Genomes and Genes
Summary: Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)
Publications276 found, 100 shown here
- Activation of natural killer T cells by glycolipidsEmmanuel Tupin
La Jolla Institute for Allergy and Immunology, San Diego, California, USA
Methods Enzymol 417:185-201. 2006..1, a C-type lectin expressed by natural killer (NK) cells. NKT cells use their TCR to recognize glycolipids bound to or presented by CD1d...
- Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteriaYuki Kinjo
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
Nat Immunol 12:966-74. 2011..Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, ..
- MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulenceScott E Converse
Department of Microbiology and Immunology, G W Hooper Foundation, University of California, San Francisco 94143, USA
Proc Natl Acad Sci U S A 100:6121-6. 2003....
- Schistosoma mansoni worm glycolipids induce an inflammatory phenotype in human dendritic cells by cooperation of TLR4 and DC-SIGNCaroline M W van Stijn
VU University Medical Center, Van den Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Mol Immunol 47:1544-52. 2010..We show here that Schistosoma mansoni worm glycolipids induce DC activation as indicated by upregulation of the maturation markers CD80, CD86 and MHC-II, as well as ..
- Harnessing invariant NKT cells in vaccination strategiesVincenzo Cerundolo
Tumour Immunology Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DU, UK
Nat Rev Immunol 9:28-38. 2009..In addition, we describe structural and kinetic analyses that assist in the design of optimal iNKT-cell agonists that could be used in the clinical setting as vaccine adjuvants...
- Rhamnolipid surfactant production affects biofilm architecture in Pseudomonas aeruginosa PAO1Mary E Davey
Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
J Bacteriol 185:1027-36. 2003..We propose that the maintenance of biofilm architecture represents a previously unrecognized step in the development of these microbial communities...
- High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodelingPriscille Brodin
Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Seongbuk gu, Seoul, Korea
PLoS Pathog 6:e1001100. 2010..the mutants in Rv1503c and Rv1506c were perturbed in the biosynthesis of acyltrehalose-containing glycolipids. Our results suggest that such glycolipids indeed play a critical role in the early intracellular fate of the ..
- Small-molecule pheromones that control dauer development in Caenorhabditis elegansRebecca A Butcher
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, Massachusetts 02115, USA
Nat Chem Biol 3:420-2. 2007..The identification of dauer pheromone components 1 and 2 will facilitate the identification of target receptors and downstream signaling proteins...
- Mapping fucosylated epitopes on glycoproteins and glycolipids of Schistosoma mansoni cercariae, adult worms and eggsM L M Robijn
Department of Parasitology, Centre of Infectious Diseases, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
Parasitology 130:67-77. 2005..Lewis X was found both on glycolipids and glycoproteins, yet with completely different expression patterns during the life-cycle: on glycolipids, ..
- Location, synthesis and function of glycolipids and polyglycerolphosphate lipoteichoic acid in Gram-positive bacteria of the phylum FirmicutesNathalie T Reichmann
Section of Microbiology, Imperial College London, South Kensington Campus, London, UK
FEMS Microbiol Lett 319:97-105. 2011..Furthermore, we will reintroduce the idea that LTA remains in close proximity to the bacterial membrane for its function during bacterial growth rather than as a surface-exposed structure...
- A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune responseMichael B Reed
Tuberculosis Research Section, NIAID, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA
Nature 431:84-7. 2004..Furthermore, the overproduction of PGL by M. tuberculosis or the addition of purified PGL to monocyte-derived macrophages was found to inhibit the release of these pro-inflammatory mediators in a dose-dependent manner...
- Two-enzyme systems for glycolipid and polyglycerolphosphate lipoteichoic acid synthesis in Listeria monocytogenesAlexander J Webb
Department of Microbiology, Imperial College London, London, UK
Mol Microbiol 74:299-314. 2009..Inactivation of LtaS leads to severe growth and cell division defects, underscoring the pivotal role of LTA in this gram-positive pathogen...
- The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipidsS A Porcelli
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
Annu Rev Immunol 17:297-329. 1999..by CD1 has revealed the surprising finding that these are predominantly a variety of foreign lipids and glycolipids, including several found prominently in the cell walls and membranes of pathogenic mycobacteria...
- Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipidsYa Jen Chang
Genomics Research Center, Academia Sinica, Taipei 115, Taiwan
Proc Natl Acad Sci U S A 104:10299-304. 2007..In vitro, glycolipids containing an aromatic ring in their acyl tail or sphingosine tail were more effective than alpha-GalCer in ..
- Elevated globotriaosylsphingosine is a hallmark of Fabry diseaseJohannes M Aerts
Amsterdam Lysosome Center, Departments of Medical Biochemistry, Internal Medicine, and Paediatrics, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
Proc Natl Acad Sci U S A 105:2812-7. 2008..Our findings suggest that measurement of circulating globotriaosylsphingosine will be useful to monitor Fabry disease and may contribute to a better understanding of the disorder...
- A Staphylococcus aureus ypfP mutant with strongly reduced lipoteichoic acid (LTA) content: LTA governs bacterial surface properties and autolysin activityIris Fedtke
Cellular and Molecular Microbiology Division, University of Tubingen, Department of Medical Microbiology and Hygiene, 72076 Tubingen, Germany
Mol Microbiol 65:1078-91. 2007..We propose to consider LTA and its biosynthetic enzymes as targets for new antibiofilm strategies...
- Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirementsElse Marie Agger
Adjuvant Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
PLoS ONE 3:e3116. 2008..The development of new adjuvants capable of inducing highly complex immune responses with strong antigen-specific T-cell responses in addition to antibodies is therefore urgently needed...
- Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivityYa Jen Chang
Division of Immunology and Allergy, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 121:57-69. 2011..These findings suggest what we believe to be a novel pathway that can regulate AHR, and a new therapeutic strategy (treatment with glycolipid activators of this NKT cell population) for asthma...
- Rhamnolipids modulate swarming motility patterns of Pseudomonas aeruginosaNicky C Caiazza
Department of Microbiology and Immunology, Rm 505, Vail Building, Dartmouth Medical School, Hanover, NH 03755, USA
J Bacteriol 187:7351-61. 2005..The abilities to produce and respond to rhamnolipids in the context of group behavior are discussed...
- Prospective study of serological conversion as a risk factor for development of leprosy among household contactsJ T Douglas
Department of Microbiology, University of Hawaii, Honolulu, HI 96822, USA
Clin Diagn Lab Immunol 11:897-900. 2004..Seropositive household contacts had a significantly higher risk of developing leprosy (relative hazard adjusted for age and sex [aRH], 7.2), notably multibacillary leprosy (aRH = 24), than seronegative contacts...
- Glyco- and sphingophosphonolipids from the medusa Phyllorhiza punctata: NMR and ESI-MS/MS fingerprintsLauro M de Souza
Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Parana, CP 19046, CEP 81531 990, Curitiba, PR, Brazil
Chem Phys Lipids 145:85-96. 2007..Two different groups of glycolipids and a sphingolipid were isolated by silica-gel column chromatography and characterized using GC-MS, ESI-MS, 1D, ..
- Lipids of pathogenic Mycobacteria: contributions to virulence and host immune suppressionL Guenin-Macé
Institut Pasteur, Unité Postulante Pathogénomique Mycobactérienne Intégrée, Paris, France
Transbound Emerg Dis 56:255-68. 2009..Here, the chemical structure, host cell receptors and biological actions of this emerging class of mycobacterial virulence factors are reviewed...
- Synthesis of a versatile building block for the preparation of 6-N-derivatized α-galactosyl ceramides: rapid access to biologically active glycolipidsPeter J Jervis
School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
J Org Chem 76:320-3. 2011..Biologically active glycolipids 6 and 8 have been synthesized to illustrate the applicability of the approach.
- MmpS4 promotes glycopeptidolipids biosynthesis and export in Mycobacterium smegmatisCaroline Deshayes
INSERM UMR 570, Unité de Pathogénie des Infections Systémiques, Paris Cedex 15, F 75730, France
Mol Microbiol 78:989-1003. 2010..MmpS4 in Mycobacterium smegmatis is required for the production and export of large amounts of cell surface glycolipids, but is dispensable for biosynthesis per se...
- The phenolic glycolipid of Mycobacterium tuberculosis differentially modulates the early host cytokine response but does not in itself confer hypervirulenceDaniel Sinsimer
Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute Center, University of Medicine and Dentistry of New Jersey, 225 Warren St, Newark, NJ 07103, USA
Infect Immun 76:3027-36. 2008..tuberculosis, it probably acts in concert with other bacterial factors which seem to be dependent on the background of the strain...
- Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxinsTetsuya Okuda
Department of Biochemistry II, Nagoya University School of Medicine, Tsurumai, Showa Ku, Nagoya 466 0065, Japan
J Biol Chem 281:10230-5. 2006..The lethal kinetics were similar regardless of lipopolysaccharide elimination in VT preparation, suggesting that basal Gb3/CD77 levels are sufficient for lethal effects of VTs...
- Novel interactions of glycosaminoglycans and bacterial glycolipids mediate binding of enterococci to human cellsIrina G Sava
Division of Infectious Diseases, University Medical Center Freiburg, 79106 Freiburg, Germany
J Biol Chem 284:18194-201. 2009....
- Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acidKelly S Doran
Department of Pediatrics, Division of Infectious Diseases, UCSD School of Medicine, La Jolla, California 92093, USA
J Clin Invest 115:2499-507. 2005..Our data suggest that LTA expression on the GBS surface plays a role in bacterial interaction with BBB endothelium and the pathogenesis of neonatal meningitis...
- A molecular mechanism that stabilizes cooperative secretions in Pseudomonas aeruginosaJoao B Xavier
Center for Systems Biology, Harvard University, 52 Oxford St, Cambridge, MA 02138, USA
Mol Microbiol 79:166-79. 2011..More generally, prudent regulation is a mechanism to stabilize cooperation...
- Mycobacterium tuberculosis cell wall glycolipids directly inhibit CD4+ T-cell activation by interfering with proximal T-cell-receptor signalingRobert N Mahon
Division of Infectious Diseases, Department of Medicine, Case Western Reserve University and University Hospitals, Case Medical Center, 10900 Euclid Avenue, BRB 1010B, Cleveland, OH 44106 4984, USA
Infect Immun 77:4574-83. 2009..tuberculosis. Fractionation identified that M. tuberculosis cell wall glycolipids, specifically, phosphatidylinositol mannoside and mannose-capped lipoarabinomannan, were potent inhibitors...
- Two types of MGDG synthase genes, found widely in both 16:3 and 18:3 plants, differentially mediate galactolipid syntheses in photosynthetic and nonphotosynthetic tissues in Arabidopsis thalianaK Awai
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama, Kanagawa 226 8501, Japan
Proc Natl Acad Sci U S A 98:10960-5. 2001..e., in inflorescence (atMGD2) and roots (atMGD3), where they conceivably influence the eukaryotic structure prominence in MGDG. In addition, their expression of type B enzymes is enhanced under phosphate deprivation...
- The mycobacterial glycopeptidolipids: structure, function, and their role in pathogenesisJeffrey S Schorey
Department of Biological Sciences, Eck Institute for Global Health and Infectious Diseases, University of Notre Dame, Notre Dame, IN 46556, USA
Glycobiology 18:832-41. 2008Glycopeptidolipids (GPLs) are a class of glycolipids produced by several nontuberculosis-causing members of the Mycobacterium genus including pathogenic and nonpathogenic species...
- Saccharomyces cerevisiae-based molecular tool kit for manipulation of genes from gram-negative bacteriaRobert M Q Shanks
Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
Appl Environ Microbiol 72:5027-36. 2006..These tools can be used for genetic studies of pseudomonads and many other gram-negative bacteria...
- Activation of invariant natural killer T cells by synthetic glycolipid ligands suppresses autoantibody-induced arthritisShinjiro Kaieda
National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Arthritis Rheum 56:1836-45. 2007..This study was designed to evaluate the protective effects of SGL-S23 in an effector phase of arthritis...
- Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytesN Burdin
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
J Immunol 161:3271-81. 1998Mouse CD1 (mCD1) glycoproteins are known to present peptides, while human CD1 molecules present glycolipids. In mice, mCD1-autoreactive NK T cells play critical roles in various immune responses, through the secretion of high amounts of ..
- Glycolipids are involved in biofilm accumulation and prolonged bacteraemia in Enterococcus faecalisChristian Theilacker
Division of Infectious Diseases, Department of Medicine, University Medical Center Freiburg, Germany
Mol Microbiol 71:1055-69. 2009..In several Gram-positive bacteria, membrane glycolipids have been implicated in biofilm formation...
- Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosaU A Ochsner
Institute for Biotechnology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich
J Bacteriol 176:2044-54. 1994..Additionally, such PG201::'rhlR' mutant strains lacked elastase activity, indicating that the RhlR protein is a pleiotropic regulator...
- Rhamnolipids: diversity of structures, microbial origins and rolesAhmad Mohammad Abdel-Mawgoud
INRS Institut Armand Frappier, 531 Boulevard des Prairies, Laval, QC, H7V 1B7, Canada
Appl Microbiol Biotechnol 86:1323-36. 2010....
- DC-SIGN mediates binding of dendritic cells to authentic pseudo-LewisY glycolipids of Schistosoma mansoni cercariae, the first parasite-specific ligand of DC-SIGNSandra Meyer
Institute of Biochemistry, Medical Faculty, Justus Liebig University Giessen, Germany
J Biol Chem 280:37349-59. 2005..Here we report that the CLR DC-SIGN mediates adhesion of DCs to authentic glycolipids derived from Schistosoma mansoni cercariae and their excretory/secretory products...
- Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophiliaMarie Laure Michel
Unité Mixte de Recherche 8147, Centre National de la Recherche Scientifique, Faculté de Médecine René Descartes, Paris V, Hopital Necker, Paris, Cedex 15, France
J Exp Med 204:995-1001. 2007..upon synthetic (alpha-galactosylceramide [alpha-GalCer] or PBS-57), as well as natural (lipopolysaccharides or glycolipids derived from Sphingomonas wittichii and Borrelia burgdorferi), ligand stimulation. NK1...
- Globotriaosylsphingosine actions on human glomerular podocytes: implications for Fabry nephropathyMaria D Sanchez-Niño
Nefrologia, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid and Instituto Reina Sofia de Investigaciones Nefrológicas IRSIN, Madrid, Spain
Nephrol Dial Transplant 26:1797-802. 2011....
- Glycosidase-induced fusion of isoprenoid gentiobiosyl lipid membranes at acidic pHG Dennis Sprott
Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Ottawa, ON K1A OR6, Canada
Glycobiology 19:267-76. 2009..Radiotracer and (1)H NMR studies revealed that glycolipids in fused archaeosomes were not degraded significantly by glucosidase treatment during fusion...
- The fidelity, occasional promiscuity, and versatility of T cell receptor recognitionDale I Godfrey
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
Immunity 28:304-14. 2008..Collectively, these studies have revealed the versatility of the TCR in recognizing the distinct yet evolutionarily related proteinaceous and lipid-presenting molecules of the immune system...
- A subset of human pancreatic beta cells express functional CD14 receptors: a signaling pathway for beta cell-related glycolipids, sulfatide and β-galactosylceramideThomas Osterbye
Bartholin Instituttet, Rigshospitalet, Biocenter Copenhagen, Copenhagen N, Denmark
Diabetes Metab Res Rev 26:656-67. 2010..Multiple factors may contribute to the development of T1DM. Among these, the metabolic state of beta-cells and pro-inflammatory cytokines, produced by infiltrating immune cells, have been implicated in the precipitation of T1DM...
- Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a beta-linked self-glycolipidPhilomena Arrenberg
Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
Proc Natl Acad Sci U S A 107:10984-9. 2010TCR-mediated recognition of beta-linked self-glycolipids bound to CD1d is poorly understood...
- Fatty acyl structures of mycobacterium tuberculosis sulfoglycolipid govern T cell responseJulie Guiard
Département Mécanismes Moléculaires des Infections Mycobactériennes, Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
J Immunol 182:7030-7. 2009..These studies have major implications for the design of sulfoglycolipid analogs with potential use as tuberculosis subunit vaccines...
- Mutational analysis of cell wall biosynthesis in Mycobacterium aviumJean Pierre Laurent
Seattle Biomedical Research Institute, Seattle, Washington 98109, USA
J Bacteriol 185:5003-6. 2003..Nineteen such mutants were isolated and mapped, including 10 with insertions in a functional island of cell wall biosynthetic genes that spans approximately 40 kb of the M. avium genome...
- Comparative metabolomics reveals biogenesis of ascarosides, a modular library of small-molecule signals in C. elegansStephan H von Reuss
Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
J Am Chem Soc 134:1817-24. 2012..Our screen further demonstrates that ascaroside biosynthesis is directly affected by nutritional status and that excretion of the final products is highly selective...
- Anionic lipids are required for chloroplast structure and function in ArabidopsisBin Yu
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 1319, USA
Plant J 36:762-70. 2003Photosynthetic membranes of plants primarily contain non-phosphorous glycolipids. The exception is phosphatidylglycerol (PG), which is an acidic/anionic phospholipid...
- The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody productionMalou Henriksen-Lacey
School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK
J Control Release 154:131-7. 2011....
- Immune responses induced by spirochetal outer membrane lipoproteins and glycolipidsNicolas W J Schröder
Department for Dermatology and Allergology, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
Immunobiology 213:329-40. 2008..However, there is increasing evidence that next to lipoproteins, glycolipids may also play an important role in responses of the immune system towards spirochetes...
- Methylation of GPLs in Mycobacterium smegmatis and Mycobacterium aviumDharshini Jeevarajah
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
J Bacteriol 186:6792-9. 2004..The GPLs are glycolipids that contain modified sugars including acetylated 6-deoxy-talose and methylated rhamnose...
- How cholesterol constrains glycolipid conformation for optimal recognition of Alzheimer's beta amyloid peptide (Abeta1-40)Nouara Yahi
Université Paul Cézanne Aix Marseille 3, université de la Méditerranée Aix Marseille 2, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, CNRS UMR 6231, INRA USC 2027, Interactions Moléculaires et Systèmes Membranaires, Faculté des Sciences Saint Jérôme, Marseille, France
PLoS ONE 5:e9079. 2010..These data shed some light on the complex molecular interplay between cell surface GSLs, cholesterol and Abeta peptides, and on the influence of this molecular ballet on Abeta-membrane interactions...
- Increase in rhamnolipid synthesis under iron-limiting conditions influences surface motility and biofilm formation in Pseudomonas aeruginosaRivka Glick
The Bacterial Biofilm Research Laboratory, The Institute for Nanotechnology and Advanced Materials, The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
J Bacteriol 192:2973-80. 2010..These results highlight the importance of biosurfactant production in determining the mature structure of P. aeruginosa biofilms under iron-limiting conditions...
- Structure and function of glycoglycerolipids in plants and bacteriaGeorg Hölzl
Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
Prog Lipid Res 46:225-43. 2007....
- A glycosyltransferase involved in biosynthesis of triglycosylated glycopeptidolipids in Mycobacterium smegmatis: impact on surface propertiesCaroline Deshayes
INSERM UMR570, Faculte de Medecine Necker Enfants Malades, 156 rue de Vaugirard, Paris Cedex 15, F 75730, France
J Bacteriol 187:7283-91. 2005..Glycopeptidolipids (GPLs) are species- or type species-specific glycolipids that are present at the surface of a number of mycobacteria and that are characterized by a high variability in ..
- Testis-specific sulfoglycolipid, seminolipid, is essential for germ cell function in spermatogenesisYanlong Zhang
Department of Molecular Genetics, Kochi University Medical School, Kochi 783 8505, Japan
Glycobiology 15:649-54. 2005....
- Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconiaRoger G Linington
Department of Chemistry, University of British Columbia, Vancouver, B C V6T 1Z1, Canada
J Nat Prod 69:173-7. 2006..fractionation of the crude extract led to the isolation of caminosides A (1) to D (4), a family of antimicrobial glycolipids. The structures of the three new caminosides B (2) to D (4) have been elucidated by spectroscopic analysis.
- Stem cell glycolipidsMakoto Yanagisawa
Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street CA4040, Augusta, GA 30912, USA
Neurochem Res 36:1623-35. 2011b>Glycolipids are compounds containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety...
- The impact of the absence of glycopeptidolipids on the ultrastructure, cell surface and cell wall properties, and phagocytosis of Mycobacterium smegmatisGilles Etienne
Institut de Pharmacologie et de Biologie Structurale, Unité Mixte de Recherche du Centre de National de Recherche Scientifique et de l Université Paul Sabatier UMR 5089, 205 route de Narbonne, 31077 Toulouse Cedex 04, France
Microbiology 148:3089-100. 2002..smegmatis. Altogether, these data showed that, in addition to being distinctive markers of numerous mycobacterial species, GPLs play a role in the bacterial phenotype, surface properties and cell wall permeability...
- Acylated cholesteryl galactoside as a novel immunogenic motif in Borrelia burgdorferi sensu strictoNicolas W J Schröder
Institut für Mikrobiologie und Hygiene, Universitatsklinikum Charite, Medizinische Fakultat der Humboldt Universitat zu Berlin, Dorotheenstrasse 96, D 10117 Berlin, Germany
J Biol Chem 278:33645-53. 2003..Here we report on a novel class of immunogenic glycolipids purified from B. burgdorferi sensu stricto B31...
- Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilliLiana Tsenova
Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute, Newark, New Jersey 07103, USA
J Infect Dis 192:98-106. 2005....
- Rhamnolipid biosurfactants decrease the toxicity of chlorinated phenols to Pseudomonas putida DOT-T1EL Chrzanowski
Department of Organic Chemistry, Institute of Chemical Technology and Engineering, Poznan University of Technology, Poznan, Poland
Lett Appl Microbiol 48:756-62. 2009..To investigate the effect of a mixture of rhamnolipid R1 and R2 biosurfactants produced by a Pseudomonas aeruginosa strain on the toxicity of phenol and chlorophenols to Pseudomonas putida DOT-T1E...
- Effect of monorhamnolipid on the degradation of n-hexadecane by Candida tropicalis and the association with cell surface propertiesGuangming Zeng
College of Environmental Science and Engineering, Hunan University, Changsha 410082, People s Republic of China
Appl Microbiol Biotechnol 90:1155-61. 2011..The changes of cell surface properties may be a reason for the enhanced biodegradation of hexadecane by the yeast. The results indicate the potential application of monoRL in the bioremediation of hydrocarbons...
- Sulfolipids and glycolipid sulfotransferase activities in human renal cell carcinoma cellsT Kobayashi
Biochemistry Laboratory, Hokkaido University School of Medicine, Sapporo, Japan
Br J Cancer 67:76-80. 1993..1989. Cancer Res., 49, 335-339) is due to the elevation of the sulfotransferase activities of renal carcinoma cells themselves...
- Fine tuning by human CD1e of lipid-specific immune responsesFederica Facciotti
Experimental Immunology, Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland
Proc Natl Acad Sci U S A 108:14228-33. 2011..It binds lipids in lysosomes and facilitates processing of complex glycolipids, thus promoting editing of lipid antigens...
- A blend of small molecules regulates both mating and development in Caenorhabditis elegansJagan Srinivasan
Howard Hughes Medical Institute and Biology Division, California Institute of Technology, 1200 E California Boulevard, Pasadena, California 91125, USA
Nature 454:1115-8. 2008..The ascaroside signalling system thus connects reproductive and developmental pathways and represents a unique example of structure- and concentration-dependent differential activity of signalling molecules...
- Insecticidal activity of rhamnolipid isolated from pseudomonas sp. EP-3 against green peach aphid (Myzus persicae)Seul Ki Kim
Department of Agricultural Chemistry and Biology, Institute of Agricultural Science and Technology
J Agric Food Chem 59:934-8. 2011..This is the first report of rhamnolipid as an insecticidal metabolite against M. persicae. Rhamnolipid shows potential for use as a pesticide to control agricultural pests...
- Deciphering sulfoglycolipids of Mycobacterium tuberculosisEmilie Layre
CNRS IPBS Institut de Pharmacologie et de Biologie Structurale 205 route de Narbonne, F 31077, Toulouse, France
J Lipid Res 52:1098-110. 2011..Our results further confirm the requirement of MmpL8 for the complete assembly of the tetra-acylated forms of SGL and also provide, by the discovery of new intermediates, insights in terms of the possible SGL biosynthetic pathways...
- Reduction of elevated plasma globotriaosylsphingosine in patients with classic Fabry disease following enzyme replacement therapyMarielle J van Breemen
Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands
Biochim Biophys Acta 1812:70-6. 2011..Our investigation revealed that ERT of Fabry patients reduces plasma lysoGb3, regardless of the recombinant enzyme used. This finding shows that ERT can correct a characteristic biochemical abnormality in Fabry patients...
- Archaeosome vaccine adjuvants induce strong humoral, cell-mediated, and memory responses: comparison to conventional liposomes and alumL Krishnan
Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada K1A 0R6
Infect Immun 68:54-63. 2000..Thus, archaeosomes may be potent vaccine carriers capable of facilitating strong primary and memory humoral, and cell-mediated immune responses to the entrapped antigen...
- Lipopentapeptide induces a strong host humoral response and distinguishes Mycobacterium avium subsp. paratuberculosis from M. avium subsp. aviumFranck Biet
UR1282, Infectiologie Animale, Santé Publique, INRA Centre de Tours, F 37380 Nouzilly, France
Vaccine 26:257-68. 2008..avium subsp. paratuberculosis (Map), the etiologic agent of Johne's disease in cattle, and several conflicting data have been produced...
- The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cellsShinji Oki
Department of Immunology, National Institute of Neuroscience, National Center for Neuroscience and Psychiatry, Tokyo, Japan
J Clin Invest 113:1631-40. 2004..and that the length of the sphingosine chain determines the duration of NKT cell stimulation by CD1d-associated glycolipids. Furthermore, IFN-gamma production by NKT cells requires longer T cell receptor stimulation than is required ..
- Production of rhamnolipids by Pseudomonas aeruginosaGloria Soberón-Chávez
Departamento de Bioprocesos y Biocatálisis, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
Appl Microbiol Biotechnol 68:718-25. 2005..We also discuss the factors controlling the production of rhamnolipids and the proposed roles this biosurfactant plays in P. aeruginosa lifestyle...
- A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cellsKwok S Wun
The Protein Crystallography Unit, ARC Centre of Excellence in Structural and Functional Microbial Genomics, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
Immunity 34:327-39. 2011..Accordingly, we have provided a molecular basis for understanding how modifications in AGLs can result in striking alterations in the cellular response of NKT cells...
- Timing and localization of rhamnolipid synthesis gene expression in Pseudomonas aeruginosa biofilmsYannick Lequette
Department of Microbiology, 540 EMRB, Roy and Lucille Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
J Bacteriol 187:37-44. 2005..The differential expression of rhlAB may play a role in the development of normal biofilm architecture...
- Quorum sensing-dependent virulence during Pseudomonas aeruginosa colonisation and pneumonia in mechanically ventilated patientsThilo Köhler
Service of Infectious Diseases, University Hospital Geneva, 4 rue Gabrielle Perret Gentil, Geneva 14, Switzerland
Thorax 65:703-10. 2010..The role of quorum sensing (QS), regulating virulence in this pathogen, during colonisation and development of VAP is unknown...
- RhlA converts beta-hydroxyacyl-acyl carrier protein intermediates in fatty acid synthesis to the beta-hydroxydecanoyl-beta-hydroxydecanoate component of rhamnolipids in Pseudomonas aeruginosaKun Zhu
Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
J Bacteriol 190:3147-54. 2008..We conclude that RhlA is necessary and sufficient to form the acyl moiety of RL and that the flux of carbon through FASII accelerates to support RL production and maintain a supply of acyl chains for phospholipid synthesis...
- Pseudomonas aeruginosa virulence analyzed in a Dictyostelium discoideum host systemPierre Cosson
Département de Morphologie, Universite de Geneve, Centre Medical Universitaire, CH 1211 Geneva 4, Switzerland
J Bacteriol 184:3027-33. 2002..aeruginosa should show reduced virulence. This result was confirmed in a rat model of acute pneumonia. Thus, D. discoideum could be used as a simple nonmammalian host system to assess pathogenicity of P. aeruginosa...
- Axo-glial interactions regulate the localization of axonal paranodal proteinsJ L Dupree
Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Cell Biol 147:1145-52. 1999....
- Self-produced extracellular stimuli modulate the Pseudomonas aeruginosa swarming motility behaviourJulien Tremblay
INRS Institut Armand Frappier, Laval Quebec, H7V 1B7, Canada
Environ Microbiol 9:2622-30. 2007..We propose a model explaining how HAAs and di-RLs together modulate the behaviour of swarming migrating cells by acting as self-produced negative and positive chemotactic-like stimuli...
- Synthetic glycolipid OCH prevents insulitis and diabetes in NOD miceMiho Mizuno
Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
J Autoimmun 23:293-300. 2004....
- Mycobacteria use their surface-exposed glycolipids to infect human macrophages through a receptor-dependent processChristelle Villeneuve
Département Mécanismes Moléculaires des Infections Mycobactériennes, Institut de Pharmacologie et Biologie Structurale, Unité Mixte de Recherche 5089 Centre National de la Recherche Scientifique, Universite Paul Sabatier, 31077 Toulouse, France
J Lipid Res 46:475-83. 2005..GPL III, but not PIM2, also directed particle entry through the mannose receptor. Therefore, surface-exposed mycobacterial PIM and polar GPL participate in the receptor-dependent internalization of mycobacteria in human macrophages...
- Trypanosomatid and fungal glycolipids and sphingolipids as infectivity factors and potential targets for development of new therapeutic strategiesErika Suzuki
Division of Glycoconjugate Immunochemistry, Department of Biochemistry, Ed J L Prado, Rua Botucatu, 862, 04023 900, Sao Paulo, SP, Brazil
Biochim Biophys Acta 1780:362-9. 2008..Other pathogens, such as fungi, also present unique glycolipids which may have an important role for the fungal development and/or disease establishment...
- Preferential T(h)2 polarization by OCH is supported by incompetent NKT cell induction of CD40L and following production of inflammatory cytokines by bystander cells in vivoShinji Oki
Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
Int Immunol 17:1619-29. 2005..In addition, highlighted in this study is the characteristic property of OCH that can induce the differential production of IFN-gamma or IL-4 according to the availability of IL-12...
- Lipid and glycolipid antigens of CD1d-restricted natural killer T cellsManjunatha M Venkataswamy
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Semin Immunol 22:68-78. 2010..antigens provide an increasingly detailed picture of how the specific structural features of these lipids and glycolipids influence their ability to be presented to NKT cells and stimulate their diverse immunologic functions...
- Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosaPeter Ø Jensen
Department of Clinical Microbiology, Rigshospitalet, DK 2100 Copenhagen Ø, Denmark
Microbiology 153:1329-38. 2007..aeruginosa by disabling the PMNs, which are a major first line of defence of the host. Furthermore, the study emphasizes the inhibition of QS as a target for the treatment of infections with P. aeruginosa...
- Mycobacterium leprae infection in monocyte-derived dendritic cells and its influence on antigen-presenting functionKen Hashimoto
Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
Infect Immun 70:5167-76. 2002..M. leprae is a unique pathogen which remains resistant to DC-mediated T-cell immunity, at least in the early stages of infection...
- Effects of additives on the structure of rhamnolipid (biosurfactant): a small-angle neutron scattering (SANS) studyBehnaz Dahrazma
Department of Environmental Geology Faculty of Earth Science, Shahrood University of Technology, Shahrood 316 3619995161, Iran
J Colloid Interface Sci 319:590-3. 2008..The size of the aggregates in both acidic and basic condition is fine enough to ease the flow of the rhamnolipid solution through the porous media with the pore sizes as small as 200 nm...
- Glycolipids from the formosan soft coral Lobophytum crassumChih Hua Chao
Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan ROC
Chem Pharm Bull (Tokyo) 55:1720-3. 2007Three glycolipids (1--3), possessing a sugar moiety at C-2 of glycerol ether, have been isolated from the Formosan soft coral Lobophytum crassum...
- Neutral glycolipids of the filamentous fungus Neurospora crassa: altered expression in plant defensin-resistant mutantsChaeho Park
Complex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602 7229, USA
J Lipid Res 46:759-68. 2005..The potential implications of these findings with respect to defensin resistance in the N. crassa mutants are discussed...
- Glycolipids as immunostimulating agentsDouglass Wu
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Bioorg Med Chem 16:1073-83. 2008..A combination of structure-activity relationship (SAR), crystallographic studies, and discovery of new 'natural' antigens has led to greater understanding of the structural requirements for optimal natural killer T-cell activation...
- A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other componentsRebecca A Butcher
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:14288-92. 2008....
- Murine glycosyltransferases responsible for the expression of globo-series glycolipids: cDNA structures, mRNA expression, and distribution of their productsYuko Fujii
Department of Clinical Immunology, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
Glycobiology 15:1257-67. 2005..In this study, murine cDNAs of two glycosyltransferases responsible for the synthesis of globo-series glycolipids and mRNA expression of those genes were analyzed. Distribution of their products was also analyzed...
- One-pot syntheses of immunostimulatory glycolipidsMatthew Schombs
Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
J Org Chem 75:4891-8. 2010b>Glycolipids containing alpha-linked galactosyl and glucosyl moieties have been shown to possess unique immunostimulatory activity creating a need for access to diverse and anomerically pure sources of these compounds for immunological ..
- Characteristic expression of Lewis-antigenic glycolipids in human ovarian carcinoma-derived cells with anticancer drug-resistanceMasao Iwamori
Department of Biochemistry, Faculty of Science and Technology, Kinki University, 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
J Biochem 141:309-17. 2007..In addition to the transporters expression, the amounts of glycolipids, particularly their longer carbohydrate structures, in the resistant cells increased to 3-4-fold of those in ..
- Inhibitory effect on replicative DNA polymerases, human cancer cell proliferation, and in vivo anti-tumor activity by glycolipids from spinachNaoki Maeda
Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, 518 Arise, Ikawadanicho, Nishi ku, Kobe, Hyogo 651 2180, Japan
Curr Med Chem 14:955-67. 2007We succeeded in purifying a major glycolipids fraction (i.e...
- Membrane glycolipids in stem cellsRobert K Yu
Institute of Molecular Medicine and Genetics and Institute of Neuroscience, Medical College of Georgia, Augusta, GA 30912, USA
FEBS Lett 584:1694-9. 2010..Recently, studies regarding the biological functions of glycolipids and cell surface microdomains (caveolae, lipid rafts, or glycolipid-enriched microdomains) in stem cells are ..
- Critical role of amino acid position 343 of surfactant protein-D in the selective binding of glycolipids from Mycobacterium tuberculosisTracy K Carlson
Division of Infectious Diseases, Department of Internal Medicine, Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
Glycobiology 19:1473-84. 2009..We conclude that the 343 position is critical in defining the binding pattern of SP-D proteins to M.tb and its mannosylated cell envelope components...
- Multiple roles of biosurfactants in structural biofilm development by Pseudomonas aeruginosaSünje Johanna Pamp
Centre for BioScience Technology, BioCentrum DTU, Building 301, The Technical University of Denmark, DK 2800 Lyngby, Denmark
J Bacteriol 189:2531-9. 2007..aeruginosa biofilms demonstrated that the wild-type and rhlA and pilA mutant strains formed distinct subpopulations on top of each other dependent on their ability to migrate and produce biosurfactants...
- MALDI-TOF mass spectrometry of naturally occurring mixtures of monorhamnolipids and dirhamnolipidsNeil P J Price
Bioproducts and Biocatalysis, USDA ARS NCAUR, 1815 North University Street, Peoria, IL 61604, USA
Carbohydr Res 344:204-9. 2009..MALDI-TOFMS analysis allows the rapid screening of variously acylated rhamnolipids, and has potential for selective identification of new surfactants from microbial strains...
- NKT Cells Immunotherapy: Targeting Dendritic Cells with Glycolipid LiposomesPeng Wang; Fiscal Year: 2007..In contrast, a specialized subpopulation of T cells called NKT cells recognize glycolipids antigens presented by the MHC class l-like molecule; CD1d...
- The Role of Glycolipids and CD1 in the Immunology of Leishmania InfectionLaurence U Buxbaum; Fiscal Year: 2010..NKT cells are activated by an unusual protein called CD1, which is involved in immune responses provoked by glycolipids (like GIPLs). The way in which CD1 and NKT cells work in infection is not well understood...
- Biogenesis of lipoarabinomannan in mycobacteriaMary Jackson; Fiscal Year: 2010..PIM) and their multiglycosylated counterparts, lipomannan (LM) and lipoarabinomannan (LAM) are complex glycolipids and lipoglycans found in the envelopes of all mycobacterial species...
- LIPID A MODIFICATION SYSTEMS IN GRAM-NEGATIVE BACTERIACHRISTIAN RAETZ; Fiscal Year: 2007Lipopolysaccharides (LPSs) are remarkable glycolipids that comprise the outer surfaces of Gram-negative bacteria, including the symbiotic organism, Rhizobium leguminosamm...
- BIOSYNTHESIS AND REGULATION OF SUBSTITUTED SIALIC ACIDSAjit Varki; Fiscal Year: 1990Sialic acids, which are the outermost sugars on the glycoproteins and glycolipids of mammalian cells, can be substituted at the 4,7,8, and 9 positions with O-acetyl esters (or other less common substitutions) in a tissue-specific fashion...
- Role of Nuclear Gangliosides in Neuronal FunctionRobert W Ledeen; Fiscal Year: 2010..plasma membrane, but a number of intracellular mechanisms are now known to be mediated and modulated by these glycolipids. Our work has shown GM1 in particular to have a critical role regulating Ca2+ homeostasis in the nucleus and ..
- Structure and function of family 1 glycosyltransferasesR Garavito; Fiscal Year: 2006..units onto the target compounds to create a diverse set of macromolecules in plants, animals, and bacteria: glycolipids, lipopolysaccharides, the glycan structures in plants, glycoproteins, and glycosylated natural products of ..
- Xenograft-like rejection of tumors in a-gal glycolipidsURI GALILI GALILI; Fiscal Year: 2010..We will study this treatment in a unique mouse model that simulates the pertinent human immunological parameters. Success in the studies in the mouse model will enable us to apply this treatment to cancer patients. ..
- IMMUNOCHEMISTRY OF GONOCOCCAL LIPOPOLYSACCHARIDEJOHN GRIFFISS; Fiscal Year: 2003..LOS are outer membrane glycolipids that have a glycose moiety that consists of proximal Basal Region and three short distal chains, termed alpha ..
- SORTING OF A LIPID-PROTEIN COMPLEX IN EPITHELIAL CELLSDeborah Brown; Fiscal Year: 1993..Membrane complexes that contain both glycolipids and GPI-anchored proteins have been isolated, using their surprising insolubility in non-ionic detergents...
- CD1 AND BCR/Fc RECEPTOR TARGETED LIGANDGrant Yeaman; Fiscal Year: 2001..Typically, CD1 molecules present lipids or glycolipids to T cells. CD1 ligands are associated with T cells specific for M. tuberculosis...
- SHORT- AND LONG-RANGE FORCES BETWEEN MEMBRANCE SURFACESTHOMAS MC INTOSH; Fiscal Year: 1993..In particular, these pressures will be measured for bilayers containing various glycolipids or containing lipids with covalently attached polyethylene glycol (PEG)...
- GLYCOSPHINGOLIPID METABOLISM AND MENTAL RETARDATIONGlyn Dawson; Fiscal Year: 2000The broad, long-term objectives are to understand the role of glycolipids (glycoshingolipids (GSL) and inositolphosphoglycerides) in normal nervous function and the pathogenic processes involving them which lead to mental retardation...
- Glycolipid Trafficking of Cholera Toxin by Lipid RaftsDavid Saslowsky; Fiscal Year: 2007The goal of this application is to understand how epithelial cells of the intestinal mucosa sort membrane glycolipids into the retrograde trafficking pathway from the plasma membrane (PM) to the endoplasmic reticulum (ER), a route ..
- GLYCOLIPIDS AND HEMOLYTIC UREMIC SYNDROMEDavid Haslam; Fiscal Year: 2002..In almost all cases, verotoxins (shiga-like toxins) released by enterohemorrhagic E. coli bind to glycolipids on the endothelial cells, are then routed to the endoplasmic reticulum, and thereby inactivate the 28S ..
- An Untested Approach: Biomarkers for Colon CancerKhushi Matta; Fiscal Year: 2007..is known that cancer is associated with alterations in the glycosylation patterns of glycoconjugates including glycolipids and glycoproteins...
- Role of ER-Localized Chaperones in Toxin PathogenesisDavid Haslam; Fiscal Year: 2006..After binding to cell surface glycolipids, the toxin is internalized and trafficked in retrograde fashion to the Golgi and endoplasmic reticulum (ER)...
- Naturally Occurring IgM Anti-Leucocyte Autoantibodies Protect Against Renal IRIMARK DOUGLAS OKUSA; Fiscal Year: 2010..Based on these findings we questioned whether IgM- ALA downregulate inflammation that accompanies renal IRI. Glycolipids released after ischemic injury are processed and presented by resident dendritic cells (DC), in presence of ..