Pseudomonas aeruginosa biofilms
    Yannick Lequette
    Department of Microbiology, 540 EMRB, Roy and Lucille Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Bacteriol 187:37-44. 2005
    ..The differential expression of rhlAB may play a role in the development of normal biofilm architecture...
  77. doi Quorum sensing-dependent virulence during Pseudomonas aeruginosa colonisation and pneumonia in mechanically ventilated patients
    Thilo Köhler
    Service of Infectious Diseases, University Hospital Geneva, 4 rue Gabrielle Perret Gentil, Geneva 14, Switzerland
    Thorax 65:703-10. 2010
    ..The role of quorum sensing (QS), regulating virulence in this pathogen, during colonisation and development of VAP is unknown...
  78. pmc RhlA converts beta-hydroxyacyl-acyl carrier protein intermediates in fatty acid synthesis to the beta-hydroxydecanoyl-beta-hydroxydecanoate component of rhamnolipids in Pseudomonas aeruginosa
    Kun Zhu
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    J Bacteriol 190:3147-54. 2008
    ..We conclude that RhlA is necessary and sufficient to form the acyl moiety of RL and that the flux of carbon through FASII accelerates to support RL production and maintain a supply of acyl chains for phospholipid synthesis...
  79. pmc Pseudomonas aeruginosa virulence analyzed in a Dictyostelium discoideum host system
    Pierre Cosson
    Département de Morphologie, Universite de Geneve, Centre Medical Universitaire, CH 1211 Geneva 4, Switzerland
    J Bacteriol 184:3027-33. 2002
    ..aeruginosa should show reduced virulence. This result was confirmed in a rat model of acute pneumonia. Thus, D. discoideum could be used as a simple nonmammalian host system to assess pathogenicity of P. aeruginosa...
  80. pmc Axo-glial interactions regulate the localization of axonal paranodal proteins
    J L Dupree
    Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Cell Biol 147:1145-52. 1999
    ....
  81. ncbi Self-produced extracellular stimuli modulate the Pseudomonas aeruginosa swarming motility behaviour
    Julien Tremblay
    INRS Institut Armand Frappier, Laval Quebec, H7V 1B7, Canada
    Environ Microbiol 9:2622-30. 2007
    ..We propose a model explaining how HAAs and di-RLs together modulate the behaviour of swarming migrating cells by acting as self-produced negative and positive chemotactic-like stimuli...
  82. ncbi Synthetic glycolipid OCH prevents insulitis and diabetes in NOD mice
    Miho Mizuno
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Autoimmun 23:293-300. 2004
    ....
  83. ncbi Mycobacteria use their surface-exposed glycolipids to infect human macrophages through a receptor-dependent process
    Christelle Villeneuve
    Département Mécanismes Moléculaires des Infections Mycobactériennes, Institut de Pharmacologie et Biologie Structurale, Unité Mixte de Recherche 5089 Centre National de la Recherche Scientifique, Universite Paul Sabatier, 31077 Toulouse, France
    J Lipid Res 46:475-83. 2005
    ..GPL III, but not PIM2, also directed particle entry through the mannose receptor. Therefore, surface-exposed mycobacterial PIM and polar GPL participate in the receptor-dependent internalization of mycobacteria in human macrophages...
  84. ncbi Trypanosomatid and fungal glycolipids and sphingolipids as infectivity factors and potential targets for development of new therapeutic strategies
    Erika Suzuki
    Division of Glycoconjugate Immunochemistry, Department of Biochemistry, Ed J L Prado, Rua Botucatu, 862, 04023 900, Sao Paulo, SP, Brazil
    Biochim Biophys Acta 1780:362-9. 2008
    ..Other pathogens, such as fungi, also present unique glycolipids which may have an important role for the fungal development and/or disease establishment...
  85. ncbi Preferential T(h)2 polarization by OCH is supported by incompetent NKT cell induction of CD40L and following production of inflammatory cytokines by bystander cells in vivo
    Shinji Oki
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Int Immunol 17:1619-29. 2005
    ..In addition, highlighted in this study is the characteristic property of OCH that can induce the differential production of IFN-gamma or IL-4 according to the availability of IL-12...
  86. pmc Lipid and glycolipid antigens of CD1d-restricted natural killer T cells
    Manjunatha M Venkataswamy
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Semin Immunol 22:68-78. 2010
    ..antigens provide an increasingly detailed picture of how the specific structural features of these lipids and glycolipids influence their ability to be presented to NKT cells and stimulate their diverse immunologic functions...
  87. ncbi Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa
    Peter Ø Jensen
    Department of Clinical Microbiology, Rigshospitalet, DK 2100 Copenhagen Ø, Denmark
    Microbiology 153:1329-38. 2007
    ..aeruginosa by disabling the PMNs, which are a major first line of defence of the host. Furthermore, the study emphasizes the inhibition of QS as a target for the treatment of infections with P. aeruginosa...
  88. pmc Mycobacterium leprae infection in monocyte-derived dendritic cells and its influence on antigen-presenting function
    Ken Hashimoto
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
    Infect Immun 70:5167-76. 2002
    ..M. leprae is a unique pathogen which remains resistant to DC-mediated T-cell immunity, at least in the early stages of infection...
  89. ncbi Effects of additives on the structure of rhamnolipid (biosurfactant): a small-angle neutron scattering (SANS) study
    Behnaz Dahrazma
    Department of Environmental Geology Faculty of Earth Science, Shahrood University of Technology, Shahrood 316 3619995161, Iran
    J Colloid Interface Sci 319:590-3. 2008
    ..The size of the aggregates in both acidic and basic condition is fine enough to ease the flow of the rhamnolipid solution through the porous media with the pore sizes as small as 200 nm...
  90. ncbi Glycolipids from the formosan soft coral Lobophytum crassum
    Chih Hua Chao
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan ROC
    Chem Pharm Bull (Tokyo) 55:1720-3. 2007
    Three glycolipids (1--3), possessing a sugar moiety at C-2 of glycerol ether, have been isolated from the Formosan soft coral Lobophytum crassum...
  91. ncbi Neutral glycolipids of the filamentous fungus Neurospora crassa: altered expression in plant defensin-resistant mutants
    Chaeho Park
    Complex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602 7229, USA
    J Lipid Res 46:759-68. 2005
    ..The potential implications of these findings with respect to defensin resistance in the N. crassa mutants are discussed...
  92. pmc Glycolipids as immunostimulating agents
    Douglass Wu
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Bioorg Med Chem 16:1073-83. 2008
    ..A combination of structure-activity relationship (SAR), crystallographic studies, and discovery of new 'natural' antigens has led to greater understanding of the structural requirements for optimal natural killer T-cell activation...
  93. pmc A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components
    Rebecca A Butcher
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:14288-92. 2008
    ....
  94. ncbi Murine glycosyltransferases responsible for the expression of globo-series glycolipids: cDNA structures, mRNA expression, and distribution of their products
    Yuko Fujii
    Department of Clinical Immunology, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Glycobiology 15:1257-67. 2005
    ..In this study, murine cDNAs of two glycosyltransferases responsible for the synthesis of globo-series glycolipids and mRNA expression of those genes were analyzed. Distribution of their products was also analyzed...
  95. pmc One-pot syntheses of immunostimulatory glycolipids
    Matthew Schombs
    Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    J Org Chem 75:4891-8. 2010
    b>Glycolipids containing alpha-linked galactosyl and glucosyl moieties have been shown to possess unique immunostimulatory activity creating a need for access to diverse and anomerically pure sources of these compounds for immunological ..
  96. ncbi Characteristic expression of Lewis-antigenic glycolipids in human ovarian carcinoma-derived cells with anticancer drug-resistance
    Masao Iwamori
    Department of Biochemistry, Faculty of Science and Technology, Kinki University, 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
    J Biochem 141:309-17. 2007
    ..In addition to the transporters expression, the amounts of glycolipids, particularly their longer carbohydrate structures, in the resistant cells increased to 3-4-fold of those in ..
  97. ncbi Inhibitory effect on replicative DNA polymerases, human cancer cell proliferation, and in vivo anti-tumor activity by glycolipids from spinach
    Naoki Maeda
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, 518 Arise, Ikawadanicho, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Curr Med Chem 14:955-67. 2007
    We succeeded in purifying a major glycolipids fraction (i.e...
  98. doi Membrane glycolipids in stem cells
    Robert K Yu
    Institute of Molecular Medicine and Genetics and Institute of Neuroscience, Medical College of Georgia, Augusta, GA 30912, USA
    FEBS Lett 584:1694-9. 2010
    ..Recently, studies regarding the biological functions of glycolipids and cell surface microdomains (caveolae, lipid rafts, or glycolipid-enriched microdomains) in stem cells are ..
  99. pmc Critical role of amino acid position 343 of surfactant protein-D in the selective binding of glycolipids from Mycobacterium tuberculosis
    Tracy K Carlson
    Division of Infectious Diseases, Department of Internal Medicine, Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    Glycobiology 19:1473-84. 2009
    ..We conclude that the 343 position is critical in defining the binding pattern of SP-D proteins to M.tb and its mannosylated cell envelope components...
  100. pmc Multiple roles of biosurfactants in structural biofilm development by Pseudomonas aeruginosa
    Sünje Johanna Pamp
    Centre for BioScience Technology, BioCentrum DTU, Building 301, The Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Bacteriol 189:2531-9. 2007
    ..aeruginosa biofilms demonstrated that the wild-type and rhlA and pilA mutant strains formed distinct subpopulations on top of each other dependent on their ability to migrate and produce biosurfactants...
  101. doi MALDI-TOF mass spectrometry of naturally occurring mixtures of monorhamnolipids and dirhamnolipids
    Neil P J Price
    Bioproducts and Biocatalysis, USDA ARS NCAUR, 1815 North University Street, Peoria, IL 61604, USA
    Carbohydr Res 344:204-9. 2009
    ..MALDI-TOFMS analysis allows the rapid screening of variously acylated rhamnolipids, and has potential for selective identification of new surfactants from microbial strains...

Research Grants78

  1. NKT Cells Immunotherapy: Targeting Dendritic Cells with Glycolipid Liposomes
    Peng Wang; Fiscal Year: 2007
    ..In contrast, a specialized subpopulation of T cells called NKT cells recognize glycolipids antigens presented by the MHC class l-like molecule; CD1d...
  2. The Role of Glycolipids and CD1 in the Immunology of Leishmania Infection
    Laurence U Buxbaum; Fiscal Year: 2010
    ..NKT cells are activated by an unusual protein called CD1, which is involved in immune responses provoked by glycolipids (like GIPLs). The way in which CD1 and NKT cells work in infection is not well understood...
  3. Biogenesis of lipoarabinomannan in mycobacteria
    Mary Jackson; Fiscal Year: 2010
    ..PIM) and their multiglycosylated counterparts, lipomannan (LM) and lipoarabinomannan (LAM) are complex glycolipids and lipoglycans found in the envelopes of all mycobacterial species...
  4. LIPID A MODIFICATION SYSTEMS IN GRAM-NEGATIVE BACTERIA
    CHRISTIAN RAETZ; Fiscal Year: 2007
    Lipopolysaccharides (LPSs) are remarkable glycolipids that comprise the outer surfaces of Gram-negative bacteria, including the symbiotic organism, Rhizobium leguminosamm...
  5. BIOSYNTHESIS AND REGULATION OF SUBSTITUTED SIALIC ACIDS
    Ajit Varki; Fiscal Year: 1990
    Sialic acids, which are the outermost sugars on the glycoproteins and glycolipids of mammalian cells, can be substituted at the 4,7,8, and 9 positions with O-acetyl esters (or other less common substitutions) in a tissue-specific fashion...
  6. Role of Nuclear Gangliosides in Neuronal Function
    Robert W Ledeen; Fiscal Year: 2010
    ..plasma membrane, but a number of intracellular mechanisms are now known to be mediated and modulated by these glycolipids. Our work has shown GM1 in particular to have a critical role regulating Ca2+ homeostasis in the nucleus and ..
  7. Structure and function of family 1 glycosyltransferases
    R Garavito; Fiscal Year: 2006
    ..units onto the target compounds to create a diverse set of macromolecules in plants, animals, and bacteria: glycolipids, lipopolysaccharides, the glycan structures in plants, glycoproteins, and glycosylated natural products of ..
  8. Xenograft-like rejection of tumors in a-gal glycolipids
    URI GALILI GALILI; Fiscal Year: 2010
    ..We will study this treatment in a unique mouse model that simulates the pertinent human immunological parameters. Success in the studies in the mouse model will enable us to apply this treatment to cancer patients. ..
  9. IMMUNOCHEMISTRY OF GONOCOCCAL LIPOPOLYSACCHARIDE
    JOHN GRIFFISS; Fiscal Year: 2003
    ..LOS are outer membrane glycolipids that have a glycose moiety that consists of proximal Basal Region and three short distal chains, termed alpha ..
  10. SORTING OF A LIPID-PROTEIN COMPLEX IN EPITHELIAL CELLS
    Deborah Brown; Fiscal Year: 1993
    ..Membrane complexes that contain both glycolipids and GPI-anchored proteins have been isolated, using their surprising insolubility in non-ionic detergents...
  11. CD1 AND BCR/Fc RECEPTOR TARGETED LIGAND
    Grant Yeaman; Fiscal Year: 2001
    ..Typically, CD1 molecules present lipids or glycolipids to T cells. CD1 ligands are associated with T cells specific for M. tuberculosis...
  12. SHORT- AND LONG-RANGE FORCES BETWEEN MEMBRANCE SURFACES
    THOMAS MC INTOSH; Fiscal Year: 1993
    ..In particular, these pressures will be measured for bilayers containing various glycolipids or containing lipids with covalently attached polyethylene glycol (PEG)...
  13. GLYCOSPHINGOLIPID METABOLISM AND MENTAL RETARDATION
    Glyn Dawson; Fiscal Year: 2000
    The broad, long-term objectives are to understand the role of glycolipids (glycoshingolipids (GSL) and inositolphosphoglycerides) in normal nervous function and the pathogenic processes involving them which lead to mental retardation...
  14. Glycolipid Trafficking of Cholera Toxin by Lipid Rafts
    David Saslowsky; Fiscal Year: 2007
    The goal of this application is to understand how epithelial cells of the intestinal mucosa sort membrane glycolipids into the retrograde trafficking pathway from the plasma membrane (PM) to the endoplasmic reticulum (ER), a route ..
  15. GLYCOLIPIDS AND HEMOLYTIC UREMIC SYNDROME
    David Haslam; Fiscal Year: 2002
    ..In almost all cases, verotoxins (shiga-like toxins) released by enterohemorrhagic E. coli bind to glycolipids on the endothelial cells, are then routed to the endoplasmic reticulum, and thereby inactivate the 28S ..
  16. An Untested Approach: Biomarkers for Colon Cancer
    Khushi Matta; Fiscal Year: 2007
    ..is known that cancer is associated with alterations in the glycosylation patterns of glycoconjugates including glycolipids and glycoproteins...
  17. Role of ER-Localized Chaperones in Toxin Pathogenesis
    David Haslam; Fiscal Year: 2006
    ..After binding to cell surface glycolipids, the toxin is internalized and trafficked in retrograde fashion to the Golgi and endoplasmic reticulum (ER)...
  18. Naturally Occurring IgM Anti-Leucocyte Autoantibodies Protect Against Renal IRI
    MARK DOUGLAS OKUSA; Fiscal Year: 2010
    ..Based on these findings we questioned whether IgM- ALA downregulate inflammation that accompanies renal IRI. Glycolipids released after ischemic injury are processed and presented by resident dendritic cells (DC), in presence of ..