Genomes and Genes
Summary: The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
Publications310 found, 100 shown here
- Regulation of immune responses by prostaglandin E2Pawel Kalinski
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Immunol 188:21-8. 2012..Targeting the production, degradation, and responsiveness to PGE(2) provides tools to modulate the patterns of immunity in a wide range of diseases, from autoimmunity to cancer...
- The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironmentAlexander Greenhough
Department of Cellular and Molecular Medicine, Cancer Research UK Colorectal Tumour Biology Group, University of Bristol, University Walk, Clifton, Bristol, UK
Carcinogenesis 30:377-86. 2009....
- Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cellsPratima Sinha
Department of Biological Sciences, University of Maryland Baltimore County, University of Maryland, Baltimore, Maryland 21250, USA
Cancer Res 67:4507-13. 2007....
- Prostaglandin E receptorsYukihiko Sugimoto
Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
J Biol Chem 282:11613-7. 2007..Here we review recent advances in PGE receptor research...
- Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasisTrista E North
Stem Cell Program and Division of Hematology Oncology, Children s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 447:1007-11. 2007..The conserved role for PGE2 in the regulation of vertebrate HSC homeostasis indicates that modulation of the prostaglandin pathway may facilitate expansion of HSC number for therapeutic purposes...
- Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regenerationWolfram Goessling
Harvard Stem Cell Institute, Cambridge, MA 02138, USA
Cell 136:1136-47. 2009..Our work provides in vivo evidence that Wnt activation in stem cells requires PGE2, and suggests the PGE2/Wnt interaction is a master regulator of vertebrate regeneration and recovery...
- Prostaglandins as modulators of immunitySarah G Harris
Dept of Microbiology and the James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
Trends Immunol 23:144-50. 2002..Understanding the diverse activities of these prostaglandins is crucial for the development of new therapies aimed at immune modulation...
- PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environmentNatasa Obermajer
Department of Surgery, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Cancer Res 71:7463-70. 2011..Together, our findings elucidate a central role for PGE(2) in MDSC accumulation triggered by the CXCL12-CXCR4 pathway, providing a powerful rationale to target PGE(2) signaling in ovarian cancer therapy...
- Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansionChengcan Yao
Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
Nat Med 15:633-40. 2009..Thus, PGE2-EP4 signaling promotes immune inflammation through TH1 differentiation and TH17 expansion, and EP4 antagonism may be therapeutically useful for various immune diseases...
- Lipid mediator class switching during acute inflammation: signals in resolutionB D Levy
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Nat Immunol 2:612-9. 2001....
- Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E₂ and prostaglandin E₂ receptorsTripti Singh
Department of Dermatology, University of Alabama at Birmingham, 35294, USA
Carcinogenesis 32:86-92. 2011..Together, these results indicate for the first time that berberine inhibits melanoma cell migration, an essential step in invasion and metastasis, by inhibition of COX-2, PGE₂ and PGE₂ receptors...
- Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signalingKatia Boniface
Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
J Exp Med 206:535-48. 2009..These findings, together with the altered IL-12/IL-23 balance induced by PGE2 in dendritic cells, further highlight the crucial role of the inflammatory microenvironment in Th17 cell development and regulation...
- Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regenerationFang Li
Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA
Sci Signal 3:ra13. 2010..We propose to call the pathway by which executioner caspases in apoptotic cells promote wound healing and tissue regeneration in multicellular organisms the "phoenix rising" pathway...
- Prostaglandins and cancerD Wang
The Vanderbilt Ingram Cancer Center, Room 698, Preston Research Building, 2300 Pierce Ave, Nashville, Tennessee 37232 6838, USA
Gut 55:115-22. 2006..Recent efforts to identify the molecular mechanisms by which PGE(2) promotes tumour growth and metastasis may provide opportunities for the development of safer strategies for cancer prevention and treatment...
- Prostaglandin E(2) (PGE (2)) suppresses natural killer cell function primarily through the PGE(2) receptor EP4Dawn Holt
Department of Pathology, School of Medicine, University of Maryland, Baltimore, USA
Cancer Immunol Immunother 60:1577-86. 2011....
- The role of COX-2 in intestinal inflammation and colorectal cancerD Wang
Department of Cancer Biology and GI Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
Oncogene 29:781-8. 2010....
- Prostaglandin E2 and the pathogenesis of pulmonary fibrosisPaul D Bozyk
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Am J Respir Cell Mol Biol 45:445-52. 2011..This review highlights these recent advances and offers new insights into the potential ways that PGE(2) and its downstream signals can be regulated for therapeutic benefit in a disease that has no validated treatment options...
- Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitisYoshiyasu Esaki
Departments of Pharmacology and Anesthesiology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
Proc Natl Acad Sci U S A 107:12233-8. 2010....
- Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2O Morteau
Department of Medicine, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Clin Invest 105:469-78. 2000....
- Prostaglandin E2 promotes degranulation-independent release of MCP-1 from mast cellsTakayuki Nakayama
Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
J Leukoc Biol 79:95-104. 2006..These observations identify PGE2-induced MCP-1 release from MCs as a pathway underlying inflammation-associated angiogenesis and extend current understanding of the activities of PGE2...
- Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cellsNatasa Obermajer
Department of Surgery, University of Pittsburgh, Hillman Cancer Center, UPCI Research Pavilion, 5117 Center Ave, Pittsburgh, PA 15213 1863, USA
Blood 118:5498-505. 2011..The central role of COX2-PGE(2) feedback in the induction and persistence of MDSCs highlights the potential for its manipulation to enhance or suppress immune responses in cancer, autoimmunity, or transplantation...
- Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancerSherven Sharma
Department of Medicine, Lung Cancer Research Program, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1960, USA
Cancer Res 65:5211-20. 2005..Transfer of Treg cells or administration of PGE2 to mice receiving COX-2 inhibitors reversed these effects. We conclude that inhibition of COX-2/PGE2 suppresses Treg cell activity and enhances antitumor responses...
- Membrane prostaglandin E synthase-1: a novel therapeutic targetBengt Samuelsson
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden
Pharmacol Rev 59:207-24. 2007..These findings indicate that mPGES-1 is a potential target for the development of therapeutic agents for treatment of several diseases...
- Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretionDilprit Bagga
Division of Hematology Oncology, Department of Obstetrics and Gynecology, University of California, Los Angeles, CA 90095 1679, USA
Proc Natl Acad Sci U S A 100:1751-6. 2003..Taken together, our data suggest that successful replacement of omega-6 PUFA with omega-3 PUFA in cell membranes can result in a decreased cellular response to mitogenic and inflammatory stimuli...
- Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesisHoward F Tiano
Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Cancer Res 62:3395-401. 2002..Thus, both COX-1 and COX-2 have roles in keratinocyte differentiation, and we propose that the absence of either isoform causes premature terminal differentiation of initiated keratinocytes and reduced tumor formation...
- PGE2 inhibits natural killer and gamma delta T cell cytotoxicity triggered by NKR and TCR through a cAMP-mediated PKA type I-dependent signalingLudovic Martinet
INSERM, U 563, Centre de Physiopathologie de Toulouse Purpan, Toulouse F 31300, France
Biochem Pharmacol 80:838-45. 2010..In the discussion, we focused on how these data should impact particular approaches in the treatment of cancer...
- Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansionCarlo Chizzolini
Division of Immunology and Allergy, Department of Internal Medicine, University Hospital and School of Medicine, Geneva, Switzerland
Blood 112:3696-703. 2008....
- Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4Gabriel L Galea
School of Veterinary Sciences, University of Bristol, Bristol, United Kingdom
FEBS Lett 585:2450-4. 2011..These findings indicate early divergence in the signaling pathways stimulated by strain and establish PGE2/EP4 as the pathway used by strain to regulate Sost expression...
- Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cellsFelicita Baratelli
Lung Cancer Research Program of the Jonsson Comprehensive Cancer Center and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 175:1483-90. 2005..Finally, PGE2 up-regulated FOXP3 at both mRNA and protein levels and enhanced FOXP3 promoter activity. This is the first report indicating that PGE2 can modulate FOXP3 expression and T reg function in human lymphocytes...
- Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinomaAugusto C Ochoa
Stanley S Scott Cancer Center and Department of Pediatrics, Louisiana State University Health Sciences Center, 533 Bolivar Street, New Orleans, LA 70112, USA
Clin Cancer Res 13:721s-726s. 2007..Preliminary data suggest that prostaglandin E(2) produced by the tumor induces arginase I expression in MDSC. Therefore, blocking MDSC activity may enhance the therapeutic efficacy of immunotherapy in RCC...
- Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivityT A Samad
Department of Anatomy, University College London, London WC1E 6BT, UK
Nature 410:471-5. 2001..Thus, preventing central prostanoid production by inhibiting the interleukin-1beta-mediated induction of Cox-2 in neurons or by inhibiting central Cox-2 activity reduces centrally generated inflammatory pain hypersensitivity...
- Prostaglandin E2 synthesis and secretion: the role of PGE2 synthasesJean Y Park
The Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Clin Immunol 119:229-40. 2006..In this review, we summarize the synthesis and secretion of PGE2. In particular, we focus on the three isoforms of the terminal PGES, and discuss the potential of targeting PGES as a more precise strategy for inhibiting PGE2 production...
- Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivoKathleen M Leahy
Pharmacia, Mail Zone AA4C, 700 Chesterfield Parkway, Chesterfield, Missouri 63017, USA
Cancer Res 62:625-31. 2002..2-3.0-fold) in response to celecoxib. Thus, the antitumor activity of celecoxib may be attributable, at least in part, to a direct effect on host stromal elements, such as the angiogenic vasculature...
- Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancerMariam Dohadwala
Lung Cancer Research Program of the University of California at Los Angeles Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
Cancer Res 66:5338-45. 2006..Thus, blocking PGE(2) production or activity may contribute to both prevention and treatment of NSCLC...
- Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouseS G Morham
Department of Pathology, University of North Carolina at Chapel Hill 27599 7525, USA
Cell 83:473-82. 1995..Mice lacking COX-2 have normal inflammatory responses to treatments with tetradecanoyl phorbol acetate or with arachidonic acid. However, they develop severe nephropathy and are susceptible to peritonitis...
- Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestineMasayuki Fukata
Inflammatory Bowel Disease Center, Division of Gastroenterology, New York, New York, USA
Gastroenterology 131:862-77. 2006..We wished to test the hypothesis that cyclooxygenase 2 (Cox-2)-derived prostaglandin E2 (PGE2) is important in TLR4-related mucosal repair...
- Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signalingAlexandra I Medeiros
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
J Exp Med 206:61-8. 2009..They also identify an opportunity to reduce the incidence and severity of pneumonia in the setting of lung injury by pharmacologically targeting synthesis of PGE(2) or ligation of EP2...
- Prostaglandin E2, an immunoactivatorDaiji Sakata
Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
J Pharmacol Sci 112:1-5. 2010..In this perspective, we review these findings and discuss the prospect of EP4 antagonists as immunomodulatory drugs...
- The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gutKenji Kabashima
Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
J Clin Invest 109:883-93. 2002..We conclude that EP4 maintains intestinal homeostasis by keeping mucosal integrity and downregulating immune response...
- Identification and characterization of a novel type of membrane-associated prostaglandin E synthaseNaomi Tanikawa
Special Division for Human Life Technology, Cell Dynamics Research Group, National Institute of AIST, Midorigaoka, Ikeda, Osaka 563 8577, Japan
Biochem Biophys Res Commun 291:884-9. 2002....
- Prostaglandin E2 promotes lung cancer cell migration via EP4-betaArrestin1-c-Src signalsomeJae Il Kim
Department of Pathology, Medical College of Georgia, Augusta, Georgia, USA
Mol Cancer Res 8:569-77. 2010..Selective targeting of EP4 with a ligand antagonist may provide an efficient approach to better manage patients with advanced lung cancer...
- Lipopolysaccharide induces macrophage migration via prostaglandin D(2) and prostaglandin E(2)Tsuyoshi Tajima
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
J Pharmacol Exp Ther 326:493-501. 2008....
- Production of PGE(2) increases in tendons subjected to repetitive mechanical loading and induces differentiation of tendon stem cells into non-tenocytesJianying Zhang
MechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Orthop Res 28:198-203. 2010....
- Recruitment and activation of natural killer cells in vitro by a human dendritic cell vaccineKarin Gustafsson
Department of Neuroscience and Physiology, Goteborg University, Goteborg, Sweden
Cancer Res 68:5965-71. 2008....
- Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage deathMinjian Chen
Department of Medicine, Division of Rheumatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Exp Med 205:2791-801. 2008..These in vitro and in vivo data indicate that PGE(2) plays a critical role in inhibition of Mtb replication...
- Aberrant PGE₂ metabolism in bladder tumor microenvironment promotes immunosuppressive phenotype of tumor-infiltrating myeloid cellsEvgeniy Eruslanov
Department of Urology, University of Florida, College of Medicine, Gainesville, FL 32610, USA
Int Immunopharmacol 11:848-55. 2011....
- The cardinal role of the phospholipase A(2)/cyclooxygenase-2/prostaglandin E synthase/prostaglandin E(2) (PCPP) axis in inflammostasisA D Mancini
Department of Anatomy and Cell Biology, McGill University, 3640 University St, Montreal, QC H3A 2B2, Canada
Inflamm Res 60:1083-92. 2011....
- Tumor-secreted PGE2 inhibits CCL5 production in activated macrophages through cAMP/PKA signaling pathwayXuesong Qian
Division of Immunobiology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
J Biol Chem 286:2111-20. 2011....
- Prostaglandin E2 regulates renal cell carcinoma invasion through the EP4 receptor-Rap GTPase signal transduction pathwayJuanjuan Wu
Department of Pathology, Georgia Health Sciences University, Augusta, Georgia 30912, USA
J Biol Chem 286:33954-62. 2011..These results support the idea that targeted inhibition of EP4 signaling and restoration of Rap1GAP expression constitute a new strategy to control kidney cancer progression...
- Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min miceP C Chulada
Laboratory of Experimental Carcinogenesis and Mutagenesis, NIH, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Cancer Res 60:4705-8. 2000..The results indicate that COX-1, as well as COX-2, plays a key role in intestinal tumorigenesis and that COX-1 may also be a chemotherapeutic target for nonsteroidal anti-inflammatory drugs...
- Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesisT Tanioka
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
J Biol Chem 275:32775-82. 2000..Thus, functional coupling between COX-1 and cPGES/p23 may contribute to production of the PGE(2) that plays a role in maintenance of tissue homeostasis...
- Protective effects of DIDS against ethanol-induced gastric mucosal injury in ratsWei Zhao
Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Institutes of Medical Sciences, Department of Pathology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Acta Biochim Biophys Sin (Shanghai) 41:301-8. 2009..Our results suggested that DIDS is beneficial in rat model of gastric injury through mechanisms that involve inhibiting inflammatory cell infiltration and lipid peroxidation and up-regulating the COX-2/PGE2 pathway...
- Dietary grape seed proanthocyanidins inhibit 12-O-tetradecanoyl phorbol-13-acetate-caused skin tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated mouse skin, which is associated with the inhibition of inflammatory responsesSyed M Meeran
Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Carcinogenesis 30:520-8. 2009..Together, our results show that dietary GSPs inhibit chemical carcinogenesis in mouse skin and that the inhibition of skin tumorigenesis by GSPs is associated with the inhibition of inflammatory responses caused by tumor promoters...
- Dendritic cells issued in vitro from bone marrow produce PGE(2) that contributes to the immunomodulation induced by antigen-presenting cellsH Harizi
Laboratoire d'Immunologie, , Bordeaux, Cedex, 33076, France
Cell Immunol 209:19-28. 2001....
- The lung as a privileged site for the beneficial actions of PGE2Carlo Vancheri
Department of Internal and Specialistic Medicine, Section of Respiratory Diseases, University of Catania, Via Passo Gravina, 187, 95125, Catania, Italy
Trends Immunol 25:40-6. 2004....
- Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cellsKenji Kabashima
Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
Nat Med 9:744-9. 2003..PGE2-EP4 signaling thus facilitates initiation of skin immune responses by promoting the migration and maturation of Langerhans cells...
- Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgammaL Chastine Bell-Parikh
Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104 6084, USA
J Clin Invest 112:945-55. 2003..15d-PGJ2 is not the endogenous mediator of PPARgamma-dependent adipocyte activation and is unaltered in clinical settings in which PPARgamma activation has been implicated...
- The role of prostaglandin E2 in the immunopathogenesis of experimental pulmonary tuberculosisJavier Rangel Moreno
Experimental Pathology Section, Department of Pathology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Tlalpan, Mexico
Immunology 106:257-66. 2002....
- The role and regulation of COX-2 during viral infectionSarah A Steer
Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA
Viral Immunol 16:447-60. 2003....
- A critical role for prostaglandin E2 in podosome dissolution and induction of high-speed migration during dendritic cell maturationSuzanne F G van Helden
Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Immunol 177:1567-74. 2006..Together, these results show that maturation-induced podosome dissolution and loss of alpha(5)beta(1) integrin activity allow human DCs to undergo the transition from an adhesive to a highly migratory phenotype...
- Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMPDavid M Aronoff
Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0642, USA
J Immunol 173:559-65. 2004..Our data support a negative regulatory role for PGE(2) on the antimicrobial activity of AMs, which has important implications for future efforts to prevent and treat bacterial pneumonia...
- Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1Ryo Fukuda
McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
Cancer Res 63:2330-4. 2003..Thus, the activity of multiple signal transduction pathways is required for the HIF-1-mediated induction of VEGF expression in colon cancer cells exposed to PGE(2)...
- Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouseC Nataraj
Division of Nephrology, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC 27705, USA
J Clin Invest 108:1229-35. 2001....
- Human mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responsesChunli Feng
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Blood 107:3243-50. 2006..These functions explain the potency of PGE2 as a suppressor of early- and late-phase allergic responses...
- Prostaglandin E(2) induces fibroblast apoptosis by modulating multiple survival pathwaysSteven K Huang
Pulmonary and Critical Care Medicine, University of Michigan, 6301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, MI 48109 5642, USA
FASEB J 23:4317-26. 2009..They provide another dimension by which PGE(2) may inhibit, and perhaps even reverse, fibrogenesis in patients with interstitial lung disease...
- The induction of IL-10 by zymosan in dendritic cells depends on CREB activation by the coactivators CREB-binding protein and TORC2 and autocrine PGE2Yolanda Alvarez
Instituto de Biologia y Genetica Molecular, Consejo Superior de Investigaciones Cientificas, Valladolid, Spain
J Immunol 183:1471-9. 2009....
- Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axisMaria Domenica Castellone
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4340, USA
Science 310:1504-10. 2005..These findings may provide a molecular framework for the future evaluation of chemopreventive strategies for colorectal cancer...
- Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxiaAbderrahmane Kaidi
Cancer Research UK Colorectal Tumour Biology Research Group, Department of Cellular and Molecular Medicine, Faculty of Medical and Veterinary Science, Bristol University, Bristol BS8 1TD, United Kingdom
Cancer Res 66:6683-91. 2006..We propose that using modified COX-2-selective inhibitors, which are only activated under hypoxic conditions, could potentially be a novel more selective strategy for colorectal cancer prevention and treatment...
- Prostaglandin E₂-EP4 signaling suppresses adipocyte differentiation in mouse embryonic fibroblasts via an autocrine mechanismTomoaki Inazumi
Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
J Lipid Res 52:1500-8. 2011....
- Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chancesDaniel F Legler
Biotechnology Institute Thurgau BITg at the University of Konstanz, Unterseestrasse 47, Kreuzlingen, Switzerland
Int J Biochem Cell Biol 42:198-201. 2010..Therefore, pharmacological inhibition of COX enzymes and PGE(2) receptor antagonism is of great therapeutic interest...
- COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cellsMitsugu Fujita
Brain Tumor Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
Cancer Res 71:2664-74. 2011..Taken together, our findings show that the COX-2 pathway promotes gliomagenesis by directly supporting systemic development of MDSCs and their accumulation in the TME, where they limit CTL infiltration...
- Cyclooxygenase-2-issued prostaglandin e(2) enhances the production of endogenous IL-10, which down-regulates dendritic cell functionsHedi Harizi
Laboratoire d Immunologie, Unité Mixte de Recherche Centre National de la Recherche Scientifique, Universite Victor Segalen, Bordeaux 2, 33076 Bordeaux, France
J Immunol 168:2255-63. 2002..We conclude that COX-2-mediated PGE(2) up-regulates IL-10, which down-regulates IL-12 production and the APC function of BM-DC...
- Adenosine analogs and electromagnetic fields inhibit prostaglandin E2 release in bovine synovial fibroblastsM de Mattei
Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
Osteoarthritis Cartilage 17:252-62. 2009..To investigate the role of adenosine analogs and electromagnetic field (EMF) stimulation on prostaglandin E(2) (PGE(2)) release and cyclooxygenase-2 (COX-2) expression in bovine synovial fibroblasts (SFs)...
- IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cellsP Kalinski
Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
J Immunol 159:28-35. 1997..Since type 2 Th responses are protective in several Th1-related autoimmune disorders, PGE2-DC may be considered for use in immunotherapy...
- Prostaglandin E(2) couples through EP(4) prostanoid receptors to induce IL-8 production in human colonic epithelial cell linesI Dey
Departments of Microbiology and Infectious Diseases, Health Sciences Centre, University of Calgary, AB, Canada
Br J Pharmacol 156:475-85. 2009..The aim of this study was to identify the role of the EP(2) and EP(4) receptor subtype(s) on two human colonic epithelial cell lines (Caco-2 and T84), in regulating PGE(2)-induced IL-8 production...
- Effect of high and low sodium intake on urinary aquaporin-2 excretion in healthy humansCarolina Cannillo Graffe
Dept of Medical Research, Holstebro Hospital, Holstebro, Denmark
Am J Physiol Renal Physiol 302:F264-75. 2012..In conclusion, u-AQP2 was increased during HS intake, indicating that water transport via AQP2 was increased. The effect was mediated by an unknown AVP-independent mechanism...
- Prostaglandins in bone: bad cop, good cop?Katherine A Blackwell
New England Musculoskeletal Institute, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT, USA
Trends Endocrinol Metab 21:294-301. 2010..Further analysis of COX-2 and PG receptors and their downstream G-protein signaling in bone could provide important clues to the regulation of skeletal cell growth in both health and disease...
- Periodontal disease increases the risk of severe pre-eclampsia among pregnant womenVarol Canakci
Department of Periodontology, School of Dentistry, Ataturk University, Erzurum, Turkey
J Clin Periodontol 34:639-45. 2007....
- 3-(4-(tert-Octyl)phenoxy)propane-1,2-diol suppresses inflammatory responses via inhibition of multiple kinasesTao Yu
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea
Biochem Pharmacol 83:1540-51. 2012..Therefore, this compound has the potential to be served as a lead chemical for developing a promising anti-inflammatory drug candidate with multiple kinase targets...
- PGE2 promotes angiogenesis through EP4 and PKA Cγ pathwayYushan Zhang
Urology and Prostate Disease Center, University of Florida College of Medicine, Gainesville, USA
Blood 118:5355-64. 2011..These results support the existence of EP4-to-PKA angiogenic signal and provide rationale for use of selective EP4 signal inhibitors as a probable strategy to control pathologic angiogenesis...
- The prostaglandin E2 receptor EP4 is expressed by human platelets and potently inhibits platelet aggregation and thrombus formationSonia Philipose
Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, A 8010 Graz, Austria
Arterioscler Thromb Vasc Biol 30:2416-23. 2010..The platelet-stimulating effect of PGE(2) has been suggested to involve EP3 receptors. Here we analyzed the receptor usage relating to the inhibitory effect of PGE(2)...
- Prostaglandin E2 induces matrix metalloproteinase 9 expression in dendritic cells through two independent signaling pathways leading to activator protein 1 (AP-1) activationJui Hung Yen
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
J Biol Chem 286:38913-23. 2011..Our results describe a new molecular mechanism for the effect of PGE2 on MMP-9 production in DCs that could lead to future therapeutic approaches using ERK inhibitors to regulate DC migration...
- Elevated expression of prostaglandin receptor and increased release of prostaglandin E2 maintain the survival of CD45RO+ T cells in the inflamed human pleural spaceElisabetta Pace
Istituto di Biomedicina e Immunologia Molecolare, Unità di Immunopatologia e Farmacologia Clinica e Sperimentale dell Apparato respiratorio, Consiglio Nazionale delle Ricerche, Palermo, Italy
Immunology 121:427-36. 2007....
- Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastomaAgnes Rasmuson
Childhood Cancer Research Unit, Department of Women s and Children s Health, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 7:e29331. 2012....
- Prostaglandin E2 induces hypertrophic changes and suppresses alpha-skeletal actin gene expression in rat cardiomyocytesSatoru Miyatake
Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
J Cardiovasc Pharmacol 50:548-54. 2007..In conclusion, PGE2 induced hypertrophic changes in cardiomyocytes and attenuated alpha-skeletal actin gene expression in part via EP4...
- Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathwayHiroko Oshima
Division of Genetics, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
Gastroenterology 131:1086-95. 2006..To investigate the role of Wnt and PGE(2) in gastric cancer, we have generated transgenic mice that activate both pathways and examined their phenotypes...
- Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinasesJehoon Lee
Reproductive Endocrinology and Cell Signaling Laboratory, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, United States
Mol Cell Endocrinol 332:306-13. 2011..These novel findings provide an important molecular and cellular framework for further evaluation of selective inhibition of EP2 and EP4 as potential nonsteroidal therapy for endometriosis in childbearing-age women...
- Prostaglandin E2 induces vascular relaxation by E-prostanoid 4 receptor-mediated activation of endothelial nitric oxide synthaseAna Marija Hristovska
Department of Physiology and Pharmacology, University of Southern Denmark, Odense, Denmark
Hypertension 50:525-30. 2007....
- ESAT-6 induced COX-2 expression involves coordinated interplay between PI3K and MAPK signalingSenthil Kumar A
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India
Mol Immunol 49:655-63. 2012..These findings would serve as a paradigm to understand pathogenesis of mycobacterial infection and clearly pave a way towards development of novel therapeutics...
- Francisella tularensis-infected macrophages release prostaglandin E2 that blocks T cell proliferation and promotes a Th2-like responseMatthew D Woolard
Department of Microbiology and Immunology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
J Immunol 178:2065-74. 2007..From these data, we conclude that F. tularensis can alter host T cell responses by causing macrophages to produce PGE(2). This study defines a previously unknown mechanism used by F. tularensis to modulate adaptive immunity...
- PGE1 and PGE2 modify platelet function through different prostanoid receptorsDavid Iyu
Cardiovascular Medicine, University of Nottingham, Nottingham, UK
Prostaglandins Other Lipid Mediat 94:9-16. 2011..In both cases the overall effects on platelet function reflect the balance between promotory and inhibitory effects at receptors that have opposite effects on adenylate cyclase...
- β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cellsHelena J M Smartt
Cancer Research UK Colorectal Tumour Biology Research Group, School of Cellular and Molecular Medicine, University Walk, University of Bristol, Bristol, UK
Gut 61:1306-14. 2012..As Wnt/β-catenin signalling is also deregulated early in colorectal neoplasia, a study was undertaken to determine whether β-catenin represses 15-PGDH expression...
- Activation of E-prostanoid4 and E-prostanoid2 receptors inhibits TNF-alpha release from human alveolar macrophagesM J Ratcliffe
Dept of Molecular Biology, AstraZeneca Research and Development Charnwood, Bakewell Road, Loughborough, LE11 5RH, UK
Eur Respir J 29:986-94. 2007..These data indicate that both E-prostanoid(4) and E-prostanoid(2) selective agonists may have anti-inflammatory properties in lung diseases where macrophages play a role...
- A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantationLeah L N Hubbard
Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 184:6299-308. 2010..Therefore, strategies to limit IRAK-M elevation post-BMT may be efficacious in reducing patient susceptibility to infection...
- Nitric oxide synthase 1 and cyclooxygenase-2 enzymes are targets of muscarinic activation in normal and inflamed NIH3T3 cellsA J Español
Centro de Estudios Farmacológicos y Botánicos CEFYBO CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 piso 16, Buenos Aires, CP 1121, Argentina
Inflamm Res 59:227-38. 2010..In this work, we investigate the action of the muscarinic agonist carbachol (CARB) on the expression and function of nitric oxide synthase (NOS) and cyclooxygenase (COX) in fibroblasts under normal or inflammatory conditions...
- Interaction of eosinophils with endothelial cells is modulated by prostaglandin EP4 receptorsViktoria Konya
Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
Eur J Immunol 41:2379-89. 2011....
- Prostaglandin E2 plays a key role in the immunosuppressive properties of adipose and bone marrow tissue-derived mesenchymal stromal cellsRosa Yañez
Hematopoiesis and Gene Therapy Division, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas andCentro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain
Exp Cell Res 316:3109-23. 2010..In conclusion, we propose that PGE2 is a soluble factor mediating most of the immunosuppressive effects of Ad-MSCs and BM-MSCs over p-DCs maturation and activated T lymphocytes proliferation and cytokine secretion...
- Anti-inflammation therapy by activation of prostaglandin EP4 receptor in cardiovascular and other inflammatory diseasesEva H C Tang
Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong
J Cardiovasc Pharmacol 59:116-23. 2012..Overall, EP4 activation produces powerful anti-inflammatory responses in many experimental diseases, rendering EP4 agonists attractive agents to attenuate syndromes associated with inflammation...
- EP1 prostanoid receptor coupling to G i/o up-regulates the expression of hypoxia-inducible factor-1 alpha through activation of a phosphoinositide-3 kinase signaling pathwayRuyue Ji
Department of Pharmacology and Toxicology, College of Pharmacy The University of Arizona, 1703 E Mabel St, Tucson, AZ 85721 0207, USA
Mol Pharmacol 77:1025-36. 2010..Our findings provide a potential mechanism by which increased PGE(2) biosynthesis could up-regulate the expression of HIF-1 alpha and promote tumorigenesis...
- E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infectionDavid M Aronoff
Divisions of Infectious Diseases, University of Michigan Health System, Ann Arbor, MI 48109, USA
J Immunol 183:2642-9. 2009..Pharmacological targeting of the PGE(2)-EP3 axis represents a novel area warranting greater investigative interest in the prevention and/or treatment of infectious diseases...
- Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptorKiyoshi Takayama
Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 277:44147-54. 2002..Thus, endogenous PGE(2) may modulate inflammation during atherogenesis and other inflammatory diseases by suppressing macrophage-derived chemokine production via the EP4 receptor...
- Novel Approaches to the Assessment of Oral Mucosal Immu*Theresa Whiteside; Fiscal Year: 2003..A better understanding of oral immunity in normal and HIV-infected mucosa is important for the development of new antiviral therapies, including oral antiviral vaccines. ..
- DNA-Based Vaccines for Oral CarcnomaTheresa Whiteside; Fiscal Year: 2005....
- COX-2 Inhibitors, APC and Colon Cancer PreventionKotha Subbaramaiah; Fiscal Year: 2009..These studies will enhance our understanding of the mechanistic link between COX-2 and colorectal cancer and potentially assist us in optimizing the use of selective COX-2 inhibitors as therapy. ..
- SEX STEROID REGULATION OF IGF-I EXPRESSION IN BONEThomas McCarthy; Fiscal Year: 2003..Bone mass studies will be conducted using peripheral quantitative computer tomography, and will be correlated with basal and activated skeletal IGF-I expression. ..
- Anticholinesterase Neurotoxicity is Mediated by Oxidative InjuryDejan Milatovic; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEMROBERT DE LISLE; Fiscal Year: 2003..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..
- TRANSGENIC MOUSE MODELS OF PANCREATIC EXOCRINE FUNCTIONROBERT DE LISLE; Fiscal Year: 2003..That over expresses Muclin in the pancreatic acinar cell using the rat elastase promoter to direct cell specific expression. ..
- Role of Survivin in Blood Stem Cell Cycle and ApoptosisLOUIS PELUS; Fiscal Year: 2007....
- Aging Vitamin E, and Immune Function in AgedSimin Meydani; Fiscal Year: 2007..This, in turn, will help in designing practical nutritional interventions to reverse and/or delay the age-associated dysregulation of immune and inflammatory responses as well as diseases associated with it. ..
- Aging: Mechanism & Prevention: 35th Annual Meeting of AGESimin Meydani; Fiscal Year: 2006..Special efforts will be devoted to encourage participation of underrepresented minorities. The meeting will be preceded by a Pre-conference on Calorie restriction. [unreadable] [unreadable] [unreadable] [unreadable]..
- GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITEFredika Robertson; Fiscal Year: 2001..The hypothesis driving this research is that NO and peroxynitrite are mutagenic, and could be important contributors to oxidative DNA damage and mutation in human epidermal keratinocytes at sites of inflammation. ..
- Chemokine induced hematopoietic stem cell mobilizationLOUIS PELUS; Fiscal Year: 2009....
- PHOSPHOLIPIDS AND ULCER PROTECTIONLenard Lichtenberger; Fiscal Year: 2002....
- Altered Breast Methylation after Low/Hi Dose IsoflavonesEdward Sauter; Fiscal Year: 2005..abstract_text> ..
- Age-related changes in the proteome and lipidome of the immunological synapseSimin Meydani; Fiscal Year: 2008..This map will enhance our understanding of the molecular bases of immune senescence, and will promote the development of strategies to reverse the detrimental changes associated with aging. [unreadable] [unreadable] [unreadable]..
- ESTROGEN BIOTRANSFORMATIONS AND BREAST CANCER ETIOLOGYROBERT BRUEGGEMEIER; Fiscal Year: 2006..3) To measure cellular levels of aromatase expression and cyclooxygenases expression in human breast cancer specimens. ..
- VITAMIN E AND INFECTION IN THE ELDERLYSimin Meydani; Fiscal Year: 2001..The results are intended to provide basic and applied insight into the mechanisms involved, the goals to be realized, and ways to sharpen the intervention and enhance its impact. ..
- Amelioration of Uveitis by Aldose reductase InhibitionKOTA VENKATA RAMANA; Fiscal Year: 2010..abstract_text> ..
- Clinical Studies with Phospholipid-Associated NSAIDsLenard Lichtenberger; Fiscal Year: 2004..i.d.) with diclofenac-PC, except in this case we will add a third arm of the study in which the subjects are administered the COX- inhibitor, Celecoxib, at a dose (200 mg b.i.d.) having equivalent therapeutic efficacy to diclofenac. ..
- CXC CHEMOKINE REGULATION OF PROSTATE CANCER ANGIOGENESISBethany Moore; Fiscal Year: 2002..These studies should lead to new insights into the biology of prostate cancer growth and metastasis, and pave the way to adapt adjuvant therapies for the treatment of this widespread disease. ..
- The Effect of Black Cohosh Extract on the Human BreastEdward Sauter; Fiscal Year: 2004..The findings should allow us to design a high quality R01 submission involving a larger, randomized study of longer duration which should provide some answers on the potential role of BCE in breast cancer. ..
- AN ENDOCANNABINOID MECHANISM FOR STRESS-INDUCED ANALGESIAANDREA GRACE HOHMANN; Fiscal Year: 2010..Furthermore, the results will provide essential information on the mechanisms responsible for endocannabinoid deactivation in the brain, which may facilitate the development of novel analgesic and anti- stress medicines. ..
- Regulation of Transepithelial Transport in PKDRajeev Rohatgi; Fiscal Year: 2008..SA II: To identify those factors that regulate the avid Na absorption seen in ARPKD cyst lining epithelial cells. ..
- Role of NF-kappaB phosphorylation in inflammatory signalingJosef Anrather; Fiscal Year: 2008..In summary, these studies will establish the role of p65 phosphorylation in achieving signal specificity and provide new insights into the mechanism of NF-KappaB dependent pro-inflammatory gene regulation. ..
- Recombinant FIV vectors for the delivery of siRNA therapy to jointsStephanos Kyrkanides; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- ENDOCANNABINOID ANALGESIA: AN IN VIVO GENE TRANSFER - LIPIDOMICS APPROACHAndrea Hohmann; Fiscal Year: 2007..Successful validation of our technological approach and hypotheses may facilitate development of endocannabinoid-based pharmacological and gene therapies for pain. [unreadable] [unreadable] [unreadable]..
- Biomarkers of COX-2 inhibitors in intraductal papillary mucinous neoplasm (IPMN)Christian Schmidt; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Breast Cancer Prediction Using Nipple Aspirate FluidEdward Sauter; Fiscal Year: 2007..unreadable] [unreadable]..
- PHAGOCYTE RESOLVING METABOLISMCharles Serhan; Fiscal Year: 2009..abstract_text> ..
- Chemosensitivity of Tachykinin-containing Lung AfferentsLu Yuan Lee; Fiscal Year: 2008..The results obtained from this study should provide critical information for gaining new insights into the mechanisms underlying the airway hyperresponsiveness induced by cationic proteins. [unreadable] [unreadable]..
- Regulation of Embryonic Erythropoiesis by BMP SignalingTodd Evans; Fiscal Year: 2008..Our experiments should help to define the specificity of an important stem and progenitor cell regulatory pathway that is controlled in blood cells by BMPs. ..
- Uptake of apoptotic cellsPeter Henson; Fiscal Year: 2009..Approaches includeuse of knockout cells and animals, molecular modification, biochemistry and cell biology and an extensive collaborative network. ..
- MOLECULAR DISSECTION OF E. HISTOLYTICA PATHOGENESISWilliam F Stenson; Fiscal Year: 2010..Jr. The name of the principal investigator/programdirector must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OFCONTENTS Page Numbers Face Page 1 Description, ..
- Ang II and Norepinephrine in Cardiac Sympathetic NervesRoberto Levi; Fiscal Year: 2009..abstract_text> ..
- Opioid and Breast Cancer Growth and MetastasisKalpna Gupta; Fiscal Year: 2009..If our hypothesis are true, this Proposal may lead to the development of novel therapeutics for breast cancer treatment and to altered clinical decision making in treating pain in cancer patients. ..
- Genetics of Angiotensinogen-Mediated Hypertension: Stage, Background & GenderDonald E Kohan; Fiscal Year: 2010..Our goal is to advance the specificity of clinical management and treatment of EH. ..
- Role of TRPV1 in Airway Hypersensitivity Induced by InflammationLu Yuan Lee; Fiscal Year: 2010..The results obtained from these studies should bring a new insight into the pathogenesis and therapeutic strategy for alleviating the airway hypersensitivity. ..
- Collecting duct endothelin-1 and hypertensionDonald Kohan; Fiscal Year: 2009..Such information is important in understanding intrarenal mechanisms responsible for hypertension and salt and water retention. ..
- Development of an electrical diagnostic for melanomaRichard Nuccitelli; Fiscal Year: 2008..If the handheld BFI is able to reliably detect malignant skin lesions, it will improve the quality of life for tens of thousands of dermatology patients in the United States alone. [unreadable] [unreadable] [unreadable]..
- Breast Cancer-Proximal Stroma Interaction & AromataseSerdar E Bulun; Fiscal Year: 2010..noncarrier controls. Proposed studies may lead to new pilot trials of treatment and prevention using p38/JNK inhibitors in BRCA1 mutation carriers. ..
- Botannical Extract Library Screeninig with Human ADAS CellsJeffrey Gimble; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Role of ghrelin in intestinal inflammationDezheng Zhao; Fiscal Year: 2008....
- PULMONARY C-NEURON HYPERSENSITIVITY:CELLULAR MECHANISMSLu Yuan Lee; Fiscal Year: 2005..This information may, therefore, help to develop new therapeutic strategies for alleviating the symptoms of bronchial hyperreactivity associated with airway mucosal inflammation. ..
- AIDS Diarrhea and Antiretroviral Drug AbsorptionDaniel Fitzgerald; Fiscal Year: 2006..abstract_text> ..
- LIPID PEROXIDATION AND APOE IN ALZHEIMERS DISEASEThomas Montine; Fiscal Year: 2003..This new information will aid in laying the foundation for designing rational therapeutic approaches to ameliorate brain oxidative damage in Alzheimer's disease. ..
- Molecul Biology of Intestinal Lipid Transport/MetabolismNICHOLAS DAVIDSON; Fiscal Year: 2003..abstract_text> ..
- Lipid Oxidation Products in Alzheimer's DiseaseThomas Montine; Fiscal Year: 2007..abstract_text> ..
- Th1-to Th2 shift of HSP65 responses and atherogenesisYoshimi Shibata; Fiscal Year: 2005..Finally, we will determine if transfusion of fit-1 +marrow cells from HK-BCG treated WT donors will restore the Thl-to-Th2 shifts in 89Sr-treated WT recipients. ..
- NEURONAL FUNCTION IN CRANIOFACIAL DEVELOPMENTStephanos Kyrkanides; Fiscal Year: 2004..abstract_text> ..
- Collectin-induced phagocytosis of apoptotic cellsPeter Henson; Fiscal Year: 2004..Finally, the role of collectins and calreticulin in removal of apoptotic cells and cell debris will be examined in the inflamed peritoneum and lung using inhibitors and knockout mice. ..
- Airway Inflammation: Bacterial Epithelial InteractionsBRYAN HURLEY; Fiscal Year: 2004..Results obtained from the following proposal may shed light on diseases involving bacterial mediated lung inflammation such as cystic fibrosis and should also provide new strategies directed towards treating lung disease. ..
- PROSTAGLANDINS IN PRIMATE OVULATORY FOLLICLESDIANE DUFFY; Fiscal Year: 2003..This may provide insight into the mechanisms leading to infertility (e.g., leuteinized unruptured follice syndrome) and support the developoment of PG synthesis inhibitors of PG synthesis inhibitors for use as contraceptives. ..
- PHOSPHOINOSITIDE HYDROLYSIS AND BETA CELL SECRETIONWalter Zawalich; Fiscal Year: 2006..These aims will be accomplished by using sound principles of experimentation and employing isolated islets that retain their in vivo sensitivity to glucose. ..
- Phase ii intraperitoneal rhIL 12Ralph Freedman; Fiscal Year: 2002..4) Determine whether expression of proangiogenic factors VEGF, FGF2 and IL-8 are decreased following IF rhIL- 12. ..
- Joint degeneration: Somatic mosaic analysis in a transgenic mouseStephanos Kyrkanides; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Molecular Targeting of 15-Lipoxygenase-1 in Colon CancerImad Shureiqi; Fiscal Year: 2007..the feasibility of tumor selective targeting of 15-LOX-1 to inhibit tumorigenesis will pave the way for future preclinical and clinical development of therapeutic strategies based on molecularly targeting 15-LOX-1 ..
- CELLULAR AND MOLECULAR TARGETING OF TMJ DESTRUCTIONDAVID TIPTON; Fiscal Year: 2002..It is hoped that completion of these three aims will provide a detailed knowledge of the biological basis of TMJ destruction via synovial fibroblasts and MMP pathway. ..
- Development of a nanosecond pulsed electric field system to treat skin cancerRichard Nuccitelli; Fiscal Year: 2008..It offers a scar-free alternative to surgery that could improve the quality of life for tens of thousands of dermatology patients. [unreadable] [unreadable] [unreadable]..
- PERIPHERAL CANNABINOID MODULATION OF PAIN TRANSMISSIONAndrea Hohmann; Fiscal Year: 2005..abstract_text> ..
- MEDIATORS OF INFLAMMATION IN INFLAMMATORY BOWEL DISEASEWILLIAM STENSON; Fiscal Year: 2006..Manipulation of the epithelial response to radiation could lead to agents that protect normal epithelial cells during radiation therapy. ..
- Polarized DC as Melanoma Vaccine: Phase 1 EvaluationPawel Kalinski; Fiscal Year: 2006....
- CELIAC DISEASE IN OSTEOPOROSISWILLIAM STENSON; Fiscal Year: 2004..At the end of the year of therapy, bone mass indices will be repeated and the response to the therapy of the two groups will be compared. ..
- NITRIC OXIDE INHIBITOR AND LEISHMANIA PATHOGENESISMARION CHAN; Fiscal Year: 2004..Presently, only limited studies addressing this area have been performed. Our proposal fills this gap of knowledge. ..
- The effects of strain on vocal fold fibroblastsRyan Branski; Fiscal Year: 2004..Furthermore, it seeks to provide in vitro data in conjunction with the Sponsor's current NIH ROI. ..
- Constitutive NFKB and Carcinogenesis in Barrett's EsophagusNavtej Buttar; Fiscal Year: 2007..Moreover, the information obtained from this study may help us understand the mechanisms involved in chronic injury-related cancers elsewhere in the body. [unreadable] [unreadable] [unreadable]..
- LIVER/LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIAGeorge Matuschak; Fiscal Year: 2003....
- Combinational Chemoprevention of Esophageal Adenocarcin*Navtej Buttar; Fiscal Year: 2005..abstract_text> ..
- Counterblance in InflammationMARION CHAN; Fiscal Year: 2005..If feedback mechanisms become a new focus then a groundbreaking paradigm shift would have been made for the development of treatment for arthritis and other inflammation-induced tissue damages. ..
- Physiologic role of collecting duct ciiliary proteinsDonald Kohan; Fiscal Year: 2007..Most importantly, this work may shed light on novel mechanisms involved in control of blood pressure and development of hypertension. [unreadable] [unreadable] [unreadable]..
- Prostaglandin I synthase, Thromboxane A synthase & Prostaglandin E synthaseKe He Ruan; Fiscal Year: 2009....
- Duke-UNC-Stanford AMDC UnitThomas Coffman; Fiscal Year: 2005..We plan to share these technologies fully with other investigators to help accomplish the overall goals of the Mouse Models of Diabetic Complications Consortium. ..
- STRUCTURE & FUNCTION RELATIONSHIP: PROSTANOID RECEPTORSKe He Ruan; Fiscal Year: 2008..Determine the solution conformation of segments comprising the intracellular domains. ..
- Ninth International Conference on Endothelin (ET-9)Donald Kohan; Fiscal Year: 2005..abstract_text> ..
- SHIGA LIKE TOXIN AND RENAL CELL DYSFUNCTIONDonald Kohan; Fiscal Year: 2001..These studies provide essential information on how and why HGEN are damaged in HUS. ..
- P2U(P2Y2)-PURINOCEPTOR AND WATER TRANSPORT IN RAT KIDNEYBELLAMKONDA KISHORE; Fiscal Year: 2004..Successful completion of these studies will lead to significant insights into the AVP-independent mechanisms of regulation of collecting duct water permeability. ..
- Cell Signaling in the KidneyVICTOR SCHUSTER; Fiscal Year: 2007....
- EFFECT OF SHIGATOXIN-1 ON BRAIN ENDOTHELIAL CELLSDonald Kohan; Fiscal Year: 2004....