omega 6 fatty acids

Summary

Summary: FATTY ACIDS which have the first unsaturated bond in the sixth position from the omega carbon. A typical American diet tends to contain substantially more omega-6 than OMEGA-3 FATTY ACIDS.

Top Publications

  1. ncbi The importance of the ratio of omega-6/omega-3 essential fatty acids
    A P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    Biomed Pharmacother 56:365-79. 2002
  2. ncbi Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids
    Jing X Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 427:504. 2004
  3. ncbi The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder
    Alexandra J Richardson
    University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, United Kingdom
    Pediatrics 115:1360-6. 2005
  4. ncbi Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children
    Jan Philipp Schuchardt
    Institute of Food Science, Nutrition Physiology and Human Nutrition Unit, Leibniz University of Hanover, Am Kleinen Felde 30, 30167 Hanover, Germany
    Eur J Pediatr 169:149-64. 2010
  5. ncbi n-3 fatty acids, inflammation, and immunity--relevance to postsurgical and critically ill patients
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, United Kingdom
    Lipids 39:1147-61. 2004
  6. ncbi The opposing effects of n-3 and n-6 fatty acids
    Gerd Schmitz
    Institute of Clinical Chemistry, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Prog Lipid Res 47:147-55. 2008
  7. ncbi Fatty acids and postprandial inflammation
    Andrew N Margioris
    Department of Clinical Chemistry, School of Medicine, University of Crete, Crete, Greece
    Curr Opin Clin Nutr Metab Care 12:129-37. 2009
  8. ncbi Dietary (n-3)/(n-6) fatty acid ratio: possible relationship to premenopausal but not postmenopausal breast cancer risk in U.S. women
    Shelley L Goodstine
    Yale University School of Medicine and Yale Cancer Center, New Haven, CT, USA
    J Nutr 133:1409-14. 2003
  9. ncbi Very low n-3 long-chain polyunsaturated fatty acid status in Austrian vegetarians and vegans
    Margit Kornsteiner
    Department of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Vienna, Austria
    Ann Nutr Metab 52:37-47. 2008
  10. ncbi Dietary modeling shows that the substitution of canola oil for fats commonly used in the United States would increase compliance with dietary recommendations for fatty acids
    Guy H Johnson
    Department of Food Science and Human Nutrition, The University of Illinois, Urbana Champaign, USA
    J Am Diet Assoc 107:1726-34. 2007

Detail Information

Publications214 found, 100 shown here

  1. ncbi The importance of the ratio of omega-6/omega-3 essential fatty acids
    A P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    Biomed Pharmacother 56:365-79. 2002
    ....
  2. ncbi Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids
    Jing X Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 427:504. 2004
    ..As well as presenting an opportunity to investigate the roles played by n-3 fatty acids in the body, our discovery indicates that this technology might be adapted to enrich n-3 fatty acids in animal products such as meat, milk and eggs...
  3. ncbi The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder
    Alexandra J Richardson
    University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, United Kingdom
    Pediatrics 115:1360-6. 2005
    ..Given the current lack of effective, evidence-based treatment options for DCD, the use of fatty acid supplements merits investigation...
  4. ncbi Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children
    Jan Philipp Schuchardt
    Institute of Food Science, Nutrition Physiology and Human Nutrition Unit, Leibniz University of Hanover, Am Kleinen Felde 30, 30167 Hanover, Germany
    Eur J Pediatr 169:149-64. 2010
    ..Meanwhile, several controlled studies investigated the clinical benefits of LC-PUFA supplementation in affected children and adolescents, with occasionally conflicting results...
  5. ncbi n-3 fatty acids, inflammation, and immunity--relevance to postsurgical and critically ill patients
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, United Kingdom
    Lipids 39:1147-61. 2004
    ..Studies to date are suggestive of clinical benefits from these approaches, especially in postsurgical patients...
  6. ncbi The opposing effects of n-3 and n-6 fatty acids
    Gerd Schmitz
    Institute of Clinical Chemistry, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Prog Lipid Res 47:147-55. 2008
    ..In addition, the n-3/n-6 PUFA content of cell and organelle membranes, as well as membrane microdomains strongly influences membrane function and numerous cellular processes such as cell death and survival...
  7. ncbi Fatty acids and postprandial inflammation
    Andrew N Margioris
    Department of Clinical Chemistry, School of Medicine, University of Crete, Crete, Greece
    Curr Opin Clin Nutr Metab Care 12:129-37. 2009
    ..Purpose of this review is to describe this exciting new area of research and its repercussions in the way we, the consumers, and the food industry evaluate the type and quantity of fat in food...
  8. ncbi Dietary (n-3)/(n-6) fatty acid ratio: possible relationship to premenopausal but not postmenopausal breast cancer risk in U.S. women
    Shelley L Goodstine
    Yale University School of Medicine and Yale Cancer Center, New Haven, CT, USA
    J Nutr 133:1409-14. 2003
    ..50, 95% CI 0.27, 0.95, P for trend = 0.02. These results are consistent with the hypothesis that a higher (n-3)/(n-6) PUFA ratio may reduce the risk of breast cancer, especially in premenopausal women...
  9. ncbi Very low n-3 long-chain polyunsaturated fatty acid status in Austrian vegetarians and vegans
    Margit Kornsteiner
    Department of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Vienna, Austria
    Ann Nutr Metab 52:37-47. 2008
    ....
  10. ncbi Dietary modeling shows that the substitution of canola oil for fats commonly used in the United States would increase compliance with dietary recommendations for fatty acids
    Guy H Johnson
    Department of Food Science and Human Nutrition, The University of Illinois, Urbana Champaign, USA
    J Am Diet Assoc 107:1726-34. 2007
    ..To examine the effect of substituting canola oil for selected vegetable oils and canola oil-based margarine for other spreads on energy, fatty acid, and cholesterol intakes among US adults...
  11. ncbi Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer
    Michael F Leitzmann
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Clin Nutr 80:204-16. 2004
    ..Laboratory studies have shown that n-3 fatty acids inhibit and n-6 fatty acids stimulate prostate tumor growth, but whether the dietary intake of these fatty acids affects prostate cancer risk in humans remains unclear...
  12. ncbi Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial
    Frank Thies
    Institute of Human Nutrition, University of Southampton, Basset Crescent East, Southampton, UK
    Lancet 361:477-85. 2003
    ..We aimed to assess the hypothesis that incorporation of n-3 and n-6 PUFAs into advanced atherosclerotic plaques increases and decreases plaque stability, respectively...
  13. ncbi The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases
    Artemis P Simopoulos
    The Center for Genetics, Nutrition and Health, 2001 S Street, NW, Suite 530, Washington, DC 20009, USA
    Exp Biol Med (Maywood) 233:674-88. 2008
    ..A lower ratio of omega-6/omega-3 fatty acids is more desirable in reducing the risk of many of the chronic diseases of high prevalence in Western societies, as well as in the developing countries...
  14. pmc Promotion of prostatic metastatic migration towards human bone marrow stoma by Omega 6 and its inhibition by Omega 3 PUFAs
    M D Brown
    ProMPT Genito Urinary Cancer Research Group, Cancer Research UK
    Br J Cancer 94:842-53. 2006
    ..These results identify a mechanism by which arachidonic acid may potentiate the risk of metastatic migration and secondary implantation in vivo, a risk which can be reduced with the uptake of Omega-3 poly-unsaturated fatty acids...
  15. ncbi Omega-3 fatty acids in inflammation and autoimmune diseases
    Artemis P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    J Am Coll Nutr 21:495-505. 2002
    ..Many of the placebo-controlled trials of fish oil in chronic inflammatory diseases reveal significant benefit, including decreased disease activity and a lowered use of anti-inflammatory drugs...
  16. ncbi Dietary intakes and food sources of n-6 and n-3 PUFA in French adult men and women
    Pierre Astorg
    UMR Inserm 557 INRA CNAM Epidémiologie nutritionnelle, Institut Scientifique et Technique de la Nutrition et de I Alimentatio, Conservatoire National des Arts et Metiers, Paris, France
    Lipids 39:527-35. 2004
    ..Fish and seafood consumption showed very large interindividual variations, the low consumers being at risk of insufficient n-3 PUFA intake...
  17. ncbi Polyunsaturated fatty acids and inflammatory diseases
    A Gil
    Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Granada, Spain
    Biomed Pharmacother 56:388-96. 2002
    ..Moreover, the defence antioxidant system in this model is enhanced in treated animals, provided that the n-3 PUFA supply is adequately preserved from oxidation...
  18. ncbi Essential fatty acids and the brain
    Marianne Haag
    Department of Physiology, University of Pretoria, PO Box 2034, Pretoria 0001, South Africa
    Can J Psychiatry 48:195-203. 2003
    ..To review the role of essential fatty acids in brain membrane function and in the genesis of psychiatric disease...
  19. ncbi N-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, United Kingdom
    Lipids 38:343-52. 2003
    ..There are indications that the inclusion of fish oil in enteral and parenteral formulae is beneficial to patients...
  20. ncbi N-3 and N-6 fatty acids in breast adipose tissue and relative risk of breast cancer in a case-control study in Tours, France
    Virginie Maillard
    Laboratoire de Biologie des Tumeurs, Clinique d Oncologie Radiothérapie, Service de Gynecologie Obstetrique, E A 2103, Unité de Recherche Associée Université INRA, CHU, Tours, France
    Int J Cancer 98:78-83. 2002
    ....
  21. ncbi Dietary omega-3 fatty acids may be associated with increased neuropathic pain in nerve-injured rats
    Jordi Perez
    Anesthesia Research Unit, Pain Centre, Department of Anesthesia, McGill University Health Centre, Montreal, Canada
    Anesth Analg 101:444-8, table of contents. 2005
    ..006). We conclude that dietary oil might predict levels of neuropathic pain in rats and that this effect may be associated with dietary omega-3 levels...
  22. ncbi Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells
    A Vecchini
    Department of Internal Medicine, Section of Biochemistry, University of Perugia, Perugia, Italy
    J Lipid Res 45:308-16. 2004
    ..Conversely, it was observed that apoptosis induced by the alpha-linolenic acid-enriched diet correlated with a decrease in arachidonate content in hepatoma cells and decreased cyclooxygenase-2 expression...
  23. ncbi Eicosapentaenoic acid and arachidonic acid: collaboration and not antagonism is the key to biological understanding
    D F Horrobin
    Laxdale Ltd, King Park House, LaurelhiIl Business Park, Stirling FK7 9JQ, Scotland
    Prostaglandins Leukot Essent Fatty Acids 66:83-90. 2002
    ..We suggest that elevation of concentrations of both AA and EPA in cell membranes may be important for health...
  24. ncbi Opposing effects of n-6 and n-3 polyunsaturated fatty acids on pancreatic cancer growth
    Hitoshi Funahashi
    Hirshberg Laboratories for Pancreatic Cancer Research, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Pancreas 36:353-62. 2008
    ..The aim of this study was to evaluate the effects of n-6 and n-3 PUFAs on the growth of pancreatic cancer...
  25. ncbi Modulation of human immune and inflammatory responses by dietary fatty acids
    D S Kelley
    Western Human Nutrition Research Center, ARS USDA, and the Department of Nutrition, University of California at Davis, Davis, California, USA
    Nutrition 17:669-73. 2001
    ..The potential for the use of fish oils in the management of these diseases is tremendous, even though further studies are needed to establish safe and adequate intake levels of omega-3 fatty acids...
  26. ncbi Dietary intakes and food sources of fatty acids for Belgian women, focused on n-6 and n-3 polyunsaturated fatty acids
    Isabelle A Sioen
    Department of Public Health, Ghent University, Ghent, Belgium
    Lipids 41:415-22. 2006
    ..The main sources of long-chain PUFA were fish and seafood, and meat, poultry, and eggs. From a public health perspective, it seems desirable to tackle the problem of low n-3 PUFA intake...
  27. pmc Comparison of the effects of dietary n-3 and n-6 polyunsaturated fatty acids on very-low-density lipoprotein secretion when delivered to hepatocytes in chylomicron remnants
    X Zheng
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College St, London NW1 0TU, UK
    Biochem J 357:481-7. 2001
    ....
  28. ncbi Contribution of meat fat to dietary arachidonic acid
    D Li
    Department of Food Science, RMIT University, Melbourne, Vic, Australia
    Lipids 33:437-40. 1998
    ..The present data indicate that the visible meat fat can make a contribution to dietary intake of AA, particularly for consumers with high intakes of fat from pork or poultry meat...
  29. ncbi Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: a randomized placebo-controlled trial in children and adolescents
    Mats Johnson
    Department of Child and Adolescent Psychiatry, Goteborg University, Goteborg, Sweden
    J Atten Disord 12:394-401. 2009
    ..The aim of the study was to assess omega 3/6 fatty acids (eye q) in attention deficit hyperactivity disorder (ADHD)...
  30. ncbi Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3 beta phosphorylation
    Yi Lu
    Department of Medicine, University of Pittsburgh, VA Pittsburgh Healthcare Systems, Room 2E146, University Drive, Pittsburgh, PA 15240, USA
    Mol Cancer Ther 7:3203-11. 2008
    ..These results suggest that fat-1 gene transfer directly into tumor cells could be used as a novel therapeutic approach...
  31. ncbi Importance of the ratio of omega-6/omega-3 essential fatty acids: evolutionary aspects
    A P Simopoulos
    Center for Genetics, Nutrition and Health, Washington, D C, USA
    World Rev Nutr Diet 92:1-22. 2003
  32. ncbi Dietary fatty acid profile affects endurance in rats
    K J Ayre
    Department of Biological Sciences, University of Wollongong, N S W, Australia
    Lipids 32:1265-70. 1997
    ..005). Although n-3 fats are considered beneficial for cardiovascular health, they appear to reduce endurance times, and their side effects need to be further investigated...
  33. ncbi [The treatment of Attention-Deficit/Hyperactivity Disorders with polyunsaturated fatty acids - an effective treatment alternative?]
    Jan Frölich
    Klinik und Poliklinik für Psychiatrie und Psychotherapie des Kindes und Jugendalters der Universität zu Köln
    Z Kinder Jugendpsychiatr Psychother 36:109-16. 2008
    ..Preliminary study result suggest that dietary supplementation with LC-PUFA might be effective in the treatment of ADHD...
  34. ncbi Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes
    Jill M Norris
    Department of Preventive Medicine and Biostatistics, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    JAMA 298:1420-8. 2007
    ..Cod liver oil supplements in infancy have been associated with a decreased risk of type 1 diabetes mellitus in a retrospective study...
  35. ncbi Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation
    Sihem Madani
    Unitè Propre de Recherche de l Enseignement Supérieur Lipides, Universite de Bourgogne, Faculte des Sciences, 6 Boulevard Gabriel, F 21000 Dijon, France
    J Biol Chem 279:1176-83. 2004
    ..Our study demonstrates that three DAG molecular species bind to RasGRP, but only DAG-AA and DAG-DHA participate in the modulation of RasGRP-mediated activation of MAP kinases in Jurkat T cells...
  36. ncbi n-3 fatty acids in the treatment of diabetic patients: biological rationale and clinical data
    Raffaele De Caterina
    Institute of Cardiology, G D Annunzio University, Chieti, Italy
    Diabetes Care 30:1012-26. 2007
  37. pmc Omega 3 but not omega 6 fatty acids inhibit AP-1 activity and cell transformation in JB6 cells
    G Liu
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Proc Natl Acad Sci U S A 98:7510-5. 2001
    ..Similarly, because AA abrogates the beneficial effects of DHA, the dietary ratio of omega6 to omega3 fatty acids may be a significant factor in mediating tumor development...
  38. ncbi Types of dietary fat and risk of coronary heart disease: a critical review
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Am Coll Nutr 20:5-19. 2001
    ..We also discuss the implications of the available evidence in the context of current dietary recommendations...
  39. ncbi Reduced joint pain after short-term duodenal administration of seal oil in patients with inflammatory bowel disease: comparison with soy oil
    T Bjørkkjaer
    National Institute of Nutrition and Seafood Research, Bergen, Norway
    Scand J Gastroenterol 39:1088-94. 2004
    ....
  40. ncbi What is so special about the diet of Greece? The scientific evidence
    Artemis P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    World Rev Nutr Diet 95:80-92. 2005
  41. ncbi The importance of omega-6/omega-3 fatty acid ratio in cell function. The gene transfer of omega-3 fatty acid desaturase
    Jing X Kang
    Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
    World Rev Nutr Diet 92:23-36. 2003
  42. ncbi High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism
    Sarah M Conklin
    Department of Psychology, Allegheny College, 520 North Main Street, Meadville, PA 16335 3902, USA
    Psychosom Med 69:932-4. 2007
    ..Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults...
  43. ncbi Suicide attempt and n-3 fatty acid levels in red blood cells: a case control study in China
    Mingming Huan
    Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama City, Japan
    Biol Psychiatry 56:490-6. 2004
    ..Epidemiologic studies show that low fish intake is a risk factor of suicidality; however, there are no case-control studies investigating suicide attempt risk and tissue n-3 fatty acid levels...
  44. ncbi [The influence of the dietary polyunsaturated fatty acids on the phagocyte's functional activity in rats]
    E N Trushina
    Vopr Pitan 72:9-11. 2003
    ..0 was noted. The increased activity of mononuclear-phagocytic system was confirmed by morphological investigation of peripheral lymphoid organs...
  45. ncbi [Dietary fatty acids and experimental carcinogenesis]
    Philippe Bougnoux
    INSERM E 0211, Equipe de recherche Nutrition, Croissance et Cancer, CORAD, CHU de Tours 2, boulevard Tonnellé 37044 Tours Cedex
    Bull Cancer 92:685-96. 2005
    ..On the other hand, an excessive consumption of n-6 PUFAs and of saturated fatty acids could promote colon cancers...
  46. ncbi Transfer of n-3 and n-6 polyunsaturated fatty acids from yolk to embryo during development of the king penguin
    F Decrock
    , Centre National de la Recherche Scientifique, , 67087 Strasbourg, France
    Am J Physiol Regul Integr Comp Physiol 280:R843-53. 2001
    ..Thus both 22:6(n-3) and 20:4(n-6), which are, respectively, abundant and deficient in the yolk, undergo biomagnification during transfer to the embryo...
  47. ncbi Long-term supplementation of various dietary lipids alters bone mineral content, mechanical properties and histological characteristics of Japanese quail
    D Liu
    Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Poult Sci 82:831-9. 2003
    ..These results suggest that long-term exposure to a FO or HSBO diet have a significant beneficial effect on bone metabolism...
  48. ncbi Fatty acid composition of the milk lipids of Nepalese women: correlation between fatty acid composition of serum phospholipids and melting point
    R H Glew
    Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Prostaglandins Leukot Essent Fatty Acids 65:147-56. 2001
    ....
  49. ncbi Effect of dietary polyunsaturated fatty acids on uterine prostaglandin synthesis in the cow
    Z Cheng
    Reproduction and Development Group, Department of Veterinary Basic Sciences, Royal Veterinary College, Boltons Park, Hawkshead Road, Potters Bar, Hertfordshire EN6 1NB, UK
    J Endocrinol 171:463-73. 2001
    ..These data suggest that a high n-6 diet reduces the endometrial capacity to produce PGs and may therefore have implications for the control of luteolysis and other PG-mediated events such as ovulation...
  50. ncbi Diet and asthma: has the role of dietary lipids been overlooked in the management of asthma?
    Sheldon L Spector
    University of California Los Angeles, Los Angeles, California, USA
    Ann Allergy Asthma Immunol 90:371-7; quiz 377-8, 421. 2003
    ..Readers will gain an understanding of how evolution of the western diet has contributed to increased asthma prevalence and how dietary modification that includes management of dietary lipids may reduce symptoms of asthma...
  51. ncbi Paradoxical effect of n-3-containing vegetable oils on long-chain n-3 fatty acids in rat heart
    Leslie G Cleland
    Hanson Institute and Rheumatology Unit, Royal Adelaide Hospital, SA, Australia
    Lipids 40:995-8. 2005
    ..e., flaxseed > echium > canola > sunflower oil. This paradox may be explained by lower ALA intake leading to decreased competition for Delta6 desaturase activity between ALA and the 24:5n-3 FA precursor to DHA formation...
  52. ncbi Effect of dietary fat sources on systemic and intrauterine synthesis of prostaglandins during early pregnancy in gilts
    R Chartrand
    Departement des Sciences Animales, Faculté des sciences de l agriculture et de l alimentation, Universite Laval, Ste Foy, Quebec, Canada, G1K 7P4
    J Anim Sci 81:726-34. 2003
    ..Dietary enrichment in C18:2n-6 and/or C18:3n-3 for early pregnant gilts can influence fatty acids in plasma and endometrial tissue and can modulate circulatory and intrauterine prostaglandins...
  53. ncbi Biomarkers of fat and fatty acid intake
    Lenore Arab
    University of North Carolina School of Public Health, Chapel Hill, NC 27955, USA
    J Nutr 133:925S-932S. 2003
    ..e., alcohol consumption and smoking), circulating apolipoprotein levels and the hormonal milieu of the individual and the source tissue...
  54. ncbi Pilot study of dietary fatty acid supplementation in the treatment of adult periodontitis
    Elliot D Rosenstein
    Arthritis and Rheumatic Disease Center, St Barnabas Medical Center, 200 South Orange Avenue, Livingston, NJ 07039, USA
    Prostaglandins Leukot Essent Fatty Acids 68:213-8. 2003
    ..Additional studies will be necessary to more fully assess the potential of these agents to favorably affect periodontal inflammation...
  55. ncbi Polyunsaturated fatty acids and conjugated linoleic acid isomers in breast milk are associated with plasma non-esterified and erythrocyte membrane fatty acid composition in lactating women
    Alexandre G Torres
    Laboratorio de Bioquimica Nutricional e de Alimentos, Instituto de Quimica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Brazil
    Br J Nutr 95:517-24. 2006
    ..These findings emphasize the contribution of the NEFA pool derived from the adipose tissue to the long-chain fatty acid composition of breast milk...
  56. ncbi Polyunsaturated fatty acid deficiency during dietary treatment of very long-chain acyl-CoA dehydrogenase deficiency. Rescue with soybean oil
    J I Ruiz-Sanz
    Paediatrics Department, University Cruces Hospital, Cruces-Baracaldo, Spain
    J Inherit Metab Dis 24:493-503. 2001
    ..We wish to remark on this early complication in the nutritional management of VLCAD deficiency and the possibility of rescue by the incorporation of soybean oil into the diet...
  57. ncbi Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil
    J H Song
    Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, 981-8555, Sendai, Japan
    Atherosclerosis 155:9-18. 2001
    ....
  58. ncbi Role of weight loss and polyunsaturated fatty acids in improving metabolic fitness in moderately obese, moderately hypertensive subjects
    A D Kriketos
    Center for Human Nutrition, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Hypertens 19:1745-54. 2001
    ..The type of fat consumed had minor differential effects on some of the measured metabolic outcomes. CONCLUSION: These results provide strong support for modest weight loss as a treatment for hypertension...
  59. ncbi Blood phospholipid fatty acid analysis of adults with and without attention deficit/hyperactivity disorder
    Genevieve S Young
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Lipids 39:117-23. 2004
    ..Although the exact cause of these variations is unknown, both environmental and genetic factors may be involved...
  60. ncbi Effect of diabetes mellitus and different treatments on plasma and erythrocyte phospholipid fatty acid composition in type 2 diabetics
    Yanik Rodríguez
    Department of Physiology and Biochemistry, Institute of Nutrition and Food Hygiene, Havana, Cuba
    Ann Nutr Metab 48:335-42. 2004
    ..The aim of the present study was to determine how the fatty acid composition of plasma and erythrocyte phospholipids is influenced by the diabetic condition and by dietary or glibenclamide treatment in type 2 diabetes...
  61. ncbi n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes
    E D Collett
    Molecular and Cell Biology Group, Faculty of Nutrition, and Center for Environmental and Rural Health, Texas A and M University, College Station, Texas 77843-2471, USA
    Am J Physiol Cell Physiol 280:C1066-75. 2001
    ..In view of the central role of oncogenic Ras in the development of colon cancer, the finding that n-3 and n-6 PUFA differentially modulate Ras activation may partly explain why dietary fish oil protects against colon cancer development...
  62. ncbi What are the health effects of fat?
    Ursel Wahrburg
    Fachhochschule Münster, Fachbereich Oecotrophologie, Corrensstrasse 25, 48149 Munster, Germany
    Eur J Nutr 43:I/6-11. 2004
    ....
  63. ncbi Fatty acid content of plasma lipids and erythrocyte phospholipids are altered following burn injury
    V C Pratt
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada T6G 2P5
    Lipids 36:675-82. 2001
    ....
  64. ncbi [Molecular mechanisms of action and health benefits of polyunsaturated fatty acids]
    Maricela Rodriguez-Cruz
    Uniddad de Investigación Médica en Nutrición, Centro Medico Nacional Siglo XXI, IMSS
    Rev Invest Clin 57:457-72. 2005
    ..Main food sources of PUFAs n-6 are corn, soy and safflower oil, and for PUFAs n-3 are fish, soy, canola oil and, flaxseed. Finally FAO/WHO recommends an optimal daily intake of n6/n3 of 5-10:1...
  65. ncbi Astrocytes in culture require docosahexaenoic acid to restore the n-3/n-6 polyunsaturated fatty acid balance in their membrane phospholipids
    Gaelle Champeil-Potokar
    Laboratoire de Nutrition et Securite Alimentaire, Institut National de la Recherche Agronomique, Jouy en Josas, France
    J Neurosci Res 75:96-106. 2004
    ..This reliable method of altering membrane phospholipid composition promises to be useful for studying the influence of n-6/n-3 imbalance on astrocyte function...
  66. ncbi Cholesterol and n-3 and n-6 fatty acid content in eggs from laying hens fed with red crab meal (Pleuroncodes planipes)
    S Carrillo-Domínguez
    Departamento de Nutricion Animal, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga Number 15, 14000 Mexico DF
    Poult Sci 84:167-72. 2005
    ..It was concluded that inclusion of red crab meal in laying hen rations at levels of 3 and 6% (P < 0.05) increased the n-3 and n-6 fatty acids content in eggs...
  67. ncbi Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length
    S L Elias
    Department of Paediatrics, University of British Columbia, Vancouver, Canada
    Am J Clin Nutr 73:807-14. 2001
    ..33) and between TFA and AA concentrations in cholesteryl esters (r = -0.23). CONCLUSION: The results suggest possible important effects of TFAs and of AA on fetal growth and length of gestation...
  68. ncbi Fat--the good, the bad and the trans
    George L Blackburn
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Forum Nutr 56:196-8. 2003
  69. ncbi Reversibility of n-3 fatty acid deficiency-induced alterations of learning behavior in the rat: level of n-6 fatty acids as another critical factor
    A Ikemoto
    Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori, Mizuhoku, Nagoya 467-8603, Japan
    J Lipid Res 42:1655-63. 2001
    ....
  70. ncbi Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y
    F Thies
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 73:539-48. 2001
    ..CONCLUSION: A moderate amount of EPA but not of other n-6 or n-3 polyunsaturated fatty acids can decrease NK cell activity in healthy subjects...
  71. ncbi The influence of chylomicron remnants on cholesteryl ester metabolism in cultured rat hepatocytes: comparison of the effects of particles enriched in n-3 or n-6 polyunsaturated fatty acids
    K M Botham
    Department of Physiology, University of the Basque Country, Medical School, Bilbao, Spain
    Biochim Biophys Acta 1534:96-109. 2001
    ....
  72. ncbi Rationale and study design of dietary intervention in patients polypectomized for tumors of the colorectum
    Shinkan Tokudome
    Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, Japan
    Jpn J Clin Oncol 32:550-3. 2002
    ..A randomized controlled trial is under way to secure enough patients, sustain compliance/adherence and minimize dropouts...
  73. ncbi Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women
    Sheila M Innis
    Department of Pediatrics, University of British Columbia, Vancouver, Canada
    Am J Clin Nutr 77:473-8. 2003
    ..Little is known about n-3 fatty acid intakes in pregnant women, although human milk concentrations of DHA have decreased in recent years...
  74. ncbi Modulation of essential (n-6):(n-3) fatty acid ratios alters fatty acid status but not bone mass in piglets
    Hope A Weiler
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba R3T 2N2 Canada
    J Nutr 132:2667-72. 2002
    ..The results may be of relevance to the nutritional management of preterm infants whose DHA status is often too low and bone resorption too high...
  75. ncbi Inhibition of intracellular peroxides and apoptosis of lymphocytes in lupus-prone B/W mice by dietary n-6 and n-3 lipids with calorie restriction
    C P Reddy Avula
    University of Texas Health Science Center, Department of Medicine, San Antonio 78229 3900, USA
    J Clin Immunol 22:206-19. 2002
    ..In summary, CR resulted in decreased apoptosis accompanied by alterations in Fas, Fas-L, and Bcl-2 expression in old mice, increased life span, and delayed onset of kidney disease...
  76. ncbi Dietary n-3 and n-6 fatty acids alter avian metabolism: molecular-species composition of breast-muscle phospholipids
    Ronald E Newman
    Faculty of Veterinary Science, University of Sydney, Camden, NSW 2570, Australia
    Br J Nutr 88:19-28. 2002
    ....
  77. ncbi Dietary n-3 and n-6 fatty acids alter avian metabolism: metabolism and abdominal fat deposition
    Ronald E Newman
    Faculty of Veterinary Science, University of Sydney, Camden, NSW, Australia
    Br J Nutr 88:11-8. 2002
    ..In addition, the PUFA-rich diets lowered plasma concentrations of serum triacylglycerols and cholesterol. The findings indicate that dietary fatty acid profile influences nutrient partitioning in broiler chickens...
  78. ncbi Cardiac membrane fatty acid composition modulates myocardial oxygen consumption and postischemic recovery of contractile function
    Salvatore Pepe
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Medical Research Institute, Monash University Faculty of Medicine, Melbourne, Australia
    Circulation 105:2303-8. 2002
    ..Fish oils modify cardiac membrane phospholipid fatty acid composition with potent antiarrhythmic effects. We tested the effects of dietary fish oil on ventricular hemodynamics and myocardial oxygen consumption (MVO2)...
  79. ncbi On the reanalysis of the GISSI-Prevenzione
    Alexander Leaf
    Circulation 105:1874-5. 2002
  80. ncbi Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions
    Jishen Pan
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, New York 10595, USA
    Chem Res Toxicol 15:367-72. 2002
    ..These results may be important for the understanding of the specific roles of different types of fatty acids in tumorigenesis...
  81. ncbi Importance of seafood as nutrient source in the diet of Belgian adolescents
    I Sioen
    Department of Public Health, and Department of Food Safety and Food Quality, Ghent University, Ghent, Belgium
    J Hum Nutr Diet 20:580-9. 2007
    ..The aim of this study was to investigate the importance of seafood as a nutrient source in adolescents' diet and the extent to which seafood consumption can increase the intake of omega-3 polyunsaturated fatty acids and vitamin D...
  82. ncbi Short-term efficacy of enteral nutrition in the treatment of active Crohn's disease: a randomized, controlled trial comparing nutrient formulas
    Toshihiro Sakurai
    Department of Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino, Japan
    JPEN J Parenter Enteral Nutr 26:98-103. 2002
    ..We therefore performed a prospective, randomized, controlled study to compare the effects of nutrient formulas differing in the amount of medium-chain triglycerides (MCT)...
  83. ncbi Desirable intakes of polyunsaturated fatty acids in Indonesian adults
    Asikin Hanafiah
    Expect Panel on Nutrition, Indonesian Heart Foundation
    Asia Pac J Clin Nutr 16:632-40. 2007
    ..In the meantime, the Advisory Group has recommended that the AHA (American Heart Association) and ISSFAL (International Society for the Study of Fatty Acids and Lipids) recommendations obtain until the end of 2007...
  84. ncbi Influence of dietary fats on c-Fos-like immunoreactivity in mouse hypothalamus
    H Wang
    Metabolic Research Center, Department of Biomedical Science, University of Wollongong, Wollongong, Australia
    Brain Res 843:184-92. 1999
    ..In contrast, diets equally high in PUFA (particularly of the n-3 class) neither increase adiposity nor derange the lateral/medial neuronal activity balance...
  85. ncbi Essential and long-chain polyunsaturated fatty acid status and fatty acid composition of breast milk of lactating adolescents
    Flavia Meneses
    Laboratorio de Bioquimica Nutricional e de Alimentos, Departamento de Bioquimica, Instituto de Quimica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, CT Bl A, 21949 909, Rio de Janeiro, Brazil
    Br J Nutr 100:1029-37. 2008
    ..In general, PUFA in milk from adolescents presented few associations with their concentrations in plasma NEFA and with maternal status. However, milk DHA was associated with maternal LCPUFA and DHA states...
  86. ncbi Dietary alpha-linolenic acid lowers postprandial lipid levels with increase of eicosapentaenoic and docosahexaenoic acid contents in rat hepatic membrane
    H K Kim
    Department of Food and Nutrition, Seoul National University, Korea
    Lipids 36:1331-6. 2001
    ..These results suggest that n-3 ALA has more of a hypolipidemic effect than n-6 LA and that the hypolipidemic effect of n-3 PUFA may be partly related to the increase of EPA and DHA in hepatic membrane...
  87. ncbi Effects of dietary fatty acids and exercise on body-weight regulation and metabolism in rats
    Michael Pellizzon
    Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, USA
    Obes Res 10:947-55. 2002
    ..To assess the interaction of high-fat diets (HF) made with different dietary fatty acids and exercise on body-weight regulation, adiposity, and metabolism...
  88. ncbi Adipose tissue biomarkers of fatty acid intake
    Ana Baylin
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 76:750-7. 2002
    ..Biomarkers can provide a more accurate measure of long-term intake than can dietary questionnaires...
  89. ncbi [Possibilities for correction of n-3 fatty acids insufficiency in the Hungarian population]
    József Perédi
    Elelmiszertudományi Kar, Gabona és Iparinövény Technológiai Tanszék, Szent Istvan Egyetem, Budapest
    Orv Hetil 143:2587-91. 2002
    ..The author has presented presumable reasons of this deficiency, and has highlighted that production, marketing and consumption of special 'functional foods', rich in n-3 fatty acids may considerably improve this unfavourable situation...
  90. ncbi The (n-3) fatty acid dose, independent of the (n-6) to (n-3) fatty acid ratio, affects the plasma fatty acid profile of normal dogs
    Jean A Hall
    Human Nutrition Research Laboratory, Department of Nutrition, School of Human Environmental Sciences, University of North Carolina, Greensboro, NC 27402 6170, USA
    J Nutr 136:2338-44. 2006
    ..Results from our studies indicate that approximately 175 mg DHA/(kg body weight . d) is required to attain maximum plasma levels of DHA...
  91. ncbi Diet and risk of dementia: Does fat matter?: The Rotterdam Study
    M J Engelhart
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 59:1915-21. 2002
    ....
  92. ncbi Effect of dietary supplementation of fatty acids and vitamins on the breeding performance of the carp Catla catla
    S Nandi
    Central Institute of Freshwater Aquaculture, Kausalyaganga, India
    Reprod Nutr Dev 41:365-75. 2001
    ..The various data thus obtained suggest that dietary supplementation of both n-3 and n-6 PUFA, is essential to improve gonadal maturation, breeding performance and spawn recovery in the Catla female broodstock...
  93. ncbi Fatty acids in liver, muscle and gonad of three tropical rays including non-methylene-interrupted dienoic fatty acids
    Mohamed Vall Ould El Kebir
    Laboratoire de Phytochimie de Marseille, UMR CNRS 6171, Faculte des Sciences et Techniques de Saint Jerome, Universite Paul Cezanne, Case 531, Avenue Escadrille Normandie Niemen, 13397 Marseille Cedex 20, France
    Lipids 42:525-35. 2007
    ..These acids are quite unusual in fish and unprecedented in rays. The 22:2 Delta6,14 acid occurred in gonads of male specimens of R. cemiculus at 2.9%...
  94. ncbi Fatty acid composition and antioxidant levels in muscle tissue of different Mediterranean marine species of fish and shellfish
    Siro Passi
    Istituto Dermopatico dell Immacolata IDI, IRCCS, Via Monti di Creta, 104, Roma, Italy
    J Agric Food Chem 50:7314-22. 2002
    ....
  95. ncbi Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults
    F Thies
    Department of Biochemistry, University of Oxford, United Kingdom
    Lipids 36:1183-93. 2001
    ....
  96. ncbi Replacement of dietary fish oils by alpha-linolenic acid-rich oils lowers omega 3 content in tilapia flesh
    Ioannis T Karapanagiotidis
    Institute of Aquaculture, University of Stirling, Stirling, FK9 4LA, Scotland
    Lipids 42:547-59. 2007
    ....
  97. ncbi Acyl composition of muscle membranes varies with body size in birds
    A J Hulbert
    Metabolic Research Centre, University of Wollongong, Wollongong, NSW 2522, Australia
    J Exp Biol 205:3561-9. 2002
    ..This allometric variation in phospholipid acyl composition is discussed with respect to both the metabolic intensity and lifespan of different sized bird species...
  98. ncbi Influence of omega-3 fatty acids on the growth of human colon carcinoma in nude mice
    Taeko Kato
    Department of Biochemistry, College of Agriculture, Biotechnology and Natural Resources, University of Nevada, Reno, NV 89557, USA
    Cancer Lett 187:169-77. 2002
    ....
  99. ncbi Respiratory and allergic diseases: from upper respiratory tract infections to asthma
    Raja Jaber
    Division of Wellness and Chronic Illness, Department of Family Medicine, University Hospital and Medical Center, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8461, USA
    Prim Care 29:231-61. 2002
    ..Patients welcome physician guidance when exploring the breadth of treatments available today. A true patient-physician partnership is always empowering to patients who are serious about regaining their function and health...
  100. ncbi Modulation of experimental colon tumorigenesis by types and amounts of dietary fatty acids
    C V Rao
    Division of Nutritional Carcinogenesis, American Health Foundation, Valhalla, New York 10595, USA
    Cancer Res 61:1927-33. 2001
    ....
  101. pmc The effect of omega-6 and omega-3 fatty acids on 3H-thymidine incorporation in hepatoma 7288CTC perfused in situ
    L A Sauer
    Cancer Research Laboratory, Mary Imogene Bassett Hospital, Cooperstown, New York 13326
    Br J Cancer 66:297-303. 1992
    ..Plasma free omega-3 fatty acids appear to modulate the effect of linoleic acid by competitively inhibiting its uptake. These relationships could explain the actions of dietary linoleic and omega-3 fatty acids on tumour growth in vivo...

Research Grants62

  1. Omega-3 fat to reduce risk for breast cancer
    WANDA ELAINE HARDMAN; Fiscal Year: 2010
    ..3 fatty acids (FAs) is usually associated with a lower incidence of breast cancer whereas exposure to high omega 6 fatty acids during gestation and lactation has been shown to increase the future incidence of mammary cancer in mice...
  2. Therapeutic Value of Fish Oil Rx on SLE and Bone Loss in Mice
    GABRIEL J J FERNANDES; Fiscal Year: 2012
    ..The proposed studies will also help to gain insight to undertake clinical studies to prevent renal and CVD as well as bone loss in SLE patients. ..
  3. Regulation of Hepatic Metabolic Function by Parenteral Nutrition
    Douglas G Burrin; Fiscal Year: 2013
    ..These studies in premature pigs are highly translational and will lead to new clinical practices in nutritional support and prevention of liver disease in infants. ..
  4. Lipid Activated Nuclear Receptors in Age-Related Macular Degeneration
    Goldis Malek; Fiscal Year: 2013
    ..Understanding the mechanisms underlying deposit formation and identifying signaling pathways key to disease initiation and progression will open up new avenues for therapeutic strategies in early 'dry'AMD. ..
  5. ENALS IN TUMORIGENESIS
    Fung Lung Chung; Fiscal Year: 2010
    ..These studies will provide insight into the significance of cyclic dG modifications as a class of endogenous DNA lesions in apoptosis and shed light on the mechanisms by which omega-3 fatty acids protect against colon carcinogenesis. ..
  6. The Role of GPR120 and Omega-3 Fatty Acids in Steatosis and Systemic Inflammation
    Sarah Carlson; Fiscal Year: 2013
    ..Markers of insulin resistance, peripheral fat inflammation and liver injury will be compared between groups. ..
  7. DHA Mechanisms in Obesity-mediated Cardiac Remodeling Post-Myocardial Infarction
    Ganesh Halade; Fiscal Year: 2012
    ..The results of these studies will clarify the role of DHA in post-MI remodeling in the setting of aging and obesity. ..
  8. DHA Mechanisms in Obesity-mediated Cardiac Remodeling Post-Myocardial Infarction
    Ganesh Halade; Fiscal Year: 2013
    ..The results of these studies will clarify the role of DHA in post-MI remodeling in the setting of aging and obesity. ..
  9. Role of 12-lipoxygenase in platelet reactivity and type 2 diabetes mellitus
    MICHAEL ALLAN HOLINSTAT; Fiscal Year: 2013
    ..Finally, this study will give significant insight into alternative approaches such as 12-LOX inhibition in order to regulate platelet activity in the growing T2DM population. ..
  10. Clinical &metabolic effects of altering n-3 &n-6 fatty acids in migraine (RCT)
    John Douglas Mann; Fiscal Year: 2013
    ..abstract_text> ..
  11. Saturated Fatty Acid and Cardiovascular Disease
    Eric J Smart; Fiscal Year: 2010
    ..Aim 3: To determine if an endothelial-specific caveolin null mouse is protected from saturated fatty acid-induced peroxynitrite production andsubsequently atherosclerosis. ..
  12. Pilot Study on Mammary Expression of Novel Desaturases
    ALISON VAN EENENNAAM; Fiscal Year: 2005
    ....
  13. EFFECTS OF POLYUNSATURATED FATTY ACIDS ON MEGAKARYOCYTES
    PAUL SCHICK; Fiscal Year: 1991
    ..of omega 3 fatty acids, eicosapentaenoic and docosahexaenoic, and alpha linolenic acid, as well as the omega 6 fatty acids, linoleic and gamma linolenic acids on megakaryocytes...
  14. NMU INDUCED MAMMARY CANCER AND OMEGA 3 FATTY ACIDS
    Leonard Cohen; Fiscal Year: 1990
    ..The ultimate objective of this proposal is the development of an optimal omega-6/omega-3 dietary fatty acid balance for the primary and secondary prevention of breast cancer in high-risk countries, such as the U.S.A...
  15. A prospective study of diet and endometriosis
    Stacey Missmer; Fiscal Year: 2006
    ..These analyses will be the first to evaluate the relation between these dietary factors and this important and understudied cause of morbidity among premenopausal women. [unreadable] [unreadable]..
  16. Nostalgia in the WNT signaling pathway; fatty acids, epigenetics and leukemia
    Vincent Sollars; Fiscal Year: 2009
    ..stem cell differentiation will be used for more manipulative studies of the effect of omega 3/ omega 6 fatty acids on differentiation and DNA methylation...
  17. Fatty Acids Alter Endothelial Nitric Oxide Production
    C Hart; Fiscal Year: 2004
    ..These novel studies will clarify cellular and molecular mechanisms of endothelial dysfunction that contribute to diabetic macrovascular disease. ..
  18. The Relationship of n-3 Fatty Acids with Pain and Synovium in knee OA
    Kristin Baker; Fiscal Year: 2009
    ..It is a major public health issue with substantial economic impact that will increase as the population ages. Individuals with the disease are eager for nonpharmacological treatments such as a nutrition intervention. ..
  19. EFFECTS OF DIETARY FAT ON LIPID PEROXIDATIVE INJURY
    Jeffrey Beckman; Fiscal Year: 1992
    ....
  20. NUTRITIONAL CONTROL OF INTERMEDIARY METABOLISM
    PETER STACPOOLE; Fiscal Year: 1991
    ..We anticipate that direct or GIP-mediated suppression of insulin release may be an additional mechanism by which a fish oil diet impairs glucose metabolism in diabetic...
  21. DIETARY FAT: PHYSIOLOGICAL FUNCTION
    Howard Sprecher; Fiscal Year: 1990
    ..The overall goal of these studies is to determine how dietary fat change regulates the unsaturated fatty acid composition of individual phospholipids in prostaglandin producing tissues...
  22. IN VITRO INDUCTION & MODULATION OF MAMMARY PRENEOPLASIA
    Nitin Telang; Fiscal Year: 1991
    ..The proposal will provide a basis for future studies with focus in more detail on the mechanisms in human mammary carcinogenesis and its prevention...
  23. Maternal fatty acids, birth weight and child development
    Emily Oken; Fiscal Year: 2007
    ..abstract_text> ..
  24. MODULATION OF SKELETAL INTERGRITY--DIETARY FAT WITH AGE
    REBECCA CORWIN; Fiscal Year: 1999
    ..abstract_text> ..
  25. OMEGA-3 FATTY ACIDS: INHIBITORS OF COLON CANCER
    ELEANOR DESCHNER; Fiscal Year: 1990
    ....
  26. Mechanisms of Cox2 Induced Tumorigenesis
    Timothy Hla; Fiscal Year: 2006
    ..Finally, we will employ a mass-spectrometry based state-of-the-art proteomic technology to identify novel polypeptides regulated by Cox-2 overexpression in the mammary gland, with a focus on mediators of apoptosis and angiogenesis. ..
  27. RETINOIDS, M6P/IGF II RECEPTOR & CELL GROWTH REGULATION
    Jing Kang; Fiscal Year: 2002
    ..This knowledge may lead to novel or more effective therapeutic and preventive approaches for cancer and developmental defects. ..
  28. Omega-6/Omega-3 Fatty Acid Ratio and Tumorigenesis
    Jing Kang; Fiscal Year: 2009
    ..Information derived from these studies will increase our understanding of the importance of n-3 fatty acids as well as n-6/n-3 fatty acid ratio in cancer prevention and help guide dietary advice. ..
  29. OMEGA 3 LIPIDS AND CALORIES EFFECT ON SLE AND AGING
    Gabriel Fernandes; Fiscal Year: 2003
    ....
  30. Prolongation of lifespan by n-3 fatty acids and calorie restriction
    GABRIEL J FERNANDES; Fiscal Year: 2010
    ..n-3 (fish oil) fatty acids containing diets fed to mice ad-libitum and 40% or 20% calorie restriction to measure optimal lifespan, anti-inflammatory cytokines and bone mass, in long-lived C57BL/6 and fat-1 tg mice. ..
  31. Effect of Calorie Restriction on Infection During Aging
    Gabriel Fernandes; Fiscal Year: 2004
    ..This new information may become very useful to prevent any sudden onset of infection during CR studies and/or studies of weight reduction either by diet or by drugs in humans. ..
  32. EFFECTS OF n-3 FATTY ACIDS AND EXERCISE ON OSTEOPOROSIS
    Gabriel Fernandes; Fiscal Year: 2008
    ..In summary, the proposed studies will investigate the dietary and molecular mechanisms of bone loss during aging in OVX mice and its attenuation by low-cost n-3 lipid supplements with moderate exercise as alternatives to HRT. ..
  33. Benefits of conjugated linoleic acid on aging
    Gabriel Fernandes; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  34. Gas phase derivatization for lipidomic MS analysis
    JAMES BRENNA; Fiscal Year: 2007
    ....
  35. Lipidomics Session ISSFAL 2006
    JAMES BRENNA; Fiscal Year: 2006
    ..ISSFAL 2006 is expected to be among the most important international lipid metabolism conferences of the year, and a lipidomics symposium is timely given the increasing progress in this area. [unreadable] [unreadable] [unreadable]..
  36. Prostate Cancer: A Mouse Model Testing 15-Lipoxygenase-1
    Uddhav Kelavkar; Fiscal Year: 2004
    ..abstract_text> ..
  37. PRECISE ISOTOPE RATIO CHROMATOGRAPHY AND STABLE TRACERS
    JAMES BRENNA; Fiscal Year: 2004
    ..The successful accomplishment of these plans will yield new tools and experimental approaches for investigation of the impact of developmental factors and recent physiological history on development of chronic disease. ..
  38. LCPUFA Status and Birth Outcome in India
    JAMES BRENNA; Fiscal Year: 2007
    ..Positive results would justify an intervention studies to include LCPUFA in the diets of pregnant women in developed and developing countries. ..
  39. DIETARY ESSENTIAL FATTY ACID ACCUMULATION IN RETINA
    JAMES BRENNA; Fiscal Year: 2002
    ..Sub-normal development will be directly revealed via functional tests to assess the impact of low omega-3 fatty acid status on develop of vision acid status on development of vision and related health parameters. ..
  40. Role of Stearoyl-CoA Desaturase in Metabolism
    James M Ntambi; Fiscal Year: 2010
    ..We have discovered a mechanism that partitions fat away from storage towards its burning in the fed state. Our research will contribute to the treatment of human obesity, diabetes and other metabolic diseases. ..
  41. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose M Ordovas; Fiscal Year: 2010
    ..This evidence-based knowledge will contribute to a rational approach toward more effective dietary recommendations aimed to decrease health disparities and to a better CVD prevention. ..
  42. Cysteine, Related Gene Variants and Breast Cancer Risk
    Walter C Willett; Fiscal Year: 2010
    ....
  43. WEIGHT LOSS IN OBESE BREAST CANCER SURVIVORS
    Zora Djuric; Fiscal Year: 2002
    ..This study should be useful to determine certain psychosocial are associated with extent of weight loss, and in turn whether weight loss is associated with changes in selected markers of breast cancer risk. ..
  44. NEURAL AND ENDOCRINE REGULATION OF BRAIN AND BEHAVIOR
    Richard Wurtman; Fiscal Year: 2003
    ..abstract_text> ..
  45. EFFECTS OF BUSPIRONE IN WITHDRAWAL FROM OPIATES
    Laure Buydens Branchey; Fiscal Year: 2002
    ..Buspirone has additional advantages. It is not sedating, has no withdrawal symptoms, has no abuse potential, does not potentiate central nervous system depressants and does not induce psychomotor impairment. ..
  46. Genetic Polymorphisms Benign Prostatic Hyperplasia
    ROSEBUD ROBERTS; Fiscal Year: 2004
    ..This community-based cohort study should provide insights that should improve our understanding of the genetic control of hormonal mechanisms in the pathogenesis of BPH. ..
  47. MODULATION OF INTESTINAL OBESITY SIGNALS
    Patrick Tso; Fiscal Year: 2004
    ..In addition, the apo A-IV knockout and transgenic animals will be used to determine if there is interaction between the lymph glucose and lymph apo A-IV signals. ..
  48. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2009
    ..4. To conduct a case-case association study to determine if morphological markers of apoptosis in tumor and surrounding free tissue differ among cases with varying exposure levels of a given putative environmental/genetic risk factor. ..
  49. Niacin, n-3 fatty acids and insulin resistance
    William Harris; Fiscal Year: 2007
    ..This should lead to more effective therapy for the dyslipidemia of insulin resistance and ultimately to reduced risk for CHD in this burgeoning patient population. ..
  50. Integration of Stress and Reproductive Axes by Dopamine
    Simon Evans; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  51. Gene-diet interactions and dietary cholesterol response
    Jan Breslow; Fiscal Year: 2005
    ..of additional novel dietary cholesterol regulated genes and other genes determining differences in cholesterol metabolism and diet response between the sexes will be performed utilizing oligonucleotide microarrays, ..
  52. Fatty Acids and Cardiovascular Health
    Dariush Mozaffarian; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  53. Plasma Markers of Dietry Intervention to Delay Cognitiv*
    JAE KANG; Fiscal Year: 2005
    ..Importantly, results from the proposed grant will lay the groundwork for a future, large-scale comprehensive study to examine dietary interventions to delay cognitive function. ..
  54. Ambient Air Pollution, Preeclampsia, and Preterm Delivery
    Michelle Williams; Fiscal Year: 2008
    ..The results could also contribute to the body of heath-related science that influences air quality standards and policies. [unreadable] [unreadable] [unreadable]..
  55. Vascular and Inflammatory Predictors of MCI Risk and Progression
    ROSEBUD ROBERTS; Fiscal Year: 2008
    ..The K01 award will culminate in an R01 application that will pave the way for the candidate to become an independent investigator in MCI and AD research. [unreadable] [unreadable] [unreadable]..
  56. Alcohol-Metabolizing Gene Variation, Lipids, Hemostatic Factors and CVD
    Kelly Volcik; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  57. Congenital Muscular Dystrophy Workshop
    Steven Moore; Fiscal Year: 2008
    ..Life expectancy ranges from a few months to a few years. [unreadable] [unreadable] [unreadable] [unreadable]..
  58. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Jill Norris; Fiscal Year: 2009
    ....
  59. Brain Uptake and Utilization of Fatty Acids and Lipids
    Paul Watkins; Fiscal Year: 2004
    ..Mol. Neurosci., which has committed to publish the proceedings of the proposed meeting. ..
  60. Animal Models of Diabetic Vascular Disease
    Jan Breslow; Fiscal Year: 2005
    ..We will then use new genetic technology to combine the various required alleles to make a diabetogenic- macrovascular disease model that is easy to breed and transfer to other investigators. ..
  61. Interaction of Nutrient & Organochlorine Absorption
    Patrick Tso; Fiscal Year: 2010
    ..The proposed research is important because of the biological and clinical importance of OCs in health and disease and they provide considerable new insights into how OCs are carried and delivered to the various organs in the body. ..