glycolipids

Summary

Summary: Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)

Top Publications

  1. ncbi Activation of natural killer T cells by glycolipids
    Emmanuel Tupin
    La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    Methods Enzymol 417:185-201. 2006
  2. pmc Location, synthesis and function of glycolipids and polyglycerolphosphate lipoteichoic acid in Gram-positive bacteria of the phylum Firmicutes
    Nathalie T Reichmann
    Section of Microbiology, Imperial College London, South Kensington Campus, London, UK
    FEMS Microbiol Lett 319:97-105. 2011
  3. pmc Elevated globotriaosylsphingosine is a hallmark of Fabry disease
    Johannes M Aerts
    Amsterdam Lysosome Center, Departments of Medical Biochemistry, Internal Medicine, and Paediatrics, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 105:2812-7. 2008
  4. pmc Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
    Yuki Kinjo
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 12:966-74. 2011
  5. ncbi Quorum sensing and swarming migration in bacteria
    Ruth Daniels
    Centre of Microbial and Plant Genetics, K U Leuven, Kasteelpark Arenberg 20, 3001 Heverlee, Belgium
    FEMS Microbiol Rev 28:261-89. 2004
  6. pmc Rhamnolipids: diversity of structures, microbial origins and roles
    Ahmad Mohammad Abdel-Mawgoud
    INRS Institut Armand Frappier, 531 Boulevard des Prairies, Laval, QC, H7V 1B7, Canada
    Appl Microbiol Biotechnol 86:1323-36. 2010
  7. pmc Two-enzyme systems for glycolipid and polyglycerolphosphate lipoteichoic acid synthesis in Listeria monocytogenes
    Alexander J Webb
    Department of Microbiology, Imperial College London, London, UK
    Mol Microbiol 74:299-314. 2009
  8. ncbi Schistosoma mansoni worm glycolipids induce an inflammatory phenotype in human dendritic cells by cooperation of TLR4 and DC-SIGN
    Caroline M W van Stijn
    VU University Medical Center, Van den Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Mol Immunol 47:1544-52. 2010
  9. ncbi Small-molecule pheromones that control dauer development in Caenorhabditis elegans
    Rebecca A Butcher
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, Massachusetts 02115, USA
    Nat Chem Biol 3:420-2. 2007
  10. pmc High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling
    Priscille Brodin
    Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Seongbuk gu, Seoul, Korea
    PLoS Pathog 6:e1001100. 2010

Detail Information

Publications309 found, 100 shown here

  1. ncbi Activation of natural killer T cells by glycolipids
    Emmanuel Tupin
    La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    Methods Enzymol 417:185-201. 2006
    ..1, a C-type lectin expressed by natural killer (NK) cells. NKT cells use their TCR to recognize glycolipids bound to or presented by CD1d...
  2. pmc Location, synthesis and function of glycolipids and polyglycerolphosphate lipoteichoic acid in Gram-positive bacteria of the phylum Firmicutes
    Nathalie T Reichmann
    Section of Microbiology, Imperial College London, South Kensington Campus, London, UK
    FEMS Microbiol Lett 319:97-105. 2011
    ..Furthermore, we will reintroduce the idea that LTA remains in close proximity to the bacterial membrane for its function during bacterial growth rather than as a surface-exposed structure...
  3. pmc Elevated globotriaosylsphingosine is a hallmark of Fabry disease
    Johannes M Aerts
    Amsterdam Lysosome Center, Departments of Medical Biochemistry, Internal Medicine, and Paediatrics, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 105:2812-7. 2008
    ..Our findings suggest that measurement of circulating globotriaosylsphingosine will be useful to monitor Fabry disease and may contribute to a better understanding of the disorder...
  4. pmc Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
    Yuki Kinjo
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 12:966-74. 2011
    ..Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, ..
  5. ncbi Quorum sensing and swarming migration in bacteria
    Ruth Daniels
    Centre of Microbial and Plant Genetics, K U Leuven, Kasteelpark Arenberg 20, 3001 Heverlee, Belgium
    FEMS Microbiol Rev 28:261-89. 2004
    ..Here we also describe how quorum sensing may disperse existing biofilms and control the interaction between bacteria and higher organisms (such as the Rhizobium-bean symbiosis)...
  6. pmc Rhamnolipids: diversity of structures, microbial origins and roles
    Ahmad Mohammad Abdel-Mawgoud
    INRS Institut Armand Frappier, 531 Boulevard des Prairies, Laval, QC, H7V 1B7, Canada
    Appl Microbiol Biotechnol 86:1323-36. 2010
    ....
  7. pmc Two-enzyme systems for glycolipid and polyglycerolphosphate lipoteichoic acid synthesis in Listeria monocytogenes
    Alexander J Webb
    Department of Microbiology, Imperial College London, London, UK
    Mol Microbiol 74:299-314. 2009
    ..Inactivation of LtaS leads to severe growth and cell division defects, underscoring the pivotal role of LTA in this gram-positive pathogen...
  8. ncbi Schistosoma mansoni worm glycolipids induce an inflammatory phenotype in human dendritic cells by cooperation of TLR4 and DC-SIGN
    Caroline M W van Stijn
    VU University Medical Center, Van den Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Mol Immunol 47:1544-52. 2010
    ..We show here that Schistosoma mansoni worm glycolipids induce DC activation as indicated by upregulation of the maturation markers CD80, CD86 and MHC-II, as well as ..
  9. ncbi Small-molecule pheromones that control dauer development in Caenorhabditis elegans
    Rebecca A Butcher
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, Massachusetts 02115, USA
    Nat Chem Biol 3:420-2. 2007
    ..The identification of dauer pheromone components 1 and 2 will facilitate the identification of target receptors and downstream signaling proteins...
  10. pmc High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling
    Priscille Brodin
    Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Seongbuk gu, Seoul, Korea
    PLoS Pathog 6:e1001100. 2010
    ..the mutants in Rv1503c and Rv1506c were perturbed in the biosynthesis of acyltrehalose-containing glycolipids. Our results suggest that such glycolipids indeed play a critical role in the early intracellular fate of the ..
  11. pmc Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant
    Xiangming Li
    Aaron Diamond AIDS Research Center, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 107:13010-5. 2010
    ..Through this rigorous and iterative screening process, we have identified a lead candidate glycolipid, 7DW8-5, that exhibits a superior adjuvant effect than alpha-GalCer on HIV and malaria vaccines in mice...
  12. ncbi Oligosaccharide microarrays for high-throughput detection and specificity assignments of carbohydrate-protein interactions
    Shigeyuki Fukui
    Glycosciences Laboratory, Imperial College Faculty of Medicine, Northwick Park Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Nat Biotechnol 20:1011-7. 2002
    ..The arrays are obtained from glycoproteins, glycolipids, proteoglycans, polysaccharides, whole organs, or from chemically synthesized oligosaccharides...
  13. pmc Structural characterization and anti-HSV-1 and HSV-2 activity of glycolipids from the marine algae Osmundaria obtusiloba isolated from Southeastern Brazilian coast
    Lauro M de Souza
    Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba 81531 990, PR, Brazil
    Mar Drugs 10:918-31. 2012
    b>Glycolipids were extracted from the red alga Osmundaria obtusiloba from Southeastern Brazilian coast...
  14. pmc Rhamnolipid surfactant production affects biofilm architecture in Pseudomonas aeruginosa PAO1
    Mary E Davey
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    J Bacteriol 185:1027-36. 2003
    ..We propose that the maintenance of biofilm architecture represents a previously unrecognized step in the development of these microbial communities...
  15. pmc MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence
    Scott E Converse
    Department of Microbiology and Immunology, G W Hooper Foundation, University of California, San Francisco 94143, USA
    Proc Natl Acad Sci U S A 100:6121-6. 2003
    ....
  16. ncbi Structure and function of glycoglycerolipids in plants and bacteria
    Georg Hölzl
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Prog Lipid Res 46:225-43. 2007
    ....
  17. pmc Shiga toxin binding to glycolipids and glycans
    Karen M Gallegos
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e30368. 2012
    ..The glycolipid globotriaosylceramide (Gb3) has been reported to be the receptor for both toxins. While there is considerable data to suggest that Gb3 can bind Stx1, binding of Stx2 to Gb3 is variable...
  18. pmc Both phthiocerol dimycocerosates and phenolic glycolipids are required for virulence of Mycobacterium marinum
    Jia Yu
    Key Laboratory of Medical Molecular Virology, Institute of Biomedical Sciences and Medical Microbiology, Fudan University, Shanghai, China
    Infect Immun 80:1381-9. 2012
    Phthiocerol dimycocerosates (PDIMs) and structurally related phenolic glycolipids (PGLs) are complex cell wall lipids unique to pathogenic mycobacteria...
  19. pmc Glycolipids that elicit IFN-γ-biased responses from natural killer T cells
    Aaron J Tyznik
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Chem Biol 18:1620-30. 2011
    Natural killer T (NKT) cells recognize glycolipids presented by CD1d. The first antigen described, α-galactosyl ceramide (αGalCer), is a potential anticancer agent whose activity depends upon IFN-γ secretion...
  20. pmc Deletion of the glycosyltransferase bgsB of Enterococcus faecalis leads to a complete loss of glycolipids from the cell membrane and to impaired biofilm formation
    Christian Theilacker
    University Medical Center Freiburg, Germany
    BMC Microbiol 11:67. 2011
    ..Here we analyzed the function of a putative glucosyltransferase EF2890 designated biofilm-associated glycolipid synthesis B (bgsB) immediately downstream of bgsA...
  21. pmc Methylation of GPLs in Mycobacterium smegmatis and Mycobacterium avium
    Dharshini Jeevarajah
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Bacteriol 186:6792-9. 2004
    ..The GPLs are glycolipids that contain modified sugars including acetylated 6-deoxy-talose and methylated rhamnose...
  22. ncbi Mapping fucosylated epitopes on glycoproteins and glycolipids of Schistosoma mansoni cercariae, adult worms and eggs
    M L M Robijn
    Department of Parasitology, Centre of Infectious Diseases, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    Parasitology 130:67-77. 2005
    ..Lewis X was found both on glycolipids and glycoproteins, yet with completely different expression patterns during the life-cycle: on glycolipids, ..
  23. ncbi A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response
    Michael B Reed
    Tuberculosis Research Section, NIAID, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA
    Nature 431:84-7. 2004
    ..Furthermore, the overproduction of PGL by M. tuberculosis or the addition of purified PGL to monocyte-derived macrophages was found to inhibit the release of these pro-inflammatory mediators in a dose-dependent manner...
  24. pmc Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity
    Ya Jen Chang
    Division of Immunology and Allergy, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 121:57-69. 2011
    ..These findings suggest what we believe to be a novel pathway that can regulate AHR, and a new therapeutic strategy (treatment with glycolipid activators of this NKT cell population) for asthma...
  25. ncbi Self-produced extracellular stimuli modulate the Pseudomonas aeruginosa swarming motility behaviour
    Julien Tremblay
    INRS Institut Armand Frappier, Laval Quebec, H7V 1B7, Canada
    Environ Microbiol 9:2622-30. 2007
    ..We propose a model explaining how HAAs and di-RLs together modulate the behaviour of swarming migrating cells by acting as self-produced negative and positive chemotactic-like stimuli...
  26. ncbi The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids
    S A Porcelli
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Annu Rev Immunol 17:297-329. 1999
    ..by CD1 has revealed the surprising finding that these are predominantly a variety of foreign lipids and glycolipids, including several found prominently in the cell walls and membranes of pathogenic mycobacteria...
  27. pmc Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids
    Ya Jen Chang
    Genomics Research Center, Academia Sinica, Taipei 115, Taiwan
    Proc Natl Acad Sci U S A 104:10299-304. 2007
    ..In vitro, glycolipids containing an aromatic ring in their acyl tail or sphingosine tail were more effective than alpha-GalCer in ..
  28. pmc A Staphylococcus aureus ypfP mutant with strongly reduced lipoteichoic acid (LTA) content: LTA governs bacterial surface properties and autolysin activity
    Iris Fedtke
    Cellular and Molecular Microbiology Division, University of Tubingen, Department of Medical Microbiology and Hygiene, 72076 Tubingen, Germany
    Mol Microbiol 65:1078-91. 2007
    ..We propose to consider LTA and its biosynthetic enzymes as targets for new antibiofilm strategies...
  29. pmc Multiple roles of biosurfactants in structural biofilm development by Pseudomonas aeruginosa
    Sünje Johanna Pamp
    Centre for BioScience Technology, BioCentrum DTU, Building 301, The Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Bacteriol 189:2531-9. 2007
    ..aeruginosa biofilms demonstrated that the wild-type and rhlA and pilA mutant strains formed distinct subpopulations on top of each other dependent on their ability to migrate and produce biosurfactants...
  30. pmc Rhamnolipids modulate swarming motility patterns of Pseudomonas aeruginosa
    Nicky C Caiazza
    Department of Microbiology and Immunology, Rm 505, Vail Building, Dartmouth Medical School, Hanover, NH 03755, USA
    J Bacteriol 187:7351-61. 2005
    ..The abilities to produce and respond to rhamnolipids in the context of group behavior are discussed...
  31. ncbi Fumonisin B1 exposure and its selective effect on porcine jejunal segment: sphingolipids, glycolipids and trans-epithelial passage disturbance
    Nicolas Loiseau
    Laboratoire de Pharmacologie et Toxicologie UR66, INRA, F 31931 Toulouse, France
    Biochem Pharmacol 74:144-52. 2007
    ..as demonstrated by an increase of the amount of free sphingoid bases in a time- and dose-dependent manner, (ii) a depletion of the glycolipids in plasma membranes is observed, and (iii) an increase occurs in the trans-epithelial flux.
  32. pmc Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells
    Barbara A Sullivan
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 184:141-53. 2010
    ..Therefore, we suggest that the pharmacokinetic properties of glycolipids are a major determinant of cytokine skewing, suggesting a pathway for designing therapeutic glycolipids for ..
  33. ncbi Candida albicans phospholipomannan is sensed through toll-like receptors
    Thierry Jouault
    Laboratoire de Mycologie Fondamentale et Appliquée, Inserm EMI0360, Universite de Lille II, Lille, France
    J Infect Dis 188:165-72. 2003
    ..albicans, and the recognition of PLM by TLRs, together with the unique pathogenic potential of C. albicans, suggests that this molecule may be a member of the pathogen-associated molecular pattern family...
  34. ncbi Immune sensing of Aspergillus fumigatus proteins, glycolipids, and polysaccharides and the impact on Th immunity and vaccination
    Silvia Bozza
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 183:2407-14. 2009
    ..In this study, we have comparatively assessed secreted- and membrane-anchored proteins, glycolipids, and polysaccharides for the ability to induce vaccine-dependent protection in transplanted mice and Th ..
  35. ncbi Roles of the acidic lipids sulfoquinovosyl diacylglycerol and phosphatidylglycerol in photosynthesis: their specificity and evolution
    Norihiro Sato
    School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192 0392, Japan
    J Plant Res 117:495-505. 2004
    ..Here, roles of these acidic lipids are discussed with a focus on their specificity and the evolution of photosynthetic membranes...
  36. pmc Hypervirulence of a rough variant of the Mycobacterium abscessus type strain
    E Catherinot
    Laboratoire de Microbiologie, Hopital Raymond Poincare, 104 Bd Raymond Poincaré, 92380 Garches, France
    Infect Immun 75:1055-8. 2007
    ..We show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for C57BL/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by murine monocyte-derived macrophages...
  37. ncbi Harnessing invariant NKT cells in vaccination strategies
    Vincenzo Cerundolo
    Tumour Immunology Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DU, UK
    Nat Rev Immunol 9:28-38. 2009
    ..In addition, we describe structural and kinetic analyses that assist in the design of optimal iNKT-cell agonists that could be used in the clinical setting as vaccine adjuvants...
  38. pmc Simple and fast lateral flow test for classification of leprosy patients and identification of contacts with high risk of developing leprosy
    S Buhrer-Sekula
    KIT Royal Tropical Institute Biomedical Research, 1105 AZ Amsterdam, The Netherlands
    J Clin Microbiol 41:1991-5. 2003
    ..leprae. It does not require any special equipment, and the highly stable reagents make the test robust and suitable for use in tropical countries...
  39. ncbi DC-SIGN mediates binding of dendritic cells to authentic pseudo-LewisY glycolipids of Schistosoma mansoni cercariae, the first parasite-specific ligand of DC-SIGN
    Sandra Meyer
    Institute of Biochemistry, Medical Faculty, Justus Liebig University Giessen, Germany
    J Biol Chem 280:37349-59. 2005
    ..Here we report that the CLR DC-SIGN mediates adhesion of DCs to authentic glycolipids derived from Schistosoma mansoni cercariae and their excretory/secretory products...
  40. ncbi Anionic lipids are required for chloroplast structure and function in Arabidopsis
    Bin Yu
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 1319, USA
    Plant J 36:762-70. 2003
    Photosynthetic membranes of plants primarily contain non-phosphorous glycolipids. The exception is phosphatidylglycerol (PG), which is an acidic/anionic phospholipid...
  41. ncbi Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa
    Peter Ø Jensen
    Department of Clinical Microbiology, Rigshospitalet, DK 2100 Copenhagen Ø, Denmark
    Microbiology 153:1329-38. 2007
    ..aeruginosa by disabling the PMNs, which are a major first line of defence of the host. Furthermore, the study emphasizes the inhibition of QS as a target for the treatment of infections with P. aeruginosa...
  42. ncbi Urinary globotriaosylsphingosine-related biomarkers for Fabry disease targeted by metabolomics
    Christiane Auray-Blais
    Service of Genetics, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Anal Chem 84:2745-53. 2012
    ..None of these biomarkers were detected in controls. To our knowledge, this is the first time that lyso-Gb(3)-related Fabry disease biomarkers are detected in urine...
  43. ncbi Plasma globotriaosylsphingosine: diagnostic value and relation to clinical manifestations of Fabry disease
    S M Rombach
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Biochim Biophys Acta 1802:741-8. 2010
    ..LysoGb3 is an independent risk factor for development of cerebrovascular white matter lesions in male patients and left ventricular hypertrophy in females. Disease severity correlates with exposure to plasma lysoGb3...
  44. pmc Immunology in the clinic review series; focus on cancer: glycolipids as targets for tumour immunotherapy
    L G Durrant
    Academic Department of Clinical Oncology, Molecular Medical Sciences, City Hospital, University of Nottingham, Nottingham, UK
    Clin Exp Immunol 167:206-15. 2012
    Research into aberrant glycosylation and over-expression of glycolipids on the surface of the majority of cancers, coupled with a knowledge of glycolipids as functional molecules involved in a number of cellular physiological pathways, ..
  45. ncbi Early signal transduction induced by Candida albicans in macrophages through shedding of a glycolipid
    T Jouault
    Unite INSERM 42, Domaine du CERTIA, Villeneuve d Ascq, France
    J Infect Dis 178:792-802. 1998
    ..All of these results demonstrate that C. albicans phospholipomannan shedding is involved in C. albicans-macrophage interaction through beta-1,2-oligomannosides...
  46. pmc The human epithelial carcinoma antigen recognized by monoclonal antibody AE3 is expressed on a sulfoglycolipid in addition to neoplastic mucins
    Angelina S Palma
    Glycosciences Laboratory, Department of Medicine, Imperial College London, Northwick Park and St Marks Campus, Watford Road, Harrow, Middlesex, UK
    Biochem Biophys Res Commun 408:548-52. 2011
    ..The microarrays encompassed a series of 492 sequence-defined glycan probes in the form of glycolipids and neoglycolipids...
  47. ncbi Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins
    Tetsuya Okuda
    Department of Biochemistry II, Nagoya University School of Medicine, Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biol Chem 281:10230-5. 2006
    ..The lethal kinetics were similar regardless of lipopolysaccharide elimination in VT preparation, suggesting that basal Gb3/CD77 levels are sufficient for lethal effects of VTs...
  48. ncbi Lipids of pathogenic Mycobacteria: contributions to virulence and host immune suppression
    L Guenin-Macé
    Institut Pasteur, Unité Postulante Pathogénomique Mycobactérienne Intégrée, Paris, France
    Transbound Emerg Dis 56:255-68. 2009
    ..Here, the chemical structure, host cell receptors and biological actions of this emerging class of mycobacterial virulence factors are reviewed...
  49. ncbi Glyco- and sphingophosphonolipids from the medusa Phyllorhiza punctata: NMR and ESI-MS/MS fingerprints
    Lauro M de Souza
    Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Parana, CP 19046, CEP 81531 990, Curitiba, PR, Brazil
    Chem Phys Lipids 145:85-96. 2007
    ..Two different groups of glycolipids and a sphingolipid were isolated by silica-gel column chromatography and characterized using GC-MS, ESI-MS, 1D, ..
  50. pmc Synthesis of a versatile building block for the preparation of 6-N-derivatized α-galactosyl ceramides: rapid access to biologically active glycolipids
    Peter J Jervis
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Org Chem 76:320-3. 2011
    ..Biologically active glycolipids 6 and 8 have been synthesized to illustrate the applicability of the approach.
  51. ncbi MmpS4 promotes glycopeptidolipids biosynthesis and export in Mycobacterium smegmatis
    Caroline Deshayes
    INSERM UMR 570, Unité de Pathogénie des Infections Systémiques, Paris Cedex 15, F 75730, France
    Mol Microbiol 78:989-1003. 2010
    ..MmpS4 in Mycobacterium smegmatis is required for the production and export of large amounts of cell surface glycolipids, but is dispensable for biosynthesis per se...
  52. pmc Prospective study of serological conversion as a risk factor for development of leprosy among household contacts
    J T Douglas
    Department of Microbiology, University of Hawaii, Honolulu, HI 96822, USA
    Clin Diagn Lab Immunol 11:897-900. 2004
    ..Seropositive household contacts had a significantly higher risk of developing leprosy (relative hazard adjusted for age and sex [aRH], 7.2), notably multibacillary leprosy (aRH = 24), than seronegative contacts...
  53. pmc The phenolic glycolipid of Mycobacterium tuberculosis differentially modulates the early host cytokine response but does not in itself confer hypervirulence
    Daniel Sinsimer
    Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute Center, University of Medicine and Dentistry of New Jersey, 225 Warren St, Newark, NJ 07103, USA
    Infect Immun 76:3027-36. 2008
    ..tuberculosis, it probably acts in concert with other bacterial factors which seem to be dependent on the background of the strain...
  54. pmc Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid
    Kelly S Doran
    Department of Pediatrics, Division of Infectious Diseases, UCSD School of Medicine, La Jolla, California 92093, USA
    J Clin Invest 115:2499-507. 2005
    ..Our data suggest that LTA expression on the GBS surface plays a role in bacterial interaction with BBB endothelium and the pathogenesis of neonatal meningitis...
  55. pmc A molecular mechanism that stabilizes cooperative secretions in Pseudomonas aeruginosa
    Joao B Xavier
    Center for Systems Biology, Harvard University, 52 Oxford St, Cambridge, MA 02138, USA
    Mol Microbiol 79:166-79. 2011
    ..More generally, prudent regulation is a mechanism to stabilize cooperation...
  56. pmc Novel interactions of glycosaminoglycans and bacterial glycolipids mediate binding of enterococci to human cells
    Irina G Sava
    Division of Infectious Diseases, University Medical Center Freiburg, 79106 Freiburg, Germany
    J Biol Chem 284:18194-201. 2009
    ....
  57. ncbi Neoglycolipid technology: deciphering information content of glycome
    Wengang Chai
    MRC Glycosciences Laboratory, Imperial College London, Northwick Park Hospital Campus, Harrow, Middlesex, HA1 3UJ, United Kingdom
    Methods Enzymol 362:160-95. 2003
  58. ncbi Neoglycolipid probes prepared via oxime ligation for microarray analysis of oligosaccharide-protein interactions
    Yan Liu
    Glycosciences Laboratory, Imperial College London, Northwick Park and St Mark s Campus, Harrow, Middlesex HA1 3UJ, United Kingdom
    Chem Biol 14:847-59. 2007
    ....
  59. ncbi Biosynthesis and functions of the plant sulfolipid
    Mie Shimojima
    Center for Biological Resources and Informatics, Tokyo Institute of Technology, 4259 B65 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Prog Lipid Res 50:234-9. 2011
    ..This review summarizes recent research defining the mechanism for SQDG biosynthesis and its biological function in higher plants, particularly under phosphate-starved conditions...
  60. pmc Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements
    Else Marie Agger
    Adjuvant Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 3:e3116. 2008
    ..The development of new adjuvants capable of inducing highly complex immune responses with strong antigen-specific T-cell responses in addition to antibodies is therefore urgently needed...
  61. pmc A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components
    Rebecca A Butcher
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:14288-92. 2008
    ....
  62. ncbi Spontaneous reversion of Mycobacterium abscessus from a smooth to a rough morphotype is associated with reduced expression of glycopeptidolipid and reacquisition of an invasive phenotype
    Susan T Howard
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Microbiology 152:1581-90. 2006
    ..These results indicate that the ability to switch between smooth and rough morphologies may allow M. abscessus to transition between a colonizing phenotype and a more virulent, invasive form...
  63. ncbi Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria
    Yuki Kinjo
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Immunol 7:978-86. 2006
    ..Here we show that mouse and human NKT cells also recognized glycolipids, specifically a diacylglycerol, from Borrelia burgdorferi, which causes Lyme disease. The B...
  64. pmc Two types of MGDG synthase genes, found widely in both 16:3 and 18:3 plants, differentially mediate galactolipid syntheses in photosynthetic and nonphotosynthetic tissues in Arabidopsis thaliana
    K Awai
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama, Kanagawa 226 8501, Japan
    Proc Natl Acad Sci U S A 98:10960-5. 2001
    ..e., in inflorescence (atMGD2) and roots (atMGD3), where they conceivably influence the eukaryotic structure prominence in MGDG. In addition, their expression of type B enzymes is enhanced under phosphate deprivation...
  65. pmc Saccharomyces cerevisiae-based molecular tool kit for manipulation of genes from gram-negative bacteria
    Robert M Q Shanks
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Appl Environ Microbiol 72:5027-36. 2006
    ..These tools can be used for genetic studies of pseudomonads and many other gram-negative bacteria...
  66. pmc Mycobacterium tuberculosis cell wall glycolipids directly inhibit CD4+ T-cell activation by interfering with proximal T-cell-receptor signaling
    Robert N Mahon
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University and University Hospitals, Case Medical Center, 10900 Euclid Avenue, BRB 1010B, Cleveland, OH 44106 4984, USA
    Infect Immun 77:4574-83. 2009
    ..tuberculosis. Fractionation identified that M. tuberculosis cell wall glycolipids, specifically, phosphatidylinositol mannoside and mannose-capped lipoarabinomannan, were potent inhibitors...
  67. pmc The mycobacterial glycopeptidolipids: structure, function, and their role in pathogenesis
    Jeffrey S Schorey
    Department of Biological Sciences, Eck Institute for Global Health and Infectious Diseases, University of Notre Dame, Notre Dame, IN 46556, USA
    Glycobiology 18:832-41. 2008
    Glycopeptidolipids (GPLs) are a class of glycolipids produced by several nontuberculosis-causing members of the Mycobacterium genus including pathogenic and nonpathogenic species...
  68. ncbi Activation of invariant natural killer T cells by synthetic glycolipid ligands suppresses autoantibody-induced arthritis
    Shinjiro Kaieda
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Arthritis Rheum 56:1836-45. 2007
    ..This study was designed to evaluate the protective effects of SGL-S23 in an effector phase of arthritis...
  69. ncbi Glycolipids are involved in biofilm accumulation and prolonged bacteraemia in Enterococcus faecalis
    Christian Theilacker
    Division of Infectious Diseases, Department of Medicine, University Medical Center Freiburg, Germany
    Mol Microbiol 71:1055-69. 2009
    ..In several Gram-positive bacteria, membrane glycolipids have been implicated in biofilm formation...
  70. pmc Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa
    U A Ochsner
    Institute for Biotechnology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich
    J Bacteriol 176:2044-54. 1994
    ..Additionally, such PG201::'rhlR' mutant strains lacked elastase activity, indicating that the RhlR protein is a pleiotropic regulator...
  71. ncbi Characterization of three glycosyltransferases involved in the biosynthesis of the phenolic glycolipid antigens from the Mycobacterium tuberculosis complex
    Esther Perez
    Département Mécanismes Moléculaires des Infections Mycobactériennes, Institut de Pharmacologie et Biologie Structurale, CNRS and Université Paul Sabatier Unité Mixte de Recherche 5089, 205 route de Narbonne, 31077 Toulouse Cedex, France
    J Biol Chem 279:42574-83. 2004
    ..The recombinant strains produced provide the tools to study the role of the carbohydrate domain of PGL-tb and p-HBAD in M. tuberculosis pathogenesis...
  72. ncbi Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes
    Morten Alhede
    Department of Systems Biology, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Microbiology 155:3500-8. 2009
    ..Our data strengthen the view that cross-kingdom communication plays a key role in P. aeruginosa recognition and evasion of the host defence...
  73. ncbi Reduction of elevated plasma globotriaosylsphingosine in patients with classic Fabry disease following enzyme replacement therapy
    Marielle J van Breemen
    Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands
    Biochim Biophys Acta 1812:70-6. 2011
    ..Our investigation revealed that ERT of Fabry patients reduces plasma lysoGb3, regardless of the recombinant enzyme used. This finding shows that ERT can correct a characteristic biochemical abnormality in Fabry patients...
  74. pmc PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis
    Stavroula K Hatzios
    Department of Chemistry and Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA
    J Biol Chem 284:12745-51. 2009
    ..of trehalose with two palmitoyl groups, generating a diacylated product similar to the 2,3-diacyltrehalose glycolipids of M. tuberculosis...
  75. ncbi Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes
    N Burdin
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 161:3271-81. 1998
    Mouse CD1 (mCD1) glycoproteins are known to present peptides, while human CD1 molecules present glycolipids. In mice, mCD1-autoreactive NK T cells play critical roles in various immune responses, through the secretion of high amounts of ..
  76. ncbi Plasma globotriaosylsphingosine as a biomarker of Fabry disease
    Tadayasu Togawa
    Department of Analytical Biochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo 204 8588, Japan
    Mol Genet Metab 100:257-61. 2010
    ..The plasma lyso-Gb3 level in the Fabry patient who had received ERT was elevated at the baseline and fell more dramatically on ERT than that of Gb3. Plasma lyso-Gb3 could thus be a potential biomarker of Fabry disease...
  77. pmc Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia
    Marie Laure Michel
    Unité Mixte de Recherche 8147, Centre National de la Recherche Scientifique, Faculté de Médecine René Descartes, Paris V, Hopital Necker, Paris, Cedex 15, France
    J Exp Med 204:995-1001. 2007
    ..upon synthetic (alpha-galactosylceramide [alpha-GalCer] or PBS-57), as well as natural (lipopolysaccharides or glycolipids derived from Sphingomonas wittichii and Borrelia burgdorferi), ligand stimulation. NK1...
  78. ncbi Globotriaosylsphingosine actions on human glomerular podocytes: implications for Fabry nephropathy
    Maria D Sanchez-Niño
    Nefrologia, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid and Instituto Reina Sofia de Investigaciones Nefrológicas IRSIN, Madrid, Spain
    Nephrol Dial Transplant 26:1797-802. 2011
    ....
  79. ncbi Glycosidase-induced fusion of isoprenoid gentiobiosyl lipid membranes at acidic pH
    G Dennis Sprott
    Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Ottawa, ON K1A OR6, Canada
    Glycobiology 19:267-76. 2009
    ..Radiotracer and (1)H NMR studies revealed that glycolipids in fused archaeosomes were not degraded significantly by glucosidase treatment during fusion...
  80. ncbi The fidelity, occasional promiscuity, and versatility of T cell receptor recognition
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Immunity 28:304-14. 2008
    ..Collectively, these studies have revealed the versatility of the TCR in recognizing the distinct yet evolutionarily related proteinaceous and lipid-presenting molecules of the immune system...
  81. pmc Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes
    Guillaume Tabouret
    CNRS, IPBS Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
    PLoS Pathog 6:e1001159. 2010
    ..PGL-1 production also promoted bacterial uptake by human dendritic cells and dampened their infection-induced maturation. Our results therefore suggest that M. leprae produces PGL-1 for immune-silent invasion of host phagocytic cells...
  82. ncbi A null mutant of Synechococcus sp. PCC7942 deficient in the sulfolipid sulfoquinovosyl diacylglycerol
    S Guler
    Institut für Genbiologische Forschung Berlin GmbH, Federal Republic of Germany
    J Biol Chem 271:7501-7. 1996
    ..However, reduced growth of the mutant under phosphate-limiting conditions supports the hypothesis that sulfolipid acts as a surrogate for anionic phospholipids under phosphate-limiting growth conditions...
  83. pmc CD1b-mediated T cell recognition of a glycolipid antigen generated from mycobacterial lipid and host carbohydrate during infection
    D B Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:965-76. 2000
    T cells recognize microbial glycolipids presented by CD1 proteins, but there is no information regarding the generation of natural glycolipid antigens within infected tissues...
  84. ncbi Inhibitory effects of glycolipids fraction from spinach on mammalian DNA polymerase activity and human cancer cell proliferation
    Isoko Kuriyama
    Department of Nutritional Science, Laboratory of Food and Nutritional Sciences, Kobe Gakuin University, Kobe, Hyogo 651 2180, Japan
    J Nutr Biochem 16:594-601. 2005
    We succeeded in purifying the fraction containing the major glycolipids in monogalactosyl diacylglycerol, digalactosyl diacylglycerol and sulfoquinovosyl diacylglycerol (SQDG) from dried vegetables...
  85. pmc Ascaroside expression in Caenorhabditis elegans is strongly dependent on diet and developmental stage
    Fatma Kaplan
    Center for Medical, Agricultural and Veterinary Entomology, USDA ARS, Gainesville, Florida, United States of America
    PLoS ONE 6:e17804. 2011
    ..Thus, ascarosides have multiple functions. Until now, it has been generally assumed that ascarosides are constitutively expressed during nematode development...
  86. ncbi A subset of human pancreatic beta cells express functional CD14 receptors: a signaling pathway for beta cell-related glycolipids, sulfatide and β-galactosylceramide
    Thomas Osterbye
    Bartholin Instituttet, Rigshospitalet, Biocenter Copenhagen, Copenhagen N, Denmark
    Diabetes Metab Res Rev 26:656-67. 2010
    ..Multiple factors may contribute to the development of T1DM. Among these, the metabolic state of beta-cells and pro-inflammatory cytokines, produced by infiltrating immune cells, have been implicated in the precipitation of T1DM...
  87. pmc Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a beta-linked self-glycolipid
    Philomena Arrenberg
    Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 107:10984-9. 2010
    TCR-mediated recognition of beta-linked self-glycolipids bound to CD1d is poorly understood...
  88. pmc Comparative metabolomics reveals biogenesis of ascarosides, a modular library of small-molecule signals in C. elegans
    Stephan H von Reuss
    Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    J Am Chem Soc 134:1817-24. 2012
    ..Our screen further demonstrates that ascaroside biosynthesis is directly affected by nutritional status and that excretion of the final products is highly selective...
  89. ncbi Fatty acyl structures of mycobacterium tuberculosis sulfoglycolipid govern T cell response
    Julie Guiard
    Département Mécanismes Moléculaires des Infections Mycobactériennes, Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
    J Immunol 182:7030-7. 2009
    ..These studies have major implications for the design of sulfoglycolipid analogs with potential use as tuberculosis subunit vaccines...
  90. ncbi The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production
    Malou Henriksen-Lacey
    School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK
    J Control Release 154:131-7. 2011
    ....
  91. ncbi Immune responses induced by spirochetal outer membrane lipoproteins and glycolipids
    Nicolas W J Schröder
    Department for Dermatology and Allergology, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Immunobiology 213:329-40. 2008
    ..However, there is increasing evidence that next to lipoproteins, glycolipids may also play an important role in responses of the immune system towards spirochetes...
  92. pmc Mutational analysis of cell wall biosynthesis in Mycobacterium avium
    Jean Pierre Laurent
    Seattle Biomedical Research Institute, Seattle, Washington 98109, USA
    J Bacteriol 185:5003-6. 2003
    ..Nineteen such mutants were isolated and mapped, including 10 with insertions in a functional island of cell wall biosynthetic genes that spans approximately 40 kb of the M. avium genome...
  93. pmc Increase in rhamnolipid synthesis under iron-limiting conditions influences surface motility and biofilm formation in Pseudomonas aeruginosa
    Rivka Glick
    The Bacterial Biofilm Research Laboratory, The Institute for Nanotechnology and Advanced Materials, The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Bacteriol 192:2973-80. 2010
    ..These results highlight the importance of biosurfactant production in determining the mature structure of P. aeruginosa biofilms under iron-limiting conditions...
  94. pmc How cholesterol constrains glycolipid conformation for optimal recognition of Alzheimer's beta amyloid peptide (Abeta1-40)
    Nouara Yahi
    Université Paul Cézanne Aix Marseille 3, université de la Méditerranée Aix Marseille 2, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, CNRS UMR 6231, INRA USC 2027, Interactions Moléculaires et Systèmes Membranaires, Faculté des Sciences Saint Jérôme, Marseille, France
    PLoS ONE 5:e9079. 2010
    ..These data shed some light on the complex molecular interplay between cell surface GSLs, cholesterol and Abeta peptides, and on the influence of this molecular ballet on Abeta-membrane interactions...
  95. pmc A glycosyltransferase involved in biosynthesis of triglycosylated glycopeptidolipids in Mycobacterium smegmatis: impact on surface properties
    Caroline Deshayes
    INSERM UMR570, Faculte de Medecine Necker Enfants Malades, 156 rue de Vaugirard, Paris Cedex 15, F 75730, France
    J Bacteriol 187:7283-91. 2005
    ..Glycopeptidolipids (GPLs) are species- or type species-specific glycolipids that are present at the surface of a number of mycobacteria and that are characterized by a high variability in ..
  96. ncbi Testis-specific sulfoglycolipid, seminolipid, is essential for germ cell function in spermatogenesis
    Yanlong Zhang
    Department of Molecular Genetics, Kochi University Medical School, Kochi 783 8505, Japan
    Glycobiology 15:649-54. 2005
    ....
  97. ncbi Acylated cholesteryl galactoside as a novel immunogenic motif in Borrelia burgdorferi sensu stricto
    Nicolas W J Schröder
    Institut für Mikrobiologie und Hygiene, Universitatsklinikum Charite, Medizinische Fakultat der Humboldt Universitat zu Berlin, Dorotheenstrasse 96, D 10117 Berlin, Germany
    J Biol Chem 278:33645-53. 2003
    ..Here we report on a novel class of immunogenic glycolipids purified from B. burgdorferi sensu stricto B31...
  98. ncbi Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli
    Liana Tsenova
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute, Newark, New Jersey 07103, USA
    J Infect Dis 192:98-106. 2005
    ....
  99. ncbi Stem cell glycolipids
    Makoto Yanagisawa
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street CA4040, Augusta, GA 30912, USA
    Neurochem Res 36:1623-35. 2011
    b>Glycolipids are compounds containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety...
  100. ncbi The impact of the absence of glycopeptidolipids on the ultrastructure, cell surface and cell wall properties, and phagocytosis of Mycobacterium smegmatis
    Gilles Etienne
    Institut de Pharmacologie et de Biologie Structurale, Unité Mixte de Recherche du Centre de National de Recherche Scientifique et de l Université Paul Sabatier UMR 5089, 205 route de Narbonne, 31077 Toulouse Cedex 04, France
    Microbiology 148:3089-100. 2002
    ..smegmatis. Altogether, these data showed that, in addition to being distinctive markers of numerous mycobacterial species, GPLs play a role in the bacterial phenotype, surface properties and cell wall permeability...
  101. ncbi Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia
    Roger G Linington
    Department of Chemistry, University of British Columbia, Vancouver, B C V6T 1Z1, Canada
    J Nat Prod 69:173-7. 2006
    ..fractionation of the crude extract led to the isolation of caminosides A (1) to D (4), a family of antimicrobial glycolipids. The structures of the three new caminosides B (2) to D (4) have been elucidated by spectroscopic analysis.

Research Grants70

  1. NKT Cells Immunotherapy: Targeting Dendritic Cells with Glycolipid Liposomes
    Peng Wang; Fiscal Year: 2007
    ..In contrast, a specialized subpopulation of T cells called NKT cells recognize glycolipids antigens presented by the MHC class l-like molecule; CD1d...
  2. Biofilm Infections in Postsurgical, Trauma, and Critically Ill Patients
    Carol L Wells; Fiscal Year: 2013
    ..on a surface and surrounded by a complex extracellular polymeric substance composed of proteins, glycoproteins, glycolipids, polysaccharides, and DNA...
  3. Phospholipid flip-flop in biogenic membranes
    Anant K Menon; Fiscal Year: 2013
    ..glycoproteins such as the neural cell adhesion molecule, GPI-anchored proteins such as acetylcholinesterase, glycolipids such as the receptor for cholera toxin, components of the cell walls of bacteria and yeast, and the O-antigen ..
  4. The Role of Glycolipids and CD1 in the Immunology of Leishmania Infection
    Laurence U Buxbaum; Fiscal Year: 2012
    ..NKT cells are activated by an unusual protein called CD1, which is involved in immune responses provoked by glycolipids (like GIPLs). The way in which CD1 and NKT cells work in infection is not well understood...
  5. Naturally Occurring IgM Anti-Leucocyte Autoantibodies Protect Against Renal IRI
    MARK DOUGLAS OKUSA; Fiscal Year: 2013
    ..Based on these findings we questioned whether IgM- ALA downregulate inflammation that accompanies renal IRI. Glycolipids released after ischemic injury are processed and presented by resident dendritic cells (DC), in presence of ..
  6. Biogenesis of lipoarabinomannan in mycobacteria
    Mary Jackson; Fiscal Year: 2013
    ..PIM) and their multiglycosylated counterparts, lipomannan (LM) and lipoarabinomannan (LAM) are complex glycolipids and lipoglycans found in the envelopes of all mycobacterial species...
  7. Hunting for Endogenous Ligands for Invariant Natural Killer T Cells
    Peng George Wang; Fiscal Year: 2010
    ..Accordingly, in this proposal, we hypothesize one type of glycolipids as the potential primary ligands based on the biosynthesis and degradation pathway of glycolipids in mouse and ..
  8. Design of CNS-Permeable Agents for the Treatment of Lipid Storage Diseases
    Scott D Larsen; Fiscal Year: 2010
    ..and Radin labs at the University of Michigan, have been widely used by many groups to probe the functions of glycolipids. One PDMP homologue, D-threo-ethylendioxyphenyl-2- octanoylamino-3-pyrrolidino-propanol, is currently in phase ..
  9. Structural Immunology of CD1 and CD1-TCR Complexes
    Dirk M Zajonc; Fiscal Year: 2013
    ..will structurally and functionally characterize differences in glycolipid recognition of Borrelia burgdorferi glycolipids by human and mouse NKT cells...
  10. Oligosaccharide moieties of human milk glycans that inhibit pathogens
    David S Newburg; Fiscal Year: 2013
    ..Glycans, including glycoproteins, glycolipids, mucins, and glycosaminoglycans, contain complex oligosaccharide structures attached to proteins, lipids, and ..
  11. MALDI-TOF/TOF MS TO SUPPORT BIOMEDICAL RESEARCH
    Catherine E Costello; Fiscal Year: 2012
    ..determinations of post-translationally modified proteins and structure elucidation of carbohydrates and glycolipids, and will enable imaging of 2-D samples, to support the human health-related projects described in this ..
  12. GLYCOSPHINGOLIPID METABOLISM AND MENTAL RETARDATION
    Glyn Dawson; Fiscal Year: 2013
    ..models of human disease, growth and development with innovative technology to better understand the role of glycolipids and sphingolipids in mental retardation, and to explain mechanisms of therapeutic reversal...
  13. The Role of Intrathecal Plasma Cell Clones in MS Pathogenesis
    GREGORY PARKS OWENS; Fiscal Year: 2013
    ..Multiple MS rAbs have been demonstrated to bind oligodendrocyte antigens and myelin- enriched glycolipids. Aim 1 will identify epitopes recognized by Abs derived from MS CSF plasma blasts and will develop antigen-..
  14. CD1 presentation of self glycolipids and lipopeptides to T cells
    DAVID BRANCH MOODY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): CD1 presentation of self glycolipids and lipopeptides to T cells T cells that recognize autoantigens play a central role in psoriasis, thyroiditis, diabetes, multiple sclerosis, rheumatoid arthritis ..
  15. Role of Nuclear Gangliosides in Neuronal Function
    Robert W Ledeen; Fiscal Year: 2012
    ..plasma membrane, but a number of intracellular mechanisms are now known to be mediated and modulated by these glycolipids. Our work has shown GM1 in particular to have a critical role regulating Ca2+ homeostasis in the nucleus and ..
  16. CELLULAR AND MOLECULAR MICROBIOLOGY TRAINING PROGRAM
    JACK J HAWIGER; Fiscal Year: 2010
    ..RNA and DNA Binding Proteins in Pathogen-Host Interaction;(ix) ER and Golgi Pathways for Microbial Peptides, Glycolipids, and Glycoproteins;and (x) Mitochondria and Microbial Strategy for Survival...
  17. Heterogeneity of T-cells in M. tuberculosis Infection
    HENRY BOOM; Fiscal Year: 2013
    ..First, ManLAM is one of the most abundant glycolipids in the MTB cell wall. Second, ManLAM travels outside the phagosome to interact with host cells...
  18. Epithelial Glycoconjugates as Barriers against Enteric Infections
    Nicholas J Mantis; Fiscal Year: 2013
    ..Pathogens affecting this age group commonly use lectin-like adhesins to adhere to host glycoproteins and glycolipids expressed on small intestinal enterocytes and/or M cells...
  19. PtdIns 4-Kinase Regulation of Protein Sorting in the Golgi Apparatus
    Kathryn M Ferguson; Fiscal Year: 2013
    ..provided by applicant): The Golgi apparatus has two primary functions: biosynthesis of glycoproteins and glycolipids, and sorting...
  20. Carbohydrate Antigenic Biomarkers for Epithelial Cancers
    Minoru Fukuda; Fiscal Year: 2013
    ..platform that we have established that presently includes more than 700 glycan sequences of glycoproteins and glycolipids. This will open the way to analysis of cancer patient sera for the presence of autoantibodies to F77 and AE3 ..
  21. New Frontiers at the Interface of Immunity and Glycobiology
    Andrew D Robertson; Fiscal Year: 2011
    ..by dendritic cells impacts our understanding of the innate immune response, while other findings reveal that glycolipids and bacterial polysaccharides can lead to NKT and T cell activation...
  22. Role of Sialic Acid Modification in ALL Survival and Drug Resistance
    NORA C HEISTERKAMP; Fiscal Year: 2013
    ..We hypothesize that ALL cells generate 9-O-acetylated, sialic acid-modified glycoproteins and glycolipids as a mechanism of protection against spontaneous and drug- induced apoptosis...
  23. Pathogenesis of Lupus Dermatitis
    Ram Raj Singh; Fiscal Year: 2013
    ..We will investigate whether 34 DETC in fact represent a novel subset of CD1d-reactive T cells, and CD1d-binding glycolipids increase 34 DETC, improve LC migration, and ameliorate lupus dermatitis...
  24. Recognition of microbes by NKT cells at the lung mucosal surface
    Dale T Umetsu; Fiscal Year: 2010
    ..In addition, we have shown that glycolipids from the bacterial species Sphingomonas can directly activate pulmonary NKT cells in mice and induce airway ..
  25. Role of Polymorphonuclear Phagocytes in Malaria Sepsis
    Ricardo Gazzinelli; Fiscal Year: 2010
    ..Furthermore, PMNs express TLR2, TLR4, and TLR9 that are critical for the innate immune response to Plasmodium glycolipids and DNA...
  26. Chemical Mycobacteriology
    Carolyn R Bertozzi; Fiscal Year: 2013
    ..b>Glycolipids of the outermost capsular layer are thought to contribute to host-pathogen interactions;their underlying ..
  27. NKT cells recognize and respond to microbes at mucosal surfaces
    Dale T Umetsu; Fiscal Year: 2010
    ..In addition, we have shown that glycolipids from the bacterial species Sphingomonas can directly activate pulmonary NKT cells in mice and induce airway ..
  28. BASEMENT MEMBRANE SELF-ASSEMBLY AND STRUCTURE
    PETER DANA YURCHENCO; Fiscal Year: 2013
    ..of BMs in different cell and organ culture systems has revealed that laminins adhere to cells through sulfated glycolipids, initiating BM assembly by polymerizing and binding to nidogen, type IV collagen, and proteoglycans...
  29. O-fucose Modified Notch as a Regulator of the Hematopoietic Stem Cell Homeostasis
    Lan Zhou; Fiscal Year: 2013
    ..modified to be conditionally deficient either in the expression of all fucose-carrying glycoproteins or glycolipids (FX-/-), or only O-linked fucosyl-glycans present on EGF repeats of a few proteins including Notch (conditional ..
  30. Ordered Membrane Domain Formation and Function in Pathogenic Bacteria
    Erwin London; Fiscal Year: 2013
    ..with the Benach and Brown labs, to understand the physical basis of domain organization of cholesteryl glycolipids and free cholesterol in Borrelia membranes, and to define the functional importance of these domains...
  31. Microenvironment-Leukemia Communication Through Lectins
    NORA C HEISTERKAMP; Fiscal Year: 2013
    ..and in particula cells of the immune system, are covered by a dense layer of carbohydrate-modified proteins and glycolipids, of which the function has not been explored...
  32. Antigen Specific Response to Borrelia
    Jorge L Benach; Fiscal Year: 2013
    ..Therefore, the contribution of the Borrelia cholesterol glycolipids to the bactericidal action of the antibodies will be studied, particularly in the context of the outer membrane ..
  33. Molecular Pharmacology of NKT Cell Agonists
    Luc Teyton; Fiscal Year: 2013
    ..Since, activators of NKT cells are glycolipids, it is most likely that lipoprotein and scavenger receptor polymorphism in human will heavily influence the ..
  34. Molecular Determinants of Endotoxin Interaction with Toll-like Receptor4
    Theresa Lee Gioannini; Fiscal Year: 2013
    ..Toll-like receptor 4 (TLR4) is essential for the recognition of even minute amounts of endotoxin (E), unique glycolipids abundantly present on the surface of Gram negative bacteria (GNB), that are responsible for host responses to ..
  35. Genetic analysis of the NKT cell response to Streptococcus pneumoniae
    JOSE LUIS VELA; Fiscal Year: 2010
    ..Work from our laboratory has identified the glycolipids on S...
  36. GLYCOLIPIDS AND EXPERIMENTAL NEUROPATHY
    Robert K Yu; Fiscal Year: 2012
    ..Potential antigens include a variety of acidic GSLs, such as gangliosides and sulfated glycolipids, and neutral GSLs...
  37. Endogenous glycosphingolipid antigens for NKT cells
    Dapeng Zhou; Fiscal Year: 2013
    ..insights into cellular lipidomics studies, with a specific focus on the important immunological functions of glycolipids. More than 10% of the genes in the human genome are used for lipid metabolism;thus, knowledge and experience ..
  38. Small Cell-Penetrating Glyco-Decoys Sidetrack Selectin Ligand Biosynthesis
    Khushi L Matta; Fiscal Year: 2013
    ..acceptor-substrate and thus diverts the synthesis of the glycan chains from endogenous glycoproteins and glycolipids to soluble ligands, which act as inhibitors of selection binding to cell-bound ligand...
  39. Synthesis and Screening of Bioactive Glycolipids
    Jacquelyn Gervay-Hague; Fiscal Year: 2012
    In order to study the role glycolipids play in cell processes, infectious and food borne diseases as well as in infant development, researchers require ready access to pure compounds...
  40. Lipid Homeostasis, Immunity and Atherosclerosis
    Catherine C Hedrick; Fiscal Year: 2013
    ..Endogenous glycolipids, most likely derived from oxidized lipoproteins, engulfed apoptotic cells, or induced by infection, are loaded ..
  41. Harnessing NKT Cell Activation by Glycolipids
    Amy R Howell; Fiscal Year: 2010
    ..A little more than a decade ago it was revealed that glycolipids, particularly )-galactosylceramides ()- GalCers), could activate NKT cells by serving as ligands to a newly ..
  42. Thermo TSQ Quantum Access Mass Spectrometer
    Yusuf Awni Hannun; Fiscal Year: 2010
    ..Major lipid classes include triacylglycerols, phospholipids, glycolipids, sphingolipids, sterols, waxes and fatty acids...
  43. Metabolic incorporation of photocrosslinking sugars to study sialoside function
    JENNIFER KOHLER; Fiscal Year: 2012
    ..sugars to discover and characterize binding interactions of sialic acid- modified glycoproteins and glycolipids. This technology relies on the synthetic preparation of photocrosslinking analogs of sialic acid or of its ..
  44. Innate Immune Receptors for Toxoplasma gondii
    Ricardo Gazzinelli; Fiscal Year: 2010
    ..including their glycosylphospatidylinositol (GPI) and glycosylinositolphospholipids (GIPLs) or other glycolipids, as determined by a lipidomic approach, to bind and signal human cells via TLRs...
  45. Regulation of MD-2 function and expression
    Jerrold P Weiss; Fiscal Year: 2013
    ..GNB) depends upon innate immune recognition of endotoxin (E), unique, abundant and generally conserved glycolipids of GNB. Optimal TLR4- dependent responses are exquisitely sensitive and robust, but also self-limited...
  46. Structure and function of peptide presentation by CD1d
    Dirk M Zajonc; Fiscal Year: 2013
    ..applicant): The immune system uses antigen receptors on T cells (TCRs) to detect antigens, such as peptides or glycolipids that are presented by antigen-presenting molecules present on the surface of antigen-presenting cells...
  47. CD1d/NKT-binding Glycolipids as an Adjuvant for a T cell-based Malaria Vaccine
    Moriya Tsuji; Fiscal Year: 2009
    ..of one hundred a-GalCer analogs that we have recently generated, and then select a smaller panel of candidate glycolipids based on the in vitro cytokine production profiles they elicit upon cultivation with murine or human NKT cells...
  48. CD1d/NKT-binding glycolipids in enhancing the immunogenicity of a malaria vaccine
    Moriya Tsuji; Fiscal Year: 2013
    ..GalCer, but not 7DW8-5, induced a systemic production of cytokines including IFN-? and IL-12, whereas both glycolipids induced a similar level of systemic cytokine production upon their intravenous administration...
  49. Establishing the Molecular Basis of Glycoconjugate Glycosylation
    James Prestegard; Fiscal Year: 2013
    ..tools for the synthesis of complex glycans, the detection of their existence on glycoproteins and glycolipids in cellular environments, and the monitoring of redistribution in the course of disease...
  50. BASEMENT MEMBRANE SELF-ASSEMBLY AND STRUCTURE
    PETER DANA YURCHENCO; Fiscal Year: 2012
    ..Two key interactions for BM formation were characterized, i.e. (a) laminin anchorageto cell surface sulfated glycolipids (sulfatides) mediated by binding to lys/arg loci (especially residues 1831-3) of the laminin alpha1LG4 domain ..
  51. Glycolipid metabolism in single cells
    Norman J Dovichi; Fiscal Year: 2011
    ..They will prepare a suite of fluorescently-labeled gangliosides and members of the globoseries of glycolipids. They will also verify that these reagents are substrates for endogenous enzymes in the biosynthetic and ..
  52. A Chemical Reporter Strategy to Probe Trehalose-Containing Metabolites in Mycobac
    BENJAMIN MICHAEL SWARTS; Fiscal Year: 2011
    ..an unusual cell wall that not only imparts drug resistance but also contains an abundance of trehalose-based glycolipids that are intimately involved in disease pathogenesis...
  53. Carbohydrate force fields for structure, dynamics and molecular recognition
    Alexander D MacKerell; Fiscal Year: 2013
    ..in our laboratory during the initial funding period to furanose containing disaccharides, glycoproteins and glycolipids, and carbohydrates that include non-hydroxyl functional groups...
  54. CELL ENTRY AND SPREAD BY POLYOMA VIRUS
    THOMAS LIVINGSTON BENJAMIN; Fiscal Year: 2010
    ..The Specific Aims are first to determine whether certain glycolipids constitute the only class of cell receptors for the virus or whether certain glycoproteins may also serve as ..
  55. Development of a Small Molecule Therapy for Metachromatic Leukodystrophy
    Brett E Crawford; Fiscal Year: 2012
    ..The lack of ASA activity leads to widespread accumulation of 3-O sulfated glycolipids in the lysosomes of cells...
  56. Workshops in Molecular and Cellular Glycoscience
    Michael Tiemeyer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The glycan (carbohydrate) components of the glycoproteins and glycolipids that adorn the surfaces of all eukaryotic cells, as well as the secreted glycoproteins produced by these cells, interact with ..
  57. Function and assembly of toxin-stabilized domains
    Anne K Kenworthy; Fiscal Year: 2013
    ..these questions though the following aims: 1) to test the hypothesis that CTxB must cluster raft-associated glycolipids to assemble stabilized raft domains;2) to determine how toxin-stabilized rafts interact with the actin ..
  58. Glycan Biosynthesis in Cryptococcus neoformans
    Tamara L Doering; Fiscal Year: 2010
    ..and mutated a novel xylosyltransferase (Cxt1p), and showed that it acts in synthesis of GXM, GXMGal, and glycolipids;we also discovered a related enzyme (Cxt2p)...
  59. GLIA AND GLYCOCONJUGATES IN THE NEOSTRIATUM
    Dennis Steindler; Fiscal Year: 1999
    ..Recently, glial and glycoconjugate (glycoproteins, glycolipids, and glycosaminoglycans) boundaries have been discovered during brain pattern formation, and these structures ..
  60. Structure and function of family 1 glycosyltransferases
    R Garavito; Fiscal Year: 2006
    ..units onto the target compounds to create a diverse set of macromolecules in plants, animals, and bacteria: glycolipids, lipopolysaccharides, the glycan structures in plants, glycoproteins, and glycosylated natural products of ..
  61. Xenograft-like rejection of tumors in a-gal glycolipids
    URI GALILI GALILI; Fiscal Year: 2010
    ..We will study this treatment in a unique mouse model that simulates the pertinent human immunological parameters. Success in the studies in the mouse model will enable us to apply this treatment to cancer patients. ..
  62. IMMUNOCHEMISTRY OF GONOCOCCAL LIPOPOLYSACCHARIDE
    JOHN GRIFFISS; Fiscal Year: 2003
    ..LOS are outer membrane glycolipids that have a glycose moiety that consists of proximal Basal Region and three short distal chains, termed alpha ..
  63. Analysis of Human NKT cell auto-antigens
    Jenny E Gumperz; Fiscal Year: 2013
    ..The antigens that control NKT cell activation are lipids and glycolipids presented by CD1d molecules...
  64. Role of NKT cells in airway hyperreactivity &tolerance
    Omid Akbari; Fiscal Year: 2011
    ..NKT cells through their limited TCR repertoire recognize glycolipids presented by CD Id...
  65. ACYCLIC DIASTEREOSELECTION: METHODOLOGY AND SYNTHESIS
    William R Roush; Fiscal Year: 2010
    ..II) Total Syntheses of Nigricanoside A. Nigricanoside is a potent, antimitotic glycolipids isolated from the green alga Avrainvillea nigricans, but the relative and absolute stereochemical of ..
  66. BIOSYNTHESIS OF HUMAN PLATELET GLYCOSPHINGOLIPIDS
    CHENG TEH WANG; Fiscal Year: 1980
    Platelet membranes contain neutral glycolipids and acidic glycolipids (gangliosides). These lipids are conceivably critical for platelet functions, e.g., adhesion, aggregation, and serontonin binding...
  67. ISOLATION OF OLIGOSACCHARIDES--SUGAR-BINDING PROTEINS
    David Smith; Fiscal Year: 1990
    ..work outlined in this proposal will be the structural difinition and determination of the relative amounts of glycolipids from SW1116 cells...
  68. GLYCOLIPIDS AND HEMOLYTIC UREMIC SYNDROME
    David Haslam; Fiscal Year: 2002
    ..In almost all cases, verotoxins (shiga-like toxins) released by enterohemorrhagic E. coli bind to glycolipids on the endothelial cells, are then routed to the endoplasmic reticulum, and thereby inactivate the 28S ..
  69. Glycolipid Trafficking of Cholera Toxin by Lipid Rafts
    David E Saslowsky; Fiscal Year: 2010
    The goal of this application is to understand how epithelial cells of the intestinal mucosa sort membrane glycolipids into the retrograde trafficking pathway from the plasma membrane (PM) to the endoplasmic reticulum (ER), a route ..
  70. Role of ER-Localized Chaperones in Toxin Pathogenesis
    David Haslam; Fiscal Year: 2006
    ..After binding to cell surface glycolipids, the toxin is internalized and trafficked in retrograde fashion to the Golgi and endoplasmic reticulum (ER)...