alpha linolenic acid

Summary

Summary: A fatty acid that is found in plants and involved in the formation of prostaglandins.

Top Publications

  1. ncbi Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio
    Petra L L Goyens
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 84:44-53. 2006
  2. ncbi Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women
    Guixiang Zhao
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    J Nutr 134:2991-7. 2004
  3. ncbi Beneficial effects of alpha linolenic acid rich flaxseed oil on growth performance and hepatic cholesterol metabolism in high fat diet fed rats
    K Vijaimohan
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India
    Life Sci 79:448-54. 2006
  4. ncbi Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells
    Guixiang Zhao
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    Biochem Biophys Res Commun 336:909-17. 2005
  5. ncbi Human requirement for N-3 polyunsaturated fatty acids
    A P Simopoulos
    The Center for Genetics Nutrition and Health, Washington, DC 20009, USA
    Poult Sci 79:961-70. 2000
  6. ncbi Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men
    Nahed Hussein
    Centre for Nutrition and Food Safety, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom
    J Lipid Res 46:269-80. 2005
  7. ncbi Delayed cell migration in the developing rat brain following maternal omega 3 alpha linolenic acid dietary deficiency
    E Yavin
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Neuroscience 162:1011-22. 2009
  8. ncbi Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula
    Clifford Mayes
    Neonatal Intensive Care Unit, Royal Maternity Hospital, Belfast, UK
    Pediatr Res 59:271-5. 2006
  9. ncbi Levels of the n-3 fatty acid eicosapentaenoic acid in addition to those of alpha linolenic acid are significantly raised in blood lipids by the intake of four walnuts a day in humans
    Franca Marangoni
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Nutr Metab Cardiovasc Dis 17:457-61. 2007
  10. ncbi Metabolism of alpha-linolenic acid in humans
    G C Burdge
    Institute of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Prostaglandins Leukot Essent Fatty Acids 75:161-8. 2006

Detail Information

Publications230 found, 100 shown here

  1. ncbi Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio
    Petra L L Goyens
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 84:44-53. 2006
    ..Human in vivo data on dietary determinants of alpha-linolenic acid (ALA; 18:3n-3) metabolism are scarce...
  2. ncbi Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women
    Guixiang Zhao
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    J Nutr 134:2991-7. 2004
    ..05); the ALA Diet decreased HDL cholesterol and apolipoprotein AI compared with the AAD (P < 0.05). ALA appears to decrease CVD risk by inhibiting vascular inflammation and endothelial activation beyond its lipid-lowering effects...
  3. ncbi Beneficial effects of alpha linolenic acid rich flaxseed oil on growth performance and hepatic cholesterol metabolism in high fat diet fed rats
    K Vijaimohan
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India
    Life Sci 79:448-54. 2006
    ..The results of the present study demonstrate that FO may be developed as a useful therapy for hyperlipidemia through reducing hepatic lipids, thereby proving its hypolipidemic activity...
  4. ncbi Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells
    Guixiang Zhao
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    Biochem Biophys Res Commun 336:909-17. 2005
    ..The results indicate that the anti-inflammatory effects of polyunsaturated fatty acids may be, in part, due to the inhibition of NF-kappaB activation via activation of PPARgamma...
  5. ncbi Human requirement for N-3 polyunsaturated fatty acids
    A P Simopoulos
    The Center for Genetics Nutrition and Health, Washington, DC 20009, USA
    Poult Sci 79:961-70. 2000
    ..To obtain the recommended AI, it will be necessary to consider the issues involved in enriching the food supply with n-3 PUFA in terms of dosage, safety, and sources of n-3 fatty acids...
  6. ncbi Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men
    Nahed Hussein
    Centre for Nutrition and Food Safety, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom
    J Lipid Res 46:269-80. 2005
    ..e., AA, 0.2%; EPA, 0.3%; and DPA, 0.02%) and varied directly with precursor concentrations and inversely with concentrations of fatty acids of the alternative series. [13C]DHA formation was very low (<0.01%) with no dietary influences...
  7. ncbi Delayed cell migration in the developing rat brain following maternal omega 3 alpha linolenic acid dietary deficiency
    E Yavin
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Neuroscience 162:1011-22. 2009
    ..levels of docosahexaenoic acid (DHA, 22:6n-3), the major polyunsaturated fatty acid (FA) synthesized from alpha linolenic acid (ALA, 18:3n-3), have been implicated in changes in neurotransmitter production, ion channel disruption and ..
  8. ncbi Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula
    Clifford Mayes
    Neonatal Intensive Care Unit, Royal Maternity Hospital, Belfast, UK
    Pediatr Res 59:271-5. 2006
    ..The most abundant omega-3 fatty acid in pre-term formulas is alpha linolenic acid (ALNA), the precursor of DHA...
  9. ncbi Levels of the n-3 fatty acid eicosapentaenoic acid in addition to those of alpha linolenic acid are significantly raised in blood lipids by the intake of four walnuts a day in humans
    Franca Marangoni
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Nutr Metab Cardiovasc Dis 17:457-61. 2007
    Ingestion of alpha linolenic acid (ALA), with the richest source among dry fruits such as walnuts, is associated with cardiovascular prevention...
  10. ncbi Metabolism of alpha-linolenic acid in humans
    G C Burdge
    Institute of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Prostaglandins Leukot Essent Fatty Acids 75:161-8. 2006
    ..These gender differences may be an important consideration in making dietary recommendations for n-3 PUFA intake...
  11. ncbi Alpha-linolenic acid metabolism in men and women: nutritional and biological implications
    Graham Burdge
    Institute of Human Nutrition, Biomedical Science Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Curr Opin Clin Nutr Metab Care 7:137-44. 2004
    ..The extent to which increasing dietary alpha-linolenic acid intake alters the concentrations of longer-chain n-3 fatty acids is described. The biological and nutritional implications of these findings are discussed...
  12. pmc Effect of alpha linolenic acid on cardiovascular risk markers: a systematic review
    E Wendland
    Graduate Studies Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Heart 92:166-9. 2006
    To determine whether dietary supplementation with alpha linolenic acid (ALA) can modify established and emerging cardiovascular risk markers.
  13. ncbi Alterations in brain function after loss of docosahexaenoate due to dietary restriction of n-3 fatty acids
    N Salem
    Division of Intramural Clinical and Biological Research, National Institutes on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
    J Mol Neurosci 16:299-307; discussion 317-21. 2001
    ..No difference could be observed in the hippocampal gross morphology. This study demonstrates the importance of providing a source of n-3 fatty acids during mammalian growth and development...
  14. ncbi Vitamin A deficiency enhances docosahexaenoic and osbond acids in liver of rats fed an alpha linolenic acid-adequate diet
    D Zhou
    Institute of Brain Chemistry and Human Nutrition, London Metropolitan University, London, United Kingdom
    Lipids 41:213-9. 2006
    ..Hence, there is a need for a further study to unravel the mechanism by which vitamin A influences membrane DHA and OA...
  15. ncbi Flaxseed and cardiovascular risk
    LeAnne T Bloedon
    School of Nursing, The Center for Experimental Therapeutics, Division of General Internal Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Nutr Rev 62:18-27. 2004
    ..Data on the antiplatelet, antioxidant, and hypotensive effects of flaxseed, however, are inconclusive. More research is needed to define the role of this functional food in reducing cardiovascular risk...
  16. ncbi Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses
    Petra L L Goyens
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    J Lipid Res 46:1474-83. 2005
    ..The limited incorporation of dietary ALA into the hepatic phospholipid pool contributes to the low hepatic conversion of ALA into EPA. A low conversion of ALA-derived EPA into DPA might be an additional obstacle for DHA synthesis...
  17. ncbi Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells
    A Vecchini
    Department of Internal Medicine, Section of Biochemistry, University of Perugia, Perugia, Italy
    J Lipid Res 45:308-16. 2004
    ..Conversely, it was observed that apoptosis induced by the alpha-linolenic acid-enriched diet correlated with a decrease in arachidonate content in hepatoma cells and decreased cyclooxygenase-2 expression...
  18. ncbi Gamma-linolenic acid therapy of human gliomas
    Ajay Bakshi
    Department of Neurosurgery, Vidyasagar Institute of Mental Health and Neurosciences, New Delhi, India
    Nutrition 19:305-9. 2003
    ..We investigated the effect of intratumoral administration of gamma-linolenic acid (GLA) in human gliomas...
  19. ncbi Diet (n-3) polyunsaturated fatty acid content and parity interact to alter maternal rat brain phospholipid fatty acid composition
    Beth Levant
    The Smith Mental Retardation Research Center, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Nutr 136:2236-42. 2006
    ....
  20. pmc Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes
    S Vartak
    Radiation Research Laboratory, Department of Radiology, University of Iowa, Iowa City 52242, USA
    Br J Cancer 77:1612-20. 1998
    ..The lipoxygenase inhibitor NDGA did not affect the toxicity produced by GLA. Thus, GLA is toxic to the neoplastic astrocytoma cells but not to normal astrocytes...
  21. ncbi Differential effects of modulation of docosahexaenoic acid content during development in specific regions of rat brain
    Beth Levant
    Department of Pharmacology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Lipids 41:407-14. 2006
    ..These differential effects may contribute to the specific neurochemical and behavioral effects observed in animals with variation in brain DHA content...
  22. ncbi Sensitivity of fetus and pups to excess levels of maternal intakes of alpha linolenic acid at marginal protein levels in Wistar rats
    Shobha Suryaprakasa Rao
    Animal Science Division, Biometry and Nutrition Unit, Agharkar Research Institute, GG Agarkar Road, Pune, India
    Reprod Toxicol 24:333-42. 2007
    ..Present study examined whether alpha linolenic acid, primary vegetarian dietary omega 3 fatty acid source and precursor to cellular membrane phospholipid ..
  23. ncbi DHA status of vegetarians
    Thomas A B Sanders
    Nutritional Sciences Division TABS, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE19NH, UK
    Prostaglandins Leukot Essent Fatty Acids 81:137-41. 2009
    ..Docosahexaenoic acid (22:6n-3; DHA) is absent from vegan diets and present in limited amounts in vegetarian diets...
  24. pmc Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats
    Beth Levant
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Psychoneuroendocrinology 33:1279-92. 2008
    ..Furthermore, the data are consistent with findings in depressed humans, and thus support a role for DHA as a factor in the etiologies of depressive illnesses, particularly postpartum depression...
  25. pmc An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans
    Amy E Griel
    Department of Nutritional Sciences, 126 S Henderson Bldg, The Pennsylvania State University, University Park, PA 16802, USA
    Nutr J 6:2. 2007
    ..The results indicate that plant sources of dietary n-3 PUFA may have a protective effect on bone metabolism via a decrease in bone resorption in the presence of consistent levels of bone formation...
  26. ncbi Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, UK
    Br J Nutr 90:311-21. 2003
    ..This suggests regulation of ALNA conversion may limit the influence of variations in dietary n-3 fatty acid intake on plasma lipid compositions...
  27. ncbi Adipose tissue biomarkers of fatty acid intake
    Ana Baylin
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 76:750-7. 2002
    ..Biomarkers can provide a more accurate measure of long-term intake than can dietary questionnaires...
  28. ncbi Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study
    Margaret D Griffin
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, United Kingdom
    Am J Clin Nutr 84:1290-8. 2006
    ..It has been hypothesized that the dietary ratio of n-6 to n-3 (n-6:n-3) polyunsaturated fatty acids (PUFAs) may have favorable effects on these risk factors by increasing insulin sensitivity...
  29. ncbi Effects of long chain fatty acids on lipid and glucose metabolism in monolayer cultures of bovine hepatocytes
    D G Mashek
    Department of Dairy Science, University of Wisconsin, Madison 53706, USA
    J Dairy Sci 86:2390-6. 2003
    ..Overall, fatty acids differed in their effects on lipid and glucose metabolism in monolayer cultures of bovine hepatocytes with C22:6 eliciting the most profound changes...
  30. ncbi Metabolic fate of long-chain unsaturated fatty acids and their effects on palmitic acid metabolism and gluconeogenesis in bovine hepatocytes
    D G Mashek
    Department of Dairy Science, University of Wisconsin, Madison 53706, USA
    J Dairy Sci 85:2283-9. 2002
    ..Long-chain fatty acids vary in their routes of metabolism and influence palmitic acid metabolism and gluconeogenesis in bovine hepatocytes...
  31. ncbi Dietary alpha-linolenic acid suppresses the formation of lysophosphatidic acid, a lipid mediator, in rat platelets compared with linoleic acid
    Daisuke Miyazawa
    Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabedori, Mizuhoku, 467 8603 Nagoya, Japan
    Life Sci 73:2083-90. 2003
    ..6-fold in the high-LA group and 4.1-fold in the high-ALA-group by thrombin-treatment. The formation of [32P] LPA in activated platelets was reduced by 35% in the high-ALA group...
  32. ncbi Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio
    Gwendolyn Barcelo-Coblijn
    Biological Research Center, Institute of Biochemistry, Hungarian Academy of Sciences, H 6701 Szeged, Hungary
    Biochim Biophys Acta 1632:72-9. 2003
    ..It was suggested that alteration in membrane architecture and function coupled with alterations in gene expression profiles may contribute to the observed beneficial impact of n-3 type polyunsaturated fatty acids on cognitive functions...
  33. ncbi Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids
    Michael J James
    Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia
    Am J Clin Nutr 77:1140-5. 2003
    ....
  34. ncbi Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus. Effect of omega-3 fatty acids
    Y Suresh
    EFA Sciences LLC, Norwood, Massachusetts 02062, USA
    Nutrition 19:213-28. 2003
    ..These results suggested that omega-3 fatty acids can abrogate chemically induced diabetes in experimental animals and attenuate the oxidant stress that occurs in diabetes mellitus...
  35. ncbi Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women
    Sheila M Innis
    Department of Pediatrics, University of British Columbia, Vancouver, Canada
    Am J Clin Nutr 77:473-8. 2003
    ..Little is known about n-3 fatty acid intakes in pregnant women, although human milk concentrations of DHA have decreased in recent years...
  36. ncbi Omega-3 fatty acids in inflammation and autoimmune diseases
    Artemis P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    J Am Coll Nutr 21:495-505. 2002
    ..Many of the placebo-controlled trials of fish oil in chronic inflammatory diseases reveal significant benefit, including decreased disease activity and a lowered use of anti-inflammatory drugs...
  37. ncbi Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, MA 02118, USA
    Am J Clin Nutr 77:819-25. 2003
    ..Dietary intake of linolenic acid is associated with a lower risk of cardiovascular disease mortality. However, it is unknown whether linolenic acid is associated with a lower risk of carotid atherosclerosis...
  38. ncbi Diet and gene expression: delta-5 and delta-6 desaturases in healthy Chinese and European subjects
    M Xiang
    Centre for Biosciences Research, School of Science, University of Greenwich, Kent, UK
    Ann Nutr Metab 50:492-8. 2006
    ..To compare the composition of fatty acids (FAs) in diet, and the expression of delta-6 desaturase (D6D) and delta-5 desaturase (D5D) genes in peripheral blood mononuclear cells (PBMCs) between Chinese and Europeans...
  39. ncbi Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects
    Yvonne E Finnegan
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, United Kingdom
    Am J Clin Nutr 77:783-95. 2003
    ....
  40. ncbi The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes
    Hsien Tsung Yao
    Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County, Taiwan, ROC
    Life Sci 79:2432-40. 2006
    ..These results indicate that the PUFAs are potent inhibitors as well as the substrates of CYP2C9 and CYP2C19...
  41. ncbi [Dietary fatty acids and experimental carcinogenesis]
    Philippe Bougnoux
    INSERM E 0211, Equipe de recherche Nutrition, Croissance et Cancer, CORAD, CHU de Tours 2, boulevard Tonnellé 37044 Tours Cedex
    Bull Cancer 92:685-96. 2005
    ..On the other hand, an excessive consumption of n-6 PUFAs and of saturated fatty acids could promote colon cancers...
  42. ncbi Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats
    Ameer Y Taha
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada M5S 3E2
    Metabolism 54:1127-32. 2005
    ..In the absence of sustained ketosis, changes in fatty acid metabolism resulting in an increase in brain polyunsaturates, particularly docosahexaenoic acid may, nevertheless, contribute to the seizure protection by the ketogenic diet...
  43. ncbi Polyunsaturated fatty acid (PUFA) changes in serum and liver of undernourished rats given dietary vitamin B6 supplementation
    Jerzy Bertrandt
    Military Institute of Hygiene and Epidemiology, 4 Kozielska Str, 01 163 Warsaw, Poland
    J Nutr Sci Vitaminol (Tokyo) 51:129-34. 2005
    ..Further limitation of this diet consumption to 30%, caused a significant decrease of LA and ALA and an increase of EPA content...
  44. ncbi Infants with intrauterine growth restriction have impaired formation of docosahexaenoic acid in early neonatal life: a stable isotope study
    Adolfo Llanos
    Institute of Nutrition and Food Technology, Santiago, Castilla, Chile
    Pediatr Res 58:735-40. 2005
    ..Similar evaluation for the n-6 series was not significant. DHA metabolism is affected in infants with IUGR; the restricted DPA to DHA conversion step seems to be principally responsible for this finding...
  45. ncbi Cholesterol and n-3 and n-6 fatty acid content in eggs from laying hens fed with red crab meal (Pleuroncodes planipes)
    S Carrillo-Domínguez
    Departamento de Nutricion Animal, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga Number 15, 14000 Mexico DF
    Poult Sci 84:167-72. 2005
    ..It was concluded that inclusion of red crab meal in laying hen rations at levels of 3 and 6% (P < 0.05) increased the n-3 and n-6 fatty acids content in eggs...
  46. ncbi Plant-based diet, serum fatty acid profile, and free radicals in postmenopausal women: the diet and androgens (DIANA) randomized trial
    C Colombo
    Hormone Research Laboratory, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Int J Biol Markers 20:169-76. 2005
    ..The results indicated that a plant-based diet can improve the serum fatty acid profile and decrease ROMs production. These results suggest that a plant-based diet may reduce the body's exposure to oxidative stress...
  47. ncbi Maternal dietary fat alters amniotic fluid and fetal intestinal membrane essential n-6 and n-3 fatty acids in the rat
    Russell Friesen
    Nutrition Research Program, Research Institute for Child and Family Health, 950 W 28th Ave, Vancouver, British Columbia, Canada V5Z 4H4
    Am J Physiol Gastrointest Liver Physiol 290:G505-10. 2006
    ..Maternal dietary fat can influence tissue composition by manipulation of amniotic fluid that is swallowed by the fetus or by transport across the placenta...
  48. ncbi Paradoxical effect of n-3-containing vegetable oils on long-chain n-3 fatty acids in rat heart
    Leslie G Cleland
    Hanson Institute and Rheumatology Unit, Royal Adelaide Hospital, SA, Australia
    Lipids 40:995-8. 2005
    ..e., flaxseed > echium > canola > sunflower oil. This paradox may be explained by lower ALA intake leading to decreased competition for Delta6 desaturase activity between ALA and the 24:5n-3 FA precursor to DHA formation...
  49. ncbi Phospholipid fatty acid composition and diamine oxidase activity of intestinal mucosa from rats treated with irinotecan hydrochloride (CPT-11) under vegetable oil-enriched diets: comparison between perilla oil and corn oil
    Makoto Usami
    Division of Surgical Metabolism, Faculty of Health Science, Kobe University School of Medicine, 7 10 2 Tomogaoka, Suma ku, Kobe 654 0142, Japan
    JPEN J Parenter Enteral Nutr 30:124-32. 2006
    ..The effect of dietary vegetable oil supplementation, perilla oil vs corn oil, was also evaluated...
  50. ncbi Docosahexaenoic acid in red blood cells of term infants receiving two levels of long-chain polyunsaturated fatty acids
    Dennis R Hoffman
    Retina Foundation of the Southwest, Dallas, Texas, USA
    J Pediatr Gastroenterol Nutr 42:287-92. 2006
    ....
  51. ncbi Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer
    Michael F Leitzmann
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Clin Nutr 80:204-16. 2004
    ..Laboratory studies have shown that n-3 fatty acids inhibit and n-6 fatty acids stimulate prostate tumor growth, but whether the dietary intake of these fatty acids affects prostate cancer risk in humans remains unclear...
  52. ncbi Dietary n-6 and n-3 fatty acid balance and cardiovascular health
    Vasuki Wijendran
    Foster Biomedical Research Lab, Brandeis University, Waltham, Massachusetts 02254, USA
    Annu Rev Nutr 24:597-615. 2004
    ..However, the absolute mass of essential fatty acids consumed, rather than their n-6/n-3 ratio, should be the first consideration when contemplating lifelong dietary habits affecting cardiovascular benefit from their intake...
  53. ncbi Effect of dietary fat sources and zinc and selenium supplements on the composition and consumer acceptability of chicken meat
    R Bou
    Nutrition and Food Science Department CeRTA, Faculty of Pharmacy, University of Barcelona, Avinguda Joan XXIII s n, E 08028 Barcelona, Spain
    Poult Sci 84:1129-40. 2005
    ..Consumer acceptability scores and TBA values of cooked dark chicken meat after 74 d or after 18 mo of frozen storage were not affected by any of the dietary factors studied...
  54. ncbi Effect of varying the ratio of n-6 to n-3 fatty acids by increasing the dietary intake of alpha-linolenic acid, eicosapentaenoic and docosahexaenoic acid, or both on fibrinogen and clotting factors VII and XII in persons aged 45-70 y: the OPTILIP study
    Thomas A B Sanders
    Nutritional Sciences Research Division, King s College London, London, United Kingdom
    Am J Clin Nutr 84:513-22. 2006
    ..This study tested the hypothesis that lowering the dietary ratio of n-6 to n-3 polyunsaturated fatty acids (n-6:n-3) would modify these risk factors in older men and women...
  55. ncbi Comparison of the fatty-acid compositions of prey items and yolks of Australian insectivorous scincid lizards
    Brian K Speake
    Avian Science Research Centre, SAC, KA6 5HW, Auchincruive, Ayr, UK
    J Comp Physiol B 174:393-7. 2004
    ..However, the docosahexaenoic acid of the egg lipids cannot derive from the diet and must, therefore, be formed by biosynthesis in the maternal liver, using dietary alpha-linolenic and eicosapentaenoic acids as precursors...
  56. ncbi Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males
    H Tavilani
    Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Science, Hamadan, Iran
    Andrologia 38:173-8. 2006
    ..001) respectively. This study demonstrates that spermatozoa of asthenozoospermic men have lower levels of PUFA compared with saturated fatty acids. This may be contributory to the poor motility noted in samples from these men...
  57. ncbi Seasonal and environmental effects on breast milk fatty acids in Burkina Faso and the need to improve the omega 3 PUFA content
    N Thiombiano-Coulibaly
    University of Ouagadougou, UFRSVT CRSBAN, Ouagadougou, Burkina Faso
    Acta Paediatr 92:1388-93. 2003
    ..To determine the Burkinabè breast milk lipid content and fatty acid composition and to compare these values with the recommended adequate intakes...
  58. ncbi [Dietary fatty acids and colorectal and prostate cancers: epidemiological studies]
    Pierre Astorg
    UMR Inserm 557 INRA CNAM Epidémiologie nutritionnelle, Institut scientifique et technique de l Alimentation, Conservatoire National des Arts et Metiers, 5 rue du Vertbois, 75003 Paris
    Bull Cancer 92:670-84. 2005
    ..This study reviews epidemiological works having studied the associations of dietary fatty acids, especially of n-6 or n-3 polyunsaturated fatty acids (PUFA), with the risks of colorectal and prostate cancers...
  59. ncbi Modulation of essential (n-6):(n-3) fatty acid ratios alters fatty acid status but not bone mass in piglets
    Hope A Weiler
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba R3T 2N2 Canada
    J Nutr 132:2667-72. 2002
    ..The results may be of relevance to the nutritional management of preterm infants whose DHA status is often too low and bone resorption too high...
  60. ncbi Low contribution of n-3 polyunsaturated fatty acids to plasma and erythrocyte membrane lipids in diabetic young adults
    T Decsi
    Department of Paediatrics, University of Pecs, József A u 7, H 7623 Pecs, Hungary
    Prostaglandins Leukot Essent Fatty Acids 76:159-64. 2007
    ..40, P<0.05) and sterol ester (r=-0.40, P<0.05) fractions. The data obtained in the present study suggest that the availability of n-3 long-chain polyunsaturated fatty acid may be reduced in young diabetic adults...
  61. ncbi Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum
    T Moriguchi
    Laboratory of Membrane Biochemistry and Biophysics, National Institutes on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 42:419-27. 2001
    ..Moriguchi, T., J. Loewke, M. Garrison, J. N. Catalan, N. Salem, Jr. Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum. J. Lipid Res. 2001. 42: 419--427...
  62. ncbi Dietary alpha-linolenic acid lowers postprandial lipid levels with increase of eicosapentaenoic and docosahexaenoic acid contents in rat hepatic membrane
    H K Kim
    Department of Food and Nutrition, Seoul National University, Korea
    Lipids 36:1331-6. 2001
    ..These results suggest that n-3 ALA has more of a hypolipidemic effect than n-6 LA and that the hypolipidemic effect of n-3 PUFA may be partly related to the increase of EPA and DHA in hepatic membrane...
  63. pmc Multi-targeted therapy of cancer by omega-3 fatty acids
    Isabelle M Berquin
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States
    Cancer Lett 269:363-77. 2008
    ..In this review, we discuss the rationale for using long-chain n-3 PUFAs in cancer prevention and treatment and the challenges that such approaches pose in the design of clinical trials...
  64. pmc Effect of dietary docosahexaenoic acid on biosynthesis of docosahexaenoic acid from alpha-linolenic acid in young rats
    James C DeMar
    Section of Nutritional Neurosciences, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 49:1963-80. 2008
    ..When preformed DHA was unavailable, d5-DHA and unlabeled DHA were preferentially accreted in some tissues along with a net loss of unlabeled DHA from other organs...
  65. ncbi Fatty acid content of plasma lipids and erythrocyte phospholipids are altered following burn injury
    V C Pratt
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada T6G 2P5
    Lipids 36:675-82. 2001
    ....
  66. ncbi Incorporation of alpha-linolenic acid and linoleic acid into human respiratory epithelial cell lines
    D L Bryan
    Department of Pediatrics, Flinders University, South Australia, Australia
    Lipids 36:713-7. 2001
    ....
  67. ncbi Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length
    S L Elias
    Department of Paediatrics, University of British Columbia, Vancouver, Canada
    Am J Clin Nutr 73:807-14. 2001
    ..33) and between TFA and AA concentrations in cholesteryl esters (r = -0.23). CONCLUSION: The results suggest possible important effects of TFAs and of AA on fetal growth and length of gestation...
  68. ncbi Long-chain polyunsaturated fatty acid concentrations in human hindmilk are constant throughout twelve months of lactation
    C Agostoni
    Department of Pediatrics, San Paolo Hospital, Milan, Italy
    Adv Exp Med Biol 501:157-61. 2001
    ..These data indicate that the secretion of arachidonic acid and docosahexaenoic acid during lactation remains constant, in spite of changes in total fat and in the linoleic acid and alpha-linolenic acid contents of milk...
  69. ncbi Fatty acid composition of the milk lipids of Nepalese women: correlation between fatty acid composition of serum phospholipids and melting point
    R H Glew
    Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Prostaglandins Leukot Essent Fatty Acids 65:147-56. 2001
    ....
  70. ncbi Short-term efficacy of enteral nutrition in the treatment of active Crohn's disease: a randomized, controlled trial comparing nutrient formulas
    Toshihiro Sakurai
    Department of Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino, Japan
    JPEN J Parenter Enteral Nutr 26:98-103. 2002
    ..We therefore performed a prospective, randomized, controlled study to compare the effects of nutrient formulas differing in the amount of medium-chain triglycerides (MCT)...
  71. pmc The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids
    Klara Kitajka
    Institute of Biochemistry, and DNA Chip Laboratory, Biological Research Center, Hungarian Academy of Sciences, P O Box 521, H 6701 Szeged, Hungary
    Proc Natl Acad Sci U S A 99:2619-24. 2002
    ....
  72. ncbi Decreasing linoleic acid with constant alpha-linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men
    Y Angela Liou
    The Nutrition Research Program, Child and Family Research Institute, University of British Columbia, Vancouver, Canada V52 4H40
    J Nutr 137:945-52. 2007
    ..In conclusion, high LA intakes decrease plasma phospholipid EPA and increase the ARA:EPA ratio, but do not favor higher ARA...
  73. pmc Omega-6 and omega-3 fatty acids predict accelerated decline of peripheral nerve function in older persons
    F Lauretani
    Tuscany Regional Health Agency, Florence, Italy
    Eur J Neurol 14:801-8. 2007
    ..Low plasma omega-6 and omega-3 fatty acids levels were associated with accelerated decline of peripheral nerve function with aging...
  74. ncbi Effects of dietary flaxseed oil supplementation on equine plasma fatty acid concentrations and whole blood platelet aggregation
    Rodney A Hansen
    Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA
    J Vet Intern Med 16:457-63. 2002
    ....
  75. ncbi A decrease in cell size accompanies a loss of docosahexaenoate in the rat hippocampus
    Aneeq Ahmad
    Section of Nutritional Neuroscience, Laboratory of Membrane Biochemistry and Biophysics, Division of Intramural Clinical and Biological Research, National Institutes on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
    Nutr Neurosci 5:103-13. 2002
    ..No differences were detected in any of these measures except for in cell body size; CA1 pyramidal neurons in the LA group were significantly (p < 0.04) smaller than neurons in the +LNA/DHA group at the septal location...
  76. ncbi Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions
    Jishen Pan
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, New York 10595, USA
    Chem Res Toxicol 15:367-72. 2002
    ..These results may be important for the understanding of the specific roles of different types of fatty acids in tumorigenesis...
  77. ncbi Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults
    F Thies
    Department of Biochemistry, University of Oxford, United Kingdom
    Lipids 36:1183-93. 2001
    ....
  78. ncbi Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y
    F Thies
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 73:539-48. 2001
    ..CONCLUSION: A moderate amount of EPA but not of other n-6 or n-3 polyunsaturated fatty acids can decrease NK cell activity in healthy subjects...
  79. ncbi Reversibility of n-3 fatty acid deficiency-induced alterations of learning behavior in the rat: level of n-6 fatty acids as another critical factor
    A Ikemoto
    Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori, Mizuhoku, Nagoya 467-8603, Japan
    J Lipid Res 42:1655-63. 2001
    ....
  80. ncbi Hot topic: Enhancing omega-3 fatty acids in milk fat of dairy cows by using stearidonic acid-enriched soybean oil from genetically modified soybeans
    G Bernal-Santos
    Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
    J Dairy Sci 93:32-7. 2010
    ....
  81. ncbi Effect of linseed oil supplementation on concentrations of (n-3) polyunsaturated fatty acids in liver phospholipids of rats fed diets containing either an oil rich in conjugated linoleic acids, sunflower oil or high-oleic acid sunflower oil
    K Eder
    Institute of Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Anim Physiol Anim Nutr (Berl) 89:45-54. 2005
    ..The results show that feeding the CLA oil reduced the formation of arachidonic acid and eicosanoids but enhanced the formation of long chain (n-3) PUFA and their incorporation into tissue lipids when compared with feeding SFO or HO-SFO...
  82. ncbi Investigation of gene expressions related to cholesterol metabolism in rats fed diets enriched in n-6 or n-3 fatty acid with a cholesterol after long-term feeding using quantitative-competitive RT-PCR analysis
    M Fukushima
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan
    J Nutr Sci Vitaminol (Tokyo) 47:228-35. 2001
    ....
  83. ncbi Molecular cloning and functional characterization of fatty acyl desaturase and elongase cDNAs involved in the production of eicosapentaenoic and docosahexaenoic acids from alpha-linolenic acid in Atlantic salmon (Salmo salar)
    Nicola Hastings
    Institute of Aquaculture, University of Stirling, FK9 4LA, Scotland, UK
    Mar Biotechnol (NY) 6:463-74. 2004
    ..Thus this one polypeptide product displays all fatty acid elongase activities required for the biosynthesis of docosahexaenoic acid (22:6n-3) from 18:3n-3...
  84. ncbi Where to find omega-3 fatty acids and how feeding animals with diet enriched in omega-3 fatty acids to increase nutritional value of derived products for human: what is actually useful ?
    J M Bourre
    Membre de l Academie de Medecine, INSERM Neuro pharmaco nutrition, Hopital Fernand Widal, 200 rue du Faubourg Saint Denis, 75745 Paris cedex 10 43 40
    J Nutr Health Aging 9:232-42. 2005
    ..8% daily energy intake in adult, 0.9 % in aged) and DHA is multiplied by 2 (0.05 % daily energy intake in adult, 0.1 % in aged; as well as in pregnant and lactating women)...
  85. ncbi Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age
    Ingrid B Helland
    Institute for Nutrition Research, University of Oslo, Oslo, Norway Peter Möller, avd Orkla, ASA, Oslo, Norway
    Pediatrics 111:e39-44. 2003
    ....
  86. ncbi Visual, cognitive, and language assessments at 39 months: a follow-up study of children fed formulas containing long-chain polyunsaturated fatty acids to 1 year of age
    Nancy Auestad
    Ross Products Division, Abbott Laboratories, Columbus, Ohio 43215, USA
    Pediatrics 112:e177-83. 2003
    ..The present follow-up study evaluated IQ, receptive and expressive vocabulary, visual-motor function, and visual acuity of children from the original trial when they reached 39 months of age...
  87. ncbi Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 2 : macronutrients
    J M Bourre
    French Academy of Medicine, Department of Neuro pharmaco nutrition INSERM, U705 CNRS, UMR 7157 Universites Paris 7 et 5 Hopital Fernand Widal, 200 rue du Faubourg Saint Denis 75745 Paris cedex 10
    J Nutr Health Aging 10:386-99. 2006
    ..Effects of micronutrients have been examined in the accompanying paper...
  88. ncbi Comparative effects of perilla and fish oils on the activity and gene expression of fatty acid oxidation enzymes in rat liver
    T Ide
    Laboratory of Nutrition Biochemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, 2 1 2 Kannondai, Tsukuba Science City, Japan
    Biochim Biophys Acta 1485:23-35. 2000
    ..Dietary perilla oil and fish oil therefore exert similar physiological activity in modulating hepatic fatty acid oxidation, but these dietary fats considerably differ in affecting fatty acid synthesis...
  89. ncbi Fatty acid alteration of plastidic and extra-plastidic membrane lipids in metribuzin-resistant photoautotrophic Chenopodium rubrum cells as compared to wild-type cells
    C Schwenger Erger
    , , , Germany
    Z Naturforsch C 56:1047-56. 2001
    ..g. linoleoyl moieties in L4 and L7 cells as well as linolenoyl moieties particularly in highly resistant L4 cells. This increase gives rise to a change in membrane fluidity and may finally lead to increased metribuzin resistance...
  90. pmc Insulin-tumour interrelationships in EL4-lymphoma or thymoma-bearing mice. II. Effects of dietary omega-3 and omega-6 polyunsaturated fatty acids
    D Yam
    Weizmann Institute of Science, Rehovot, Israel
    Br J Cancer 62:897-902. 1990
    ....
  91. ncbi Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing
    J M Bourre
    INSERM Research Director Unit U26 Neuro pharmaco nutrition Hopital Fernand Widal, 200 rue du Faubourg Saint Denis 75745 Paris cedex 10
    J Nutr Health Aging 8:163-74. 2004
    ..Peroxisomal oxidation of polyunsaturated fatty acids decreases in the brain during ageing, participating in decreased turnover of membrane fatty acids, which are also less effectively protected against peroxidation by free radicals...
  92. ncbi Adipose tissue fatty acids and risk of myocardial infarction--a case-control study
    J I Pedersen
    Institute for Nutrition Research, University of Oslo, Oslo, Norway
    Eur J Clin Nutr 54:618-25. 2000
    ..To study the association between content in adipose tissue of very long-chain n-3 fatty acids, trans fatty acids, linoleic acid and alpha-linolenic acid and risk of a first myocardial infarction...
  93. ncbi A defect in the activity of Delta6 and Delta5 desaturases may be a factor predisposing to the development of insulin resistance syndrome
    Undurti N Das
    UND Life Sciences, 1083 Main Street, Walpole, MA 02081, USA
    Prostaglandins Leukot Essent Fatty Acids 72:343-50. 2005
    ..Thus, calorie restriction or reduced food intake has a role not only in the pathobiology of insulin resistance, but also in other associated conditions such as obesity, type II diabetes mellitus, ageing, and longevity...
  94. ncbi Activity of hepatic fatty acid oxidation enzymes in rats fed alpha-linolenic acid
    Y Kabir
    Laboratory of Nutrition Biochemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Ibaraki, Japan
    Biochim Biophys Acta 1304:105-19. 1996
    ..Thus, compared to linoleic acid and saturated fatty acids, dietary alpha-18:3 caused characteristic changes in the activity of hepatic enzymes in fatty acid and glucose metabolism in rats...
  95. ncbi Effect of dietary alpha-linolenic acid on the activity and gene expression of hepatic fatty acid oxidation enzymes
    T Ide
    Laboratory of Nutrition Biochemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba, Japan
    Biofactors 13:9-14. 2000
    ..It was suggested that both substrate specificities and alterations in the activities of the enzymes in beta-oxidation pathway play a significant role in the regulation of the serum lipid concentrations in rats fed alpha-18:3...
  96. ncbi [The role of nutritional factors on the structure and function of the brain: an update on dietary requirements]
    J M Bourre
    Unité de recherches en Neuro Pharmaco Nutrition, INSERM U26, Hopital Fernand Widal, Paris
    Rev Neurol (Paris) 160:767-92. 2004
    ..Among various vitamin E components, only alpha-tocopherol is involved in nervous membranes. The objective of this update is to give an overview of the effects of dietary nutrients on the structure and certain functions of the brain...
  97. ncbi General characteristics of Pinus spp. seed fatty acid compositions, and importance of delta5-olefinic acids in the taxonomy and phylogeny of the genus
    R L Wolff
    ISTAB, Universite Bordeaux 1, Talence, France
    Lipids 35:1-22. 2000
    ..sylvestris), and the lowest level is 0.6% (P. monophylla). Uniting as well as discriminating features that may complement the knowledge about the taxonomy and phylogeny of pines are emphasized...
  98. ncbi Effects of diets enriched in n-6 or n-3 fatty acids on cholesterol metabolism in older rats chronically fed a cholesterol-enriched diet
    M Fukushima
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Lipids 36:261-6. 2001
    ....
  99. pmc Classical maple syrup urine disease and brain development: principles of management and formula design
    Kevin A Strauss
    Clinic for Special Children, Strasburg, PA 17579, USA
    Mol Genet Metab 99:333-45. 2010
    ....
  100. ncbi Interactions of dietary fats and proteins on fatty acid composition of immune cells and LTB4 production by peritoneal exudate cells of rats
    S Kaku
    Department of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Japan
    Biosci Biotechnol Biochem 65:315-21. 2001
    ..These suggest an anti-inflammatory property of gamma-linolenic acid as well as alpha-linolenic acid tended to be strengthened when they were combined with soybean protein than with casein...
  101. ncbi Straight-chain acyl-CoA oxidase knockout mouse accumulates extremely long chain fatty acids from alpha-linolenic acid: evidence for runaway carousel-type enzyme kinetics in peroxisomal beta-oxidation diseases
    Juan P Infante
    Institute for Theoretical Biochemistry and Molecular Biology, Ithaca, New York, 14852
    Mol Genet Metab 75:108-19. 2002
    ....

Research Grants55

  1. Gut mucosal mast cells are activated by fat absorption: physiology and mechanism
    Patrick Tso; Fiscal Year: 2013
    ..g. chylomicrons (CMs) or the media containing CMs by the intestinal epithelial cell line (Caco-2 cells) on RBC-2H3 cell NF-kB response. If the outcome is positive, we will isolate the factor/factors involved. ..
  2. Therapeutic Efficacy of Flaxseed in the Treatment of Ovarian Cancer
    Dale B Hales; Fiscal Year: 2013
    ....
  3. A study evaluating the effect of flaxseed on biomarkers of breast cancer risk
    Swati Kulkarni; Fiscal Year: 2010
    ..This study will determine if flaxseed can reduce the number of growing cells in the breast of young women who are at increased risk of developing breast cancer. ..
  4. Long-Term Dietary Risk Factor Assessment and Incident AD
    MARTHA MORRIS; Fiscal Year: 2009
    ..The proposed application should help to answer important scientific questions on the dietary prevention of a debilitating disease that affects a large number of older persons. ..
  5. Profiling Plasma Unbound Free Fatty Acids for Early Detection of Stroke
    ALAN MARC KLEINFELD; Fiscal Year: 2010
    ..The use of this test would potentially reduce neurological damage from ischemic stroke by reducing the time required to diagnose and treat stroke patients. ..
  6. Pilot Study on Mammary Expression of Novel Desaturases
    ALISON VAN EENENNAAM; Fiscal Year: 2005
    ....
  7. EFFECTS OF POLYUNSATURATED FATTY ACIDS ON MEGAKARYOCYTES
    PAUL SCHICK; Fiscal Year: 1991
    ..of the study are to determine the effects of omega 3 fatty acids, eicosapentaenoic and docosahexaenoic, and alpha linolenic acid, as well as the omega 6 fatty acids, linoleic and gamma linolenic acids on megakaryocytes...
  8. BIOMEDICAL (BASIC)
    MIKE REUTER; Fiscal Year: 2009
    ..abstract_text> ..
  9. Structural Biology of Eicosanoid Biosynthesis
    R Garavito; Fiscal Year: 2005
    ..Overexpression of rat prostacyclin synthase and divinylether synthase also make crystallographic studies on these two membrane-bound P450 enzymes tractable. ..
  10. Flax: Safety & Efficacy in Reducing Cardiovascular Risk
    Philippe Szapary; Fiscal Year: 2003
    ..abstract_text> ..
  11. Brain DHA, Dopamine, and Behavior: Roles in ADHD
    Beth Levant; Fiscal Year: 2006
    ..Such insights may identify a means by which certain risk factors for ADHD may be reduced or eliminated or the severity of the disease may be reduced through appropriate pre- and postnatal nutrition. [unreadable] [unreadable]..
  12. Brain LC-PUFAs and Maternal Mental Health
    Beth Levant; Fiscal Year: 2006
    ..These findings will also suggest novel treatments for such illnesses when they occur. ..
  13. Brain Fatty Acid Composition and PKC Activity
    Robert McNamara; Fiscal Year: 2007
    ..The proposed experiments are innovative and exploratory in that the effect of altered DHA concentrations on PKC and dopamine D2 receptor expression have not been systematically examined in brain. [unreadable] [unreadable] [unreadable]..
  14. Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia
    Robert McNamara; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  15. Gene-Environment Interactions in Obesity and Diabetes
    Tracy Nelson; Fiscal Year: 2007
    ..Environment: Dr. Nelson will have an outstanding environment in which to carry out the proposed study, as well as, the necessary resources and support to successfully complete her training. ..
  16. Niacin, n-3 fatty acids and insulin resistance
    William Harris; Fiscal Year: 2007
    ..This should lead to more effective therapy for the dyslipidemia of insulin resistance and ultimately to reduced risk for CHD in this burgeoning patient population. ..
  17. LCPUFA Status and Birth Outcome in India
    JAMES BRENNA; Fiscal Year: 2007
    ..Positive results would justify an intervention studies to include LCPUFA in the diets of pregnant women in developed and developing countries. ..
  18. Lipidomics Session ISSFAL 2006
    JAMES BRENNA; Fiscal Year: 2006
    ..ISSFAL 2006 is expected to be among the most important international lipid metabolism conferences of the year, and a lipidomics symposium is timely given the increasing progress in this area. [unreadable] [unreadable] [unreadable]..
  19. Gas phase derivatization for lipidomic MS analysis
    JAMES BRENNA; Fiscal Year: 2007
    ....
  20. BIOCHEMICAL CHARACTERIZATION OF PPAR
    JOHN VANDEN HEUVEL; Fiscal Year: 2008
    ..Taken together the proposed studies will greatly enhance our knowledge of PPARalpha's mechanism of action and hence our understanding of an important class of carcinogen. ..
  21. DIETARY FATTY ACIDS, PPAR ACTIVATED GENES, AND CHD
    HANNAI CAMPOS; Fiscal Year: 2005
    ..Because polyunsaturated FAs are important as activators of PPARs and their capacity to regulate gene expression at the level of transcription, this metabolic system is a suitable candidate for the proposed study. ..
  22. DIETARY ESSENTIAL FATTY ACID ACCUMULATION IN RETINA
    JAMES BRENNA; Fiscal Year: 2002
    ..Sub-normal development will be directly revealed via functional tests to assess the impact of low omega-3 fatty acid status on develop of vision acid status on development of vision and related health parameters. ..
  23. Identification of biomarkers of fatty acid intake
    Hannia Campos; Fiscal Year: 2002
    ..abstract_text> ..
  24. PRECISE ISOTOPE RATIO CHROMATOGRAPHY AND STABLE TRACERS
    JAMES BRENNA; Fiscal Year: 2004
    ..The successful accomplishment of these plans will yield new tools and experimental approaches for investigation of the impact of developmental factors and recent physiological history on development of chronic disease. ..
  25. GENE-DIET INTERACTIONS AND HEART DISEASE
    HANNAI CAMPOS; Fiscal Year: 2003
    ..This study will provide the most complete data set to study numerous hypotheses relating genes, diet, and CHD, and could lead to specific targeted interventions for reducing the development of CHD. ..
  26. Amino Acids, Protein, and BMI in Adults Across Cultures
    Ka He; Fiscal Year: 2008
    ..It is of great public health and clinical significance as obesity is a major health concern. The findings from this project may lead to new research on obesity prevention. [unreadable] [unreadable] [unreadable] [unreadable]..
  27. Trace Elements and Cardiovascular Disease (CVD) Risks Factors Among Young Adults
    Ka He; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. RESEARCH TRAINING IN MATERNAL, INFANT & CHILD NUTRITION
    William Heird; Fiscal Year: 2008
    ..abstract_text> ..
  29. TRIGGERS OF VENTRICULAR ARRHYTHMIAS (TOVA) STUDY
    Christine Albert; Fiscal Year: 2002
    ..Characterization of triggering of ICD discharge will provide insights valuable for prevention of sudden death due to primary arrhythmias in the general population. ..
  30. Genetic modification of PUFA biosynthesis and CHD
    Ana Baylin; Fiscal Year: 2008
    ..This strengthens evaluation of risk, and application to current dietary goals. The large number of SNPs proposed for final analysis will add to the resolution and power to identify the genes that underlie CHD. ..
  31. Male Reproductive Effects from Exposure to Boron
    Wendie Robbins; Fiscal Year: 2005
    ....
  32. Metabolic and Epidemiologic Evaluation of Choline and Betaine Intake
    Eunyoung Cho; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. Omega-3 fat to reduce risk for breast cancer
    WANDA ELAINE HARDMAN; Fiscal Year: 2010
    ....
  34. HOW DIETARY N-3 FATTY ACIDS PREVENT FATAL ARRHYTHMIAS
    Alexander Leaf; Fiscal Year: 2001
    ..abstract_text> ..
  35. CHOLESTEROL REDUCTION EFFECTS ON BEHAVIOR
    Matthew Muldoon; Fiscal Year: 2001
    ..The use of two treatment intensities will permit examination of the dose-response relationship between the degree of cholesterol lowering and cognitive performance. ..
  36. DIETARY OMEGA-3 FATTY ACIDS, GENE EXPRESSION AND GROWTH
    William Heird; Fiscal Year: 2001
    ..abstract_text> ..
  37. DIET, AROMATIC AMINO ACIDS, AND CNS NEUROTRANSMITTERS
    John Fernstrom; Fiscal Year: 2001
    ..Our data will also add important new information on the relative roles of TYR and PHE as substrates in CAM synthesis, and the impact of diet on CAM synthesis, acting via changes it produces in the neuronal pools of each substrate. ..
  38. Low Cost Production of the Malaria Drug Artemether
    Brooks Hybertson; Fiscal Year: 2007
    ..This project seeks to develop, validate, and commercialize a new, cheaper method for producing the highly effective malaria drug artemether from the Sweet Wormwood plant. [unreadable] [unreadable] [unreadable]..
  39. MODIFIABLE RISK FACTORS FOR SUDDEN DEATH IN MEN/WOMEN
    Christine Albert; Fiscal Year: 2002
    ..At the end of the proposed research program, Dr. Albert will have attained advanced epidemiologic skills which can then be applied to independent research in her chosen subspecialty of electrophysiology. ..
  40. Impact of Development on Protein Utilization and Growth
    William Heird; Fiscal Year: 2007
    ..Overall, the findings of this project are expected to contribute to further improvements in nutritional management and, hence, outcome of LBW infants. ..
  41. Animal Models of Diabetic Vascular Disease
    Jan Breslow; Fiscal Year: 2005
    ..We will then use new genetic technology to combine the various required alleles to make a diabetogenic- macrovascular disease model that is easy to breed and transfer to other investigators. ..
  42. Biochemical and Metabolic Properties of 10-HETE
    ARTHUR SPECTOR; Fiscal Year: 2006
    ..The ultimate goal of this project is to provide the additional mechanistic insight necessary to develop new therapeutic approaches to overcome the pathological actions of 20-HETE. ..
  43. Genetic Determinants of Sudden Cardiac Death
    Christine Albert; Fiscal Year: 2006
    ..The findings generated will have substantial implications for our understanding of the SCD syndrome and risk stratification in the general population. ..
  44. Gene-diet interactions and dietary cholesterol response
    Jan Breslow; Fiscal Year: 2005
    ..of additional novel dietary cholesterol regulated genes and other genes determining differences in cholesterol metabolism and diet response between the sexes will be performed utilizing oligonucleotide microarrays, ..
  45. Evaluation of Biological Relevance of Choline Intake
    Eunyoung Cho; Fiscal Year: 2005
    ..The results from the proposed grant will enhance understanding of the role of choline intake in humans and lay the groundwork for future studies on choline intake and overall methyl-group-deficient diet and cancer. ..
  46. Modeling Antipsychotic-Induced Weight Gain in Rats
    John Fernstrom; Fiscal Year: 2005
    ..abstract_text> ..
  47. Respirable ciprofloxacin aerosol for inhaled anthrax
    Brooks Hybertson; Fiscal Year: 2004
    ..Our overall goal is to create a new tool for targeted treatment or prophylaxis for victims of anthrax spore inhalation. ..
  48. Walnuts vs. Walnut-Oil, Glucose Homeostasis, PCOS
    Sidika Kasim Karakas; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  49. Integration of Stress and Reproductive Axes by Dopamine
    Simon Evans; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  50. Distress, Fish Oil, Inflammation, and Heart Disease
    Matthew Muldoon; Fiscal Year: 2006
    ..Results of the study could redirect current conceptualizations of the relationship between psychological factors and CHD risk, and lead to randomized clinical trials testing new interventions. ..
  51. Modifiable Determinants of Ventricular Arrythmias
    Christine Albert; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  52. Nutrition Program-Caribbean Hispanic elders & diabetes
    ODILIA BERMUDEZ; Fiscal Year: 2003
    ....
  53. Fatty Acids and Cardiovascular Health
    Dariush Mozaffarian; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  54. Role of the 5-Lipoxygenase Pathway in Atherosclerosis
    Hooman Allayee; Fiscal Year: 2009
    ....