glycolipids

Summary

Summary: Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)

Top Publications

  1. ncbi Activation of natural killer T cells by glycolipids
    Emmanuel Tupin
    La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    Methods Enzymol 417:185-201. 2006
  2. ncbi Two-enzyme systems for glycolipid and polyglycerolphosphate lipoteichoic acid synthesis in Listeria monocytogenes
    Alexander J Webb
    Department of Microbiology, Imperial College London, London, UK
    Mol Microbiol 74:299-314. 2009
  3. ncbi A Staphylococcus aureus ypfP mutant with strongly reduced lipoteichoic acid (LTA) content: LTA governs bacterial surface properties and autolysin activity
    Iris Fedtke
    Cellular and Molecular Microbiology Division, University of Tubingen, Department of Medical Microbiology and Hygiene, 72076 Tubingen, Germany
    Mol Microbiol 65:1078-91. 2007
  4. ncbi Rhamnolipids modulate swarming motility patterns of Pseudomonas aeruginosa
    Nicky C Caiazza
    Department of Microbiology and Immunology, Rm. 505, Vail Building, Dartmouth Medical School, Hanover, NH 03755, USA
    J Bacteriol 187:7351-61. 2005
  5. ncbi Novel interactions of glycosaminoglycans and bacterial glycolipids mediate binding of enterococci to human cells
    Irina G Sava
    Division of Infectious Diseases, University Medical Center Freiburg, 79106 Freiburg, Germany
    J Biol Chem 284:18194-201. 2009
  6. ncbi A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response
    Michael B Reed
    Tuberculosis Research Section, NIAID, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA
    Nature 431:84-7. 2004
  7. ncbi A molecular mechanism that stabilizes cooperative secretions in Pseudomonas aeruginosa
    Joao B Xavier
    Center for Systems Biology, Harvard University, 52 Oxford St, Cambridge, MA 02138, USA
    Mol Microbiol 79:166-79. 2011
  8. ncbi Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid
    Kelly S Doran
    Department of Pediatrics, Division of Infectious Diseases, UCSD School of Medicine, La Jolla, California 92093, USA
    J Clin Invest 115:2499-507. 2005
  9. ncbi Glycolipids are involved in biofilm accumulation and prolonged bacteraemia in Enterococcus faecalis
    Christian Theilacker
    Division of Infectious Diseases, Department of Medicine, University Medical Center Freiburg, Germany
    Mol Microbiol 71:1055-69. 2009
  10. ncbi The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids
    S A Porcelli
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Annu Rev Immunol 17:297-329. 1999

Research Grants

  1. NKT Cells Immunotherapy: Targeting Dendritic Cells with Glycolipid Liposomes
    Peng Wang; Fiscal Year: 2007
  2. The Role of Glycolipids and CD1 in the Immunology of Leishmania Infection
    Laurence U Buxbaum; Fiscal Year: 2010
  3. Biogenesis of lipoarabinomannan in mycobacteria
    Mary Jackson; Fiscal Year: 2010
  4. LIPID A MODIFICATION SYSTEMS IN GRAM-NEGATIVE BACTERIA
    CHRISTIAN RAETZ; Fiscal Year: 2007
  5. BIOSYNTHESIS AND REGULATION OF SUBSTITUTED SIALIC ACIDS
    Ajit Varki; Fiscal Year: 1990
  6. Role of Nuclear Gangliosides in Neuronal Function
    Robert W Ledeen; Fiscal Year: 2010
  7. Structure and function of family 1 glycosyltransferases
    R Garavito; Fiscal Year: 2006
  8. Xenograft-like rejection of tumors in a-gal glycolipids
    URI GALILI GALILI; Fiscal Year: 2010
  9. IMMUNOCHEMISTRY OF GONOCOCCAL LIPOPOLYSACCHARIDE
    JOHN GRIFFISS; Fiscal Year: 2003
  10. SORTING OF A LIPID-PROTEIN COMPLEX IN EPITHELIAL CELLS
    Deborah Brown; Fiscal Year: 1993

Detail Information

Publications225 found, 100 shown here

  1. ncbi Activation of natural killer T cells by glycolipids
    Emmanuel Tupin
    La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    Methods Enzymol 417:185-201. 2006
    ..1, a C-type lectin expressed by natural killer (NK) cells. NKT cells use their TCR to recognize glycolipids bound to or presented by CD1d...
  2. ncbi Two-enzyme systems for glycolipid and polyglycerolphosphate lipoteichoic acid synthesis in Listeria monocytogenes
    Alexander J Webb
    Department of Microbiology, Imperial College London, London, UK
    Mol Microbiol 74:299-314. 2009
    ..Inactivation of LtaS leads to severe growth and cell division defects, underscoring the pivotal role of LTA in this gram-positive pathogen...
  3. ncbi A Staphylococcus aureus ypfP mutant with strongly reduced lipoteichoic acid (LTA) content: LTA governs bacterial surface properties and autolysin activity
    Iris Fedtke
    Cellular and Molecular Microbiology Division, University of Tubingen, Department of Medical Microbiology and Hygiene, 72076 Tubingen, Germany
    Mol Microbiol 65:1078-91. 2007
    ..We propose to consider LTA and its biosynthetic enzymes as targets for new antibiofilm strategies...
  4. ncbi Rhamnolipids modulate swarming motility patterns of Pseudomonas aeruginosa
    Nicky C Caiazza
    Department of Microbiology and Immunology, Rm. 505, Vail Building, Dartmouth Medical School, Hanover, NH 03755, USA
    J Bacteriol 187:7351-61. 2005
    ..The abilities to produce and respond to rhamnolipids in the context of group behavior are discussed...
  5. ncbi Novel interactions of glycosaminoglycans and bacterial glycolipids mediate binding of enterococci to human cells
    Irina G Sava
    Division of Infectious Diseases, University Medical Center Freiburg, 79106 Freiburg, Germany
    J Biol Chem 284:18194-201. 2009
    ....
  6. ncbi A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response
    Michael B Reed
    Tuberculosis Research Section, NIAID, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA
    Nature 431:84-7. 2004
    ..Furthermore, the overproduction of PGL by M. tuberculosis or the addition of purified PGL to monocyte-derived macrophages was found to inhibit the release of these pro-inflammatory mediators in a dose-dependent manner...
  7. ncbi A molecular mechanism that stabilizes cooperative secretions in Pseudomonas aeruginosa
    Joao B Xavier
    Center for Systems Biology, Harvard University, 52 Oxford St, Cambridge, MA 02138, USA
    Mol Microbiol 79:166-79. 2011
    ..More generally, prudent regulation is a mechanism to stabilize cooperation...
  8. ncbi Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid
    Kelly S Doran
    Department of Pediatrics, Division of Infectious Diseases, UCSD School of Medicine, La Jolla, California 92093, USA
    J Clin Invest 115:2499-507. 2005
    ..Our data suggest that LTA expression on the GBS surface plays a role in bacterial interaction with BBB endothelium and the pathogenesis of neonatal meningitis...
  9. ncbi Glycolipids are involved in biofilm accumulation and prolonged bacteraemia in Enterococcus faecalis
    Christian Theilacker
    Division of Infectious Diseases, Department of Medicine, University Medical Center Freiburg, Germany
    Mol Microbiol 71:1055-69. 2009
    ..In several Gram-positive bacteria, membrane glycolipids have been implicated in biofilm formation...
  10. ncbi The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids
    S A Porcelli
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Annu Rev Immunol 17:297-329. 1999
    ..by CD1 has revealed the surprising finding that these are predominantly a variety of foreign lipids and glycolipids, including several found prominently in the cell walls and membranes of pathogenic mycobacteria...
  11. ncbi Rhamnolipids: diversity of structures, microbial origins and roles
    Ahmad Mohammad Abdel-Mawgoud
    INRS Institut Armand Frappier, 531 Boulevard des Prairies, Laval, QC, H7V 1B7, Canada
    Appl Microbiol Biotechnol 86:1323-36. 2010
    ....
  12. ncbi Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa
    U A Ochsner
    Institute for Biotechnology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich
    J Bacteriol 176:2044-54. 1994
    ..Additionally, such PG201::'rhlR' mutant strains lacked elastase activity, indicating that the RhlR protein is a pleiotropic regulator...
  13. ncbi The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells
    Shinji Oki
    Department of Immunology, National Institute of Neuroscience, National Center for Neuroscience and Psychiatry, Tokyo, Japan
    J Clin Invest 113:1631-40. 2004
    ..and that the length of the sphingosine chain determines the duration of NKT cell stimulation by CD1d-associated glycolipids. Furthermore, IFN-gamma production by NKT cells requires longer T cell receptor stimulation than is required ..
  14. ncbi Harnessing invariant NKT cells in vaccination strategies
    Vincenzo Cerundolo
    Tumour Immunology Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DU, UK
    Nat Rev Immunol 9:28-38. 2009
    ..In addition, we describe structural and kinetic analyses that assist in the design of optimal iNKT-cell agonists that could be used in the clinical setting as vaccine adjuvants...
  15. ncbi Timing and localization of rhamnolipid synthesis gene expression in Pseudomonas aeruginosa biofilms
    Yannick Lequette
    Department of Microbiology, 540 EMRB, Roy and Lucille Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Bacteriol 187:37-44. 2005
    ..The differential expression of rhlAB may play a role in the development of normal biofilm architecture...
  16. ncbi RhlA converts beta-hydroxyacyl-acyl carrier protein intermediates in fatty acid synthesis to the beta-hydroxydecanoyl-beta-hydroxydecanoate component of rhamnolipids in Pseudomonas aeruginosa
    Kun Zhu
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    J Bacteriol 190:3147-54. 2008
    ..We conclude that RhlA is necessary and sufficient to form the acyl moiety of RL and that the flux of carbon through FASII accelerates to support RL production and maintain a supply of acyl chains for phospholipid synthesis...
  17. ncbi A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells
    Kwok S Wun
    The Protein Crystallography Unit, ARC Centre of Excellence in Structural and Functional Microbial Genomics, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    Immunity 34:327-39. 2011
    ..Accordingly, we have provided a molecular basis for understanding how modifications in AGLs can result in striking alterations in the cellular response of NKT cells...
  18. ncbi Production of rhamnolipids by Pseudomonas aeruginosa
    Gloria Soberón-Chávez
    Departamento de Bioprocesos y Biocatálisis, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Appl Microbiol Biotechnol 68:718-25. 2005
    ..We also discuss the factors controlling the production of rhamnolipids and the proposed roles this biosurfactant plays in P. aeruginosa lifestyle...
  19. ncbi Pseudomonas aeruginosa virulence analyzed in a Dictyostelium discoideum host system
    Pierre Cosson
    , , , CH-1211 Geneva 4, Switzerland
    J Bacteriol 184:3027-33. 2002
    ..aeruginosa should show reduced virulence. This result was confirmed in a rat model of acute pneumonia. Thus, D. discoideum could be used as a simple nonmammalian host system to assess pathogenicity of P. aeruginosa...
  20. ncbi Axo-glial interactions regulate the localization of axonal paranodal proteins
    J L Dupree
    Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Cell Biol 147:1145-52. 1999
    ....
  21. ncbi Quorum sensing-dependent virulence during Pseudomonas aeruginosa colonisation and pneumonia in mechanically ventilated patients
    Thilo Köhler
    Service of Infectious Diseases, University Hospital Geneva, 4 rue Gabrielle Perret Gentil, Geneva 14, Switzerland
    Thorax 65:703-10. 2010
    ..The role of quorum sensing (QS), regulating virulence in this pathogen, during colonisation and development of VAP is unknown...
  22. ncbi Mycobacteria use their surface-exposed glycolipids to infect human macrophages through a receptor-dependent process
    Christelle Villeneuve
    , Institut de Pharmacologie et Biologie Structurale, , , 31077 Toulouse, France
    J Lipid Res 46:475-83. 2005
    ..GPL III, but not PIM2, also directed particle entry through the mannose receptor. Therefore, surface-exposed mycobacterial PIM and polar GPL participate in the receptor-dependent internalization of mycobacteria in human macrophages...
  23. ncbi Synthetic glycolipid OCH prevents insulitis and diabetes in NOD mice
    Miho Mizuno
    Department of Immunology, National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan
    J Autoimmun 23:293-300. 2004
    ....
  24. ncbi Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli
    Liana Tsenova
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute, Newark, New Jersey 07103, USA
    J Infect Dis 192:98-106. 2005
    ....
  25. ncbi Self-produced extracellular stimuli modulate the Pseudomonas aeruginosa swarming motility behaviour
    Julien Tremblay
    INRS Institut Armand Frappier, Laval Quebec, H7V 1B7, Canada
    Environ Microbiol 9:2622-30. 2007
    ..We propose a model explaining how HAAs and di-RLs together modulate the behaviour of swarming migrating cells by acting as self-produced negative and positive chemotactic-like stimuli...
  26. ncbi Mycobacterium leprae infection in monocyte-derived dendritic cells and its influence on antigen-presenting function
    Ken Hashimoto
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
    Infect Immun 70:5167-76. 2002
    ..M. leprae is a unique pathogen which remains resistant to DC-mediated T-cell immunity, at least in the early stages of infection...
  27. ncbi Trypanosomatid and fungal glycolipids and sphingolipids as infectivity factors and potential targets for development of new therapeutic strategies
    Erika Suzuki
    Division of Glycoconjugate Immunochemistry, Department of Biochemistry, Ed J L Prado, Rua Botucatu, 862, 04023 900, Sao Paulo, SP, Brazil
    Biochim Biophys Acta 1780:362-9. 2008
    ..Other pathogens, such as fungi, also present unique glycolipids which may have an important role for the fungal development and/or disease establishment...
  28. ncbi DC-SIGN mediates binding of dendritic cells to authentic pseudo-LewisY glycolipids of Schistosoma mansoni cercariae, the first parasite-specific ligand of DC-SIGN
    Sandra Meyer
    Institute of Biochemistry, Medical Faculty, Justus Liebig University Giessen, Germany
    J Biol Chem 280:37349-59. 2005
    ..Here we report that the CLR DC-SIGN mediates adhesion of DCs to authentic glycolipids derived from Schistosoma mansoni cercariae and their excretory/secretory products...
  29. ncbi Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa
    Peter Ø Jensen
    Department of Clinical Microbiology, Rigshospitalet, DK 2100 Copenhagen Ø, Denmark
    Microbiology 153:1329-38. 2007
    ..aeruginosa by disabling the PMNs, which are a major first line of defence of the host. Furthermore, the study emphasizes the inhibition of QS as a target for the treatment of infections with P. aeruginosa...
  30. ncbi Preferential T(h)2 polarization by OCH is supported by incompetent NKT cell induction of CD40L and following production of inflammatory cytokines by bystander cells in vivo
    Shinji Oki
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Int Immunol 17:1619-29. 2005
    ..In addition, highlighted in this study is the characteristic property of OCH that can induce the differential production of IFN-gamma or IL-4 according to the availability of IL-12...
  31. ncbi Lipid and glycolipid antigens of CD1d-restricted natural killer T cells
    Manjunatha M Venkataswamy
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Semin Immunol 22:68-78. 2010
    ..antigens provide an increasingly detailed picture of how the specific structural features of these lipids and glycolipids influence their ability to be presented to NKT cells and stimulate their diverse immunologic functions...
  32. ncbi Characteristic expression of Lewis-antigenic glycolipids in human ovarian carcinoma-derived cells with anticancer drug-resistance
    Masao Iwamori
    Department of Biochemistry, Faculty of Science and Technology, Kinki University, 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
    J Biochem 141:309-17. 2007
    ..In addition to the transporters expression, the amounts of glycolipids, particularly their longer carbohydrate structures, in the resistant cells increased to 3-4-fold of those in ..
  33. ncbi MALDI-TOF mass spectrometry of naturally occurring mixtures of monorhamnolipids and dirhamnolipids
    Neil P J Price
    Bioproducts and Biocatalysis, USDA ARS NCAUR, 1815 North University Street, Peoria, IL 61604, USA
    Carbohydr Res 344:204-9. 2009
    ..MALDI-TOFMS analysis allows the rapid screening of variously acylated rhamnolipids, and has potential for selective identification of new surfactants from microbial strains...
  34. ncbi Polyisoprenyl glycolipids as targets of CD1-mediated T cell responses
    D B Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Mol Life Sci 58:1461-74. 2001
    ..Human CD1c proteins mediate T cell recognition of polyisoprenyl glycolipids, evolutionarily conserved phosphoglycolipids, which function in glycan synthesis pathways...
  35. ncbi Murine glycosyltransferases responsible for the expression of globo-series glycolipids: cDNA structures, mRNA expression, and distribution of their products
    Yuko Fujii
    Department of Clinical Immunology, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Glycobiology 15:1257-67. 2005
    ..In this study, murine cDNAs of two glycosyltransferases responsible for the synthesis of globo-series glycolipids and mRNA expression of those genes were analyzed. Distribution of their products was also analyzed...
  36. ncbi Inhibitory effect on replicative DNA polymerases, human cancer cell proliferation, and in vivo anti-tumor activity by glycolipids from spinach
    Naoki Maeda
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, 518 Arise, Ikawadanicho, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Curr Med Chem 14:955-67. 2007
    We succeeded in purifying a major glycolipids fraction (i.e...
  37. ncbi Membrane glycolipids in stem cells
    Robert K Yu
    Institute of Molecular Medicine and Genetics and Institute of Neuroscience, Medical College of Georgia, Augusta, GA 30912, USA
    FEBS Lett 584:1694-9. 2010
    ..Recently, studies regarding the biological functions of glycolipids and cell surface microdomains (caveolae, lipid rafts, or glycolipid-enriched microdomains) in stem cells are ..
  38. ncbi Sophorolipids, microbial glycolipids with anti-human immunodeficiency virus and sperm-immobilizing activities
    Vishal Shah
    NSF Center for Biocatalysis and Bioprocessing of Macromolecules, Polytechnic University, Six Metrotech Center, Brooklyn, NY 11201, USA
    Antimicrob Agents Chemother 49:4093-100. 2005
    ..Its structure-activity relationship has been established for creating new analogs with less cytotoxicity and higher activity...
  39. ncbi Monoglucosyldiacylglycerol, a foreign lipid, can substitute for phosphatidylethanolamine in essential membrane-associated functions in Escherichia coli
    Malin Wikström
    Department of Biochemistry and Biophysics, Stockholm University, Sweden
    J Biol Chem 279:10484-93. 2004
    ..The reduced dependence on Mg(2+) and lack of correction by high monovalent salts strongly support the essential nature of the NB properties of MGlcDAG...
  40. ncbi T-cell responses to CD1-presented lipid antigens in humans with Mycobacterium tuberculosis infection
    Timo Ulrichs
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461, USA
    Infect Immun 71:3076-87. 2003
    ..tuberculosis-reactive T cells in healthy individuals with previous exposure to M. tuberculosis...
  41. ncbi Multiple roles of biosurfactants in structural biofilm development by Pseudomonas aeruginosa
    Sünje Johanna Pamp
    Centre for BioScience Technology, BioCentrum DTU, Building 301, The Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Bacteriol 189:2531-9. 2007
    ..aeruginosa biofilms demonstrated that the wild-type and rhlA and pilA mutant strains formed distinct subpopulations on top of each other dependent on their ability to migrate and produce biosurfactants...
  42. ncbi Neutral glycolipids of the filamentous fungus Neurospora crassa: altered expression in plant defensin-resistant mutants
    Chaeho Park
    Complex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602-7229, USA
    J Lipid Res 46:759-68. 2005
    ..The potential implications of these findings with respect to defensin resistance in the N. crassa mutants are discussed...
  43. ncbi A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components
    Rebecca A Butcher
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:14288-92. 2008
    ....
  44. ncbi Glycolipids from the formosan soft coral Lobophytum crassum
    Chih Hua Chao
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan ROC
    Chem Pharm Bull (Tokyo) 55:1720-3. 2007
    Three glycolipids (1--3), possessing a sugar moiety at C-2 of glycerol ether, have been isolated from the Formosan soft coral Lobophytum crassum...
  45. ncbi Effects of additives on the structure of rhamnolipid (biosurfactant): a small-angle neutron scattering (SANS) study
    Behnaz Dahrazma
    Department of Environmental Geology Faculty of Earth Science, Shahrood University of Technology, Shahrood 316 3619995161, Iran
    J Colloid Interface Sci 319:590-3. 2008
    ..The size of the aggregates in both acidic and basic condition is fine enough to ease the flow of the rhamnolipid solution through the porous media with the pore sizes as small as 200 nm...
  46. ncbi One-pot syntheses of immunostimulatory glycolipids
    Matthew Schombs
    Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    J Org Chem 75:4891-8. 2010
    b>Glycolipids containing alpha-linked galactosyl and glucosyl moieties have been shown to possess unique immunostimulatory activity creating a need for access to diverse and anomerically pure sources of these compounds for immunological ..
  47. ncbi Formation and characterization of planar lipid bilayer membranes from synthetic phytanyl-chained glycolipids
    T Baba
    Surface Engineering Laboratory, National Institute of Materials and Chemical Research, 1 1 Higashi, Tsukuba, Ibaraki, Japan
    Biochim Biophys Acta 1421:91-102. 1999
    ..characteristics and stability of the planar lipid bilayer membranes from the synthetic phytanyl-chained glycolipids, 1, 3-di-O-phytanyl-2-O-(beta-glycosyl)glycerols (Glc(Phyt)(2), Mal(N)(Phyt)(2)) were studied...
  48. ncbi Distribution of heterocyst glycolipids in cyanobacteria
    Thorsten Bauersachs
    NIOZ Royal Netherlands Institute for Sea Research, Department of Marine Organic Biogeochemistry, P O Box 59, 1790 AB Den Burg, The Netherlands
    Phytochemistry 70:2034-9. 2009
    ..of the families Nostocaceae and Rivulariaceae, capable of biosynthesising heterocysts, contained a suite of glycolipids consisting of sugar moieties glycosidically bound to long-chain diols, triols, keto-ols and keto-diols...
  49. ncbi Increase in rhamnolipid synthesis under iron-limiting conditions influences surface motility and biofilm formation in Pseudomonas aeruginosa
    Rivka Glick
    The Bacterial Biofilm Research Laboratory, The Institute for Nanotechnology and Advanced Materials, The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Bacteriol 192:2973-80. 2010
    ..These results highlight the importance of biosurfactant production in determining the mature structure of P. aeruginosa biofilms under iron-limiting conditions...
  50. ncbi Targeting glycoproteins or glycolipids and their metabolic pathways for antiparasite therapy
    Sumi Mukhopadhyay Nee Bandyopadhyay
    Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India
    Adv Exp Med Biol 625:87-102. 2008
    ..This review intends to focus on such lines, which will give us an insight into the future hope for development of novel therapeutic strategies through glycobiological platform for combating kinetoplastid infections...
  51. ncbi Critical role of amino acid position 343 of surfactant protein-D in the selective binding of glycolipids from Mycobacterium tuberculosis
    Tracy K Carlson
    Division of Infectious Diseases, Department of Internal Medicine, Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    Glycobiology 19:1473-84. 2009
    ..We conclude that the 343 position is critical in defining the binding pattern of SP-D proteins to M.tb and its mannosylated cell envelope components...
  52. ncbi Interferon induction by HIV-1-infected cells: a possible role of sulfatides or related glycolipids
    H Ankel
    Medical College of Wisconsin, Milwaukee 53226, USA
    Virology 221:113-9. 1996
    ..A partial homology of an epitope on the V3 loop of gp 120 with a previously suggested binding domain for sulfated glycoconjugates supports this conclusion...
  53. ncbi High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling
    Priscille Brodin
    Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Seongbuk gu, Seoul, Korea
    PLoS Pathog 6:e1001100. 2010
    ..the mutants in Rv1503c and Rv1506c were perturbed in the biosynthesis of acyltrehalose-containing glycolipids. Our results suggest that such glycolipids indeed play a critical role in the early intracellular fate of the ..
  54. ncbi Effects of galactolipid elimination on oligodendrocyte development and myelination
    J Marcus
    Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599 7250, USA
    Glia 30:319-28. 2000
    ..The data suggest that galactolipids play an important developmental role in regulating the maturation program and final number of oligodendrocytes...
  55. ncbi Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity
    Ya Jen Chang
    Division of Immunology and Allergy, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 121:57-69. 2011
    ..These findings suggest what we believe to be a novel pathway that can regulate AHR, and a new therapeutic strategy (treatment with glycolipid activators of this NKT cell population) for asthma...
  56. ncbi Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
    Yuki Kinjo
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 12:966-74. 2011
    ..Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, ..
  57. ncbi Glycolipids as immunostimulating agents
    Douglass Wu
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Bioorg Med Chem 16:1073-83. 2008
    ..A combination of structure-activity relationship (SAR), crystallographic studies, and discovery of new 'natural' antigens has led to greater understanding of the structural requirements for optimal natural killer T-cell activation...
  58. ncbi Priming and elongation: dissection of the lipoteichoic acid biosynthetic pathway in Gram-positive bacteria
    Iain C Sutcliffe
    Biomolecular and Biomedical Research Centre, School of Life Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK
    Mol Microbiol 79:553-6. 2011
    ..in this issue of Molecular Microbiology, provides confirmation of the priming step and further insights into the functional redundancy of lipoteichoic acid biosynthesis enzymes in Bacillus subtilis...
  59. ncbi Structural preferences of dioleoyl glycolipids with mono- and disaccharide head groups
    Jörg Howe
    Forschungszentrum Borstel, LG Biophysik, D 23845 Borstel, Germany
    Chem Phys Lipids 149:52-8. 2007
    The structural preferences of 1,2-dioleoyl-sn-glycerol glycolipids with glucose, galactose, maltose, and cellobiose as sugar head group were investigated under near physiological conditions with Fourier-transform infrared spectroscopy (..
  60. ncbi Saccharomyces cerevisiae-based molecular tool kit for manipulation of genes from gram-negative bacteria
    Robert M Q Shanks
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Appl Environ Microbiol 72:5027-36. 2006
    ..These tools can be used for genetic studies of pseudomonads and many other gram-negative bacteria...
  61. ncbi A blend of small molecules regulates both mating and development in Caenorhabditis elegans
    Jagan Srinivasan
    Howard Hughes Medical Institute and Biology Division, California Institute of Technology, 1200 E California Boulevard, Pasadena, California 91125, USA
    Nature 454:1115-8. 2008
    ..The ascaroside signalling system thus connects reproductive and developmental pathways and represents a unique example of structure- and concentration-dependent differential activity of signalling molecules...
  62. ncbi Physicochemical characterization and antimicrobial properties of rhamnolipids produced by Pseudomonas aeruginosa 47T2 NCBIM 40044
    E Haba
    , , Universidad de Barcelona, Joan XXIII s/n, E-08028 Barcelona, Spain
    Biotechnol Bioeng 81:316-22. 2003
    ....
  63. ncbi Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins
    Dapeng Zhou
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Science 303:523-7. 2004
    ..LTPs constitute a previously unknown link between lipid metabolism and immunity and are likely to exert a profound influence on the repertoire of self, tumor, and microbial lipid antigens...
  64. ncbi Thermodynamics of the interaction of a dirhamnolipid biosurfactant secreted by Pseudomonas aeruginosa with phospholipid membranes
    Francisco J Aranda
    Departamento de Bioquimica y Biologia Molecular A, Facultad de Veterinaria, Universidad de Murcia, E 30100 Espinardo, Murcia, Spain
    Langmuir 23:2700-5. 2007
    ..The values obtained for the cmc and the partition constant are considered in relation to the surfactant potency of dirhamnolipids...
  65. ncbi Synthesis of novel NBD-GM1 and NBD-GM2 for the transfer activity of GM2-activator protein by a FRET-based assay system
    Gunter Schwarzmann
    Kekulé Institute für Organische Chemie und Biochemie, Gerhard Domagk Strasse 1, D 53121 Bonn, Germany
    Glycobiology 15:1302-11. 2005
    ..Both fluorescent glycolipids exhibited an extremely low off-rate in model membranes and displayed very efficient resonance energy transfer ..
  66. ncbi Immunology. The Robin Hood of antigen presentation
    Gennaro De Libero
    Department of Research, University Hospital Basel, Basel CH-4031, Switzerland
    Science 303:485-7. 2004
  67. ncbi iNKT-cell responses to glycolipids
    Vrajesh V Parekh
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Crit Rev Immunol 25:183-213. 2005
    ..Preclinical studies in mice have demonstrated that alpha-GalCer and related glycolipids can protect mice against a variety of diseases, including cancer, infections, and several autoimmune and ..
  68. ncbi Comparative study of lipid composition of two halotolerant alga, Dunaliella bardawil and Dunaliella salina
    A Vanitha
    Plant Cell Biotechnology Department, Central Food Technological Research Institute, Mysore, India
    Int J Food Sci Nutr 58:373-82. 2007
    ....
  69. ncbi Development and trends of biosurfactant analysis and purification using rhamnolipids as an example
    M Heyd
    Water Technology and Geotechnology Division, Institute for Technical Chemistry, Forschungszentrum Karlsruhe GmbH, 76021, Karlsruhe, Germany
    Anal Bioanal Chem 391:1579-90. 2008
    ..Furthermore, rhamnolipid purification from a fermentation broth will be considered depending on the following application...
  70. ncbi Simultaneous production of polyhydroxyalkanoates and rhamnolipids by Pseudomonas aeruginosa
    Katsutoshi Hori
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Biotechnol Bioeng 78:699-707. 2002
    ....
  71. ncbi Surface forces and properties of foam films from rhamnolipid biosurfactants
    R Cohen
    Institute of Physical Chemistry, Bulgarian Academy of Sciences, Acad G Bonchev Str, Bl 11, 1113 Sofia, Bulgaria
    Adv Colloid Interface Sci 134:24-34. 2007
    ..Experiments with model lung surfactant (Infasurf) foam films with rhamnolipid added outline a perspective for the potential application of the foam film for investigating the effect of rhamnolipids on human alveoli...
  72. ncbi Thermodynamic and structural changes associated with the interaction of a dirhamnolipid biosurfactant with bovine serum albumin
    Marina Sanchez
    Laboratorio de Microbiologia, Facultad de Farmacia, Universidad de Barcelona, Joan XXIII s n, E 08028, Barcelona, Spain
    Langmuir 24:6487-95. 2008
    ..The consequences of these results in relation to possible applications of these dirhamnolipid biosurfactants for protein studies are discussed...
  73. ncbi Chemical structures and biological activities of rhamnolipids produced by Pseudomonas aeruginosa B189 isolated from milk factory waste
    Benjamas Thanomsub
    Department of Microbiology, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand
    Bioresour Technol 97:2457-61. 2006
    ..25 microg/mL while rhamnolipid b showed MIC against insect cell line C6/36 at 50 microg/mL...
  74. ncbi Aggregation behaviour of a dirhamnolipid biosurfactant secreted by Pseudomonas aeruginosa in aqueous media
    Marina Sanchez
    Departamento de Bioquimica y Biologia Molecular A, Facultad de Veterinaria, Universidad de Murcia, E 30100 Murcia, Spain
    J Colloid Interface Sci 307:246-53. 2007
    ..The relevance of this aggregation behaviour is discussed with respect to the molecular basis of its activities...
  75. ncbi rhlA is required for the production of a novel biosurfactant promoting swarming motility in Pseudomonas aeruginosa: 3-(3-hydroxyalkanoyloxy)alkanoic acids (HAAs), the precursors of rhamnolipids
    Eric Déziel
    INRS Institut Armand Frappier, Laval, Quebec, Canada H7V 1B7
    Microbiology 149:2005-13. 2003
    Pseudomonas aeruginosa produces extracellular glycolipids composed of L-rhamnose and 3-hydroxyalkanoic acid called rhamnolipids...
  76. ncbi Production of different types of mannosylerythritol lipids as biosurfactants by the newly isolated yeast strains belonging to the genus Pseudozyma
    Masaaki Konishi
    Research Institute for Innovation in Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, 305 8565, Japan
    Appl Microbiol Biotechnol 75:521-31. 2007
    ....
  77. ncbi Production of new types of sophorolipids by Candida batistae
    Masaaki Konishi
    Research Institute for Innovation in Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology, AIST Tsukuba Central, Ibaraki, Japan
    J Oleo Sci 57:359-69. 2008
    ..From these results, the phylogenetic approach should lead to the discovery of new biosurfactant producers, and the yeast product possessing high hydrophilicity may facilitate a broad range of applications for SLs...
  78. ncbi Characterization of new glycolipid biosurfactants, tri-acylated mannosylerythritol lipids, produced by Pseudozyma yeasts
    Tokuma Fukuoka
    Research Institute for Innovation in Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology, AIST Tsukuba Central 5 2, 1 1 1 Higashi, Tsukuba, Ibaraki, Japan
    Biotechnol Lett 29:1111-8. 2007
    ..In the course of MEL production from soybean oil by P. antarctica and P. rugulosa, some new extracellular glycolipids (more hydrophobic than the previously reported di-acylated MELs) were found in the culture medium...
  79. ncbi Microfiltration of butter serum upon casein micelle destabilization
    R Rombaut
    Laboratory of Food Technology and Engineering, Department of Food Safety and Food Quality BW07, Faculty of Bioscience Engineering, Ghent University, Belgium
    J Dairy Sci 89:1915-25. 2006
    ..The protein fraction was further characterized by sodium dodecyl sulfate-PAGE. It was shown that sodium citrate greatly enhanced casein transmission through the membrane, but at the expense of substantial losses of polar lipids...
  80. ncbi Preparation of liposomes from milk fat globule membrane phospholipids using a microfluidizer
    A K Thompson
    Riddet Centre, Massey University, Private Bag 11 222, Palmerston North, New Zealand
    J Dairy Sci 89:410-9. 2006
    ....
  81. ncbi Contribution to the study of camel milk fat globule membrane
    Nadia Laadhar Karray
    Unité Analyses Alimentaires, BPW, Sfax, Tunisie
    Int J Food Sci Nutr 57:382-90. 2006
    ..The thermal study revealed an important proportion of high-melting triacylglycerols that involves fatty acids with long chains...
  82. ncbi Phospholipid, sphingolipid, and fatty acid compositions of the milk fat globule membrane are modified by diet
    Christelle Lopez
    INRA Agrocampus Rennes, UMR 1253 Science et Technologie du Lait et de l Oeuf, 65 rue de Saint Brieuc, 35 042 Rennes Cedex, France
    J Agric Food Chem 56:5226-36. 2008
    ..The technological, sensorial, and nutritional consequences of these changes in the lipid composition of the MFGM induced by dietary manipulation remain to be elucidated...
  83. ncbi Concentration of polar MFGM lipids from buttermilk by microfiltration and supercritical fluid extraction
    J C Astaire
    Dairy Products Technology Center, Department of Agriculture, California Polytechnic State University, San Luis Obispo, CA 93407, USA
    J Dairy Sci 86:2297-307. 2003
    ..Particle size analysis revealed an impact of SFE on the product structure. The efficiency of the SFE system using the microfiltration-processed powder was compared much more favorably to using buttermilk powder...
  84. ncbi Characterization of a low molecular weight glycolipid antigen from Cryptosporidium parvum
    Jeffrey W Priest
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Biol Chem 278:52212-22. 2003
    ..We are currently working to determine the role that these glycolipids may play in the development of disease and in the clearance of infection.
  85. ncbi Factors affecting the concentration of sphingomyelin in bovine milk
    E L F Graves
    Department of Animal Sciences, University of Illinois, Urbana 61801, USA
    J Dairy Sci 90:706-15. 2007
    ..However, efforts to produce milk with a greater sphingomyelin content through altering management and nutrition are unlikely to be successful...
  86. ncbi Glycolipids and phospholipids as natural CD1d-binding NKT cell ligands
    M Tsuji
    HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, New York, New York 10016, USA
    Cell Mol Life Sci 63:1889-98. 2006
    ..Several glycolipids and phospholipids derived from mammalian, bacterial, protozoan and plant species have recently been identified ..
  87. ncbi Glycoinositolphospholipid from Trypanosoma cruzi: structure, biosynthesis and immunobiology
    Jose O Previato
    , , Bloco G, Universidade Federal do Rio de Janeiro, , , Rio de Janeiro, RJ, Brazil
    Adv Parasitol 56:1-41. 2004
    ..However, a more detailed understanding might enable the development of specific inhibitors of parasite-specific enzymes and lead to novel drugs to ameliorate Chagas disease...
  88. ncbi CD1 trafficking: invariant chain gives a new twist to the tale
    D B Moody
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Smith Building Room 514, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Immunity 15:861-5. 2001
    ..Their results provide intriguing evidence for the involvement of two critical components of the MHC class II endosomal processing pathway, cathepsin S and the invariant chain, in the normal functioning of CD1...
  89. ncbi Natronolimnobius baerhuensis gen. nov., sp. nov. and Natronolimnobius innermongolicus sp. nov., novel haloalkaliphilic archaea isolated from soda lakes in Inner Mongolia, China
    Takashi Itoh
    Japan Collection of Microorganisms, RIKEN BioResource Center, Wako, Saitama 351 0198, Japan
    Extremophiles 9:111-6. 2005
    ..No glycolipids were detected...
  90. ncbi Novel bacterial polar lipids containing ether-linked alkyl chains, the structures and biological properties of the four major glycolipids from Propionibacterium propionicum PCM 2431 (ATCC 14157T)
    Mariola Pasciak
    Institute of Immunology and Experimental Therapy, The Polish Academy of Sciences, Weigla 12, Wrocław PL 53 114, Poland
    J Biol Chem 278:3948-56. 2003
    ..propionicum (type strain) gave in TLC analysis the characteristic glycolipid profile containing four major glycolipids, labeled G(1) through G(4)...
  91. ncbi Inositolphosphoceramide is not a substrate for the first steps in the biosynthesis of glycoinositolphospholipids in Trypanosoma cruzi
    Laura E Bertello
    CIHIDECAR, , Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, , Ciudad Universitaria, 1428 Buenos Aires, Argentina
    Mol Biochem Parasitol 133:71-80. 2004
    ..Several [3H]-Man labelled GPI precursors were obtained by in vitro GDP[3H]-Man labelling in the presence of UDPGlcNAc. All of them were sensitive to PI-PLC and to saponification conditions, thus, supporting a glycerolipid structure...
  92. ncbi Bile salts and cholesterol induce changes in the lipid cell membrane of Lactobacillus reuteri
    M P Taranto
    Centro de Referencia para Lactobacilos (CERELA-CONICET, Chacabuco, , , Argentina
    J Appl Microbiol 95:86-91. 2003
    ..Fatty acids were determined by analytical gas-liquid chromatography, and phospholipids and glycolipids by colorimetric techniques. The cells from different culture media were subjected to cold and acid stress...
  93. ncbi Characterization of three glycosyltransferases involved in the biosynthesis of the phenolic glycolipid antigens from the Mycobacterium tuberculosis complex
    Esther Perez
    Département Mécanismes Moléculaires des Infections Mycobactériennes, Institut de Pharmacologie et Biologie Structurale, CNRS and Université Paul Sabatier Unité Mixte de Recherche 5089, 205 route de Narbonne, 31077 Toulouse Cedex, France
    J Biol Chem 279:42574-83. 2004
    ..The recombinant strains produced provide the tools to study the role of the carbohydrate domain of PGL-tb and p-HBAD in M. tuberculosis pathogenesis...
  94. ncbi Enhanced solvent extraction of polar lipids associated with rubber particles from Hevea brasiliensis
    Frederic Bonfils
    CIRAD CP, 73 rue Jean François Breton, 34398 Montpellier, France
    Phytochem Anal 18:103-8. 2007
    ..This technique is proposed as an alternative to traditional extraction methods used for solid natural rubber as it offers advantages with respect to ease of application, extract quality, extraction yields and reproducibility...
  95. ncbi Effect of surfactant sucrose ester on physical properties of dairy whipped emulsions in relation to those of O/W interfacial layers
    A Tual
    Degussa Food Ingredients, Application Service Center, 50500 Baupte, France
    J Colloid Interface Sci 295:495-503. 2006
    ..Consequently, with the recipe and manufacturing process used to produce dairy foams, there exists a compromise in sucrose ester content with regards to manufacture and shelf-life of dairy foams...
  96. ncbi Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complex
    Esther Perez
    Département Mécanismes Moléculaires des Infections Mycobactériennes, Institut de Pharmacologie et Biologie Structurale, CNRS and Université Paul Sabatier Unité Mixte de Recherche 5089, 205 route de Narbonne, 31077 Toulouse Cedex, France
    J Biol Chem 279:42584-92. 2004
    ....
  97. ncbi Polyhydroxyalkanoic acids and rhamnolipids are synthesized sequentially in hexadecane fermentation by Pseudomonas aeruginosa ATCC 10145
    C Chayabutra
    Department of Chemical Engineering, The University of Akron, Akron, Ohio 44325-3906, USA
    Biotechnol Prog 17:419-23. 2001
    ..41 (+/-0.06); beta-hydroxydodecanoic acid, 0.11 (+/-0.05), beta-hydroxytetradecanoic acid, 0.11 (+/-0.06), and beta-hydroxyhexadecanoic acid, 0.12 (+/-0.06). beta-Hydroxydecanoic acid was clearly the primary monomer...
  98. ncbi The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation
    Corinna McCarthy
    Tumour Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Exp Med 204:1131-44. 2007
    ..This indirect effect provides a general mechanism by which lipid-specific lymphocytes are capable of recognizing both the group head and the length of lipid antigens, ensuring greater specificity of antigen recognition...
  99. ncbi Structural insight into natural killer T cell receptor recognition of CD1d
    Natalie A Borg
    Natalie A. Borg and Jamie Rossjohn, Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia 3800
    Adv Exp Med Biol 598:20-34. 2007
  100. ncbi Complete polar lipid composition of Thermoplasma acidophilum HO-62 determined by high-performance liquid chromatography with evaporative light-scattering detection
    Haruo Shimada
    Department of Molecular Biology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
    J Bacteriol 184:556-63. 2002
    ..Three types of ether lipids were found: phospholipids, glycolipids, and phosphoglycolipids. The two phospholipids had glycerophosphate as the phosphoester moiety...
  101. ncbi The crystal structure of human CD1d with and without alpha-galactosylceramide
    Michael Koch
    Cancer Research UK Receptor Structure Research Group, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Nat Immunol 6:819-26. 2005
    ..These structures provide clues as to how CD1 molecules load glycolipids as well as data to guide the design of new therapeutic agents.

Research Grants78

  1. NKT Cells Immunotherapy: Targeting Dendritic Cells with Glycolipid Liposomes
    Peng Wang; Fiscal Year: 2007
    ..In contrast, a specialized subpopulation of T cells called NKT cells recognize glycolipids antigens presented by the MHC class l-like molecule; CD1d...
  2. The Role of Glycolipids and CD1 in the Immunology of Leishmania Infection
    Laurence U Buxbaum; Fiscal Year: 2010
    ..NKT cells are activated by an unusual protein called CD1, which is involved in immune responses provoked by glycolipids (like GIPLs). The way in which CD1 and NKT cells work in infection is not well understood...
  3. Biogenesis of lipoarabinomannan in mycobacteria
    Mary Jackson; Fiscal Year: 2010
    ..PIM) and their multiglycosylated counterparts, lipomannan (LM) and lipoarabinomannan (LAM) are complex glycolipids and lipoglycans found in the envelopes of all mycobacterial species...
  4. LIPID A MODIFICATION SYSTEMS IN GRAM-NEGATIVE BACTERIA
    CHRISTIAN RAETZ; Fiscal Year: 2007
    Lipopolysaccharides (LPSs) are remarkable glycolipids that comprise the outer surfaces of Gram-negative bacteria, including the symbiotic organism, Rhizobium leguminosamm...
  5. BIOSYNTHESIS AND REGULATION OF SUBSTITUTED SIALIC ACIDS
    Ajit Varki; Fiscal Year: 1990
    Sialic acids, which are the outermost sugars on the glycoproteins and glycolipids of mammalian cells, can be substituted at the 4,7,8, and 9 positions with O-acetyl esters (or other less common substitutions) in a tissue-specific fashion...
  6. Role of Nuclear Gangliosides in Neuronal Function
    Robert W Ledeen; Fiscal Year: 2010
    ..plasma membrane, but a number of intracellular mechanisms are now known to be mediated and modulated by these glycolipids. Our work has shown GM1 in particular to have a critical role regulating Ca2+ homeostasis in the nucleus and ..
  7. Structure and function of family 1 glycosyltransferases
    R Garavito; Fiscal Year: 2006
    ..units onto the target compounds to create a diverse set of macromolecules in plants, animals, and bacteria: glycolipids, lipopolysaccharides, the glycan structures in plants, glycoproteins, and glycosylated natural products of ..
  8. Xenograft-like rejection of tumors in a-gal glycolipids
    URI GALILI GALILI; Fiscal Year: 2010
    ..We will study this treatment in a unique mouse model that simulates the pertinent human immunological parameters. Success in the studies in the mouse model will enable us to apply this treatment to cancer patients. ..
  9. IMMUNOCHEMISTRY OF GONOCOCCAL LIPOPOLYSACCHARIDE
    JOHN GRIFFISS; Fiscal Year: 2003
    ..LOS are outer membrane glycolipids that have a glycose moiety that consists of proximal Basal Region and three short distal chains, termed alpha ..
  10. SORTING OF A LIPID-PROTEIN COMPLEX IN EPITHELIAL CELLS
    Deborah Brown; Fiscal Year: 1993
    ..Membrane complexes that contain both glycolipids and GPI-anchored proteins have been isolated, using their surprising insolubility in non-ionic detergents...
  11. CD1 AND BCR/Fc RECEPTOR TARGETED LIGAND
    Grant Yeaman; Fiscal Year: 2001
    ..Typically, CD1 molecules present lipids or glycolipids to T cells. CD1 ligands are associated with T cells specific for M. tuberculosis...
  12. SHORT- AND LONG-RANGE FORCES BETWEEN MEMBRANCE SURFACES
    THOMAS MC INTOSH; Fiscal Year: 1993
    ..In particular, these pressures will be measured for bilayers containing various glycolipids or containing lipids with covalently attached polyethylene glycol (PEG)...
  13. GLYCOSPHINGOLIPID METABOLISM AND MENTAL RETARDATION
    Glyn Dawson; Fiscal Year: 2000
    The broad, long-term objectives are to understand the role of glycolipids (glycoshingolipids (GSL) and inositolphosphoglycerides) in normal nervous function and the pathogenic processes involving them which lead to mental retardation...
  14. Glycolipid Trafficking of Cholera Toxin by Lipid Rafts
    David Saslowsky; Fiscal Year: 2007
    The goal of this application is to understand how epithelial cells of the intestinal mucosa sort membrane glycolipids into the retrograde trafficking pathway from the plasma membrane (PM) to the endoplasmic reticulum (ER), a route ..
  15. GLYCOLIPIDS AND HEMOLYTIC UREMIC SYNDROME
    David Haslam; Fiscal Year: 2002
    ..In almost all cases, verotoxins (shiga-like toxins) released by enterohemorrhagic E. coli bind to glycolipids on the endothelial cells, are then routed to the endoplasmic reticulum, and thereby inactivate the 28S ..
  16. An Untested Approach: Biomarkers for Colon Cancer
    Khushi Matta; Fiscal Year: 2007
    ..is known that cancer is associated with alterations in the glycosylation patterns of glycoconjugates including glycolipids and glycoproteins...
  17. Role of ER-Localized Chaperones in Toxin Pathogenesis
    David Haslam; Fiscal Year: 2006
    ..After binding to cell surface glycolipids, the toxin is internalized and trafficked in retrograde fashion to the Golgi and endoplasmic reticulum (ER)...
  18. Naturally Occurring IgM Anti-Leucocyte Autoantibodies Protect Against Renal IRI
    MARK DOUGLAS OKUSA; Fiscal Year: 2010
    ..Based on these findings we questioned whether IgM- ALA downregulate inflammation that accompanies renal IRI. Glycolipids released after ischemic injury are processed and presented by resident dendritic cells (DC), in presence of ..