gamma linolenic acid

Summary

Summary: An omega-6 fatty acid produced in the body as the delta 6-desaturase metabolite of linoleic acid. It is converted to dihomo-gamma-linolenic acid, a biosynthetic precursor of monoenoic prostaglandins such as PGE1. (From Merck Index, 11th ed)

Top Publications

  1. ncbi Evening primrose oil effects on osteoclasts during tooth movement
    Suwimol Taweechaisupapong
    Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen 40002, Thailand
    Angle Orthod 75:356-61. 2005
  2. ncbi The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life
    M Ranieri
    Physical Medicine and Rehabilitation Unit, Neurological and Psychiatric Sciences Department, Aldo Moro University, Bari 70124, Italy
    Int J Immunopathol Pharmacol 22:45-50. 2009
  3. ncbi Dietary gamma-linolenate attenuates tumor growth in a rodent model of prostatic adenocarcinoma via suppression of elevated generation of PGE(2) and 5S-HETE
    Hung Pham
    Department of Dermatology TB 192, School of Medicine, University of California Davis, Davis, CA 95616, USA
    Prostaglandins Leukot Essent Fatty Acids 74:271-82. 2006
  4. pmc LC/ESR/MS study of spin trapped carbon-centred radicals formed from in vitro lipoxygenase-catalysed peroxidation of gamma-linolenic acid
    Qingfeng Yu
    Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University, Fargo, ND 58105, USA
    Free Radic Res 42:442-55. 2008
  5. ncbi Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in glioma
    H A Leaver
    Department of Clinical Neurosciences, Edinburgh University, UK
    Prostaglandins Leukot Essent Fatty Acids 66:19-29. 2002
  6. ncbi Distribution and metabolism of dihomo-gamma-linolenic acid (DGLA, 20:3n-6) by oral supplementation in rats
    Rumi Umeda-Sawada
    Department of Nutrition and Food Science, Ochanomizu University, Tokyo, Japan
    Biosci Biotechnol Biochem 70:2121-30. 2006
  7. ncbi Induction of apoptosis in K562/ADM cells by gamma-linolenic acid involves lipid peroxidation and activation of caspase-3
    Xiuqin Kong
    Department of Biology, College of Life Science, Nanjing University, Nanjing, Jiangsu, China
    Chem Biol Interact 162:140-8. 2006
  8. ncbi Dynamics of reactive oxygen intermediate production in human glioma: n-6 essential fatty acid effects
    H A Leaver
    Department of Pharmacology, University of Edinburgh, UK
    Eur J Clin Invest 29:220-31. 1999
  9. ncbi Gamma-linolenic acid alters the composition of mitochondrial membrane subfractions, decreases outer mitochondrial membrane binding of hexokinase and alters carnitine palmitoyltransferase I properties in the Walker 256 rat tumour
    Alison Colquhoun
    Departamento de Histologia e Embriologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, CEP 05508 900, Brazil
    Biochim Biophys Acta 1583:74-84. 2002
  10. ncbi gamma-Linolenic acid and eicosapentaenoic acid induce modifications in mitochondrial metabolism, reactive oxygen species generation, lipid peroxidation and apoptosis in Walker 256 rat carcinosarcoma cells
    A Colquhoun
    Departamento de Histologia e Embriologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Brazil
    Biochim Biophys Acta 1533:207-19. 2001

Research Grants

Detail Information

Publications216 found, 100 shown here

  1. ncbi Evening primrose oil effects on osteoclasts during tooth movement
    Suwimol Taweechaisupapong
    Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen 40002, Thailand
    Angle Orthod 75:356-61. 2005
    ..05). This study indicates that oral administration of EPO can increase the number of osteoclasts and may accelerate orthodontic tooth movement...
  2. ncbi The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life
    M Ranieri
    Physical Medicine and Rehabilitation Unit, Neurological and Psychiatric Sciences Department, Aldo Moro University, Bari 70124, Italy
    Int J Immunopathol Pharmacol 22:45-50. 2009
    ..Oral treatment with alpha-lipoic acid (ALA) and gamma-linolenic acid (GLA) for six weeks in synergy with rehabilitation therapy improved neuropathic symptoms and deficits in patients with radicular neuropathy...
  3. ncbi Dietary gamma-linolenate attenuates tumor growth in a rodent model of prostatic adenocarcinoma via suppression of elevated generation of PGE(2) and 5S-HETE
    Hung Pham
    Department of Dermatology TB 192, School of Medicine, University of California Davis, Davis, CA 95616, USA
    Prostaglandins Leukot Essent Fatty Acids 74:271-82. 2006
    ..Taken together, the findings showed that intake of GLA-enriched diet does reduce prostatic cancer development in L-W rats and could serve as a non-toxic adjunct in management of human prostatic cancer...
  4. pmc LC/ESR/MS study of spin trapped carbon-centred radicals formed from in vitro lipoxygenase-catalysed peroxidation of gamma-linolenic acid
    Qingfeng Yu
    Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University, Fargo, ND 58105, USA
    Free Radic Res 42:442-55. 2008
    ..The results provided a good starting point for ongoing research in defining the possible biological effects of radicals generated from GLA peroxidation...
  5. ncbi Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in glioma
    H A Leaver
    Department of Clinical Neurosciences, Edinburgh University, UK
    Prostaglandins Leukot Essent Fatty Acids 66:19-29. 2002
    ..The antitumour activity of three HUFA (arachidonic acid, gamma linolenic acid and eicosapentaenoic acid) were studied in glioma cells and tissue...
  6. ncbi Distribution and metabolism of dihomo-gamma-linolenic acid (DGLA, 20:3n-6) by oral supplementation in rats
    Rumi Umeda-Sawada
    Department of Nutrition and Food Science, Ochanomizu University, Tokyo, Japan
    Biosci Biotechnol Biochem 70:2121-30. 2006
    ..The mechanism for GLA administration to improve atopic eczema is thought to involve an increase in the concentration of DGLA metabolized from GLA, so these results suggest that the dietary effect of DGLA would be more dominant than GLA...
  7. ncbi Induction of apoptosis in K562/ADM cells by gamma-linolenic acid involves lipid peroxidation and activation of caspase-3
    Xiuqin Kong
    Department of Biology, College of Life Science, Nanjing University, Nanjing, Jiangsu, China
    Chem Biol Interact 162:140-8. 2006
    ..The results also showed that the malondialdehyde (MDA) content was also significantly elevated, and antioxidant BHT could block GLA cytotoxity, indicating the cytotoxity induced by GLA may be due to lipid peroxidation...
  8. ncbi Dynamics of reactive oxygen intermediate production in human glioma: n-6 essential fatty acid effects
    H A Leaver
    Department of Pharmacology, University of Edinburgh, UK
    Eur J Clin Invest 29:220-31. 1999
    ..Local essential fatty acid (EFA) deficiencies in tumour cells may limit tumour ROI generation. This deficiency may be rectified by the addition of exogenous EFA...
  9. ncbi Gamma-linolenic acid alters the composition of mitochondrial membrane subfractions, decreases outer mitochondrial membrane binding of hexokinase and alters carnitine palmitoyltransferase I properties in the Walker 256 rat tumour
    Alison Colquhoun
    Departamento de Histologia e Embriologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, CEP 05508 900, Brazil
    Biochim Biophys Acta 1583:74-84. 2002
    ....
  10. ncbi gamma-Linolenic acid and eicosapentaenoic acid induce modifications in mitochondrial metabolism, reactive oxygen species generation, lipid peroxidation and apoptosis in Walker 256 rat carcinosarcoma cells
    A Colquhoun
    Departamento de Histologia e Embriologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Brazil
    Biochim Biophys Acta 1533:207-19. 2001
    ....
  11. pmc Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes
    S Vartak
    Radiation Research Laboratory, Department of Radiology, University of Iowa, Iowa City 52242, USA
    Br J Cancer 77:1612-20. 1998
    ..The lipoxygenase inhibitor NDGA did not affect the toxicity produced by GLA. Thus, GLA is toxic to the neoplastic astrocytoma cells but not to normal astrocytes...
  12. ncbi Modifications in mitochondrial metabolism and ultrastructure and their relationship to tumour growth inhibition by gamma-linolenic acid
    A Colquhoun
    Departamento de Histologia e Embriologia, , , , Brasil
    Mol Cell Biochem 218:13-20. 2001
    ....
  13. ncbi From bench to the clinic: gamma-linolenic acid therapy of human gliomas
    Undurti N Das
    UND Life Sciences, 1083 Main Street, Walpole, MA 02081, USA corrected
    Prostaglandins Leukot Essent Fatty Acids 70:539-52. 2004
    ..In view of this, large-scale, double blind studies are needed to establish the usefulness of GLA in the treatment of malignant brain tumors...
  14. ncbi Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies
    Undurti N Das
    UND Life Sciences, Shaker Heights, OH 42100, USA
    Med Sci Monit 13:RA119-31. 2007
    ..The low neurotoxicity of GLA to normal brain neurons and selective activity against tumor cells suggests that it could be an effective anti-glioma molecule...
  15. ncbi Intracellular oxidation by human glioma cell populations: effect of arachidonic acid
    H A Leaver
    Department of Clinical Neurosciences, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU UK
    Prostaglandins Leukot Essent Fatty Acids 70:449-53. 2004
    Arachidonic acid (AA) and Gamma linolenic acid have been shown to limit glioma cell growth, stimulate apoptosis and lipid peroxidation...
  16. pmc Effect of polyunsaturated fatty acids on the drug sensitivity of human tumour cell lines resistant to either cisplatin or doxorubicin
    J A Plumb
    CRC Department of Medical Oncology, University of Glasgow, Bearsden, UK
    Br J Cancer 67:728-33. 1993
    ..The combination of polyunsaturated fatty acids and cytotoxic drugs may have clinical potential provided that the normal tissue toxicities of the two treatments are not additive...
  17. pmc Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression
    Juliano Andreoli Miyake
    Department of Cell and Developmental Biology, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, SP, Brazil
    Lipids Health Dis 8:8. 2009
    ..The aim of the present study was to determine the mechanisms by which gamma-linolenic acid (GLA) osmotic pump infusion alters glioma cell proliferation, and whether it affects cell cycle control and angiogenesis in the C6 glioma in vivo...
  18. ncbi Highly unsaturated fatty acid induced tumour regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumour biomass, apoptosis and neuronal tissue histology
    H A Leaver
    Department of Clinical Neurosciences, University of Edinburgh, UK
    Prostaglandins Leukot Essent Fatty Acids 67:283-92. 2002
    ..model, using the C6 glioma cell line, was used to investigate the bioactivity of locally infused n-6 HUFA gamma linolenic acid (GLA). Rat brains (15 normal and 37 C6 tumour bearing) were infused with vehicle or GLA 200 microM-2 mM...
  19. ncbi Intravesical meglumine gamma-linolenic acid in superficial bladder cancer: an efficacy study
    N M Harris
    Solent Department of Urology, St Mary s Hospital NHS Trust, Portsmouth, UK
    Eur Urol 42:39-42. 2002
    ..We assessed the efficacy of the novel intravesical formulation, meglumine gamma-linolenic acid (MeGLA), in a phase II trial, in patients with recurrent, superficial bladder cancer...
  20. ncbi Peroxisome proliferator activated receptor-gamma (PPAR-gamma) mediates the action of gamma linolenic acid in breast cancer cells
    W G Jiang
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, UK
    Prostaglandins Leukot Essent Fatty Acids 62:119-27. 2000
    b>Gamma linolenic acid (GLA) is a polyunsaturated fatty acid, which induces cytotoxicity and regulates cell adhesion in cancer cells. The molecular mechanism of these actions is not clear...
  21. ncbi Effect of dietary GLA+/-tamoxifen on the growth, ER expression and fatty acid profile of ER positive human breast cancer xenografts
    F S Kenny
    Professorial Unit of Surgery, City Hospital, Nottingham, United Kingdom
    Int J Cancer 92:342-7. 2001
    b>Gamma linolenic acid (GLA) possesses a number of selective anti-tumour properties including modulation of steroid receptor structure and function...
  22. ncbi Effects of gamma-linolenic acid and docosahexaenoic acid in formulae on brain fatty acid composition in artificially reared rats
    G R Ward
    Department of Health Studies and Gerontology, University of Waterloo, Ontario, Canada
    Lipids 34:1057-63. 1999
    ..These results suggest that dietary GLA, during development, differs from high dietary levels of AA in that it does not lead to reductions in brain DHA...
  23. ncbi Five-lipoxygenase inhibitors reduce Panc-1 survival: the mode of cell death and synergism of MK886 with gamma linolenic acid
    K M Anderson
    Department of Medicine, Rush Medical College, Chicago, IL 60612, USA
    Anticancer Res 18:791-800. 1998
    ..In a European clinical trial, gamma linolenic acid, a polyunsaturated fatty acid that generates free radicals has been combined with 5-fluorouracil as ..
  24. ncbi Stereotactic radiosurgery XII. Large AVM and the failure of the radiation response modifier gamma linolenic acid to improve the therapeutic ratio
    E C Sims
    Department of Radiotherapy, St Bartholomew's Hospital, West Smithfield, London, UK
    Br J Neurosurg 15:28-34. 2001
    ....
  25. ncbi Gamma linolenic acid: an antiinflammatory omega-6 fatty acid
    Rakesh Kapoor
    Science and Technology, Bioriginal Food and Science Corp, 102 Melville Street, Saskatoon, SK S7J 0R1, Canada
    Curr Pharm Biotechnol 7:531-4. 2006
    ..b>Gamma linolenic acid (GLA, all cis 6, 9, 12-Octadecatrienoic acid, C18:3, n-6), is produced in the body from linoleic acid (all ..
  26. ncbi Gamma linolenic acid regulates expression of maspin and the motility of cancer cells
    W G Jiang
    University Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    Biochem Biophys Res Commun 237:639-44. 1997
    ..This study examined the effect of gamma linolenic acid (GLA), an essential fatty acid (EFA) with anticancer properties, on the expression of maspin and motility ..
  27. ncbi Structural characterization of triacylglycerol in several oils containing gamma-linolenic acid
    Satoru Shimizu
    The United Graduate School of Agriculture Sciences, Iwate University, Morioka, Iwate 020 8550, Japan
    Biosci Biotechnol Biochem 67:60-7. 2003
    ..8% in EPO, and 56.6% in BIO. In OBLO, the GLA level at the sn-2 position of the major TG species was higher than that in EPO. In BIO, the GLA level at the sn-2 position of the major TG species was lower than those in OBLO and EPO...
  28. ncbi The therapeutic effect of evening primrose oil in atopic dermatitis patients with dry scaly skin lesions is associated with the normalization of serum gamma-interferon levels
    Sungpil Yoon
    Department of Dermatology, College of Medicine, Inha University, Inchon, Republic of Korea
    Skin Pharmacol Appl Skin Physiol 15:20-5. 2002
    ..The restoration of serum IFN-gamma levels indicates that EPO might exert its effect through the modulation of the immunological mechanism involving IFN-gamma...
  29. ncbi Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults
    F Thies
    Department of Biochemistry, University of Oxford, United Kingdom
    Lipids 36:1183-93. 2001
    ....
  30. ncbi Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition
    Kathy E Wedig
    Division of Neonatology, Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Pediatr 152:140, 140.e1. 2008
  31. ncbi Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial
    Jacqueline Blommers
    Department of Clinical Epidemiology and Biostatistics, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    Am J Obstet Gynecol 187:1389-94. 2002
    ..The purpose of this study was to evaluate the effect of evening primrose oil and fish oil on breast pain in premenopausal women with severe chronic mastalgia, in a randomized double-blind factorial clinical trial...
  32. ncbi Anti-wrinkling effects of the mixture of vitamin C, vitamin E, pycnogenol and evening primrose oil, and molecular mechanisms on hairless mouse skin caused by chronic ultraviolet B irradiation
    Ho Song Cho
    LG Household and Healthcare Research Park, Daejeon, Korea
    Photodermatol Photoimmunol Photomed 23:155-62. 2007
    ....
  33. ncbi Low intensity laser therapy is comparable to bromocriptine-evening primrose oil for the treatment of cyclical mastalgia in Egyptian females
    G M Saied
    Department of General Surgery, Faculty of Medicine, Cairo University, Egypt
    Tanzan Health Res Bull 9:196-201. 2007
    ..05). This difference was more for the drug treated group than for the laser treated group, but in the latter, it acted on a wider sector of patients. In conclusion, LILT is recommended as a new treatment modality for cyclical mastalgia...
  34. ncbi Treating hot flushes without hormone replacement therapy
    Machelle M Seibel
    University of Massachusetts School of Medicine, Worcester, USA
    J Fam Pract 52:291-6. 2003
  35. ncbi Fatty acid composition of serum lipid classes in mice following allergic sensitisation with or without dietary docosahexaenoic acid-enriched fish oil substitution
    Ralph Ruhl
    Department of Biochemistry and Molecular Biology, Medical and Health Science Centre, University of Debrecen, Nagyerdei krt 98, H 4012 Debrecen, Hungary
    Br J Nutr 99:1239-46. 2008
    ....
  36. ncbi A direct method for regiospecific analysis of TAG using alpha-MAG
    F Turon
    SEA OIL, Beaumont Hague, France
    Lipids 37:817-21. 2002
    ..The present procedure, first demonstrated on a synthetic TAG, was then successfully applied to the analysis of borage oil, milkfat, and tuna oil...
  37. ncbi Structured lipids via lipase-catalyzed incorporation of eicosapentaenoic acid into borage (Borago officinalis L.) and evening primrose (Oenothera biennis L.) oils
    S P J Namal Senanayake
    Department of Biochemistry, Memorial University of Newfoundland, St John s, Newfoundland, A1B 3X9 Canada
    J Agric Food Chem 50:477-83. 2002
    ..2-26.8 to 37.4-39.9% (after 24 h). The highest EPA incorporations of 39.9 and 37.4% in BO and EPO, respectively, occurred at the stoichiometric mole ratio of 1:3 for oil to EPA...
  38. ncbi The effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandin synthesis in older subjects
    A Hornych
    Broussais Hospital, Paris, France
    Bratisl Lek Listy 103:101-7. 2002
    ..Epogam treatment also increased the biosynthesis of renal prostaglandins, especially that of prostaglandin E2, which has a vasodilatory effect on vessel walls and reduces the elevated blood pressure...
  39. ncbi Constituents in evening primrose oil with radical scavenging, cyclooxygenase, and neutrophil elastase inhibitory activities
    Matthias Hamburger
    Institute of Pharmacy, Friedrich Schiller University Jena, Semmelweisstrasse 10, Germany
    J Agric Food Chem 50:5533-8. 2002
    ..Commercial samples of evening primrose oils contained only traces of these lipophilic antioxidants...
  40. ncbi Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats
    Cai Song
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Canada C1A 4P3
    J Nutr 138:954-63. 2008
    ..01). AA did not counteract any of the changes induced by IL-1. These results suggest that EPA, GLA, and AA play different roles in the neuroendocrine-immune network...
  41. pmc Doctor accused of giving false information to drug trial
    Owen Dyer
    BMJ 325:618. 2002
  42. ncbi Pilot study of dietary fatty acid supplementation in the treatment of adult periodontitis
    Elliot D Rosenstein
    Arthritis and Rheumatic Disease Center, St Barnabas Medical Center, 200 South Orange Avenue, Livingston, NJ 07039, USA
    Prostaglandins Leukot Essent Fatty Acids 68:213-8. 2003
    ..Additional studies will be necessary to more fully assess the potential of these agents to favorably affect periodontal inflammation...
  43. ncbi Gamma-linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs
    S Chung
    Department of Medical Nutrition, Graduate School of East West Medical Science, Kyung Hee University, Seoul, Korea
    J Nutr 132:3090-7. 2002
    ..With primary dependence on absolute levels, our data demonstrate that the antiproliferative efficacy of GLA in the epidermis is preferably exerted from sn-2 stereospecificity of GLA in BO...
  44. ncbi Golden nail pigmentation
    Girish K Patel
    J Dermatolog Treat 13:41-2. 2002
  45. ncbi Botanicals and dietary supplements in diabetic peripheral neuropathy
    Kathleen M Halat
    California College of Podiatric Medicine, San Francisco, Calif, USA
    J Am Board Fam Pract 16:47-57. 2003
    ..As such, patients might turn to botanicals and dietary supplements, not realizing that these products are not well regulated...
  46. ncbi Effects of dietary linseed, evening primrose or fish oils on fatty acid and prostaglandin E2 contents in the rat livers and 7,12-dimethylbenz[a]anthracene-induced tumours
    Małgorzata Jelińska
    Department of Bromatology, Faculty of Pharmacy, The Medical University of Warsaw, Banacha 1, 02 097, Warsaw, Poland
    Biochim Biophys Acta 1637:193-9. 2003
    ..Both liver and tumour PGE2 contents were clearly correlated to the diet. The PGE2 concentrations were decreased in livers and tumours of rats fed fish (FO) and linseed oils (LO)...
  47. ncbi Inhibition of leukotriene synthesis, pharmacokinetics, and tolerability of a novel dietary fatty acid formulation in healthy adult subjects
    Marc E Surette
    Department of Research and Development, Pilot Therapeutics Inc, Charleston, South Carolina, USA
    Clin Ther 25:948-71. 2003
    ....
  48. ncbi Influence of formulas with borage oil or borage oil plus fish oil on the arachidonic acid status in premature infants
    H Demmelmair
    Kinderklinik and Kinderpoliklinik, Dr. von Haunersches Kinderspital, Ludwig-Maximilians University, Munich, Germany
    Lipids 36:555-66. 2001
    ..The effect of GLA on AA is independent of the EPA and DHA content in the diet within the dose ranges studied...
  49. ncbi Is there clinical evidence supporting the use of botanical dietary supplements in children?
    Andrea Hrastinger
    Institut fuer Pharmakognosie, Karl Franzens Universitaet Graz, Austria
    J Pediatr 146:311-7. 2005
  50. ncbi Positional distribution of FA in TAG of enzymatically modified borage and evening primrose oils
    S P J Namal Senanayake
    Department of Biochemistry, Memorial University of Newfoundland, St John s, Canada
    Lipids 37:803-10. 2002
    ..In (EPA + DHA)-enriched EPO, GLA was mainly located at the sn-2 and -3 positions; EPA was preferentially esterified at the sn-1 and -3 positions, and DHA was found mainly at the sn-3 position...
  51. ncbi Topical nonsteroidal anti-inflammatory drugs versus oil of evening primrose in the treatment of mastalgia
    S Qureshi
    Department of Surgery Surgical Unit 11, Dow Medical College and Civil Hospital, Karachi, Pakistan
    Surgeon 3:7-10. 2005
    ..To compare oil of evening primrose (OEP) and topical nonsteroidal anti-inflammatory (NSAIDs) with respect to safety, effectiveness, rapidity of response, cost effectiveness and acceptability in the treatment of breast pain...
  52. ncbi [Study on the encapsulation technique of high purity gamma-linolenic acid, part 1--saponification reaction and saponification value]
    Feng xia Liu
    Central China University of Science and Technology, Wuhan 430074, China
    Zhongguo Zhong Yao Za Zhi 30:343-6. 2005
    ....
  53. ncbi [Study on the encapsulation technique of high purity gamma-linolenic acid, part 1--Single factor, and two-factor tests for encapsulation process]
    Feng xia Liu
    Central China University of Science and Technology, Wuhan 430074, China
    Zhongguo Zhong Yao Za Zhi 30:433-5. 2005
    ..To study the effects of all factors during the process of urea encapsulation of gamma-linolenic acid on the purity and yield...
  54. ncbi Black currant seed oil and fish oil supplements differ in their effects on fatty acid profiles of plasma lipids, and concentrations of serum total and lipoprotein lipids, plasma glucose and insulin
    Raija L Tahvonen
    Department of Biochemistry and Food Chemistry, University of Turku, 20014 Turku, Finland
    J Nutr Biochem 16:353-9. 2005
    ..Serum levels of LDL cholesterol were lower (P<.05) after black currant seed oil compared to fish oil. Plasma glucose concentration decreased during the fish oil supplementation (P<.05)...
  55. pmc The effects of evening primrose oil on nerve function and capillarization in streptozotocin-diabetic rats: modulation by the cyclo-oxygenase inhibitor flurbiprofen
    N E Cameron
    Department of Biomedical Sciences, University of Aberdeen, Marischal College
    Br J Pharmacol 109:972-9. 1993
    ..Sixth, evening primrose oil probably acts by providing substrate for vasodilator prostanoid synthesis by vasa nervorum...
  56. ncbi Dietary fish and evening primrose oil with vitamin E effects on semen variables in cockerels
    S Cerolini
    Dipartimento di Scienze e Tecnologie Veterinarie per la Sicurezza Alimentare, Universita di Milano, Milano, Italy
    Br Poult Sci 46:214-22. 2005
    ..The proportion of motile spermatozoa was improved by the increased supplementation of vitamin E in all oil treatments...
  57. ncbi Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind study
    Marieke O Verhoeven
    Project Ageing Women, Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands
    Menopause 12:412-20. 2005
    ..To investigate the effects of a novel dietary supplement containing soy isoflavones and Actaea racemosa Linnaeus (formerly called Cimicifuga racemosa L.) on climacteric symptoms in healthy perimenopausal women...
  58. ncbi Advances in nondietary management of children with atopic dermatitis
    J E Rasmussen
    Department of Dermatology, University of Michigan, Ann Arbor 48109-0314
    Pediatr Dermatol 6:210-5. 1989
    ..This is important because AD does not last forever, and in many patients, mild disease heals spontaneously...
  59. ncbi A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia
    Amit Goyal
    Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Breast J 11:41-7. 2005
    ..This study showed that GLA (Efamast) efficacy did not differ from that of placebo fatty acids, regardless of whether or not antioxidant vitamins were present...
  60. ncbi Who and how many people are taking herbal supplements? A survey of 21,923 adults
    Roger A Harrison
    Bolton Primary Care Trust, St Peter s House, Silverwell Street, Bolton BL1 1PP, England
    Int J Vitam Nutr Res 74:183-6. 2004
    ..There is little information on the number and characteristics of adults taking herbal supplements and the relationship of this with other health and lifestyle factors. These were examined in the current study...
  61. ncbi The safety of evening primrose oil in epilepsy
    B K Puri
    Imaging Sciences Department, MRC Clinical Sciences Centre, Faculty of Medicine, Hammersmith Campus, Imperial College London, London, UK
    Prostaglandins Leukot Essent Fatty Acids 77:101-3. 2007
    ....
  62. ncbi Fat facts and fallacies
    Jody L Vogelzang
    JLV and Associates, Southlake, TX 76092, USA
    Home Healthc Nurse 21:725-7. 2003
  63. ncbi Effects of different dietary oils on inflammatory mediator generation and fatty acid composition in rat neutrophils
    R De la Puerta Vazquez
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain
    Metabolism 53:59-65. 2004
    ..67 ng/mL compared with 26.69 ng/mL from BD). These experimental data suggest that FO and PO, as well as VOO, could be considered a valuable strategy in preventing the generation of some inflammatory mediators...
  64. ncbi Dietary gamma-linolenic acid suppresses aortic smooth muscle cell proliferation and modifies atherosclerotic lesions in apolipoprotein E knockout mice
    Y Y Fan
    Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University, College Station, Texas 77840, USA
    J Nutr 131:1675-81. 2001
    ..05) atherosclerotic lesion size in 30-wk-old mice. These results indicate that dietary GLA can suppress smooth muscle cell proliferation in vivo and retard the development of diet-induced atherosclerosis in apoE knockout mice...
  65. pmc Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma
    Vincent A Ziboh
    Division of Rheumatology, Allergy and Clinical Immunology, Department of Dermatology, University of California at Davis School of Medicine, TB 192, Davis, CA 95616, USA
    Clin Dev Immunol 11:13-21. 2004
    ..Nonetheless, the study demonstrated dietary fatty acid modulation of endogenous inflammatory mediators without side effects and thus warrant further explorations into the roles of GLA at higher doses, leukotrienes and asthma...
  66. pmc A randomised cross-over trial in healthy adults indicating improved absorption of omega-3 fatty acids by pre-emulsification
    Iveta Garaiova
    Obsidian Research Ltd, Baglan, Port Talbot, UK
    Nutr J 6:4. 2007
    ..In this study the levels of plasma fatty acid and triacylglycerol (TAG) following the ingestion of either an oil mixture or an emulsified oil mixture have been compared...
  67. ncbi Prevention and partial reversal of diabetes-induced changes in enteric nerves of the rat ileum by combined treatment with alpha-lipoic acid and evening primrose oil
    Hannah R Shotton
    Department of Anatomy and Developmental Biology, Autonomic Neuroscience Institute, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Auton Neurosci 111:57-65. 2004
    ..Therefore, LA and EPO are only effective at treating diabetes-induced changes in some enteric nerves when administered in combination. However, diabetes-induced changes in NA-containing nerves are resistant to treatment...
  68. ncbi Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y
    F Thies
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 73:539-48. 2001
    ..CONCLUSION: A moderate amount of EPA but not of other n-6 or n-3 polyunsaturated fatty acids can decrease NK cell activity in healthy subjects...
  69. ncbi Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose oil
    Roland Knorr
    Institute of Pharmacy, Friedrich Schiller University Jena, Semmelweisstrasse 10, D 07743 Jena, Germany
    J Agric Food Chem 52:3319-24. 2004
    ..There was a difference between O. biennis and O. lamarckiana oils with respect to the relative amounts of the three esters. The temperature of the extraction process had no effect on the ratio of the compounds...
  70. ncbi Properties of cholesterol-reduced butter made with beta-cyclodextrin and added evening primrose oil and phytosterols
    J J Kim
    Department of Food Science and Technology, Sejong University, Seoul 143 747, Korea
    J Dairy Sci 89:4503-10. 2006
    ..However, the addition of EPO and phytosterols to the butter appeared to impair its sensory properties, especially in terms of rancidity and overall acceptability...
  71. ncbi Hot topic: Enhancing omega-3 fatty acids in milk fat of dairy cows by using stearidonic acid-enriched soybean oil from genetically modified soybeans
    G Bernal-Santos
    Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
    J Dairy Sci 93:32-7. 2010
    ....
  72. ncbi Investigation of gene expressions related to cholesterol metabolism in rats fed diets enriched in n-6 or n-3 fatty acid with a cholesterol after long-term feeding using quantitative-competitive RT-PCR analysis
    M Fukushima
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan
    J Nutr Sci Vitaminol (Tokyo) 47:228-35. 2001
    ....
  73. ncbi Selective modulation of the human platelet thromboxane A2/prostaglandin H2 receptor by eicosapentaenoic and docosahexaenoic acids in intact platelets and solubilized platelet membranes
    C A Parent
    Department of Pharmacology, University of Illinois, Chicago 60612
    J Biol Chem 267:6541-7. 1992
    ....
  74. ncbi The extract of Thujae occidentalis semen inhibited 5alpha-reductase and androchronogenetic alopecia of B6CBAF1/j hybrid mouse
    Won Seok Park
    Skin Research Team, Skin Research Institute, Amore Pacific Corporation R and D Center 314 1 Bora ri, Kiheung eup, Yongin si, Kyounggi Do, South Korea
    J Dermatol Sci 31:91-8. 2003
    ..Recent approach showed specific inhibitors for 5alpha-reductase type 2 such as finasteride promoted hair growth in male pattern alopecia...
  75. ncbi Dietary n-6 and n-3 fatty acids in immunity and autoimmune disease
    L S Harbige
    School of Chemical and Life Sciences, University of Greenwich, London, UK
    Proc Nutr Soc 57:555-62. 1998
    ....
  76. ncbi Polyunsaturated fatty acids induce tight junctions to form in brain capillary endothelial cells
    K Yamagata
    Division of Life Science, Graduate School of Integrated Science and Art, University of East Asia, Shimonoseki, Yamaguchi, Japan
    Neuroscience 116:649-56. 2003
    ..endothelial cells were grown to confluence on filters and exposed to eicosapentaenoic acids, gamma linolenic acid and linoleic acid. Transepithelial electrical resistance was determined with voltage-measuring electrodes...
  77. ncbi Influence of low-dose polyunsaturated fatty acids supplementation on the inflammatory response of healthy adults
    Ralf Schubert
    Department of Pediatrics, J W Goethe University, Frankfurt Main, Germany
    Nutrition 23:724-30. 2007
    ....
  78. ncbi Production of arachidonic acid and dihomo-gamma-linolenic acid from glycerol by oil-producing filamentous fungi, Mortierella in the ARS culture collection
    Ching T Hou
    Microbial Genomics and Bioprocessing Research Unit, National Center for Agricultural, Utilization Research, Agricultural Research Service, United States Department of Agriculture, 1815 North University Street, Peoria, IL 61604, USA
    J Ind Microbiol Biotechnol 35:501-6. 2008
    ..Time course studies showed that the maximum cell growth and AA production for both species were at 6 days of incubation. Therefore, glycerol can be considered for industrial use in the production of AA and DGLA...
  79. ncbi An anti-inflammatory and antioxidant nutritional supplement for hypoalbuminemic hemodialysis patients: a pilot/feasibility study
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    J Ren Nutr 15:318-31. 2005
    ..8 g/dL, a marker of malnutrition-inflammation complex syndrome, is observed in approximately half of all maintenance hemodialysis (MHD) patients in the United States and is strongly associated with increased mortality...
  80. ncbi Polyunsaturated but not conjugated linoleic acid supplementation of leukemic U937 cells can act as an amplification factor for photofrin-mediated photodynamic therapy
    Astrid Voigt
    Department of Pediatrics, Children s Hospital, Friedrich Schiller University of Jena, Germany
    Photochem Photobiol 82:763-9. 2006
    ..The results showed that PUFA, but not conjugated FA supplementation of U937 cells, can act as a PDT amplification factor...
  81. ncbi Metabolic diversity in biohydrogenation of polyunsaturated fatty acids by lactic acid bacteria involving conjugated fatty acid production
    Shigenobu Kishino
    Division of Applied Life Sciences, Laboratory of Fermentation Physiology and Applied Microbiology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Appl Microbiol Biotechnol 84:87-97. 2009
    ....
  82. pmc Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
    Lipids Health Dis 7:37. 2008
    ....
  83. ncbi Borage oil in the treatment of atopic dermatitis
    Rachel H Foster
    School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Nutrition 26:708-18. 2010
    ..Which patients are likely to respond cannot yet be identified. Borage oil is well tolerated in the short term but no long-term tolerability data are available...
  84. pmc Identification and functional analysis of the genes encoding Delta6-desaturase from Ribes nigrum
    Li Ying Song
    Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, China
    J Exp Bot 61:1827-38. 2010
    ....
  85. ncbi [Polyunsaturated fatty acid biogenesis is impaired in spontaneously hypertensive rat in relation to the pathogenesis of hypertension]
    M Narce
    , EA DGRT 1867, , Dijon
    Arch Mal Coeur Vaiss 89:1025-8. 1996
    ..Such results explain partly the effects of PUFA rich diets administered to hypertensive rats, and clarify the interpretation of such effects...
  86. ncbi Associations between term birth dimensions and prenatal exposure to essential and trans fatty acids
    Chantal E H Dirix
    Department of Human Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University Medical Centre, Maastricht, The Netherlands
    Early Hum Dev 85:525-30. 2009
    ..The aim of this study was to investigate associations between term birth dimensions and prenatal exposure to some of these fatty acids, reflected by neonatal fatty acid concentrations at birth...
  87. ncbi Essential fatty acids: biochemistry, physiology and pathology
    Undurti N Das
    UND Life Sciences, Shaker Heights, OH 44120, USA
    Biotechnol J 1:420-39. 2006
    ..Thus, EFAs and their derivatives have varied biological actions and seem to be involved in several physiological and pathological processes...
  88. ncbi Age-related changes in delta 6 and delta 5 desaturase activities in rat liver microsomes
    C Maniongui
    Unité de Recherche de Nutrition Cellulaire et Métabolique, Universite de Bourgogne, Dijon, France
    Lipids 28:291-7. 1993
    ..In particular, arachidonic acid content in old rats was slightly higher than in young rats whereas contents in linoleic and docosahexaenoic acids varied little throughout the life span.(ABSTRACT TRUNCATED AT 250 WORDS)..
  89. ncbi Fatty acids, the immune response, and autoimmunity: a question of n-6 essentiality and the balance between n-6 and n-3
    Laurence S Harbige
    School of Chemical and Life Sciences, University of Greenwich at Medway, Chatham Maritime, Kent ME4 4TB, United Kingdom
    Lipids 38:323-41. 2003
    ..Finally, the view that all n-6 PUFA are proinflammatory requires revision, in part, and their essential regulatory and developmental role in the immune system warrants appreciation...
  90. ncbi Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids
    Meagen M McCusker
    Department of Dermatology University of Connecticut Health Center, 263 Farmington Avenue, MC 6230, Farmington, CT 06030, USA
    Clin Dermatol 28:440-51. 2010
    ..They fulfill these functions independently and through the modulation of peroxisome proliferator-activated receptors and Toll-like receptors...
  91. pmc Serum phospholipid and cholesteryl ester fatty acids and estimated desaturase activities are related to overweight and cardiovascular risk factors in adolescents
    L M Steffen
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USA
    Int J Obes (Lond) 32:1297-304. 2008
    ..The objective of this study was to describe the relation of serum fatty acids and desaturase activity (DA) to overweight, insulin sensitivity and cardiovascular disease (CVD) risk factors in adolescents...
  92. ncbi Inhibitory effects of saturated and polyunsaturated fatty acids on the cytochrome P450 3A activity in rat liver microsomes
    Vilasinee Hirunpanich
    Faculty of Pharmacy, Mahasarakham University, Kantharavichai, Mahasarakham 44150, Thailand
    Biol Pharm Bull 30:1586-8. 2007
    ....
  93. pmc Usage patterns, health, and nutritional status of long-term multiple dietary supplement users: a cross-sectional study
    Gladys Block
    School of Public Health, 50 University Hall, University of California, Berkeley, CA, 94720, USA
    Nutr J 6:30. 2007
    ..This study describes the dietary supplement usage patterns, health, and nutritional status of long-term multiple dietary supplement users, and where possible makes comparisons to non-users and multivitamin/mineral supplement users...
  94. ncbi Effect of glutamate on arachidonic acid production from Mortierella alpina
    W Z Lan
    School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China
    Lett Appl Microbiol 35:357-60. 2002
    ..To evaluate the effect of glutamate on arachidonic acid production from Mortierella alpina...
  95. ncbi Effects of diet and simvastatin on fatty acid composition in hypercholesterolemic men: a randomized controlled trial
    Antti Jula
    Department of Health and Functional Capacity, National Public Health Institute of Finland, Turku, Finland
    Arterioscler Thromb Vasc Biol 25:1952-9. 2005
    ..To explore the separate and combined effects of simvastatin and a low-saturated diet rich in alpha-linolenic acid on serum fatty acids...
  96. ncbi Protective role of glucose-6-phosphate dehydrogenase activity in the metabolic response of C6 rat glioma cells to polyunsaturated fatty acid exposure
    Karina Lawrence Ramos
    Departamento de Histologia e Embriologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    Glia 43:149-66. 2003
    ....
  97. pmc Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2
    Ke He Ruan
    Department of Pharmacological and Pharmaceutical Sciences, The Center for Experimental Therapeutics and PharmacoInformatics, University of Houston, College of Pharmacy, Houston, TX 77030, USA
    Protein Eng Des Sel 22:733-40. 2009
    ..The COX-2-10aa-mPGES-1 hybrid enzyme engineering may be a novel approach in creating inflammation cell and animal models, which are particularly valuable targets for the next generation of NSAID screening...
  98. ncbi Substrate specificity of acyl-Delta(6)-desaturases from Continental versus Macaronesian Echium species
    Federico García-Maroto
    Area de Bioquímica, Facultad de Ciencias Experimentales, Universidad de Almeria, 04120 Almeria, Spain
    Phytochemistry 67:540-4. 2006
    ..Comparison among the amino acid sequences of these desaturases and other related enzymes, allowed us the discussion about the possible involvement of some specific positions in the determination of substrate specificity...
  99. ncbi Specific protein regions influence substrate specificity and product length in polyunsaturated fatty acid condensing enzymes
    Patricia L Vrinten
    Bioriginal Food and Science Corporation, 110 Gymnasium Place, Saskatoon, Saskatchewan, Canada S7N0W9
    Biochemistry 49:3879-86. 2010
    ..Thus, protein characteristics determined by specific luminal-proximal regions of fatty acid condensing enzymes have a major influence on substrate specificity and final product length...
  100. ncbi Effect of polyunsaturated fatty acids on diphenyl hydantoin-induced genetic damage in vitro and in vivo
    Shivani Ponnala
    Department of Genetics, Osmania University, Hyderabad 500 007, India
    Prostaglandins Leukot Essent Fatty Acids 80:43-50. 2009
    ..Based on these results we suggest that GLA functions as a unique endogenous molecule that protects cells from accumulating genetic damage...
  101. ncbi Lipids in the nutritional support of the critically ill patients
    Michel Hasselmann
    Service de Reanimation Medicale, Hopitaux Universitaires de Strasbourg, Hopital Civil, Strasbourg Cedex, France
    Curr Opin Crit Care 10:449-55. 2004
    ..It examines current knowledge of fatty acid safety, biologic effects, and the impact on patients' morbidity and mortality. The newly emerging area of genotypic influence and timing of immunonutrition is also discussed...

Research Grants19

  1. Modifiable Risk Factors for CME in Retinitis Pigmentosa
    Michael A Sandberg; Fiscal Year: 2010
    ..Since gamma linolenic acid (GLA) has also been suggested as a way to reduce edema, we will determine whether the risk of CME is ..
  2. ARDS - EDEN OMEGA Protocol
    TERRI HOUGH; Fiscal Year: 2011
    ....
  3. REGULATION AND FUNCTION OF CPLA2 IN UV INJURY
    Alice Pentland; Fiscal Year: 2000
    ..Knowledge of the role of cPLA2 in UV injury will greatly increase our understanding of the biology of cPLA2 as well as the mechanisms protecting the epidermis from environmental UV and other oxidative injuries. ..
  4. VASCULAR DISEASE IN DIABETIC NEUROPATHY
    Mark Yorek; Fiscal Year: 2003
    ..In summary, these studies will provide us with a better understanding of the etiology of DN and improved treatments for preventing the diabetes-induced changes in vascular and neural function. ..
  5. LINOLEIC ACID METABOLISM AND COLON CARCINOGENESIS
    Imad Shureiqi; Fiscal Year: 2005
    ..This work will set the stage for future animals and clinical studies of LA alternative pathway modulation as means of colon cancer chemoprevention. ..
  6. THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    ..abstract_text> ..
  7. Interaction of Nutrient & Organochlorine Absorption
    Patrick Tso; Fiscal Year: 2010
    ..The proposed research is important because of the biological and clinical importance of OCs in health and disease and they provide considerable new insights into how OCs are carried and delivered to the various organs in the body. ..
  8. Integration of Stress and Reproductive Axes by Dopamine
    Simon Evans; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. BORAGE OIL AND GINKGO BILOBA (EGb 761) IN ASTHMA
    MERRILL GERSHWIN; Fiscal Year: 2004
    ..It is hoped that findings from these studies will evolve relatively non-toxic therapeutic alternatives for attenuating bronchial hyperresponsiveness and inflammation in patients with asthma. ..
  10. Eighth Nerve Stimulation for the Treatment of ADHD
    L Arnold; Fiscal Year: 2003
    ..We hypothesize that CMA stimulation will show a larger effect than simple rotary stimulation, significant compared to sham control. Sufficient sample size is assured by the Ohio State University's recruitment record. ..
  11. Prostaglandin I synthase, Thromboxane A synthase & Prostaglandin E synthase
    Ke He Ruan; Fiscal Year: 2009
    ....
  12. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. Genetic modification of PUFA biosynthesis and CHD
    Ana Baylin; Fiscal Year: 2008
    ..This strengthens evaluation of risk, and application to current dietary goals. The large number of SNPs proposed for final analysis will add to the resolution and power to identify the genes that underlie CHD. ..
  14. STRUCTURE & FUNCTION RELATIONSHIP: PROSTANOID RECEPTORS
    Ke He Ruan; Fiscal Year: 2008
    ..Determine the solution conformation of segments comprising the intracellular domains. ..
  15. Oxidative Damage in Smokers and Passive Smokers
    Gladys Block; Fiscal Year: 2003
    ..smokers 6) To determine the level of vitamin C required by smokers to attain the plasma vitamin C levels of non-smokers 7) To study the effect of supplemental vitamin C or antioxidant cocktail on other plasma antioxidants ..
  16. Vitamins, Breast Milk HIV Shedding and Child Health
    Eduardo Villamor; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  17. Nutritional/Inflammatory Evaluation of Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2005
    ....
  18. PILOT EXPLORATIONS OF ZINC EFFECTS IN ADHD
    L Arnold; Fiscal Year: 2007
    ..Outcome measures include parent/teacher-rated ADHD symptoms for phases 1&2, and amphetamine optimal dose for phase 3. Tissue zinc will be determined by 3 state-of-the-art assays. ..
  19. MODULATION OF INTESTINAL OBESITY SIGNALS
    Patrick Tso; Fiscal Year: 2004
    ..In addition, the apo A-IV knockout and transgenic animals will be used to determine if there is interaction between the lymph glucose and lymph apo A-IV signals. ..