dinoprostone

Summary

Summary: The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.

Top Publications

  1. pmc Regulation of immune responses by prostaglandin E2
    Pawel Kalinski
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 188:21-8. 2012
  2. ncbi The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment
    Alexander Greenhough
    Department of Cellular and Molecular Medicine, Cancer Research UK Colorectal Tumour Biology Group, University of Bristol, University Walk, Clifton, Bristol, UK
    Carcinogenesis 30:377-86. 2009
  3. ncbi Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells
    Pratima Sinha
    Department of Biological Sciences, University of Maryland Baltimore County, University of Maryland, Baltimore, Maryland 21250, USA
    Cancer Res 67:4507-13. 2007
  4. ncbi Prostaglandin E receptors
    Yukihiko Sugimoto
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 282:11613-7. 2007
  5. pmc Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
    Trista E North
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 447:1007-11. 2007
  6. pmc Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration
    Wolfram Goessling
    Harvard Stem Cell Institute, Cambridge, MA 02138, USA
    Cell 136:1136-47. 2009
  7. ncbi Prostaglandins as modulators of immunity
    Sarah G Harris
    Dept of Microbiology and the James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Trends Immunol 23:144-50. 2002
  8. ncbi PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment
    Natasa Obermajer
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 71:7463-70. 2011
  9. ncbi Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion
    Chengcan Yao
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Nat Med 15:633-40. 2009
  10. ncbi Lipid mediator class switching during acute inflammation: signals in resolution
    B D Levy
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Nat Immunol 2:612-9. 2001

Research Grants

Detail Information

Publications310 found, 100 shown here

  1. pmc Regulation of immune responses by prostaglandin E2
    Pawel Kalinski
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 188:21-8. 2012
    ..Targeting the production, degradation, and responsiveness to PGE(2) provides tools to modulate the patterns of immunity in a wide range of diseases, from autoimmunity to cancer...
  2. ncbi The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment
    Alexander Greenhough
    Department of Cellular and Molecular Medicine, Cancer Research UK Colorectal Tumour Biology Group, University of Bristol, University Walk, Clifton, Bristol, UK
    Carcinogenesis 30:377-86. 2009
    ....
  3. ncbi Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells
    Pratima Sinha
    Department of Biological Sciences, University of Maryland Baltimore County, University of Maryland, Baltimore, Maryland 21250, USA
    Cancer Res 67:4507-13. 2007
    ....
  4. ncbi Prostaglandin E receptors
    Yukihiko Sugimoto
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 282:11613-7. 2007
    ..Here we review recent advances in PGE receptor research...
  5. pmc Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
    Trista E North
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 447:1007-11. 2007
    ..The conserved role for PGE2 in the regulation of vertebrate HSC homeostasis indicates that modulation of the prostaglandin pathway may facilitate expansion of HSC number for therapeutic purposes...
  6. pmc Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration
    Wolfram Goessling
    Harvard Stem Cell Institute, Cambridge, MA 02138, USA
    Cell 136:1136-47. 2009
    ..Our work provides in vivo evidence that Wnt activation in stem cells requires PGE2, and suggests the PGE2/Wnt interaction is a master regulator of vertebrate regeneration and recovery...
  7. ncbi Prostaglandins as modulators of immunity
    Sarah G Harris
    Dept of Microbiology and the James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Trends Immunol 23:144-50. 2002
    ..Understanding the diverse activities of these prostaglandins is crucial for the development of new therapies aimed at immune modulation...
  8. ncbi PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment
    Natasa Obermajer
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 71:7463-70. 2011
    ..Together, our findings elucidate a central role for PGE(2) in MDSC accumulation triggered by the CXCL12-CXCR4 pathway, providing a powerful rationale to target PGE(2) signaling in ovarian cancer therapy...
  9. ncbi Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion
    Chengcan Yao
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Nat Med 15:633-40. 2009
    ..Thus, PGE2-EP4 signaling promotes immune inflammation through TH1 differentiation and TH17 expansion, and EP4 antagonism may be therapeutically useful for various immune diseases...
  10. ncbi Lipid mediator class switching during acute inflammation: signals in resolution
    B D Levy
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Nat Immunol 2:612-9. 2001
    ....
  11. pmc Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E₂ and prostaglandin E₂ receptors
    Tripti Singh
    Department of Dermatology, University of Alabama at Birmingham, 35294, USA
    Carcinogenesis 32:86-92. 2011
    ..Together, these results indicate for the first time that berberine inhibits melanoma cell migration, an essential step in invasion and metastasis, by inhibition of COX-2, PGE₂ and PGE₂ receptors...
  12. pmc Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling
    Katia Boniface
    Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Exp Med 206:535-48. 2009
    ..These findings, together with the altered IL-12/IL-23 balance induced by PGE2 in dendritic cells, further highlight the crucial role of the inflammatory microenvironment in Th17 cell development and regulation...
  13. pmc Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration
    Fang Li
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Sci Signal 3:ra13. 2010
    ..We propose to call the pathway by which executioner caspases in apoptotic cells promote wound healing and tissue regeneration in multicellular organisms the "phoenix rising" pathway...
  14. pmc Prostaglandins and cancer
    D Wang
    The Vanderbilt Ingram Cancer Center, Room 698, Preston Research Building, 2300 Pierce Ave, Nashville, Tennessee 37232 6838, USA
    Gut 55:115-22. 2006
    ..Recent efforts to identify the molecular mechanisms by which PGE(2) promotes tumour growth and metastasis may provide opportunities for the development of safer strategies for cancer prevention and treatment...
  15. pmc Prostaglandin E(2) (PGE (2)) suppresses natural killer cell function primarily through the PGE(2) receptor EP4
    Dawn Holt
    Department of Pathology, School of Medicine, University of Maryland, Baltimore, USA
    Cancer Immunol Immunother 60:1577-86. 2011
    ....
  16. pmc The role of COX-2 in intestinal inflammation and colorectal cancer
    D Wang
    Department of Cancer Biology and GI Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Oncogene 29:781-8. 2010
    ....
  17. pmc Prostaglandin E2 and the pathogenesis of pulmonary fibrosis
    Paul D Bozyk
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Am J Respir Cell Mol Biol 45:445-52. 2011
    ..This review highlights these recent advances and offers new insights into the potential ways that PGE(2) and its downstream signals can be regulated for therapeutic benefit in a disease that has no validated treatment options...
  18. pmc Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis
    Yoshiyasu Esaki
    Departments of Pharmacology and Anesthesiology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 107:12233-8. 2010
    ....
  19. pmc Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2
    O Morteau
    Department of Medicine, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 105:469-78. 2000
    ....
  20. ncbi Prostaglandin E2 promotes degranulation-independent release of MCP-1 from mast cells
    Takayuki Nakayama
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Leukoc Biol 79:95-104. 2006
    ..These observations identify PGE2-induced MCP-1 release from MCs as a pathway underlying inflammation-associated angiogenesis and extend current understanding of the activities of PGE2...
  21. pmc Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells
    Natasa Obermajer
    Department of Surgery, University of Pittsburgh, Hillman Cancer Center, UPCI Research Pavilion, 5117 Center Ave, Pittsburgh, PA 15213 1863, USA
    Blood 118:5498-505. 2011
    ..The central role of COX2-PGE(2) feedback in the induction and persistence of MDSCs highlights the potential for its manipulation to enhance or suppress immune responses in cancer, autoimmunity, or transplantation...
  22. ncbi Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer
    Sherven Sharma
    Department of Medicine, Lung Cancer Research Program, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1960, USA
    Cancer Res 65:5211-20. 2005
    ..Transfer of Treg cells or administration of PGE2 to mice receiving COX-2 inhibitors reversed these effects. We conclude that inhibition of COX-2/PGE2 suppresses Treg cell activity and enhances antitumor responses...
  23. ncbi Membrane prostaglandin E synthase-1: a novel therapeutic target
    Bengt Samuelsson
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden
    Pharmacol Rev 59:207-24. 2007
    ..These findings indicate that mPGES-1 is a potential target for the development of therapeutic agents for treatment of several diseases...
  24. pmc Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion
    Dilprit Bagga
    Division of Hematology Oncology, Department of Obstetrics and Gynecology, University of California, Los Angeles, CA 90095 1679, USA
    Proc Natl Acad Sci U S A 100:1751-6. 2003
    ..Taken together, our data suggest that successful replacement of omega-6 PUFA with omega-3 PUFA in cell membranes can result in a decreased cellular response to mitogenic and inflammatory stimuli...
  25. ncbi Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis
    Howard F Tiano
    Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 62:3395-401. 2002
    ..Thus, both COX-1 and COX-2 have roles in keratinocyte differentiation, and we propose that the absence of either isoform causes premature terminal differentiation of initiated keratinocytes and reduced tumor formation...
  26. ncbi PGE2 inhibits natural killer and gamma delta T cell cytotoxicity triggered by NKR and TCR through a cAMP-mediated PKA type I-dependent signaling
    Ludovic Martinet
    INSERM, U 563, Centre de Physiopathologie de Toulouse Purpan, Toulouse F 31300, France
    Biochem Pharmacol 80:838-45. 2010
    ..In the discussion, we focused on how these data should impact particular approaches in the treatment of cancer...
  27. pmc Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion
    Carlo Chizzolini
    Division of Immunology and Allergy, Department of Internal Medicine, University Hospital and School of Medicine, Geneva, Switzerland
    Blood 112:3696-703. 2008
    ....
  28. pmc Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4
    Gabriel L Galea
    School of Veterinary Sciences, University of Bristol, Bristol, United Kingdom
    FEBS Lett 585:2450-4. 2011
    ..These findings indicate early divergence in the signaling pathways stimulated by strain and establish PGE2/EP4 as the pathway used by strain to regulate Sost expression...
  29. ncbi Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells
    Felicita Baratelli
    Lung Cancer Research Program of the Jonsson Comprehensive Cancer Center and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 175:1483-90. 2005
    ..Finally, PGE2 up-regulated FOXP3 at both mRNA and protein levels and enhanced FOXP3 promoter activity. This is the first report indicating that PGE2 can modulate FOXP3 expression and T reg function in human lymphocytes...
  30. ncbi Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma
    Augusto C Ochoa
    Stanley S Scott Cancer Center and Department of Pediatrics, Louisiana State University Health Sciences Center, 533 Bolivar Street, New Orleans, LA 70112, USA
    Clin Cancer Res 13:721s-726s. 2007
    ..Preliminary data suggest that prostaglandin E(2) produced by the tumor induces arginase I expression in MDSC. Therefore, blocking MDSC activity may enhance the therapeutic efficacy of immunotherapy in RCC...
  31. ncbi Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity
    T A Samad
    Department of Anatomy, University College London, London WC1E 6BT, UK
    Nature 410:471-5. 2001
    ..Thus, preventing central prostanoid production by inhibiting the interleukin-1beta-mediated induction of Cox-2 in neurons or by inhibiting central Cox-2 activity reduces centrally generated inflammatory pain hypersensitivity...
  32. ncbi Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases
    Jean Y Park
    The Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Clin Immunol 119:229-40. 2006
    ..In this review, we summarize the synthesis and secretion of PGE2. In particular, we focus on the three isoforms of the terminal PGES, and discuss the potential of targeting PGES as a more precise strategy for inhibiting PGE2 production...
  33. ncbi Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo
    Kathleen M Leahy
    Pharmacia, Mail Zone AA4C, 700 Chesterfield Parkway, Chesterfield, Missouri 63017, USA
    Cancer Res 62:625-31. 2002
    ..2-3.0-fold) in response to celecoxib. Thus, the antitumor activity of celecoxib may be attributable, at least in part, to a direct effect on host stromal elements, such as the angiogenic vasculature...
  34. ncbi Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer
    Mariam Dohadwala
    Lung Cancer Research Program of the University of California at Los Angeles Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Cancer Res 66:5338-45. 2006
    ..Thus, blocking PGE(2) production or activity may contribute to both prevention and treatment of NSCLC...
  35. ncbi Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
    S G Morham
    Department of Pathology, University of North Carolina at Chapel Hill 27599 7525, USA
    Cell 83:473-82. 1995
    ..Mice lacking COX-2 have normal inflammatory responses to treatments with tetradecanoyl phorbol acetate or with arachidonic acid. However, they develop severe nephropathy and are susceptible to peritonitis...
  36. pmc Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine
    Masayuki Fukata
    Inflammatory Bowel Disease Center, Division of Gastroenterology, New York, New York, USA
    Gastroenterology 131:862-77. 2006
    ..We wished to test the hypothesis that cyclooxygenase 2 (Cox-2)-derived prostaglandin E2 (PGE2) is important in TLR4-related mucosal repair...
  37. pmc Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling
    Alexandra I Medeiros
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
    J Exp Med 206:61-8. 2009
    ..They also identify an opportunity to reduce the incidence and severity of pneumonia in the setting of lung injury by pharmacologically targeting synthesis of PGE(2) or ligation of EP2...
  38. ncbi Prostaglandin E2, an immunoactivator
    Daiji Sakata
    Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
    J Pharmacol Sci 112:1-5. 2010
    ..In this perspective, we review these findings and discuss the prospect of EP4 antagonists as immunomodulatory drugs...
  39. pmc The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
    Kenji Kabashima
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    J Clin Invest 109:883-93. 2002
    ..We conclude that EP4 maintains intestinal homeostasis by keeping mucosal integrity and downregulating immune response...
  40. ncbi Identification and characterization of a novel type of membrane-associated prostaglandin E synthase
    Naomi Tanikawa
    Special Division for Human Life Technology, Cell Dynamics Research Group, National Institute of AIST, Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Biochem Biophys Res Commun 291:884-9. 2002
    ....
  41. pmc Prostaglandin E2 promotes lung cancer cell migration via EP4-betaArrestin1-c-Src signalsome
    Jae Il Kim
    Department of Pathology, Medical College of Georgia, Augusta, Georgia, USA
    Mol Cancer Res 8:569-77. 2010
    ..Selective targeting of EP4 with a ligand antagonist may provide an efficient approach to better manage patients with advanced lung cancer...
  42. ncbi Lipopolysaccharide induces macrophage migration via prostaglandin D(2) and prostaglandin E(2)
    Tsuyoshi Tajima
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Pharmacol Exp Ther 326:493-501. 2008
    ....
  43. ncbi Production of PGE(2) increases in tendons subjected to repetitive mechanical loading and induces differentiation of tendon stem cells into non-tenocytes
    Jianying Zhang
    MechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Orthop Res 28:198-203. 2010
    ....
  44. ncbi Recruitment and activation of natural killer cells in vitro by a human dendritic cell vaccine
    Karin Gustafsson
    Department of Neuroscience and Physiology, Goteborg University, Goteborg, Sweden
    Cancer Res 68:5965-71. 2008
    ....
  45. pmc Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death
    Minjian Chen
    Department of Medicine, Division of Rheumatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 205:2791-801. 2008
    ..These in vitro and in vivo data indicate that PGE(2) plays a critical role in inhibition of Mtb replication...
  46. pmc Aberrant PGE₂ metabolism in bladder tumor microenvironment promotes immunosuppressive phenotype of tumor-infiltrating myeloid cells
    Evgeniy Eruslanov
    Department of Urology, University of Florida, College of Medicine, Gainesville, FL 32610, USA
    Int Immunopharmacol 11:848-55. 2011
    ....
  47. ncbi The cardinal role of the phospholipase A(2)/cyclooxygenase-2/prostaglandin E synthase/prostaglandin E(2) (PCPP) axis in inflammostasis
    A D Mancini
    Department of Anatomy and Cell Biology, McGill University, 3640 University St, Montreal, QC H3A 2B2, Canada
    Inflamm Res 60:1083-92. 2011
    ....
  48. pmc Tumor-secreted PGE2 inhibits CCL5 production in activated macrophages through cAMP/PKA signaling pathway
    Xuesong Qian
    Division of Immunobiology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 286:2111-20. 2011
    ....
  49. pmc Prostaglandin E2 regulates renal cell carcinoma invasion through the EP4 receptor-Rap GTPase signal transduction pathway
    Juanjuan Wu
    Department of Pathology, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    J Biol Chem 286:33954-62. 2011
    ..These results support the idea that targeted inhibition of EP4 signaling and restoration of Rap1GAP expression constitute a new strategy to control kidney cancer progression...
  50. ncbi Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice
    P C Chulada
    Laboratory of Experimental Carcinogenesis and Mutagenesis, NIH, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 60:4705-8. 2000
    ..The results indicate that COX-1, as well as COX-2, plays a key role in intestinal tumorigenesis and that COX-1 may also be a chemotherapeutic target for nonsteroidal anti-inflammatory drugs...
  51. ncbi Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis
    T Tanioka
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Biol Chem 275:32775-82. 2000
    ..Thus, functional coupling between COX-1 and cPGES/p23 may contribute to production of the PGE(2) that plays a role in maintenance of tissue homeostasis...
  52. ncbi Protective effects of DIDS against ethanol-induced gastric mucosal injury in rats
    Wei Zhao
    Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Institutes of Medical Sciences, Department of Pathology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Acta Biochim Biophys Sin (Shanghai) 41:301-8. 2009
    ..Our results suggested that DIDS is beneficial in rat model of gastric injury through mechanisms that involve inhibiting inflammatory cell infiltration and lipid peroxidation and up-regulating the COX-2/PGE2 pathway...
  53. ncbi Dietary grape seed proanthocyanidins inhibit 12-O-tetradecanoyl phorbol-13-acetate-caused skin tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated mouse skin, which is associated with the inhibition of inflammatory responses
    Syed M Meeran
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Carcinogenesis 30:520-8. 2009
    ..Together, our results show that dietary GSPs inhibit chemical carcinogenesis in mouse skin and that the inhibition of skin tumorigenesis by GSPs is associated with the inhibition of inflammatory responses caused by tumor promoters...
  54. ncbi Dendritic cells issued in vitro from bone marrow produce PGE(2) that contributes to the immunomodulation induced by antigen-presenting cells
    H Harizi
    Laboratoire d'Immunologie, , Bordeaux, Cedex, 33076, France
    Cell Immunol 209:19-28. 2001
    ....
  55. ncbi The lung as a privileged site for the beneficial actions of PGE2
    Carlo Vancheri
    Department of Internal and Specialistic Medicine, Section of Respiratory Diseases, University of Catania, Via Passo Gravina, 187, 95125, Catania, Italy
    Trends Immunol 25:40-6. 2004
    ....
  56. ncbi Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells
    Kenji Kabashima
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Nat Med 9:744-9. 2003
    ..PGE2-EP4 signaling thus facilitates initiation of skin immune responses by promoting the migration and maturation of Langerhans cells...
  57. pmc Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma
    L Chastine Bell-Parikh
    Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104 6084, USA
    J Clin Invest 112:945-55. 2003
    ..15d-PGJ2 is not the endogenous mediator of PPARgamma-dependent adipocyte activation and is unaltered in clinical settings in which PPARgamma activation has been implicated...
  58. pmc The role of prostaglandin E2 in the immunopathogenesis of experimental pulmonary tuberculosis
    Javier Rangel Moreno
    Experimental Pathology Section, Department of Pathology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Tlalpan, Mexico
    Immunology 106:257-66. 2002
    ....
  59. ncbi The role and regulation of COX-2 during viral infection
    Sarah A Steer
    Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA
    Viral Immunol 16:447-60. 2003
    ....
  60. ncbi A critical role for prostaglandin E2 in podosome dissolution and induction of high-speed migration during dendritic cell maturation
    Suzanne F G van Helden
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Immunol 177:1567-74. 2006
    ..Together, these results show that maturation-induced podosome dissolution and loss of alpha(5)beta(1) integrin activity allow human DCs to undergo the transition from an adhesive to a highly migratory phenotype...
  61. ncbi Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP
    David M Aronoff
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0642, USA
    J Immunol 173:559-65. 2004
    ..Our data support a negative regulatory role for PGE(2) on the antimicrobial activity of AMs, which has important implications for future efforts to prevent and treat bacterial pneumonia...
  62. ncbi Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1
    Ryo Fukuda
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Cancer Res 63:2330-4. 2003
    ..Thus, the activity of multiple signal transduction pathways is required for the HIF-1-mediated induction of VEGF expression in colon cancer cells exposed to PGE(2)...
  63. pmc Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse
    C Nataraj
    Division of Nephrology, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC 27705, USA
    J Clin Invest 108:1229-35. 2001
    ....
  64. pmc Human mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responses
    Chunli Feng
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Blood 107:3243-50. 2006
    ..These functions explain the potency of PGE2 as a suppressor of early- and late-phase allergic responses...
  65. pmc Prostaglandin E(2) induces fibroblast apoptosis by modulating multiple survival pathways
    Steven K Huang
    Pulmonary and Critical Care Medicine, University of Michigan, 6301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, MI 48109 5642, USA
    FASEB J 23:4317-26. 2009
    ..They provide another dimension by which PGE(2) may inhibit, and perhaps even reverse, fibrogenesis in patients with interstitial lung disease...
  66. ncbi The induction of IL-10 by zymosan in dendritic cells depends on CREB activation by the coactivators CREB-binding protein and TORC2 and autocrine PGE2
    Yolanda Alvarez
    Instituto de Biologia y Genetica Molecular, Consejo Superior de Investigaciones Cientificas, Valladolid, Spain
    J Immunol 183:1471-9. 2009
    ....
  67. ncbi Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis
    Maria Domenica Castellone
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4340, USA
    Science 310:1504-10. 2005
    ..These findings may provide a molecular framework for the future evaluation of chemopreventive strategies for colorectal cancer...
  68. ncbi Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia
    Abderrahmane Kaidi
    Cancer Research UK Colorectal Tumour Biology Research Group, Department of Cellular and Molecular Medicine, Faculty of Medical and Veterinary Science, Bristol University, Bristol BS8 1TD, United Kingdom
    Cancer Res 66:6683-91. 2006
    ..We propose that using modified COX-2-selective inhibitors, which are only activated under hypoxic conditions, could potentially be a novel more selective strategy for colorectal cancer prevention and treatment...
  69. pmc Prostaglandin E₂-EP4 signaling suppresses adipocyte differentiation in mouse embryonic fibroblasts via an autocrine mechanism
    Tomoaki Inazumi
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Lipid Res 52:1500-8. 2011
    ....
  70. ncbi Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances
    Daniel F Legler
    Biotechnology Institute Thurgau BITg at the University of Konstanz, Unterseestrasse 47, Kreuzlingen, Switzerland
    Int J Biochem Cell Biol 42:198-201. 2010
    ..Therefore, pharmacological inhibition of COX enzymes and PGE(2) receptor antagonism is of great therapeutic interest...
  71. pmc COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells
    Mitsugu Fujita
    Brain Tumor Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Cancer Res 71:2664-74. 2011
    ..Taken together, our findings show that the COX-2 pathway promotes gliomagenesis by directly supporting systemic development of MDSCs and their accumulation in the TME, where they limit CTL infiltration...
  72. ncbi Cyclooxygenase-2-issued prostaglandin e(2) enhances the production of endogenous IL-10, which down-regulates dendritic cell functions
    Hedi Harizi
    Laboratoire d Immunologie, Unité Mixte de Recherche Centre National de la Recherche Scientifique, Universite Victor Segalen, Bordeaux 2, 33076 Bordeaux, France
    J Immunol 168:2255-63. 2002
    ..We conclude that COX-2-mediated PGE(2) up-regulates IL-10, which down-regulates IL-12 production and the APC function of BM-DC...
  73. ncbi Adenosine analogs and electromagnetic fields inhibit prostaglandin E2 release in bovine synovial fibroblasts
    M de Mattei
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Osteoarthritis Cartilage 17:252-62. 2009
    ..To investigate the role of adenosine analogs and electromagnetic field (EMF) stimulation on prostaglandin E(2) (PGE(2)) release and cyclooxygenase-2 (COX-2) expression in bovine synovial fibroblasts (SFs)...
  74. ncbi IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells
    P Kalinski
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Immunol 159:28-35. 1997
    ..Since type 2 Th responses are protective in several Th1-related autoimmune disorders, PGE2-DC may be considered for use in immunotherapy...
  75. pmc Prostaglandin E(2) couples through EP(4) prostanoid receptors to induce IL-8 production in human colonic epithelial cell lines
    I Dey
    Departments of Microbiology and Infectious Diseases, Health Sciences Centre, University of Calgary, AB, Canada
    Br J Pharmacol 156:475-85. 2009
    ..The aim of this study was to identify the role of the EP(2) and EP(4) receptor subtype(s) on two human colonic epithelial cell lines (Caco-2 and T84), in regulating PGE(2)-induced IL-8 production...
  76. ncbi Effect of high and low sodium intake on urinary aquaporin-2 excretion in healthy humans
    Carolina Cannillo Graffe
    Dept of Medical Research, Holstebro Hospital, Holstebro, Denmark
    Am J Physiol Renal Physiol 302:F264-75. 2012
    ..In conclusion, u-AQP2 was increased during HS intake, indicating that water transport via AQP2 was increased. The effect was mediated by an unknown AVP-independent mechanism...
  77. pmc Prostaglandins in bone: bad cop, good cop?
    Katherine A Blackwell
    New England Musculoskeletal Institute, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT, USA
    Trends Endocrinol Metab 21:294-301. 2010
    ..Further analysis of COX-2 and PG receptors and their downstream G-protein signaling in bone could provide important clues to the regulation of skeletal cell growth in both health and disease...
  78. ncbi Periodontal disease increases the risk of severe pre-eclampsia among pregnant women
    Varol Canakci
    Department of Periodontology, School of Dentistry, Ataturk University, Erzurum, Turkey
    J Clin Periodontol 34:639-45. 2007
    ....
  79. ncbi 3-(4-(tert-Octyl)phenoxy)propane-1,2-diol suppresses inflammatory responses via inhibition of multiple kinases
    Tao Yu
    Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea
    Biochem Pharmacol 83:1540-51. 2012
    ..Therefore, this compound has the potential to be served as a lead chemical for developing a promising anti-inflammatory drug candidate with multiple kinase targets...
  80. pmc PGE2 promotes angiogenesis through EP4 and PKA Cγ pathway
    Yushan Zhang
    Urology and Prostate Disease Center, University of Florida College of Medicine, Gainesville, USA
    Blood 118:5355-64. 2011
    ..These results support the existence of EP4-to-PKA angiogenic signal and provide rationale for use of selective EP4 signal inhibitors as a probable strategy to control pathologic angiogenesis...
  81. ncbi The prostaglandin E2 receptor EP4 is expressed by human platelets and potently inhibits platelet aggregation and thrombus formation
    Sonia Philipose
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, A 8010 Graz, Austria
    Arterioscler Thromb Vasc Biol 30:2416-23. 2010
    ..The platelet-stimulating effect of PGE(2) has been suggested to involve EP3 receptors. Here we analyzed the receptor usage relating to the inhibitory effect of PGE(2)...
  82. pmc Prostaglandin E2 induces matrix metalloproteinase 9 expression in dendritic cells through two independent signaling pathways leading to activator protein 1 (AP-1) activation
    Jui Hung Yen
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 286:38913-23. 2011
    ..Our results describe a new molecular mechanism for the effect of PGE2 on MMP-9 production in DCs that could lead to future therapeutic approaches using ERK inhibitors to regulate DC migration...
  83. pmc Elevated expression of prostaglandin receptor and increased release of prostaglandin E2 maintain the survival of CD45RO+ T cells in the inflamed human pleural space
    Elisabetta Pace
    Istituto di Biomedicina e Immunologia Molecolare, Unità di Immunopatologia e Farmacologia Clinica e Sperimentale dell Apparato respiratorio, Consiglio Nazionale delle Ricerche, Palermo, Italy
    Immunology 121:427-36. 2007
    ....
  84. pmc Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma
    Agnes Rasmuson
    Childhood Cancer Research Unit, Department of Women s and Children s Health, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e29331. 2012
    ....
  85. ncbi Prostaglandin E2 induces hypertrophic changes and suppresses alpha-skeletal actin gene expression in rat cardiomyocytes
    Satoru Miyatake
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    J Cardiovasc Pharmacol 50:548-54. 2007
    ..In conclusion, PGE2 induced hypertrophic changes in cardiomyocytes and attenuated alpha-skeletal actin gene expression in part via EP4...
  86. ncbi Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway
    Hiroko Oshima
    Division of Genetics, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Gastroenterology 131:1086-95. 2006
    ..To investigate the role of Wnt and PGE(2) in gastric cancer, we have generated transgenic mice that activate both pathways and examined their phenotypes...
  87. ncbi Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, United States
    Mol Cell Endocrinol 332:306-13. 2011
    ..These novel findings provide an important molecular and cellular framework for further evaluation of selective inhibition of EP2 and EP4 as potential nonsteroidal therapy for endometriosis in childbearing-age women...
  88. ncbi Prostaglandin E2 induces vascular relaxation by E-prostanoid 4 receptor-mediated activation of endothelial nitric oxide synthase
    Ana Marija Hristovska
    Department of Physiology and Pharmacology, University of Southern Denmark, Odense, Denmark
    Hypertension 50:525-30. 2007
    ....
  89. ncbi ESAT-6 induced COX-2 expression involves coordinated interplay between PI3K and MAPK signaling
    Senthil Kumar A
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India
    Mol Immunol 49:655-63. 2012
    ..These findings would serve as a paradigm to understand pathogenesis of mycobacterial infection and clearly pave a way towards development of novel therapeutics...
  90. ncbi Francisella tularensis-infected macrophages release prostaglandin E2 that blocks T cell proliferation and promotes a Th2-like response
    Matthew D Woolard
    Department of Microbiology and Immunology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 178:2065-74. 2007
    ..From these data, we conclude that F. tularensis can alter host T cell responses by causing macrophages to produce PGE(2). This study defines a previously unknown mechanism used by F. tularensis to modulate adaptive immunity...
  91. ncbi PGE1 and PGE2 modify platelet function through different prostanoid receptors
    David Iyu
    Cardiovascular Medicine, University of Nottingham, Nottingham, UK
    Prostaglandins Other Lipid Mediat 94:9-16. 2011
    ..In both cases the overall effects on platelet function reflect the balance between promotory and inhibitory effects at receptors that have opposite effects on adenylate cyclase...
  92. ncbi β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells
    Helena J M Smartt
    Cancer Research UK Colorectal Tumour Biology Research Group, School of Cellular and Molecular Medicine, University Walk, University of Bristol, Bristol, UK
    Gut 61:1306-14. 2012
    ..As Wnt/β-catenin signalling is also deregulated early in colorectal neoplasia, a study was undertaken to determine whether β-catenin represses 15-PGDH expression...
  93. ncbi Activation of E-prostanoid4 and E-prostanoid2 receptors inhibits TNF-alpha release from human alveolar macrophages
    M J Ratcliffe
    Dept of Molecular Biology, AstraZeneca Research and Development Charnwood, Bakewell Road, Loughborough, LE11 5RH, UK
    Eur Respir J 29:986-94. 2007
    ..These data indicate that both E-prostanoid(4) and E-prostanoid(2) selective agonists may have anti-inflammatory properties in lung diseases where macrophages play a role...
  94. pmc A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation
    Leah L N Hubbard
    Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 184:6299-308. 2010
    ..Therefore, strategies to limit IRAK-M elevation post-BMT may be efficacious in reducing patient susceptibility to infection...
  95. ncbi Nitric oxide synthase 1 and cyclooxygenase-2 enzymes are targets of muscarinic activation in normal and inflamed NIH3T3 cells
    A J Español
    Centro de Estudios Farmacológicos y Botánicos CEFYBO CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 piso 16, Buenos Aires, CP 1121, Argentina
    Inflamm Res 59:227-38. 2010
    ..In this work, we investigate the action of the muscarinic agonist carbachol (CARB) on the expression and function of nitric oxide synthase (NOS) and cyclooxygenase (COX) in fibroblasts under normal or inflammatory conditions...
  96. ncbi Interaction of eosinophils with endothelial cells is modulated by prostaglandin EP4 receptors
    Viktoria Konya
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Eur J Immunol 41:2379-89. 2011
    ....
  97. ncbi Prostaglandin E2 plays a key role in the immunosuppressive properties of adipose and bone marrow tissue-derived mesenchymal stromal cells
    Rosa Yañez
    Hematopoiesis and Gene Therapy Division, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas andCentro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain
    Exp Cell Res 316:3109-23. 2010
    ..In conclusion, we propose that PGE2 is a soluble factor mediating most of the immunosuppressive effects of Ad-MSCs and BM-MSCs over p-DCs maturation and activated T lymphocytes proliferation and cytokine secretion...
  98. pmc Anti-inflammation therapy by activation of prostaglandin EP4 receptor in cardiovascular and other inflammatory diseases
    Eva H C Tang
    Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong
    J Cardiovasc Pharmacol 59:116-23. 2012
    ..Overall, EP4 activation produces powerful anti-inflammatory responses in many experimental diseases, rendering EP4 agonists attractive agents to attenuate syndromes associated with inflammation...
  99. pmc EP1 prostanoid receptor coupling to G i/o up-regulates the expression of hypoxia-inducible factor-1 alpha through activation of a phosphoinositide-3 kinase signaling pathway
    Ruyue Ji
    Department of Pharmacology and Toxicology, College of Pharmacy The University of Arizona, 1703 E Mabel St, Tucson, AZ 85721 0207, USA
    Mol Pharmacol 77:1025-36. 2010
    ..Our findings provide a potential mechanism by which increased PGE(2) biosynthesis could up-regulate the expression of HIF-1 alpha and promote tumorigenesis...
  100. pmc E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection
    David M Aronoff
    Divisions of Infectious Diseases, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Immunol 183:2642-9. 2009
    ..Pharmacological targeting of the PGE(2)-EP3 axis represents a novel area warranting greater investigative interest in the prevention and/or treatment of infectious diseases...
  101. ncbi Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor
    Kiyoshi Takayama
    Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:44147-54. 2002
    ..Thus, endogenous PGE(2) may modulate inflammation during atherogenesis and other inflammatory diseases by suppressing macrophage-derived chemokine production via the EP4 receptor...

Research Grants78

  1. Novel Approaches to the Assessment of Oral Mucosal Immu*
    Theresa Whiteside; Fiscal Year: 2003
    ..A better understanding of oral immunity in normal and HIV-infected mucosa is important for the development of new antiviral therapies, including oral antiviral vaccines. ..
  2. DNA-Based Vaccines for Oral Carcnoma
    Theresa Whiteside; Fiscal Year: 2005
    ....
  3. COX-2 Inhibitors, APC and Colon Cancer Prevention
    Kotha Subbaramaiah; Fiscal Year: 2009
    ..These studies will enhance our understanding of the mechanistic link between COX-2 and colorectal cancer and potentially assist us in optimizing the use of selective COX-2 inhibitors as therapy. ..
  4. SEX STEROID REGULATION OF IGF-I EXPRESSION IN BONE
    Thomas McCarthy; Fiscal Year: 2003
    ..Bone mass studies will be conducted using peripheral quantitative computer tomography, and will be correlated with basal and activated skeletal IGF-I expression. ..
  5. Anticholinesterase Neurotoxicity is Mediated by Oxidative Injury
    Dejan Milatovic; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEM
    ROBERT DE LISLE; Fiscal Year: 2003
    ..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..
  7. TRANSGENIC MOUSE MODELS OF PANCREATIC EXOCRINE FUNCTION
    ROBERT DE LISLE; Fiscal Year: 2003
    ..That over expresses Muclin in the pancreatic acinar cell using the rat elastase promoter to direct cell specific expression. ..
  8. Role of Survivin in Blood Stem Cell Cycle and Apoptosis
    LOUIS PELUS; Fiscal Year: 2007
    ....
  9. Aging Vitamin E, and Immune Function in Aged
    Simin Meydani; Fiscal Year: 2007
    ..This, in turn, will help in designing practical nutritional interventions to reverse and/or delay the age-associated dysregulation of immune and inflammatory responses as well as diseases associated with it. ..
  10. Aging: Mechanism & Prevention: 35th Annual Meeting of AGE
    Simin Meydani; Fiscal Year: 2006
    ..Special efforts will be devoted to encourage participation of underrepresented minorities. The meeting will be preceded by a Pre-conference on Calorie restriction. [unreadable] [unreadable] [unreadable] [unreadable]..
  11. GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITE
    Fredika Robertson; Fiscal Year: 2001
    ..The hypothesis driving this research is that NO and peroxynitrite are mutagenic, and could be important contributors to oxidative DNA damage and mutation in human epidermal keratinocytes at sites of inflammation. ..
  12. Chemokine induced hematopoietic stem cell mobilization
    LOUIS PELUS; Fiscal Year: 2009
    ....
  13. PHOSPHOLIPIDS AND ULCER PROTECTION
    Lenard Lichtenberger; Fiscal Year: 2002
    ....
  14. Altered Breast Methylation after Low/Hi Dose Isoflavones
    Edward Sauter; Fiscal Year: 2005
    ..abstract_text> ..
  15. Age-related changes in the proteome and lipidome of the immunological synapse
    Simin Meydani; Fiscal Year: 2008
    ..This map will enhance our understanding of the molecular bases of immune senescence, and will promote the development of strategies to reverse the detrimental changes associated with aging. [unreadable] [unreadable] [unreadable]..
  16. ESTROGEN BIOTRANSFORMATIONS AND BREAST CANCER ETIOLOGY
    ROBERT BRUEGGEMEIER; Fiscal Year: 2006
    ..3) To measure cellular levels of aromatase expression and cyclooxygenases expression in human breast cancer specimens. ..
  17. VITAMIN E AND INFECTION IN THE ELDERLY
    Simin Meydani; Fiscal Year: 2001
    ..The results are intended to provide basic and applied insight into the mechanisms involved, the goals to be realized, and ways to sharpen the intervention and enhance its impact. ..
  18. Amelioration of Uveitis by Aldose reductase Inhibition
    KOTA VENKATA RAMANA; Fiscal Year: 2010
    ..abstract_text> ..
  19. Clinical Studies with Phospholipid-Associated NSAIDs
    Lenard Lichtenberger; Fiscal Year: 2004
    ..i.d.) with diclofenac-PC, except in this case we will add a third arm of the study in which the subjects are administered the COX- inhibitor, Celecoxib, at a dose (200 mg b.i.d.) having equivalent therapeutic efficacy to diclofenac. ..
  20. CXC CHEMOKINE REGULATION OF PROSTATE CANCER ANGIOGENESIS
    Bethany Moore; Fiscal Year: 2002
    ..These studies should lead to new insights into the biology of prostate cancer growth and metastasis, and pave the way to adapt adjuvant therapies for the treatment of this widespread disease. ..
  21. The Effect of Black Cohosh Extract on the Human Breast
    Edward Sauter; Fiscal Year: 2004
    ..The findings should allow us to design a high quality R01 submission involving a larger, randomized study of longer duration which should provide some answers on the potential role of BCE in breast cancer. ..
  22. AN ENDOCANNABINOID MECHANISM FOR STRESS-INDUCED ANALGESIA
    ANDREA GRACE HOHMANN; Fiscal Year: 2010
    ..Furthermore, the results will provide essential information on the mechanisms responsible for endocannabinoid deactivation in the brain, which may facilitate the development of novel analgesic and anti- stress medicines. ..
  23. Regulation of Transepithelial Transport in PKD
    Rajeev Rohatgi; Fiscal Year: 2008
    ..SA II: To identify those factors that regulate the avid Na absorption seen in ARPKD cyst lining epithelial cells. ..
  24. Role of NF-kappaB phosphorylation in inflammatory signaling
    Josef Anrather; Fiscal Year: 2008
    ..In summary, these studies will establish the role of p65 phosphorylation in achieving signal specificity and provide new insights into the mechanism of NF-KappaB dependent pro-inflammatory gene regulation. ..
  25. Recombinant FIV vectors for the delivery of siRNA therapy to joints
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  26. ENDOCANNABINOID ANALGESIA: AN IN VIVO GENE TRANSFER - LIPIDOMICS APPROACH
    Andrea Hohmann; Fiscal Year: 2007
    ..Successful validation of our technological approach and hypotheses may facilitate development of endocannabinoid-based pharmacological and gene therapies for pain. [unreadable] [unreadable] [unreadable]..
  27. Biomarkers of COX-2 inhibitors in intraductal papillary mucinous neoplasm (IPMN)
    Christian Schmidt; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  28. Breast Cancer Prediction Using Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  29. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2009
    ..abstract_text> ..
  30. Chemosensitivity of Tachykinin-containing Lung Afferents
    Lu Yuan Lee; Fiscal Year: 2008
    ..The results obtained from this study should provide critical information for gaining new insights into the mechanisms underlying the airway hyperresponsiveness induced by cationic proteins. [unreadable] [unreadable]..
  31. Regulation of Embryonic Erythropoiesis by BMP Signaling
    Todd Evans; Fiscal Year: 2008
    ..Our experiments should help to define the specificity of an important stem and progenitor cell regulatory pathway that is controlled in blood cells by BMPs. ..
  32. Uptake of apoptotic cells
    Peter Henson; Fiscal Year: 2009
    ..Approaches includeuse of knockout cells and animals, molecular modification, biochemistry and cell biology and an extensive collaborative network. ..
  33. MOLECULAR DISSECTION OF E. HISTOLYTICA PATHOGENESIS
    William F Stenson; Fiscal Year: 2010
    ..Jr. The name of the principal investigator/programdirector must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OFCONTENTS Page Numbers Face Page 1 Description, ..
  34. Ang II and Norepinephrine in Cardiac Sympathetic Nerves
    Roberto Levi; Fiscal Year: 2009
    ..abstract_text> ..
  35. Opioid and Breast Cancer Growth and Metastasis
    Kalpna Gupta; Fiscal Year: 2009
    ..If our hypothesis are true, this Proposal may lead to the development of novel therapeutics for breast cancer treatment and to altered clinical decision making in treating pain in cancer patients. ..
  36. Genetics of Angiotensinogen-Mediated Hypertension: Stage, Background & Gender
    Donald E Kohan; Fiscal Year: 2010
    ..Our goal is to advance the specificity of clinical management and treatment of EH. ..
  37. Role of TRPV1 in Airway Hypersensitivity Induced by Inflammation
    Lu Yuan Lee; Fiscal Year: 2010
    ..The results obtained from these studies should bring a new insight into the pathogenesis and therapeutic strategy for alleviating the airway hypersensitivity. ..
  38. Collecting duct endothelin-1 and hypertension
    Donald Kohan; Fiscal Year: 2009
    ..Such information is important in understanding intrarenal mechanisms responsible for hypertension and salt and water retention. ..
  39. Development of an electrical diagnostic for melanoma
    Richard Nuccitelli; Fiscal Year: 2008
    ..If the handheld BFI is able to reliably detect malignant skin lesions, it will improve the quality of life for tens of thousands of dermatology patients in the United States alone. [unreadable] [unreadable] [unreadable]..
  40. Breast Cancer-Proximal Stroma Interaction & Aromatase
    Serdar E Bulun; Fiscal Year: 2010
    ..noncarrier controls. Proposed studies may lead to new pilot trials of treatment and prevention using p38/JNK inhibitors in BRCA1 mutation carriers. ..
  41. Botannical Extract Library Screeninig with Human ADAS Cells
    Jeffrey Gimble; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  42. Role of ghrelin in intestinal inflammation
    Dezheng Zhao; Fiscal Year: 2008
    ....
  43. PULMONARY C-NEURON HYPERSENSITIVITY:CELLULAR MECHANISMS
    Lu Yuan Lee; Fiscal Year: 2005
    ..This information may, therefore, help to develop new therapeutic strategies for alleviating the symptoms of bronchial hyperreactivity associated with airway mucosal inflammation. ..
  44. AIDS Diarrhea and Antiretroviral Drug Absorption
    Daniel Fitzgerald; Fiscal Year: 2006
    ..abstract_text> ..
  45. LIPID PEROXIDATION AND APOE IN ALZHEIMERS DISEASE
    Thomas Montine; Fiscal Year: 2003
    ..This new information will aid in laying the foundation for designing rational therapeutic approaches to ameliorate brain oxidative damage in Alzheimer's disease. ..
  46. Molecul Biology of Intestinal Lipid Transport/Metabolism
    NICHOLAS DAVIDSON; Fiscal Year: 2003
    ..abstract_text> ..
  47. Lipid Oxidation Products in Alzheimer's Disease
    Thomas Montine; Fiscal Year: 2007
    ..abstract_text> ..
  48. Th1-to Th2 shift of HSP65 responses and atherogenesis
    Yoshimi Shibata; Fiscal Year: 2005
    ..Finally, we will determine if transfusion of fit-1 +marrow cells from HK-BCG treated WT donors will restore the Thl-to-Th2 shifts in 89Sr-treated WT recipients. ..
  49. NEURONAL FUNCTION IN CRANIOFACIAL DEVELOPMENT
    Stephanos Kyrkanides; Fiscal Year: 2004
    ..abstract_text> ..
  50. Collectin-induced phagocytosis of apoptotic cells
    Peter Henson; Fiscal Year: 2004
    ..Finally, the role of collectins and calreticulin in removal of apoptotic cells and cell debris will be examined in the inflamed peritoneum and lung using inhibitors and knockout mice. ..
  51. Airway Inflammation: Bacterial Epithelial Interactions
    BRYAN HURLEY; Fiscal Year: 2004
    ..Results obtained from the following proposal may shed light on diseases involving bacterial mediated lung inflammation such as cystic fibrosis and should also provide new strategies directed towards treating lung disease. ..
  52. PROSTAGLANDINS IN PRIMATE OVULATORY FOLLICLES
    DIANE DUFFY; Fiscal Year: 2003
    ..This may provide insight into the mechanisms leading to infertility (e.g., leuteinized unruptured follice syndrome) and support the developoment of PG synthesis inhibitors of PG synthesis inhibitors for use as contraceptives. ..
  53. PHOSPHOINOSITIDE HYDROLYSIS AND BETA CELL SECRETION
    Walter Zawalich; Fiscal Year: 2006
    ..These aims will be accomplished by using sound principles of experimentation and employing isolated islets that retain their in vivo sensitivity to glucose. ..
  54. Phase ii intraperitoneal rhIL 12
    Ralph Freedman; Fiscal Year: 2002
    ..4) Determine whether expression of proangiogenic factors VEGF, FGF2 and IL-8 are decreased following IF rhIL- 12. ..
  55. Joint degeneration: Somatic mosaic analysis in a transgenic mouse
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  56. Molecular Targeting of 15-Lipoxygenase-1 in Colon Cancer
    Imad Shureiqi; Fiscal Year: 2007
    ..the feasibility of tumor selective targeting of 15-LOX-1 to inhibit tumorigenesis will pave the way for future preclinical and clinical development of therapeutic strategies based on molecularly targeting 15-LOX-1 ..
  57. CELLULAR AND MOLECULAR TARGETING OF TMJ DESTRUCTION
    DAVID TIPTON; Fiscal Year: 2002
    ..It is hoped that completion of these three aims will provide a detailed knowledge of the biological basis of TMJ destruction via synovial fibroblasts and MMP pathway. ..
  58. Development of a nanosecond pulsed electric field system to treat skin cancer
    Richard Nuccitelli; Fiscal Year: 2008
    ..It offers a scar-free alternative to surgery that could improve the quality of life for tens of thousands of dermatology patients. [unreadable] [unreadable] [unreadable]..
  59. PERIPHERAL CANNABINOID MODULATION OF PAIN TRANSMISSION
    Andrea Hohmann; Fiscal Year: 2005
    ..abstract_text> ..
  60. MEDIATORS OF INFLAMMATION IN INFLAMMATORY BOWEL DISEASE
    WILLIAM STENSON; Fiscal Year: 2006
    ..Manipulation of the epithelial response to radiation could lead to agents that protect normal epithelial cells during radiation therapy. ..
  61. Polarized DC as Melanoma Vaccine: Phase 1 Evaluation
    Pawel Kalinski; Fiscal Year: 2006
    ....
  62. CELIAC DISEASE IN OSTEOPOROSIS
    WILLIAM STENSON; Fiscal Year: 2004
    ..At the end of the year of therapy, bone mass indices will be repeated and the response to the therapy of the two groups will be compared. ..
  63. NITRIC OXIDE INHIBITOR AND LEISHMANIA PATHOGENESIS
    MARION CHAN; Fiscal Year: 2004
    ..Presently, only limited studies addressing this area have been performed. Our proposal fills this gap of knowledge. ..
  64. The effects of strain on vocal fold fibroblasts
    Ryan Branski; Fiscal Year: 2004
    ..Furthermore, it seeks to provide in vitro data in conjunction with the Sponsor's current NIH ROI. ..
  65. Constitutive NFKB and Carcinogenesis in Barrett's Esophagus
    Navtej Buttar; Fiscal Year: 2007
    ..Moreover, the information obtained from this study may help us understand the mechanisms involved in chronic injury-related cancers elsewhere in the body. [unreadable] [unreadable] [unreadable]..
  66. LIVER/LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 2003
    ....
  67. Combinational Chemoprevention of Esophageal Adenocarcin*
    Navtej Buttar; Fiscal Year: 2005
    ..abstract_text> ..
  68. Counterblance in Inflammation
    MARION CHAN; Fiscal Year: 2005
    ..If feedback mechanisms become a new focus then a groundbreaking paradigm shift would have been made for the development of treatment for arthritis and other inflammation-induced tissue damages. ..
  69. Physiologic role of collecting duct ciiliary proteins
    Donald Kohan; Fiscal Year: 2007
    ..Most importantly, this work may shed light on novel mechanisms involved in control of blood pressure and development of hypertension. [unreadable] [unreadable] [unreadable]..
  70. Prostaglandin I synthase, Thromboxane A synthase & Prostaglandin E synthase
    Ke He Ruan; Fiscal Year: 2009
    ....
  71. Duke-UNC-Stanford AMDC Unit
    Thomas Coffman; Fiscal Year: 2005
    ..We plan to share these technologies fully with other investigators to help accomplish the overall goals of the Mouse Models of Diabetic Complications Consortium. ..
  72. STRUCTURE & FUNCTION RELATIONSHIP: PROSTANOID RECEPTORS
    Ke He Ruan; Fiscal Year: 2008
    ..Determine the solution conformation of segments comprising the intracellular domains. ..
  73. Ninth International Conference on Endothelin (ET-9)
    Donald Kohan; Fiscal Year: 2005
    ..abstract_text> ..
  74. SHIGA LIKE TOXIN AND RENAL CELL DYSFUNCTION
    Donald Kohan; Fiscal Year: 2001
    ..These studies provide essential information on how and why HGEN are damaged in HUS. ..
  75. P2U(P2Y2)-PURINOCEPTOR AND WATER TRANSPORT IN RAT KIDNEY
    BELLAMKONDA KISHORE; Fiscal Year: 2004
    ..Successful completion of these studies will lead to significant insights into the AVP-independent mechanisms of regulation of collecting duct water permeability. ..
  76. Cell Signaling in the Kidney
    VICTOR SCHUSTER; Fiscal Year: 2007
    ....
  77. EFFECT OF SHIGATOXIN-1 ON BRAIN ENDOTHELIAL CELLS
    Donald Kohan; Fiscal Year: 2004
    ....